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Quarterly Summary Report Third Quarter – 2015 (Jul-Sep) Volume 6; Issue Number 3; 2015 Communicable Diseases Bulletin www.haad.ae Table 1: Notified cases in Abu Dhabi Emirate by Region (Q3, 2015) Quarter 2 2015 Cases Table of Contents Item Content I Notified cases in Abu Dhabi Emirate by region (Quarter 3, 2015) 3 Notified cases in Abu Dhabi Emirate by age and gender (Quarter 3, 2015) 4 Monthly trends for selected notified diseases in Abu Dhabi Emirate (Q 3 /2015 Vs Q 3 /2014 and 2013) 5 Visa screening applicants in Abu Dhabi Emirate (Q 3 /2015) 6 II III IV V VI Page 7-10 Sharing Reports: HAAD Immunization Information System (IIS) 11-13 VII Activities 14 VIII Flash news 15 IX The volume: “Flash- on-an-Illness”: Leprosy 16-18 2015 TOTAL 2014 2013 Year Total Q1 Q2 Q3 Q1+Q2 +Q3 Q1+Q2 +Q3 Q1+Q2 2014 2013 AFP * 2 0 0 2 1 2 5 6 8 7 10 Brucellosis 10 20 1 10 25 31 66 38 86 49 99 Chickenpox 705 103 52 1415 1312 860 3587 3575 3770 4660 4581 2 0 0 0 1 2 3 3 2 3 2 111 9 15 73 204 135 412 293 592 360 675 Haemophilus influenzae invasive 0 0 0 0 0 0 0 0 1 1 1 Hepatitis A 30 7 4 58 31 41 130 156 206 224 271 Hepatitis B 238 53 17 233 275 308 816 576 534 818 699 Hepatitis C 176 27 0 185 197 203 585 414 409 570 546 Influenza 103 35 4 772 341 142 1255 1089 257 1499 410 Malaria * ¶ 521 328 82 159 383 931 1473 1863 1602 2415 2203 Measles * 6 5 0 36 54 11 101 112 53 117 122 Meningitis (bacterial) 11 1 0 20 11 12 43 32 28 38 33 Meningitis (viral) 14 1 3 14 11 18 43 39 46 56 59 Mumps 39 6 3 50 73 48 171 138 139 182 174 Pertussis 6 2 1 4 3 9 16 11 30 15 38 Rubella * 19 1 0 26 84 20 130 10 13 10 15 Scabies 243 51 5 554 372 299 1225 1123 707 1475 1001 Shigellosis 5 1 0 7 3 6 16 14 12 14 17 Tetanus 0 0 0 0 0 0 0 1 1 1 2 Tuberculosis (Pulmonary) * 41 17 6 112 85 64 261 249 329 338 311 Tuberculosis (Extra-Pulmonary) 36 18 2 52 57 56 165 146 130 205 169 Typhoid /Paratyphoid 54 13 10 67 67 77 211 160 198 222 248 Rotavirus 48 63 12 216 208 123 547 514 631 615 864 Other diseases 444 160 27 840 777 631 2248 1532 1320 2032 1607 Total 2864 921 244 4905 4575 4029 13509 12094 11104 15926 14157 Grand total including all ruled out notifications 3352 1030 335 5755 5400 4717 15872 14455 12345 18705 16122 Cholera Foodborne illnesses ** Topic of the volume: Sexually Transmitted Infections (STIs) Abu Eastern Western Dhabi Region Region Cumulative in Abu Dhabi Emirate Illnesses covered by national control programs (only confirmed cases and cases that cannot be ruled out are included in the table) Foodborne illnesses (FBI) other than those specified in the list FBI includes: Salmonellosis, Campylobacteriosis, Adenovirus and Clostridium. ¶ All notified malaria cases are “imported” Indicates increase or decrease in number of notified cases during the 3rd quarter of 2015 compared to previous quarters Indicates increase or decrease in numbers of notified cases over Q1-Q3 2013 as compared to the previous two years Page 2 Quarterly Summary Report: 3nd Quarter - 2015 Quarterly Summary Report: 3nd Quarter - 2015 Page 3 Chickenpox declined in 3rd quarter in consistence with the previous two years. It could be due to school vacation during this period of time. Total 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 Brucellosis 0 0 0 0 3 1 2 2 11 1 5 1 3 0 0 2 0 0 24 7 31 700 860 600 30 35 42 46 138 18 343 52 95 10 21 0 5 2 0 0 Cholera 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 1 1 0 1 0 688 172 1 69 1 66 2 135 Food Borne Illness 2 Haemophilus influenzae 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Hepatitis A 0 0 3 1 9 7 5 3 8 1 1 1 0 0 1 0 1 0 28 13 41 Hepatitis B 1 2 0 0 1 0 26 5 79 42 54 19 40 7 17 8 2 5 220 88 308 Hepatitis C 1 0 0 0 1 0 12 1 52 11 46 4 35 5 21 10 2 2 170 33 203 7 11 5 9 7 6 33 13 5 7 5 3 0 0 Influenza 0 4 32 32 14 10 5 2 8 5 13 5 6 2 1 1 1 1 80 62 142 Malaria * 0 0 4 6 8 5 281 7 356 8 145 2 82 2 23 1 1 0 900 31 931 Measles * 0 2 2 2 0 0 0 1 1 2 1 0 0 0 0 0 0 0 4 7 11 Meningitis Bacterial 3 0 1 0 2 1 0 0 1 1 1 0 0 1 0 0 1 0 9 3 12 Meningitis Viral 2 4 1 0 1 0 1 0 1 1 4 1 2 0 0 0 0 0 12 6 18 Mumps 1 0 6 4 9 12 2 0 3 3 5 2 0 0 1 0 0 0 27 21 48 Pertussis 1 6 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 7 9 Rubella * 0 0 0 0 0 0 3 2 10 3 1 1 0 0 0 0 0 0 14 6 20 Scabies 2 11 7 