Download Mutual Information based Medical Image Registration - U

ADC Calculations
Lars Ewell
Radiation Oncology University of Arizona Medical Center
2/8/08
1
ADC Across Slices
• ADC needed for entire lesion, NOT for single
contour.
• Area/Volume needs to be accounted for.
• Slice spacing also can affect values.
2
Imaging Protocol: First Patient
• Given standard treatment for GBM(resected):
2Gy/Fx  23 Fx (46Gy) + 2Gy/Fx  17 Fx (14Gy). Tx
finished on 2/19/07. Total of 60Gy. This Tx alone
would have enabled enrollment in protocol.
• Prescribed additional dose of 15 Gy to same area
via Stereotactic Radio Surgery (SRS). Patient at
high risk for radiation necrosis. Enrolled/scanned
on 3/23/07. Scan time 1 hr 13min.
• Treated with 15 Gy additional radiation on
3/28/07.
3
MRI Scans Used for Contouring: T2 FLAIR (?)
1
4
2
5
3
6
4
MRI Scans Used for ADC Calculation – diffrad, b=0
1
4
2
5
3
6
5
Comparison of Scans
• T2 FLAIR/Brainscan  Vlesion=9.14cc
• b=0 Protocol Scan  Slice Thickness = 5mm
• b=0 Protocol Scan  Slice Spacing = 7mm
6