Download Research Academic Nil-Appointments

Page 1 of 35
Table of Contents
Introduction ................................................................................................................................................................. 3 Message from the Chair ............................................................................................................................................ 3 Organizational Chart ................................................................................................................................................. 4 Committees ............................................................................................................................................................... 5 Academic & Administrative Staff.............................................................................................................................. 6 Research Academic Staff, Interests, and 2008 Publications ..................................................................................... 6 Research Academic Nil-Appointments .................................................................................................................. 14 Research Academic Adjunct Appointments ........................................................................................................... 14 Clinical Academic Staff, Interests, and Publications .............................................................................................. 14 Professors Emeriti................................................................................................................................................... 19 Administrative Staff & Responsibilities ................................................................................................................. 19 Academic Awards and Honours ............................................................................................................................. 20 Undergraduate students, Graduate Students, and Trainees ................................................................................. 20 Report from the BMG Students Association President .......................................................................................... 20 Undergraduate Honour’s Project Students ............................................................................................................. 22 Graduate Students ................................................................................................................................................... 22 Graduates ................................................................................................................................................................ 22 Trainees .................................................................................................................................................................. 24 Student Awards and Honours ................................................................................................................................. 24 Seminar Series ........................................................................................................................................................... 26 Invited Speakers ..................................................................................................................................................... 26 BMG Seminar Series .............................................................................................................................................. 26 Courses ....................................................................................................................................................................... 28 Undergraduate ........................................................................................................................................................ 28 Graduate.................................................................................................................................................................. 28 Workshops .............................................................................................................................................................. 29 Medical Teaching 2008 2009 .................................................................................................................................... 30 Review of Operations ................................................................................................................................................ 33 Operating Budget .................................................................................................................................................... 33 Research Funding ................................................................................................................................................... 33 Grant Support by Faculty Member, and Source ..................................................................................................... 34 Page 2 of 35
Introduction
Message from the Chair
*********************
Welcome to the second Annual Report of the Department of Biochemistry and
Medical Genetics (BMG). I will summarize a few highlights of 2008 and
encourage you to review the report at your leisure for further details.
Dr. Geoff Hicks was named Director of the Regenerative Medicine Program
and the first recruit was appointed to our Department. Welcome Dr. Mojgan
Rastegar, we wish you much success and look forward to working with you in
the coming years. The search for additional members has been very active so
stay tuned for additional announcements in 2009!
Drs. Spencer Gibson and Jeffrey Wigle were awarded Manitoba Health
Research Council (MHRC) Chairs. Congratulations to you both, the awards
were well deserved! Our ability to capture 2 of the 3 Chairs in this first MHRC
competition to acknowledge, support and retain Manitoba’s best health
researchers is an excellent reflection of our Department.
Dr. Louise R. Simard
Professor and Head
Congratulations Dr. Francis Amara for obtaining Tenure!
The hard work of our Faculty brought in over four million research dollars. Dissemination of our basic and
clinical research resulted in 58 publication, up from last year.
Dr. Albert Chudley received the Manitoba Service Excellence Award and the Founders Award for the
Canadian College of Medical Geneticists. Dr. Cheryl Greenberg received the Scholastic Award from the
Manitoba Medical Association and the Michael Wright Award for Community Leadership. Dr. Louise Simard
received the Dr. David Green Award from Muscular Dystrophy Canada. Dr. Emöke Szathmáry obtained two
honorary Doctor of Law degrees from York (February 2008) and McMaster (June 2008) Universities. Join me
in applauding these distinctions!
It goes without saying that the successes of our Faculty members depend upon the excellence of our graduate
students. We awarded four Doctoral (Shahrzad Jalalai, Dianna Martin, Francisco Mendoza and Anton
Uvarov) and 6 Master’s (Yi Heng (Henry), Shauna Loewen, Iran Rashedi, Anoushe Sekhavat, Yongyao Tan
and Duy Truong) degrees in 2008. Dr. Dianna Martin received the 2008 Research Day E.L. Drewry Memorial
Award. Francisco Mendoza received the Merck Frosst Canada Inc. Award in Cell Biology.
A significant proportion of our students successfully competed for local, provincial and national studentships
as well as having received other important honours. Congratulations to Diana Joy Armistead, Evan Booy and
Paula Espino for their success in the CIHR Studentship competition and to Bojan Drobic for his NCIC award!
Megan Webb Azad received the CIHR National Poster Competition Silver Award as well as the Manitoba
Medical Services Foundation award. Sumit Sandhu received the Dean of Medicine Poster Award and George
Skliris was given the MHRC Post Doctorate Fellow Award; both of these awards were Manitoba
Competitions.
In closing, we have much to be proud of and it is hoped that our Department will continue to demonstrate
excellence in research, teaching, administration and outreach endeavours. Your hard work has not gone
unnoticed and your achievements have been posted on our web site in a timely manner. I look forward to
2009’s endeavours!
Page 3 of 35
Organizational Chart
Dr. L. Simard
Professor and Head
Academic
Research Academic Staff
_____________________________________________________
Amara, F.
Gietz, R.D.
Pind, S.
Arthur, G.
Graham, M.
Rampitsch, C.
Bhullar, R.
Hatch, G.
Simard, L.
Blanchaer, M.
Hicks, G.
Rastegar, M.
Choy, P.C.
Jacobs, H. K.
Stevens, F.C
Civetta, A.
Kashour, T.S.
Szathmáry, E.
Craig, D.
Kupriyanov. V.
Triggs-Raine, B.
Dakshinamurti, K. Leygue, E.
Valdimarsson, G.
Davie, J.
MacRae, A.
Vanderwel, D.
Ding, H.
Mai, S.
Wigle, J.
Eisenstat, D.
Marshall, A.
Wilkins, J
Evans, J.
Merz, D.
Wrogemann, K.
Franck, J
Mesaeli, N.
Yamada, E.
Frost, E.
Mowat, M.
Ye, J.
Gibson, S
Murphy, L.C.
Zelinski, T.
Clinical Academic
Staff
___________________
Chin, S.
Chodirker, B.
Chudley, A.
Dalton, J.
Dawson, A.
Dembinski, T.
Elliott, A.
Greenberg, C.R.
Leroux, M.
Marles, S.
Mhanni, A.
Parry, D.
Reed, M.
Spriggs, B.
Thorlacius, L.
Williams, G.
Support Staff
___________________
Burtniak, N.
Cameron, L.
Dyck, G.
Middleton, J.
Sarkar, T.
Page 4 of 35
Committees
Appointment, Promotions and
Tenure Committee
________________________
Dr. B. Triggs-Raine, Chair
Dr. G. Arthur
Dr. L. Murphy
Dr. K. Wrogemann
Ms. T. Burton, student Rep.
Alternates: Dr. J. Evans,
Dr. E. Leygue
Post Doctoral
Representative
Faculty
Graduate Student Affairs
Committee
_______________________
Dr. D. Gietz, Chair
Dr. S. Pind, Chair in training
Dr. M. Mowat
Dr. G. Arthur
Dr. R. Bhullar
Special Academics
Post Doctoral Fellows
Residents
COUNCIL
Graduate Student Admissions
Committee
________________________
Dr. L. Murphy, Chair
Dr. D. Merz, Chair in training
Dr. S. Gibson
Dr. D. Gietz
Grad Student Representative
_________________________
Evan Booy, President
Bojan Drobic, Vice President
Nil
Appointments
Graduate Student Awards
Committee
_________________________
Dr. E. Leygue, Chair
Dr. H. Ding
Dr. L. Simard
Dr. D. Merz
Ms. N. Burtniak, finance
Ms. T. Burton / Mr. E. Booy,
student Representative
Graduate Students
Page 5 of 35
Academic & Administrative Staff
Research Academic Staff, Interests, and 2008 Publications
Research Interests: Beta Catenin and LEF/TCF signalling in
Neurodegeneration of Alzheimer's Disease.
Publications:
• Salins P, He Y, Olson K, Glazner G, Kashour T, Amara F., TGF-beta1 is
increased in a transgenic mouse model of familial Alzheimer's disease and
causes neuronal apoptosis. Neurosci Lett. 2008 Jan 3;430(1):81-6. Epub
2007 Oct 30. PMID: 18063474.
Francis Amara
Associate Professor
[email protected]
Research Interests: Mechanism of action and development of lipid-based
anticancer compounds: Isolation and mechanism of action of bioactive
compounds from tropical medicinal plants.
Gilbert Arthur
Professor
[email protected]
Research Interests: Lipids and lipoproteins in health and disease.
