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P.O. Box 144345 Austin, TX 78714-4345 § 512.926.4900 § Fax: 512.926.2345 § www.herbalgram.org HerbClip™ Christina Chase, MS, RD Heather S Oliff, PhD Michelle Schuman Sanger Jill Hoppe Diane Graves, MPH, RD Mariann Garner-Wizard Densie Webb, PhD Executive Editor – Mark Blumenthal Consulting Editor – Don Brown, N.D. Managing Editor – Lori Glenn Funding/Administration – Wayne Silverman, PhD Production – George Solis/Kathleen Coyne FILE: § Dietary Supplements § Market performance HC 032325 - 216 Date: September 24, 2002 RE: Specific Nutritional and Botanical Ingredients Expected for Increased Sales Success Wagner J. Ingredients to Watch in 2002. Nutritional Outlook. Jan/Feb 2002; 5(1):18-20, 22-25. Nutritional Outlook Editor Jim Wagner found a silver lining for nutritional supplements, after cloudy 2001 sales, through examining new ingredients, new research on and methods of delivery for established ones, money saving manufacturing methods, process and product patents, and advertising commitments. According to Information Resources Inc. (Chicago, IL), sales of supplements were down 6.6%, vitamins fell 9.4%, and herbal products decreased 19.6% in 2001, as compared with 2000 in mainstream retail markets. At the same time, nonherbal supplements (e.g., glucosamine/chondroitin, flaxseed oil, acidophilus, amino acid products) rose 5.6%, multinonherbal formulas increased 23.2%, magnesium was up 18.5%, and antioxidant multivitamins were up 23.7%. For 2002, trace elements should be strong, with new research driving the increase. Institut Rosell Lallemand (Montreal, Can) and the International Association of Bioinorganic Scientists held the first international symposium on biominerals in 2001, where study results presented showed links between zinc, copper, selenium, and other minerals, and cancer, cardiovascular health, mental health, AIDS, and diabetes. Institut Rosell has also developed ingredients with bioavailable iron and iodine. Knowledge is spreading that lycopene, the major carotenoid in tomatoes (Lycopersicum esculentum), can protect against oxidative damage. Recent studies link it to reduced risks of breast cancer, prostate cancer, and infection by certain viruses. A standardized tomato extract, Lyc-O-Mato®, made by LycoRed (Beersheba, Israel) and distributed by LycoRed-Biodar (New York, NY), used in some cancer studies, is up for Food and Drug Administration consideration as a food coloring additive. Major food companies are reportedly considering including lycopene in several products. (It is already present in naturally-occurring levels in food products containing tomatoes, watermelon, and grapefruit.) New research is looking at supplements as alternatives to prescription drugs or as methods to delay their use in cholesterol management. Niacin has been shown to increase high-density lipoprotein (HDL) cholesterol while lowering triglycerides. A form of potassium hydrogen d-glucarate has been shown in animal trials to reduce total serum cholesterol up to 14%, lowering low-density lipoprotein (LDL) levels by as much as 35%. Preventium®, a patented natural compound from Glucona America (Janesville, WI) and developed by BioChemix, Inc. (Austin, TX), has been shown to reduce serum cholesterol in rats fed high-fat diets. Tocotrienols, particularly alphatocotrienol, may emerge as alternatives to cholesterol-lowering prescription drugs. In addition to reducing serum cholesterol, tocotrienols protect neurons from oxidative damage. Lutein is poised for a sales explosion. The number of people at risk for macular degeneration (nearly one in three over age 75), as well as research results showing the carotenoid's benefits, virtually guarantee big demand. Two forms of lutein are marketed: lutein esters and crystalline lutein. Lutein esters are found in orange and yellow fruits and in red and yellow peppers, but marigolds (Calendula officinalis) are most commonly associated with them. FloraGLO® lutein (Kemin Foods, Des Moines, IA), from marigolds, is the only lutein "generally recognized as safe" (GRAS) for certain food and beverage applications and will appear in several foods and beverages in 2002. FloraGLO® lutein is used in American Home Products' popular Centrum® multivitamins. Several other multivitamins are being reformulated with lutein. A three-year shelf life study showed that Xangold® lutein esters (Cognis Nutrition and Health, La Grange, IL) reduced manufacturing waste. In addition, Cognis is building the world's largest stand-alone manufacturing plant for phytosterols which will be built to good manufacturing practice (GMP) standards for foods near Toulouse, France. The plant's capacity will be 1600 metric tons yearly. In other manufacturing news, Specialty Minerals (Bethlehem, PA) has developed a form of directly compressible calcium carbonate, a common supplement excipient. The new material reduces tablet size and volume, eliminates the need for binders and lubricants, and improves disintegration while reducing friability. Herbal products are difficult to compress and many need excipients. Redi Run DC™, from the strategic partnership of Penwest (Patterson, NY) and Finzelberg (Andernach, Germany), makes botanicals easier to compress, reducing tablet size up to five times. By the end of 2001, two products had been introduced by the partnership: HyperFin DC™, with 300 mg of St. John's wort (Hypericum perforatum) in a 450 mg tablet, 66% smaller than conventional products; and Panax Fin DC™, with 500 mg of Asian ginseng (Panax ginseng) in a 752 mg tablet, 86% smaller than most ginseng tablets. Performance and weight loss products, always strong, should continue to rise in 2002. Excelatine, from Nutritional Sourcing Inc. (Edison, NJ) combines carnitine and creatinine for more efficient energy use. Magnesium creatine chelate from Albion Laboratories (Clearfield, UT) is another potential performance enhancer. New research on obesity and health is expected to give supplements aimed at body mass an advantage over other weight loss products. ForsLean® (Sabinsa Corp., Piscataway, NY), new product of the year at Nutracon 2001, is a composition extract from the root of Coleus forskohlii, standardized to 10% forskolin. Forskolin activates an enzyme that helps induce thermogenesis. For appetite control, Triarco (Wayne, NJ) has high hopes for its Serotain™, providing natural 5-hydroxytryptophan (5-HTP) from Griffonia simplicifolia, used in Europe for over 20 years. The author rounds out this survey with notable developments pointing to renewed interest in supplements. These include research showing the safety of Glycomarine® glycogen complex, an anti-inflammatory for arthritis pain derived from New Zealand green-lipped mussels (Perna canaliculus) and new uses for encapsulation to protect ingredients during processing. Prototypes with encapsulated ingredients include nutrient bars with choline, flaxseed (from Linum usitatissimum), and folic acid; chocolate bars with probiotics; and nutrient bars with vitamin C, ferrous sulphate, and guarana (Paullinia cupana or P. sorbilis). Research supporting the heart-healthy action of long-chain omega-3 fatty acids, derived from fish oil or algae, is backed by new technology to convert fish oil to powder. A new food safety additive from milk, activated lactoferrin, will help protect meat from harmful bacteria, while research into its uses continues in a joint venture of Farmland Natural Beef Packing Co (Kansas City, MO) and DMV USA (a division of DMV International, Delhi, NY). Salibra bioactive colostrum, an immune system enhancer from Glanbia Ingredients (Monroe, WI), uses proprietary processes to ensure efficacy and bioactivity. Finally, Ester-C®, a nonacidic, patented form of vitamin C from Inter-Cal Nutraceuticals (Prescott, AZ), will be advertised nationally as a branded supplement in a $9.5 million campaign. Mariann Garner-Wizard Enclosure: Copyright ©2002, Nutritional Outlook (www.nutritionaloutlook.com), reprinted with permission. All rights reserved. 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