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Danyal Education Cell Division Notes 1 UNIT14: CEtT DIUISI()N Learning Objeclives State the importance of mitosis Explain the need for the production of genetically identical cells Identify the main stages of mitosis and meiosis Define haploid and diploid Slate how meiosis andfertilisation can lead to vqriation n a g g gl g . . . uc ati o MrTosrs Mitosis is a type of cell division which involves the division of the nucleus daughter cells. to produce two The daughter cells have the same number and same kind of chromosomes as the parent cell. The importance of mitosis: ,/ ,/ ./ ./ Produces new cells for growth, repair and replace damaged or dead cells in multicellular organisms A form of asexual reproduction in unicellular organisms Ensures genetical identical of the offspring or new cells to the parent Preserves the diploid number of chromosomes ,/ ,/ '/ Ed The cell cycle is the order of events that occurs between one cell division and the next. lt comprises of the following events: lnterphase Mitosis Cytokinesis cytokinesis interphase A cell spends about 90% of the cycle during interphase. lt is the non-dividing period. The cell carries out regular cellular activities such as synthesising new proteins for growth. ln interphase, the chromosomes are not visible which appear as long thread-like structures called al chromatin. Centrioles in animal cell duplicate at this stage. Plant cells do not have centriole. During interphase, just before mitosis takes place, the cell will then duplicate the chromatin threads into two identical threads. ny a Mitosis is a process of cell division which results in the production of two daughter cells from a single parent cell. The daughter cells are identical to one another and to the original parent Da cell. I chromosome tt parent cell \ I\ I TI t replication of DNA mitosis two identical daughter cell \ / (\ C J :r e @ SIM Pte ltd BIOLOGY O Level Conceptual Learning I l{f a The daughter cells are diploid (2n) i.e. they have the complete number of chromosomes and are genetically identical to the parent cell. a Cytokinesis refers to the process whereby the cytoplasm of daughter cells split off completely from each other after cell division. Mitosis in animals Decription Name The chromatin, diffuse in interphase, condenses into chromosomes, which are now visible under a microscope. Each chromosome has duplicated and now consists of two sister chromatids attached at the centromere. At the end of prophase, the nuclear envelope breaks down into vesicles. Ed uc ati a on Stoges of mitosis microtubules (spindle fibres) Prophase centromere nuclear envelope equator The chromosomes align at the equator of the spindle. They are held in place by microtubules attached to the mitotic spindle and to part of the & Metaphase pole centromere. Da n Anaphase ya l separated chromosome a chromosome uncoiling 250 The centromeres divide. Sister chromatids separate as the spindle fibres pull them apart and move toward the opposite poles. Once separated, the chromatids are known as daughter chromosomes. Daughter chromosomes arrive at the poles and the microtubules d isa ppea r. Telophase Cytokinesis a nuclear membrane reforms The chromosomes uncoil and lengthen to become thin chromatin threads again and the nuclear envelope reappears around them. The cytoplasm divides. The cell membrane pinches inward ultimately to produce two daughter cells @ Gl"M Pte ltd Mitosis in plants . . . Centrioles are absent in plant cells. The cytoplasm does not pinch inwards during cytokinesis. plate by the fusion of vesicles at the equator of the cell. lt starts with the formation of cell A new cell wall is formed between the two daughter nuclei which divides them into two. cell wall cell plate uc ati o n new cell wall nucleus vesicle @ REVlStoll What is mitosis? Ed 1. (a) I Where does mitosis take place in humans? (c) The diagram below shows the summary of mitosis. Complete the diagram to show how a parent cell produces two daughter cells. Da ny al (b) /t (( parent cell + mitosis replication of DNA two identical daughter cell tt O 0LM Pte Lld BIOLOGY O Level Conceprual Learning I igl 2. The diagram shows the cell cycle. The cell cycle consists of three stages. ati o o (a) Name the other two stages shown in the diagram. a P State the main event that takes place during process (c) State how process Q is important for the cell cycle. in mitosis in the correct sequence after process Q. The diagrams below show the cell at different stages during mitosis. Label the structures A-l al 3. P. Ed uc (b) (d) Name all the processes n P F A E ny G B H Da c D A B C D E F G H O 252 GLM Pte ltd How does the mitosis in a plant cell differ from that in an animal cell? 5. Why is mitosis important to plants and animals? Give two reasons uc ati on 4. MEIOSIS . Meiosis involves a reduction in the amount of genetic material. Meiosis comprises two successive nuclear divisions, meiosis round of DNA replication. I and meiosis Il, with only ,/ meiosis meiosis ny al Da diploid (2n) parent cell I \ ,/ + one Ir Ed . . . Meiosis is the process by which a single parent diploid cell divides to produce four daughter haploid cells. Haploid cells contain half the number of chromosomes as the parent nucleus. Meiosis is the type of cell division by which gametes (eggs and sperm) are produced. I \ // replication of chromosomes meiosis ll \ four haploid (n) daughter cells Each nuclear division consists of four phases. Meiosis Meiosis ll I Prophase Prophase ll I Metaphase I Metaphase ll Anaphase I Anaphase ll Telophase I Telophase ll 6 O 6lM Pte ltd BIOLOGY O LevelConceprual Learning | !