Patrick Choy
Professor
[email protected]
Publications:
• Lin J, Lin S, Choy PC, Shen X, Deng C, Kuang S, Wu J, Xu W.The
regulation of the cardiac potassium channel (HERG) by caveolin-1., Biochem
Cell Biol. 2008 Oct; 86(5):405-15., PMID: 18923542
• Lin J, Lin S, Yu X, Choy PC, Shen X, Deng C, Kuang S, Wu J., The four
and a half LIM domain protein 2 interacts with and regulates the HERG
channel., FEBS J. 2008 Sep;275(18):4531-9. Epub 2008 Aug 1., PMID:
18680509
• Ng WW, Keung W, Xu YC, Ng KF, Leung GP, Vanhoutte PM, Choy PC,
Man RY., Genistein potentiates protein kinase A activity in porcine coronary
artery., Mol Cell Biochem. 2008 Apr;311(1-2):37-44. Epub 2007 Dec 30.,
PMID: 18165926
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Research Interests: Epigenetic regulation of gene expression in normal and
cancer cells, nuclear matrix structure and function, signal transduction
pathways, chromatin structure and function, and biomarkers in the early
detection of cancer.
Jim Davie
Professor, CRC Chair
[email protected]
Publications:
• Stein GS, Davie JR, Knowlton JR, Zaidi SK., Nuclear microenvironments
and cancer, J Cell Biochem. 2008 Aug 15;104(6):1949-52., PMID:
18649350.
• Li L, Davie JR., Association of Sp3 and estrogen receptor alpha with the
transcriptionally active trefoil factor 1 promoter in MCF-7 breast cancer
cells., J Cell Biochem. 2008 Oct 1;105(2):365-9., PMID: 18543253
• Delcuve GP, He S, Davie JR., Mitotic partitioning of transcription factors.,
J Cell Biochem. 2008 Sep 1;105(1):1-8., PMID: 18459122
• Davie JR, He S, Li L, Sekhavat A, Espino P, Drobic B, Dunn KL, Sun JM,
Chen HY, Yu J, Pritchard S, Wang X., Nuclear organization and chromatin
dynamics--Sp1, Sp3 and histone deacetylases., Adv Enzyme Regul.
2008;48:189-208. Epub 2008 Mar 14. Review., PMID: 18187045
• Kien CL, Peltier CP, Mandal S, Davie JR, Blauwiekel R., Effects of the in
vivo supply of butyrate on histone acetylation of cecum in piglets., J
Parenter Enteral Nutr. 2008 Jan-Feb;32(1):51-6., PMID: 18165447
• He S, Dunn KL, Espino PS, Drobic B, Li L, Yu J, Sun JM, Chen HY,
Pritchard S, Davie JR., Chromatin organization and nuclear
microenvironments in cancer cells., J Cell Biochem. 2008 Aug
15;104(6):2004-15., PMID: 17668423.
Research Interests: Apply mouse embryonic stem (ES) cells mediated
transgenesis to analyze a gene’s function and to create human disease models.
We are focusing on several genes that have been implicated in cell proliferation,
angiogenesis and tumorigenesis.
Hao Ding
Assistant Professor, CRC Chair
[email protected]
Publications:
• Jadin L, Wu X, Ding H, Frost GI, Onclinx C, Triggs-Raine B, Flamion B.,
Skeletal and hematological anomalies in HYAL2-deficient mice: a second
type of mucopolysaccharidosis IX, FASEB J. 2008 Dec;22(12):4316-26.
Epub 2008 Sep 4., PMID: 18772348
• Motegi, A., Liaw, H.J., Lee, K.Y., Roest, H.P., Maas, A., Wu, X., Moinova,
H., Markowitz, S.D., Ding, H., Hoeijmakers, J.H.J., Myung, K. Lysine 63linked polyubiquitination of proliferating cell nuclear antigen by HLTF and
SHPRH prevents genomic instability from stalled replication forks. Proc.
Natl. Acad. Sci. U.S.A., 2008, 105(34):12411-6
• Li, Y., Zhnag, F., Nagai, N., Tan, Z., Zhnag, S., Scotney, P., Lennartsson, J.,
Zhu, C., Qu, Y., Fang C., Hua, J., Matsuo, O., Fong, G., Ding, H., et al.
VEGF-B is an apoptosis inhibitor by suppression of BH3-only protein gene
expression via VEGFR-1. The Journal of Clinical Investigation, 2008,
118(3):913-23
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Research Interests: Epidemiology of congenital malformations, numerical
classification of phenotypic variability, prenatal screening and identification of
high risk populations
Jane Evans
Professor
[email protected]
Publications:
• Evans JA. Pre-conceptional vitamin/folic acid supplementation 2007. J
Obstet Gynaecol Can. 2008 Aug;30(8):656-7.
• De Wals P, Tairou F, Van Allen MI, Lowry RB, Evans JA, Van den Hof
MC, Crowley M, Uh SH, Zimmer P, Sibbald B, Fernandez B, Lee NS,
Niyonsenga T. Spina bifida before and after folic acid fortification in Canada.,
Birth Defects Res A Clin Mol Teratol. 2008 Sep;82(9):622-6.
• Lindsay J, Evans JA. Rate of periconceptional folic acid supplementation.
Public Health Agency of Canada Canadian Perinatal Health Report 2008
Edition, Ottawa, 2008 pp 54-56.
• León JA, Evans JA, Royale C. Prevalence of congenital anomalies. Public
Health Agency of Canada Canadian Perinatal Health Report 2008 Edition,
Ottawa, 2008 pp 158-165.
• Elliott AM, Evans JA., The association of split hand foot malformation
(SHFM) and congenital heart defects., Birth Defects Res A Clin Mol Teratol.
2008 Jun;82(6):425-34.
Research Interests: Understanding the regulation of signal transduction
pathways leading to either cell survival or cell death in cancer cells. This
research will be translated into the clinical setting for the effective treatment of
cancer.
Spencer Gibson
Associate Professor, MHRC Chair
[email protected]
Publications:
• Amrein L, Hernandez TA, Ferrario C, Johnston J, Gibson SB, Panasci L,
Aloyz R., Dasatinib sensitizes primary chronic lymphocytic leukaemia
lymphocytes to chlorambucil and fludarabine in vitro., Br J Haematol. 2008
Dec;143(5):698-706., PMID: 19062342
• Azad MB, Chen Y, Gibson SB., Regulation of autophagy by reactive
oxygen species (ROS): implications for cancer progression and treatment.,
Antioxid Redox Signal. 2008 Oct 1. [Epub ahead of print], PMID: 18828708
• Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak
TJ, Gibson SB, Booy EP, Naderi-Manesh H, Los M., Brevinin-2R(1) semiselectively kills cancer cells by a distinct mechanism, which involves the
lysosomal-mitochondrial death pathway., J Cell Mol Med. 2008
Jun;12(3):1005-22., PMID: 18494941
• Mendoza FJ, Ishdorj G, Hu X, Gibson SB., Death receptor-4 (DR4)
expression is regulated by transcription factor NF-kappaB in response to
etoposide treatment., Apoptosis. 2008 Jun;13(6):756-70., PMID: 18421578
• Ishdorj G, Graham BA, Hu X, Chen J, Johnston JB, Fang X, Gibson SB.,
Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC)
inhibitor-induced apoptosis through activation of HDAC., J Biol Chem. 2008
Jun 13;283(24):16818-29. Epub 2008 Apr 11., PMID: 18408217
• Hu X, Mendoza FJ, Sun J, Banerji V, Johnston JB, Gibson SB.,
Lysophosphatidic acid (LPA) induces the expression of VEGF leading to
protection against apoptosis in B-cell derived malignancies., Cell Signal. 2008
Jun;20(6):1198-208. Epub 2008 Feb 19., PMID: 18396013
• Henson ES, Johnston JB, Gibson SB., The role of TRAIL death receptors
in the treatment of hematological malignancies., Leuk Lymphoma. 2008
Page 8 of 35
Jan;49(1):27-35. Review., PMID: 18203008
• Chen Y, Gibson SB., Is mitochondrial generation of reactive oxygen
species a trigger for autophagy?, Autophagy. 2008 Feb 16;4(2):246-8. Epub
2007 Dec 14. Review., PMID: 18094624
• Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ,
Gibson SB., Hypoxia induces autophagic cell death in apoptosis-competent
cells through a mechanism involving BNIP3., Autophagy. 2008 Feb
16;4(2):195-204. Epub 2007 Nov 8., PMID: 18059169
Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB., Oxidative stress
induces autophagic cell death independent of apoptosis in transformed and
cancer cells., Cell Death Differ. 2008 Jan;15(1):171-82. Epub 2007 Oct 5.,
PMID: 17917680
Research Interests: Molecular genetics; Mechanisms of DNA repair in
eukaryotes. Applications of the Yeast two hybrid system. Mechanisms of DNA
transformation in yeast. The Gietz lab has its own home page describing the
best techniques of transformation in yeast.
R. Dan Gietz
Associate Professor
[email protected]
Research Interests: Functional Analysis of the genetic determinants of cancer
and human disease. The role of TLS and EWS ribonuclear proteins in DNA
repair and micro-RNA processing. Mouse modeling of human disease through
transgenic technologies.
Geoff Hicks
Associate Professor, CRC Chair
[email protected]
Publications:
•
Xie Y, Yang H, Miller JH, Shih DM, Hicks GG, Xie J, Shiu RP., Cells
deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to
oxidants with increased G2/M arrest and multinucleation., Carcinogenesis. 2008
Apr;29(4):722-8. Epub 2008 Feb 6. Erratum in: Carcinogenesis. 2008
Dec;29(12):2432., PMID: 18258604
Page 9 of 35
Research Interests: Differential gene expression during breast tumorigenesis
and breast tumor progression. Actual focus: Steroid Receptor RNA Activator
(SRA) bi-faceted gene products.
