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1. Which row in the table describes the first stage of cellular respiration? Substrate Location Product Product A. pyruvate mitochondria oxygen water B. pyruvate cytoplasm carbon dioxide ATP C. glucose mitochondria pyruvate water D. glucose cytoplasm pyruvate ATP (Total 1 mark) 1 2. The diagram below shows the three stages of glycolysis. Which processes are indicated by I, II and III? 6-carbon glucose I 6-carbon glucose phosphate II 3-carbon sugar phosphate 3-carbon sugar phosphate III 3-carbon pyruvate 3-carbon pyruvate I II III A. Lysis Phosphorylation Oxidation and ATP formation B. Oxidation and ATP formation Phosphorylation Lysis C. Phosphorylation Lysis Oxidation and ATP formation D. Phosphorylation Oxidation and ATP Lysis 2 formation (Total 1 mark) 3. Humans can respire aerobically and anaerobically. Which are products of both aerobic cell respiration and anaerobic cell respiration in humans? A. Pyruvate and ATP B. Pyruvate and lactate C. ATP and carbon dioxide D. Lactate and carbon dioxide (Total 1 mark) 4. What is the net production of ATP, per molecule of glucose during the fermentation of glucose to lactate? A. 36 molecules B. 4 molecules C. 2 molecules D. None (Total 1 mark) 5. Where in eukaryotic cells is glucose broken into pyruvate, to release energy for use in the cell? A. Chloroplast B. Cytoplasm C. Mitochondrion D. Nucleus (Total 1 mark) 3 6. What is the correct sequence of chemicals produced in the anaerobic respiration pathway? A. Lactate → pyruvate → ethanol B. Ethanol → pyruvate → glucose C. Glucose → lactate → pyruvate D. Glucose → pyruvate → lactate (Total 1 mark) 7. What is the key function of acetyl CoA in cellular respiration? A. Involved in carbohydrate and fatty acid metabolism B. Used in anaerobic respiration to oxidize pyruvate C. Introduces amino acids into the Krebs cycle D. Used as a hydrogen carrier in the link reaction (Total 1 mark) 8. Which of the following features is/are present in mitochondria but not in chloroplasts? I. DNA and ribosomes II. Outer and inner membranes III. Cristae A. I only B. II only C. III only D. I and III only (Total 1 mark) 4 9. What are the end products of aerobic cell respiration? A. Carbon dioxide and ethanol B. Lactate and ATP C. Water, ATP and oxygen D. Water, carbon dioxide and ATP (Total 1 mark) 10. Of the following products, which is produced by both anaerobic respiration and aerobic respiration in humans? I. Pyruvate II. ATP III. Lactate A. I only B. I and II only C. I, II and III D. II and III only (Total 1 mark) 11. Within the mitochondria, what compound is produced through oxidation of fatty acids? A. Acetyl-CoA B. Acetylcholine C. Oxaloacetate D. Pyruvate (Total 1 mark) 5 12. Which combination of changes describes biological oxidation? Electrons Oxygen Hydrogen A. loss gain loss B. loss loss gain C. gain loss gain D. gain gain loss (Total 1 mark) 13. During which process are oxygen molecules directly involved during cellular respiration? A. Glycolysis B. Krebs cycle C. Oxidation of pyruvate to acetyl CoA D. Accepting electrons at the end of the electron transport chain (Total 1 mark) 14. What is the “link reaction” in eukaryotic respiration? A. Pyruvate joining with coenzyme A to produce CO2 and NADH + H+ B. Oxidation of NADH to yield electrons and protons C. Acetyl coenzyme A combining or joining with a C4 compound to give C6 + coenzyme A D. Passage of acetyl coenzyme A through the mitochondrial membrane (Total 1 mark) 6 15. The average surface area for the inner membranes of mitochondria in a epithelial cell is 40 m2 g–1. The surface area of the inner membrane of mitochondria from heart muscle cells is over 200 m2 g–1. What is the reason for the large surface area of the inner membranes of the mitochondria in the heart muscle cells? A. They contain enzymes to hydrolyse ADP and inorganic phosphate to ATP. B. They contain enzymes to oxidize ADP and inorganic phosphate to ATP. C. They contain enzymes to reduce ADP and inorganic phosphate to ATP. D. They contain enzymes to condense ADP and inorganic phosphate to ATP. (Total 1 mark) 16. Which of the following reactions is an oxidation reaction? A. Pyruvate Acetate + CO2 B. FAD + 2H+ + 2e– FADH2 C. Ribulose bisphosphate + CO2 2 Phosphoglycerate D. NADP+ + 2H+ + 2e– NADPH + H+ (Total 1 mark) 17. Which is not a product of the Krebs cycle? A. CO2 B. NADH + H+ C. Pyruvate D. ATP (Total 1 mark) 7 18. Which of the following produce ATP in mitochondria? A. The movement of protons from the matrix to the intermembrane space B. The movement of protons from the intermembrane space to the cytoplasm C. The splitting of water molecules and the movement of electrons to oxygen D. The movement of protons from the intermembrane space to the matrix (1) 19. Aerobic respiration involves conversion of glucose into pyruvate and conversion of pyruvate into carbon dioxide and water. Where do these processes occur in a eukaryotic cell? Where glucose is broken down into pyruvate Where pyruvate is broken down into carbon dioxide and water A. Cytoplasm Cytoplasm B. Cytoplasm Mitochondrion C. Mitochondrion Cytoplasm D. Mitochondrion Mitochondrion (Total 1 mark) 8 20. How many molecules of acetyl CoA (ethanoyl CoA) does the oxidation of the fatty acid stearic acid produce? CH 3 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 Stearic acid CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 COOH A. 2 B. 6 C. 9 D. 18 (1) 9 21. What happens during muscle contraction? A. Both actin and myosin filaments shorten. B. Na+ ions are taken up by the sarcoplasmic reticulum. C. The actin and myosin filaments slide over each other. D. Cross bridges remain attached to the filaments. (Total 1 mark) 22. How many ATP molecules (net yield) are produced per molecule of glucose as a direct result of glycolysis? A. 2 B. 4 C. 10 D. 38 (Total 1 mark) 23. What accumulates in the inter-membrane space of the mitochondrion during electron transport? A. ATP B. Electrons C. Protons (hydrogen ions) D. Oxygen (Total 1 mark) 10 24. What is the sequence of stages during the conversion of glucose into pyruvate in glycolysis? A. Lysis phosphorylation of sugar B. Lysis oxidation C. Phosphorylation of sugar lysis D. Phosphorylation of sugar oxidation oxidation phosphorylation of sugar oxidation lysis (Total 1 mark) 25. Which way do the protons flow when ATP is synthesized in mitochondria? A. From the inner matrix to the intermembrane space B. From the intermembrane space to the inner matrix C. From the intermembrane space to the cytoplasm D. From the cytoplasm to the intermembrane space (Total 1 mark) 11