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Strontium
1/11/08
11:57 AM
Page 1
Science-Based
Nutrition™
Strontium
Bone Maker
Strontium Bone Maker
60 and 120 Veggie Caps
Ingredients per 2 capsules:
Strontium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .680 mg
(elemental from 2194mg strontium citrate)
Excipients: modified cellulose (vegetarian capsule), cellulose, magnesium stearate (vegetable
source).
Suggested Adult Use: Take two capsules daily.
Calcium intake must also be adequate.
Take your calcium supplement separate, i.e. not
with the Strontium Bone Maker and at least
2 to 3 hours apart or first thing in the morning
and take your calcium an hour later. Take with
or without food.
Note: Individuals with severe renal impairment
should check with a health practitioner before
using this product.
Suitable for vegetarians.
NOTE: In addition to taking sufficient calcium (not at the
same time as you take your Strontium Bone Maker), D3
should also be taken in adequate amounts.
Ingredients
Strontium is a naturally occurring mineral present in water
and food. Trace amounts of strontium are found in the
human skeleton. Strontium has an affinity for bone and is
taken up at the bone matrix crystal surface. The influence
of strontium on bone metabolism has been researched
since the 1950's.1 Studies show that strontium positively
affects bone metabolism to promote bone formation and
decrease bone resorption, leading to normalized bone
density. Strontium citrate is a naturally occurring compound supplying stable strontium that is safe and suitable
for consumption as a dietary supplement. (This form
strontium is entirely different from the radioactive
“strontium-90” formed by nuclear fission.)
The Role of Stable Strontium in Human Bone
Strontium is found naturally in the human skeleton. The
level of strontium in bone tissue is approximately 3.5% of
the calcium content of bone.2 Strontium taken orally
through the diet and from supplements is preferentially
incorporated into the teeth and bones. Research suggests
that the oral absorption of strontium is dependent on age
and decreases with increasing age. Scientists have suggested two methods of absorption of strontium from the
gastrointestinal tract: passive diffusion and carrier-mediated absorption. In adults, strontium is absorbed to a lesser
extent than calcium, possibly due to the larger molecular
size of strontium in comparison to the calcium molecule.
Both calcium and strontium compete with one another for
absorption in the intestines. High dietary intake of calcium
has been shown to reduce concurrent absorption of strontium. It has been proposed that when both elements are
present together, twice the amount of calcium is absorbed
from the intestines in comparison with strontium.3
Animal studies suggest that extremely high dietary intakes
of strontium, in the absence of adequate calcium intake,
can actually disturb bone mineralization. At such concentration levels strontium replaces calcium ions in bone. The
unbalanced incorporation of strontium into bone tissue in
the place of calcium may cause a disturbance of the bone
lattice, resulting in decreased bone mineral density.3 It is
precisely for this reason that calcium intake must be adequate when supplementing with strontium.
Further studies in animals reveal that strontium given as a
part of the normal diet (when calcium intake is adequate)
may have profound effects on bone formation and density.
Oral administration of strontium doses to rats was shown to
enhance the rate of bone formation and trabecular bone
density.3
Benefits
Helps Maintain Strong, Healthy Bones*
Mechanism of Action
Strontium is a bone-seeking mineral incorporated by ionic
substitution for calcium onto the crystal surface of bone.2
Researchers have looked at the therapeutic potential of
strontium based on in vitro, animal and human studies. After
assessing and analyzing the results of several investigations,
scientists theorize that strontium may benefit bone health
via a two-pronged effect. It appears that strontium interacts
with the cells responsible for the normal bone remodeling
process.The cells responsible for bone formation are known
as osteoblasts, and the cells responsible for bone breakdown, or resorption, are called the osteoclasts. Strontium
may stimulate the replication of pre-osteoblasts, leading to
an increased proliferation of osteoblasts (cells that build
bone). This causes an increased synthesis of bone matrix. In
terms of effects on osteoclasts (cells
responsible for bone
resorption), in vitro work
shows that strontium
directly inhibits their
activity and prevents bone breakdown.5,6
Animal
Studies
Animal
studies
have shown that
supplementation
with strontium is
extremely beneficial as a bone
building catalyst.
