Download Rupert Pearse, Specialist Registrar in Intensive Care Medicine

Curriculum Vitae
Name:
Rupert Mark Pearse
Date of Birth: 30th May 1971
Correspondence address:
Tel: +44 20 3594 0351
Adult Critical Care Unit
Mobile: +44 7718 910440
Royal London Hospital
e-mail:
London E1 1BB
GMC reference: 4307536
[email protected]
CURRENT POSITION
Professor of Intensive Care Medicine,
William Harvey Research Institute, Queen Mary’s University of London
and
Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust.
ROLE
I divide my time equally between my academic work and the clinical care of patients
on the busy intensive care unit at the Royal London Hospital. My central research
interests are in improving clinical outcomes following major non-cardiac surgery and
the cardiovascular management of critically ill and high-risk surgical patients. I have
experience of a wide range of research methodologies including translational
laboratory and clinical research, multi-centre observational and randomised trials and
large epidemiological studies. My current focus is on large clinical studies in perioperative medicine. I am an active member of several national and international
societies for anaesthesia and intensive care medicine. I was recently appointed the
founding director of the National Institute of Academic Anaesthesia UK Perioperative
Medicine Clinical Trials Network. I am active in teaching at undergraduate and
postgraduate level, including co-director of the QMUL Critical Care Medicine MSc
course.
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November 2016
POSTGRADUATE QUALIFICATIONS
May 2011
Founding Fellow of the UK Faculty of Intensive Care Medicine
November 2005
Completion of specialist training
(Intensive Care Medicine and Anaesthesia)
April 2005
Diploma of Intensive Care Medicine (UK)
June 2001
Fellow of the Royal College of Anaesthetists
DEGREES
April 2006
Doctorate of Medicine (MD)
St. George’s, University of London, UK.
June 1996
MB BS
St. George’s, University of London, UK.
June 1993
BSc (Hons) Physiology - First Class.
St. George’s, University of London, UK.
PRIZES & AWARDS
2014
National Institute for Health Research (UK) Research Professorship
2013
National Institute for Health Research (UK) Clinical Trials Fellowship
2012
British Journal Anaesthesia / RCoA Career Development Fellowship
2009
National Institute for Health Research (UK) Clinician Scientist Award
2007
European Shock Society Early Career Investigator Award
2006
European Society of Intensive Care Medicine Research Award
2006
Intensive Care Society Young Investigator Award
2005
Joint 1st prize for poster presentation, International Symposium in
Intensive Care and Emergency Medicine, Brussels.
1993
Rupert Pearse
Physiological Society Prize
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November 2016
CLINICAL TRIALS & HEALTH SERVICES RESEARCH
I play a central and leading role in a range of research streams in peri-operative
medicine, critical care and trauma. These include single and multi-centre clinical trials
and large epidemiological studies involving collaborations across the UK and
worldwide. Key roles in multi-centre studies include:
EPOCH Trial: Randomised stepped wedge cluster trial of a quality improvement
intervention for patients undergoing emergency laparotomy funded by the
National Institute for Health Research (chief investigator)
URL: www.epochtrial.org
ISOS Study: International multi-centre epidemiological study of patients
undergoing non-cardiac surgery funded by Nestle Health Sciences (chief
investigator)
URL: www.isos.org.uk
OPTIMISE Trial: Multi-centre trial of peri-operative haemodynamic therapy
funded by the National Institute for Health Research (chief investigator)
URL: http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=6307
EuSOS Study: European multi-centre epidemiological study of patients
undergoing non-cardiac surgery funded by the European Society of Intensive
Care Medicine and the European Society of Anaesthesiology (chief investigator)
URL: http://eusos.esicm.org/
OPTIMISE II Trial: International trial of peri-operative haemodynamic therapy
funded by Edwards Lifesciences and the National Institute for Health Research
(chief investigator)
METS: International multi-centre UK study of cardio-pulmonary exercise testing
and plasma biomarkers to predict outcome after major non-cardiac surgery (coinvestigator)
PRISM Trial: Randomised trial of CPAP for patients undergoing open abdominal
surgery funded by NIHR and NIAA (chief investigator)
URL: www.prismtrial.org
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November 2016
TRANSLATIONAL RESEARCH
I have a range of translational streams in major surgery, sepsis and trauma. These
include externally funded clinical and laboratory translational research investigating
the effects of adrenergic agents on microvascular and immune function and clinical
engineering projects in the field of cardiovascular monitoring.