Etienne Leygue
Associate Professor
[email protected]
Publications:
• Skliris GP, Hubé F, Gheorghiu I, Mutawe MM, Penner C, Watson PH,
Murphy LC, Leygue E, Myal Y., Expression of small breast epithelial mucin
(SBEM) protein in tissue microarrays (TMAs) of primary invasive breast
cancers., Histopathology. 2008 Feb;52(3):355-69., PMID: 18269587
• Skliris GP, Leygue E, Watson PH, Murphy LC., Estrogen receptor alpha
negative breast cancer patients: estrogen receptor beta as a therapeutic target., J
Steroid Biochem Mol Biol. 2008 Mar;109(1-2):1-10. Epub 2007 Dec 8.
Review., PMID: 18243688
Research Interests: Cell migrations and axon guidance, using the model
organism C. elegans. Emphasis on forward genetics and molecular biology to
study the regulation and guidance of cell migrations and to identify novel genes
and interactions between signalling pathways in development
David Merz
Assistant Professor
[email protected]
Research Interests: Understanding the molecular mechanism of regulation of
vascular development and remodeling by calreticulin.
Nasrin Mesaeli
Associate Professor
[email protected]
Publications:
• Jalali S, Aghasi M, Yeganeh B, Mesaeli N., Calreticulin regulates insulin
receptor expression and its downstream PI3 Kinase/Akt signalling pathway.,
Biochim Biophys Acta. 2008 Dec;1783(12):2344-51. Epub 2008 Sep 17.,
PMID: 18840478.
• Uvarov AV, Mesaeli N., Enhanced ubiquitin-proteasome activity in
calreticulin deficient cells: a compensatory mechanism for cell survival.,
Biochim Biophys Acta. 2008 Jun;1783(6):1237-47. Epub 2008 Mar 20., PMID:
18405668.
Page 10 of 35
Research Interests: Identification of recessive apoptosis genes using a
promoter trap retrovirus. Mouse models of cancer, in particular the Deleted in
Liver Cancer (Dlc) family members.
Mike Mowat
Professor
[email protected]
Publications:
•
Gonçalves Dos Santos Silva A, Sarkar R, Harizanova J, Guffei A, Mowat
M, Garini Y, Mai S., Centromeres in cell division, evolution, nuclear
organization and disease., J Cell Biochem. 2008 Aug 15;104(6):2040-58.
Review., PMID: 18425771
•
Hatch GM, Gu Y, Xu FY, Cizeau J, Neumann S, Park JS, Loewen S,
Mowat MR., StARD13(Dlc-2) RhoGap mediates ceramide activation of
phosphatidylglycerolphosphate synthase and drug response in Chinese hamster
ovary cells., Mol Biol Cell. 2008 Mar;19(3):1083-92. Epub 2007 Dec 27.,
PMID: 18162584
•
Hatch GM, Gu Y, Xu FY, Cizeau J, Neumann S, Park J-S, Loewen S and
Mowat MR., RhoGAP mediates ceramide activation of
phosphatidylglycerolphosphate synthase and drug response in Chinese hamster
ovary cells. FASEB J. 2008 Apr 01;22(2_MeetingAbstracts):269Research Interests: Mechanism of action of hormones and growth factors in
human breast cancer. Estrogen signalling mechanisms in human breast cancer,
tumorbanking, molecular pathology
Leigh Murphy
Professor
[email protected]
Publications:
•
Skliris GP, Rowan BG, Al-Dhaheri M, Williams C, Troup S, Begic S,
Parisien M, Watson PH, Murphy LC., Ch Immunohistochemical validation of
multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in
tissue microarrays of ERalpha positive human breast carcinomas., Breast
Cancer Res Treat. 2008 Dec 23. [Epub ahead of print], PMID: 19104930
•
Barnes RO, Parisien M, Murphy LC, Watson PH., Influence of evolution
in tumor biobanking on the interpretation of translational research., Cancer
Epidemiol Biomarkers Prev. 2008 Dec;17(12):3344-50., PMID: 19064549
•
Weitsman GE, Weebadda W, Ung K, Murphy LC., Reactive oxygen
species induce phosphorylation of serine 118 and 167 on estrogen receptor
alpha., Breast Cancer Res Treat. 2008 Oct 21. [Epub ahead of print], PMID:
18941890
•
Flynn JM, Dimitrijevich SD, Younes M, Skliris G, Murphy LC,
Cammarata PR., Role of wild-type estrogen receptor-beta in mitochondrial
cytoprotection of cultured normal male and female human lens epithelial cells.,
Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E637-47. Epub 2008 Jun 24.,
PMID: 18577698
•
Skliris GP, Hubé F, Gheorghiu I, Mutawe MM, Penner C, Watson PH,
Murphy LC, Leygue E, Myal Y., Expression of small breast epithelial mucin
(SBEM) protein in tissue microarrays (TMAs) of primary invasive breast
cancers., Histopathology. 2008 Feb;52(3):355-69., PMID: 18269587
•
Skliris GP, Leygue E, Watson PH, Murphy LC., Estrogen receptor alpha
negative breast cancer patients: estrogen receptor beta as a therapeutic target., J
Steroid Biochem Mol Biol. 2008 Mar;109(1-2):1-10. Epub 2007 Dec 8.
Review., PMID: 18243688
Page 11 of 35
Research Interests: Identification and characterization of mutations in the
gene encoding 3-phosphoglycerate dehydrogenase; role of serine metabolism in
growth and development of the human central nervous system; protein
synthesis, folding, and targeting; expression and targeting of hyaluronidase
enzymes.
Steven Pind
Assistant Professor
[email protected]
Research Interests: Gene therapy of Neurological Disorders with an
emphasize on Rett Syndrome, HOX/HOX-Targets in Neural Stem Cell /Brain
Cancer Stem Cell fate decisions, Epigenetic control of Stem Cell neurogenesis
Mojgan Rastegar
Assistant Professor
[email protected]
Research Interests: Molecular genetics and cellular biology of the SMN
(survival motor neuron) gene implicated in spinal muscular atrophy (SMA).
Genetics of the complex trait attention deficit/hyperactivity disorder (ADHD).
Publications:
• Ouellet-Morin I, Wigg KG, Feng Y, Dionne G, Robaey P, Brendgen M,
Vitaro F, Simard L, Schachar R, Tremblay RE, Pérusse D, Boivin M, Barr CL.,
Association of the dopamine transporter gene and ADHD symptoms in a
Canadian population-based sample of same-age twins., Am J Med Genet B
Neuropsychiatr Genet. 2008 Dec 5;147B(8):1442-9., PMID: 18165969
Louise Simard
Professor and Department Head
[email protected]
Page 12 of 35
Research Interests: Lysosomal storage disorders including genetic,
biochemical and animal models aimed at determining the function of
hyaluronidases in health and disease; Identification and characterization of
disease genes in unique populations.
Barb Triggs-Raine
Professor
[email protected]
Publications:
•
Martin DC, Atmuri V, Hemming RJ, Farley J, Mort JS, Byers S,
Hombach-Klonisch S, Csoka AB, Stern R, Triggs-Raine BL., A mouse model
of human mucopolysaccharidosis IX exhibits osteoarthritis., Hum Mol Genet.
2008 Jul 1;17(13):1904-15. Epub 2008 Mar 15. Erratum in: Hum Mol Genet.
2008 Sep 15;17(18):2919. Csoka, Antonei B [added]., PMID: 18344557\
•
Hemming R, Martin DC, Slominski E, Nagy JI, Halayko AJ, Pind S,
Triggs-Raine B., Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose
overexpression increases hyaluronidase 1 activity in cultured cells.,
Glycobiology. 2008 Apr;18(4):280-9. Epub 2008 Jan 30.,PMID: 18234732
•
Atmuri V, Martin DC, Hemming R, Gutsol A, Byers S, Sahebjam S,
Thliveris JA, Mort JS, Carmona E, Anderson JE, Dakshinamurti S, TriggsRaine B., Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of
hyaluronan accumulation., Matrix Biol. 2008 Oct;27(8):653-60. Epub 2008 Aug
14, PMID: 18762256
•
Jadin L, Wu X, Ding H, Frost GI, Onclinx C, Triggs-Raine B, Flamion B.,
Skeletal and hematological anomalies in HYAL2-deficient mice: a second type
of mucopolysaccharidosis IX?, FASEB J. 2008 Dec;22(12):4316-26. Epub 2008
Sep 4.,PMID: 18772348
Research Interests: The control of lymphatic and blood vessel growth by the
homeobox transcription factors Prox1 and Meox2.
Publications:
•
Wigle J.T. and Eisenstat D.D. Homeobox genes in vertebrate forebrain
development and disease. Clin Genet 73:212-26 2008.
