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Unit 1 Analyze the nervous system and explain its structure and dynamics Explain the basic structure and function of the central nervous system. Include: (i) brain (ii) spinal cord Which structures in the diagram below belong to the central nervous system? (A) W and X (B) W and Z (C) Y and X (D) Y and Z Which structure is part of the central nervous system? (A) heart (B) skin (C) spinal cord (D) thyroid gland Explain how the nervous system is protected. Include: (i) skull (ii) meninges (iii) cerebrospinal Explain the basic structure and function of the Include: (i) cerebrum (ii) cerebellum (iii) medulla oblongata (iv) thalamus (v) hypothalamus (vi) midbrain (vii) pons (viii) corpus callosum Which part of the brain controls hunger, body temperature, and aggression? (A) cerebellum (B) cerebrum (C) hypothalamus (D) thalamus Which part of the brain controls movement that is an automatic, involuntary reaction to a stimulus? (A) cerebellum (B) cerebrum (C) hypothalamus (D) thalamus If a person is unable to walk straight, which part of the brain is most likely damaged? (A) cerebellum (B) cerebrum (C) medulla (D) thalamus Which region of the brain below controls reflex actions, such as hiccuping and vomiting? (A) W (B) X (C) Y (D) Z Describe the basic functions of a peripheral nervous system. Include: (i) autonomic - sympathetic - parasympathetic (ii) somatic Which division of the nervous system is directly responsible for physiological responses to fear? (A) parasympathetic (B) sensory (C) somatic (D) sympathetic What effect does a somatic nervous system stimulant have on the human body? (A) decreases the sensitivity of the postsynaptic membrane to acetylcholine (B) increases the sensitivity of the postsynaptic membrane to acetylcholine (C) makes the membrane permanently impermeable to potassium (D) makes the membrane permanently impermeable to sodium Which best describes the response of a human’s autonomic nervous system after an emergency situation? Sympathetic parasympathetic (A) inhibition inhibition (B) inhibition stimulation (C) stimulation inhibition (D) stimulation stimulation Explain how the nervous system helps to maintain homeostasis – identify requirements necessary for a nervous response to occur. Include: (i) sensory receptors (skin, eye, ear) (ii) impulse transmission (neurons) (iii) interpretation and analysis of impulses (brain, spinal cord) (iv) effectors (muscle, gland) Describe the structure of the typical neuron and explain the function of each part. Include: (i) dendrite (ii) cell body (iii) axon (iv) axon terminal (v) Schwann cells (myelin sheath and nodes of Ranvier) Which part of a neuron is the site for receiving signals from other neurons? (A) axon (B) dendrite (C) myelin sheath (D) Schwann cells Which region of the neuron below enhances the rate of impulse transmission? (A) A (B) B (C) C (D) D Describe the function of sensory neurons, motor neurons and interneurons Describe the transmission of an impulse along the length of a neuron. Include: (i) the ion distribution of the neural membrane (rest, depolarization, repolarization) (ii) threshold (iii) action potential (iv) all-or-none response What is the normal ion distribution outside the neural membrane when a neuron is at rest? K+ concentration (A) high (B) high (C) low (D) low Na+ concentration high low high low What happens to the gates of the potassium ion (K+) and sodium ion (Na+) channels when a neuron is stimulated above its threshold? K+ gates Na+ gates (A) close close (B) close open (C) open close (D) open open In which direction does an action potential normally travel along an axon? (A) away from the cell body (B) away from the synapse (C) from myelin to dendrites (D) from myelin to nucleus What initiates the action potential in a nerve? (A) influx of calcium ions into the axon (B) influx of sodium ions into the axon (C) outflow of calcium ions from the axon (D) outflow of sodium ions from the axon Explain how the nervous system helps to maintain homeostasis Describe the transmission of an impulse across a synapse and the effects of neurotransmitters involved. Include: (i) acetylcholine (ii) noradrenaline (iii) glutamate (iv) GABA (v) dopamine (vi) serotonin Which neurotransmitter stimulates skeletal muscles but inhibits cardiac muscles? (A) acetylcholine (B) dopamine (C) glutamate (D) seratonin In the diagram below an impulse travels from V to W but not from W to Y. Which best explains why there is no transmission from W to Y? (A) Acetylcholine caused an excitatory response at Z. (B) Acetylcholine caused an inhibitory response at Z. (C) Noradrenaline is inhibited at Y. (D) Noradrenaline is stimulated at Y. Describe the critical role of cholinesterase in nerve transmission • identify the role of certain compounds to neuron function (oxygen, glucose, ATP, sodium ions) Analyze homeostatic