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Capsules per container: 60 Serving size: 1 capsule Servings per container: 60 Directions for use: Take 1 (one) capsule every night before bed time. OcOc-Q-Vue - FAQ Introduction Lutein (pronounced LOO-teen) is a carotenoid, meaning a natural colorant or pigment, found in dark green leafy vegetables such as spinach, plus various fruits and corn. Egg yolks are also sources of lutein. Lutein provides nutritional support to our eyes and skin – the only organs of the body directly exposed to the outside environment. Lutein has been linked to promoting healthy eyes through reducing the risk of macular degeneration. ** Other studies suggest that a mixture of nutrients, including lutein, may provide supplemental antioxidant capacity to the eyes, helping counteract free radical damage.15 Who should take Oc-Q-Vue? • • • People who are concerned about their eye health. People suffering from dry eyes. People who are at a high risk for developing advanced AMD should consider taking Oc-QVue. Talk with your doctor about the risk of developing advanced AMD and whether taking Oc-Q-Vue is right for you. Why should I take Oc-Q-Vue? Taking lutein orally is effective for preventing lutein deficiency. OC-Q-Vue contains carotenoids Lutein and Zeaxanthin found in dark green, red and yellow vegetables and fruit. These two carotenoids work together to help maintain sharp, healthy eyesight. Located in the macula of the eye (this is the center for sharp and focused vision), Lutein and Zeaxanthin act to protect the macula by filtering out harmful light before it reaches the photoreceptors. A large number of studies indicate that dietary intake of lutein and zeaxanthin is associated with a reduced risk of cataracts and Age-related Macular Degeneration (AMD). How long does a bottle of Oc-Q-Vue last? Each bottle of Oc-Q-Vue contains 60 tablets it should last you two months. The shelf-life of Oc-QVue is 2 years from date of manufacture. Are the high dosages of these supplements safe? The AREDS study followed 3600 patients for seven years and monitored them for side effects very closely. Out of thousands of patients, some AREDS participants experience minor side effects, but no serious side effects from the supplements were found. Can I take a daily multivitamin if I am taking Oc-Q-Vue? Yes, as long as you first check with your primary care doctor and he or she approves of your taking the combination of the additional multivitamin. Can I take Oc-Q-Vue if I suffer from Diabetes, Cholesterol or high blood pressure? There are no contraindications reported regarding any of the ingredients contained in Oc-Q-Vue. Can a daily multivitamin or diet alone provide the same levels of antioxidants and zinc as Oc-Q-Vue? No. Oc-Q-Vue's levels of antioxidants and zinc are considerably higher than the amounts in any daily multivitamin, and the levels of vitamins and minerals are difficult to achieve from diet alone. Orally, lutein is used for preventing age-related macular degeneration (AMD), cataracts and retinitis pigmentosa. Age-related macular degeneration (AMD). Epidemiological evidence suggests that people who consume higher amounts of lutein in their diet have a reduced risk of developing AMD. In this study had a high baseline lutein intake and therefore might not benefit as much by further increasing lutein intake. Preliminary clinical research suggests that taking lutein supplements 10 mg per day for 12 months can improve some symptoms of AMD such as macular pigment optical density and glare recovery, near vision acuity, and contrast sensitivity. Cataracts. There are epidemiological studies that suggest a reduced risk of developing severe cataracts that require surgical removal in people consuming higher amounts of lutein in their diet. Contra Indications? Do not use if you have experience any negative side-effects with similar products or if you are sensitive to any of the ingredients as listed in the nutritional information. Warnings? Discontinue use if any unwanted side-effects are experienced and contact a health care professional as soon as possible. This product is not intended to diagnose, cure, treat or prevent any disease. Consult a health care professional if you not sure how or when to use this product or if you have a known sensitivity to any of the listed ingredients. Interactions? There are no known interactions with the ingredients at their respective dosages. If you are however being treated for any condition it is always wise to consult