•
de Melo, J., Zhou, Q.P.; Zhang, Qi; Zhang, Zhang, S.; Fonseca, M.;
Wigle, J.T. and Eisenstat, D.D. Dlx2 Homeobox Gene Transcriptional
Regulation of Trkb Neurotrophin Receptor Expression during Mouse Retinal
Development Nucleic Acids Research 36:872-84, 2008
Jeff Wigle
Associate Professor, MHRC Chair
[email protected]
Research Interests: Molecular basis of genetic diseases, with special emphasis
on muscular dystrophies and genetic diseases in special populations. The
current focus is on limb girdle muscular dystrophies.
Klaus Wrogemann
Professor & Associate Head
[email protected]
Page 13 of 35
Research Academic Nil-Appointments
Bhullar, R.
Chin, S.
Chodirker, B.
Chudley, A.
Dalton, J.
Dawson, A.
Dembinski, T.
Eisenstat, D.
Elliott, A.
Graham, M.
Greenberg, C.R.
Hatch, G.
Jacobs, H. K.
Leroux, M.
MacRae, A.
Mai, S.
Marles, S.
Marshall, A.
Mhanni, A.
Parry, D.
Reed, M.
Spriggs, B.
Szathmáry, E.
Thorlacius, L.
Valdimarsson, G.
Wilkins, J.
Williams, G.
Research Academic Adjunct Appointments
Civetta, A.
Craig, D.
Franck, J
Frost, E.
Graham, M.
Kupriyanov. V.
Rampitsch, C.
Vanderwel, D.
Ye, J.
Clinical Academic Staff, Interests, and Publications
Research Interests: Clinical genetics, genetic epidemiology, prenatal
diagnosis
B.N. Chodirker
Professor, MD, FRCPC, FCCMG
[email protected]
Publications:
• Charames GS, Ramyar L, Mitri A, Berk T, Cheng H, Jung J, Bocangel P,
Chodirker B, Greenberg C, Spriggs E, Bapat B., A large novel deletion in the
APC promoter region causes gene silencing and leads to classical familial
adenomatous polyposis in a Manitoba Mennonite kindred., Hum Genet. 2008
Dec;124(5):535-41. Epub 2008 Nov 4., PMID: 18982352
• Rusnak AJ, Hadfield MI, Chudley AE, Marles SL, Reid GJ, Chodirker
BN., Increased nuchal translucency thickness: a potential indicator for
Ritscher-Schinzel syndrome., Fetal Diagn Ther. 2008;24(4):395-9. Epub 2008
Oct 28., PMID: 18957854
• Chodirker BN, Chudley AE., Routine genetic testing for Asperger
syndrome., Genet Med. 2008 Nov;10(11):843-5; author reply 845. No abstract
available., PMID: 18941416
Boycott KM, Parboosingh JS, Chodirker BN, Lowry RB, McLeod DR,
Morris J, Greenberg CR, Chudley AE, Bernier FP, Midgley J, Møller LB,
Innes AM., Clinical genetics and the Hutterite population: a review of
Mendelian disorders., Am J Med Genet A. 2008 Apr 15;146A(8):1088-98.
Review., PMID: 18348266
Page 14 of 35
Research Interests: Clinical genetics, dysmorphology, clinical teratogenesis,
Fetal Alcohol Syndrome, clinical cytogenetics and genetics of mental
retardation, X-linked mental retardation, autism spectrum disorders
A.E. Chudley
Professor, MD, FRCPC, FCCMG
[email protected]
Publications:
• Metcalfe KA, Birenbaum-Carmeli D, Lubinski J, Gronwald J, Lynch H,
Moller P, Ghadirian P, Foulkes WD, Klijn J, Friedman E, Kim-Sing C,
Ainsworth P, Rosen B, Domchek S, Wagner T, Tung N, Manoukian S, Couch
F, Sun P, Narod SA; and the Hereditary Breast Cancer Clinical Study
GroupOther Members of the Hereditary Breast Cancer Clinical Study Group
(including Chudley, AE.). International variation in rates of uptake of
preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer.
2008 Jan 14; [Epub ahead of print].
• Orton NC, Innes AM, Chudley AE, Bech-Hansen NT. Unique Disease
Heritage of the Dutch-German Mennonite Population. Am J Med Genet
146A:1072-1087, 2008.
• Boycott KM, Parboosingh JS, Chodirker BN, Lowry RB, McLeod DR,
Morris J, Greenberg CR, Chudley AE, Bernier FP, Midgley J, Møller LB,
Innes AM Clinical Genetics and the Hutterite population: A review of
Mendelian disorders. Am J Med Genet 146A:1088-1098, 2008.
• Hammond P, Forster-Gibson C, Chudley AE, Allanson JE, Hutton TJ,
Holden JJA, Lewis MES. Face-Brain Asymmetry in Autism Spectrum
Disorders. Molecular Psychiatry 13:614-623, 2008.
• Chudley AE. Perspective. Fetal Alcohol Spectrum Disorder. Mission
Impossible-Counting the Invisible? Arch Dis Child 93:721-722, 2008.
• Metcalfe KA, Ghadirian P, Foulkes W Kim-Sing C, Ainsworth P, Rosen
B, Armel S, Poll A, Eisen A, Gilchrist D, Chudley AE, Maugard C, Lemire
EG, Sun P, & Narod SA. Family History as a Predictor of Uptake of Cancer
Preventive Procedures by Women with a BRCA1 or BRCA2 Mutation. Clin
Genet. 73:474-9. 2008.
• Kotsopoulos J, Librach CL, Lubinski J, Gronwald J, Kim-Sing C,
Ghadirian P, Lynch HT, Moller P, Foulkes WD, Randall S, Manoukian S,
Pasini B, Tung N, Ainsworth PJ, Cummings S, Sun P, Narod SA; Hereditary
Breast Cancer Clinical Study Group (including Chudley, AE). Infertility,
treatment of infertility, and the risk of breast cancer among women with
BRCA1 and BRCA2 mutations: a case-control study. Cancer Causes Control.
19:1111-9. 2008 Epub 2008 May 29.
• Rusnak A, Marles, S, Chudley AE, Reid G, Chodirker B. Increased
nuchal translucency thickness; A potential indicator for Ritscher-Schinzel
syndrome. Fetal Diagnosis and Therapy 24;395-399, 2008.
• Liu X, Novosedlik N, Wang A, Hudson M, Cohen I, Chudley AE,
Forster-Gibson CJ, Lewis MES, Holden JJA .The DLX1and DLX2 genes and
Susceptibility to Autism Spectrum Disorders. Eur J Hum Genet Advance
online publication 27 August 2008; doi: 10.1038/ejhg.2008.148.
• Chodirker BN, Chudley AE. Routine Genetic Testing for Asperger
Syndrome. Letter to the Editor. Genetics in Medicine 10:843-845, 2008.
• Tyson C, Qiao Y, Harvard C, Liu X, Arbour L, Bernier FP, McGillivray B,
Farell SA, Chudley AE, Clarke L, Gibson W, Dyack S, McLeod R, Costa T,
VanAllen M, Yong SL, Graham GE, MacLeod P, Patel M, Hurlburt J, Holden
JJA, Lewis MES and Rajcan-Separovic E. Submicroscopic deletions of 11q2425 in individuals without Jacobsen syndrome: re-examination of the critical
region by high-resolution array-CGH. Mol Cytogenet. 11;1(1):23, 2008 [Epub
ahead of print].
Page 15 of 35
Research Interests: Clinical genetics, inborn errors of metabolism and
application of recombinant DNA technology to the study of human genetic
disorders especially neuromuscular disorders, glutaric acidemia, and carnitine
palmitoyl transferase-1 deficiency.
Publications:
C.R. Greenberg
Professor, MD, CM, FRCPC, FCCMG
[email protected]
• Charames GS, Ramyar L, Mitri A, Berk T, Cheng H, Jung J, Bocangel P,
Chodirker B, Greenberg C, Spriggs E, Bapat B., A large novel deletion in the
APC promoter region causes gene silencing and leads to classical familial
adenomatous polyposis in a Manitoba Mennonite kindred., Hum Genet. 2008
Dec;124(5):535-41. Epub 2008 Nov 4., PMID: 18982352
• Lwiwski N, Greenberg CR, Mhanni AA., Genetic testing of children at
risk for adult onset conditions: when is testing indicated?, J Genet Couns.
2008 Dec;17(6):523-5. Epub 2008 Jul 8., PMID: 18607700
• Boycott KM, Parboosingh JS, Chodirker BN, Lowry RB, McLeod DR,
Morris J, Greenberg CR, Chudley AE, Bernier FP, Midgley J, Møller LB,
Innes AM., Clinical genetics and the Hutterite population: a review of
Mendelian disorders., Am J Med Genet A. 2008 Apr 15;146A(8):1088-98.
Review., PMID: 18348266
Research Interests: Clinical Genetics and Inborn Errors of Metabolism.
Research focus is in epigenetics and how it relates to human disorders and
DNA methylation role in early developmental processes and its relationship to
specific birth defects such as conotruncal anomalies of the heart.