LEADERSHIP ROLES
1. Founding director UK Perioperative Medicine Clinical Trials Network (2015- )
2. Member, Executive committee, Health Services Research Centre, Royal College
of Anaesthetists (2011- )
3. Lead, Critical Care & Perioperative Medicine Research Group, QMUL (2014- )
4. Research Lead, Critical Care Service, Barts Health NHS Trust (2010- )
5. Independent steering committee chair NIHR funded MOTION Trial
6. Independent Data monitoring committee chair NIHR funded RESPITE Trial
7. Independent steering committee member NIHR funded HARP II Trial
8. Independent steering committee member NIHR funded PROMISE Trial
National and international societies for anaesthesia and intensive care medicine:
9. Chair, Post-Operative ICU section, European Society of Intensive Care Medicine
(2011-14)
10. Research committee member, European Society of Anaesthesiology (2011-14)
11. Intensive Care sub-committee member, European Society of Anaesthesiology
(2008-2013)
12. Chair, ESA-ESICM joint taskforce to define Post-Operative outcome measures
(2014/15)
National guidelines working groups in critical care and peri-operative care:

Royal College of Anaesthetists Perioperative Medicine Taskforce. Member of
leadership group

Care guidelines for high-risk non-cardiac surgical patients (Department of Health)

Peri-operative fluid management (Various societies including Intensive Care
Society and Royal College of Anaesthetists)

Blood transfusion in critical illness (British Society of Haematology and Intensive
Care Society)
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November 2016
MD(Res)/PhD SUPERVISION
I have supervised three MD/PhDs students to award of their theses. Two more are
now writing up and two are currently conducting research. I have co-supervised three
MD/PhD students to award of their theses and currently co-supervise three in various
stages of their work.
TEACHING
I am actively engaged in both the undergraduate and postgraduate teaching
programmes at my joint institutions. I am co-director of the Critical Care MSc course
now in its fifth year.
INVITED LECTURES
I give around forty invited lectures each year both within the UK and internationally.
Regular fixtures include the European Society of Anaesthesiology annual congress,
European Society of Intensive Care Medicine annual scientific congress, and a
number of meetings arranged by the Royal College of Anaesthetists. I have also
been an invited speaker at national and international meetings throughout the world.
EDITORIAL
I am an Associate Editor at the British Journal of Anaesthesia. I am a section editor
for the new open access journal Peri-Operative Medicine. I was a member of the
editorial board of the Journal of the Intensive Care Society for five years. I was guest
editor for the 2010 and 2014 Peri-Operative Medicine edition of Current Opinions in
Critical Care. I peer review approximately thirty manuscripts a year for various
journals including Intensive Care Medicine, Critical Care, Shock, Anesthesiology,
British Journal of Anaesthesia, British Journal of Surgery, Anaesthesia, Annals of
Surgery, Shock, Resuscitation, British Medical Journal and The Lancet.
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PUBLICATION IMPACT: h-index 27 with 600 citations in 2015 (Web of Science)
ORIGINAL PAPERS
1.
International Surgical Outcomes Study group Global patient outcomes after elective
surgery: prospective cohort study in 27 low-, middle- and high-income countries. Br J
Anaesth. 2016 Nov; 117(5):601-609. PMID: 27799174
2.
Neto AS, Barbas CS, Simonis FD, Artigas-Raventós A, Canet J, Determann RM, Anstey
J, Hedenstierna G, Hemmes SN, Hermans G, Hiesmayr M, Hollmann MW, Jaber S,
Martin-Loeches I, Mills GH, Pearse RM, Putensen C, Schmid W, Severgnini P, Smith R,
Treschan TA, Tschernko EM, Melo MF, Wrigge H, de Abreu MG, Pelosi P, Schultz MJ;
PRoVENT; PROVE Network investigators. Epidemiological characteristics, practice of
ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome
in intensive care units from 16 countries (PRoVENT): an international, multicentre,
prospective study. Lancet Respir Med. 2016 Nov.;4(11):882-893. PMID: 27717861
3.
Pearse RM, Abbott TE, Haslop R, Ahmad T, Kahan BC, Filipini C, Rhodes A, Ranieri M.
Prevention of Respiratory Insufficiency after Surgical Management (PRISM) trial: report of
the protocol for a pragmatic randomised controlled trial of Continuous Positive Airway
Pressure (CPAP) to prevent respiratory complications and improve survival following
major abdominal surgery. Minerva Anestesiol. 2016 Oct 20. [Epub ahead of print] PMID:
27763576
4. Abbott TE, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW,
Niebrzegowska E, Rodseth RN, Devereaux PJ, Pearse RM. Preoperative heart rate and
myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of
the VISION study. Br J Anaesth 2016 Aug. 117(2):172-81. PMID: 27440628
5. Prowle JR, Kam EP, Ahmad T, Smith NC, Protopapa K, Pearse RM. Preoperative renal
dysfunction and mortality after non-cardiac surgery. Br J Surg. 2016 Sept. 103(10):131625 PMID: 27346181
6. Wijeysundera DN, Pearse RM, Shulman MA, Abbott TE, Torres E, Croal BL, Granton JT,
Thorpe KE, Grocott MP, Farrington C, Myles PS, Cuthbertson BH; METS Study
Investigators. Measurement of Exercise Tolerance before Surgery (METS) study: a
protocol for an international multicentre prospective cohort study of cardiopulmonary
exercise testing prior to major non-cardiac surgery. BMJ Open. 2016 Mar
11;6(3):e010359. PMID: 26969643
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7. Cecconi M, Hochrieser H, Chew M, Grocott M, Hoeft A, Hoste A, Jammer I, Posch M,
Metnitz P, Pelosi P, Moreno R, Pearse RM, Vincent JL, Rhodes A. Preoperative
abnormalities in serum sodium concentrations are associated with higher in-hospital
mortality in patients undergoing major surgery. European Surgical Outcomes Study
(EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine
and the European Society of Anaesthesiology. Br J Anaesth. 2016 Jan;116(1):63-9.