with your health care professional for advice before using any nutraceutical supplements. The LIB is also not aware of any adverse health reports from interactions between lutein and medications. However, the surest way to learn about possible interactions between your medication and any supplements is to consult your doctor before beginning such a regimen. The same is true for lutein. Interactions with Diseases or Conditions? CYSTIC FIBROSIS: Due to pancreatic enzyme deficiency, dietary carotenoid absorption is often decreased in patients with cystic fibrosis. These patients often have low serum levels of lutein and its stereoisomer, zeaxanthin. Lutein supplement absorption might also be decreased in the patients. Interaction with other Herbs and Supplements? Pregnancy and lactation: Pregnant or breast feeding woman should consult their doctor for advice before taking this product. SAFE when used orally and appropriately in amounts found in foods. Will taking Oc-Q-Vue prevent me from developing AMD and/or improve my vision? No. There is no known treatment that can prevent the development of AMD. The AREDS study showed that the vitamins taken supported eye health, but did not show that patients would see improvement in their vision. No vitamin or supplement has ever been scientifically proven to improve vision lost to AMD. Oc-Q-Vue is a powerful combination of carotenoids, vitamins and minerals. The main ingredients in Oc-Q-Vue is • • • • • • • Lutein Zeaxanthin Cryptoxanthin Vitamin A Vitamin C Vitamin E Zinc Lutein and EYE Health Lutein and other carotenoids are deposited throughout our skin through the lutein we consume.1 Research suggests 10 mg of lutein from food or dietary supplements may play a role in maintaining healthy skin.2, 3, 4 A recent human clinical study showed 10 mg of lutein daily increased skin hydration, elasticity and skin lipid content.5 This is the first research to show improvement in skin health through lutein supplementation alone. Skin is the largest organ of the human body. Along with our eyes, it is the only organ of the body constantly exposed to the environment. Skin is "assaulted" by • • Light (especially ultraviolet and visible wavelengths) Environmental pollutants ** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Lutein and Women's Health Research has suggested a minimum of 6-10 mg per day of lutein is necessary to realize lutein’s health benefits. One such benefit is lutein’s role in eye health, specifically its role in reducing the risk of Age Related Macular Degeneration (AMD).** In particular to women’s health, research has implicated gender as a risk factor for AMD with women at a higher risk than men. 6 It is documented that women have approximately 20% lower macular pigment in the eye compared to men.7 Women’s health research suggests lutein may also have a role during pregnancy and lactation. Researchers have found lutein and zeaxanthin in breast milk and umbilical cord plasma, suggesting that these carotenoids may be transferred from mothers to babies.8, 9 In addition, studies indicate that foods rich in carotenoids - lutein, zeaxanthin, lycopene, betacarotene, alpha-carotene - may have protective benefits against breast cancer risk.**10-13 ** These statements have not been evaluated by the Medicine Control Council of South Africa. This product is not intended to diagnose, treat, cure, or prevent any disease. Why is lutein important in our diet? Simply put, lutein is an antioxidant that appears to quench or reduce harmful free radicals in various parts of the body. ** Free radicals can play a role in a variety of chronic diseases. Lutein also filters the high-energy, blue wavelengths of light from the visible-light spectrum by as much as 90%.16 Blue light, in both indoor lighting and sunlight, is believed to induce oxidative stress and possible free-radical damage in human organs exposed to light, such as the eyes and skin. Blue light is not the same as the commonly known ultraviolet A and ultraviolet B wavelengths of the invisible spectrum. How much lutein do we need? Research suggests a minimum of 6-10 mg per day of lutein from dark green leafy vegetables and other sources is necessary to realize lutein’s health benefits. Even if you eat a balanced diet, you’d need a large bowl of fresh spinach to get about 6 mg of lutein. Most Americans just don’t consume enough foods rich in lutein. Lutein is widely available in a variety of nutritional supplements and fortified foods and beverages for people wanting to supplement their dietary intake of lutein, making their diet even better for their eyes. Research Findings 1. Gonzalez, S., Astner S., et al. (2003). "Dietary lutein/zeaxanthin decreases ultraviolet B-induced light epidermal hyperproliferation and acute inflammation in hairless mice." J Invest Dermatol 121: 399-405. 