A. Mhanni
Assistant Professor, MD, FRCPC,
FCCMG, FACMG, Ph.D
[email protected]
Publications:
• Tyson C, Dawson AJ, Bal S, Tomiuk M, Anderson T, Tucker D, Riordan
D, Chudoba I, Morash B, Mhanni A, Chudley AE, McGillivray B, Parslow
M, Rappold G, Roeth R, Fawcett C, Qiao Y, Harvard C, Rajcan-Separovic E.
(2009): Molecular cytogenetic investigation of two patients with Y
chromosome rearrangements and intellectual disability. Am J Med Genet.
149A(3):490-5.
• C. N. Joshi, C. R. Greenberg, A. A. Mhanni, M. S. Salman (2008): The
Ketogenic diet in Alpers Huttenlocher syndrome. Manuscript accepted for
publication in Pediatric Neurology (October, 08)
• N. Lwiwski, C.R. Greenberg and A. A. Mhanni (2008): Genetic Testing
of Children at Risk for Adult Onset Conditions: when is testing indicated? J
Genet Couns. 17(6):523-5 Epub 2008 Jul 8., PMID: 18607700.
• Mhanni A et al., (2008): hyperornithinaemia, hyperammonaemia,
homocitrullinuria (HHH) syndrome presenting with acute fulminant hepatic
failure. Manuscript accepted for publication The Pediatric Journal of
Gastroenterology and Nutrition.46(3):312-5.
Page 16 of 35
2008 ANNUAL REPORT
WRHA Program in Genetics and Metabolism
The Program in Genetics and Metabolism is a primary Program within the Winnipeg Regional Health Authority
(WRHA). This status was achieved in September 2004. The Genetics and Metabolism University affiliations include
the Departments of Pediatrics and Child Health, and Biochemistry and Medical Genetics.
The Genetics and Metabolism mandate of the program is the provision of exemplary clinical service to all patients and
Programs of the WRHA. In the discharge of this mandate, the Program endeavours to establish a responsive system
of service delivery. In 2008, approximately 5,500 patients were seen through the service.
What is new in 2008:
• New clinic and office space has been identified and we plan to move into the additional space in the Spring
2009.
• Nikki Lwiwski, one of the genetic counselling assistants left to take further education. We welcome Lisa
Levesque to our Program
• As a WRHA Program, we report to senior management. Our VP was Mr. Mark Nescar, who left the WRHA
to work for a private company. We thank Mark for his short but effective time with us. We welcomed Mr.
Milton Sussman as our WRHA Team leader.
• Our senior resident Julie Richer successfully completed her training and is now an Assistant Professor at the
University of Ottawa at CHEO.
Human Resources
The Genetics and Metabolism Program is currently provided by medical staff, genetic counsellors, genetic assistants
and administrative and secretarial support staff, who are primarily located at the HSC site.
Management Team
WRHA senior representative: Mr. Milton Sussman
Medical Director: Dr. Albert Chudley
Administrative Director: Mr. Ron VanDenakker
Program Director: Dr Alison Elliott, PhD
Medical Staff/Faculty:
Bernie N. Chodirker, MD
Albert E. Chudley, MD
Cheryl R. Greenberg, MD
Sandra Marles, MD
Aziz Mhanni, MD., PhD
Cross-Appointed Members:
Angie Dawson, PhD
Jane Evans, PhD
Louise Simard, PhD
Beth Spriggs, PhD
Barbara Triggs-Raine, PhD
Klaus Wrogemann, PhD
Emeritus Member:
James C. Haworth, MD
Page 17 of 35
Genetic Counsellors:
Patricia Bocangel
Linda Carter
Karen MacDonald
Judy Saltel-Olson (on leave from June 2008)
Shannon Sanders
Kim Serfas
Genetic Counselling Assistants:
Tatum Anderson
Scarlett Drescher
Nikki Lwiwski (To July 2008)
Lisa Levesque (from September 2008)
Quinn Porter (from Sept 2008)
Medical Genetics Residents:
Mariya Kozenko, MD
Julie Richer, MD
Alison Rusnak, MD
Jagdeep Walia, MBBS
PGY5
PGY5
PGY5+
PGY2
(graduated July 2008)
Page 18 of 35
Professors Emeriti
M.C. Blanchaer
K. Dakshinamurti
F.C. Stevens
E.W. Yamada
Administrative Staff & Responsibilities
Front Row (left to right) Nadia Burtniak - Finance Officer; Gerhard Dyck - Office Manager
Back Row (left to right) Tuntun Sarkar - Student Liaison; Jan Middleton - Communications and Media; Lil
Cameron - Employee Records.
Page 19 of 35
Academic Awards and Honours
Honours and Awards
Dr. Francis Amara
Dr. Albert Chudley
Dr. Spencer Gibson
Dr. Cheryl
Greenberg
Dr. Geoff Hicks
Dr. Louise Simard
Dr. Emöke
Szathmáry
Dr. Jeffrey Wigle
-
approved for tenure (January 2008)
Manitoba Service Excellence Award - Partnership category (June 2008)
Founders Award for the Canadian College of Medical Geneticists (September 2008)
Manitoba Health Research Council Research Chair Award (June 2008)
Scholastic Award from the Manitoba Medical Association. (May 2008)
Michael Wright Award for Community Leadership (June 2008)
Director, Regenerative Medicine (2008)
Dr. David Green Award by Muscular Dystrophy Canada (September 2008)
honorary Doctor of Law degree from York University (February 2008)
honorary Doctor of Law degree from McMaster University (June 2008)
promoted to Associate Professor (April 2008)
Manitoba Health Research Council Research Chair Award (June 2008)
Undergraduate students, Graduate Students, and Trainees
Report from the BMG Students Association President
Annual Report of the Biochemistry & Medical Genetics Students Association
The 2007/2008 student council elections held in September 2007 resulted in the appointment of the
following individuals to the Biochemistry and Medical Genetics student council:
President: - Evan Booy
Vice-President: - Bojan Drobic
Secretary/Treasurer: - Pamela Miller
GSA Representative: - Meghan Azad
Appointment, Promotions & Tenure and Grad Students Awards Committee Rep: - Teralee Burton
Sports Representatives: - Jimin Guo and Yongyao (Yoyo) Tan
Social Representatives: - Ludivine Coudiere, Paula Espino and Francisco Mendoza
Librarian: - Ludivine Coudiere
Events: The BMG student association had a very active social program with well attended events. A year
end wind-up party was held in the spring and was a great way to finish off the academic year. Activities
began again in the fall when students from BMG and Immunology participated in a paintball outing.
Additionally, a Halloween party was held that included a costume contest, pumpkin carving, games and
food. The annual Christmas party was a great success and included gingerbread house decorating as well as
a gift exchange. In February we had an event centered around the Festival du Voyageur to give the students
a taste of the French Canadian culture in Manitoba A typical voyageur-lunch was provided which included
bannock and pea-soup and students had time to socialize. The year end wind-up party in the spring was
combined with an awards ceremony, where the best presentations of the past departmental seminar series
were awarded. In September the new academic year was started with a welcome-party which we also used
to elect the new student representatives of the department.
Page 20 of 35
Report from the GSA Rep: Meghan Azad attended all of the monthly Health Sciences Graduate Students
Association (HSGSA) meetings this year. In September the position was taken up by Cordula Buse. Both
Meghan and Cordula helped organize HSGSA social events such as the Valentine’s Wine & Cheese, Spring
it up, Pubmed Night etc. As HSGSA councillor, Meghan served on the Mentorship Award Committee and
Distinguished Lectureship committee. Finally, Meghan and Cordula prepared and submitted the two
departmental grant applications to receive the semi-annual cash disbursement from the GSA.
Report from the Treasurer: The BMG Graduate Students Association account opened with a balance of
$434.34 in January 2008. After funding various student social activities we closed with a balance of
$279.36 by December 2008. Saving policies were implemented to ensure the account will retain sufficient
funds for future activities.
Report from the Graduate Student Awards & Academic Standards Student Representative: Teralee
Burton met with this Committee to discuss student award applications to rank applications for University of
Manitoba Graduate Fellowship, Manitoba Health Research Council, and the Health Sciences studentships.
As the Academic Standards Student Representative, she met with the Academic Standards committee to
discuss applications for tenure and/or promotion and cross-appointment to the department.
Sports: This was a quiet year for our department. In the past we organized teams for a variety of sports
including floor hockey, volleyball and soccer, playing in the intramural leagues. The newly elected sports
reps are looking forward to putting some teams together in the coming winter.
Evan Booy
President
Page 21 of 35
Undergraduate Honour’s Project Students
Andrea Kroeker
Daniel Vincett
David Chudley
David Tang
Lana Rosenfield
Kalon A. De Gagné
Graduate Students
Master of Science (MSc)
Doctor of Philosophy (Ph.D.)
