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CHF: Diagnosis of Heart Failure Reference # 210 CHF: Diagnosis of Heart Failure Key Highlights from the Recommended Guideline Diagnose heart failure when the patient has both (a) clinical evidence of impaired cardiac output and/or volume overload, and (b) abnormal systolic or diastolic function by diagnostic imaging Scope: Health professionals involved in the care of adult patients with suspected heart failure How do I diagnose heart failure accurately in a patient in whom I suspect heart failure? Establish the diagnosis of heart failure and identify modifiable risk factors by clinical examination and laboratory testing. [Level of Evidence: Class I, Level C] • The triad of edema, fatigue, dyspnea is not sensitive or specific • Patients may have heart failure o Without having volume overload o With a normal ejection fraction Some Common Precipitants Coronary artery disease, thyroid dysfunction, drugs Also consider if appropriate, rarer causes Signs and Symptoms dyspnea, orthopnea, paroxysmal nocturnal dyspnea, cough, weight gain, abdominal distension, nocturia, dependent edema, fluid overload, cool extremities Uncommon Signs and Symptoms altered mentation or cognitive impairment, nausea, abdominal discomfort, oliguria, cyanosis Perform transthoracic echocardiography to assess ventricular size and function, or if unavailable, gated radionuclide ventriculography. [Level of Evidence: Class I, Level C] Document the patient’s functional capacity using the New York Heart Association (NYHA) or another validated measure. [Level of Evidence: Class I, Level C] NYHA Classification I = No symptoms II = Symptoms with ordinary activity III = Symptoms with less than ordinary activity IV = Symptoms with minimal activity or at rest o A 6 minute walk test may be helpful Screen first-degree relatives if the patient has a family history of cardiomyopathy or sudden death. [Level of Evidence: Class I, Level C] www.gacguidelines.ca -1- CHF: Diagnosis of Heart Failure Reference # 210 What if you suspect that coronary artery disease is contributing to the heart failure? Consider coronary angiography. [Level of Evidence: Class I, Level C] o Radionuclide imaging, cardiopulmonary exercise testing may also be helpful What if you are uncertain of the clinical diagnosis? Consider testing levels of plasma B-type or brain natriuretic peptides (BNPs). [Level of Evidence: Class IIa, Level A] Consider measuring BNP in patients with an established diagnosis of heart failure for prognostic stratification. [Level of Evidence: Class IIa, Level A] Consider measuring BNP sequentially to guide the therapy of patients with heart failure. [Level of Evidence: Class IIb, Level B] Levels of Evidence Class I Class II Class IIa Class IIb Class III Level A Level B Level C Evidence or general agreement that a given procedure or treatment is beneficial, useful and effective. Conflicting evidence or a divergence of opinion about the usefulness or efficacy of the procedure or treatment. Weight of evidence is in favour of usefulness or efficacy. Usefulness or efficacy is less well established by evidence or opinion. Evidence or general agreement that the procedure or treatment is not useful or effective and in some cases may be harmful. Data derived from multiple randomized clinical trials or meta-analyses. Data derived from a single randomized clinical trial or nonrandomized studies. Consensus of opinion of experts and/or small studies. The above recommendations were derived from the following GAC endorsed guidelines: Arnold, J.M.O., Liu, P., Demers, C. et al. and the Canadian Cardiovascular Society. (2006, January). Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: Diagnosis and management. Canadian Journal of Cardiology, 22(1), 23-45. Arnold, J.M.O., Howlett, J.G., Dorian, P., Ducharme, A., Giannetti, N., Haddad, H. et al. (2007, January). Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers. Canadian Journal of Cardiology, 23(1), 21-45. Rating (out of 4): Endorsed Date: May, 2007 Planned Review Date: July, 2009 Ontario Guidelines Advisory Committee 500 University Ave., Suite 650 Toronto, ON M5G 1V7 Telephone: 1-888-512-8173 Fax: 416-971-2462 Email: [email protected] www.gacguidelines.ca -2-