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Strontium Bone Maker
continued
In one such study, strontium administered at low doses has been shown
to increase the number of bone forming sites in thighbones of adult
rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.7 A second study in rats indicated that
strontium could reverse bone loss associated with a deficiency of the
hormone estrogen in females.8
Clinical Trials
Multiple clinical studies utilizing different forms of strontium have been
conducted since the 1950s. Stable strontium as gluconate, carbonate,
lactate and chloride have all been used in various trials that have reported efficacy of supplemental strontium in promoting healthy bones.
Regardless of the form, it is the elemental strontium itself that exerts the
positive effect on bone. While all of the various forms have a bioavailability of between 25 and 30%, gastric tolerance is reportedly better
with strontium citrate9, the form used in Strontium Bone Maker.
Safety
Scientific References
1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to
calcium in the remineralization of the skeleton in man. Bull Hosp
Joint Dis 1952;13:59-66.
2. Pors Nielsen S. The biological role of strontium. Bone. 2004
Sep;35(3):583-8.
3. Cabrera WE, Schrooten I, De Broe ME, D'Haese PC. Strontium and
bone. J Bone Miner Res. 1999 May;14(5):661-8.
4. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of
strontium in bone. Bone 2001;28(4):446-53.
5. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast
function and bone marrow macrophage differentiation. Eur J
Pharmacol 2002; 450:11-17.
Supplementing with strontium is an effective means for supporting
bone health and optimal bone density. When taken orally as recommended, strontium is well-tolerated and very safe. It is important to
ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals
suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.10 In rats with chronic kidney
failure, strontium has been shown to cause osteomalacia, a condition in
which bone is softened due to lack of mineral content. For this reason,
people on kidney dialysis should not use strontium supplements.11
There are no published reports of toxic effects in humans due to strontium overdosing.2
6. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and
therapeutic potential of strontium in bone. Calcif Tissue Int. 2001
Sep;69(3):121-9.
*These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
9. Genuis SJ, Schwalfenberg GK. Picking a bone with contemporary
osteoporosis management: nutrient strategies to enhance skeletal
integrity. Clin Nutr. 2007 Apr;26(2):193-207.
7. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases
vertebral bone volume in rats at a low dose that does not induce
detectable mineralization defect. Bone 1996;18(3):253-9.
8. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent contain
ing strontium prevents bone loss by depressing bone resorption
and maintaining bone formation in estrogen-deficient rats. J Bone
Miner Res 1993;8(5):607-15.
10. Grynpas MD, Marie PJ. Effects of strontium on bone quality and
quantity in rats. Bone 1990;11:313-19.
11. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes
osteomalacia in chronic renal failure in rats. Kidney Int
1998;54:448-56.
DRB • 1120 Calle Cordillera • Suite 101, San Clemente, CA 92673
phone 800-333-6977 • fax: 949-498-3952
website: www.drbvitamins.com
©Doctor’s Best, Inc.,
Revised 1/08
Supplement Facts
Strontium is a naturally occurring mineral
present in water and food. Trace amounts of
strontium are found in the human skeleton.
Strontium has an affinity for bone and is taken
up at the bone matrix crystal surface. The
influence of strontium on bone metabolism
has been researched since the 1950’s. Studies
indicate that strontium positively affects bone
metabolism to promote bone formation and
decrease bone resorption, leading to normalized
bone density.
Serving Size 2 capsules
Servings per container 30 servings
Amount per serving % Daily Value
Strontium
Dietary
Supplement
Helps maintain strong, healthy bones.*
*These statements have not been evaluated by the Food
and Drug Administration. This product is not intended to
diagnose, treat, cure, or prevent any disease.
Distributed by: Doctor's Best, Inc.
1120 Calle Cordillera, Suite 101, San Clemente, CA 92673
(800) 777-2474
www.drbvitamins.com
680 mg
†
(elemental)(from 2194mg Strontium citrate)
† Daily Value not established.
Other ingredients: modified cellulose (vegetarian capsule),
cellulose, magnesium stearate (vegetable source).
Suggested Adult Use: Take two capsules at the same time
daily with or without food. Be sure to take at least the RDI of
calcium and vitamin D3. Do not take this product at the same
time as a calcium supplement, as these minerals may compete
with each other for absorption.
Note: Individuals with severe renal impairment should check with a
health practitioner before using this product.
Suitable for vegetarians
CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS
BONE HEALTH
MAINTENANCE*
340 mg / 60 Veggie Caps
Label size: 2.25 x 6.25
Bottle size: TC-54
Designer: Neil Beltran (949) 770-0438 [email protected]