Diana (Joy) Armistead – Supervisor: Dr. Barb Triggs-Raine
Ludivine Coudiere – Supervisor: Dr. David Merz
Scarlett Drescher – Supervisor: Dr. Jane Evans
Mehdi Eshraghi – Supervisor: Dr. Jeff Wigle
Jimin Guo – Supervisor: Dr. Etienne Leygue
Ravikumar Jayachandran – Supervisor: Dr. Louise Simard
Dilshad Khan – Supervisor: Dr. Jim Davie
Lisa Levesque – Supervisor: Dr. Alberto Civetta
Pamela Miller – Supervisor: Dr. Hao Ding
Meenal Moudgil – Supervisor: Dr. Mike Mowat
Md Zinnatun Nabi,. – Supervisor: Dr. Hao Ding
Vanessa Pinto – Supervisor: Dr. David Eisenstat
Iran Rashedi – Supervisor: Dr. Phillip Gardiner
Sumit Sandhu – Supervisor: Dr. Hao Ding
Caroline Shields – Supervisor: Dr. Mike Mowat
Yongyao (Yoyo) Tan – Supervisor: Dr. David Eisenstat
Duy Truong – Supervisor: Dr. Dan Gietz
Yi Yan – Supervisor: Dr. Etienne Leygue
Hongmei Zeng – Supervisor: Dr. Geoff Hicks
Yueqin (Jane) Zhou – Supervisor: Dr. Geoff Hicks
Vasantha Atmuri – Supervisor: Dr. Barb Triggs-Raine
Meghan Azad – Supervisor: Dr. Spencer Gibson
Shannon Baxter - Supervisor: Dr. Jeff Wigle
Sara Beiggi – Supervisor: Dr. Spencer Gibson
Evan Booy – Supervisor: Dr. Spencer Gibson
Teralee Burton - Supervisor: Dr. Spencer Gibson
Shilpa Chooniedass - Supervisor: Dr. Etienne Leygue
Josette Douville – Supervisor: Dr. Jeff Wigle
Bojan Drobic – Supervisor: Dr. Jim Davie
Paula Espino – Supervisor: Dr. Jim Davie
Dhimankrishna Ghosh – Supervisor: Dr. John Wilkins
Shahrzad Jalali – Supervisor: Dr. Nasrin Mesaeli
Trung Le – Supervisor: Dr. David Eisenstat
Lin Li – Supervisor: Dr. Jim Davie
Jaswinder Mangat – Dr. Desiree Vanderwel
Dianna Martin – Dr. Barb Triggs-Raine
Francisco Mendoza – Supervisor: Dr. Spencer Gibson
Ellert Nichols – Supervisor: Dr. Doug Craig
Carl Olson – Supervisor: Dr. Louise Simard
Anton Uvarov – Supervisor: Dr. Nasrin Mesaeli
Yanmin Yang – Supervisor: Dr. Valery Kupriyanov
Behzad Yeganeh – Supervisor: Dr. Nasrin Mesaeli
Total – 20
Total - 22
Graduates
Yi Heng (Henry) M.Sc.
Supervisor: Dr. Klaus Wrogemann
Thesis Title: The role of TRIM32 in Limb-Girdle Muscular Dystrophy type 2H (LGMD2H)
Page 22 of 35
Shahrzad Jalalai Ph.D.
Supervisor: Dr. Nasrin Mesaeli
Thesis Title: Characterization of Signaling Pathways Involved in Cell Survival and Apoptosis in
Calreticulin Deficient Mouse Embryonic Fibroblast Cells
Shauna Loewen M.Sc.
Supervisor: Dr. Michael Mowat
Thesis Title: Dlc-1 and Dlc-2, Studies of Two RhoGAP Genes in Etoposide Resistance and
Apoptosis
Dianna Martin Ph.D.
Supervisor: Dr. Barb Triggs-Raine
Thesis itle: Characterization of a Hyaluronidase 1 (Hyal1) null mouse and the examination of
the role of Hyal1 in tissue hyaluronan turnover
Francisco Mendoza Ph.D.
Supervisor: Dr. Spencer Gibson
Thesis Title: Analysis of the role of MEKK1 as a molecular switch between cell survival and
death
Iran Rashedi M.Sc.
Supervisor: Dr.’s Marek Los/Philip Gardiner (Physiology)
Thesis Title: The Role of Dnase X In Skeletal Muscle Function Addressed By Targeted
Disruption Of The Gene In Murine Model
Anoushe Sekhavat M.Sc.
Supervisor: Dr. Jim Davie
Thesis Title: Histone deacetylase inhibitors: mode of inhibition and histone deacetylase
phosphorylation
Yongyao Tan M.Sc.
Supervisor: Dr. David Eisenstat
Thesis Title: Pax6 and Dlx2 Homeobox Genes Regulate the Extracellular Matrix molecule
Tenascin-C in Vertebrate Forebrain Development
Duy Truong M.Sc.
Supervisor: Dr. Dan Gietz
Thesis itle: A Library Screen for Yeast Mutants Defective in Transformation by the Lithium
Acetate / Single Stranded DNA / Polyethylene Glycol Method
Anton Uvarov Ph.D.
Supervisor: Dr. Nasrin Mesaeli
Thesis Title: Enhanced proteasome mediated protein degradation in calreticulin deficient cells:
A prosurvival mechanism
Page 23 of 35
Trainees
Post Doc Fellows:
Sajesh Babu – Supervisor: Dr. Hao Ding
Sudharsana Rao Ande – Supervisor: Dr. Leigh C. Murphy
Arunkumar Arumugam – Supervisor: Dr. Leigh C. Murphy
Yongqiang (Paul) Chen – Supervisor: Dr. Spencer Gibson
Sumin Lu – Supervisor: Dr. Jim Davie
Soma Mandal – Supervisor: Dr. Jim Davie
Elizabeth McLachlan – Supervisor: Dr. Leigh C. Murphy
Arzu Ozturk – Supervisor: Dr. Geoff Hicks
Beatriz Perez-Cadahia – Supervisor: Dr. Jim Davie
Mohammed G. Sabbir – Supervisor: Dr. Mike Mowat
Ashok Kumar Sekar – Supervisor: Dr. Spencer Gibson
Wineeta Weebadda – Supervisor: Dr. Leigh C. Murphy
Anne Zuse – Supervisor: Dr. Leigh C. Murphy
Medical Genetic Residents*:
* supervised by Dr. Bernie Chodirker
Mariya Kozenko, MD
Julie Richer, MD
Alison Rusnak, MD
Jagdeep Walia, MBBS
PGY5
PGY5
PGY5+
PGY2
(graduated July 2008)
Student Awards and Honours
CIHR
Diana Joy Armistead
NCIC
Bojan Drobic
MHRC
Shannon Baxter
Other
Cordula Buse (MGS)
Evan Booy
Sara Beiggi
Mehdi Eshraghi (MICH)
Paula Espino
Josette Douville
Dianna Martin (CHF)
Dilshad Khan
Zinnatun Nabi (UMGF)
Lisa Renee Levesque
Ravikumar Ramachandran (MGS)
Vanessa Pinto
Behzad Yeganeh (ICS)
Iran Rashedi
Sumit Sandhu
Caroline Shields
Yanmin Yang
Yan Yi
Hongmei Zeng
Shannon Baxter
Sara Beiggi
Page 24 of 35
Federal Agencies
‐ Canadian Institutes of Health Research (CIHR)
‐ National Cancer Institute of Canada (NCIC)
Provincial Agencies
‐ Manitoba Health Research Council (MHRC)
Other Agencies
‐ Children’s Hospital Foundation Inc. Award (CHF)
‐ Institute of Cardiovascular Sciences (ICS)
‐ Manitoba Graduate Scholarship (MGS)
‐ Manitoba Institute of Child Health (MICH)
‐ University of Manitoba Graduate Fellowships (UMGF)
Canadian Student Health Research Forum - 2008 Research Days
Dianna Martin
Meghan Webb Azad
George Skliris
Sumit Sandhu
Francisco Mendoza
‐
‐
‐
‐
‐
‐
The E. L. Drewry Memorial Award
CIHR National Poster Competition – Silver Award
Manitoba Medical Services Foundation Award
Manitoba Health Research Council Post Doctorate Fellow Award
(Manitoba Competition)
Dean of Medicine Poster Award (Manitoba Competition)
Merck Frosst Canada Inc. Award in Cell Biology
‐
Department of Biochemistry & Medical Genetics Awards:
Sumit Sandhu
Meghan Azad
Teralee Burton
‐
‐
‐
Phyllis J. McAlpine Graduate Fellowship
Human Genetics Endowment Fund Graduate Student Award
Mindel Rady Olenick Fellowship in Human Genetics
Page 25 of 35
Seminar Series
Invited Speakers
Date
Speaker
Topic
May 23, 2008
Xin-Min Li, MD, PhD, FRCPC Professor and
Ruth Hurd Research Chair, Department of
Psychiatry; and
Director, International Medical Graduate Program,
Faculty of Medicine. Shihuan Kuang, Ph.D.
Assistant Professor
Department of Animal Science
Purdue University Dr. Euridice Carmona
Assistant Professor
Department of Medicine,
University of Montreal
Maisonneuve-Rosemont Hospital Research Centre
The Departments of Anatomy and Cell Science,
Biochemistry and Medical Genetics, and
Physiology are pleased to announce the inaugural
joint seminar series.