PMID: 26675950
8. Ozdemir BA, Sinha S, Karthikesalingam A, Poloniecki JD, Pearse RM, Grocott MP,
Thompson MM, Holt PJ. Mortality of emergency general surgical patients and
associations with hospital structures and processes. Br J Anaesth. 2016 Jan;116(1):5462. PMID: 26675949
9. Sadique Z, Harrison DA, Grieve R, Rowan KM, Pearse RM; OPTIMISE study group.
Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in highrisk patients undergoing major gastrointestinal surgery. Perioper Med (Lond). 2015.
Jan;116(1):54-62. PMID: 26674494.
10. O'Connor ME, Kirwan CJ, Pearse RM, Prowle JR. Incidence and associations of acute
kidney injury after major abdominal surgery. Intensive Care Med. 2015 April;42(4):521-30.
PMID: 26602784
11. Jawad M, Baigi A, Oldner A, Pearse RM, Rhodes A, Seeman-Lodding H, Chew MS.
Swedish surgical outcomes study (SweSOS): An observational study on 30-day and 1year mortality after surgery. Eur J Anaesthesiol. 2015 May;33(5):317-25. PMID:
26555869
12. Owen HC, Torrance HD, Jones TF, Pearse RM, Hinds CJ, Brohi K, O'Dwyer MJ.
Epigenetic regulatory pathways involving microRNAs may modulate the host immune
response following major trauma. J Trauma Acute Care Surg. 2015; 79: 766-72. PMID:
26496100
13. Longbottom ER, Torrance HD, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O'Dwyer
MJ. Features of postoperative immune suppression are reversible with Interferon
Gamma and independent of Interleukin-6 pathways. Ann Surg. 2015 Aug;264(2):370-7.
PMID: 26445474
14. Ahmad T, Beilstein CM, Aldecoa C, Moreno RP, Molnár Z, Novak-Jankovic V, Hofer CK,
Sander M, Rhodes A, Pearse RM.
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Variation in haemodynamic monitoring for major
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surgery in European nations: secondary analysis of the EuSOS dataset. Perioper Med.
2015; 4: 8. PMID: 26405521
15. Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the
association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;
102: 1314-24. PMID: 26349842
16. Gillies MA, Power GS, Harrison DA, Fleming A, Cook B, Walsh TS, Pearse RM, Rowan
KM. Regional variation in critical care provision and outcome after high-risk surgery.
Intensive Care Med. 2015; 41: 1809-16. PMID: 26202040
17. Gillies MA, Shah AS, Mullenheim JS, Tricklebank T, Owen J. Antonelli F, Strachan NL,
Mills and Pearse RM.
Perioperative myocardial injury in patients receiving cardiac
output-guided haemodynamic therapy: a substudy of the OPTIMISE Trial. British Journal
of Anaesthesia 2015; 115: 227-233. PMID: 26001837
18. van Zaane B, van Klei WA, Buhre WF; Wilton A, Bauer P, Boerma E. C, Hoeft, A, Metnitz,
P, Moreno RP, Pearse RM, Pelosi, P, Sander, M, Vallet B, Pettilä V, Vincent J-L, Rhodes
A. Non-elective surgery at night and in-hospital mortality: Prospective observational data
from the European Surgical Outcomes Study. European Journal of Anaesthesiology
2015; 32: 477-485. PMID: 26001104
19. Freund Y, Bloom B, Bokobza J, Baarir N, Laribi S, Harris T, Navarro V, Maguy B, Pearse
RM, Riou B, Hausfater P, the BISTRO investigators (2015). Predictive value of S100-B
and copeptin for outcomes following seizure: the BISTRO International Cohort Study.
PloS one 2015; 10: e0122405-e0122405. PMID: 25849778
20. Torrance HD, Brohi K, Pearse RM, Mein C A, Wozniak E, Prowle JR, Hinds C J,
O'Dwyer MJ. Association between gene expression biomarkers of immunosuppression
and blood transfusion in severely injured polytrauma patients. Ann Surg 2015; 261: 751759. PMID: 24670848
21. Torrance HDT, Vivian ME, Brohi K, Prowle JR,
Pearse RM, Owen HC, Hinds CJ,
O’Dwyer MJ. Changes in gene expression following trauma are related to the age of
transfused packed red blood cells. Journal of Trauma and Acute Care Surgery 2015; 78:
535-42. PMID: 25710424
22. MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ and Pearse RM.
Dynamic preload markers to predict fluid responsiveness during and after major
gastrointestinal surgery: An observational substudy of the OPTIMISE trial.