phenomena to identify the feedback mechanisms involved – define reflex arc Perform an experiment to investigate and collect data on the nervous system (reflexes) and identify specific variables involved Describe disorders linked to the nervous system and their effect on homeostasis of the system and the organism as a whole. Include: (i) Multiple Sclerosis (ii) Alzheimer’s Disease (iii) Parkinson’s Disease (iv) Meningitis (v) Huntington’s Disease Which part of the nerve cell is affected most by multiple sclerosis? (A) axon (B) cell body (C) dendrites (D) myelin sheath What causes meningitis? (A) bacterial or viral infection (B) death of neurons that produce dopamine (C) degeneration of neurons in the brain (D) inflammation of the myelin sheath Which disorder affects the movement of skeletal muscles due to a dopamine deficiency? (A) Alzheimer’s (B) Huntingon’s (C) Multiple Sclersosis (D) Parkinson’s Analyze why and how technologies related to the treatment of nervous system disorders were developed and improved over time – include the technologies: (i) MRI (ii) EEG (iii) CAT Scan (iv) PET Scan – describe the methods used to treat stroke and spinal cord injury Describe how the use of prescription and nonprescription drugs can have a role in maintaining or disrupting homeostasis Include: (i) anaesthetics (ii) prescription drugs (OxyContinTM, ValiumTM, RitalinTM) (iii) illegal drugs (marijuana, ecstasy, cocaine) (iv) legalized drugs (alcohol, nicotine, caffeine) Which is a depressant? (A) alcohol (B) caffeine (C) cocaine (D) nicotine Distinguish between questions that can be answered by science and those that cannot and between problems that can be solved by technology and those that cannot Propose courses of action on social issues related to science and technology, taking into account an array of perspectives, including that of sustainability. Explain how the eye as a sense organ helps maintain homeostasis – describe the general structure and function of the eye. Include: (i) lens (ii) iris (iii) retina (iv) cornea (v) choroid layer (vi) fovea centralis (vii) rods (viii) cones (ix) pupil (x) blind spot (xi) optic nerve (xii) aqueous humour (xiii) vitreous humour Which part of the eye is responsible for absorbing light and preventing internal reflection? (A) choriod (B) cornea (C) iris (D) retina Which part of the human eye is considered to be an adaptation for living in a low light environment? (A) cones (B) iris (C) retina (D) rods Trace the path of light through the eye and explain how the amount of light entering the eye is regulated What is the sequence through which light passes on its way to the retina of the human eye? (A) cornea ÷ pupil ÷ lens ÷ retina (B) cornea ÷ lens ÷ pupil ÷ retina (C) pupil ÷ cornea ÷ lens ÷ retina (D) pupil ÷ lens ÷ cornea ÷ retina Analyze and describe examples of disorders of the eye and where technologies for the correction of visual defects were developed based on scientific understanding Include: – eye disorders (glaucoma, cataracts, astigmatism, myopia, hyperopia) – treatments for the eye disorders (corneal transplant, laser surgery, corrective lenses, lens replacement) Explain how the ear as a sense organ helps maintain homeostasis – describe the general structure and function of the ear. Include: (i) pinna (ii) tympanic membrane (iii) ossicles (i.e., malleus, incus, stapes) (iv) eustachian tube (v) semi-circular canals (vi) cochlea (vii) auditory nerve Which part of the human ear is involved in hearing? (A) cochlea (B) eustachian tube (C) semicircular canals (D) vestibule Which ear structure maintains balance? (A) cochlea (B) malleus (C) semicircular canals (D) tympanic membrane Which structure of the human ear allows air pressure to equalize? (A) cochlea (B) eustachian tube (C) hammer (D) semi-circular canal Trace the pathway of sound through the ear Analyze and describe examples of disorders of the ear and where technologies for the correction of auditory defects were developed based on scientific understanding – ear disorders – conduction deafness, nerve deafness – treatments for ear disorders - eustachian tube implants, hearing aids What is the best way to treat a child with repeated middle ear infections due to fluid build-up behind the ear drum? (A) Administer antibiotics for several years. (B) Implant eustachian tubes. (C) Prepare the child for the loss of hearing. (D) Provide a hearing aid. Evaluate, considering ethical issues, the consequences of medical treatments for visual and auditory disorders – sense of exclusion – mandatory organ donation Explain how the endocrine system helps maintain homeostasis – understand the general concept of a hormone and target cell or organ What distinguishes target cells from other cells? (A) amount of cellulose in cell membrane (B) amount of phospholipids in cell membrane (C) hormone-specific cell surface receptors (D) hormone-specific cytoplasmic