62 3 106 15 45 6 18 4 7 1 6 4 2 0 0 257 42 0 0 0 0 0 0 1 1 0 1 2 1 0 0 0 0 0 0 3 3 6 Tetanus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Tuberculosis (Pulmonary) * 1 0 0 0 0 0 7 4 17 4 9 6 5 2 4 2 1 2 44 20 64 Tuberculosis (Extra-Pulmonary) 1 0 0 0 0 0 6 2 23 9 9 4 1 0 0 1 0 0 40 16 56 Typhoid /Paratyphoid Fever 0 0 1 3 3 1 10 4 20 10 12 1 9 2 1 0 0 0 56 21 77 Rotavirus 10 14 33 28 7 5 1 3 9 3 3 2 3 0 0 2 0 0 66 57 123 Other Diseases 22 13 Total 61 62 170 160 151 139 601 95 1197 295 514 123 259 41 101 36 40 23 35 33 32 30 115 110 57 50 29 13 19 5 3 2 352 279 4717 Grand total The highlighted cells (with red numbers) indicate the age/gender categories that had the largest numbers of reported cases for the given illness. Σ The grand total for Q3 2015 after including all ruled out notifications will be 4717. 2014 500 2015 400 300 200 100 Foodborne Illnesses (after excluding Rotavirus cases) 250 2013 2014 2015 200 150 100 50 0 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan Feb Mar Apr May Pattern of Hepatitis A in Q3 is the same compared to the previous two years. Increased number in this quarter may be associated with the start of the academic year and/or travel history. Hepatitis A 50 45 Jul Aug Sep Oct Nov Dec Influenza notifications started to increase in Q3 following the same pattern of the two previous years. Influenza 500 2013 2014 2015 40 35 30 25 20 15 10 5 (Including influenza A and B only) 450 2013 2014 2015 400 350 300 250 200 150 100 50 0 0 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan Feb Mar Apr May MONTH Jul Aug Sep Oct Nov Dec There is a decline in measles cases in Q3 following same pattern as of previous two years. This was observed in summer time which may be due to school vacation. 40 Malaria 450 Jun MONTH Malaria follows the same trend compared with previous years. All reported malaria cases are imported. 2013 2014 2015 400 Σ Jun MONTH MONTH 631 12 12 3066 963 4029 300 2013 0 299 Shigellosis Chickenpox Number of notified cases 9 Number of notified cases 14 Number of notified cases Chickenpox Number of notified cases AFP * Food borne illness in 3rd quarter is still steady with a minor outbreak reported in AD region. Measles 35 2013 2014 30 350 Number of notified cases Cases Monthly Trends for Selected Notified Diseases in Abu Dhabi Emirate (Q3/2015) Number of notified cases Table 2: Notified cases in Abu Dhabi Emirate by Age & Gender (Q3, 2015) 2015 25 300 250 20 200 15 150 10 100 50 5 0 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 0 Jan Feb Mar Apr May Jun MONTH Page 4 Quarterly Summary Report: 3nd Quarter - 2015 Jul Aug Sep Oct Nov Dec MONTH Quarterly Summary Report: 3nd Quarter - 2015 Page 5 Visa Screening in Abu Dhabi Emirate (Q3-2015) Visa screening is mandatory for all expatriates applying for work and/or residence in Abu Dhabi Emirate. It consists mainly of screening for Human Immunodeficiency Virus (HIV), pulmonary tuberculosis, and leprosy. Screening for Hepatitis B and syphilis are limited to a few occupational categories. HAAD Visa Screening Standard is available online at: http:// www.haad.ae/HAAD/LinkClick.aspx?fileticket=rPUOPzw3_Gw%3D&tabid=820 Around quarter a million people or more apply for visa medical screening every three months in Abu Dhabi Emirate. During the third quarter of 2015, a total of 424,899 applicants were screened at all HAAD-licensed Screening Centers (a total of eleven centers in the three regions of Abu Dhabi). Figure 1: Visa screening applicants during the third quarter. 2015 450000 No. of Applicants 252876 250000 172023 200000 Introduction Sexually transmitted infections (STIs) are a major global cause of acute illness, infertility, longterm disability and death with serious medical and psychological consequences for millions of men, women and infants. The Health Authority Abu Dhabi (HAAD) estimates that nearly 1500 new sexually transmitted infections occur every year in the Emirate of Abu Dhabi. The most widely known are syphilis, gonorrhoea, chlamydia and human immunodeficiency virus (HIV). Many of these are curable with effective treatment, but they continue to be a major public health concern in both industrialized and developing countries. The World Health Organization (WHO) estimates that, globally, more than 340 million new