British Journal of Anaesthesia 2015; 114: 598-604. PMID: 25500941
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23. Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Shamir S,
Whittle J, Reyes A, Singer M, Hamilton M, Cecconi M, Pearse RM, Mallett SV, Omar RZ,
for the POM-O study group. Individualised oxygen delivery targeted haemodynamic
therapy in high-risk surgical patients: A multicentre, randomised, double-blind, controlled,
mechanistic trial. Lancet Respiratory Medicine 2015; 3: 33-41. PMID: 25523407
24. Jammer, T. Ahmad, C. Aldecoa, D. Koulenti, T. Goranović, I. Grigoras, B. Mazul-Sunko,
R. Matos, R. Moreno, G. H. Sigurdsson, P. Toft, B. Walder, A. Rhodes and R. M.
Pearse,* for the European Surgical Outcomes Study (EuSOS) group. Point prevalence of
surgical checklist use in Europe: relationship with hospital mortality. Br. J. Anaesthaesia
2015 May;114(5):801-7. PMID: 25586728
25. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM,
Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van
Iterson M, van der Voort PH, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G,
Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C,
Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D,
Sorbara C, Tijssen JG, Bakker J, Ince C; microSOAP Study Group; microSOAP Study
Group. International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients.
Crit Care Med. 2015; 43: 48-56. PMID: 25126880
26. Jammer I, Wickboldt N, Sander M, Smith A, Schultz MJ, Pelosi P, Leva B, Rhodes A,
Hoeft A, Walder B, Chew MS, Pearse RM. Standards for definitions and use of outcome
measures for clinical effectiveness research in perioperative medicine: European
Perioperative Clinical Outcome (EPCO) definitions. Eur J Anaesthesiology. 2015; 32: 88105. PMID: 25058504
27. Al-Khafaji A, Elder M, Lebovitz DJ, Murugan R, Souter M, Stuart S, Wahed AS, Keebler
B, Dils D, Mitchell S, Shutterly K, Wilkerson D, Pearse R, Kellum JA. Protocolized fluid
therapy in brain-dead donors: the multicenter randomized MOnIToR trial. Intensive Care
Med. 2015 Mar;41(3):418-26. PMID: 25583616
28. Moreno RP, Pearse R, Rhodes A; European Surgical Outcomes Study (EuSOS) Group
of the European Society of Intensive Care Medicine and European Society of
Anaesthesiology Trials Groups. American Society of Anesthesiologists Score: still useful
after 60 years? Results of the EuSOS Study. Rev Bras Ter Intensiva. 2015; 27(2):105-12.
PMID: 26340149
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29. Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S,
Whittle J, Reyes A, Singer M, Hamilton M, Cecconi M, Pearse RM, Mallett SV, Omar RZ;
for the POM-O study group.
Individualised oxygen delivery targeted haemodynamic
therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled,
mechanistic trial. Lancet Respir Med. 2014; 15: PMID: 25523407
30. MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM.
Br J Anaesth. Dynamic preload markers to predict fluid responsiveness during and after
major gastrointestinal surgery: an observational substudy of the OPTIMISE trial.
Br J Anaesth.2014; 11: aeu398. PMID: 25500941
31. Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ,
O'Dwyer MJ. Perioperative blood transfusion is associated with a gene transcription
profile characteristic of immunosuppression: a prospective cohort study.
Crit Care. 2014; 1: 18(5):541. PMID: 25270110
32. Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM.
Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant
vitamin d deficiency: an exploratory, double blind, randomised controlled trial.
PLoS One. 2014; 9(7): e99461. PMID: 25006678
33. Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP,
Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a
perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes
following major gastrointestinal surgery: a randomized clinical trial and systematic review.
JAMA. 2014; 311: 2181-90. PMID: 24842135
34. Gillies MA, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM.
Incidence of postoperative death and acute kidney injury associated with i.v. 6%
hydroxyethyl starch use: systematic review and meta-analysis. Br J Anaesth. 2014;
112(1):25-34. PMID: 24046292
35. Baron D, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno R, Pearse RM, Metnitz
P. Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery
patients. Brit J Anaesth 2014; epub. PMID: 24829444
36. Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ. Serum Creatinine
Changes Associated with Critical Illness and Detection of Persistent Renal Dysfunction
after AKI. Clin J Am Soc Nephrol. 2014; 9:1015-23. PMID: 24742481
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37. Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer
MJ. Association Between Gene Expression Biomarkers of Immunosuppression and Blood
Transfusion in Severely Injured Polytrauma Patients. Ann Surg. 2014; epub.