Dr. John Giesy
Professor and Canada Research Chair in
Environmental Toxicology, Dept of Veterinary
Biomedical Sciences and Toxicology Centre,
University of Saskatchewan Visiting Speaker – External Examiner for Dhiman
Ghosh
Dr. Juergen Kast, Assistant Professor
Biomedical Research Centre
University of British Columbia
"Therapeutic Strategies for Neurodegenerative
Disorders" May 30, 2008 June 3, 2008 June 9, 2008 September 18,
2008 "Stem cell self-renewal in muscle"
"Role of somatic hyaluronidases in ovarian
function and ovarian tumor progression" "Perfluorinated Chemicals in the
Environment: The history of an
Environmental Issue" "Platelets, Drugs and Proteome"
BMG Seminar Series
Date
Speaker
Title/Topic of Presentation
Jan. 9/08
Ellert Nichols
Single Molecule Enzymology
Jan. 23/08
Dhiman Ghosh
Defining Membrane Proteins: A Proteomic and Physicochemical Approach
Jan. 30/08
Shilpa Chooniedass
Feb. 6/08
Victor Yang
The steroid receptor RNA activator protein (SRAP) acts as a transcription
repressor
Comparison of Ischemia and Cryoinjury-induced Myocardial Infarction
Feb. 13/08
Vasantha Atmuri
Characterization of Hyaluronidase 3 Knockout Mice
Feb. 20/08
Meghan Azad
Hypoxia-induced autophagy & the role of BNIP3
Feb. 27/08
Scarlett Drescher
Multiple Vertebral Segmentation Defects
Mar. 5/08
1) Ludivine Coudiere
Cell Migration Regulation by Fgf and Wnt Signaling Pathways
2) Jimin Guo
SRA mRNA Alternative Splicing
Page 26 of 35
Mar. 12/08
1) Yi Yan
The Interaction Between SRAP and Erβ
2) Hongmei Zeng
Motifs Responsible for the Relocalization of TLS
1) Lisa Levesque
Identification of Genes in Male Reproductive Pathway in Drosophla
2) Caroline Shields
The role of Dlc2 in ceramide signalling to PGP synthase
1) Mehdi Eshraghi
Role of Prox1 in Development of Lymphatic Vessels
2) Yongyao Tan
Role of Dlx2 & Pax6 in Veterbrate Forebrain Development
1) Ravi Jayachandra
2) Iran Rashedi
Functional characterization of the transcription complex regulating Smn
promoter activity in living cells
Primary characterization of mice lacking a muscle-specific DNase
1) Joy Armistead
Characterization of the Molecular Basis of Bowen Conradi Syndrome
2) Pamela Miller
Trim2 and Trim32 Yeast Two-hybrid Screening
1) Zinnatun Nabi
Identification of Rtel-interacting proteins
2) Vanessa Pinto
1) Dilshad Khan
The Role of DLX1/2 Transcription Factors on the Regulation and Expression
of CRX
The regulation of Histone deacetylases (HDACs) by phosphorylation
2) Yueqin Zhou
TLs tangents specific MRNA to Immune-Syrepse
Apr. 30/08
Carl Olson
May 7/08
Shannon Baxter
May 14/08
Josette Douville
Analysis of SMN1 Gene Expression and Function during Neuronal Cell
Differentiation
Mechanism of Prox1 Mediated Transcriptional Regulation of the Cyclin E1
Promoter
Role of Meox in Vascular Endothelial Cells
May 21/08
Sumit Sandhu
Transgenic dissection of a DNA helicase to understand its role in tumorigenesis
May 28/08
Evan Booy
LPA Mediated Pro-Survival Signaling
June 4/08
Lin Li
Oct. 1/08
Dr. Mojgan Rastegar
Sp3 is preferentially associate with TFF1 gene promoter in response to estrgen
treatment in MCF-7 cells
Neural Stem Cells, Epigenetics and Gene Therapy of Rett Syndrome
Oct. 8/08
Ellert Nichols
Oct. 15/08
Bojan Drobic
A continuous assay for the measurement of electrophoretic mobility and
catalytic activity of single molecules of beta-galactosidase.
MSK1 Function
Oct. 22/08
Yanmin Yang
Controlled release of proteins from alginate hydrogel: an in vitro study
Oct. 29/08
Neural Tube Defects: Past Achievements and Present Challenges
Nov. 5/08
Dr. Jane Evans,
Professor, BMG and Dr.
Carol Schneider
Behzad Yeganeh
Nov. 12/08
Josette Douville
Meox2 regulation of target gene transcription in endothelial cells
Nov. 19/08
Shannon Baxter
Prox1 mediated regulation of Cyclin E1 transcription
Nov. 26/08
Sara Beiggi
Interaction of Bcl-2 family members in breast cancer
Dec. 10/08
Dr. Emma Frost
Navigating the Tokyo Subway – The intricacies of intracellular signaling
Mar. 19/08
Mar. 26/08
Apr. 2/08
Apr. 9/08
Apr. 16/08
Apr. 23/08
Non-small cell lung cancer in transgenic mice over-expressing Calreticulin
Page 27 of 35
Courses
Undergraduate
Course
BGEN 3020
BGEN 4010
Description
Co-ordinator
Introduction to Human Genetics
Principles necessary to understand and study genetically controlled
malformations and diseases and variation in individuals and in populations.
Two terms. Lectures, tutorials and assignments. Held at Fort Garry Campus.
Project Course in Human Genetics
A research project chosen in consultation with and supervised by a Faculty
member. A written report is required. The course is available primarily to final
year Honors student in the Honors Genetics program
Dr. D. Merz
Dr. D. Gietz
Graduate
Course
Description
Co-ordinator
BGEN 7000 (M.Sc.)
BGEN 8000 (Ph.D.)
Research Seminar
A one credit pass/fail course. Consists of the presentation on the student's
current research. All registered graduate students in Biochemistry & Medical
Genetics MUST present (“writing” is no longer an exemption) 1 Credit Hour
Principles and Practice of Human Genetics
Lectures, tutorials and assignments designed to review major topics in human
genetics and give practical experience in the analysis and interpretation of
human genetics data and critical review of published work. 3 Credit Hours
Genetic Epidemiology Of Human Populations
Lectures, tutorials and assignments to evaluate the etiology, distribution and
control of disease in groups of relatives and inherited causes of disease in
populations. Prerequisite: BGEN7090 or consent of Instructor. 3 Credit
Hours
Clinical And Molecular Cytogenetics
Cytogenetic methodology; chromosome architecture; karyotype
interpretation; indications for referral; chromosome syndromes and
anomalies; prenatal diagnosis; chromosomal basis of oncogenesis; flow
cytometry; immunogenetics; fluorescent in situ hybridization; the application
of molecular technology to chromosome analysis. Prerequisite: BGEN7090
or consent of Instructor. 3 Credit Hours
Topics in Biochemistry 1
Advanced study and reading on two topics chosen by the course director in
consultation with the student's supervisor. Topics include but are not limited to
Neurochemistry, Lipids, Carbohydrates, Biomembranes, Inborn Errors,
Cystoskeleton Proteins. 3 Credit Hours
Topics in Biochemistry 2
Advanced study and reading on two topics chosen by the course director in
consultation with the student's supervisor. Topics include but are not limited to
Neurochemistry, Lipids, Carbohydrates, Biomembranes, Inborn Errors,
Cystoskeleton Proteins. 3 Credit Hours
Gene Expression Three hours per week, one term. Chromatin structure.
Structure and function of sequence-specific DNA binding proteins. Control of
transcription. 3 Credit Hours
Dr. E. Leygue
BGEN7090
BGEN 7130
BGEN 7180
BGEN 7200
BGEN 7210
BGEN 7250
Dr. B. Chodirker
Dr. J. Evans
Dr. A. Dawson
Dr. G. Arthur
Dr. G. Arthur
Dr. J. Davie
Page 28 of 35
IMED 7090
Cell Biology
Comprehensive introduction to the structure and function of cells.
Prerequisite: consent of instructor. 6 Credit Hours
Neuroscience
An interdepartmental multidisciplinary course providing a comprehensive
overview of cellular, molecular, developmental and systems neuroscience, as
well as the neurobiology of disease. Emphasis will be placed on the
application of the fundamental principles of neuroscience to contemporary lab
research. ANAT 7270 (or 080.727) (offered in alternate years) will provide
instruction in neuroanatomy and structure-function in the nervous system.
