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Healing Heartburn, Naturally Top Selling Drugs in America First Quarter sales for 2012 1. 2. 3. 4. 5. Plavix (anti platelet drug) $1.6 billion Nexium (heartburn) $1.4 billion Abilify (depression) $1.34 billion Singulair (asthma) $1.24 billion Seroquel (bipolar disorder) $1.16 billion $6.74 billion Also In the News This Week: NASA Sends exploration Rover to Mars at a cost of $2.5 billion. Critics thought this was a lot of money! Antacids/Acid Blockers Antacids neutralize stomach acid Acid Blockers stop or reduce acid production in the stomach Also Available: Nexium for Kids • In 2008, FDA approved Nexium to treat GERD (gastroesophageal reflux disease) in kids as young as 12 months old • Most common side effects in children: – Headache, diarrhea, abdominal pain, nausea, gas, constipation, dry mouth, sleepiness Stomach acid is not the enemy! • Do you know what happens when you take away stomach acid? – Food is not digested properly, especially protein • Interferes with calcium, B12 and iron absorption • One study documented over 40% reduction in calcium absorption when taking Prilosec • Undigested protein in the intestines can act as allergens • Increased risk of bacterial and viral exposure • What does this mean for you? • Taking an acid-blocker or acid reducing medication can cause more problems than it “cures” Still Not Sure about Acid Blockers? • Recent study results: – women taking acid blockers 25% more likely to break a bone – Women with hip fracture are 62% more likely to have used acid blockers long term – Elderly patients using acid blockers were 2.5 times more likely to have memory problems • Probably due to poor absorption of B12 – 30% increased risk of pneumonia – 50-75% more likely to contract bacterial infection when hospitalized for other problems Is Too Much Stomach Acid Really Your Problem? • No! • Many people UNDER produce stomach acid • Too much acidic food and too little stomach acid… – Food isn’t breaking down properly – Fills up the stomach and ferments, which causes – HEARTBURN How To Repair Digestion Without Turning Off Stomach Acid D-limonene • Found in the peels of citrus fruits – orange/lemon smell is due to d-limonene • Medicinal properties – Anticancer – Relieves heartburn D-limonene: How Does it Work? • Coats the Esophagus – minor burps carry d-limonene from the stomach to the esophagus; protects it against caustic contents that would have otherwise been regurgitated from the stomach • Stimulates digestion – Stomach contents move into the intestines promptly – less likely to reflux back out of the stomach so that these esophageal irritants do not promote as much reflux. • Protects the stomach lining – provides a barrier in the stomach and esophagus against bacterial infection (H. pylori bacteria) • Reduces the amount of gastric juices that reflux back into the esophagus Clinical Research • Adults with a history (at least 5 years) of mild to moderate symptoms of heartburn or GERD • At beginning of study, rated their pain as a 5 on a 10 point scale (1 = pain free, 10 = severe pain) • By the second day of taking D-limonene, 32% of the participants experienced symptom relief, rating their pain at 1 or 2. • After 14 days, 89% of the participants were symptom free! • In a second, double-blind, placebo-controlled study, 13 participants followed the same symptom severity scale – Day 4: 29% in the D-limonene group experienced significant relief (a 1 to 2 rating), versus zero in the placebo group – Day 14: 86% of the D-limonene group reported complete relief Sea Buckthorn • Edible berries are “nutrient bombs” – More than 200 bioactive compounds – Omega fatty acids, including omega 7 • Relieves dryness and reduces inflammation • Regenerates skin and mucous membranes – Mucous membranes line the stomach and intestines Clinical Research • Peptic ulcer – Patients took sea buckthorn oil (capsules) for one month – 76% of participants experienced significant healing of their ulcers – Overall effectiveness rate was 96% – Sea buckthorn oil accelerated the healing process of damaged tissues Additional Support for Healing Digestion: DGL • Deglycyrrhizinated Licorice – Glycyrrhizin, which can cause adverse effects when licorice is used at high doses, has been removed • Works against H. pylori – H. pyloria damages the lining of the stomach/intestines • Protects against the damaging effects of aspirin and ibuprofen • Helps protect against ulcers and speed their healing Licorice (Glycyrrhiza glabra ) Clinical Results • Specialized DGL – does not have to be chewed – Effective at a smaller dosage • Randomized, double-blind, placebo controlled trial • Individuals with dyspepsia (upset stomach or indigestion) received 75mg or 150 mg of the special DGL twice daily • At 15 days and again at 30 days, participants in both DGL groups showed significantly decreased symptoms, including reduced heartburn, early satiety (that uncomfortable feeling of being “overfull” even at the beginning of a meal), regurgitation, nausea, and bloating. Ravindra KR. Efficacy of an extract of Glycyrrhiza glabra in patients with functional dyspepsia: a randomized, double blind, placebo controlled study. Bangalore, India. 2010. Probiotics • Friendly bacteria • Suppress the growth of harmful bacteria such as H. pylori • Prevent H. pylori from adhering to the lining of the intestinal tract • Increase healing rate of ulcers and strengthen the gastric mucosa • Key strains: Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium lactus, Bifidobacterium bifidum Lactobacillus acidophilus Additional Benefits • Reduce gas and bloating • Decrease risk of cancer (especially colon cancer) • Helps alleviate constipation/diarrhea Betaine HCl • Can be used to increase acidity of the stomach • Take with meals to promote digestion, especially protein digestion • Start small and increase the dosage gradually… Digestive Enzymes • Naturally produced in the body • Additional, animal-sourced, enzymes can relieve many common digestive problems when taken with meals – Reduce: gas, bloating, indigestion, heartburn, constipation and diarrhea • Taken between meals, enzymes can aid in reducing inflammation and are beneficial for arthritis and cancer Recap • To treat heartburn: – Restore stomach acidity with Betaine Hydrochloride – Reduce symptoms with D-limonene and sea buckthorn oil • Heal ulcers and treat H. pylori with DGL and probiotics • Take enzymes to meals to relieve other common digestive problems