PMID: 24670848
38. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P,
Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G,
Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T,
Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G,
Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L,
Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ,
Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N,
Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA,
Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA,
Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S,
Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J,
Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D,
Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C,
Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V,
Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J,
Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C,
Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S,
Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N,
Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius
L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H,
Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S,
Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin
T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S,
Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong
GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai
HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los
Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J,
Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B,
Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner
D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A,
Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E,
Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T,
Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ,
Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J,
Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Ackland
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G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E,
Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P,
Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C,
Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood
J, Kalin M, Gibson D, Wildes T; on behalf of The Vascular events In noncardiac Surgery
patIents cOhort evaluatioN (VISION) Investigators. Myocardial injury after noncardiac
surgery: a large, international, prospective cohort study establishing diagnostic criteria,
characteristics, predictors, and 30-day outcomes. Anesthesiology 2014; 120: 564-78.
PMID: 24534856
39. James S, Jhanji S, Smith A, O’Brien G, Fitzgibbon M, Pearse RM Comparison of the
prognostic accuracy of scoring systems, cardiopulmonary exercise testing, and plasma
biomarkers: a single-centre observational pilot study. Brit J Anaesth 2014; 112: 491-7.
PMID: 24148323
40. Cullen M, Jhanji S, Pearse RM, Fitzgibbon M. Neutrophil gelatinase-associated lipocalin
and albuminuria as predictors of acute kidney injury in patients treated with goal-directed
haemodynamic therapy after major abdominal surgery. Ann Clin Biochem 2014; 51: 3929. PMID: 24123926
41. Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon MC. Peri-operative
troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay:
comparisons with hs-cTnT and contemporary cTnI assays. Ann Clin Biochem 2014; 51:
258-68. PMID: 24048718
42. Reynolds T, Vivian-Smith A, Jhanji S, Pearse RM. Observational study of the effects of
age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular
flow. Perioper Med 2013; 2: 7. PMID: 24472121
43. Walsh T, Boyd J, Watson D, Hope D, Lewis S, Krishan A, Forbes J, Ramsay P, Pearse
RM, Wallis C, Cairns C, Cole S, Wyncoll D, for the RELIEVE investigators. Restrictive
Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill
Patients: A Randomized Pilot Trial. Crit Care Med 2013; 41: 2354-63. PMID: 23939351
44. Bangash M, Patel N, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM.
Dopexamine can attenuate the inflammatory response and protect against organ injury in
the absence of significant effects on haemodynamics or regional microvascular flow. Crit
Care. 2013; 17: R57. PMID: 23531318
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45. Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L,
Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven day cohort study. Lancet
2012; 380: 1059-65. PMID: 22998715
46. VISION Study Investigators, Devereaux PJ, Chan M, Alonso-Coello P, Walsh M,
Berwanger O, Villar J, Wang C, Garutti R, Jacka M, Sigamani A, Srinathan S, Biccard B,
Chow C, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G,
Heels-Ansdell D, Sessler D, Thorlund K, Garg A, Mrkobrada M, Thomas S, Rodseth R,
Pearse RM, Thabane L, McQueen M, VanHelder T, Bhandari M, Bosch J, Kurz A,
Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S.
Association
between postoperative troponin levels and 30-day mortality among patients undergoing
non-cardiac surgery. JAMA 2012; 307: 2295-304. PMID: 22706835
47. Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM,
Bakker J, Ince C. Study Design of the Microcirculatory Shock Occurrence in Acutely Ill
Patients (microSOAP): an International Multicenter Observational Study of Sublingual
Microcirculatory Alterations in Intensive Care Patients. Crit Care Res Pract. 2012; 2012:
121752. PMID: 22666566
48. Young EL, Karthikesalingam A, Huddart S, Pearse RM, Hinchliffe RJ, Loftus IM,
Thompson MM, Holt PJ. A systematic review of the role of cardiopulmonary exercise
testing in vascular surgery. Eur J Vasc Endovasc Surg 2012; 44: 64-71. PMID: 22521839
49. Terblanche M, Kruger P, Gangi SD, Gearay S, Gilfeather L, Ferguson ND, Pearse RM,
Beale R, Rhodes A, Brett SJ, McAuley DF. Risk factors for acute organ failure in intensive
care unit patients who receive respiratory support in the absence of non-respiratory organ
failure: an international prospective cohort study. Crit Care 2012; 16: R61. PMID:
22512834
50. Davenport R, Manson J, De’Ath H, Platton S, Coates A, Allard S, Hart D, Pearse RM,
Pasi K, MacCallum P, Stanworth S, Brohi K. Functional definition and characterisation of
Acute Traumatic Coagulopathy. Critical Care Med 2011 Dec;39(12):2652-8. PMID:
21765358
51. Kavsak PA, Walsh M, Srinathan S, [24 authors], Pearse RM, Rodseth RN, Sessler DI,
Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier S, Devereaux PJ. High
Sensitivity Troponin T (TnT hs) concentrations in patients undergoing noncardiac surgery:
A prospective cohort study. Clin Biochem. 2011; 44:1021-4. PMID: 21640092
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52. Davenport R, Curry N, Manson J, De’Ath H, Coates A, Rourke C, Pearse RM, Stanworth
S, Brohi K. Hemostatic Effects of Fresh Frozen Plasma May be Maximal at Red Cell
Ratios of 1:2. J Trauma 2011; 70: 90-96. PMID: 21217486
53. Pearse RM, Rhodes A, Moreno R, Pelosi P, Spies C, Vallet B, Metnitz P, Bauer P,
Vincent JL. EuSOS: European Surgical Outcomes Study. Eur J Anaesthesiol 2011;
28:454-6. (protocol). PMID: 21544023
54. Martin-Loeches I, Lisboa T, Rhodes A, Moreno R, Silva E, Sprung C, Chiche J-D,
Barahona D, Villabon D, Balasini C, Pearse RM, Rello J. Use of early corticosteroid
therapy on ICU admission in patients affected by severe pandemic (H1N1) influenza A
infection. Intensive Care Med 2011; 37: 272-83. PMID: 21107529
55. Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds C, Pearse RM.