Prerequisite: consent of instructor. 6 Credit Hours
Nucleic Acids: Manipulations, Structure and Function
DNA technology; nucleic acid metabolism, including DNA replication, DNA
repair, transcription, and RNA processing; gene/chromosome structure and
rearrangement; mutation detection; gene therapy; positional cloning. 3 Credit
Hours
Developmental Biology
Emphasizes current principles of organ system development and its
application to transgenic approaches to gene function in the context of a
whole, developing organism. Prerequisites: IMED 7090 (or 165.709) or ZOOL
2150 (or 022.215) and/or ZOOL 3070 (or 022.307) or consent of instructor. 3
Credit Hours
Dr. R. Shiu
Course
Description
Co-ordinator
IMED 7300
Microscopy, Optics, Imaging and Analysis in Health Research
Theory and practice of modern microscopy, optics, molecular imaging, and
analyses used in health research. Participants will gain in depth knowledge
through seminars by local and external experts in the field and by hands-on
laboratory work in preparing samples for imaging and analyses. Images will
be acquired using equipment at the Genomic Centre for Cancer Research and
Diagnosis at the Manitoba Institute of Cell Biology. Students will also
participate in interactive tutorials and journal club. 3 Credit Hours
Advanced Molecular Imaging
Seminar course in which students will learn about innovative methods and
advanced analyses of molecular imaging in biomedical research including 2dimentional and 3-dimensional fluorescent in situ hybridization, live-cell
imaging, spectral imaging, and multi-colour imaging. Students will participate
in hands-on laboratory exercises, interactive tutorials and journal club. 3
Credit Hours
Functional Genomics and Whole Genome Analyses
Seminar course in which students will learn about functional genomics and
approaches to whole genome analyses using array technologies. Course
content will be delivered by local and external experts in the field. Students
will participate in hands-on laboratory exercises with micro-array platforms
and computer-based data analyses, interactive tutorials and journal club. 3
Credit Hours
Dr. S. Mai
IMED 7100
IMED 7240
IMED 7290
Dr. D. Eisenstat
Dr. L. Murphy
Dr. G. Hicks
Workshops
IMED 7302
IMED 7304
Dr. S. Mai
Dr. S. Mai
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Medical Teaching 2008 2009
Block 1
Structure Function
(Dr. M. Torchia)
Lectures (Dr. Francis Amara)
SF002
SF003
SF004
SF005
SF006
SF008
SF010
Cytogenetics (DG)
Introduction to Biomolecules (FA)
Proteins (FA)
Molecular Genetics – Protein Synthesis (DG)
Mol Genetics – Disease Mechanisms (DG)
Biomembranes (FA)
Enzymes (FA)
Tutorials
SF007 Genetic Defects (SP)
SF012 Marker Enzymes (FA)
SF015 Acid Base Disturbances (FA)
SF013
SF014
SF016
SF018
SF022
SF033
SF035
Bioenergetics (FA)
Metabolism – Carbohydrates (FA)
Metabolism – Lipids (FA)
Metabolism – Proteins (FA)
Metabolism – Integration (FA)
Med Genetics – Developmental (DG)
Med Genetics – Diagnosis and Treatment (DG)
SF017 Regulation of Gluconeogenesis (BTR)
SF021 Antineoplastic Drugs (FA)
SF029 Fluid Balance (FA)
Problem Solving
PR001 to PR012 (FA, DG, SP)
Assigned Studies
SF001 Mendelian Genetics (DG)
SF011 Clinical Enzymology (FA)
SF020 Metabolism – Purines & Pyrimidines (FA)
SF023 Extracellular Messengers – Hormones (FA)
SF024 Membrane Signal Transduction (FA)
SF025
SF026
SF027
SF028
SF036
Protein Processing (SP)
Intracellular Signalling (FA)
Vitamins & Minerals (FA)
Trace Minerals (FA)
Medical Genetics – Case Study (DG)
Lectures
HD007 Newborn Screening (AM)
HD011 Clinical Cytogenetics 2 (RR)
HD013 Birth Defects (AM)
HD014 Teratogens (AC)
HD018
HD037
HD096
HD125
Variations in Inheritance Patterns I (SM)
Variations in Inheritance Patterns II (SM)
Multi-factorial Disorders (JE)
Clinical Cytogenetics 1 (RR)
Lecture Demonstration
HD005 Genetic Prenatal Diagnosis (BC)
HD102 Genetic Screening (CG)
Block 2
Human Development (Dr. E. Gill)
Tutorials
HD012 Genetic Disease – History Taking (BC)
HD099 Genetic Counselling II – Couple & Family (AC)
Clinical
Dysmorphology
&
Cytogenetics
(AC)
HD017
HD103 Genetic Counselling III – Couple & Family (AC)
HD038 Variations in Inheritance Patterns III (FA)
HD120 Population Genetics and Screening (JE)
Page 30 of 35
Problem Solving (Dr. D. Merz)
PR001 to PR009
Assigned Studies
HD094 Genetic Counselling I: Couple & Family (AC)
Block 3
Respiratory (Dr. Z. Bshouty)
Lecture
RS079 Genetics of Respiratory (BC)
Cardiovascular (Dr. A. Soni)
Lecture
CV075 Genetic Aspects of Cardiomyopathy (AC)
Lab Medicine Tutorials
LM008 Use of Genetic Diagnostic Labs in Med.
(BS)
Block 4
Reproduction (Dr. M. Morris)
Lecture
RP049 Perinatal Genetics (BC)
Kidney (Dr. K. Bernstein)
Tutorials
KD005 Heredity: The Genito-Urinary Tract I (JE, PB)
KD017 Energy and the Kidney (SP)
Block 5
Neurosciences (Dr. B. Anderson)
Lecture
NE077 Genetics in Neurology (BS)
Musculoskeletal (Dr. A. Casey)
Lecture
MS076 Genetics of Musculoskeletal (CG)
Page 31 of 35
Lab Medicine Tutorials
LM208 Genetic Lab Diagnosis of NMD (BS)
Block 6
Gastroenterology (Dr. D. Duerksen)
Lecture
GI047 Colorectal Carcinoma I: Genetics (CG)
Blood & Lymph (Dr. D. Houston)
Assigned Reading/Studies
BL002 Hematopoiesis: Molecular I (FA)
BL036
Lymphocytes and Apoptosis (SG)
Tutorials
BL004 Hematopoiesis: Molecular II (FA)
BL008 Globin Gene Disorders (BTR)
BL025 Gene Therapy (FA)
BL049
BL052
Hemochromatosis (FA)
Coagulation Testing (BTR)
Instructor Key
Francis Amara (FA)
Gilbert Arthur (GA)
Shannon Chin (SC)
Bernie Chodirker (BC)
Ab Chudley (AC)
James Davie (JD)
Angie Dawson (AD)
Hao Ding (HD)
Scarlett Drescher (SD)
Alison Elliott (AE)
Jane Evans (JE)
Spencer Gibson (SG)
Dan Gietz (DG)
Cheryl Greenberg (CG)
Geoff Hicks (GH)
Etienne Leygue (EL)
Aziz Mhanni (AM)
Sandra Marles (SM)
Nasrin Mesaeli (NM)
David Merz (DM)
Michael Mowat (MM)
Leigh Murphy (LM)
Steve Pind (SP)
Reena Ray (RR)
Beth Spriggs (BS)
Barb Triggs-Raine (BTR)
Jeffrey Wigle (JW)
Klaus Wrogemann (KW)
Page 32 of 35
Review of Operations
Operating Budget
Research Funding
Page 33 of 35
Grant Support by Faculty Member, and Source
PRINCIPAL
INVESTIGATOR
:
ARTHUR
CHOY
DAVIE
DING
GIBSON
GIETZ
HICKS
LEYGUE
MERZ
MESAELI
MOWAT
MURPHY
SIMARD
TRIGGS-RAINE
WIGLE
WROGEMANN
Total per Agency:
CFI
72,000
CIHR
CRC
NCIC
NRC
NSERC
GC
73,802
58,352
152,549 200,000 118,059 147,721
36,986 100,000 79,511
123,248
TOTAL
PER P.I.
Other*
20,000
185,000
73,802
58,352
690,329
236,497
308,248
30,000
1,279,360
187,077
111,316
87,500
131,200
258,438
140,270
320,095
302,392
131,451
(BI)
(CBCF, LLSC, MHRC Chair)
30,000
456,039 100,000
16,083
11,316
130,161
69,992
563,479
89,850
(CBCF, MHRC, CIHR/MHRC-RPP)
100,000
(CIHR/MHRC-RPP)
87,500
(MHRC, HSFM, TF)
131,200
128,277
140,270
72,000
(AIBS, STEM)
170,994
264,032
100,122
106,370
131,451
1,554,141 400,000 633,409 147,721
(CIHR/MDC/ALS-NRP, FSMA, WI)
56,063
(CIHR/MHRC-RPP)
95,900
(HSFM, MHRC, MHRC Chair)
30,000 563,479 945,577
0
4,346,327
Federal:
CFI
Canadian Foundation for Innovation
CIHR Canadian Institute of Health Research
CRC
Canada Research Chair
NCIC National Cancer Institute of Canada
NSERC Natural Sciences and Engineering Research Council of Canada
GC
Genome Canada
*Other:
AIBS Allan Institute for Brain Science
ALS
Amyotrophic Lateral Sclerosis Society of Canada
BI
Boehringer Ingelheiim
CBCF Canadian Breast Cancer Foundation
FSMA Families of Spinal Muscular Atrophy
HSFM Heart and Stroke Foundation of Manitoba
LLSC Leukemia and Lymphoma Society of Canada
MDC Muscular Dystrophy of Canada
MHRC Manitoba Health Research Council
STEM Manitoba Science, Technology, Energy & Mines
TF
Dr. Paul H. T. Thorlakson Foundation Fund
WI
Westat Inc.
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