2. Van de Leun, J.C. (1996). "UV Radiation from Sunlight: Summary, Conclusions, and Recommendations." J Photochem. Photobiol. B: Biol. 35: 237-244. 3. Podda, M., Traber, M.G., et al. (1998). "UV-Irradiation depletes antioxidants and causes oxidative damage in a model of human skin." Free Rad. Biol. Med. 24: 55-65. 4. Morganti, P., Bruno, C., et al. (2002). "Role of topical and nutritional supplement to modify the oxidative stress." International J Cosmetic Science 24:331-339. 5. Morganti P., Palambo, P., et al. (2006). "New Evidence for Efficacy of Lutein/Zeaxanthin in Skin Health." Beyond Beauty Paris 2006 Conference Abstract. 6. (2000). “Risk factors associated with age-related macular degeneration. A case-control study in the age-realted eye disease study: Age-Related Eye Disease Study Report Number 3.”Ophthalmology 107: 2224-32. 7. Richer, S. (2005). “Gaining ground in the war on AMD.” European lenses and technology Oct-Nov: 6-10. 8. Scheigert F.J., Bathe K., et al. (1998). “Effect of the stage of lactation in humans on carotenoid levels in milk, blood plasma and plasma lipoprotein fractions.” Eur J Clin Nutr 52: 754-759. 9. Yeum, K. J., Ferland, G., et al. (1998). "Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants." J Am Coll Nutr 17(5): 442-7. 10. Peng, Y.M., Peng, Y.S., et al. (1993). "A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human issues." Cancer Epidermiol Biomarkers Prev 2:139-144. 11. Kim, M.K., Park, Y.G., et al. (2002). "Breast cancer, serum antioxidant vitamins, and p53 protein overexpression." Nutr Cancer43:159-166. 12. McMillan, D.C. Talwar, D., et al. (2002). "The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours." Clin Nutr 21:161-164. 13. Sato, N., Helzlsouer, K., et al. (2002). "Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer." Cancer Epidermiol Biomarkers Prev 11: 451-457. 14. Morganti Morganti, P., Bruno, C., et al. (2002). "Role of topical and nutritional supplement to modify the oxidative stress." International J Cosmetic Science 24:331-339. 15. Krinsky, N.I., et al., (2003). “Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye.” Annu. Rev. Nutr. 23: 71-201. Scientific References Palombo P, Fabrizi G, Ruocco V, Ruocco E, Flühr J, Roberts R, Sousa-Martins D, and Morganti P. New Evidence for Efficacy of Lutein/Zeaxanthin in Skin Health. Beyond Beauty Paris 2006 Conference Abstract, 2006. 2006 Rerksuppaphol, S; Rerksuppaphol, L. 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Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblasts. Photochem Photobiol. 2002 May;75(5):503-6. 2002 Bruch-Gerharz D, Stahl W, Gerharz CD, Megahed M, Wingerath T, Sies H, Ruzicka T. Accumulation of the xanthophylls lutein in skin amyloid deposits of systemic amyloidosis (AL type). J Invest Dermatol. 2001 Jan;116(1):196-197. 2001 Nagao T, Warnakulasuriya S, Ikeda N, Fukano H, Yamamoto S, Yano M, Miyazaki H, Ito Y. Serum antioxidant micronutrient levels in oral lichen planus. J Oral Pathol Med. 2001 May;30(5):264-7. 2001 Lee J, Jiang S, Levine N, Watson R. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc Soc Exp Biolog Med. 2000 223:170-174. 2000 Hata TR, Scholz TA, Ermakov IV, McClane RW, Khackik F, Gellermann W, Pershing LK. Non-invasive raman spectroscopic detection of carotenoids in human skin. 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J Dermat Sci. 1998 16:226-230. 1998 Rocchi E, Stella AM, Cassanelli M, Borghi A, Nardella N, Seium Y, Casalgrandi G. Liposoluble vitamins and naturally occurring carotenoids in porphyria cutanea tarda. Eur J Clin Invest. 1995 Jul;25(7):510-4. 1995 Peng YM, Peng YS, Lin Y. A nonsaponification method for the determination of carotenoids, retinoids, and tocopherols in solid human tissues. Cancer Epidemiol Biomarkers Prev. 1993 Mar-Apr;2(2):139-44. 1993 Peng YM, Peng YS, Lin Y, Moon T, Baier M. Micronutrient concentrations in paired skin and plasma of patients with actinic keratoses: effect of prolonged retinol supplementation. Cancer Epidemiol Biomarkers Prev. 1993 Mar-Apr;2(2):145-50. 1993 Nierenberg DW, Nann SL. A method for determining concentrations of retinol, tocopherol, and five carotenoids in human plasma and tissue samples. Am J Clin Nutr. 1992 Aug;56(2):417-26.