Haemodynamic optimisation improves tissue microvascular flow and oxygenation
after major surgery: A randomised controlled trial. Critical Care 2010; 14: R151.
PMID: 20698956
56. Spanos A, Jhanji S, Smith A, Harris T, Pearse RM. Early microvascular changes in
sepsis and severe sepsis. Shock 2010; 33: 387-391. PMID: 19851124
57. Maddison B, Wolff C, Jones P, Findlay G, Radermacher P, Hinds C, Pearse RM.
Comparison of three methods of extravascular lung water volume measurement in
patients after cardiac surgery. Critical Care 2009; 13: R107. PMID: 19580649
58. Jhanji S, Stirling S, Patel N, Hinds C, Pearse RM. The effect of increasing doses of
norepinephrine on tissue oxygenation and microvascular flow in patients with septic
shock. Critical Care Med 2009; 37:1961-6. PMID: 19384212
59. Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM. Microvascular flow and Tissue
oxygenation after major abdominal surgery: association with post-operative
complications. Intensive Care Med 2009; 35: 671-7. PMID: 18936911
60. Maddison B, Giudici G, Calzia E, Wolff C, Hinds C, Radermacher P, Pearse RM. Extravascular lung water volume measurement by novel lithium-thermal indicator dilution
method: Comparison of three techniques to post-mortem gravimetry. Intensive Care Med
2008; 34: 2106-11. PMID: 18607563
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61. Pearse RM, Belsey J, Cole J, Bennett ED. Effect of dopexamine infusion on mortality
following major surgery: Individual patient data meta-regression analysis of published
clinical trials. Critical Care Med 2008; 36: 1323-1329. PMID: 18379261
62. Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM. Mortality and utilisation of
critical care resources amongst high-risk surgical patients in a large NHS Trust.
Anaesthesia 2008; 63: 695-700. PMID: 18489613
63. Nourse S, Hurding A, McGinley A, Mandersloot G, Pearse RM, Association between
cardiac index and mortality in patients assessed on the ward by a nurse-led critical care
outreach team. Journal Intensive Care Soc 2008; 9: 118-123.
64. Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED. Incidence of
myocardial injury following post-operative Goal Directed Therapy. BMC Cardiovasc
Disorders 2007; 7: 10. PMID: 17371601
65. Pearse RM, Harrison D, James P, Watson D, Hinds CJ, Rhodes A, Grounds RM, Bennett
ED. Identification and characterisation of the high-risk surgical population in the United
Kingdom. Critical Care 2006; 10 R81. PMID: 16749940
66. Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED. Early goaldirected therapy after major surgery reduces complications and duration of hospital stay.
A randomised, controlled trial. Critical Care 2005; 9: R687-R693. PMID: 16356219
67.
Pearse RM, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED. Changes in
central venous saturation following major surgery and association with outcome. Critical
Care 2005; 9: R694-R699.
68. Pearse RM, Draper A, Grounds RM. Non-invasive ventilation to avoid tracheal intubation
in Guillain-Barre syndrome. Brit J Anaesthesia 2003; 91: 913-16. PMID: 14633766
69. Pearse RM, Dana E, Lanigan C, Pook J. Organisational failures in urgent and emergency
surgery. A potential peri-operative risk factor.
Anaesthesia 2001; 56: 684-9.
PMID: 11437772
70. Pearse RM, Rajakulendran Y. Pre-operative fasting and administration of regular
medications in adult patients presenting for elective surgery.
changed
practice?
European
Journal
of
Anaesthesiology
Has the new evidence
1999;
16:
565-568.