cases of syphilis, gonorrhea, chlamydia and trichomoniasis occur every year in men and women aged between 15–49 years. • More than 1 million people acquire sexually transmitted infection every day. • Each year, an estimated 500 million people become ill with one of 4 STIs: chlamydia, gonorrhoea, syphilis and trichomoniasis. • More than 530 million people have the virus that causes genital herpes (HSV2). • More than 290 million women have a human papillomavirus (HPV) infection. • In pregnancy, untreated early syphilis will result in a stillbirth rate of 25% and be responsible for 14% of neonatal deaths – an overall perinatal mortality of about 40%. 347292 300000 Sexually Transmitted Infections (STIs) Global Figures 424899 400000 350000 TOPIC OF THE VOLUME 150000 77607 100000 50000 0 M Gender F New TOTAL Renewal Visa Status Table 3: Number and prevalence rate of positive cases among new and renewal visa applicants during the third quarter of 2015. Disease Hepatitis B*** Tuberculosis** HIV Leprosy Syphilis*** New Renew New Renew New Renew New Number of Cases 102 9 235 14 119 73 0 0 336 0 Prevalence* 59.3 3.6 709.9 52.3 69.2 28.9 0 0 1105.7 0 Visa Status Overall Prevalence* 26.1 416.0 45.2 Renew New 0 Renew 611.6 * Prevalence: the number of positive cases per 100,000 visa screened applicants ** This refers to active TB cases only *** Applies to tested occupational categories only. Figure 2: Estimated cases of curable sexually transmitted infections (gonorrhoea, chlamydia, syphilis and trichomoniasis) by WHO regions, 2008. Page 6 Quarterly Summary Report: 3nd Quarter - 2015 Quarterly Summary Report: 3nd Quarter - 2015 Page 7 Causative agents and mode of transmission STIs are infections that are spread primarily through sexual contact with an infected person. There are more than 30 different sexually transmissible bacteria, viruses and parasites. The most common conditions they cause are gonorrhoea, chlamydial infection, syphilis, trichomoniasis, chancroid, genital herpes, genital warts, and human immunodeficiency virus (HIV) infection. Several infections, in particular HIV and syphilis, can also be transmitted from mother to child during pregnancy and childbirth, and through blood products and tissue transfer. Treatment of STIs In addition, category of “Others” was added to report any other STIs which are not listed in HAAD electronic system. Health professionals are ethically obligated to protect patient confidentiality. On the other hand CDD should contact the case and make sure he/she is aware of the diagnosis. As well, the case should be educated with regard to mode of transmission and prevention methods of STIs. Both suspected and confirmed STIs should be reported to HAAD through electronic notification system: http://bpmweb.haad.ae//Usermanagement/login.aspx Effective treatment is currently available for several STIs. The infection is easily treated Resistance of STIs—in particular gonorrhoea—to antibiotics has increased rapidly in recent years and has reduced treatment options. The emergence of decreased susceptibility of gonorrhoea to the “last line” treatment option (oral and injectable cephalosporins) together with antimicrobial resistance already shown to penicillins, sulphonamides, tetracyclines, quinolones and macrolides makes gonorrhoea a multidrug-resistant organism. Antimicrobial resistance for other STIs, though less common, making prevention and prompt treatment critical. For more information about common STIs, please refer to CDC/STIs Fact Sheets available at: http://www.cdc.gov/std/healthcomm/fact_sheets.htm. STIs notification in the Health Authority - Abu Dhabi (HAAD) According to the federal law No. 27 of 1981 (and the updated law No. 14 of 2014), STIs are among notifiable diseases which should be reported to communicable diseases department in HAAD. STIs can be reported within seven days after identifying the case. List of STIs that must be reported include: Chlamydia Chancroid Gonorrhea Genital Warts Herpes Simplex Syphilis Trichomoniasis Page 8 Screening programs for STIs in Abu Dhabi: • Antenatal screening of pregnant women for: syphilis, hepatitis B and HIV. • Premarital screening for: HIV, Hepatitis B, human papilloma virus (HPV) and Syphilis. • Screening of Visa applicants for HIV, Syphilis and