receptors Compare how non-steroid and steroid hormones cause changes in target cells. Include: (i) solubility in cell membrane (ii) location of receptors (iii) end result – identify the location and function of principal endocrine glands in the human organism. Include: (i) pituitary (ii) hypothalamus (iii) pineal (iv) thyroid (v) parathyroid (vi) adrenal (vii) pancreas (Islets of Langerhans) (viii) thymus (ix) ovaries (x) testes Which gland secretes melatonin? (A) lacrimal (B) pineal (C) pituitary (D) sweat Which gland controls calcium levels in blood? (A) adrenal (B) pineal (C) thymus (D) thyroid Which gland produces and releases a thyroid-stimulating hormone? (A) anterior pituitary (B) hypothalamus (C) posterior pituitary (D) thyroid Which gland in the diagram below is responsible for controlling metabolism in the heart, liver, kidney, and muscle tissues? (A) A (B) B (C) C (D) D A newly discovered drug is found to increase the volume of urine production. When ADH is administered, the volume of urine returns to normal. Which best describes the action of the new drug? (A) blocks the release of ADH from the kidney (B) blocks the release of ADH from the pituitary (C) triggers the release of ADH from the kidney (D) triggers the release of ADH from the pituitary Identify and describe the structure and function of important biochemical compounds, including nonsteroid and steroid hormones Why do protein hormones need to trigger a second messenger to activate a target cell? (A) They are not water soluble. (B) They bind to multiple types of cells. (C) They cannot cross cell membranes. (D) They require activation by ATP. – identify the following hormones, their source gland, and explain their general effect on the human organism: (i) melatonin (ii) thyroxine (iii) adrenaline (iv) somatotropin (HGH– human growth hormone) (v) insulin (vi) glucagon What is most likely present in high amounts in an individual who has been fasting for 24 hours? (A) glucagon (B) glucose (C) insulin (D) oxytocin The graph below shows the blood glucose levels of a healthy person over a short period of time. Which hormone is most likely secreted by the pancreas at point Y? (A) glucagon (B) insulin (C) melatonin (D) somatotropin Which term best describes the actions of adrenaline and noradrenaline? (A) antagonistic (B) complementary (C) negative feedback (D) positive feedback Analyze homeostatic phenomena to identify the feedback mechanisms involved – describe representative positive and negative feedback loops. Include: (i) hypothalamus-pituitary complex as a negative feedback control (ii) oxytocin as positive feedback control Which is responsible for maintaining a relatively constant body temperature? (A) antagonistic hormones (B) negative feedback system (C) pituitary hormones (D) positive feedback system Describe disorders and treatments linked to the secretions of the endocrine system and their effect on the homeostasis of the system and the organism as a whole. Include: (i) dwarfism (ii) giantism (iii) hyperthyroidism (iv) hypothyroidism (v) diabetes mellitus Which disorder is caused by an over-secretion of the human growth hormone (HGH)? (A) diabetes mellitus (B) dwarfism (C) giantism (D) hyperthyroidism Which is a result of hyperthyroidism? (A) decreased blood vessel diameter (B) decreased mental capacity (C) increased bone calcium (D) increased metabolic rate Dwarfism is caused by the under-secretion of which hormone? (A) adrenaline (B) HGH (C) LH (D) thyroxine What causes giantism? (A) overproduction of human growth hormone (B) overproduction of insulin (C) underproduction of human growth hormone (D) underproduction of insulin What would be the best treatment for an individual with an intolerance to cold, decreased heart rate, and weight gain, despite a decreased appetite? (A) combination of insulin, exercise, and diet to control insulin levels (B) diet to reduce the amount of dietary iodine, increasing thyroxine production (C) increase the amount of vitamin D to increase levels of blood calcium (D) injections of thyroid hormone to increase metabolic activity Which gland functions improperly when there is a lack of iodine in the diet? (A) adrenal (B) salivary (C) tear (D) thyroid Analyze examples of Canadian contributions to science and technology – investigate the role played by Frederick Banting and Charles Best in the discovery of insulin Describe the regulation of blood sugar by controlled release of insulin and glucagon perform an experiment to investigate and collect data on the endocrine system and identify specific variables involved Distinguish between questions that can be answered by science and those that cannot, and between problems that can be solved by technology and those that cannot Debate the merits of developing and using life support technology, identifying questions that are scientific, technological and social in nature