PMID: 10500948
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71. Pearse RM, Mitra AV, Heymann TD. What the SHO really does. J Royal College
Physicians 1999; 33: 553-556. PMID: 10633334
72. Lee CN, Vasilakis C, Kearney D, Pearse RM, Millard PH. An analysis of admission,
discharge and bed occupancy of stroke patients aged 65 and over in English hospitals.
Health Care Manag Sci. 1998; 1: 151-7. PMID: 10916594
73. Kelly R, Pearse RM, Bull R, Leveque JL, de Rigal J, Mortimer P. The effects of ageing on
the cutaneous microvasculature. J Am Acad Derm 1995; 33: 749-746.
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REVIEW ARTICLES
1. Torrance HD, Pearse RM, O'Dwyer MJ. Does major surgery induce immune suppression
and increase the risk of postoperative infection? Curr Opin Anaesthesiol. 2016 Jun;
29(3):376-83. PMID: 26963469
2. Vincent J-L, Pelosi P, Pearse RM, Payen D, Perel A, Hoeft A, Romagnoli S, Ranieri VM,
Ichai C, Forget P, Della Rocca G and Rhodes A. Perioperative cardiovascular monitoring
of high-risk patients: a consensus of 12. Critical Care 2015; vol. 19, Article ARTN 224.
PMID: 25953531
3. Retter A, Wyncoll D, Pearse R, Carson D, McKechnie S, Stanworth S, Allard S, Thomas
D, Walsh T; British Committee for Standards in Haematology. Guidelines on the
management of anaemia and red cell transfusion in adult critically ill patients. Br J
Haematol. 2013; 160: 445-64.
4. Ford SR, Pearse RM. Do integrated care pathways have a place in critical care? Curr
Opin Crit Care. 2012; 18(6): 683-7.
5. Pearse RM, Ackland G. Peri-operative intra-venous fluid therapy. British Medical Journal
2012; 344: e2865.
6. Bangash M, Kong M-L, Pearse RM. Inotrope and vasopressor therapy in critically ill
patients. Br J Pharm. 2012; 165: 2015-33.
7. Pearse RM, Holt P, Grocott M. Managing peri-operative risk in patients undergoing
elective non-cardiac surgery. British Medical Journal 2011; 343: d5759.
8. Rampal T, Jhanji S, Pearse RM. Using oxygen delivery targets to optimise resuscitation
in critically ill patients. Curr Opin Crit Care. 2010; 16: 244-9.
9. Sheperd S, Pearse RM. Role of central and mixed venous oxygen saturation
measurement in peri-operative care. Anesthesiology. 2009; 111: 649-56.
10. Jhanji S, Pearse RM. The use of early intervention to prevent postoperative
complications. Curr Opin Crit Care. 2009; 15: 349-54.
11. Powell-Tuck J, Gosling P, Lobo D, Allison S, Carlson G, Gore M, Lewington A, Pearse
RM, Mythen M. British Consensus Guidelines on Intravenous Fluid Therapy for Adult
Surgical Patients. Journal Intensive Care Soc 2009; 10: 13-15.
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12. Pearse RM, Morris C. Cardiac output monitoring should be used in critically ill patients:
Pro-Con debate. Journal Intensive Care Soc 2009; 10: 8-12.
13. Jhanji S, Dawson J, Pearse RM. Cardiac output monitoring: basic science and clinical
application. Anaesthesia 2008; 63: 172-181.
14. Pearse RM, Ikram K, Barry J. Equipment review: An appraisal of the LiDCOplus method
of cardiac output measurement. Critical Care 2004; 8: 190-195.
1
5
.
Pearse RM, Rhodes A, Grounds RM. How to optimise high risk surgical
patient management. Critical Care 2004; 8: 503-507.
16. Pearse RM, Rhodes A. Haemodynamic monitoring and circulatory management in
intensive care. Surgery 2004; 22: 88-93.
BOOK CHAPTERS
1. O’Dwyer M, Hinds CJ, Pearse RM. Intensive Care Medicine. In: Kumar & Clark’s Clinical
Medicine. 9th edition. Kumar P, Clark M eds. Elsevier, London 2016 (in press).
2. Cannesson M & Pearse RM eds. Perioperative hemodynamic monitoring and goal
directed therapy. Cambridge University Press, Cambridge 2014.
3. Hewson R, Pearse RM. Inotropic therapy. In: Encyclopaedia of Intensive Care Medicine.
Vincent J-L, Hall J eds. Springer, Berlin 2012.
4. Bangash M, Pearse RM. Microcirculation. In: Encyclopaedia of Intensive Care Medicine.
Vincent J-L, Hall J eds. Springer, Berlin 2012.
5. Hinds CJ, Watson JD, Pearse RM. Intensive Care Medicine. In: Kumar & Clark’s Clinical
Medicine. 8th edition. Kumar P, Clark M eds. Elsevier, London 2012.
6. Pearse RM. Intensive Care for the high-risk surgical patient. In: Critical Care; Oxford
Desktop Review. Soni N, Rhodes A, Waldman C eds. Oxford University Press, 2008.
