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Chapter 9
MITOSIS
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
9.1 The Cell Cycle
**Orderly set of steps between eukaryotic cell divisions
Why do Cells Divide?
Growth
Reproduction
(in single celled organisms)
Repair
a. ________________
b. ________________
c. _________________
d. _________________
e. _________________
f. __________________
f.
Control of the Cell Cycle
G1 Checkpoint - Check to see if DNA is damaged
G2 Checkpoint - Check to see if DNA is replicated properly
M Checkpoint - spindle assembly checkpoint, check for alignment of chromosomes
Apoptosis - programmed cell death, if any of the checks fail
9.2 Mitosis & Cytokinesis
Mitosis - The division of the nucleus that results in identical
complete copies of chromosmes packaged into two new nuclei
Cytokinesis - The division of the cytoplasm that results in two
daughter cells
Interphase • Prophase • Metaphase • Anaphase • Telophase
IPMAT
Interphase: Resting
Prophase: Chromosomes visible, spindle forms as centrioles
move
Metaphase: Chromosomes line up along equator
Anaphase: Chromatids separate
Telophase: Nuclear membrane forms on each side, cytokinesis
**In plant cells, cytokinesis begins when a new cell wall forms between the two
new cells.
**In animal cells, the two new cells pinch and pull apart
9.3 The Cell Cycle and Cancer
neoplasm: abnormal growth of cells
benign: non-cancerous
malignant: cancerous
Cancer: cellular growth disorder that results from the mutation of
genes that regulate the cell cycle
Cancer cells
● lack differentiation
● have abnormal nuclei
● form tumors
● undergo metastasis & angiogenesis
Mitosis produces 2 daughter cells
The two daughter cells contain the exact same number of
chromosomes as the original parent cell
Daughter cells are DIPLOID
HeLa Cells
A HeLa cell (also Hela or hela cell)
is a cell type in an immortal cell
line used in scientific research. It
is the oldest and most commonly
used human cell line.
The line was derived from cervical
cancer cells taken from Henrietta
Lacks, a patient who eventually
died of her cancer on October 4,
1951.
Article on Henrietta
Lacks
1. Name the phases
starting at the top.
1. Name the phase
2. Identify X
3. Identify Y
5. Name the
phase
6. Name the
phase
10. In humans, each cell (except sex cells) has how many chromosomes? ______
11. After mitosis, how many daughter cells are produced? _______
12. After mitosis (in a human cell), each daughter cell has how many chromosomes?
_____
13. How many phases are in MITOSIS? ___________