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MLT 2254 – Clinical Chemistry (Enzymes and Proteins of all major Organs of the human body) Course Philosophy This course, Clinical Chemistry, is the third of five major courses in the Medical Laboratory Technology curriculum. This course is designed to prepare students to perform routine and complex laboratory testing procedures as they pertain to the study of metabolic processes that maintain chemical homeostasis in humans. Additionally, this course provides the interpretation of assay values in evaluating chemical patient profiles with an emphasis on correlating abnormal results with metabolic dysfunction and/or disease states. A minor emphasis is placed upon Toxicology, Instrumentation, and Extensive Westgard rules. This course teaches enzymology along with clinical significance, and appropriate recommendations and/or corrective actions of quality control and assurance (QA/QC) protocols. In addition, this course provides a hands-on approach to laboratory experiences, and is primarily an undergraduate sophomore level course. Basic assumptions are made with regard to content from both MLT 1203, MLT 2213, MLT 2234, ZOOL 1014, and CHEM 1014. Course emphasis and outcomes rest with the ability of the student to properly perform a Manual Spectrophotometric Determination of an Analyte, with a comparative percent error calculated using Automated Instrumentation in the Student laboratory in a timely manner without assistance. (MLT 2234 – Clinical Hematology is the prerequisite course) Course Content Course Objectives Carbohydrates / Acid-Base / Electrolytes 1. Calculate the Anion gap, Osmolality, and the Osmolal gap with an 80% accuracy. Proteins and Non-Protein Nitrogen (NPN) Enzymes / Lipids / Lipoproteins Endocrinology/Hormones 2. Explain the concepts of Therapeutic Drug Monitoring (TDM) and Arterial Blood Gases (ABG) along with affective factors associated within a 75% accuracy. Special Chemistry 3. Identify the components of a Basic Metabolic profile with a 100% accuracy. Case Studies and Content Presentations 4. List and Explain the clinical significance of the major enzymes studied with a 80% accuracy. Course Teaching Requirements Bishop, M. L., Fody, E. P., & Schoeff, L. (2009). Clinical Chemistry: Principles, Procedures, Correlations, 6th ed. Lippincott, Williams, & Wilkins: Philadelphia Major Emphasis: Chapters: Review of General Chemistry & Chapter 1, 3, 4, 8-14, 17-21, 22, 24, 28, & 30. Minor Emphasis: Chapters: 2, 5, 6-7, 15, 16, 23-27, 29, 31-33. Final Examination is usually given the second Friday from Hospital Rotation – per NAACLS time between last scheduled examination, usually accounts for 15% of final grade calculation. Assessment Responsibilities Instructors teaching this course will be expected to participate in assessment activities as dictated by the Division of Advanced Technology & Allied Health. The Lead instructor for this course will provide further information and/or instructions, during the term in which assessments are completed. Division of Advanced Technology & Allied Health Contact information: Division Chair: Mr. Keith McClanahan, 501-882-8822, [email protected] Lead Instructor: Mr. Jimmy L. Boyd, 501-882-8814, [email protected] Online Course Monitor: Not Applicable