Hepatitis B (two latter diseases for certain job categories of applicants). • Pre-employment screening for HIV and Hepatitis B. Statistical figures from HAAD ID notification system 469 500 367 400 No. of reported cases with antibiotics, but can lead to serious long-term health problems if left untreated, including infertility. Three bacterial STIs (chlamydia, gonorrhoea and syphilis) and one parasitic STI (trichomoniasis) are generally curable with existing, effective single-dose regimens of antibiotics. For herpes and HIV, the most effective medications available are antivirals that can modulate the course of the disease, though they cannot cure the disease. For hepatitis B, immune system modulators (interferon) and antiviral medications can help to fight the virus and slow damage to the liver. 300 251 173 200 100 0 2011 2012 2013 2014 Figure 3: Reported Cases of STI’s between 2011 and 2014 in Abu Dhabi Emirate. Quarterly Summary Report: 3nd Quarter - 2015 Quarterly Summary Report: 3nd Quarter - 2015 Page 9 Sharing Reports HAAD Immunization Information System (IIS) No. of notified cases 250 200 150 Chlamydia Cases Gonorrhea Cases 100 Syphilis Cases 50 0 Y2011 Y2012 Year Y2013 Y2014 Figure 4: Reported Cases of Chlamydia, Gonorrhea, and Infectious Syphilis (2011-2014) Abu Dhabi Emirate [Note that some of reported syphilis cases received from blood bank]. Vaccination is one of the most effective public health interventions available and save 2–3 million lives per year worldwide. Most vaccines in use today provide high levels of individual protection against disease. In addition, most Vaccine Preventable Diseases (VPDs) are spread from infected people to susceptible people. When high levels of immunity are achieved by vaccination in a community, a person with VPD is unlikely to encounter a susceptible host. Consequently transmission is blocked and exposure of others in the community who are not protected by vaccination will be prevented. In the Emirate of Abu Dhabi, high vaccination rates have been reached for many recommended vaccines, leading to the near elimination of the corresponding vaccine preventable diseases listed in table 5. While this reduction in VPDs demonstrates the great success of vaccines and the efforts of all the entities involved in vaccination programs in the Emirate of Abu Dhabi, there is still work to be done. Table 4: Reported cases and rates (per 100,000 population) of vaccine preventable diseases (2011 – 2014) in Abu Dhabi emirate: Cases Rates per 100,000 Population % of notified cases Disease Hepatitis B 50% 45% 40% 35% 30% 25% 20% 15% 10% 5% 0% Diphtheria Pertussis Chlamydin Genital Warts Polio Gonorrhea Haemophilus influenza type B Herpe Simplex 0-14 15-19 20-24 25-29 Age group 30-39 Tetanus 40+ Figure 5: Distribution of Sexual Transmitted Infections by Age Group in Abu Dhabi Emirate (2011-2014). Invasive Pneumococcal Disease (IPD) Rota Virus Measles Mumps Rubella Chickenpox Page 10 Quarterly Summary Report: 3nd Quarter - 2015 Quarterly Summary Report: 3nd Quarter - 2015 Page 11 As the end of 2015 and continuing into 2016, the UAE led by Ministry of Health has been conducting a massive national measles campaign for children 1- 18 years of age with the aim of achieving the measles elimination target for WHO EMRO region (The elimination target is set as <1 case/ million population). The target population for phase 1 is 500,000. Prior to this campaign, Health Authority Abu Dhabi has established an Immunization Information System registry that collects all vaccine information administered in the Emirate of Abu Dhabi which has been integrated electronically with SEHA IT system. HAAD Immunization Information System is a confidential, population based registry that records all immunization doses administered by participating providers to persons residing within the Emirate of Abu Dhabi regions: • At the healthcare provider level, IIS can provide consolidated immunization histories for use by a vaccination provider in determining appropriate client vaccinations. • At the public health level, an IIS provides aggregate data on vaccinations for use in surveillance and program operations, and in guiding public health action with the goals of improving vaccination rates and reducing vaccine-preventable disease. Immunization Information System was developed to achieve the following objectives: 1. National Program Support: HAAD IIS helps local and national immunization programs to identify populations at high risk for vaccine-preventable diseases and target interventions and resources efficiently. 