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Download Astatine isotopes in medicine At is known to accumulate in the
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Stable isotope (none) Relative atomic mass Mole fraction Astatine isotopes in medicine 211 At is known to accumulate in the thyroid and occasionally is the preferred treatment for hyperthyroidism and thyroid cancer because the particles emitted from 211 At provide more energy than radiolabeled iodine, the other treatment method (Figure 1). However, astatine has shown a tendency to induce tumors, so its use is limited [574-576]. The 211 At-labeled dicarborane (cluster of boron, carbon, and hydrogen atoms) ligand known as the Venus Flytrap Cluster (VFC) is being investigated for use as a robust pharmaceutical in radiotherapy treatment [574-576]. Fig. 1: 211 At treats hyperthyroidism and thyroid cancer. (Image Source: © 2012 Terese Winslow LLC, U.S. Govt. has specified rights) [577]. Glossary hyperthyroidism – too much thyroid hormone is produced in the body. [return] ligand – the atoms or groups joined to the central atom [703]. [return] radiolabeled – a mixture of an isotopically unmodified compound with one or more analogous radioactive isotopically substituted compound(s). [return] radiotherapy (radiation therapy) – the treatment of disease by means of radiation from radioactive substances or X-rays. [return] X-rays – electromagnetic radiation with a wavelength ranging from 0.01 to 10 nanometers— shorter than those of UV rays and typically longer than those of gamma rays. References 574. L. M. Cobb, Harrison, A., Dudley, N.E., Carr, T.E.F., and Humphreys, J.A. Radiotherapy and Oncology. 13 (3), 203 (1988). 575. N. R. C. Canada. Periodic Table of the Elements: Astatine. National Research Council Canada. 2014 Feb. 25. http://www.nrc-cnrc.gc.ca/eng/education/elements/el/at.html 576. T. J. Gullon. In Chemistry. McMaster University (2010). 577. T. Winslow. (T. A. P. G. Anatomy, ed.). National Cancer Institute at the National Institutes of Health (2012). 703. I. U. o. P. a. A. Chemistry. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications, Oxford (1997).
