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Dear editorial board of CARDIOLOGY JOURNAL
Please find the manuscript: “Allogeneic mononuclear cells from human umbilical
cord blood transplantation for chronic postinfarction heart failure: A 6-year follow-up
study ” by Li-zhu, et al., to be submitted as a research article to CARDIOLOGY
JOURNAL for consideration of publication. The manuscript was modified according
to the suggestion of the reviewer point to point. This is a de novo submission.
And
the previous manuscript was 47229.
All co-authors have seen and agree with the contents of the manuscript and there
is no financial interest to report. We certify that the submission is original work and is
not under review at any other publication.
Clinical trials suggest a positive influence of autologous bone marrow mononuclear
cells on myocardial infarction (MI) and heart failure. Very few studies have
investigated the safety profile and efficacy of allogeneic umbilical cord blood
mononuclear cells (CB-MNCs) administered intravenously to patients with chronic
postinfarction heart failure. The present study reported a case of a 68-year-old man
who was diagnosed with acute MI and severe heart failure in September 2008.
Conventional drugs could not improve cardiac function 9 months post-MI. The heart
function improved significantly after intravenous injection of CB-MNCs four times in
July 2009. Echocardiography data showed a significant improvement in the indicators.
The N-terminal pro-brain natriuretic peptide (NT-pro-BNP) level significantly
reduced and was maintained at a relatively low level. The infarct size reduced by 11%.
Six years after CB-MNC therapy, the parameters such as NT-pro-BNP, 6-min
walking test, and left ventricular ejection fraction were relatively stable. This case
indicated that an intravenous injection of CB-MNCs can significantly improve left
ventricular performance, quality of life, and mortality of patients with heart failure
caused by MI.
This study was performed to assess the safety profile and efficacy of allogeneic
CB-MNCs administered intravenously to patients with chronic postinfarction heart
failure. The improvement in the heart function and the overall evaluation of vital signs
indicated that allogeneic CB-MNC transplantation is safe and effective for patients
with chronic postinfarction heart failure. This study provided the basis for more
extensive and in-depth studies in the future to assess the role of allogeneic CB-MNCs
in the treatment of chronic postinfarction heart failure.
Author Contributions
LZ collected umbilical cord, AY carried out isolation CB-MNCs. LZ, RW and YR
participated in the design of the study and performed the statistical analysis. GC
conceived of the study. All authors participated in its design and follow-up and helped
to draft the manuscript. All authors read and approved the final manuscript.
Declaration: The authors have no conflicting, interests, not supported or funded by
any funds.
We hope that the editorial board will agree on the interest of this study.
Sincerely yours,
Corresponding author: gecai,chen
Adress: 399 Hailing Road, Taizhou Renmin Hospital, Taizhou, Jiangsu Province,
China
E-mai: [email protected]
Phone number: +86-13914547274