2. Immunization Registry: HAAD IIS is an Abu Dhabi emirate wide immunization registry that collects vaccination history information from different sources into a single record and provides official immunization records for parents or other services that require prove of immunization entry requirements. 3. Public Health Support: HAAD IIS helps the public health team to monitor outbreaks and adverse events related to vaccines. IIS ensures that healthcare providers do follow the most up-to-date recommendations for immunization practice. 4. Timely Immunization: HAAD IIS reminds families when an immunization is due or has been missed. 5. Parents Support: HAAD IIS help providers and parents to determine when immunizations are due and help ensure that children get only the vaccinations they need. 6. Healthcare Provider’s Support: HAAD IIS is capable of exchanging immunization information with immunization healthcare providers. Data exchange between IIS and other information systems helps ensure timely immunizations, consolidation of records, and allows immunization providers to work more efficiently. Vaccine Administration by Category Abu Dhabi: January 1st to September 30, 2015 Healthcare Provider’s Support Parent’s Support Immunization Program Support IIS Timely Immunizaton AD Emirate Wide Registry Puplic Health Support Catch up 38 HPV catch up 56 Premarital screening program 674 >=65 735 Travelers 1.228 Contacts 1.821 Diabetics 5.361 Chronic Diseases 5.716 Healthcare Professionals 5.954 Others 23.121 Newborn Screening Program 25.197 Hajj and Umra Figure 6: HAAD IIS goals. 10.772 Others Hight Risk Conditions School 53.393 127.426 Expanded Immunization Program 385.136 Figure 7: Vaccine administration by category from January 1st to September 30th 2015. Expanded Immunization Program including all children from birth till the age of preschool [Note that numbers indicated in the graph are encounters/notifications, it is not coverage]. Page 12 Quarterly Summary Report: 3nd Quarter - 2015 Figure 8: HAAD childhood, school and adult immunization schedule. Quarterly Summary Report: 3nd Quarter - 2015 Page 13 Activities 1. Infectious Diseases Notification (IDN) Education program • Six series of training sessions were conducted in some of the private hospitals and clinics to enhance the ID notification awareness among their Health care workers. • The whole program was attended by 112 healthcare workers of different job professions from the targeted healthcare facilities. 2. Malaria Prevention for Travelers • Three training sessions about malaria prevention for travelers from UAE were conducted during Q -3 at the three regions of Abu Dhabi Emirate, to educate healthcare professionals on the ABC’s of malaria prevention to different malaria endemic countries and to discuss drugs used for malaria prevention in special groups of travelers. • A total of 120 participants attended these sessions from different job professions working at SEHA and private HCFs in Abu Dhabi emirate. 3. Awareness session on Malaria Control Processes in farms • One awareness session was conducted in Al Ain to educate Agricultural Extension Workers on mosquitos’ habitat in farms and advise to farms workers and owners. • 60 technical staff and supervisors at Farmers Services Center in Al Ain attended this awareness session. 4. Updates on STIs and HIV management, control and counseling workshop: • The objective of this workshop was to update the target audience about the global and national epidemiology of HIV, to present the updated management protocols of HIV and STIs, to explore the current situation in reporting STIs from HCFs and to discuss the best approaches in counselling and breaking bad news in newly reported HIV and other STIs. • A total of 108 Healthcare professionals who work in different private and public HCFs in Abu Dhabi emirate attended the workshop. 