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7. Pearse RM, Langford R. Peri-operative management of the high-risk surgical patient. In:
Bailey & Love’s A short practice of surgery. 24th edition. Williams N, Bulstrode J,
O'Connell P eds. Hodder Arnold London 2008.
8. Maddison B, Best T, Pearse RM. Extra-vascular lung water measurement. In: Yearbook
of Intensive Care and Emergency Medicine. Vincent J-L ed. Springer, Berlin 2007.
9. Pearse RM, Rhodes A. Mixed and Central Venous Oxygen Saturation. In: Yearbook of
Intensive Care and Emergency Medicine. Vincent J-L ed. Springer, Berlin 2005.
10. Mebazaa A, Cavana M, Pearse RM, Rhodes A. Acute heart failure. In: Patient centred
acute care training (PACT). European Society of Intensive Care Medicine 2005.
11. Pearse RM, Rhodes A, Grounds RM. Goal directed haemodynamic therapy in the
intensive care unit: application and mechanism of therapeutic effect. In: Yearbook of
Intensive Care and Emergency Medicine. Vincent J-L ed. Springer, Berlin 2004.
EDITORIALS
1. Gillies MA, Pearse RM. Intensive Care after High-risk Surgery: What's in a Name?
Anesthesiology. 2016 Apr;124(4):761-2. PMID: 26825150
2. Pearse RM, Wijeysundera DN. Steroids for cardiac surgery: has the story finally ended?
Lancet. 2015; 386:1215-6. PMID: 26460640
3. Pearse RM. The whole truth and nothing but the truth: the need for full reporting of
randomised trials. Perioperative medicine 2015; 4: 7. PMID: 26203354
4. Reynolds TE, Pearse RM. Cardiac troponins in sepsis: an indication for
echocardiography? Crit Care Med. 2014; 42: 975-6.
Rupert Pearse
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5. Prowle J, Pearse RM. Is it the end of the road for synthetic starches in critical illness? No
place for hydroxyethyl starch solutions in treatment of patients with sepsis. British Medical
Journal 2013; 346: f1805.
6. McGinley A, Pearse RM. A national early warning score for acutely ill patients. British
Medical Journal 2012; 345: e5310.
7. Grocott M, Pearse RM. Perioperative medicine: the future of anaesthesia? Brit J
Anaesthesia 2012; 108: 723-6.
8. MacDonald N, Pearse RM. Peri-operative haemodynamic therapy: only large trials can
resolve our uncertainty. Crit Care 2011; 15: 122.
9. Grocott M, Pearse RM. Prognostic studies of peri-operative risk: robust methodology is
needed. Brit J Anaesthesia 2010; 105: 243-5.
10. Pearse RM. Another inconvenient truth: meeting the challenges of preventing poor
surgical outcomes. Curr Opin Crit Care 2010; 16: 337-8.
11. Pearse RM. Water, taken in moderation, cannot hurt anybody. J Physiol 2010; 588:281-2.
12. Pearse RM. Extending the role of lactate measurement into the pre-hospital environment.
Crit Care 2009;13:115.
13. Pearse RM, Young D. The use of steroids to prevent post-extubation laryngeal oedema.
Lancet 2007; 369: 1060-1.
14. Pearse RM, Hinds CJ. Should we use central venous saturation to guide management in
high-risk surgical patients? Crit Care 2006; 10: 181.
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November 2016
GRANTS AWARDED (PREVIOUS FIVE YEARS)
Lead applicant
Edwards Lifesciences
£1.1 million
Association of Anaesthetists of Great Britain & Ireland
£48,598
Intersurgical Ltd
£40,000
National Institute for Health Research Professorship
£1.25 million
National Institute for Health Research HS & DR
£1.25 million
National Institute for Health Research Clinician Scientist Award
£940,000
BJA/RCoA Career Development Fellowship
£250,000
Brainscope Inc
£143,500
National Institute for Health Research Clinical Trials Fellowship
£59,000
British Journal of Anaesthesia
£49,000
Co-applicant:
NIHR-Health Technology Assessment (M Edwards; FLO-ELA trial)
£1.1 million
NIHR NIHR TCC Doctoral research fellowship (B Kahan)
£300,000
NIHR-Health Technology Assessment (T Walsh; ABLE trial)
£1.1 million
Canadian Institute for Health Research (D Wijeysundera; METS)
£650,000
GRANTS REVIEWED
I am a member fo the NIHR HTA general funding board. I regularly peer review grant
applications for the National Institute of Academic Anaesthesia, Intensive Care
Society, European Society of Intensive Care Medicine and for high level funding
organisations including the Wellcome Trust, Medical Research Council, NIHR-RfPB,
NIHR-HTA, University Grants Committee of Hong Kong, and the Canadian Institute
for Health Research.
Date: 29th November 2016
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