$$ During interphase '/ '/ The chromosomes are not visible. They have thread-like structures called chromatin. The chromosomes replicates to form two identical sister chromatids joined at the centromere. ,/ The centriole replicates. Meiosis ati on The replication of chromosomes only takes place during interphase. No replication of chromosomes in meiosis I and meiosis ll. I Name Decription Duplicated chromatin condenses. Each chromosome consists of two, closely associated sister chromatids. Homologous chromosomes; one from the male parent and one from the female parent, pair up along their whole length. This is called synapsis. Crossing over can occur during this stage of prophase l. Centrioles move to the opposite poles of the cell and each chromosome is now 2 chromatids joined together at the centromere.. The chromatids may cross and twist around each other, causing them to break and exchange parts. The point where they cross each other is called a chiasma (plural: chiasmata)This is crossing over and it produces genetic variations in germ cells. centriole l{ Prophase I J uc a pair of homologous chromosomes Metaphase Da ny I al Ed chiasma Anaphase Telophase 254 I I Homologous ch romosomes align themselves at the equator. a The paired homologous chromosomes separate from each other. Each chromosome moves to the opposite pole of the cell. Each chromosome contains two chromatids. nuclear membrane Nuclear membrane forms around the chromosomes at each pole and the cytoplasm divides. Two daughter cells are formed. Each daughter cell contains only haploid chromosome set. O 6LM Ple ltd Meiosis ll Decription Name DNA does not replicate. Centrioles move to opposite poles, spindle fibres appear and nuclear envelope breaks down. ati on Prophase ll Chromosomes align themselves at the equator. Centromeres divide and sister chromatids migrate separately to each pole. ll ? Ed Anaphase uc Metaphase ll al Telophase ll Cell division is complete. Spindle fibres disappear and nuclear membrane form around the daughter chromosomes at each pole. Four haploid daughter cells are obtained. ny 8 nuclear membrane Da ln conclusiorr, meiosis differs from mitosis in that there are two cell divisions in meiosis, resulting in cells with a haploid number of chromosomes. The importance of meoisis: Factor To ensure Explanation a trait inheritance in offspring a Meiosis allows the transmission of traits found in the genes from one generation to the next. The traits from the parents can be passed on to the offspring during fertilisation when the gametes from both parents fuse together. c ;3 e @ GLM Pte l-td BIOLOGY O Level Conceptuat Learning I l!! Genetic variation in gametes is caused by the random distribution of the pair of homologous chromosomes from either the male or the female during meiosis l. Hence, there is a possible of large number of different chromosomes combinations during fertilisation. During meiosis, crossing over of chromosomes allows the exchange of genetic materials between the pair of homologous chromosomes. As a result, it increases the chance of genetic variation among offspring. To produce n offspring with genetic variation production of haploid gametes To produce offspring with better chance of survival a ca tio Meiosis process produces the haploid gametes. During fertilisation, the fusion of the haploid gametes enables the restoration of diploid chromosomes in the species. To ensure the Meiosis allows the selection of better and stronger traits or characteristics from one generation to the next. The favourable characteristics ensure the offsprings to have a better chance of survival in the changing environmental conditions. Mitosis Ed u DIFFERENCES BETWEEN MITOSIS AND MEIOSIS Homologous chromosomes do not pair up Homologous chromosomes prophase at Daughter cells are completely identical to parent cells Daughter cells may contain variations from parent cells Two daughter cells produced from one Four daughter cells produced from one parent cell parent cell Daughter cells have same number of chromosomes (diploid number) as parent Daughter cells have half the number of chromosomes (Haploid number) as the cell parent cell 0nly one nuclear division involved Two nuclear divisions involved ny al Crossing over may occur 2 Da What is meiosis? (b) Explain the following (i) Haploid cell (ii) 256 pair up I Crossing over does not occur OREUISION L. (a) Meiosis terms. Diploid cell o GLM Pte ltd (c) The diagram below shows the summary of meiosis. Complete the diagram to show how a parent cell produces four daughter cells. ,r' meiosis ll n \ ,r' \ parent cell replication of chromosomes I ca tio meiosis -----) ,r' meiosis ll \ 2. l E du four daughter cells The diagram shows the cell in one of the stages during meiosis. rlr, -0 Name the stage shown in the diagram. Da (a) -rl ny a >0- (b) what has taken place at point X? Explain its significance for this event. (c) What is the next stage that would happen to this cell? C ;r e O OtM Fte ltd BIOLOGY O LevelConceptual Learning I l!/ n o 3. (a) List one similarity between anaphase I and ll (b) List one difference 4. i t a c u d between anaphase I and ll State four differences between mitosis and meiosis 5. (a) (b) E l a y n a Why is meiosis important for organisms that reproduce sexually? What is the advantage of meiosis for living organisms? D Topical Practice Questions 14 Section A: Multiple-Choice Questions L. Which of the following best describes the process whereby the cytoplasm of daughter cells split off completely from each other after cell division? A prophase 2 B anaphase C metaphase D cytokinesis Which of the following stages occurs when centromere divides and sister chromatids migrate separately to each pole during meiosis? A 258 Anaphase I B Anaphase ll c Metaphase I D Metaphase ll O GLM Ple ltd