5. Training workshop on Strengthening TB reporting and management in Private HCFs in Abu Dhabi Emirate • The objectives of the workshop were to define the roles and responsibilities of private health care professionals in implementation of DOT standard for TB management, to clarify the requirements for confirmatory tests for TB cases detected in private HCFs and to define challenges in implementation of DOT program and how to deal with them. • The workshop was attended by 82 health care professionals working at private HCFs in Abu Dhabi where TB cases are seen and managed. 6. AFP and measles awareness session: • The objective of this session was to raise the awareness of the participants to detect and report AFP and measles cases to CDD/HAAD. • The session was conducted in Medeor24X7 hospital- Abu Dhabi and attended by (17) HCPs from the nurses and physicians working in the hospital. Page 14 Quarterly Summary Report: 3nd Quarter - 2015 Flash News I- Premarital Screening Reduces Genetic Diseases and Promotes Healthier New Generations Abu Dhabi - July 2015 –HAAD has revealed that since the electronic database of premarital screening was set up, 56,226 people have had screening tests in Abu Dhabi between April 2011 and December 2014 – with more than half of those screened being Emirati. The premarital screening is mandatory for couples who plan to get married in the UAE; in which it is required before a couple can be issued a marriage certificate in the UAE. The screening includes tests for genetic diseases such as: Beta-thalassemia, sickle cell anemia and other hemoglobinopathies. According to HAAD statistics, considerable number of applicants tested positive for genetic diseases and others are carriers. HAAD guides cases that have a history of genetic diseases to consultant specialists to provide advice on genetic diseases, which enables the concerned parties to decide whether or not to undertake the marriage and have children, a step which can have a significant impact in reducing the transmission of genetic diseases down to future generations. II- HAAD opens two new centers for visa screening tests in Abu Dhabi Abu Dhabi - 9 August 2015: HAAD has licensed two new visa screening centers in the emirate; in line with its commitment to provide integrated and efficient healthcare services to the community in all regions of the Emirate. Based on HAAD statistics, 1.4 million individuals benefited from visa screening services in Abu Dhabi in 2014 and 884,000 in the first half of 2015. With the two new centers, there are now 11 visa screening centers in Abu Dhabi Emirate (four in Abu Dhabi, two in Al Ain and five in the Western Region). III- Pilot implementation of first malaria vaccine recommended by WHO advisory groups. GENEVA - The World Health Organization’s Strategic Advisory Group of Experts on Immunization (SAGE) and the Malaria Policy Advisory Committee (MPAC) jointly recommended pilot projects to understand how to best use a vaccine that protects against malaria in young children. “This was a historic meeting with two of WHO’s major advisory committees working together to consider current evidence about this vaccine,” said Professor Fred Binka, acting chair of MPAC. “The committees agreed that pilot implementations should be the next step with this vaccine.” The vaccine, known as RTS,S (trade name Mosquirix), is the first vaccine for malaria, but there is one primary question. It requires four doses for a child to be fully protected and therefore requires additional contacts with the health care system. The first three doses are given one month apart followed by an 18-month pause before the fourth dose. Without the fourth dose, children had no overall reduction in severe malaria. “The question about how the malaria vaccine may best be delivered still needs to be answered,” said Professor Jon S. Abramson, chair of SAGE. “After detailed assessment of all the evidence we recommended that this question is best addressed by having 3-5 large pilot implementation projects.” The malaria vaccine, RTS,S, acts against P. falciparum, the most deadly malaria parasite globally, and the most prevalent in Africa. It offers no protection against P. vivax malaria, which predominates in many countries outside of Africa. The vaccine is being assessed as a complementary malaria control tool that could potentially be added to—but not replace—the core package of proven malaria preventive, diagnostic and treatment measures. Quarterly Summary Report: 3nd Quarter - 2015 Page 15 The volume “Flash-on-an-Illness” Leprosy Background Leprosy is a chronic infectious disease of the skin caused by Mycobacterium leprae, an acid-fast, rod-shaped bacillus. The disease mainly affects the skin, the peripheral nerves, mucosa of the upper respiratory tract and the eyes. There are two different forms of leprosy, tuberculoid (TT) leprosy and lepromatous (LL) leprosy (also called multibacillari (MB) leprosy). The latter is more contagious because the body’s immune system is unable to mount a strong response to the invading organism. Hence, the organism multiplies freely in the skin. Human were thought to be the only reservoir of leprosy, but recent researches found that “feral armadillos” in Louisiana and Texas (USA) were found to be naturally infected with Leprosy which may pose a risk of infection to humans. The incubation period of the leprosy bacillus varies anywhere from six months to ten years. On an average, it takes four years for the symptoms of TT leprosy to develop. Probably because of the slow growth of the bacillus, LL leprosy develops even more slowly, taking an average of eight years for the initial lesions to appear. Elimination of leprosy globally was achieved in the year 2000 (i.e. a prevalence rate of leprosy less than 1 case per 10 000 persons at the global level). The prevalence rate of the disease has dropped in 2000 by 90%: from 21.1 per 10 000 persons to less than 1 per 10 000 persons. Nearly 16 million leprosy patients have been cured with “Multi-Drug Therapy” (MDT) over the past 20 years. National leprosy programs for 2011–2015 now focus more on underserved populations and inaccessible areas to improve access and coverage. Since control strategies are limited, national programs actively improve case-holding, contact tracing, monitoring, referrals and record management. According to official reports received from 103 countries from 5 WHO regions, the global registered prevalence of leprosy at the end of 2013 was 180 618 cases. The number of new cases reported globally in 2013 was 215 656 compared with 232 857 in 2012 and 226 626 in 2011. So far, Leprosy has been eliminated from 119 out of the 122 countries where the disease was considered a public health problem in 1985. Western Pacific - Région du Pacifique occidental, 4596 (2%) African - Région africaine, 20911 (10%) American - Région des Amériques, 33084 (15%) Eastern Mediterranean Région du La Méditerranean orientale, 1680 (1%) South-East Asia - Région du Asie du Sud Est, 155385 (72%) Figure # 9: Distribution of new leprosy cases reported in 103 countries, by WHO Region, 2013. Page 16 Quarterly Summary Report: 3nd Quarter - 2015 Transmission Although not highly infectious, it is transmitted via droplets, from the nose and mouth, during close and frequent contacts with untreated cases. Case Definition Clinical description A chronic bacterial disease characterized by the involvement primarily of skin as well as peripheral nerves and the mucosa of the upper airway. The following characteristics are typical of the major forms of the disease reflecting the cellular immune response to Mycobacterium leprae: 1. Tuberculoid: one or a few well-demarcated, hypopigmented, and anesthetic skin lesions, frequently with active, spreading edges and a clearing center; peripheral nerve swelling or thickening also may occur. 2. Lepromatous: a number of erythematous papules and nodules or an infiltration of the face, hands, and feet with lesions in a bilateral and symmetrical distribution that progress to thickening of the skin. 3. Borderline (dimorphous): skin lesions characteristic of both the tuberculoid and lepromatous forms. 4. Indeterminate: early lesions, usually hypopigmented macules, without developed tuberculoid or lepromatous features Laboratory criteria for diagnosis Any one of the following: • Demonstration of acid-fast bacilli in skin or dermal nerve, obtained either by skin biopsy, slit skin smear examination or nerve biopsy of a lepromatous lesion. • Histopathological report from skin or nerve biopsy compatible with leprosy (Hansen’s disease) examined by an anatomical pathologist or specialist microbiologist experienced in leprosy diagnosis. Case definition Suspected: A clinically compatible case without laboratory confirmation. Confirmed: A clinically compatible case that is laboratory confirmed. Treatment Since 1995, WHO has supplied MDT free of cost to leprosy patients in all endemic countries. The drugs used in WHO-MDT are a combination of rifampicin, clofazimine and dapsone for multibacillary leprosy patients and rifampicin and dapsone for paucibacillary leprosy patients. Among these rifampicin is the most important anti-leprosy drug and therefore is included in the treatment of both types of leprosy. Treatment of leprosy with only one antileprosy drug will always result in development of drug resistance to that drug. Treatment with dapsone or any other antileprosy drug used as monotherapy should be considered as unethical practice. People who are in immediate contact with the leprosy patient should be tested for leprosy. Annual examinations should also be conducted on these people for a period of five years following their last contact with an infectious patient. Some physicians have advocated dapsone treatment for people in close household contact with leprosy patients. Quarterly Summary Report: 3nd Quarter - 2015 Page 17 Some figures from Abu Dhabi Surveillance Data Editorial Board 17 12 No. of notified cases - Dr. Farida Al Hosani (Acting Director / Public Health and Research, HAAD) - Dr. Mariam Al Mulla (Section Head, Communicable Diseases Department, HAAD) - Dr. Ahmed Abdulla (Senior Officer, Communicable Diseases Department, HAAD) - Dr. Badreyya Al Shehhi (Section Head, Communicable Diseases Department, HAAD) - Dr. Kamal Jaafar (Senior Regional Officer, Communicable Diseases Department, HAAD) - Dr. Ahmed Khudhair (Senior Regional Officer, Communicable Diseases Department, HAAD) - Dr. Lamees Abu Haliqa (Senior Regional Officer, Communicable Diseases Department, HAAD) - Dr. Bashir Aden (Senior Officer, Community Health & Surveillance Department, HAAD) - Mrs. Wafa Aldhaheri (Senior Officer, Communicable Diseases Department, HAAD) - Dr. Faiza Ahmed (Sr. Officer / Community Health & Surveillance Department, HAAD) - Dr. Jens Thomsen (Section Head / Environmental Health Section, HAAD) - Mr. Darren Joubert (Sr. Officer/ Occupational & Environmental Health, HAAD) - Dr. Jennifer Moore (Section Head / Maternal & Child Health, HAAD). 13 10 8 2011 2012 2013 Year 2014 30 Sept. 2015 6 9 9 5 4 4 3 3 2 1 1 ES PI IP N EP N A N Nationality 0 L A 0 A ES SR IL NG N SH D LA O 0 IA 0 BA Figure # 11: Distribution of leprosy cases by gender & age in 2014 – 30, Sep. 2015. 1 IL 1 1 PH 2 IA 35 - 44 yrs 6 D 25 - 34 yrs Male Female 2015 till 30 sep 7 D Male Female 2 IN 3 2 2014 8 8 IN 7 6 5 4 3 2 1 0 10 No. of notified cases No. of notified cases Figure # 10: Reported leprosy cases in Abu Dhabi Emirate from 2011 till 30, Sep. 2015. All reported cases were confirmed by histopathological Lab. procedures. Figure 12: Distribution of Leprosy cases by nationality from 2014 – 30, Sep. 2015. Scientific Board - Dr. Iain Blair, Co-Chair (Associate Professor, Institute of public health, UAEU) - Prof. Tibor Pal (Professor, Department of Medical Microbiology, UAEU) - Dr. Agnes Sonnevend (Associate Professor, Department of Medical Microbiology, UAEU) - Dr. Ahmed Al Suwaidi (Consultant Pediatric Infectious Diseases, Assistant Professor, UAEU) - Dr. Rayhan Hashmey (Consultant Infectious Diseases, Tawam Hospital) - Dr. Martin Pitout (Senior Consultant, Microbiologist, SKMC) - Dr. Bashir Aden (Senior Officer, Community Health & Surveillance, HAAD) - Dr. Jamal Al Mutawa (Manager, Community Health and Surveillance Department, HAAD) - Dr. Stefen Weber (Consultant Microbiologist / SKMC) - Mrs. Wafa Aldhaheri, Secretariat (Senior Officer, Communicable Diseases Department, HAAD) We are glad to invite your participation in this bulletin, please contact: Mrs. Wafa Aldhaheri Communicable Diseases Department Health Authority – Abu Dhabi Tel: 037041 130 Fax: 037679 556 Email: [email protected] Tuberculoid Lepromatous indeterminate Not Tested Figure # 13: Distribution of leprosy cases by type of leprosy in 2014 – 30, Sep. 2015. Page 18 Quarterly Summary Report: 3nd Quarter - 2015 Quarterly Summary Report: 3nd Quarter - 2015 Page 19 List of infectious diseases to be notified: