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> Research Report St George and Sutherland Hospitals 2012 » 2013 > introductions Professor John Edmonds Conjoint Professor, UNSW Chair of the St George and Sutherland Medical Research Foundation The Research Report of the St George and Sutherland Hospitals, currently published every second year, is an important record of our clinical and research staff and some traditional indicators by which institutions’ research status is judged: projects undertaken, grants awarded, publications and presentations. There are encouraging pointers, great and small, that government and society are increasingly recognising the importance of medical research: McKeon’s Strategic Review of Health and Medical Research; a federal commitment to a 20 billion dollar medical research fund; the choice of Suzanne Corey (former Director of WEHI) as the 2014 Boyer Lecturer; even a recent Q & A session devoted to Science & Australia. As society looks to its great academic medical centres for research-driven guidance, it becomes ever more important that St George and Sutherland Hospitals match the excellence of their clinical service and teaching with a comparable level of eminence in research endeavour and success. The St George and Sutherland Medical Research Foundation is committed to helping the hospitals’ academics in that project. The Research Reports provide a useful audit of our joint progress. Professor Peter Gonski Head, Sutherland Teaching Unit St George Clinical School Although Sutherland Hospital is well known as a provider of major clinical service to the South Eastern Sydney Local Health District, it also provides a major teaching resource to medical, nursing and allied health students. Research is now becoming important in its activities. On behalf of Sutherland, I am grateful that the St George and Sutherland Medical Research Foundation has included us in their activities and also providing research funds. With the close relationships between the hospital, community, Universities and Foundation, which have already been secured, I can only see the research interest increase in the future. I do think that our significant clinical load allows us to be leaders in clinical research and assure that our research will directly influence patient care and lives. It is wonderful to have our research celebrated in this report. Professor Ritin Fernandez Professor of Nursing Research and Innovation is vital to the provision of quality healthcare for our patients. At St George Hospitals clinician and scientists undertake the full spectrum of basic biomedical, clinical and health services research. There has been a remarkable progress in research outputs and outcomes at St George Hospital and this report high lights the unique and influential research that is being conducted by our world class researchers. The report also demonstrates the commitment of researchers and scientists not only towards evidence synthesis but also in translating and implementing the evidence in clinical practice. I would like to acknowledge the role and contribution of the broader hospital community, our patients, the many volunteers, our collaborators and supporters, particularly the St George and Sutherland Medical Research Foundation without whom research here would not be possible. The research achievements are very encouraging, but more importantly they form the foundation for future research endeavours as well as provide inspiration and motivation as we move forward. Professor Michael Grimm Clinical Associate Dean St George Clinical School, UNSW Research in our hospitals fundamentally supports the excellence in clinical care for which we all strive. If anything, this will become even more important in coming years. This important report demonstrates the extraordinary breadth and impressive depth of research activities undertaken at St George and Sutherland Hospitals, and I hope it serves to announce those achievements loudly and emphatically. The composing of a document such as this always comes as a surprise: surprise at the breadth and volume of research carried out by hospital and university staff and students, from most senior to undergraduate levels. It’s a testament to the enormous amount of hard work that goes into making our hospitals vital and inquiring places, as well as places of healing. I commend this report to all members of our hospital communities. > Contents Medicine And Critical Care 5 Mental Health 109 Cardiology 6 Dermatology 8 Mental Health Academic Unit, School of Psychiatry 110 Women’s and Children’s Health 115 Emergency – St George Hospital 15 Emergency – The Sutherland Hospital 18 Endocrinology 19 Urogynaecology 116 Gastroenterology and Hepatology 22 Women’s Health 119 Infectious Disease, Immunology and Sexual Healh 27 Nursing and Midwifery 127 Intensive Care – St George Hospital 31 Nuclear Medicine 41 Centre for Research in Nursing and Health 128 Renal Medicine 42 Respiratory and Sleep Medicine 47 136 Rheumatology 49 South Eastern Sydney Laboratory Services Anatomical Pathology 137 Aged and Extended Care 139 Cancer Services 52 Haematology 53 Medical Oncology 61 Aged Care St George Hospital 140 Palliative Care 69 Rehabilitation Medicine 141 Radiation Oncology 79 Southcare The Sutherland Hospital 142 Surgery, Perioperative And Anaesthetic Services 82 Allied Health 143 Anaesthesia 83 Nutrition and Dietetics 144 Cardiothoracic Surgery 85 Occupational Therapy 146 Liver and Periotonectomy Surgery 90 Physiotherapy 147 Orthopaedic Surgery 96 Speech Pathology 148 Erratum 151 Trauma 104 Vascular Surgery 108 MEDICINE AND CRITICAL CARE Cardiology > 6 Renal Medicine > 42 Dermatology > 8 Respiratory Medicine > 47 Emergency – St George Hospital > 15 Rheumatology > 49 Emergency – Sutherland Hospital > 18 Endocrinology > 19 Gastroenterology and Hepatology > 22 Infectious Disease, Immunology and Sexual Health > 27 Intensive Care – St George Hospital > 31 Nuclear Medicine > 41 > Department of Cardiology Head of Department Dr Mark Sader MBBS(Hons) PhD Senior Medical - Staff Specialists Dr David Ramsay Dr David Rees Dr Andrew Hopkins Dr Maurits Binnekamp Dr Ananth Prasan Dr George Youssef Dr James Weaver BSc Med MBBS(Hons) PhD Dr Queenie Lo Dr Victar Hsieh Research Staff Deborah Vrachas – CNS Glenn Paull - CNC Research Projects in Progress A bone marrow-derived Stro3 mesenchymal precursor cells (MPC) in the treatment of patients with ST-elevation myocardial infarction, Dr. Ananth Prasan. A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When AMG 145 is Used in Combination With Statin Therapy In Patients with Clinically Evident Cardiovascular Disease, Dr. Ananth Prasan. Prevention of contrast-induced acute kidney injury In people undergoing angiogram, Dr. Ananth Prasan. TIGRIS Study data collection 1-3yr post MI patients, Dr Mark Sader Study to evaluate Cardiovascular Outcomes Following Treatment with study drug in Addition to Standard of Care in Subjects with Type 2 DM and ACS, Dr. Ananth Prasan. Thromectomy VS PCI alone in STEMI patients, Dr James Weaver. The Advisa MRI System study is a prospective, randomised controlled, non-blinded, multi centre worldwide investigational study, Dr Andrew Hopkins. To confirm safety and effectiveness of the Model 5076 6 Lead in the clinical MRI (Magnetic Resonance Imaging) environment, Dr Andrew Hopkins. A Multicentre, Randomised, Double blind, PlaceboControlled Study to Evaluate the Safety and Efficiency of study drug in Addition to Standard of Care in subjects with Acute Coronary Syndrome. Thrombin Receptor Antagonist in Acute Coronary Syndrome, Dr Ananth Prasan. A Phase 3, Randomised, Double-Blind, Evaluation of the Safety and Efficiency of study drug In Subjects with a recent ACS, Dr. Ananth Prasan. Trial Evaluating CV Outcomes with study drug in patients with Type 2 Diabetes, Dr. Maurits Binnekamp. A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with elevated hsCRP, Dr George Youssef. Original Peer-Reviewed Publications Rayner BS, Figtree GA, Sabaretnam T, Shang P, Mazhar J, Weaver JC, Lay WN, Witting PK, Hunyor SN, Grieve SM, Khachigian LM, Bhindi R. Selective Inhibition of the Master Regulator Transcription Factor Egr-1 Using Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association. 2013; 2 (4):e000023. PMID 23902638. Sorensen R, Paull G, Magaan L, Davis JM (2013). Managing between the agendas - implementing health care reform policy in an acute care hospital. Journal of Health Organization and Management; 27 (6) 698-713. Presentations at Scientific Meetings and Conferences 2012 International Sorensen R, Paull G, Magaan L, Davis JM. Is poor quality of care built into the system? Evidence from a study on communication among teams treating people dying in hospital wards. 8th International Organisational Behaviour in Healthcare Conference - Patient-centred healthcare teams: achieving collaboration, communication and care. Dublin, Ireland. 2012 National Paull G, Gallagher R, Horvath R, Chen D. Discrimination and high sensitivity cardiac troponin: the relationship between clinical presentation, clinical request and discharge diagnosis. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand, Brisbane. Chandrasekhar J, Paull G, Youssef G, Weaver J, Rees D. Single Centre Clinical Experience and Discharge planning using high sensitivity troponin T post Elective PCI. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand, Brisbane. Davis S, Paull G, Vuong N, Connolly B, Ang E. ICD’s and PTSD: a shocking story - from crisis to recovery. Australian Cardiovascular Health and Rehabilitation Association Annual Conference, Brisbane. Paull G. Chronic Disease Self-management: Multilingual Audiovisual Resources for People with Ischaemic Heart Disease and Chronic Heart Failure. Australasian Cardiovascular Nursing College Annual Scientific Meeting, Sydney. 2013 National Arndt M, Paull G. Living Well with Heart Failure: a role for Occupational Therapy in the management of chronic heart failure. Australian Cardiovascular Health & Rehabilitation Association Annual Scientific Meeting – Melbourne. > Department of Dermatology Head of Department 2012-Jan 2013 Julie Dandenooy, Medical resident, Antwerp University, Belgium, Oct-Nov 2012; now Dermatology registrar *Dedee F Murrell MA(Cambridge) BMBCh (Oxford) FAAD (USA) MD (UNSW) FACD Conjoint Professor, Faculty of Medicine UNSW Research Staff/Students Supervised Senior Medical Senior Visiting Medical Officers *Anthony J Cronin MBBS (Syd) PhD (Cambridge) FACD *Mei-Heng Tan MBBS (Syd) FAAD (USA) Lizbeth Ruth A Intong MD FPDS Post dermatology research fellow; now FACD Sabbaticals M.Tariq Khan PhD (London) M Pod (UK), from Great Ormond St Hospital, Visiting Fellow, UNSW 2011-14 Research Fellows Dr Clarisse G Mendoza (Honorary VMO and Research Fellow Mae Ramirez MD FBDS (Honorary VMO and Research Fellow Jaehwan Kim MD PhD (Honorary VMO and Research Fellow Joni Lazo Dizon MD FPDS (Honorary VMO and Research Fellow Junior Benjamin S Daniel B.Com, MBBS- Predermatology research fellow-2011-12 Research Students Wenfei Yan MD China- completed PhD (UNSW) 2012; post Doc 2013; Supriya Venugopal MBBS – p/t PhD student; Heather Cohn, MD PhD Postdoc on America Australia Association grant Clement Loh (Honours research student)- High distinction Nursing Research CNC for Epidermolysis Bullosa Lesley M Rhodes RN Jackie Cochrane RN Charmaine Peras RN Lesley M Rhodes RN Margaret Norris RN Independent Learning Project Students *Unaccredited dermatology registrars: Bonnie Fergie MBBS (UWA) 2012 Robert George MBBS (Otago) M Surg (U Syd) 2013 Jessica Davey Anh Tran (distinction) Charles Wang *Funded by St George Hospital; rest from external sources. Visiting Dermatologists to St George/Premier Specialists Research Grants William Hoang, Wake Forest University, NC, USA, 2012 (WDS grant) Nancy Todes Taylor, San Francisco, Kaiser Permanente 2012 NHMRC Project Grant: Investigation of flightless-1 in epidermolysis bullosa. Allison Cowin, Ruth Arkell, Dedee Murrell. $517,500, 2009-12. Junior Medical Visiting Dermatology Mentee Observers Michele Ramien, Derm Registrar, Univ of Ottawa, Jan-Feb 2012 Sang Hee Lee, Derm Registrar, Yonsei University College of Medicine, Seoul, Korea, May 2012 Herm Maartens, Derm Registrar, Masstricht University, Oct 8 Grant from DebRA Australia, Dedee Murrell. $12,000, 2012/2013. Grant for Biologics Clinic, Abbott Pharmaceuticals, Dedee Murrell , $15,000, 2012/2013. Donation for EB Research from Caroline Quinn Trust Fund, Dedee Murrell $25,000, 2012/2013. Research Projects in Progress Responsiveness of a quality of life instrument for autoimmune blistering diseases, the ABQOL we developed; Dedee Murrell, Renette Ang, Melanie Doria, Cathy Zhao. International validation of the QOLEB, the qualify of life measure we developed and published for Australian patients with EB; Dedee Murrell and various international investigators. Outcomes of pregnancies in EB; Murrell DF, Intong LRA, Choi DS, Rhodes LM, Walton J, Chapman M. Role of flightless-1 in EB and EBA; Kopecki Z, Murrell DF, Cowin, A. AIBD Registry; Dermawan A, Intong LRA, Murrell DF. Epidemiology of Anaemia in EB; Hwang S, Daniel BF, Murrell DF. Epidemiology of renal impairment in EB; Murrell DF. Original Peer-Reviewed Publications Intong LRA, Murrell DF: Inherited EB: New diagnostic criteria and classification. Clin Dermatol. 2012 JanFeb;30(1):70-7. doi: 10.1016. Sarig O, Bercovici S, Zoller L, Goldberg I, Indelman M, Nahum S, Israeli S, Sagiv N, Martinez de Morentin H, Katz O, Baum S, Barzilai A, Trau H, Murrell DF, Bergman R, Hertl M, Rosenberg S, Nöthen MM, Skorecki K, Schmidt E, Zillikens D, Darvasi A, Geiger D, Rosset S, Ibrahim SM, Sprecher E. Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris. J Invest Dermatol. 2012 Mar 22. doi: 10.1038/jid.2012.46 Venugopal SS, Murrell DF. Diagnosis and clinical features of pemphigus vulgaris. Immunol Allergy Clin North Am. 2012 May;32(2):233-43. Frew JW, Murrell DF. Corticosteroid use in AIBD. Immunol Allergy Clin North Am. 2012 May;32(2):283-94. Chee SN, Murrell DF.Use of Intravenous immunoglobulin in autoimmune blistering diseases. Immunol Allergy Clin North Am. 2012 May;32(2):323-30. Daniel BS, Murrell DF, Joly P. Rituximab and its use in autoimmune blistering disorders. Immunol Allergy Clin North Am. 2012 May;32(2):331-7. Murrell DF Autoimmune diseases of the skin. Immunol Allergy Clin North Am. 2012 May;32(2):xiii-xiv. Ng YZ, Pourreyron C, Salas-Alanis JC, Dayal JH, CepedaValdes R, Yan W, Wright S, Chen M, Fine JD, Hogg FJ, McGrath JA, Murrell DF, Leigh IM, Lane EB, South AP. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa. Cancer Res. Jul 15;72(14):3522-34, 2012. Wriston CC, Rubin AI, Martin LK, Kossard S, Murrell DF. Plaque like cutaneous mucinosis. Am J Dermatopathol. 2012 Jun;34(4):e50-4. Daniel BS, Murrell DF. Intravenous immunoglobulin: recent advances in the treatment of autoimmune bullous diseases. J Ital Dermatol Venereol. 2012 Jun;147(3):25967. Hwang S, Kim MH, Kemble Welch A, Hanley MC, Murrell DF. Volunteering at an adventure camp for epidermolysis bullosa. Med J Aust. 2012 2012 Jul 5;197(1):54. Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H. Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting. Allergy. Sep;67(9):1111-7, 2012. Daniel BS, Skowronski G, Myburgh J, Hersch M, Murrell DF. Concurrent Management of Toxic Epidermal Necrolysis with Thermal Water Spray and non-stick dressings. Acta Dermatol Croat; 20(3):210-212,2012. Sebaratnam DF, Venugopal SS, Frew JW, McMillan JR, Finkelstein ER, Martin LK, Murrell DF. Diffuse melanosis cutis: a systematic review of the literature. J Am Acad Dermatol. 9 2012 Dec 5. doi:pii: S0190-9622(12)00901-2. 10.1016/j. jaad.2012.08.018.1. Kopecki Z, Ruzehaji N, Turner C, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ. Topically applied Flightless I neutralising antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita. J Invest Dermatol 6th Dec 2012 doi:10.1038/ jid.2012.457. Chow HT,Tran K, Millar E, Lynch J, Murrell DF. Diverse Presentations of Carcinoma Erysipelatoides to a teaching hospital in Australia. Case Reports in Dermatological Medicine. 2012;2012:134938. doi: 10.1155/2012/134938. Epub Dec 23. Kim MH, Li M, Intong LRA,Tran K, Melbourne W, Marucci D, Bucci J, de Souza P, Mallesara G, Murrell DF: Use of cetuximab as an adjuvant agent to radiotherapy and surgery in Recessive Dystrophic Epidermolysis Bullosa with Squamous Cell Carcinoma. Br J Dermatol 2013 Feb 12. doi: 10.1111/bjd.12272. Ramirez M, Murrell DF, Fine JD. Management of Epidermolysis Bullosa Exp Opin Orph Drugs. Apr 2013, Vol. 1, No. 4, Pages 279-293. Daniel BS, Murrell DF, Borradori L. Management of Bullous Pemphigoid. Exp Opin Orph Drugs. May 2013, Vol. 1, No. 5, Pages 405-412. Tong PL, Qin J, Cooper CL, Lowe PM, Murrell DF, Kossard S, Ng LG, Roediger B, Weninger W, Haass NK. A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy. Br J Dermatol. 2013 May 11. doi: 10.1111/bjd.12430. Daniel BS, Murrell DF. Complete resolution of chronic multiple verruca vulgaris treated with quadrivalent human papillomavirus vaccine. JAMA Dermatol. 2013 Mar;149(3):370-2. doi: 10.1001/jamadermatol.2013.1463. Kim J, Loh CH, Murrell DF. Epidermolysis bullosa pruriginosa triggered by scabies infestation J Dermatol. 2013 May 10. doi: 10.1111/1346-8138.12167. Murrell DF: The pitfalls of skin biopsies for the diagnosis of epidermolysis bullosa Pediatr Dermatol. 2013 MarApr;30(2):273-5. doi: 10.1111/pde.12095 Sebaratnam DF, Hanna AM, Chee SN, Frew JW, Venugopal SS, Daniel BS, Martin LK, Rhodes LM, Tan JC, Wang CQ, Welsh B, Nijsten T, Murrell DF. Development of a Quality-of-Life Instrument for Autoimmune Bullous Disease: The Autoimmune Bullous Disease Quality of Life Questionnaire.JAMA Dermatol. JAMA Dermatol. 2013 Oct;149(10):1186-91. Frew JW, Cepeda-Valdes R, Fortuna G, Murrell DF, Salas-Alanis J: Measuring Quality of Life in Epidermolysis 10 Bullosa in Mexico: Cross Cultural Validation of the Hispanic Version of the Quality of Life in Epidermolysis Bullosa Questionnaire. J Am Acad Dermatol 2013 69(4) 652-63. Venugopal SS, Yan W, Frew JW, Cohn HI,Rhodes LM, Tran K, Melbourne W, Nelson JA, Sturm M, Fogarty J, Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell DF. A phase II randomized vehicle controlled trial of intradermal allogeneic fibroblast therapy for recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol Sep 24 2013. doi:pii: S0190-9622(13)00864-5. 10.1016/j. jaad.2013.08.014 . Tjokrowidjaja A, Daniel BS, Frew JW, Sebaratnam DF, Hanna AM, Chee SN, Dermawan A, Wang CQ, Lim C, Venugopal SS, Rhodes LM, Welsh B, Nijsten T, Murrell DF. The development and validation of the TABQOL, a tool to measure the quality of life impacts of treatments used in patients with autoimmune blistering disease. Br J Dermatol published online 31 Oct 2013 DOI: 10.1111/ bjd.12623 with accompanying editorial by Andrew Finlay mentioning its significance. Loh CH, Kim J, Su JC, Daniel BS, Venugopal SS, Rhodes LM, Intong LRA, Law MG and Murrell DF. Development, Reliability and Validity of a novel Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI). J Am Acad Dermatol 2014 Jan;70(1):89-97. Brennan F, Murrell DF: Report from the Inaugural Pruritus Symposium, Sydney, Australia, 10th August 2013. Acta Derm Venereol. 2013 Oct 24. doi: 10.2340/000155551732. Sebaratnam DF, Venugopal SS, Murrell DF: Development of an excel spreadsheet to document activity in autoimmune bullous diseases. Acta Dermatovenerol Croat. 2013 Oct;21(3):207-8. Dayal J, Cole C, Pourreyron C, Watt S, Lim Y, Salas-Alanis J, Murrell DF, McGrath J, Steiger B, Jahoda C, Leigh I, and South AP. Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes. J Cell Sci (Dec 2013 e pub). Murrell DF, Amagai M, Werth VP: Why bother with scoring systems for blistering diseases in practice and which one should you use? Invited editorial. JAMA Dermatol 2014 Jan 15. doi: 10.1001/jamadermatol.2013.8179. Yuen QY, Frew JW, Veerman K, Van den Heuvel ER, Murrell DF, Jonkman MF: Health related quality of life in epidermolysis bullosa: validation of the Dutch QOLEB Questionnaire and assessment in the Dutch population. Acta Derm Venereol 2013 Dec 12. doi: 10.2340/0001555517582013. Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ: Flightless I overexpression impairs skin barrier development, function and recovery post skin blistering. J Pathol Dec 28, 2013 e pub. DOI 10.1002/path 4323. Other published material Up to date: DF Murrell invited author for 4 chapters, 2012, with biannual updates: Murrell, DF. ICD-11 – section on definitions and descriptions of Epidermolysis Bullosa 2012 Murrell, DF, Textbook: Blistering Diseases. Springer Verlag. In process, 2013. Murrell DF, Cases in Blistering Diseases. Elsevier, book, 2013. Daniel BS, Murrell DF. Epidermolysis Bullosa. In: Clinical Genomics: Practical Applications in Adult Patient Care. McGraw Hill and American College of Physicians, 2013, chapter 110. Sebaratnam DF, McMillan JR, Werth V, Murrell DF: Quality of life in patients with bullous dermatoses. Clinics in Derm Jan;30(1):103-7. doi: 10.1016/j.clindermatol.2011.03.016., 2012. Daniel BS, Hertl M, Werth VP, Eming R, Murrell DF: Severity Score Indexes for blistering diseases. t, Jan;30(1):108-13, 2012 doi: .1016/j. clindermatol.2011.03.017. Kim MH, Intong LRA, Murrell DF: Epidermolysis bullosa and squamous cell carcinoma. In: Squamous Cell Carcinoma, Editor: Daniel V. Mortensen. Nova Publishers, Ch 5:107-122, 2012. ISBN: 978-1-61209-929-3. Fergie BF, Intong LRA, Murrell DF: Management strategies for epidermolysis bullosa acquisita. In Update in dermatologic drug therapy, edited by Jasna Lipozencic. Published by the Academy of Medical Sciences of Croatia, Zagreb, 2012. ISBN 978-953-6868-39-1. Chapter 21, pp 245-253. Frew JW, Murrell DF: An update on the use of corticosteroids in autoimmune blistering diseases. In Update in dermatologic drug therapy, edited by Jasna Lipozencic. Published by the Academy of Medical Sciences of Croatia, Zagreb, 2012. ISBN 978-953-6868-391. Chapter 22, pp 254-268. Loh CH, Kim J, Murrell DF: Urticaria. In: Australian Doctor How to Treat Yearbook 2013, pp 213-218. Editor: S. Liang. Publisher: Craft Print, Singapore. Presentations at Scientific Meetings and Conferences 2012 Professor D. Murrell American Academy of Dermatology, San Diego, March 2012, Autoimmunity forum – what’s new in autoimmune bullous diseases - invited lecture Stanford University – Epithelial Biology Marinkovich Lab, March 2012, Allogeneic cultured fibroblast therapy for recessive dystrophic epidermolysis bullosa - invited lecture American Academy of Dermatology, Boston, MA, August 2012, Forum on AIBD – Complex cases - invited lecture NSW Dermatology Nurses Association, August 2012, Management of autoimmune blistering diseases- invited lecture GP education evening, St George Area, August 2012. Skin manifestations of systemic disease. 80 GPs. Sponsored by Stiefel/GSK - invited lecture Continental Congress of Dermatology, Durban, South Africa, Oct 2012, 3 invited lectures Management of lupus in women – Maria Duran sympsosium - Epidermolysis Bullosa – what’s new? Pemphigoid – what’s new? American Academy of Dermatology, San Diego, CA, March 2012 Chair, Forum on Management of Epidermolysis Bullosa Speaker - Pathogenesis of squamous cell carcinoma in EB Speaker - What’s new in autoimmune blistering diseases. Co-chair, First Inernationall Consensus meeting on EBA 3rd World Congress of Dermoscopy – Brisbane, QLD, May 2012. Chair, Women’s Dermatologic Society networking reception. Australasian College of Dermatologists Meeting, Brisbane, QLD, May 2012 Plenary speaker – ERIVANCE phase II trial for advanced BCC Speaker - Consensus definitions and scoring for Bullous Pemphigoid. American Academy of Dermatology Summer Meeting, Boston, Aug 15-19, 2012 Chair- Forum on Difficult cases in bullous diseases Continental Congress of the International Society of Dermatology, Durban, S. Africa, Oct 25-29, 2012. Chair, Blistering Diseases Symposium Speaker, Paediatric Dermatology – what’s new in EB therapies Speaker, Maria Duran Symposium- Management of lupus in women and children. 11 Grading of Registrar presentations & presentation of awards at opening ceremony treatment of Pemphigus, Shiraz University Hospital- 17th June. Epidermolysis triennial research conference (invitation only); Marbella, Spain, Nov 4-7, 2012. Invited speaker – scoring systems for EB 3rd Munich International Summer Academy of Practical Dermatology, July 2013 Invited speaker – diagnosis and management of lupus (plenary) WDS speaker - hedgehog inhibitors for advanced and metastatic BCC. Australasian Society for Dermatological Research, Sydney, NSW May 22-24, 2012 Murrell DF, Convenor of the ASDR conference Venugopal S, Yan WF, Frew JW, Murrell DF: Randomized controlled trial of cell therapy for RDEB. Venugopal SS, Rhodes LM, Welsh B, Nijsten T, Murrell DF: Validation of a the psychometric properties of a quality of life measure specific to autoimmune bullous disease. Kim MH, Li M, Intong RA, Tran K, Melbourne W, Marucci D, Inder S, Bucci J, De Souza P, Mallesara G, Murrell DF: Use of cetuximab as an adjuvant agent to radiotherapy and surgery in Recessive Dystrophic Epidermolysis Bullosa with Squamous Cell Carcinoma. 2013 Professor D. Murrell American Academy of Dermatology, Miami, USA, March 2013 Chair, EB Management Forum; speaker on EB and squamous cell carcinoma Speaker - Biologics beyond psoriasis forum – rituximab Speaker – cell therapy for epidermolysis bullosa Speaker – what’s new in epidermolysis bullosa. Israeli Dermatology Society, Tel Aviv, April 24-26, 2013 Invited keynote Speaker –plenary lecture- Evidence based treatment of AIBD. Bullous Disease Research meeting, Lubeck, Germany: Speaker - Scoring systems for AIBD; Speaker - Consensus conference on EBA. World Congress of Paediatric Dermatology, Madrid, Spain, Sept 25-29, 2013 Invited Chair – blistering diseases in children Speaker – neonatal autoimmune blistering disorders Poster- validation of QOLEB in Brazilian Portuguese & of EBDASI. European Academy of Dermatovenereology, Istanbul, Turkey, Oct -4-7, 2013 Chair- autoimmune blistering diseases Speaker – Collagen VII spectrum disorders Speaker - Validation of EBDASI scoring system Co-Chair- Women’s Dermatologic Society Rose Parade of Cases World Congress – International Society of Dermatology, New Delhi, India, Dec 2013 Co-Chair & Speaker, Autoimmunity Symposium Invited Speaker, What’s New in treatment of genetic skin diseases Member of the Scientific Committee Co-Chair, Women’s Dermatologic Society Rose Parade of Cases R. N. T Medical college, Udaipur,Rajasthan, India, December 12th, 2013, invited by Dr Asit Mittal, Evidence based treatment of pemphigus. Collaborative Presentations International Investigative Dermatology, Edinburgh, May 2013 Australasian Society for Dermatology Research, Sydney, May 2013 Speaker - Translational therapies for EB Speaker - Interim results from the STEVIE trial for advanced and metastatic BCC. Loh CH, Kim J, Su J, Daniel BS, Venugopal SS, Rhodes LM, Law M, Murrell DF. Development, Reliability and Validity of a Novel Severity Score for Epidermolysis Bullosa: the Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) (Presented by Clement Loh, Student). Australasian College of Dermatologists, Sydney, May 2013 Speaker – Understanding hedgehog inhibitors for advanced and metastatic basal cell carcinomas. Tran AQT, Lazo-Dizon JP, Kim J, Daniel BS, Venugopal SS, Rhodes LM, Law MG, Murrell DF. Reliability study of four objective outcome measures for atopic dermatitis. Iranian Society of Dermatology, (Profs Dowlati & ChamsDavatchi) June 2013- invited lectures University of Tehran, Research Institute of Dermatology, What’s New in EB? 11th June Evidence Based treatment in AIBD, Razi Hospital. 12th June Novel Specific Therapies for EB & Evidence based Yan WF, Venugopal SS, Frew JW, Rhodes LM,, Melbourne W, Tran K, Murrell DF. Translocation of the cytokine HMGB1 coincides with wound healing in fibroblastinjected wounds of Recessive Dystrophic Epidermolysis Bullosa. 12 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Iwata H, Ludwig RJ, Zillikens, D, Murrell DF and Cowin AJ. Flightless I overexpression impairs skin barrier development, function and recovery post-blistering. Tjokrowidjaja A, Daniel BS, Frew JW, Sebaratnam DF, Hanna AM, Chee S, Dermawan A, Wang CQ, Lim C, Venugopal SS, Rhodes LM, Cochrane J, Welsh B, Nijsten TM, Murrell DF. The development and validation of the TABQOL, a tool to measure the quality of life impacts of treatments used in patients with autoimmune blistering disease. Australasian College of Dermatologists, Sydney, May 2013 Hwang SJ, Daveys J, Fergie B, Rhodes LM, Daniel BS, Murrell DF. Prevalence and characterisation of anaemia in patients with Epidermolysis Bullosa registered in Australia. Loh CH, Kim J, Su J, Daniel BS, Venugopal SS, Rhodes LM, Law M, Murrell DF. Development, Reliability and Validity of a Novel Severity Score for Epidermolysis Bullosa: the Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) (Presented by Clement Loh, Student). Frew JW, Cepeda-Valdes R, Fortuna G. Salas-Alanis JC, Murrell DF. Cross Cultural Adaptation of the “Quality of Life in Epidermolysis Bullosa” (QOLEB) Questionnaire: Validation and Results of Hispanic Translations. Community Engagement Australasian Blistering Diseases Foundation – Patient support group meetings organized on St George Campus and fundraising to support research into life threatening blistering diseases. DebRA Australia – annual meeting in Melbourne to assist EB patients attending. Butterfly Day – fundraising for DebRA –front lobby of St George Hospital. Prof D. Murrell – seeing patients with blistering diseases and teaching abroad HKL, UPM, Islamic University, Kuala Lumpur, Malaysia - 4 weeks Medical mission to see patients and teach medical staff about Epidermolysis Bullosa in Vietnam: FV Hospital, Ho Chi Min & National Paediatric Hospital, Hanoi, accompanied by EB nurse. Arranged visiting apprenticeship for Dr Thach Hoang, Pathologist, National Pediatric Hospital, Hanoi, Vietnam, to learn immunofluorescence mapping of Epidermolysis Bullosa. Interviews with Media Front cover of Rotary Down Under Jan 2012 Issue 535: More than skin deep, about our EB mission to Vietnam. Interview for “Tonic” on ABC TV news segment in health report by Dr Norman Swan, regarding medical spa therapy for atopic eczema, 8th Jan 2012. Interview for A Current Affair on Channel 9, on the new oral drug for basal cell skin cancer, Erivedge, due to the clinical trial we conducted and an interview of one of my trial patients. Thursday February 2nd, 6.45pm, 2012. Conferences and Seminars Organized - Professor D. Murrell Australasian Society for Dermatological Research Conference, Dockside Conference Centre, Darling Harbour, May 22-24th, Sydney 2012, 250 registrants. 8 international speakers. Fundraised for the meeting. Scientific program co-chair. International Society of Dermatology – Continental Congress. Durban, South Africa. Member of the Scientific Committee. Oct 2 27th, 2012. First Australasian Pruritus Conference, Aug 19th, St George Hosp, Sydney, with Dr Frank Brennan. International Society of Dermatology- World Congress. New Delhi, India. Member of Scientific Committee. Dec 4-7th, 2013. 2013 Secured bid for Australia to host the 2021, International Congress of Dermatology, as Congress President, Int’l Society of Dermatology, Melbourne, Australia, November 2021. (successful bid, in India, ICD 2013) Grant Reviewer - Prof DF Murrell, 2012-13 Ludwig Boltzmann Gesellschaft, Austria – up to $1M Euros United States-Israel Binational Science Foundation 2011, grants up to $500K St George Hospital Medical Research Foundation 2012, 2013 University of Modena – Reggio Emilia 2012 PSI Foundation, Canada 2012 Health Research Board, Ireland 2013 Awards Prof DF Murrell • Women’s Dermatologic Society, Mentor of the Year Award, 2013 (Presented at the American Academy of Dermatology, Miami, USA). • International League of Dermatologic Sciences – Certificate of Appreciation for contributions to International Dermatology education and volunteerism. 13 Mae Ramirez • Women’s Dermatologic Society and AAD International Travel Grant, 2012 to present our research at the AAD, Miami 2013. • International Society of Dermatology Mentorship Grant to spend 3 months with Dr Antonella Tosti at the University of Miami, Florida, 2013. Deshan Sebaratnam • Medical Dermatology Society Mentorship Grant to validate our ABQOL measure in the USA at the University of Pennsylvania with collaborator Dr Victoria Werth. • Brenan Prize, Australasian Society for Dermatopathology, for a project on BRAF mutations in diffuse melanosis. Clement Loh • Japanese Society for Investigative Dermatology award to present our research on the validation of a new score for EB at the International Investigative Dermatology meeting in Edinburgh, May 2013. • Dean’s List Award for Research for his project on development and validation of the EBDASI 2013. 14 > Emergency Department, St George Hospital Head of Department Trevor Chan MB ChB, Dip Paeds, FACEM Research Staff Stephen Asha, BSc, MBBS, FACEM, MMed(Clin Epi Director of Emergency medicine Research, Emergency Department, St George Hospital Senior Lecturer (Conjoint), UNSW Alana Clements, CNC Allan Ajami NUM Joanne Plowes CNS Jacqui Fong NP Kate Jarrett CNE Alison Berry CNS Bernadine Romero CNC Margaret Fry CNC Liz Walter CNS Lauren Neuhaus NE Megan Foreshew A/NUM George Bayeh CNS Leanne Horvat SESLHD Emergency Stream Manager Junior Medical Andrew Cooke MBBS; DCH; LLB; LLM Rizwan Qureshi MBBS, MRCS Ed Daniel Honneyman, MbChB Richard Pryor, MD, ABEM Research Projects in Progress A Randomised Controlled Trial of Conservative versus Interventional Treatment of Primary Spontaneous Pneumothorax. Australian New Zealand Clinical Trials Registry (ANZCTR), registration number ACTRN12611000184976. Multicentre trial, Principal Investigator: Dr Stephen Asha. T3 Trial: Triage, Treatment and Transfer of Patients with stroke in Emergency Departments. Nursing Research Institute, Australian Catholic University. Multicentre trial, Principal Investigator: Dr Stephen Asha. Asia, Australia and New Zealand dyspnoea in the Emergency Department Study. Co-ordinating investigator: Anne-Maree Kelly, Western Health, Victoria. Multicentre trial, Principal Investigator: Dr Stephen Asha. Three month outcome of patients with suspected acute coronary syndrome using point of care troponin testing compared with laboratory based troponin testing: a randomised trial. Asha SE, Cooke A, Walter E, Weaver J. Benztropine for the relief of acute non-traumatic neck pain – a randomised trial. Asha S, Kerr A, Jones K, McAlpine A. Sensitivity and specificity of CT scanning for determining the number of internally concealed packages in ‘bodypackers’. Asha SE, Higham M, Child P. Accuracy of emergency physicians and trainees at identifying internally concealed drugs on CT: do ‘lung windows’ improve accuracy. Asha SE, Cooke A. Does the implementation of a Chest Injury Protocol (ChIP) for patients with blunt thoracic trauma reduce complications and improve outcome? Curtis K, Asha SE, Unsworth A, Langcake M. Diagnostic utility of retinal vein pulsation on ophthalmoscopy for predicting serious intra-cranial pathology. Asha SE. Factors associated with in-hospital death among elderly patients sustaining a traumatic subdural haemorrhage. Asha SE, Keady J, Curtis K, Kohan, S. The effect of a nurse team leader on communication and leadership in major trauma resuscitations. Clements, A, Curtis K, Horvat L, Shaban R. Pre-Post test comparison of the impact of sepsis guidelines in ‘time to antibiotics’ in one emergency department” Romero B, Horvat L and Fry M Assessment and management of the cognitively impaired older person presenting to emergency departments with musculoskeletal conditions and injuries. Fry M, Arendts G, Chenoweth L, Macgregor C, Dee K, Vardell W Romero B. Exploration of the insertion and use of peripheral IV cannulas in one emergency department. Romero B, Berry A and Fry M. Original Peer-Reviewed Publications 2012 Asha SE, Curtis K, Grant N, Taylor C, Lo S, Compagnoni K. Comparison of radiation exposure of trauma patients 15 from diagnostic radiology procedures before and after the introduction of a ‘panscan’ protocol. Emergency Medicine Australasia 2012; 24: 43-51. (Editorial regarding this article published in same issue: Stengel, D. Rebalancing the major trauma computed tomography pan-scan between panacea and pandora’s box. Emergency Medicine Australasia 2012;24: 1-3) Jamali S, Asha SE. Reproducibility of the seated reduction technique for anterior shoulder dislocation when performed by doctors with minimal experience in the technique. Emergency Medicine: open access. 2012; 2:109 doi:10.4172/2165-7548.1000109 Qureshi R, Asha SE, Zahra M, Howell S. Factors associated with failure to follow up with a general practitioner after discharge from the emergency department. Emergency Medicine Australasia. 2012; 24: 604-609. of motion of the cervical spine using a tape measure. Journal of Manipulative and Physiological Therapeutics. 2013; 36(8): 538-545. Asha SE, Ajami A. Improvement in emergency department length of stay using an early senior medical assessment and streaming model of care: A cohort study. Emergency Medicine Australasia. Published online first 2013 doi: 10.1111/1742-6723.12128 Arora M, Asha S, Chinnappa J, Diwan AD. Burnout in emergency Physicians – a review. Emergency Medicine Australasia. 2013; 25(6): 491-5. Fry M, Horvat L, Roche M, Fong J, Plowes J (2013) A four month prospective descriptive exploratory study of patients receiving antibiotics in one Emergency Department. International Emergency Nursing 21:163-167. Clements A, Curtis K (2012) What is the impact of nursing roles in hospital patient resuscitation? Australasian Emergency Nursing Journal 15:108-115. Fry M, MacGregor C, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet W (2013) Nursing praxis, compassionate caring and interpersonal relations: An observational study. Australasian Emergency Nursing Journal 16:37-44. Curtis K, Caldwell E, Delprado A, Munroe B (2012) Traumatic injury in Australia and New Zealand. Australasian Emergency Nursing Journal 15:45-54. Presentations at Scientific Meetings and Conferences Fry M, Horvat L, Roche M, Fong J, Plowes J (2012) The prevalence and triage characteristics of patients presenting with infection to one tertiary referral hospital. Australasian Emergency Nursing Journal 15:127-132. Fry M, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet W (2012) Managing the wait: Clinical initiative nurses’ perceptions of an extended practice role. Australasian Emergency Nursing Journal 15:202-210. 2013 Asha SE, Curtis K, Taylor C, Kwok A. Patient controlled analgesia compared to interval analgesic dosing for reducing complications in blunt thoracic trauma: a retrospective cohort study. Emergency Medicine Journal. 2013; 30: 1024-8. Nichols M, Acker J, Bendall J, Asha SE. Evaluating the incidence of unrecognised oesophageal intubation by paramedics. Journal of Paramedic Practice. 2013; 5(4): 212-18. Asha SE, Chan ACF, Walter E, Kelly PJ, Morton RL, Ajami A, Wilson RD, Honneyman D. Impact from point of care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and cost-effectiveness analysis. Emergency Medicine Journal. Published online first: 7 June 2013 doi:10.1136/ emermed-2013-202632. Asha SE, Pryor R. Validation of a method to assess range 16 2012 – National Qureshi R, Asha SE, Zahra M, Howell S.. Factors associated with failure to follow up with a general practitioner after discharge from the emergency department. Evidence review in Emergency Medicine, November 2012, Terrigal, NSW. Nichols M, Acker J, Bendall J, Asha SE. Incidence of unrecognised oesophageal intubation in patients intubated by paramedics and transported to an Australian metropolitan tertiary hospital. Paramedics Australasia Conference, Hobart, 2nd December 2012. Ajami A (2012) The First Aid Skills Training (FAST) Project. Multicultural health research to practice forum: St George Hospital, NSW. Ajami A, Chan DT (2012) Medical Assessment and Decision Making in Emergency (MADMEN) Project. Australasian Redesigning Healthcare Summit, Brisbane. Curtis K, Clements A, Curtis K, Holzhauser K, Horvat L (2012) The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. Trauma 2012 Conference: Perth. Curtis K, Clements A, Holzhauser K, Horvat L (2012) The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. 10th International Conference for Emergency Nursing: Hobart. Horvat L, Fry M, Plowes J, Fong J (2012) To explore the nursing assessment and initial management of septic patients in the Emergency Department. Annual Critical Care Conference Hunter Valley, NSW. Romero B (2012) The emergency flow Coordinator International Conference of Emergency Nursing: Hobart. Romero B (2012) To identify delay reasons for ED patients at 4 and 8 hours allowing the early identification and escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference Hunter Valley, NSW Romero B, Ajami A, Bayeh G, Neuhaus L, Foreshew M, Cosgrove J (2012) To identify delay reasons for Ed patients at 4 and 8 hours allowing the early identification and escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference: Hunter Valley, NSW. 2013 – International Reproducibility of the seated reduction technique for anterior shoulder dislocation when performed by doctors with minimal experience in the technique. Presented as an abstract in the scientific sessions of the International Conference on Nursing & Emergency Medicine (Nursing-2013), Las Vegas, USA, December, 2013. 2013 - National Asha SE, Pryor R. Validation of a method to assess range of motion of the cervical spine using a tape measure. Evidence review in Emergency Medicine, March 2013, Terrigal, NSW. Chinnappa J, Arora M, Asha S, Diwan AD. Career satisfaction among Australian emergency medicine staff: a two centre cross sectional study (poster). Australasian College for Emergency Medicine ACEM annual scientific meeting, Adelaide, November 2013. Arora M, Asha S, Diwan AD. Over half of emergency medicine staff are burned out: Results from a two-center cross-sectional study (poster) ACEM annual scientific meeting, Adelaide, November 2013. Walter L (2013) Impact from point of care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and costeffectiveness analysis. International Conference of Emergency Nursing: Melbourne. 17 > Emergency Department, Sutherland Hospital Head of Department Research Projects in Progress January 2012- November 2013 Dr David Mah, FACEM, DHA, Conjoint Lecturer UNSW. November/December 2013 Dr Enasio Morris FACEM (Locum Director). Professional Development Process Pilot Study. G.Watkins (principal investigator TSH), A. Moore, I. Ozelin. Staff Specialists Dr Andrea Bell, FACEM DCH Dr Murali Krishnaraj FACEM Dr Jeffrey Lui, FACEM Dr David Mah FACEM, DHA, Lect (conjoint) UNSW Dr Allison Moore FACEM Associate Prof. John Raftos, FACEM, Snr Lect (conjoint) UNSW Dr Katerina Tsacalos FACEM Dr Gina Watkins BSc(Hons), DRCOG, MRCGP, FACEM, Lect (conjoint) UNSW Dr Luis Winoto FACEM Dr Peter Wyllie FACEM A Randomised Controlled Trial of Conservative versus Interventional Treatment of Primary Spontaneous Pneumothorax. Australian New Zealand Clinical Trials Registry (ANZCTR), A. Moore (principal investigator TSH). Benztropine for the relief of acute non-traumatic neck pain randomised trial. Asha S, Kerr A, Jones K, McAlpine A (principal investigator TSH). Presentations at Scientific Meetings and Conferences 2012 National Impact of Emergency Department Transfer Form Mah, D. International Conference on Emergency Medicine, Dublin June. Visiting Medical 2013 - International Dr Javad Najafi FACEM Dr James Parks FACEM G Watkins, Emergency Medicine Training in Australasia: Nepal Emergency Medicine Seminar, Kathmandu, April. Nursing G Watkins, Acute Nerve Injury Pain Management: 4TH International Congress on Neuropathic Pain, Toronto May. Ann McAlpine, Nurse Practitioner 2013 - National G Watkins, Emergency Department Management of Acute Nerve Injury Pain: A review. Australasian College for Emergency Medicine (ACEM) Annual Scientific Meeting, Adelaide, November. A Moore, Emergency Department Morbidity Audit, ACEM Annual Scientific 18 > Department of Endocrinology Head of Department Associate Professor Anthony O’Sullivan MBBS, FRACP, MD, MHPEd Senior Medical Staff Specialists Associate Professor Terrance Diamond MB, BCh, MRCP, FRACP Dr Peter Rohl MBBS, FRACP Dr Ganesh Chockalingham MBBS, FRACP, FRACGP Dr Majgorzata Brzozowska MD, FRACP Visiting Medical Dr Mary Freeman MBBS, FRACP Junior Medical Advanced trainees Dr Bobby Chan 2013 Dr Aimee Hayes 2012 Senior Researcher Terry Golombick PhD Dipl Nutr Research Grants St George Hospital: Multicultural Health Service Cultural Diversity Health Enhancement Grants Program. Craig D, Fernandez R (2013) Clinical Management of Chinese speaking women with Gestational Diabetes Mellitus speaking women with Gestational Diabetes. 2012- 2013. $6,800. Research Projects in Progress Changes in body composition and energy metabolism during pregnancy: predictive of preeclampsia and gestational diabetes mellitus? Principal investigators, A/ Prof Anthony J O’Sullivan, Odetta Davison. Original Peer-Reviewed Publications M M Brzozowska, P Davoren, “Does critical illness cause reversible Cushing’s like syndrome? A case study of two case reports and review of the literature”Journal of Diabetes and Endocrinology Vol. 3(2), pp. 22-24, March 2012. O’Sullivan AJ, Howe A, Miles S, Harris P, Hughes CS, Jones P, Scicluna H, Leinster S. Does a summative portfolio foster the development of capabilities such as reflective practice and understanding ethics? An evaluation from two medical schools. Medical Teacher 2012; 34: e21-e28. Imison M, Harris P, Hewson L, Jones P, McNeil PH, Moore K, O’Sullivan AJ, Velan G, Hughes C. A Bank of Stories: Piloting Low-Fidelity, Student-Generated Virtual Patient Cases in Undergraduate Medical Education. Focus on Health Professional Education 2012; 13: 22-31. Scicluna H, Grimm MC, O’Sullivan AJ, Pilotto L, Jones P, McNeil HP. Clinical capabilities of graduates of an outcomes-based integrated medical program. BMC Medical Education 2012; 12: 23-30. Morris J, O’Sullivan AJ. Body fat increases throughout pregnancy despite no significant changes in 24-hour energy expenditure and caloric intake. Obesity Research and Clinical Practice 2012; supp 1: 59-60. Golombick T, Diamond T, Manoharan A and Ramakrishna R. Response to Vermorken et al – curcumin and free light chains. American J Hematology 2012;87:E80-E81. DOI:10.1002/ajh.23294 . Golombick T, Diamond T, Manoharan A and Ramakrishna R. Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM) and Curcumin: A Randomised, Double-blind PlaceboControlled Cross-over 4g study and an Open-label 8g Extension Study. American J Hematology. 2012;87:455460. MM Brzozowska, A Sainsbury, J Eisman, P Baldock, J Center. Bariatric surgery, bone loss, obesity and possible mechanisms. Obesity Reviews 2013 14(1):52-67- selected as “Hot topic publication” by ESA society. Olupeliyawa Asela M, Balasooriya CD, Hughes C, O’Sullivan AJ. Commencing clinical practice as a medical graduate: what collaborative behaviors and competencies are critical? Focus on Health Professional Education 2013; 14: 57-70. Chan B, O’Sullivan AJ. Investigating disorders of hyponatraemia. Endocrinology Today 2013; 2: 38-40. Mavros Y, Kay S, Anderberg KA, Baker MK, Wang Y, Zhao R, Meiklejohn J, Climstein M, O’Sullivan A, De Vos N, 19 Baune B, Blair SN, Simar D, Rooney K, Singh N, Fiatorone Singh MA. Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with Type 2 Diabetes: Interim outcomes from the GREAT2DO trial. Diabetes Care 2013, published online March 8. Tang A, O’Sullivan AJ, Diamond D, Gerard A, Campbell P. Psychiatric symptoms as a clinical presentation of Cushing’s syndrome. Annals of General Psychiatry 2013; 12: 23. Wong R, Golombick T, Diamond T, Manoharan A and Ramakrishna R. Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells. J Hematological Malignancies, 2013,Vol 3, no 2,1-7. Golombick T, Diamond T, Manoharan A and Ramakrishna R. Long term use of curcumin in two smoldering multiple myeloma patients. J Hematological Malignancies, 2013, Vol 3, no 1, 18-23. Diamond T, Golombick T and Wong Y. The effect of oral cholecalciferol 2000 IU versus 5000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporosis International (2013)24:11011105. Denham JW, Nowitz, M, Joseph D, Duchesne G, Spry NA, Lamb DSs, Matthews J, Turner S, Atkinson C, Tai KH, Gogna NK, Kenny L, Diamond T, Smart R, Rowan D, Moscato P, Woodfield R, Lynch K, Dalahunt, Murray J, D’Este C, McElduff P, Steigler, A, Kautto A, and Ball J. Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans-Tasman Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) randomized controlled trial for locally advanced prostate cancer. BJU International October 15 2013 Doi: 10.111/ bju.12497. Bokhari AR, Davies MA. Diamond T. Endoscopic transsphenoidal pituitary surgery: a single surgeon experience and the learning curve. British J of Neurosurgery. 2013 February 27(1) 44-49. Presentations at Scientific Meetings and Conferences International Brzozowska, M. Differential bone loss following gastric surgery at 12 months-late breaking abstract with oral presentation at the 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Minneapolis, Minnesota, October 2012. Mavros Y, Rooney K, Kay S, Simar D, Anderberg K, Baker 20 M,Wang Y, Zhao R, Climstein M, O’Sullivan AJ, Baune B, Blair S, Fiatarone-Singh M. Relative muscle mass is inversely associated with inflammation in older adults with Type 2 diabetes. 3rd World Congress on Exercise is Medicine, San Francisco, CA 2012. No 1103. Mavros Y, Rooney K, Kay S, Simar D, Anderberg K, Baker M,Wang Y, Zhao R, Climstein M, O’Sullivan AJ, Baune B, Blair S, Singh N, Fiatarone-Singh M. Relative muscle mass is inversely associated with insulin resistance in older adults with Type 2 diabetes. 19th European Congress of Obesity, Lyon, France 2012. No. 851. Morris J, O’Sullivan AJ. Body fat increases throughout pregnancy despite no significant changes in 24-hour energy expenditure and caloric intake. Australian & New Zealand Obesity Society Annual Scientific Meeting, Auckland, New Zealand 2012. Golombick T, Diamond T, Manoharan A and Ramakrishna R. Multiple Myeloma Precursor Disease and Curcumin. 14th International Myeloma Workshop, April 3-7, 2013, Kyoto, Japan. Golombick T, Wong R, Diamond T, Manoharan A and Ramakrishna R. Curcumin Enhances the Cytotoxic and Chemosensitising Effects of Lenalidomide in Human Multiple Myeloma Cells. Fourteenth International Myeloma Workshop, April 3-7, 2013, Kyoto, Japan. Brzozowska, M. Bone loss following bariatric surgery: Comparison of different modalities, featured poster presentation, The Endocrine Society 95th Annual Meeting, San Francisco 2013 (awarded Postgraduate Research Support Scheme (PRSS) Grant UNSW). National Malgorzata Brzozowska “Bone loss following bariatric surgery: Comparison of different modalities”-Endocrine Society of Australia (ESA) Conference Sydney, Darling Harbour, April 2013 (ESA Novartis Award Finalist). Jones P, O’Sullivan AJ, Velan G, Thompson R, Balasooriya C, Kumar R, Harris P. A programmatic approach to standards-based assessment in medicine. Learning and Teaching Forum: Assurance of Learning, UNSW, Sydney, 2012. Hayes A, Iskander A, O’Sullivan AJ, Diamond D. Will new GDM diagnostic criteria impact on resource allocation as defined by GDM prevalence and proportion of women requiring insulin therapy? Australian Diabetes in Pregnancy Society Annual Scientific Meeting, Gold Coast, 2012. Morris J, O’Sullivan AJ. Accumulation of body fat during pregnancy occurs despite no significant changes in energy expenditure and caloric intake. Australian Diabetes in Pregnancy Society Annual Scientific Meeting, Gold Coast, 2012. White C, Chen K, Lip C, Lee J, XuGuang H, Hong A, Bleicher K, Lowe S, O’Sullivan A.J. Vitamin D insufficiency is prevalent but does not influence glycaemia in pregnancy. Annual Scientific Meeting of the Endocrine Society of Australia, Gold Coast 2012. Since commencement of the Group 244 participants have attended groups. The majority of referrals have been from The Diabetes Education Centre. Community Engagement Introduction of a weekly block booking Chinese Interpreter supported Chinese speaking Gestational Diabetes review clinic. This clinic has improved access for these women and provided opportunities for regular review and psychosocial support. The Diabetes Group Report The Diabetes Education Centre continues to provide a service to the St George Division of General Practice for a group education program. The target group suffers from insulin resistance, impaired fasting glucose, Type 2 patients. Referral sources included: • Diabetes Education Centre, • Diabetes Clinic, • Nutrition department, • Other Allied Health • General Practitioners. Chinese Speaking Gestational Diabetes Mellitus Clinic Awards Dr Malgorzata Brzozowska NHMRC (National Health and Medical Research Council) scholarship for the PhD project, UNSW: “The association between neuropeptides, gut hormones, skeletal and metabolic health”. 2009-2013 Exclusions: Non English speaking and children. Venue: Division of General Practice The program consisted: Session 1 Understanding your condition Session 2 Nutrition Session 3 Podiatry Session 4 Ophthalmology Session 5 Nutrition Session 6 Physical Activity Each session except session 1 contain physical activity component The session given by the educator includes the following topics: 1. Healthy eating (brief as covered by dietitian) 2. Being Active (brief as covered by exercise physiologist) 3.Monitoring 4. Taking Medication 5. Problem Solving 6. Healthy Coping 7. Reducing risks 21 > Department of Gastroenterology and Hepatology Head of Department A/Prof Amany Zekry, MBBS, PhD, FRACP, Associate Professor of Medicine Senior Medical Prof Ian Cook, MBBS, FRACP, MD, Professor of Medicine (Conjoint) Prof Michael Grimm, MBBS (Hons), PhD, FRACP, Clinical Associate Dean, St George and Sutherland Clinical School. A/Prof Philip Craig, MBBch, PhD, FRACP, Associate Professor of Medicine (Conjoint) Dr John Freiman, MBBch, PhD, FRACP Dr Lennart Choo, MBBS, FRACP Dr Gokulan Paven, MBBS, FRACP, Snr Lecturer (Conjoint) Junior Medical Dr Peter Wu, MBBS Dr Peter Lim, MBBS Dr Vipul Aggarwal, MBBS Research Staff Dr Michal Szczesniak, BBiomedSc (Hons), PhD, Post-Doc Research Fellow, St George and Sutherland Clinical School Ms Teng Zhang, MBiomedEng, PhD student, St George and Sutherland Clinical School Dr Greta Lee, MB BS, MMed (Clin. Epi.), FRACP, PhD student, St George and Sutherland Clinical School Ms Annie Luo, BSc (Hons), PhD student, St George and Sutherland Clinical School Ms Linda El-Bayeh, BSc (Hons), Research assistant, St George and Sutherland Clinical School Ms Lisa Dowdell Clinical Nurse Consultant – Community Liver Disease Ms Amy Ko - Clinical Trials Coordinator Research Grants NHMRC Project Grant Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy, I Cook, M Szczesniak, J Maclean, P Graham, T Omari $301,624 0; (2013 - 2015). NHMRC Project Grant, Development of diagnostic tools to characterise predictors of therapeutic outcome in severe constipationPG Dinning, I Cook, J Arkwright, M Scott, DZ Lubowski, $418,500; (2010 – 2012). UNSW MREII scheme Veneflux system, Multiple platelet 22 function analyzer, Fluoroskan Ascent FL fluorescent plate reader, Leica inverted fluorescence microscope, Grimm MC, O’Sullivan A, Chong B, Krilis SA, Morris DL $240,722 (2012). NHMRC Equipment grant + UNSW MREII scheme Tuttnauer Autoclave, Step One Plus 96 well Quantitative PCR Machine, AKTA Avant 150 FPLC System, Direct Detect Spectrometer Grimm MC, Chong B, Krilis S, Morris DL, Li Y.$353,190 , (2013). UNSW MREII scheme, Establishment of a biostatistical unit for UNSW Medicine, Hayen A, McIntyre R, Harris M, Lassere M, Grimm MC, Zwar N, Worth H. $387,905, (2013). UNSW MREII scheme, Lloyd AR, Grimm MC and 15 other investigators Bioplex Magpix with wash station, $71,138 (2013). Research Projects in Progress Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy. Principal investigators: I Cook, M Szczesniak, J Maclean, P Graham, T Omari. Prospective, randomized controlled trial of cricopharyngeal dilatation in post-laryngectomy dysphagia. Principal investigators: P Wu, M Szczesniak, J Maclean, I Cook. Influence of altered pharyngo-esophageal biomechanical parameters on swallowing and speech function in laryngectomees, Principal investigators: T Zhang, M Szczesniak, J Maclean, P Bertrand, I Cook. The role of Campylobacter concisus in the pathogenesis of IBD, Principal investigators: Zhang L, Grimm MC, Riordan S. The appendix, appendicitis, and the immunology of protection against IBD, Principal investigators: Luo AS, Philips P, Grimm MC. The role of the chemokine-chemokine receptor pair, CCL20-CCR6, in intestinal immunity and inflammation, Principal investigators: Eri R, Lyons AB, Korner H, Grimm MC. The role of balloon-assisted cholangioscopy, Principal investigators: Lim P, Craig P. Capsule endoscopy study of small bowel Crohn’s disease patients in clinical remission, Principal investigators: Aggarwal V, Day AS, Connor SJ, Leach ST, Brown, GJ. Singh R, Friedman A, Grimm MC, Craig, PI. Gilead 121. Phase 2 Randomized, Open-Label, Exploratory Trial of GS 5885, GS 9451 with Peginterferon Alfa 2a (PEG) and Ribavirin (RBV) in Treatment-Naïve subjects with chronic Genotype 1 Hepatitis C virus Infection and IL28B CC Genotype Principal investigator: A/Prof. Amany Zekry. interferon-α and ribavirin in Treatment-naïve patients with Chronic Genotype 1b HCV Infection. Principal investigator: A/Prof Amany Zekry. A Multi centred 3 year follow up study to assess the durability of sustained virologic response to Alisporivir treated chronic HCV patients. Principal investigator: A/Prof Amany Zekry. Gilead – FISSION. Phase 3, Multicenter, Randomized, Active-controlled Study to investigate the safety and efficacy of PSI-7977 and Ribavirin for 12 weeks Compared to Pegylated Interferon and Ribavirin for 24 weeks in treatment-naïve patients with chronic genotype 2 or 3 HCV infection, Principal investigator: A/Prof Amany Zekry. A Multicenter, Randomized, Double-blind, Phase 3 Study of Ramucirumab (IMC-1121B) Drug Product and Best Supportive Care (BSC) versus Placebo and BSC as Secondline Treatment in Patients With Hepatocellular Carcinoma F ollowing First-line Therapy. Principal investigator: A/Prof Amany Zekry. Gilead 109. Open label study of GS7977 and Ribavirin for 12 weeks for subjects with chronic HCV infection who participated in prior studies evaluating GS7977, Principal investigator: A/Prof Amany Zekry. Original Peer-Reviewed Publications Phase 3, Open Label study with Asunaprevir and Daclastasvir (DUAL) for Null/partial responders to Peg Alfa 2a and Ribavirin, Intollerant/Ineligible naïve to P/R subjects, and treatment naïve subjects with chronic HCV genotype 1b, Principal investigator: A/Prof Amany Zekry. BMS-A1444-026. An open-label re-treatment study with Peg-Interferon Alfa-2, Ribavirin and BMS-7090052 with or without BMS-650032 for subjects with Chronic Hepatitis C, Principal investigator: A/Prof Amany Zekry. Novartis DEB025A2210. A phase II clinical trial to evaluate the efficacy and safety. A multicentre, randomized, doubleblind, placebo-controlled, parallel-group phase II study on the efficacy and safety of DEB025/Alisporivir combined with peg-IFN alfa-2a and ribavirin in chronic hepatitis C genotype 1 patients who are previous peg-IFN alfa-2 plus ribavirin treatment-non-responders, Principal investigator: A/Prof Amany Zekry. Novartis DEB025A2301. A randomized, double-blind, placebo-controlled trial of the efficacy and safety of DEB025/Alisporivir in combination with standard of care in hepatitis C genotype 1 treatment naïve patients. Principal investigator: A/Prof Amany Zekry. A Phase III, Randomised, open label, parallel group, Active-controlled study of an interferon-free regimen of BI 207127 in combination with Faldaprevir and Ribavirin compared to Telaprevir in combination with pegylated 2012 Dinning PG, Hunt L, Arkwright JW, Patton V, Szczesniak MM, Wiklendt L, Davidson JB, Lubowski DZ, Cook IJ. Pancolonic motor response to sub-and suprasensory sacral nerve stimulation in patients with slow transit constipation. Br J Surg. 2012; 99(7):1002-10. P.I. Craig, The role of endoscopic stenting for biliary strictures in chronic pancreatitis. Dig Endosc. 2012; 24(Suppl 1):38-42. McNeil HP, Scicluna H, Boyle P, Grimm MC, Gibson KA, Jones P. Successful development of generic capabilities in an undergraduate medical education program. Higher Education Research and Development 2012; 31:525-539. Ismail Y, Mahendran V, Octavia S, Day AS, Riordan SM, Grimm MC, Lan R, Lemberg D, Tran TAT, Zhang L. Investigation of the enteric pathogenic potential of oral Campylobacter concisus strains isolated from patients with inflammatory bowel disease. PLoS ONE 2012; 7(5):e38217. Scicluna H, Grimm MC, O’Sullivan AJ, Pilotto L, Jones P, McNeil HP, Clinical capabilities of graduates of an outcomes-based integrated medical program. BMC Medical Education 2012; 12:23-28. Choo L, Conway J, Mishra G. The role of endoscopic ultrasound in biliary obstruction. Current Gastroenterology Reports 2012; 14(6): 520-7. Keoshkerian E, Helbig K, Beard M, Zaunders J, Seddiki N, 23 Kelleher A, Hampartzoumian T, Zekry A, Lloyd AR. A novel assay for detection of hepatitis c virus-specific effector cd4(+) t cells via co-expression of cd25 and cd134. Journal of immunological Methods 2012;375:148-158. Guirgis M, Yan K, Bu YM, Zekry A. General practitioners’ knowledge and management of viral hepatitis in the migrant population. Internal Medicine Journal 2012; 42:497-504. Guirgis M, Nusair F, Bu YM, Yan K, Zekry AT. Barriers faced by migrants in accessing healthcare for viral hepatitis infection. Internal Medicine Journal 2012; 42:491-496. 2013 Szczesniak MM, Fuentealba SE, and Cook IJ. Acid Sensitization of Esophageal Mucosal Afferents: Implication for Symptom Perception in Patients across the Gastroesophageal Reflux Disease Spectrum. Clin J Pain 2013; 29(1):70-7. Elliott TR, Wu PI, Fuentealba S, Szczesniak M, de Carle DJ, Cook IJ. Long-term outcome following pneumatic dilatation as initial therapy for idiopathic achalasia: an 18-year single-centre experience. Aliment Pharmacol Ther. 2013; 37(12):1210-9. Mahendran V, TanYS, Riordan SM, Grimm MC, Day AS, Lemberg DA, Octavia S, Lan R, Zhang L. The prevalence and polymorphisms of zonula occluden toxin gene in multiple Campylobacter concisus strains isolated from saliva of patients with inflammatory bowel disease and controls. PLoS ONE 2013; 8(9):e75525. Zbaras B, Sam LN, Grimm MC. Thrombotic thrombocytopaenic purpura associated with adalimumab (Humira) treatment in Crohn disease. Internal Medicine Journal 2013; 43(2): 216-217. Other Published Material Cook IJ. Investigating the patient with difficulty swallowing: The importance of a thorough history. Medicine Today 2012;13(9):48-53. Cook IJ. Zenker’s Diverticulum. In: Shaker R, Postma G, Belafsky P, Easterling C, Eds Principles of Deglutition: A Multidisciplinary Text for Swallowing and its Disorders. New York: Springer: 2013. (ISBN 978-1-4614-3794-9). Cook IJ. Globus Pharyngeus In: Shaker R, Postma G, Belafsky P, Easterling C, Eds Principles of Deglutition: A Multidisciplinary Text for Swallowing and its Disorders. New York: Springer: 2013. (ISBN 978-1-4614-3794-9). Kumbhari V, Behary J, Szczesniak M, Zhang T, Cook IJ. Efficacy and safety of pneumatic dilatation for achalasia in the treatment of post-myotomy symptom relapse. Am J Gastroenterol. 2013; 108(7):1076-81. Presentations at Scientific Meetings and Conferences Szczesniak MM, Fuentealba SE, Zhang T, Cook IJ., Modulation of esophageal afferent pathways by 5-HT3 receptor inhibition. Neurogastroenterol Motil. 2013; 25(5):383-8, e293. I.J. Cook, Newer understanding of UES function with high resolution manometry. Joint International Neurogastroenterology and Motility Conference, Bologna, Italy, Sept 2012. Ismail Y, Lee H, Riordan SM, Grimm MC, Zhang, The effects of oral and enteric Campylobacter concisus strains on expression of TLR4, MD-2, TLR-2, TLR5 and COX-2 in HT-29 cells. PLoS ONE 2013; 8(2):e56888. V. Kumbhari, J. Behary, M.M. Szczesniak, M. Naidoo, I.J. Cook, Efficacy and Safety of Pneumatic Dilatation in Patients With Achalasia Who Relapse Post Heller Myotomy. Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, Page S-282. Walsh AJ, Weltman M, Burger D, Vivekanandarajah S, Connor S, Howlett M, Radford-Smith G, Selby W, Veillard AS, Grimm MC, Travis SPL, Lawrance I. Implementing guidelines on the prevention of opportunistic infections in inflammatory bowel disease. Journal of Crohn’s and Colitis. 2013; 7:e449–e456. Handford C, Burton A, Lemon J, Grimm MC, VollmerConna U. Reading emotion in the eyes: empathy as a function of clinical exposure. PLoS ONE 2013; 8(6):e65159. Lee AYS, Eri R, Lyons AB, Grimm MC, Korner H. CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: Odd couple or axis of evil?Frontiers in Mucosal Immunity 2013; 4:194-200. 24 2012 - International S. Paramsothy, J. Maclean, M. M. Szczesniak, I. J. Cook. Cricopharyngeal Dilatation for Post Laryngectomy Dysphagia - a Pilot Study of Efficacy and Safety. Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, Page S-235. S. Paramsothy, J. Maclean, M. M. Szczesniak, I. J. Cook. Oesophageal Dysmotility in Laryngectomy Patients - is There an Association? Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, Pages S-235-S-236. P.I. Craig, Contrast capsule endoscopy: The Australian experience. Capsule Endoscopy Experts Forum CEEF, Vienna, February. V. Aggarwal, A.S. Day, S.J. Connor, S.T. Leach, G.J. Brown, R. Singh, A, Friedman, M.C. Grimm, P.I. Craig, “Multicenter capsule endoscopy study of small bowel Crohn’s disease patients in clinical remission: long-term follow-up and correlation with faecal biomarkers and clinical outcome.”, Oral, DDW Gastroenterology 142 (5). Grimm M.C. The appendix in IBD: from epidemiology to mechanism. Oral, Oxford IBD Masterclass, Oxford, UK. 2012 - National Szczesniak M, Fuentealba SE, Cook IJ. Involvement of 5-HT3 neural pathways in oesophageal sensitivity and acid-induced viscerosomatic sensitisation. Oral, Australian Gastroenterology Week, Adelaide, October. Journal of Gastroenterol Hepatol 2012:27(Suppl 4):A155 . Lim P, Craig PI. Balloon-assissted cholangioscopy: technique, diagnostic and therapeutic applications. Oral (video forum), Australian Gastroenterology Week, Adelaide, October. Ghaly S, Craig PI. Over the scope clip to close an entero-cutaneous fistula. Oral (video forum), Australian Gastroenterology Week, Adelaide, October. Lim P, Aggarwal V, Craig PI., Peroral balloon-assisted cholangioscopy for complex biliary disease in a multiethnic cohort. Oral, Australian Gastroenterology Week, Adelaide, October. J Gastroentrol & Heptol, 27 (supp 4):S59. Aggarwal V, Day AS, Connor SJ, Leach ST, Brown GJ, Singh R, Friedman A, Grimm MC, Craig, PI. Multicenter capsule endoscopy study of small bowel Crohn’s disease patients in clinical remission: long-term follow-up and correlation with faecal biomarkers and clinical outcome. Oral, Australian Gastroenterology Week, Adelaide, October, J Gastroentrol & Heptol, 27 (supp 4):S96. PI Craig. Inflammatory lesions , NETI National Endoscopy Training Initiative, capsule course, Sydney; July. PI Craig. Tumours and polyposis syndrome, NETI National Endoscopy Training Initiative, capsule course, Sydney; July. PI Craig. Primary sclerosing cholangitis: Endoscopic management and cholangiocarcinoma diagnosis. ALA Australian Liver Association Masterclass, Sydney, July. PI Craig. New paradigms in pancreatico-biliary diseases: case-based discussion and updates. Gut Club, Sydney; August. PI Craig. Australian Multicentre Balloon-assisted Cholangioscopy Study. Oral, ANZELF Australia & New Zealand Endoscopy Leaders Forum: Darwin; August. PI Craig. Entero-cutaneous fistula closure with an OTSC device. ANZELF Australia & New Zealand Endoscopy Leaders Forum: Darwin; August. PI Craig. Luminal stenting: Do’s and Don’ts. Australian Gastroenterology Week, Adelaide, October. PI Craig. Capsule endoscopy in Crohn’s: Assessing disease remission. Australian Gastroenterology Week, Adelaide, October. Grimm M.C. Inflammatory cascades in IBD, Macarthur Series in Immunology. Campbelltown, NSW. Grimm M.C. Pregnancy and IBD. Society of Obstetric Medicine of Australian and New Zealand Annual Scientific Meeting Sydney, NSW. Choo L, Mishra G, Conway J, Evans J. Prospective single blinded study of EUS prior to ERCP for patients with a positive intra-operative cholangiogram. Oral, Australian Gastroenterology Week. Adelaide, October. Choo L, Mishra G, Evans J, Conway J. Endoscopic ultrasound training: The impact on procedure time and complications. Poster, Australian Gastroenterology Week. Adelaide, October. Wu PI, Szczesniak MM, Craig PI, Choo L. Predictors of rebleeding in high risk peptic ulcer disease in the era of modern endoscopic therapy and high dose intravenous proton pump inhibitors. Poster, Australian Gastroenterology Week. Adelaide, October. Choo L. AGEA update 2013- pancreatico-biliary. Australian Gastroenterology Week, Adelaide, October. 2013 - International M.M. Szczesniak, J. Maclean, T. Zhang, P. Graham, IJ. Cook. Prevalalence of Dysphagia as a long term complication of head and neck radiotherapy, Oral Presenation 3rd Congress of the European Society for Swallowing Disorders, 2013 Malmo, Sweden. M.M. Szczesniak, T.I. Omari, J. Maclean, R. Liu, T. Zhang, I.J. Cook. Inter-rater reliability of automated impedancemanometry (AIM) analysis and fluoroscopy in patients with dysphagia following head and neck radiotherapy. Oral Presenation 3rd Congress of the European Society for Swallowing Disorders, 2013, Malmo, Sweden. M.M. Szczesniak, Cook I.J. Normal values for sydney swallow questionnaire (SSQ), Poster Presentation, 3rd Congress of the European Society for Swallowing Disorders, Malmo, Sweden, 2013. Rebecca Burgell, Michal M. Szczesniak, Priyanka Yerragorla, Emma V. Carrington, Sahar Mohammed, Peter J. Lunniss, Philip G. Dinning, S. Mark Scott. Quality, Intensity and Location of the Urge to Defaecate Differs Between Patients With Constipation and Healthy Subjects, DDW, Gastroenterology, Volume 144, Issue 5, Supplement 25 1, May 2013, Page S-935. Lim P, Craig PI. The role of balloon-assisted cholangioscopy: Diagnosis and Therapy, Oral (video forum) Digestive Diseases Week, Orlando, FA. USA, May. Lim P, Aggarwal V, Craig PI, The role of balloon-assisted cholangioscopy in a multi-ethnic cohort to assess complex biliary disease. Digestive Diseases Week, Orlando, FA. USA, May. National - 2013 PI Craig. Advances in the endoscopic diagnosis of malignancies of the bile duct. Oral, Australian Gastroenterology Week, October, Melbourne. PI Craig. Intrahepatic biliary dysplasia complicating a choledochal cyst: Diagnosis and management. Australian Gastroenterology Week, October, Melbourne. PI Craig. Defining normal and normal variants in capsule endoscopy. NETI National Endoscopy Training Initiative, capsule course, Sydney. PI Craig. Direct Cholangioscopy in 2013 and Beyond. RPAH Biliary Workshop, Sydney. Wu PI, Szczesniak MM, Craig PI, Choo LK. Predictors of rebleeding in high risk peptic ulcer disease in the era of modern endoscopic therapy and high dose intravenous proton pump inhibitors. Australian Gastroenterology Week, October, Melbourne. Grimm M.C. Optimising therapy in IBD. Raising Expectations in Gastroenterology, Sydney and Newcastle. Luo AS, Jung H-J, Philips P., Grimm M.C. The mechanisms of regulatory T cell expansion following appendicitis induction. Poster, Australian Gastroenterology Week, October, Melbourne. 26 > Infectious Disease, Immunology and Sexual Health Head of Department Prof. Steven A. Krilis, MB BS PhD DSc (Hons) FRACP FAAAA, Conjoint Professor of Medicine UNSW Senior Medical Dr. Pamela Konecny, MB BS MD DTM&H(Lon) FRACP FAChSHM Conjoint Snr Lecturer in Medicine UNSW Dr. Chris Weatherall, MB BS PhD FRACP, Conjoint Lecturer in Medicine UNSW Dr. Josephine Lusk, BSc MBChB FRNZCGP DRCOG FAChSHM MPH Dip MGT, Conjoint Senior Lecturer Medicine, UNSW, Director of Sexual Health Dr. Damian Conway, MB BCh, MMed (HIV/STD) FAChSHM MRCGP, Lecturer in Medicine UNSW Dr. Catherine Pell, MBBS MM (Sex Hth) FAChSHM Research Sharon Robinson CNC Clinical Trials Dr. Bill Giannakopoulos MBBS PhD FRACP – Director of Research Dr. Jian Chen Qi Master of Medicine , PhD, Senior Scientist./Laboratory Manager Miao Qi, Bachelor of Medicine in Medical Laboratory Science, MSc (UNSW). Peyman Mirarabshahi, PhD Mahmood Abdelatti MSc Visiting Fellow Dr. Peng Zhang, Bachelor of Clinical Medicine, PhD Visiting Fellow Dr. Siajun Zhou, Bachelor of Clinical Medicine, MSC, PhD Postdoctoral Fellow Dr. Gang Chen, MBBS, PhD Research Grants NHMRC, Tests for risk of thrombosis in patients with certain autoimmune conditions. Principal investigators Steven Krilis, Bill Giannakopoulos, $300,000, $190,000, $190,000, 2012-2014. NHMRC, Delineation of the role of RasGRP4 in mast cell growth, differentiation and activation, using RasGRP4 deficient mice. Principal investigator Steven Krilis $204,500 yearly, 2010-2012. UNSW Goldstar Award, The role of Mast cell specific proteases in inflammatory bowel disease in mice and humans. Principal investigators Steven Krilis, Michael Grimm $40,000, 2012. St. George & Sutherland Medical Research Foundation, Innate Immunity in Thrombosis and Ischaemia Perfusion Injury Principal investigators Steven Krilis, $30,000, 2013. NSW Ministry of Health, NSW Rapid HIV Testing Evaluation Framework, Principal Investigators: Rebecca Guy, Garrett Prestage Damian Conway, Martin Holt, Andrew Grulich, John Kaldor, Philip Cunningham, $433,210 over 2 years (2013-2014). Australian Rotary Health & The Kirby Institute HIV PhD Scholarship, Novel approaches to HIV testing for men who have sex with men, Investigator: Damian Conway, $72,000 over 2.5 years (January 2012-July 2014). Research Projects in Progress Delineation of the role of RasGRP4 in mast cell growth, differentiation, Principal investigator: Steven Krilis. Tests for risk of thrombosis in patients with certain autoimmune conditions , Principal investigators Bill Giannakopoulos, Steven Krilis. NSW Rapid HIV Testing Evaluation Framework, Principal Investigators: Rebecca Guy, Garrett Prestage Damian Conway, Martin Holt, Andrew Grulich, John Kaldor, Philip Cunningham. Original Peer-Reviewed Publications 2012 Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 8;287(24):20047-55. Giannakopoulos B, Gao L, Qi M, Wong JW, Yu DM, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, Koike T, Hogg P, Qi JC, Krilis SA. Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis. J Autoimmun. 2012 Sep;39(3):121-9. Giannakopoulos B, Mirarabshahi P, Krilis S. New insights into the biology and pathobiology of Beta 2-glycoprotein I. Curr Rheumatol Rep. 2012;13:90-5. Mirarabshahi P, Abdelatti M, Krilis S. Post-translational oxidative modification of B2-glycoprotein I and its role in 27 the pathophysiology of the antiphospholipid syndrome. Autoimmun Rev. 2012;11(11):779-80. Erkan D, Lockshin MD; APS ACTION members. (Krillis S) APS ACTION--AntiPhospholipid Syndrome Alliance for Clinical Trials and International Networking. Lupus. 2012 Jun;21(7):695-8. Conway DP, Healey LM, Rauwendaal E, Templeton DJ, Davies SC. Providing HIV negative results to low-risk clients by telephone. Sexual Health. 2012, 9(2): 160-165. 2013 Giannakopoulos B, Krilis SA. The pathogenesis of the antiphospholipid syndrome. N Engl J Med. 2013 Mar 14;368(11):1033-44. Yong A, Pennings G, Wong C, Javadzadegan A, Brieger D, Lowe H, Qi M, Behnia M, Krilis S, Kritharides L. Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease. Int J Cardiol. 2013 Jul 1;166(3):716-21. Lusk MJ, Uddin RNN, Lahra MM, Garden FL, Kundu RL, Konecny P. Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Prevalence in Urban Australian Heterosexuals?,” Journal of Sexually Transmitted Diseases 2013: Article ID 967471 5 pages. Wierema J, Konecny P, Links M. Implementation of risk stratified antibiotic therapy for neutropenic fever: what are the risks? Internal Medicine Journal 2013:43(10): 1116–1124. Bourne C, Allen D, Brown K, Davies SC, McNulty A, Smith DE, O’Connor CC, Couldwell D, Jackson E, Bolton M, Rodgers C, Konecny P, Smith DJ, Parker A. What proportion of sexually transmissible infections and HIV are diagnosed in New South Wales’ public sexual health services compared with other services? Sexual Health 2013; 10(3):290. Prabhu A, Taylor P, Konecny P, Brown M. Pyelonephritis: What are the present day causative organisms and antibiotic susceptibilities? Nephrology 2013;18:463–467. Xu Y, Weatherall C, Bailey M, Alcantara S, De Rose R, Estaquier J, Wilson K, Suuzuki K, Corbeil J, Coo[per DA, Kent SJ, Kelleher AD, Zaunders J. Simian immunodeficiency virus infects follicular helper CD4+ Tcell T cells in lymphoid tissues during pathogenic infection of pigtail macaques. J Virol 2013 Apr; 87(7):3760-73. Lusk MJ, Uddin RNN, Lahra MM, Garden FL, Kundu RL and Konecny P. Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Prevalence in Urban Australian Heterosexuals? Journal of Sexually Transmitted Diseases. Volume 2013;1-5. 28 Bavinton BR, Brown G, Hurley M, Bradley J, Keen P, Conway DP, Guy R, Grulich AE, Prestage G. Which gay men would increase their frequency of HIV testing with home self-testing? AIDS and Behavior. 2013:1-9. Other Published Material 2012 Conway D, Holt M, Atkinson M, Marshall L, McCloskey J, Langdon P, Callander D, Guy R. The Western Australia Sexual Health Service (WASHS) Project: A review of sexual health services for gay, bisexual and other men who have sex with men in Western Australia. Survey report July 2013. The Kirby Institute, Sydney. Presentations at Scientific Meetings and Conferences 2012 - International Krillis S. Invited speaker. The role of oxidation in induction of autoantibodies to Beta 2GPI in patients with the Antiphospholipid syndrome. Autoimmunity Workshop. Athens, Greece. July. Krillis S. Invited speaker. Management of thrombosis in the Antiphospholipid syndrome. Excellence in Rheumatology. Madrid, Spain. 25-January. Krillis S, Chairperson. Antiphospholipid syndrome. Madrid, Spain. January. Krillis S. Invited participant. FXI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in Antiphospholipid syndrome thrombosis. Haemostasis. Gordon Research Conference. Water Valley, New Hampshire, USA. July. Krillis S. Recent developments in the pathogenesis of Antiphospholipid syndrome. Autoimmunity symposium University of Athens, Athens, Greece, September. Krillis S. Invited speaker. The role of oxidative modification of Beta 2GPI induction of autoantibodies in the Antiphospholipid syndrome. Department of Rheumatology, Clinical Immunology Series, Beth Israel Hospital, Harvard Medical School, USA, October. 2012 - National Krillis S. Invited speaker. The role of mast cells in innate immunity. 3rd Australasian Wound and tissue Repair Society and 9th Australasian Society for Dermatology Research. National conference. Sydney, May. Krillis S. Session Chair – Autoimmunity and Allergy. 3rd Australasian Wound and Tissue Repair Society and 9th Australian Society for Dermatology Research, May. Conway DP, Guy R, Davies SC, Couldwell DL, McNulty A, Smith DE, Cunningham P, Keen P, Holt M. Rapid HIV testing is acceptable and preferred among gay men attending sexual health clinics: findings from the Sydney rapid testing study (Oral). Australasian HIV/AIDS Conference, Melbourne 17-19 October. Conway DP, Holt M, McNulty A, Couldwell DL, Smith DE, Davies SC, Cunningham P, Keen P, Guy R. Operational performance of the Determine HIV Combo rapid test when used to test gay and bisexual men for HIV in Sydney sexual health clinics (Oral). Australasian HIV/AIDS Conference, Melbourne 17-19 October. Bavinton B, Conway D, Keen P, Guy R, Prestage G. Which gay men would use home HIV testing (Oral)? Australasian HIV/AIDS Conference, Melbourne 17-19 October. Causer LM, Kuramop M, Karapanagiotidis T, Ryan C, Wand H, Conway D, Denham I, Anderson D, Robertson P, Leslie D, Donovan B, Fairley C, Kaldor J, Guy R. Laboratory evaluation of five point-of-care tests for the diagnosis of syphilis (Oral). 13th International Union against Sexually Transmitted Infections (IUSTI) World Congress, Melbourne 15-17 October 2012. 2013 - International Krillis S. Invited Speaker . Posttranslational forms of B2GPI in diabetic complications. 2013 International Diabetes Summit Forum, Tianjin, China. Krillis S. Invited speaker and member of organising committee 1. Post-translational modification of B2GPI in the antiphospholipid syndrome: implications for autoantibody formation, 2. Chairman; treatment of thrombosis in the antiphospholipid syndrome. XIV International Congress on Antiphospholipid Antibodies, Rio De Janeiro, Brazil, October. Krillis S. Invited speaker. The role of oxidation of complement control proteins in human inflammation. Brigham and Women’s Hospital, Harvard Medical School Seminar Programme, Boston, USA, July. Krillis S. Invited speaker. The role of oxidative posttranslational modification of B2GPI in patients with the antiphospholipid syndrome. Seminar Programme Rockefeller University, July. Krillis S. Invited speaker. Diagnostic tests in the antiphospholipid syndrome: post-translational forms of B2GPI using novel ELISAs. Instrumentation Laboratories the Werfen Group. Boston, USA, May. Konecny P,. Adhikari SA, Choo L K V, Patil M, Duflou J, McWhinney B, Pretorius C, Weatherall C.J. Parenteral Ivermectin Pharmacology in Strongyloidiasis: Postmortem Analysis (Oral). 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Denver, Sept 10-13. Conway DP, Holt M, McNulty A, Couldwell DL, Smith DE, Davies SC, Cunningham P, Keen P, Guy R on behalf of the Sydney Rapid HIV Test study. Field performance of the Alere Determine HIV Combo assay in a large Australian multi-centre study in a sexual health clinic setting. STI & AIDS World Congress 2013, Vienna July 14-17. Conway DP, Guy R, McNulty A, Couldwell DL, Davies SC, Smith DE, Keen P, Cunningham P, Holt M. Experience of rapid HIV testing increases its acceptability to clinical staff in public sexual health clinics in Sydney (Poster). STI & AIDS World Congress 2013, Vienna July 14-17. 2013 - National Conway DP. Rapid HIV Testing in Australia (Oral - invited speaker). Australasian HIV/AIDS Conference, Darwin 21-23 October. Conway DP, Holt M, McNulty A, Couldwell DL, Smith DE, Davies SC, Cunningham P, Keen P, Guy R. Field performance of the Alere Determine HIV Combo assay in recent HIV infection and overall in the Sydney Rapid HIV Test Study (Oral). Australasian HIV/AIDS Conference, Darwin 21-23 October 2013. Conway DP, Guy R, McNulty A, Couldwell DL, Davies SC, Smith DE, Keen P, Cunningham P, Holt M. Effect of testing experience and profession on staff acceptability of rapid HIV testing in public sexual health clinics in Sydney (Oral). Australasian HIV/AIDS Conference, Darwin 21-23 October 2013. Conway DP, Guy R, Atkinson M, Marshall L, McCloskey J, Langdon P, Callander D, Jamil MS, Holt M. Clients at M Clinic, a novel community/peer-worker based clinical service targeting gay and bisexual men, prefer nontraditional methods for HIV/STI testing and result delivery (Poster). Australasian Sexual Health Conference, Darwin 23-25 October 2013. Cunningham PH, Leeman C, Cornwall J, Conway D, Guy R, Kelleher AD. Sensitivity evaluation of six rapid tests for detection of Human Immunodeficiency Virus Infection (Oral). Australasian HIV/AIDS Conference, Darwin 21-23 October 2013. Couldwell D, Biggs K, Townsend J, Conway D, Keen P, Holt M, Guy R. Reasons why men decline rapid HIV testing (Poster). Australasian HIV/AIDS Conference, Darwin 21-23 October 2013.t Robinson S. and Weatherall, C. Poster Presentation, “Eviplera: a case or two for switching” abstract presented at 2013 Australasian HIV conference, Darwin. 29 Awards NSW Health Awards 2013 Annual NSW Health Innovation Award for Integrated Health Care: “Bug Attack - St George Hospital Fight Back: Confronting Resistance” Antimicrobial Stewardship Team 2008-2012, Department Infectious Diseases, Immunology & Sexual Health. 2013 NSW Minister’s Award for Doctors-in-Training Winner: Advanced Trainee Infectious Diseases, Dr Catherine Berry , Department Infectious Diseases, Immunology & Sexual Health. 30 > Department of Intensive Care, St George Hospital Head of Department A/Prof Theresa Jacques MBBS (Hons) FANZCA FCICM MHL, Director, Department of Intensive Care, Conjoint Associate Professor University of New South Wales, Donation Specialist -Medical DONATE LIFE NSW Senior Medical Dr Kush Deshpande MBBS, MD, FCICM, Deputy Director, Department of Intensive Care Unit, Senior Staff Specialist , Conjoint Lecturer, St George Clinical School, UNSW Professor John Myburgh MBBCh PhD FANZCA FCICM FAICD (Head of Research (Program), Professor of Critical Care Medicine, University of New South Wales, Director, Division of Critical Care & Trauma, George Institute for Global Health, Honorary Professor, University of Sydney, Honorary Adjunct Professor, Monash University A/Professor George Skowronski MMBS (Hons), FRCP,FRACP, FCICM, Conjoint Associate Professor, Critical Care, UNSW A/ Prof Konstantin Yastrebrov MBBS (Hons) PhD FCICM FACRRM DDU , Conjoint Associate Professor University of NSW, Senior Honorary Fellow, The University of Melbourne. Dr Doris Lam FCICM, FANZCA, MBChB, Conjoint Lecturer, St George Clinical School, UNSW Dr Manoj Saxena MRCP, FRACP, F.J.F.I.C.M, F.C.I.C.M, M.B. B. Chir, Bsc (Hons) (Deputy to Head of Research Program), Conjoint Lecturer, St George Clinical School, UNSW Dr Andrew Cheng BHB, MBChB (NZ), FCICM, Hospital Medical Director – Organ and Tissue, Conjoint Lecturer, St George Clinical School, UNSW, Director Organ and Tissue 2012, Donation Specialist -Medical DONATE LIFE NSW Dr Carton Costello MB BCH BAO, FCICM, FACRRM, FRACGP, BA Com, Grad Dip Crit Care Echo, Donation Specialist – Medical DONATE LIFE NSW , Director Organ and Tissue 2013, Conjoint Appointee, USNW Visiting Medical Officers Dr Asako Ito B Med, FCICM Dr Atul Gaur MBBS, MD, FRCA, FCICM Dr Barbara Trytko, BMBS, FANZCA, FFICANZA, FCICM Dr Monique Leijten, MD, EDIC FCICM Dr Marek Nalos, MBBS, PhD, EDIC, FCICM Dr Mathew Macpartlin, MBBS, MRCPI, FACEM, FCICM Dr Nhi Nguyen MBBS, B Med Sc, FCICM Dr Paris Jain MBBS, MD, EDIC, FCICM Dr Razavian Maziar, MBBS, FCICM Junior Medical Officers - Senior Registrars Dr Kiran Deol MBBS Dr.Mahadev Patil Dr Menaka Perumbuli Achchige MBBS, MD Anaesthesia Dr Rosalba Cross Dr Raju Pusapati Dr Swapnil Pawar MBBS, MD Dr Syed Ali MBBS,MD Dr.Tejo Kapalli MBBS, MD, FCICM Research Staff Saxena MK PhD Candidate Hammond N PhD Candidate Nair P PhD Candidate Willenberg L MPhil Research Liu A MBBS BSc (Medicine) Bass F MPhil Candidate Liang S MBBS Candidate Miller J Graduate Certificate in in Clinical Research Research Assistants Deborah Inskip, BSc, Grad Cert Crit Care, CNS, Quality, Education, Research and Information Officer, Research Coordinator Jennene Miller, BSc, Grad Cert Crit Care, Grad Cert Clin Research, CNS, Research Coordinator Rebecca Sidoli, Dip Apl Sc, ICU Cert, CNS, Quality, Education, Research and Information Officer Amy Liu, B.Sc. (1st Class Honours), University of NSW Medical Student 2012 Sophie Liang, University of Sydney Medical Student 2013 Nursing & Allied Health Sarah Jones RN, Grad Cert ICU, Grad Dip Education, CNC Suman Adhikari, Bpharm, Grad Dip Clin Pharm ICU Pharmacist Wendy Chaseling B.App.Sc. (physio), M.Ed. M.Hth.Sc (physio) M.A.P.A. APA Cardiorespiratory Physiotherapist, Senior ICU Physiotherapist 31 Theodora Bikou BSW Senior Social Worker ICU Dallas Nolan BSW Social Worker ICU2 Warren Eather, Clinical Data Manager Kylie Fraser. BappSc OT, Manager St George Clinical Skills Centre. Intensive Care Foundation, Vitamin D dosing study in intensive care unit patients with the systemic inflammatory response syndrome, Principal Investigators: Nair P, Venkatesh B, Center J, Myburgh J.A, Krishnan A. $29 000; 2013-2014. Research Grants Nursing & Midwifery Strategy Funding, Study of Communication Practices I ICU, Principal Investigators: S Jones, J Bothe, $9000. NHMRC, A randomised controlled trial of prophylactic hypothermia in severe traumatic brain injury (POLAR trial) (Project Grant: 545901) Principal Investigators: Cooper D.J. Bernard S, Nichol A., Presneill J, Cameron P, Myburgh JA, $1.95M; 2009-2013. NHMRC, The Crystalloid vs Hydroxyethyl starch Trial. (CHEST) (Project Grant: 632503) Principal Investigators: Myburgh J.A. Finfer S.R, Bellomo R, Lipman J, Webb S.R, Liu B. $2.1M; 2010-2014. NHMRC, National Centre for Intensive Care research (Enabling grant extension: 606978) Principal Investigators: Bellomo R, Myburgh J.A. Finfer SR, Cooper DJ, $2.5M; 2010-2015. NHMRC, A phase IIB randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients (BLING) (Project Grant: 1022460) Principal Investigators: Lipman J, Webb S, Dulhunty J, Paterson D, Roberts J, Myburgh J.A. (Associate Investigator) $915 978; 20122017. NHMRC, Practitioner Fellowship (1020204) Principal Investigator: Myburgh J.A. $374 220; 2012-2016. Honda Corporation to St George Medical Research Foundation, The Honda Foundation Trauma and Critical Care Research Program, Principal Investigators: Myburgh J.A, Langcake M, Curtis K, Saxena M. $150 000; 20112013. Fresenius Kabi to University of Sydney / The George Institute for Global Health, The Crystalloid vs Hydroxyethyl starch Trial. (CHEST), Principal Investigators: Myburgh J.A., MacMahon S. $7.6M; 2008-2012. Health Research Council of New Zealand, A placebocontrolled trial of paracetamol in febrile patients with severe sepsis. (HEAT study). Principal Investigators: Beasley R, Young P, McGuinness S, Freebairn R, Van Haren F, Henderson S, McArthur C, Bellomo R, Myburgh J.A, Saxena M, Webb S, Weatherall M. NZ$1.2M; 2012-2014. Health Research Council of New Zealand, Randomised trial of hydrocortisone in critically ill patients with septic shock (ADRENAL) Principal Investigators: McArthur C, Venkatesh B, Young P, McGuinness S, Williams A, Freebairn R, Henderson S, Finfer S, Myburgh J.A. NZ$773 854; 20122016 Research Projects in Progress A retrospective audit of practice of Total Parenteral Nutrition (TPN) at a major teaching hospital in Australia. Principal Investigators: Patil M, Macintrich I, Scoolbread E, Wilson V, Deshpande K. ADRENAL, (Adjunctive corticosteroid treatment in critically ill patients with septic shock. Principal Investigators: Myburgh J Saxena M.K. Intensive Care Foundation The ANZICS Clinical Trials Group Point Prevalence Program, Principal Investigators: Seppelt I, Webb S, McArthur C, Elliot R, Myburgh JA, Glass P, Taylor C. $31 000; 2012. Antimicrobial Stewardship in Intensive Care Unit: Is it possible to demonstrate achievement of all Primary Goals? Principal Investigators: Adhikari S, Konecny P, Taylor P, Piza M, Lam D, Deshpande K. Australian and New Zealand College of Anaesthetists. An exploratory study of perceived risks, benefits and barriers to the use of Selective Decontamination of the Digestive Tract in Australasian ICUs (SuDDICU), Principal Investigators: Seppelt I, Marshall A, Myburgh JA, Lipman J, Francis G, Cuthbertson B, Glass P. $40 000; 2012-2013. BLING ll, (Beta-Lactam Infusion Group), Principal Investigators: Cheng A, Saxena M.K, Adhikari S Intensive Care Foundation, A randomised placebocontrolled trial of intravenous paracetamol in febrile patients (HEAT Study), Principal Investigators: Beasley R, McGuiness S, Freebairn R, Van Haren F, McArthur C, Bellomo R, Myburgh J.A, Saxena M, Webb S, Weatherall M, Henderson S. $20 000; 2013-2014. Characteristics and predictors of mortality in elderly patients (≥ 85 years) admitted to a tertiary ICU in Australia, Principal Investigators: Kapalli T, Deshpande K. 32 CELCIUS, (Comparison of core and peripheral temperature measurement in adult critically ill patients with brain injury). Principal investigators: Liu A, Saxena M.K, Myburgh J, Miller J, Inskip D. COMFORT – Communication with families regarding Organ and Tissue Donation after Death in ICU, Principal Investigatosr: A Cheng A, Costello C. CHEST, (Crystalloid versus Hydyroxyethyl Starch Trial), Principal investigators: Myburgh J.A, Saxena M.K. Topic: Early temperature elevation and functional survival at 24 months after traumatic brain injury: Retrospective analysis of the multi-centre cohort of the SAFE trial. , Principal investigatosr: Liang S, Saxena M.K, Finfer S, Billot L, Myburgh J.A HEAT, (Permissive Hyperthermia Through Avoidance of Paracetamol in Known or Suspected Infection in ICU Principal Investigators: (Co-Chief Investigator - Saxena M.K), Myburgh J.A Family Satisfaction Survey, Principal Investigators: Achchige M, Deshpande K, Jacques T, Bikou T, Nolan D. Nephro Protective Trial, (Nephroprotective effects of L amino acids in critically ill patients), Principal investigator: Jacques T. PARITY, (The Paracetamol after Traumatic Brain Injury study), Principal investigators: Saxena M.K, Taylor C, Myburgh J.A. Glass P, Gowardman J, Lipman J. Sodium Balance Study, Principal Investigators: Saxena M.K, Miller J, Inskip D. Study of Communication Practices in ICU, Principal Investigators: S Jones, J Bothe. TEAM, (Trial of Early Activity and Mobilisation), Principal Investigators: Saxena M.K. Chaseling W. The SANITY Survey - A Survey of Temperature Management After Traumatic Brain Injury - Evaluating the Potential Role of NSAIDs. Principal Investigators: Deol K, Saxena M.K, Myburgh J.A. TTM, (Target Temperature Management after Cardiac Arrest Trial), Principal investigators: Saxena M.K, Myburgh J.A. TRANSFUSE, (Standard Issue Transfusion versus Fresher Red Blood cells use in Intensive Care), Principal Investigators: Deshpande K, Saxena M.K. Original Peer-Reviewed Publications 2012 Cheung W., Myburgh J.A., Seppelt I., Parr M.J., Blackwell N., DeMonte S., Ghandi K., Hoyling L., Nair P., Passer M., Reynolds C., Saunders N.M., Saxena M.K., Thanakrishnan G for the Influenza Pandemic ICU Triage Study Investigators. Development and evaluation of an influenza pandemic ICU triage protocol. Critical Care and Resuscitation, 2012; 14:185-189. Cheung W., Myburgh J.A., Seppelt I., Parr M.J., Blackwell N., DeMonte S., Ghandi K., Hoyling L., Nair P., Passer M., Reynolds C., Saunders N.M., Saxena M.K., Thanakrishnan G for the Influenza Pandemic ICU Triage Study Investigators. A multicentred evaluation of two Intensive Care Unit triage protocols for use in an influenza pandemic. Medical Journal of Australia, 2012; 197: 178181. Dulhunty J., Roberts J., Davis J., Webb S., Bellomo R., Gomersall C., Shirwadkar C., Eastwood G., Myburgh J.A., Paterson D., Lipman J. (2013). Continuous infusion of betalactam antibiotics in severe sepsis: a multicentre, doubleblind, randomised controlled trial. Clinical Infectious Diseases 56: 236-244. Gattas D., Dan A., Myburgh J.A., Lo S., Billot L., Finfer S for the CHEST Management Committee. Fluid resuscitation with 6% Hydroxyethyl starch (130/0.4) in acutely ill patients – an updated systematic review and meta-analysis. Anaesthesia and Analgesia, 2012; 114: 159169. Myburgh J.A., Li Q., Heritier S., Dan A., Glass P for the Crystalloid versus Hydroxy-Ethyl Starch Trial Management Committee. ‘Statistical analysis plan for the Crystalloid versus Hydroxy-Ethyl Starch Trial. Critical Care and Resuscitation, 2012; 14: 44-52. Myburgh J.A. (2012). The role of hydroxyethyl starch for resuscitation in the ICU. Critical Care and Resuscitation, 2012; 14:251 (Editorial). Peake S., Chapman M., Davies A., Moran J., O’Connor S., Ridley E., Williams P for the George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group. (Myburgh J.A.: Principal Investigator: St George Hospital; Management Committee Point Prevalence Program). Enteral nutrition in Australian and New Zealand Intensive Care Units: a point prevalence study of prescription practices. Critical Care and Resuscitation, 2012; 14:158-153. Skowronski GA, Peisah C. The greying intensivist: ageing and medical practice - everyone’s problem. Med J Aust. 2012 May 7;196 (8):505-7. The RENAL Study Investigators. (Myburgh J.A.: Member Writing Committee). Fluid balance and patient outcomes in the Randomised Evaluation of Normal vs Augmented Level of renal replacement therapy trial. Critical Care Medicine, 2012; 40: 1753-1760. Taylor C., Jan S., Curtis K., Tzannes A., Li Q., Palmer C., Dickson C., Myburgh J.A. The cost-effectiveness of physician-staffed hospital emergency medical service (HEMS) transport to a major trauma centre in NSW, Australia. Injury, 2012; 43: 1843-1849. Taylor C., Jan S., Myburgh J.A. Exploring the economics of helicopter rescue in Australia. Medical Journal of Australia, 2012; 197: 488-490. 33 Taylor C., Liu B., Bruce E., Burns B., Jan S., Myburgh J.A, Primary scene responses by Helicopter Emergency Medical Services in New South Wales, Australia 20082009. BMC Health Services Research, 2012; 12:402 St George Hospital). Sodium administration in critically ill patients in Australia and New Zealand: a multicentre point prevalence study. Critical Care and Resuscitation, 2013; 15: 294-300. Willenberg L., Curtis K., Taylor C., Jan S., Glass P., Myburgh J.A. Variation of acute treatment costs of trauma in high-income countries. BMC Health Services, 2012; 12: 267. Bradford C., Finfer S., O’Connor A., Yarad E., Firth R., McCallister R., Harrington T., Steinfort B., Faulder K., Assaad N., Morgan M. (Myburgh J.A.: Chair: Data Monitoring Committee). A randomised-controlled trial of induced hypermagnesaemia following aneurysmal subarachnoid haemorrhage. Critical Care and Resuscitation, 2013; 15: 119-125. Yastrebov K, Sader M, Youssef G, et al. Dynamic Echocardiography in Evaluation of Platypnea-Orthodeoxia. AJUM: 2012 May 15(2)72-76. Young P., Hodgson C., Dulhunty J., Saxena M., Bailey M., Bellomo R., Davies A., Finfer S., Kruger P., Lipman J., Myburgh J.A., Peake S., Seppelt I., Streat S., Tate R., Webb S for the ANZICS Clinical Trials Group. Endpoints for phase II trials in intensive care: recommendations from the Australian and New Zealand Intensive Care Society Clinical Trials Group consensus panel meeting. Critical Care and Resuscitation, 2012; 14:211-215. Young P., Saxena M., Beasley R., Bellomo R., Bailey M., Pilcher D., Finfer S., Harrison D., Myburgh J.A., Rowan K. Early peak temperature and mortality in critically ill patients with and without infection. Intensive Care Medicine, 2012; 38: 437-444. Young P., Saxena M., Andrews L., Bellomo R., Freebairn R., Henderson S., McArthur C., McGuinness S., Mackle D., Myburgh J.A., Van Haren F., Weatherall M., Webb S., Beasley R and the ANZICS Clinical Trials Group. The HEAT trial: a protocol for a phase IIb multi-centre randomised placebo-controlled trial of intravenous paracetamol in intensive care patients with fever and infection. Critical Care and Resuscitation, 2012; 14:290-296 [Correction: Critical Care and Resuscitation 2013: 15: 133]. 2013 Barker CL, Costello C, Clarke PT. Obstetric Air Medical Retrievals in the Australian Outback. Air Medical Journal 2013, 32(6): 329-33. Bellomo R., Lipscey M., Calzavacca P., Haase M., HaaseFelitz A., Licari E., Cole L., Cass A., Finfer S., Gallagher M., Lee J., Lo S., McArthur C., McGuiness S., Myburgh J.A., Scheinkestel C for the RENAL Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis. Intensive Care Medicine, 2013; 39: 429-326. Bihari S., Peake S., Seppelt I., Williams P., Bersten A., on behalf of the George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group. (Myburgh J.A.: Principal Investigator, 34 Cooper D.J., Myburgh J.A., Bellomo R., Billot L., Finfer S., Heritier S., Murray L., Vallance S., for the SAFETBI Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Albumin resuscitation for traumatic brain injury – is intracranial hypertension the cause of increased mortality? Journal of Neurotrauma, 2013; 30: 512-518. Dulhunty J., Roberts J., Davis J., Webb S., Bellomo R., Gomersall C., Shirwadkar C., Eastwood G., Myburgh J.A., Paterson D., Starr T., Udy A., Paul S., Lipman J and the Australian and New Zealand Intensive Care Society Clinical Trials Group and Australasian Society for Infectious Diseases Clinical Research Network. A protocol for a multicentre randomised-controlled trial of continuous beta-lactam infusion compared with intermittent betalactam dosing in critically ill patients with severe sepsis: the BLING II study. Critical Care and Resuscitation, 2013; 15:179-185. Gattas D., Dan A., Myburgh J.A., Billot L., Lo S., Finfer S., for the CHEST Management Committee. Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Medicine, 2013; 39: 558-568. Hammond N., Saxena M., Taylor C., Young P., Seppelt I., Glass P., Myburgh J.A., for the George Institute for Global Health and ANZICS Clinical Trials Group. Temperature management of non-elective intensive care patients without neurological pathology: a point prevalence study of practice in Australia and New Zealand. Critical Care and Resuscitation, 2013; 15:228-233. Myburgh J.A., Finfer S. Causes of death after bolus fluid resuscitation: new insights from FEAST. BMC Medicine, 2013; 11:67 (Editorial). Myburgh J.A., McIntyre L. New insights in fluid resuscitation. Intensive Care Medicine, 2013; 39: 998-1001 (Editorial). Myburgh J.A. Advances in fluid resuscitation in critically ill patients: implications for clinical practice. Current Opinion in Critical Care, 2013; 19: 278-291 (Editorial). Myburgh J.A. Review: Hydroxyethyl starch increases mortality and acute kidney injury in critically ill patients. Annals of Internal Medicine, 2013; 158: JC4. Nair P., Center J., Eisman J., Nguyen N., Myburgh J.A., Cylee P., Reynolds C. Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Medicine, 2013; 39: 267-274. Nielsen N., Wetterslev J., Cronberg T., Erlinge D., Gasche Y., Hassager C., Horn J., Hovdenes J., Kjaegaard J., Kuiper M., Pellis T., Stammet P., Wanscher M., Wise M., Aneman A., Al-Subaie N., Boesgaard S., Bro-Jeppsen J., Brunetti I., Bugge J., Hingston C., Juffermans N., Koopmans M., Kober L., Langorgen J., Lilja G., Moller J., Rundgren M., Rylander C., Smid O., Werer C., Winkel P., Friberg H for the TTM investigators. (Myburgh J.A.: Study Director, George Institute for Global Health, Saxena M: Site PI ). Targeted temperature management at 33oC versus 36oC after cardiac arrest. New England Journal of Medicine, 2013; (Published online 17 November 2013). Parke R., Eastwood G., McGuinness on behalf of the George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group. (Myburgh J.A.: Principal Investigator). Oxygen therapy in non-intubated adult intensive care patients: a point prevalence study.’ Critical Care and Resuscitation, 2013; 15: 287-293. Saxena M.K. Taylor C., Hammond N., Young P., Seppelt I., Glass P., Myburgh J.A. for the George Institute for Global Health and the ANZICS Clinical Trials Group. Temperature management in patients with acute neurological lesions: an Australian and New Zealand point prevalence study. Critical Care and Resuscitation, 2013; 15: 110-118. Venkatesh B., Myburgh J.A., Finfer S., Webb S., Cohen J., Bellomo R., McArthur C., Joyce C., Rajbhandari D., Glass P., Harward M and the ANZICS Clinical Trials Group Investigators. The ADRENAL Study protocol: Adjunctive corticosteroid tREatment iN criticAlly iLl patients with septic shock. Critical Care and Resuscitation, 2013; 15: 83-87. Yastrebov K, McLean A: Establishment of Critical Care Echocardiography Laboratory. Crit Care 2013; 17 Sup2, S69, P184. Yastrebov K, Kapalli T: Malposition of Double Lumen Bicaval Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) cannula resulting in hepatic venous congestion. AJUM, November 2013. Young P., Weatherall M., Saxena M., Bellomo R., Freebairn R., Hammond N., Van Haren F., Henderson S., McArthur C., McGuinness S., Mackle D., Myburgh J.A., Webb S., Beasley R and the ANZICS Clinical Trials Group. The statistical analysis plan for the HEAT trial: a multi-centre randomised placebo-controlled trial of intravenous paracetamol in intensive care patients with fever and infection. Critical Care and Resuscitation, 2013; 15:279286 Other Published Material 2012 Douglas B, Morarty J, Saxena M K (2012) Traumatic Brain Injury In: Emergency and Trauma Care for nurses and paramedics. (Curtis K, Ramsden C). Sydney: Mosby Elsevier. pp 1169-1192. 2013 Gordon A., Myburgh J.A. (2013). Vasodilators and antihypertensives. In: Oh’s Intensive Care Manual 7th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. pp. 923-936. Myburgh J.A., Saxena M.K. (2013). Severe Head Injury. In: Oh’s Intensive Care Manual 7th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. pp. 762-776. Myburgh J.A. (2013). Inotropes and vasopressors. In: Oh’s Intensive Care Manual 7th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Elsevier. pp. 912922. Skowronski G. Saxena M. (2013). Neuromuscular Disorders. In: Oh’s Intensive Care Manual 7th edition. (Bersten A.D., Soni N. eds). London: Butterworth Heinemann Chapter 57. Presentations at Scientific Meetings and Conferences 2012 - International Gallagher M., Bellomo R., Cass A., Gattas D., Lee J., Lo S., McGuinness S., Myburgh J.A., Parke R. October 2012 (San Diego, USA). Long term outcome of severe AKI: the results of the POST-RENAL study. American Society of Nephrology: Kidney Week 2012. Hammond N., Saxena M.K. Young P., Taylor C., Seppelt I., Glass P., Myburgh J.A. Temperature management for patients without brain injury in Australia and New Zealand Intensive Care Units: a point prevalence survey. A survey of fever management in febrile critically ill patients without neurological injury. 32nd International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium. March. Myburgh J.A. The case for randomised-controlled trials for fluid resuscitation. Round Table Conference: International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March. 35 Myburgh J.A. Report of the Round Table Conference: Types of intravenous fluids. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March. Care Forum. Toronto, Canada, November. Yastrebov K. Visiting Professor in Intensive Care, Hospital Ambroise Pare. Paris, France, June. Myburgh J.A. The CHEST study. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March. Willenberg L., Curtis K., Taylor C., Jan S., Glass P., Myburgh J.A. Variation of acute treatment costs of trauma in high-income countries. London Trauma Conference. London, UK, November. Myburgh J.A. I believe in adrenaline. International Symposium on Intensive Care and Emergency Medicine. 2012 - National Myburgh J.A. The Crystalloid vs Hydroxyethyl Starch Trial. 11th Congress in Evidence Based Perioperative Medicine and the Great World Fluid Debate. London, UK July. Myburgh J.A. Unanswered questions in fluid management. 11th Congress in Evidence Based Perioperative Medicine and the Great World Fluid Debate. London, UK July. Myburgh J.A. Fluid resuscitation with 6% HES (130/0.4)/ vs normal saline: The CHEST trial. Hot topics session: European Society of Intensive Care Medicine Annual Scientific Meeting. Lisbon, Portugal, October. Gallagher M., Bellomo R., Cass A., Finfer S., Gattas D., Lee J., Lo S., McGuinness S., Myburgh J.A., Parke R., Rajbhandari D. Long term outcome of severe AKI: the results of the POST-RENAL study. Australian and New Zealand Society of Nephrology Annual Scientific Meeting. Melbourne, August. Ito A., Lam D., Deshpande K. Bacteraemia in Intensive Care Unit: Temporal trends in epidemiology and antimicrobial susceptibility. College of Intensive Care Medicine Annual Scientific Meeting. Melbourne, June. Myburgh J.A. The CHEST trial. Critical Care Canada Forum. Toronto, Canada, October. Myburgh J.A. Sustainable Intensive Care. Bush Track to Boulevard: College of Intensive Care Medicine Rural and Regional Meeting. Byron Bay, March. Myburgh J.A. Pressors, inotropes and fluids: do our choices really matter? Critical Care Canada Forum Residents’ Day. Toronto, Canada, October. Myburgh J.A. CHEST update. Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Scientific Meeting. Noosa, March. Myburgh J.A. Development of a definitive RCT of steroids in critically ill patients. Critical Care Canada Forum. Toronto, Canada, October. Myburgh J.A. NICE-SUGAR TBI - results. Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Scientific. Noosa, March. Myburgh J.A. Fluid resuscitation in specific patient populations: sepsis and traumatic brain injury. Critical Care Canada Forum. Toronto, Canada, October. Myburgh J.A. The CHEST trial results. Australian and New Zealand Intensive Care Society Clinical Trials Group Winter Research Forum. Melbourne, July. Myburgh J.A. The CHEST trial. International Sepsis Forum. Paris, France, November. Myburgh J.A. A fluid movement in acute medicine. St George Hospital, Malcolm Schonnel Memorial Lecture. Sydney, February. Myburgh J.AType of intravenous fluids. .. Conferences de soins intensifs et de medecine d’urgence: Hopital Erasme. Brussels, Belgium, November. Myburgh J.A. Inotropes and vasopressors. Crit IQ: podcast. May 2012. Myburgh J.A. Resuscitation fluids: past, present, future. University of Birmingham, UK, November. Myburgh J.A. Fluid resuscitation – new developments. Sydney Intensive Care Network, May. Saxena M.K. Young P., Bailey M., Pilcher D., Beasley R., Bellomo R., Finfer S., Myburgh J.A. Early peak temperature and mortality in critically ill patients with acute neurological pathology. Canadian Critical Care Forum. Toronto, Canada, November. Saxena M.K. The CLARITY study –Understanding “normothermia” after TBI and stroke. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Meeting Noosa, March. Saxena M.K. Taylor C., Hammond N., Bellapart J., Skirfvars M., Loh A., Nayyar V., O’Leary M., Rajbandhari D., Hardie M., Rashid A., Seppelt I., Glass P., Myburgh J.A. Defining normothermia for traumatic brain injury: and Australian multicentre retrospective cohort study. Canadian Critical 36 Saxena M.K. Normothermia for Acute Neurological Pathology: is a RCT feasible / CLARITY Update. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Meeting Adelaide, October. Saxena M.K. Normothermia and Acute Brain Injury. Nepean Hospital: Intensive Care Seminar. Sydney, April. Saxena M.K. Establishing Early Medical Consensus … St. George Hospital: Medical Morbidity and Mortality Meeting Sydney, May. Saxena M.K. Normothermia and Acute Brain Injury. St Vincent’s Hospital: Intensive Care Seminar Sydney, June. Saxena M.K. To Cool or Not to Cool … (Sepsis). St. George and Sutherland Nursing Symposium. Sydney, September. Saxena M.K. Normothermia and Acute Brain Pathology, St George and Sutherland Nursing Symposium. Sydney, September. Saxena M.K. Current Cooling Practices in Intensive Care Normothermia and Acute). St. George and Sutherland Nursing Symposium. Sydney, September. Saxena M.K. The management of Traumatic Brain Injury. Advanced Trauma Nursing Sydney, October. Saxena M.K., Taylor C., Hammond M., Young P., Seppelt I., Glass P., Myburgh J.A. Temperature management after acute brain injury: a point prevalence study of practice in Australia and New Zealand. Australian and New Zealand Intensive Care Society Annual Scientific Meeting. Adelaide, October. Saxena M.K. Taylor C., Hammond N., Bellapart J., Skirfvars M., Loh A., Nayyar V., O’Leary M., Rajbandhari D., Hardie M., Rashid A., Seppelt I., Glass P., Myburgh J.A. Defining normothermia for traumatic brain injury: An Australian multicentre retrospective cohort study. Australian and New Zealand Intensive Care Society Annual Scientific Meeting 2012. Adelaide, October. Yastrebov K. Presenter Advanced course on Critical Care Echocardiography. Leura, NSW, August. 2013 - International Doolan H., Jacques T., Mackertich M., Stirling A., Fernandez R. May 2013, Examining the prevalence and outcomes of patients with signs of documented early deterioration, a comparison of two models. 8th International Rapid Response Conference. Royal College of Physicians, London UK. Hammond N., Taylor C., Liu B., Finfer S., Glass P., Saxena M., Seppelt I., Willenberg L., Myburgh J.A. for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the George Institute for Global Health. May 2013. Fluid resuscitation practices in Australia and New Zealand intensive care units – preliminary data. College of Intensive Care Medicine Annual Scientific Meeting. Wellington, NZ. Hammond N., Taylor C., Liu B., Finfer S., Glass P., Saxena M., Seppelt I., Willenberg L., Myburgh J.A. for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the George Institute for Global Health. October 2013. Fluid resuscitation practices in Australia and New Zealand intensive care units. European Society of Intensive Care Medicine Annual Scientific Meeting. Paris, France. Jacques T. February 2013, Introducing a bended learning programme to front -line staff: Plenary Speaker at the inaugural National Japanese Medical Simulation Meeting Okinawa, Japan. Myburgh J.A. May 2013. Why we need a definitive trial on steroids. Chinese Society of Critical Care Medicine. Xiamen, China. Myburgh J.A. May 2013. Colloids in critical care: an analysis of recent trials. Chinese Society of Critical Care Medicine. Xiamen, China. Myburgh J.A. June 2013. Decompressive craniectomy: never for anything? College of Intensive Care Medicine Annual Scientific Meeting. Wellington, NZ Myburgh J.A. March 2013. Albumin in brain oedema. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. Myburgh J.A. March 2013. PRO: Synthetic colloids should be abandoned. International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium Myburgh J.A. March 2013. Optimal design for clinical trials. International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium. Myburgh J.A. March 2013. The CHEST Trial: further analyses. International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium. Myburgh J.A. July 2013. The evidence for the use of vasopressors in critically ill patients. Singapore-ANZICS Intensive Care Forum. Singapore. Myburgh J.A. July 2013. Hydroxyethyl starch for fluid resuscitation in critically ill patients. Singapore-ANZICS Intensive Care Forum. Singapore. Myburgh J.A. July 2013. The case for a definitive trial of steroids in septic shock. Singapore-ANZICS Intensive Care Forum. Singapore. Myburgh J.A. August 2013. A renal-safe colloid: a pipe dream? 11th World Federation of Intensive and Critical Care Medicine Meeting. Durban, South Africa. Myburgh J.A. August 2013. Should we move away from God’s only inotrope? Adrenaline vs noradrenaline? 11th World Federation of Societies of Intensive and Critical 37 Care Medicine Meeting. Durban, South Africa. Myburgh J.A. August 2013. Adrenaline and noradrenaline and the heart. 11th World Federation of Societies of Intensive and Critical Care Medicine Meeting. Durban, South Africa. Myburgh J.A. August 2013. (Durban, South Africa). The CHEST trial – further questions. 11th World Federation of Societies of Intensive and Critical Care Medicine Meeting. Myburgh J.A. September 2013. Our evolving knowledge of fluid options. Baxter Satellite Meeting: European Society of Intensive Care Medicine Annual Scientific Meeting. Paris, France. Myburgh J.A. September 2013. Commentary: Computerised tight vs. conventional glycaemic control in critically ill patients. President’s sessions: European Society of Intensive Care Medicine Annual Scientific Meeting. Paris, France. Saxena M.K. Taylor C., Hammond N., Bellapart J., Skirfvars M., Loh A., Nayyar V., O’Leary M., Rajbandhari D., Bradford C., Hardie M, Rashid A., Seppelt I., Glass P., Myburgh J.A. March 2013. Defining normothermia for traumatic brain injury: an Australian multicentred retrospective study. 33rd International Symposium on Intensive Care and Emergency Medicine. Brussels Belgium. Saxena M.K. 2013. The CHEST Study. French society of Critical Care Medicine . Paris, France. Saxena M.K. 2013. Future Directions for the Australia and New Zealand Intensive Care Society. French society of Critical Care Medicine. Paris, France. Saxena M.K. 2013. How to understand Controversial Sepsis Studies. French society of Critical Care Medicine. Paris, France. Saxena M.K. 2013 Doctor, please feed me ... I am starving to death. The 2nd Singapore ANZICS Intensive Care Forum, Singapore. Saxena M.K. 2013 Fever for sepsis: better to be hot than cool. The 2nd Singapore ANZICS Intensive Care Forum Singapore, Yastrebov K. March 2013. Establishing Critical Care Echocardiography Laboratory. 33rd International Symposium on Intensive Care. Brussels, Belgium. Adhikari S Antimicrobial Stewardship in Intensive Care Unit: Three year Evaluation of a Multidisciplinary Model. Australian Society of Antimicrobials: Sydney. Jones S Pressure Injury Prevention in the Critically Ill Adult: 2nd Annual Reducing Avoidable Pressure injuries Conference Melbourne. Kapalli T, Deshpande K. Characteristics and predictors of mortality in elderly patients (≥ 85 years) admitted to a tertiary ICU in Australia. College of Intensive Care Medicine Annual Scientific Meeting. Wellington, NZ, June. Liu A., Saxena M.K, Myburgh J.A. The CELSIUS Study. St George and Sutherland Hospitals Medical Symposium. Sydney, October. Myburgh J.A. Further results from the CHEST trial. Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Scientific Meeting. Noosa, March. Myburgh J.A. Fluid resuscitation: which, when and how much? SMACC: Social media and Critical Care. Sydney, March. Myburgh J.A. Catecholamines: resuscitation or resurrection: fact or fiction. SMACC: Social media and Critical Care. Sydney, March. Myburgh J.A. Fluid resuscitation. Royal Prince Alfred Hospital. Sydney, November. Saxena M.K. A protocol for a conservative fluid randomised clinical study. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Meeting. Melbourne, August. Saxena M.K. Core Outcome Measure Sets for Critical Care Trials: a report from the International Sepsis Forum/ International Forum of Acute Care Triallists Colloquium. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Meeting. Melbourne, August. Saxena M.K. Does a conservative fluid strategy compared to “Usual fluid management” improve outcomes for critically ill patients? The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Meeting. Noosa, March. Saxena M.K Current and future fluid trials in resuscitation, Australia and New Zealand Intensive Care Society, Australian College of Critical Care Nurses, Annual Scientific Meeting. Hobart, October. Yastrebov K. March 2013. Instructor: Basic and Advanced Courses on Critical Care Echocardiography. Brussels, Belgium. Saxena M.K. The importance of corporate + philanthropic support in improving the health of patients in Australia and New Zealand. Intensive Care Foundation, Feburary. 2013 - National Seppelt I., Marshall A., Dan A., Cole L., Weisbrodt L., 38 Glass P., Myburgh J.A., Finfer S., Lipman J., Francis J., Cuthbertson B. An international Delphi study examining the perceived risks, benefits and barriers to the use of selective decontamination of the digestive tract (SDD) in intensive care. Australian Society of Infectious Disease Annual Scientific Meeting. Canberra, March. Shiner E, Hersch M, Yastrebov K, Normal CSF in HSV Enchephalitis. Proceedings of the Australian and New Zealand Association of Neurology Annual meeting. Community Engagement Wendy Chaseling Chair ICCMU/ACI - Best Practice Group -Suctioning the Artificial Airway of the Adult ICU patient: A Clinical Practice Guideline A/Prof Theresa Jacques Chair Medical Staff Council St George Hospital Chair Medical Staff Council Executive Council SESLHD Member Clinical Council The St George Hospital Co-Chair ICCIS Workgroup ACI /Ministry of Health Member ANZICS End of Life Care work group Chief Editor DETECT Donation Specialist -Medical DONATE LIFE NSW ICCIS PROJECT http://vimeo.com/ user19020418review/71555501/14629d34f3 Excellence in Clinical Collaboration: The ICCIS Project http://vimeo.com/ user19020418review/91390334/00ca3802e0 Jacques T, Morris R, Fraser K. Debrief for Health Care Professionals involved in DETECT June 2013 Sarah Jones Chair ISCN (Intensive Care Services Network) Best Practice Group Professor John Myburgh Member, Academic Council, St George Clinical School Member: Scientific Advisory Committee, St George Medical Research Foundation President, College of Intensive Care Medicine Practitioner Fellow: National Health and Medical Research Council Council Member, World Federation of Societies of Intensive and Critical Care Medicine Malcolm Schonell Medal, St George Hospital 2012 Honour Roll, Australian and New Zealand Intensive Care Society 2013 St George Clinical School Research Excellence Award, University of New South Wales 2013 International collaborations 1. Round Table Conference: Types of intravenous fluids. International Symposium on Intensive care and Emergency Medicine. (Chairman). Brussels. 2012. 2. Faculty of Intensive Care Medicine, United Kingdom. Board retreat. (Invited international expert). London. 2012. 3. Intracranial pressure monitoring in traumatic brain injury Think Tank: BEST TRIPS collaborative. Seattle. 2013. 4. Acute Dialysis Quality Initiative (ADQI XII): 12th Consensus Conference: Across the oceans in 2013: the fluid debate rages on. London. 2013. 5. Global Fluid Management: Advisory Board Meeting to Baxter Pharmaceuticals. Paris. 2013. National collaborations 1. Clinical Trials Research Summit: The Medical Journal of Australia. Sydney. 2012. 2. Advisory Board to Baxter Pharmaceuticals:Intravenous Fluids. Sydney. 2013 Dr Manoj Saxena Honorary Fellow, Critical Care & Trauma Division, The George Institute for Global Health Chair: Scientific Committee – St. George and Sutherland Medical Research Symposium Committee Member: St. George and Sutherland Medical Research Symposium Executive Committee Member for NSW: Australia and New Zealand Intensive Care Society Clinical Trials Group Examiner: College of Intensive Care Medicine 1. “The CICM Examination Process from the Perspective of an Examiner” a. The Wellington Intensive Care Medicine Course (2012 and 2013) b. The Nepean Hospital Written Examination course (2012) 2. Sydney Long Course in Intensive Care Medicine (2012 and 2013) 3. Sydney Short Course in Intensive Care Medicine (2012 and 2013) 4. Nepean Written Course in Intensive Care Medicine (2013) 39 5. The Trek for Trauma (Kokoda Track, Papua New Guinea, June 2013): St George and Sutherland Medical Research Foundation 6. “A Long Walk Back” (ABC Documentary): (http:// www.abc.net.au/austory/specials/longwalkback/ default.htm) St. George and Sutherland Medical Research Foundation 7. “The importance of corporate + philanthropic support in improving the health of patients in Australia and New Zealand”. Intensive Care Foundation (Sydney, Feb 2013) A/ Prof Konstantin Yastrebrov Member of Steering Committee for Postgraduate Diploma of Echocardiography. Kylie Fraser Clinical Skills Centre Executive Member, Member Editorial Panel DETECT programme. 40 > Department of Nuclear Medicine Head of Department Dr Patrick Butler MA, MD, MBA, FRACP Conjoint Associate Professor UNSW Senior Medical Dr Scott Beuzeville BMed(Hons), FRACP Dr Richard QuinnMBBS, DDU, FRACP Dr Ramy Nour MBBS, FRACP Junior Medical Dr Rosamma Bency MBBS Dr Parameswar Rachumulla MBBS Physicists Dr Erin McKay PhD, MACPSEM Mr Casper Marciniak MSc, MACPSEM Radiochemist Ms Effie Browne BAppSci, MScMed Medical Radiation Scientists Mr Peter McConachie BAppSci, MCom Mr Andrew Cluff BAppSci, MBA Presentations at Scientific Meetings and Conferences 2012 – National McKay E. SPECT Quantitation of Lu-177. ANZSNM Annual Scientific Meeting, Melbourne, April 2012. Browne E, McKay E, Smart RC. Radiation Safety Precautions with 177Lu-Octreotate therapy. ANZSNM Annual Scientific Meeting, Melbourne, April 2012. R Bency, E McKay, D Farlow, Comparison of Ga-68 Dotatate scanning and Lu-177 Dotatate scanning in NET patients undergoing PRRT. ANZSNM Annual Scientific Meeting, Melbourne, April 2012. 2013 – National McKay E. Individual Variation in Renal Dosimetry of Lu-177 Octreotate. ANZSNM Annual Scientific Meeting, Perth, April 2013. Marciniak C, McKay E. Implementation of a Channelised Hotelling Observer. ANZSNM Annual Scientific Meeting, Perth, April 2013. Research Projects in Progress Quantitation of Lu-177 Dotatate uptake in the treatment of neuroendocrine tumours. Principal Investigator: Dr Erin McKay. Reproducibility of isotopic GFR measurements. Principal Investigator: Dr Patrick Butler. 41 > Department of Renal Medicine Head of Department Professor Mark Brown MBBS, MD, FRACP (Professor of Medicine, UNSW) Senior Medical Associate Professor John Kelly MBBS, MD, FRACP Associate Professor George Mangos MBBS, MD, FRACP Associate Professor Ivor Katz MD, MBBCh, FCP(SA), BSc Honours, PhD, FRACP Dr Sharon Ong BSc(Med), MBBS, PhD, FRACP (Conjoint Senior Lecturer, UNSW) Dr William Chan MBBS, PhD, FRACP Dr Parthasarathy Shanmugasundaram MBBS, DM, FRACP (Conjoint Lecturer, UNSW) Dr Cathie Lane B.Pharm. B.Med FRACP,Grad Cert ULT, PhD (Conjoint Lecturer, UNSW) Dr Frank Brennan MBBS, FRACP, FAChPM, LLBConsultant Palliative Care Medicine Research Research Fellow The role of cortisol in the development of hypertension and cardiovascular disease in chronic kidney disease $75 000, 2012. SESLHD Chronic Care Service Redesign Grant, A/Prof Ivor Katz The development of a web-based Chronic Kidney Disease Outreach Program $15 000, 2012. Amgen, Prof Mark Brown Renal Supportive Care: Patient Outcomes and Quality of Life, $74,678, 2012 Amgen Research Grant, A/Prof Ivor Katz The development of a web-based Chronic Kidney Disease Outreach Program, $ 60,000, 2012-2013. Research Projects in Progress Hypertension in chronic kidney disease (CKD) Dr Sharon Ong and A/Prof John Kelly 1. Adequacy of blood pressure control in CKD Dr Franziska Pettit MB BAO Bch BMSc MRCPI FRACP 2. 24 hour ambulatory and self home blood pressure monitoring in CKD Medical Students 3. Role of glucocorticoids in hypertension in CKD Colin Chng Foong Ming Ho CKD health systems research A/Prof Ivor Katz Research Officers 1. 1Achievement of target BP & other risk factors on CKD patients. Saiyini Pirabhahar Paula Williamson Gemma Collett 2. Patterns of referral for CKD Management. Nursing & Allied Health Elizabeth Josland Shelley Tranter Tania Burns Jennifer Beddoe Yanella Matinez-Smith Coralie Meek Maria Chan 3. CKD to kidney failure - predictive model. 4. Web based CKD outreach program. Hypertension in pregnancy Prof Mark Brown and A/Prof George Mangos, A/Prof Greg Davis and A/Prof Tony O’Sullivan) 1. The ‘new’ R-A-A system in pre-eclampsia. 2. Body composition in normal pregnancy. Research Grants 3. Outcomes of hypertensive pregnancies. Clive and Vera Ramaciotti Foundation Research Establishment Grant, Dr Sharon Ong 4. Post-partum physiology, psychology and pediatric outcomes for women with preeclampsia (the ‘P4’ study). 42 Renal palliative care Dr Frank Brennan and Prof Mark Brown 1. The role of palliative care in improving quality of life outcomes for hospital based haemodialysis patients. 2. Quality of life & symptom burden in dialysis patients. 3. Survival and symptom control of patients in Predialysis & Renal Supportive Care clinics.Outcomes of patients in Pre-dialysis & Renal Supportive Care clinics. 4. Retrospective and prospective studies of the effects of a Renal Palliative care service on patients with CKD stage 4/5 and their carers. 5. A study of ‘good deaths’ in dialysis patients. Nutrition in CKD Maria Chan and A/Prof John Kelly 1. Relationship between nutritional status and outcome in end stage kidney disease. Original Peer-Reviewed Publications 2012 Brown MA. Proteinuria in pre-eclamptic pregnancy: does it matter anymore? Nat. Rev Nephrol. 2012; 8:563–565. Brown MA, Roberts LM, Mackenzie C, Mangos G, Davis GK. A Prospective Randomized study of Automated versus mercury blood pressure recordings in hypertensive pregnancy (PRAM study). Hypertension in Pregnancy. 2012;31:107-119. Chan, M., J. Kelly, M. Batterham and L. Tapsell. “Malnutrition (Subjective Global assessment) Scores and Serum Albumin Levels, but not Body Mass Index Values, at Initiation of Dialysis are Independent Predictors of Mortality: A 10-Year Clinical Cohort Study.” Journal of Renal Nutrition 22(6): 547-557, 2012. Chan M. Nutrition, diabetes and chronic kidney disease, Australian Diabetes Educator. Volume 15 Number 3, August 2012, pp17-23. Hawkins L-A, Brown MA, Mangos G, Davis GK. Transient gestational hypertension: not always a benign event. Pregnancy Hypertension. 2012; 2: 22-27. Hawkins TL, Roberts JM, Mangos GJ, Davis GK, Roberts L, Brown MA. Plasma Uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort analysis. British Journal of Obstetrics and Gynaecology 2012; 119:484–492. Head GA, McGrath BP, Mihailidou AS, Nelson MR, Schlaich MP, Stowasser M, Mangoni AA, Cowley D, Brown MA, Ruta LA, Wilson J. Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement. Journal of Hypertension 2012, 30:253–266. Josland E, Brennan F, Anastasiou A, Brown MA. Developing and sustaining a renal supportive care service for people with end stage kidney disease. Renal Society of Australasia Journal 2012; 8(1): 12-18. Mangos GJ, Spaan J, Pirabhahar S, Brown MA. Markers of cardiovascular disease risk after hypertension in pregnancy. Journal of Hypertension 2012, 30:351–358. Moustakas J, Bennett P, Tranter S, Nicholson J. The needs of older people with advanced chronic kidney disease choosing supportive care: a review. Renal Society of Australasia Journal 2012, 8(2) 70-75. Ong SLH, Whitworth JA. Glucocorticoid-induced hypertension and the nitric oxide system. Expert Rev Endocrinol Metab 2012; 7(3): 273-280. Pettit F, Brown MA. The Management of Pre-eclampsia: what we think we know. European Journal of Obstetrics & Gynecology and Reproductive Biology 2012; 160: 6–12. Pianta TJ, Horvath AR, Ellis VM, Leonetti R, Moffat C, Josland EA, Brown MA.Cardiac high-sensitivity Troponin T measurement: a layer of complexity in managing hemodialysis patients. Nephrology. 2012; 17: 636–641. Spaan J, Brown MA. Renin Angiotensin system in preeclampsia: everything old is new again. Obstetric Med.2012;5: 147-153. Spaan J, Peeters L, Spaanderman M, Brown MA. Cardiovascular risk management after a hypertensive disorder of pregnancy. Hypertension 2012;60:1368-1373. Westgarth F, Chiarella M. & Tranter S. The Haemodialysis Models of Care Program. Renal Society of Australasia Journal 2012, 8(1) 24-31. 43 2013 Brennan FP. “Clock without Hands”. American Journal of Hospice and Palliative Medicine 2013; 30(3):312-316. Brennan FP. Conscientious Objector – Edna St Vincent Millay, mortality and the nature of Palliative Care. Journal of Palliative Care 2013; 29(2): 123-125. Brennan FP, Brown M. An ethical approach to dialysis – an alliance of Nephrology, Palliative Medicine and ethics. Quarterly Journal of Medicine 2013; 106(5): 397-400. Brennan FP. The New World of Ourselves. Journal of Palliative Care 2013; 29(4): 258-259. Brennan FP. Ethical Principles for Patients, Families and Doctors to Consider. Nephrology 2013; 18: 413-414. Brennan FP, Siva B, Crail S. Appropriate Assessment of Symptom Burden and Provision of Patient Information. Nephrology 2013; 18: 418-421. Brennan FP. Holistic Palliative Care Approach - Physical, Spiritual, Religious and Psychological Needs. Nephrology 2013;18: 421-423. Brennan FP, Murrell DF. Report from the Inaugural Australian Pruritus Symposium, Sydney, Australia, August 10 2013. Acta Derm Venereol 2013. Oct 24 (Epub ahead of print). Brown MA. Is there a role for ABPM in Pregnancy? Clinical and Experimental Physiology and Pharmacology. 2013. DOI.10.1111/1440-1681.12106. Brown MA, Crail SM, Masterson R, Foote C, Robins J, Katz I, et al. ANZSN Renal Supportive Care Guidelines 2013. Nephrology. 2013;18(6):401-54. Burns, T. Waiting for a kidney transplant in Australia. Transplant Journal of Australasia, 2013b: 23, 10-15. Crail S, Walker R, Brown M. Renal Supportive Care working group. Renal supportive and palliative care: position statement. Nephrology. 2013; 18(6):393-400. Cuesta, C., Blow, T. & Tranter, S. Epidermolysis bullosa:a rare challenge for peritoneal dialysis nurses. Renal Society of Australasia Journal, 2013:9, 41-44. Foo JY, Mangos GJ, Brown MA. Characteristics of hypertensive disorders in twin versus singleton pregnancies. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 2013; 3:3-9. Johnson DW, Atai E, Chan M, Phoon RKS, Scott C, Tussaint N, Turner GI, Usherwood T, and Wiggins, K. KHACARI guideline: Early chronic kidney disease: detection, prevention and management. Nephrology 18 (2013) 340–350. 44 Josland, E. Quality of Life. What information is already available and what evidence is this based on? Nephrology, 2013c: 18, 410-413. Lim CED, Siow S, Ho KEH, Chua JL, Chong N, Cheng L, Kwok, Brennan FP, Cigolini M. Advance Care planning in haemodialysis patients. Protocol Information. Cochrane Reviews. Review number 294. September 2013. Ong SLH, Vohra H, Zhang Y, Whitworth JA. The role of mitochondrial superoxide in glucocorticoid-induced hypertension. Oxid Med Cell Longev 2013; 2013:517045. Pettit F & Ong SLH. Management of Hypertension in Pregnancy. eMIMS Disease Index. Revision August 2013. Prabhu A, Taylor P, Konecny P, Brown MA. Pyelonephritis: What are the present day causative organisms and antibiotic susceptibilities? Nephrology. 2013;18(6):463-7. Siva B, Brennan FP. Inappropriate Interventions in the Dying Patient. Nephrology 2013; 18: 423-424. Spaan J, Bowyer L, Lazzaro V, McCrohon J, Brown MA. Maternal hemodynamics influence fetal hemodynamics in normal and hypertensive pregnancy. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. 2013; 3:10–15. Spaan J, Brown MA. Can we protect the kidneys after hypertensive pregnancy? Canadian Medical Association Journal. 2013; 185:199-200. Stewart C, Brennan FP. Legal Issues Concerning Withholding and Withdrawal of Dialysis. Nephrology 2013; 18: 444-449. Tranquilli AL, Brown MA, Zeeman GG, Dekker G, Sibai BM. The definition of severe and early-onset pre-eclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. 2013; 3: 44–47. Tranter S., Anastasiou A., Bazzi H., Burgess H. & Josland E. The renal memorial service: an important component of renal supportive care. Renal Society of Australasia Journal, 2013:9, 80-84. Urban K, Brennan FP. Patients who withdraw from dialysis in a Sydney centre with palliative care support: who, why, and how they die. Progress in Palliative Care. Available on-line February 1 2013. Other Published Material 2012 Eastabrook G, Brown MA, Sargent I. The Origins and EndOrgan Consequences of Pre-eclampsia In: Von Dadelzen P, Magee L (eds): Best Practice & Research Clinical Obstetrics & Gynaecology: Hypertension in Pregnancy (Issue 25.4). 2011: 435 – 447. Myint TM, Brown M, Fischer E. Pregnancy and dialysis. In: Harris D, Elder G, Kairaitis L, Rangan G. (editors) Clinical Dialysis. 2nd edition. McGraw Hill. Sydney. Australia. 2012: 90-96. 2013 Burns, T. Book review: “Nutritional Management of Renal Disease”. Renal Society of Australasia Journal, 2013: 9, 143. Chan M and Chadban S. Chapter 34: Nutritional management of renal transplantation. Kopple J, Massry S and Kalantar-Zadeh K. Textbook of Nutritional Management of Renal Disease. Third Edition. Elsevier Publishing, 2013. Chan, M and Trevino-Becerra, A. Nutrition, exercise and hemodialysis. Trevino-Becerra, A. (editor) Hemodialysis Esquematica. Publisher, Prado (Mexico) and translated into Spanish, 2013 Field, D. 2013. Book review: Understanding chronic kidney disease a guide for non-specialists. Renal Society of Australasia Journal, 9, 45. Josland, E. Book review “Kidney disease: From advanced disease to bereavement” Second edition. The Renal Society of Australasia Journal, 2013: 9, 142. Nutrition and Metabolism in Renal Disease (ICNMRD) Honolulu, Hawaii. June. Foo JY, Mangos G, Brown MA. Characteristics of hypertensive disorders in twin versus singleton pregnancies. Oral presentation at the XVIII ISSHP World Congress July 9th – 12th, Geneva. Switzerland. Josland E, Collett G, Brennan F, Brown MA. HOPE: Helping Older People with End stage kidney disease. Poster presentation at the BMJ International Forum on Quality and Safety in Healthcare 2012 Le Palais des Congrès, Paris, France; April. Mangos GJ, Ram J, Brown M. The effect of cuff size on automated blood pressure measurement. Poster presentation at the International Society of Hypertension Scientific Meeting, Sydney, September. Ong SLH, Williamson PM, Pirabhahar S, Beddoe J, Trajkovska B, Kelly JJ. Adequacy of blood pressure control in chronic kidney disease. Oral presentation at the International Society of Hypertension Scientific Meeting, Sydney, September. Ong SLH, Pirabhahar S, Trajkovska B, Cohen S, Williamson PM, Youssef G, Kelly JJ. Blood pressure, fluid volume, vascular and ventricular function in chronic kidney disease. Poster presentation at the International Society of Hypertension Scientific Meeting, Sydney, September. Williamson PM, Campbell J, Whitworth JA, Kelly JJ. The Effect of sustained release isosorbide mononitrate (Imdur) on cortisol-induced hypertension in healthy human subjects. Poster presentation at the International Society of Hypertension Scientific Meeting, Sydney, September. 2012 National Presentations at Scientific Meetings and Conferences Burns T. “Waiting for a kidney transplant in Australia – latest trends”. Oral presentation at the Transplant Nurses Association National Conference. Melbourne, November. 2012 International Collett G. Renal Supportive Care: Holistic care for advanced CKD patients and their families. NSW Palliative Care Conference, Dubbo, October. Brown M, Roberts L, Davis G, Mangos G. The UM-101 Mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? Poster presentation at the XVIII ISSHP World Congress. July 9th – 12th, Geneva. Switzerland. Chan M et.al. Nutritional characteristics and dietary intake of patients attending the pre-dialysis assessment clinic. Proceedings of the 16th International Congress of Nutrition and Metabolism in Renal Disease (ICNMRD) Honolulu, Hawaii, June. Chan M et.al. Self-reported appetite and intake adequacy In patients with non-dialysis chronic kidney disease. Proceedings of the 16th International Congress of Cuesta C, Robinson F, Blow, T & Mangos GJ Caring for a peritoneal dialysis patient with Epidermyolosis Bullosa. Oral presentation at the RSA conference, Melbourne. Josland E, Collett G, Foote C, Tranter S, Brennan F & Brown MA. Renal supportive care: holistic care for end stage kidney disease patients and their families. Paper presented at the 40th Renal Society of Australasia Annual Conference, Melbourne. Josland E. Hepatitis Protocol: Opening a can of worms. Oral presentation at the RSA conference, Melbourne. June. 45 Pirabhahar S, Robins J and Katz I. Assessment of Nephrologists’ Referrals: Preventing Burnout. Poster Presentation at the 48th Australian and New Zealand Society of Nephrology, Auckland, New Zealand, August. Moustakas J, Bennett P, Tranter S & Nicholson J. Supportive care: what does the ‘patient” want? Paper presented at the 40th Renal Society of Australasia Annual Conference, Melbourne, June. 2013 International Brown MA. Collett G, Josland EA, Brennan F. Non-dialysis management in the elderly: survival, symptom control and quality of life. American Society of Nephrology Kidney Week. Atlanta. USA. November. 2013 - National Chan, M, Tranter, S, Josland, E, Collett, G & Kelly J. 2013. Association of nurtritional status and the future choice of dialysis option in patients attending the multidisciplinary predialysis assessment clinic Top 10 poster presentation at the Renal Society of Australasia Conference Hobart. June. Chan M, Kelly J, Batterham M and Tapsell L. Nutritional characteristics and dietary intake of patients at enrolment to the pre-dialysis assessment clinic. Dietitians Association of Australia 30th National Conference, Canberra, May. Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and adequacy of energy and protein intakes in patients with non-dialysis chronic kidney disease, Dietitians Association of Australia 30th National Conference, Canberra, May 2013. Chan M, Kelly J, Batterham M and Tapsell L. Nutritional status is associated with the future treatment choice - renal replacement therapy vs. conservative care in end stage kidney disease patients attending the multidisciplinary pre-dialysis assessment clinic. 49th Australian and New Zealand Society of Nephrology (ANZSN) Annual Scientific Meeting, September. Cuesta, A, Tranter, S & Blow T. Taking control: addressing peritoneal dialysis related infection outcomes. Renal society of australasia Conference Hobart. June.. Pettit F, Davis G, Henry A, Mangos G, Brown MA. Is early onset pre-eclampsia worse for mother or baby? Society of Obstetric Medicine Australia and New Zealand. Annual 46 Scientific Meeting. Fremantle, WA. October. Tranter, S, Chan,M, Josland, E, Kerr E, McTaggart, S, Collett, G & Tapsell L. Nutritional profileof patients at enrolment to the multidisciplinary predialysis clinc 20022012. Top 10 poster presentation at the Renal society of australasia Conference, Hobart. June. Community Engagement A/Prof Ivor Katz is involved in the The development of a web-based Chronic Kidney Disease Outreach Program: improving clinical outcomes of CKD patients in the St George and Sutherland area. > Respiratory Medicine/Sleep Disorders St George Hospital Head of Department Steven Lindstrom: MBBS (Hons) FRACP Conjoint lecturer UNSW Senior Medical Elizabeth Clark: MFRCP, MBBS (Hons) Andrew Ng: MBBS, FRCP Con Archis: MBBS (Hons) John Moses: MBBS, FRACP Veronica Yozghatlian: MBBS, FRACP Frank Yan: BSc (Med) MBBS, FRACP Alexandra Smith: MBBS Junior Medical Saidul Ansary: MBBS Ajantha Ragapuran: MBBS Chin Goh: MBBS Alpanamarissa Antony: MBBS, MRCP Charles Prabhakar: BSC (Hons) MBBS Michael Ssentamu: MBChB; MRCP (UK) Research Staff Linda O’Malley: RN, CM Carol Gano: MND, BSc Jay Flack: BSC (2012; 2013) Cynthia Higgins: BSC (Nursing) (2012; 2013) Research Projects in Progress Industry Supported A Phase 3, double-blind, multi-centre, randomized, placebo-controlled trial evaluating repeated courses of Aztreonam for Inhalation solution in subjects with non-CF bronchiectasis and Gram-negative endobronchial infection (Gilead AIR-BX1 Principal Investigator Steven Lindstrom. A Phase 3, multi-centre, randomized, parallel group controlled, double-blind study to investigate the safety of inhaled Mannitol over 12 months for the treatment of Bronchiectasis (DPM-B-305) Principal Investigator Steven Lindstrom. A multi-centre, randomized, double blind, placebocontrolled, parallel group, single season study to assess the efficacy and safety of HI-1640V, an enteric coated oral Vaccine tablet containing 45 mg H1-164 active substance (inactivated, whole cells of non-typeable Haemophillus influenza, isolate 164) for reducing the rate and severity of acute exacerbations in patients with moderate to severe chronic pulmonary disease. (H1-H005) Principal Investigator, Elizabeth Clark. A Phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety and tolerability of two fixed dose combinations of Aclidinium Bromide/ Formoterol Fumerate compared to Aclidium Bromide/ Formeterol and placebo for 24 weeks treatment in patients with moderate to severe stable chronic obstructive pulmonary disease. (LAC-MD-31) Principal Investigator, Steven Lindstrom. A randomized, double-blind 12 week treatment, parallel group study to evaluate efficacy and safety of QMF149 (150mcg/160 mcg o.d.) compared to salmeterol xinafoate/ fluticasone proprionate (50mcg/500 mcg b.i.d.) in patients with chronic obstructive disease (QMF149F2202) Principal Investigator Steven Lindstrom. A randomized, double-blind placebo controlled study to compare the efficacy of indacaterol with that of placebo in patients with COPD who have not previously received maintenance COPD medication, using blinded tiotropium as active control. (QAB2425, INITIATE) Principal Investigator Steven Lindstrom. A Phase 3, double-blind, multi-centre, randomized, placebo-controlled trial evaluating repeated courses of Aztreonam for Inhalation solution in subjects with non-CF bronchiectasis and Gram-negative endobronchial infection (Gilead AIR-BX2) Principal Investigator, Steven Lindstrom. Randomized, double-blind, placebo controlled, multicentre study comparing Ciprofloxacin DPI 32.5 mg BID intermittently administered for 28 days on/28 days off or 14 days on/14 days off versus placebo to evaluate the time to first pulmonary exacerbation and frequency of exacerbations in subjects with non-cystic fibrosis bronchiectasis (RESPIRE) Principal Investigator Steven Lindstrom (temporary PI during LSL taken by Dr Lindstrom was Veronica Yozghatlian. Investigator initiated Cardiopulmonary exercise testing and quality life assessments in patients with lung cancer undergoing radiotherapy for curative intent. Principal Investigators: Dr Alpanamarissa Antony, Dr Steven Lindstrom, Dr Yiauw 47 Chin, A/Prof Peter Graham. Management of Pulmonary Embolism in a Hospital in the Home Setting: St George Hospital Experience Principal Investigator: Dr Alpanamarissa Antony supervised by Dr Steven Lindstrom. Procalcitonin use in the management of Community Acquired Pneumonia – a randomised trial Principal Investigator: Dr Chin Goh, supervised by Dr Steven Lindstrom. “Prevalence of sleep disordered breathing in an orthodontic population” ‘The Sleepy Teeth Study’ Principal Investigators: Dr Andrew Ng, Dr Chin Goh. Presentations at Scientific Meetings and Conferences 2013 - National Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience,: Royal Australasian College of Physicians (RACP) Congress, Perth, May. Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience,: St George Hospital Symposium, Sydney. Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience NSW Thoracic Society of Australia and New Zealand TSANZ NSW Branch Meeting, Sydney, November (recipient of the Tracey Robinson Award for the best oral presentation). Community Engagement Guidelines for the management of community acquired pneumonia, 2013 Dr Steven Lindstrom Video link to rural areas in NSW (supported by Agency of Clinical Innovation). 48 > Department of Rheumatology St George Hospital Head of Department A/Prof Allan Sturgess MB BS (UQld), PhD (UMelb), FRACP, FRCPA Senior Staff Specialist, Conjoint A/Prof Medicine UNSW Senior Medical Prof Marissa Lassere MB BS (USyd), PhD (UNSW), Grad Dip Epi (Newcastle), FRACP, FAFPHM. Senior Staff Specialist, Conjoint Prof. Medicine UNSW Dr Bill Giannakopoulos BSci (Med), MB BS (UNSW), PhD (UNSW), FRACP Senior Lecturer in Medicine UNSW, Consultant Rheumatologist St George Hospital Dr Ian Portek MB BS (USyd), FRACP VMO Rheumatology, St George Hospital Dr Lou McGuigan MB BS (UNSW), MD (UNSW), FRACP VMO Rheumatology, St George Hospital Junior Medical Dr Jeff Tsai, Advanced Trainee Rheumatology, 2012 Dr Aishwarya Sukhedo, Advanced Trainee Rheumatology, 2013 Senior Research Dr Kent Johnson BA (Harvard), BA (Oxford), MD (Johns Hopkins) Research Staff Sue Baker BAppSc (Biomed) (UTS) Tanya Thompson BSc (UNSW) Research Allied Health Guni Hinchey Grad Dip Sports (Germ.), Grad Dip Physio Cathy Brand (B Sci Anatomy), Postgrad Dip Physio Wendy Uptin BPhysio Research Grants NHMRC Project Grant 455467 Lassere MN, Sara T, Johnson K, Iedema R, Rubin G. Electronic portable health file (PHF) to promote quality of care and workflow through continuity of care. 2007-2012 $665,500 CIA evidence for surrogate therapeutics2008-2012 $510,00 CIA . UNSW GOLDSTAR Principal investigators. Marissa Lassere, Kent Johnson, Kerrie Mengersen, Mike Bradburn Clinical and statistical heterogeneity in meta-analysis, $40,000; 2012. UNSW GOLDSTAR, Principal investigators. Marissa Lassere, Kent Johnson, Jessie Berlin. Intelligent MetaAnalysis Models: Dealing With Heterogeneity, $40,000; 2013. Research Projects in Progress Long term outcome in patients with rheumatoid arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Baker S. Health-related quality of life in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Buchbinder R, Reid C, Lassere M, March L. Prevalence and predictors of all-cause hospitalization in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Williams B, Lassere M, March L, Buchbinder R, Reid C. Incidence and predictors of tuberculosis and other serious infections in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Carroll G, Buchbinder R, Lassere M, March L, Reid C. Incidence and predictors of malignancy in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Buchbinder R, Reid C, Lassere M, March L. Why patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis switch biologic agents. Williams M, Buchbinder R, Reid C, Lassere M, March L, Staples M. The reliability and validity of Power Doppler ultrasound in patients with rheumatoid arthritis. Joshua F, Lassere M. Development and evaluation of the Tolerability and Safety Questionnaire (TASQ): a patient-self report instrument of treatment related tolerability and safety for use in clinical trials. Lassere M, Johnson K. NHMRC Project Grant 510272 Lassere MN, Johnson KR, Dunsmuir W, Galbraith S, Ward R, Hughes M. Levels of 49 50 Evaluation of a prognostic measure of rheumatoid arthritis damage progression using MRI, arthroscopy and synovial membrane analysis. Kirkham B, Lassere M, Bird P, Edmonds, Portek I. An evaluation of the business, architectural, and workflow requirements of the patient held PHF and the healthcare provider electronic medical record to understand the shared information resources required to support a collaborative care model. Lassere M, Iedema R, Sara T. A randomised controlled trial to demonstrate the effectiveness, acceptability, and sustainability of a patientheld portable health file on improving patient outcomes. Lassere M, Johnson K, Iedema R, Sara T, Rubin G, Baker S. Investigate current statistical methods to advance biomarker and surrogate endpoint evaluation using simulated and real data sets that reflect limitations of data and statistical assumptions. Lassere M, Dunsmuir W, Galbraith S, Johnson K. The surrogate threshold effect (STE) of C-reactive protein onradiographic progression and functional disability in rheumatoid arthritis. Johnson K, Lassere M. Journal. 2013, 43 66-72 Poh M.Q.W., Lassere M., Bird P., Edmonds J. Reliability and longitudinal validity of computer-assisted methods for measuring joint damage progression in subjects with rheumatoid arthritis. Journal of Rheumatology. 2013, 40: 23-29 Johnson K. Letter to the Editor regarding Marciniak: Clinical Trial System is Broken, BMJ 347, 16 December 2013. Lassere M.N., Johnson K.R., Schiff M., Rees D. Is blood pressure reduction a valid surrogate endpoint for stroke prevention? an analysis incorporating a systematic review of randomised controlled trials, a by-trial weighted errorsin-variables regression, the surrogate threshold effect (STE) and the biomarker-surrogacy (BioSurrogate) evaluation schema (BSES). BMC Medical Research Methodology. 2012, Mar 12;12:27. doi: 10.1186/1471-2288-12-27 Presentations at Scientific Meetings and Conferences 2012 - International The surrogate threshold effect (STE) of HBA1c in patients with diabetes on cardiovascular events. Johnson K, Lassere M. Marissa Lassere, Biomarkers and Surrogate Endpoints: Food and Drug Administration, Washington DC, USA, June . The surrogate threshold effect (STE) of progressionfree survival for overall survival in metastatic renal cell carcinoma. Lassere M, Johnson K, Liauw W. Marissa Lassere, Biomarkers Therapeutics: Health Technology Group, Exeter University, Exeter, England, June. An evaluation of meta-analysis in the presence of heterogeneity performance (bias, accuracy and coverage) with varying trial parameters (size, number, treatment effect, and variability) using simulations. Johnson K, Lassere M, Mengersen K, Berlin J. Marissa Lassere, Biomarkers Review of Statistical Issues: National Cancer Institute: Bethesda Maryland USA November. A randomised controlled trial of a treat to target strategy versus usual care in patients with rheumatoid arthritis. LassereMN, Johnson KR, Sturgess A, Portek I, Edmonds J, Bird P, Carlton K. Cytokines, chemokines and vascular mediators of disease activity and damage in rheumatoid arthritis. Lassere MN, Sturgess A, Baker S. Meta-analysis of image-guided versus blind corticosteroid injection s in patients with arthritis. Johnson K, Lassere M, Tsai T, Buchbinder R. Original Peer-Reviewed Publications Lassere M.N, Rappo J., Portek I.J., Sturgess A., Edmonds J.P. How many life years are lost in patients with rheumatoid arthritis? Secular cause-specific and all-cause mortality in rheumatoid arthritis, and their predictors in a long-term Australian cohort study. Internal Medicine 2012 - National Marissa Lassere Australian Rheumatology Database: What we can learn from Biologics Registries. NSW Australian Rheumatology Meeting, 21 March, Sydney. Marissa Lassere, Electronic Health Records: 14thAustralian Annual Health Congress Sydney. March. 2013- International Marissa Lassere, Biomarkers Update on Statistical Issues: National Cancer Institute: Bethesda, Maryland USA November. 2013 - National Marissa Lassere, Systematic review of surrogate endpoints: University of NSW, Sydney, March. Marissa Lassere, What’s new (or old) in the medical management of osteoarthritis. St George Hospital Sydney September. 51 CANCER SERVICES Haematology > 53 Medical Oncology > 61 Palliative Care > 69 Radiation Oncology > 79 > Department of Haematology Head of Department Research Grants Professor Beng Chong, MBBS, PhD, FRCP, FRACP, FRCPA Professor, Department of Medicine (Conjoint) UNSW Director Clinical Haematology NHMRC Drug-induced immune thrombocytopenia BH Chong, M Davenport, $491,706 Jan 2011-Dec 2013. Senior Medical Professor Szu-Hee Lee, MBBChir, PhD, FRCPE, FRCPath, FRACP, FRCPA, Senior Staff Specialist, Conjoint Professor UNSW Staff Specialists Dr Sundra Ramanathan, MBBS, FRACP, FRCPA Dr Fernando Roncolato, B Med FRACP FRCPA Dr Xavier Badoux, MBBS, FRACP, FRCPA Dr Shir-jing Ho, MBBS, FRACP, FRCPA Dr Amanda Hugman, MBBS, FRACP, FRCPA Research Staff Dr Christine Hicks. BSc, MSc, PhD. Conjoint lecturer UNSW Scientific Staff Sudha Pillai, Haematology Laboratory Manager Susan Smith Deputy Haematology Laboratory Manager Senior Scientists NHMRC Heparin-induced thrombocytopenia and thrombosis: Better understanding of pathogenesis and improving diagnosis and treatment. BH Chong, C Parish $631,010 Jan 2012-Dec 2014. NSW Cancer Institute of NSW X. Badoux, ALLG Project Manager $287,000 2013-2015. Ho S, Cook C, Straube B, Fernandez R, et al. (2013-14). The Action Study: Strategies to reduce the VRE infection (Transmission and Bacteraemia) rates in high risk patients admitted to 4E/4N wards. SESLHD infection prevention and control enhancement program $100,000. Various Sponsor Companies as listed below in research projects in progress - Principal investigators:. Professor Beng Chong, Dr Sundra Ramanathan, Dr Fernando Roncolato, Dr Xavier Badoux, Dr Shir-jing Ho, Dr Amanda Hugman, $ 530,000 2012 , $ 565,000 2013. Unrestricted grant from GSK International I. ITP Registry: A Multi-centre, prospective disease registry for adults diagnosed with primary immune thrombocytopenia purpura (ITP) Asia-Pacific, Middle Eastern and S American countries 2011-2021, BH Chong ~$500,000 for 2012 2013. Rosalie Gemmell, Coagulation Laboratory Peter Loizou, Blood Bank Nella Mangos, Morphology: Christine Wassell. Bone Marrow Transplant Laboratory Clinical Trials Unit Roslyn Ristuccia BSc DipCompSc MMedSc(Epi), Manager Sarah Davidson RN Lorraine King RN Michael Szwajcer RN (CNS) Chris Sargent RN (CNS) Margaret Loizou BSc Elena Mendoza-Simon BSc Victoria Stevens BSc (Pharmacy) – Clinical Trials Pharmacist 53 Research Projects in Progress Short Title Trial - Title Principal Investigator ARES Anticoagulant Reversal and Events Study (ARES Collaborative) ASPIRE Aspirin to prevent recurrent venous thromboembolism. A multicentre, randomised, double-blind, placebo-controlled clinical trial Beng Hock Chong examining the efficacy and safety of low-dose aspirin after initial oral anticoagulation to prevent recurrent venous thromboembolism. CTBR-005 'HITS' Heparin-induced thrombocytopenia (HIT): Characterization of the pathogenic and non-pathogenic antibodies, and studies to improve laboratory diagnosis and treatment. Beng Hock Chong AMPLIFY EXTENSION A Safety And Efficacy Trial Evaluating the use of Apixaban for the Extended Treatment of Deep Vein Thrombosis and Pulmonary Embolism Beng Hock Chong AMPLIFY TREATMENT A Safety and Efficacy Trial Evaluating the Use of Apixaban in the Treatment of Symptomatic Deep Vein Thrombosis and Pulmonary Embolism Beng Hock Chong COMFORT 1 A Randomized, Double-blind, Placebo-controlled Study of the JAK Inhibitor INCB018424 Tablets Administered Orally to Subjects With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis Beng Hock Chong AMG 20080009 ITP BMT A Prospective, Phase IV, Open-Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects Receiving Romiplostim for the Treatment of Thrombocytopenia Associated with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) Beng Hock Chong The edoxaban HOKUSAI VTE Study A Phase 3, Randomized, Double-Blind, Double-Dummy, ParallelGroup, Multi-Center, Multi-National Study for the Evaluation of Efficacy and Safety of (LMW) Heparin/Edoxaban Versus (LMW) Heparin/Warfarin In Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism Beng Hock Chong The EINSTEIN VTE treatment study (St George Private Hospital) Oral direct factor Xa inhibitor rivaroxaban in patients with acute symptomatic deep-vein thrombosis or pulmonary embolism. The Einstein VTE study Beng Hock Chong TT4-ITP01 Triple Therapy for Primary Immune Thrombocytopenia (ITP) Beng Hock Chong M07-001 PNH Registry A global, observational, non-interventional study collecting effectiveness, safety and quality of life data on patients with Paroxysmal Nocturnal Haemoglobinuria (PNH) Disease. Beng Hock Chong Amgen MM Observational Study An Observational Study of Neutropenia in Subjects Being Treated for Relapsed or Relapsed/Refractory Multiple Myeloma Beng Hock Chong ITP Registry A Multi-centre, prospective disease registry for adults diagnosed with primary immune thrombocytopenia purpura (ITP) in international countries. Beng Hock Chong TWISTER Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis (TWISTER) Beng Hock Chong Biomarkers of IVIG efficacy during treatment of ITP Use of biomarkers as evidence based measurements of efficacy of IVIG treatment of Immune Thrombocytopenia Purpura ITP Beng Hock Chong 54 Amanda Hugman E5501 EISAI ITP A Phase 3, Multicenter, Randomised, Double-Blind, PlaceboControlled Parallel-group Trial with an open-label Extension Phase to evaluate the Efficacy and Safety of Oral E5501 plus Standard of care for the Treatment of Thrombocytopenia in Adults with Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenia purpura) Beng Hock Chong INCB 39110-230 An Open-Label, Multiple Simon 2-Stage Study of INCB039110 Administered Orally to Subjects With Primary Myelofibrosis (PMF), Post Polycythemia Vera-Myelofibrosis (PPV-MF) or Post Essential Thrombocythemia-Myelofibrosis (PET-MF) Beng Hock Chong TRC117146 GSK AML TRC 117146 is a randomised, single blinded, placebo-controlled, dose finding study to assess the PK interaction, safety and efficacy of the oral thrombopoietin receptor agonist, eltrombopag, administered to subjects with Acute Myelogenous Leukaemia (AML) receiving induction chemotherapy. Beng Hock Chong ASSIST GP13-301 A Randomized, Controlled, Double-Blind Phase III trial to Compare the Efficacy, Safety and Pharmacokinetics of GP2013 plus CVP vs. MabThera plus CVP, Followed by GP2013 or MabThera Maintenance Therapy in Patients with Previously Untreated, Advanced Stage Follicular Lymphoma Fernando Roncolato LEAF The Lymphoma Lifestyle, Environment And Family Study Fernando Roncolato ALLG Tissue Bank AMP Leukaemia and Lymphoma Tissue Bank A joint research initiative of ALLG and the Leukaemia Foundation Shir-jing Ho ALLG TIDEL II CML9 A Phase II study in adult patients with newly diagnosed chronicphase chronic myeloid leukaemia of initial intensified imatinib therapy and sequential dose-escalation followed by treatment with nilotinib in suboptimal responders to determine the rate and duration of major molecular response Shir-jing Ho ALLG MDS3 A Phase I/II trial to determine safety & efficacy of combination therapy with 5-azacitidine (Vidaza) and Thalidomide in patients with Myelodysplastic Syndromes (MDS) Shir-jing Ho ALLG NHL21 Early Treatment Intensification With R-ICE Chemotherapy and Autologous Stem Cell Transplantation for Patients with Poor Prognosis Diffuse Large B-Cell Lymphoma as Identified by Interim PET/CT Scan Performed After Four Cycles of R-CHOP-14 Chemotherapy Shir-jing Ho ALLG CLL5 OFOCIR An Australasian, phase II, multicentre, randomised, dose intensification study investigating oral fludarabine, oral cyclophosphamide and i.v. rituximab (poFCivR) tolerance in previously untreated elderly (= 65 years old) patients with chronic lymphocytic leukaemia Shir-jing Ho MDS4 A randomised Phase II study comparing the efficacy of 5azacitidine alone versus combination therapy with lenalidomide and 5azacitidine in patients with higher risk myelodysplastic syndromes (MDS) and low marrow blast count acute myeloid leukaemia (AML) Shir-jing Ho ALLG CML10 RESIST Response Post Tyrosine Kinase Inhibitor: Assessment of Sensitivity and Therapeutic Response to Next-Line Therapy in CML: The Australasian RESIST study Shir-jing Ho 55 Peritonectomy-PCC A Randomised Controlled Trial to Compare Administration of Prothrombin Complex Concentrate with Standard Haemostasis Management In Adult Patients Undergoing Peritoneal Cytoreductive Surgery Requiring Massive Transfusion. Shir-jing Ho AYA Pattern of Care Patterns and Experiences of Care in Adolescents and Young Adults with Cancer Shir-jing Ho ENDEAVOR MM A Randomized, Open-label, Phase 3 Study of Carfilzomib Plus Dexamethasone vs Bortezomib Plus Dexamethasone in Patients with Relapsed Multiple Myeloma Protocol Number 2011-003 Shir-jing Ho The ACTION study Strategies to reduce vre infection (transmission and bacteraemia) rates in high risk patients admitted to 4E/4N wards. Shir-jing Ho BP22333 Stage 1 A two-stage phase 1b study to investigate the pharmacokinetics in patients with follicular lymphoma (FL) as part of maintenance treatment Sundra Ramanathan BP22333 Stage 2 A two-stage phase 1b study to investigate the pharmacokinetics in patients with follicular lymphoma (FL) as part of maintenance treatment Sundra Ramanathan CLL 11 BO21004 An open-label, multi-center, three arm randomized, phase III study to compare the efficacy and safety of RO5072759+chlorambucil (GClb), rituximab + Chlorambucil (RClb) or chlorambucil (Clb) alone in previously untreated CLL patients with comorbidities. Sundra Ramanathan ALLG MM11 A phase 3, Multicentre, Randomized, Controlled study to determine the efficacy and safety of Cyclophosphamide, Lenalidomide and Dexamethasone (CRD) versus Melphalan (200mg/m2) followed by stem cell transplant in newly diagnosed multiple Myeloma subjects. Sundra Ramanathan GAUDI BO21000 An open-label, multi-centre,randomised, phase Ib study to investigate the safety and efficacy of RO5072759 given in combination with CHOP, FC or Bendamustine chemotherapy in patients with CD20+ B-cell follicular non-Hodgkin's lymphoma. Sundra Ramanathan REMARC NHL25 Double blind randomized phase iii study of lenalidomide (revlimid®)maintenance vs. Placebo in responding elderly patients with diffuse large b cell lymphoma and treated with r-chop in first line Sundra Ramanathan B1771007 Mantle Cell Lymphoma A Randomized Phase 4 study Comparing Intravenous Temsirolimus (TEMSR) Regimens in Subjects with Relapsed, Refractory Mantle Cell Lymphoma Sundra Ramanathan ENESTxtnd: CAMN107E2401 Extending molecular responses with Nilotinib in newly diagnosed chronic myeloid leukemia (CML) patients in chronic phase (ENESTxtnd) Sundra Ramanathan Psychosocial Outcomes An RCT Improving Psychological Outcomes for Haematological Cancer patients: An RCT Sundra Ramanathan Aplastic Anaemia Registry Aplastic Anaemia Registry (AA) Sundra Ramanathan ENDORSE EvaluatiNg outcomes of newly-DiagnOsed AML patients at St GeoRge Hospital, SydnEy, Australia. Sundra Ramanathan ALLG AML M16 Sorafenib in combination with intensive chemotherapy for previously untreated adult FLT3-ITD positive AML: a phase 2 randomised double-blind placebo controlled multi-centre study Sundra Ramanathan ALLG AML M18 Registry Australasian Leukaemia and Lymphoma Group Common Acute Myeloid Leukaemia Registry Sundra Ramanathan 56 High Dose Melphalan High dose melphalan: A pilot study to evaluate pharmacokineticbased dose determination in patients with multiple myeloma. Sundra Ramanathan ALLG MM14 A prospective randomised Phase II study of single agent pomalidomide maintenance versus combination pomalidomide and low dose dexamethasone maintenance following induction with the combination of pomalidomide and low dose dexamethasone in patients with relapsed and refractory myeloma previously treated with lenalidomide Sundra Ramanathan ALLG MM15 A randomized phase III study to compare Bortezomib, Melphalan, Prednisone (VMP) with High Dose Melphalan followed by Bortezomib, Lenalidomide, Dexamethasone (VRD) consolidation and Lenalidomide maintenance in patients with newly diagnosed multiple myeloma Sundra Ramanathan SAWYER BO25341 An Adaptive, comparative, randomised, parallel-group, multicenter, Phase 1b study of subcutaneous (SC) rituximab versus intravenous (IV) rituximab both in combination with chemotherapy (flurarabine and cyclophoshamide), in patients with previously untreated CLL Xavier Badoux ARD12042 A Randomized Phase II, Open-Label study of the Efficacy and Safety of Orally Administered SAR302503 in patients with polycythemia vera (PV) or essential thrombocythemia (ET) who are resistant or intolerant to hydroxyurea Xavier Badoux SAWYER BO25341 (Part 2) An Adaptive, comparative, randomised, parallel-group, multicenter, Phase 1b study of subcutaneous (SC) rituximab versus intravenous (IV) rituximab both in combination with chemotherapy (flurarabine and cyclophoshamide), in patients with previously untreated CLL Xavier Badoux Continuum A Phase 3, Multicenter, Randomized, Doubleblind, PlaceboControlled, Parallel-Group Study Of The Efficacy And Safety Of Lenalidomide (Revlimid®) As Maintenance Therapy For Patients With B-Cell Chronic Lymphocytic Leukemia Following Second Line Therapy Xavier Badoux Gilead CLL GSUS-312-0119 A Phase 3, Randomized, Controlled Study Evaluating the Efficacy and Safety of GS-1101 (CAL-101) in Combination with Ofatumumab for Previously Treated Chronic Lymphocytic Leukemia Xavier Badoux RESONATE PCYC-1115CA A Randomized, Multicenter, Open-label, Phase 3 Study of the Brutons Tyrosine Kinase Inhibitor PCI-32765 versus Chlorambucil in Patients 65 Years or Older with Treatment naive Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Xavier Badoux RESONATE 1116 Ext > 65yo An Open-label Extension Study in Patients 65 Years or Older with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Participated in Study PCYC-1115-CA (PCI32765 versus Chlorambucil) Xavier Badoux 57 Original Peer-Reviewed Publications 2012 Badoux X, Keating M, Wen, S, Wierda W, O’Brien S, Faderl S, Sargent R, Burger J, Ferrajoli A (2013; Epub 2012 Dec 26). Phase II Study of Lenalidomide and Rituximab As Salvage Therapy for Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia. Journal of Clinical Oncology, 31(5):584-91. Hicks, C, Trickett, A, Kwan, YL, Ramanathan, S. The use of adjusted ideal body weight for overweight patients undergoing HPC mobilisation for autologous transplantation. Annals of Hematology. 2012, Volume 91, Issue 11, pp 1795-1801. Chong BH. Drug-induced thrombocytopenia: MIBS trumps LIBS. Blood. 2012; 119 (26): 6177-8. PMID: 22745292. Zini G, d’Onofrio G, Briggs C, Erber W, Lee SH, NcFadden S, Yutaka N, Jou JM, Vives-Corrons JL, Lesesve JF. ICSH recommendations for identification and quantification of schistocytes. Int J Lab Hematol. 2012. 34(2): 107-116. 2013 Lee SH, van der Weyden C, Mayson E, Desai S. Excessive EDTA induces morphologic changes in bone marrow smears that mimic specific features of dysplasia. Int J Lab Hematol. 2013 Apr;35(2):163-9. Choi P, Gordon J, Harvey M, Chong B. Report on the Presentation and Outcome of ITP in Single Australian Centre. Intern Med J. 2012; 42(7):841-5. PMID:22805691. Porter JB, Elalfy MS, Taher AT, Aydinok Y, Chan LL, Lee SH, Sutcharitchan P, Habr D, Martin N, El-Beshlawy A. Efficacy and safety of deferasirox at low and high iron burdens: results from the EPIC magnetic resonance imaging substudy. Ann Hematol. 2013 Jan;92(2):211-9. Khachigian LM, Cai H, Moloney FJ, Parish CR, Chong BH, Stocker R, Barnetson RS, Halliday GM. Destroying c-Jun Messenger: New Insights into Biological Mechanisms of DNAzyme Function. Oncotarget. 2012; 3(6):594-5. PMID: 22805148. Braidy N, Gai WP, Xu YH, Sachdev P, Guillemin GJ, Jiang XM, Ballard JW, Horan MP, Fang ZM, Chong BH, Chan DK. Uptake and mitochondrial dysfunction of alphasynuclein in human astrocytes, cortical neurons and fibroblasts. Transl Neurodegener. 2013; 2(1): 20. Sanchez-Guerrero E, Chen E, Kockx M, An SW, Chong BH, Khachigian LM. IL-1beta Signals through the EGF Receptor and Activates Egr-1 through MMP-ADAM. PLoS One. 2012; 7(7):e39811. Epub 2012 Jul 6. PMID: 22792188. Perdomo J, Yan F, Chong BH. A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis and platelet production. Platelets.2013;24(2):98-106. Caii H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GI Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis . DJ, Moloney FJ, Barnetson RS, Halliday GM, Khachigian LM. DNAzyme Targeting c-jun Suppresses Skin Cancer Growth. Sci Transl Med. 2012; 4(139):139-82. PMID: 22723462. Coupland LA, Beng H. Chong, Christopher R. Parish. Platelets and P-selectin control tumor metastasis in an organ-specific manner and independently of NK cells. Cancer Research. Published Online July 26, 2012; doi: 10.1158/0008-5472.CAN-11-4010 Gao RL, Chong BH. Research and development of the effective components of panaxdiol saponin as new Chinese patent medicine for treating hemocytopenia. Chin J Integr Med. 2012; 18(12): 897-902. Perdomo J, Jiang XM, Carter DR, Khachigian LM, Chong BH. SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS One. 2012;7(11):e50637. Perdomo J, Yan F, Chong BH. A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis and platelet production. Platelets. 2013; 24(2):98-106. PMID: 22742725. 58 Chong BH, Chong JJ. HIT: nucleic acid masquerading as heparin. Blood. 2013; 122(2): 156-158. Chong BH, Choi PY, Khachigian L, Perdomo J. Druginduced immune thrombocytopenia. Hematol Oncol Clin North Am. 2013; 27(3):521-40. Coupland LA, Chong BH, Parish CR. Beware of NK Cells in Pre-clinical metastasis models. Clin Exp Metastasis. 2013; 30(7):945-7 Sanchez-Guerrero E, Jo SR, Chong BH, Khachigian LM. EFGR and the complexity of receptor crosstalk in the cardiovascular system Curr Mol Med. 2013; 13(1): 3-12. Review. Tsimberidou AM, Wierda WG, Wen S, Badoux XC, et al. Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome. Clin Lymphoma Myeloma Leuk. 2013;13(5):568-74. Strati P, Keating MJ, Wierda WG, Badoux XC et al. Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia. Blood. 2013;122(5):734-7. Badoux XC, Keating MJ, Wen S, et al. Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol. 2013;31(5):584-91. National Blood Centre, Haematology seminar. “Making platelets in a flask” Kuala Lumpur, Malaysia Other Published Material The International Society on Thrombosis and Haemostasis, Liverpool, United Kingdom, June 27-30, 2012. 58th Annual SSC Meeting, Platelet Immunology Subcommittee: “Drug-induced immune thrombobocytopena: Animal Model”; “ Effects of drug-induced antibody on megakaryocytes.” Hsu D, Lee SH. Digital Imaging in Hematology. In Laboratory Hematology Practice. Eds Marchant KM, Davis B. Wiley-Blackwell. 2012. pp707-718 Greinacher A, Warkentin TE, Chong, BH. Heparin-induced Thrombocytopenia, In Platlelets (3rd Edition) Ed Michelson AD, Academic Press New York. 2012. Chong BH, van der Weyden, Carrie. Deep vein thrombosis and pulmonary embolism, in: Disease Index (Fifth Edition) Ed: Worth O, MIMS Australia, 2012 . Chong BH, Magnani HN. Danaparoid in the treatment of heparin-induced throbocytopenia, in: Heparin-induced Thrombocytopenia, Eds: Warkentin T, Greinacher A. 5th Edition. Marcel Dekker, New York 2012. Presentations at Scientific Meetings and Conferences 2012 - International Professor Beng Hock Chong ITP lecture series April 5-9, 2012.Apollo Hospital Group, Chennai, India. 2012 April 5. “ITP Update.” Chhatrapati Shahuji Maharaj Medical University (formerly King George Medical) Locknow, India, 21012 April 6. “Management of ITP: New agents. “ National Haematology Update IX conference, 2012, organized by the All India Institute of Medical Sciences, New Delhi, April 7. “Management of ITP: International Guidelines – Consensus and Differences. “ Tata Medical Centre and University, Kolkata, India. 21012, April 9. “HIT and HITT. “Diagnosis and Management of ITP.” Royal College of Pathologists of Australasia South-east Asia Lecture series June 5-12, 2012. Chapter of Haematologists, College of Physicians, “How I treat ITP patients including the pregnant patient.” Singapore Academy of Medicine, College of Pathologists, Annual Meeting 2012 (Keynote Address) K Pratap Memorial Lecture.” New Dawn In Laboratory Medicine.” Malaysia University Putra Malaysia Haematology seminar. “Updates on laboratory tests for immune platelet disorders”, “Platelet function abnormalities in Myeloproliferative Neoplasm and their laboratory testing.” Malaysia Invited speaker by Hong Kong Association of Blood Transfusion and Haematology and by Queen Mary Hospital, HK: 26 -30 november 2012. Titles: (1) ITP: pathogenesis & treatment; (2) Heparin-induced thrombocytopenia; (3). Molecular regulation of thrombopoiesis; (4) Anti-platelet therapy: basics & recent advances. Prof Szu-Hee Lee Invited Speaker, “Optimizing the Quality of Bone Marrow Specimens and Reports”, International Society for Laboratory Hematology 2012, Nice, France, May 2012. Int.J.Lab.Hematol. 2012, 34 (Suppl. 1): 32-33). 2012 - National Prof Beng Hock Chong Invited Speaker: ITP symposium Haematology Further Education Activity, ITP in Australia Perth Feb 17 and Melbourne Feb 20. Invited Speaker : Pathology Update, Royal College of Pathologists of Australasia, Sydney March 9-11,2012 “Drug-induced immune thrombocytopenia: Pathogenesis, diagnosis and treatment.” 2013 - International Prof Beng Hock Chong Taiwan Haematology Society Annual Meeting, Taipei, 13th -14th April, 2013: “Clinical decision making in ITP: When to treat and how to treat.” 10th Malaysian Society of Haematology Scientific Meeting 26 to 28th April 2013, Penang Malaysia. “Megakaryocytopoiesis and Haemostasis in Normal subject”; “The therapeutic use of thrombopoietic agents and clot promoting factors” Hicks C., Goodman N., Gemmell R., Roncolato F., Ramanathan S. Platelet harvest, cryopreservation and infusion; Re-expanding the resources of the BMT lab. Exp Hem 41(8) S1. Abstract. International Society for Experimental Haematology ISEH. Vienna 2013 59 2013 - National Gemmell R, Cavanaugh L, Hicks C, Roncolato F, Chong, B. Platelet Function Testing of cryopreserved platelets. Abstract. HAA Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and Haemostasis, Broadbeach, Queensland, 20-23 October. Chong, BH. Carl de Gruchy Memorial Lecture, Title: Platelet: Small Cell Big Impact, St Vincent Hospital, Melbourne. 16 September. Community Engagement Professor Beng Chong Member of the Board of St George Medical Research Foundation and Deputy Chair, Scientific Advisory Committee, St George Medical Research Foundation. Member, Medical and Dental Appointments Committee, St George Hospital, Sydney Member of Clinical Council, St George Hospital, Sydney Council member, Asia-Pacific Society of Thrombosis and Haemostasis Vice-President, Australian Bid Committee, International Society of Thrombosis and Haemostasis Prof Szu-Hee Lee Chair of the Science and Education Committee of the International Society of Haematology, Asia-Pacific Division (ISHAPD) since 1997 Vice-President of the International Council for Standardization in Hematology (ICSH) since 2009 Co-Chief Editor of the International Journal of Laboratory Hematology since 2010 Member, Editorial Board, Pathology Member, International Advisory Panel, Malaysian Journal of Pathology Vice-Chair, International Council for Standardization in Haematology. 60 > Department of Medical Oncology Head of Department Research Grants Dr Kiran Phadke MB CHB FRACPA FRACP NSW Cancer Institute Associate Professor Winston Liauw Cancer Clinical Trials Staff Grant $262,581 2012-2014. Senior Medical Dr Patricia Bastick MB BS BMedSc FRACP Grad Cert Epidemiology, Conjoint Associate Lecturer UNSW Dr Chee Lee MB BS MMEDSC (Clinical Epidemiology) FRACP MBiostats PhD Associate Professor Winston Liauw, MB BS MMedSC FRACP GAICD Grad Cert Politics and Policy Conjoint Associate Professor Matthew Links, MB BS FRACP PhD Dr Jodi Lynch, MB BS FRACP Dr Katrin Sjoquist, MB BS BSc Med FRACP MClinT Dr David Thomas, MB BS FRACP Research Staff Peter Fink BSc – Manager, Clinical Trials Unit Clinical Trials Coordinators Antoinette Fontela BSc Mary Margaret Gozar PhD Stephen Millard CNS Indira Mismit RN Shu Pan BSc Penelope Taylor CNS Lisa Wang MSc Victoria Stevens BPharm – Clinical Trials Pharmacist Cancer Australia L.Mileshkin, M.Quinn, P.Khaw, C.Creutzberg, M.Stockler, A. Brand, J. Martyn, K. Sjoquist Randomised Phase III Trial Comparing Concurrent Chemo- radiation and Adjuvant Chemotherapy with Pelvic Radiation Alone in High Risk and Advanced Stage Endometrial Carcinoma: PORTEC-3 $300,878 2012-2014. University of Sydney Cancer Research Fund Grant (CRFG). M.Friedlander, K Sjoquist Intraperitoneal Bevacizumab Therapy in Malignant Ascites, $50,000 2011-2012. Ovarian Cancer Research Foundation (OCRF) D Robertson, H Burger, M Friedlander, K Sjoquist, J Martyn. The role of Inhibin as a biomarker of response in Granulosa Cell Tumours $20,000 2012-2014. Cancer Australia Project Grant 626201 Principal investigators A/Prof P Graham, Prof G Delaney, Dr E Millar, Dr Anne Capp, Als Prof R Sutherland, Dr S Carroll, Dr J Harvey, Dr J Lynch, Dr R Tse. Trans Tasman Radiation Oncology Group 08.06: A Randomised comparison of anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. (STARS – Study of Anastrozole and Radiotherapy Sequencing). $660,000 2010-2012. 61 Research Projects in Progress Short Name Title Principal Investigator COMPARZ Study VEG108844, a Study of Pazopanib Versus Sunitinib in the Treatment of Subjects With Locally Advanced and/or Metastatic Renal Cell Carcinoma BETH A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients With HER2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab With Chemotherapy Plus Trastuzumab Plus Bevacizumab BCIRG 006 Randomized phase III trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC->T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC->TH) and with docetaxel, platinum salt and trastuzumab (TCH) in the adjuvant treatment of node positive and high risk node negative patients with operable breast cancer containing the HER2neu alteration. Matthew Links Carbo/Tax CARBO/TAX: Wkly Carboplatin + Taxol and Concomitant RT for locally advanced NSCLC: Predictors of Rx Tolerance. Matthew Links SOFT A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant therapies for premenopausal women with endocrine responsive breast cancer. Jodi Lynch BCIRG 005 Randomized phase III trial comparing docetaxel in combination with doxorubicin and cyclophosphamide (TAC) versus doxorubicin and cyclophosphamide followed by docetaxel (AC->T) as adjuvant treatment of operable breast cancer HER2neu negative patients with positive axillary lymph nodes Matthew Links AG0102 GIST Phase III randomised, multi-centre, international trial to determine the relation between dose and clinical activity of STI-571 in patients with unresectable or metastatic malignant gastrointestinal stromal tumors expressing the c-kit receptor tyrosine kinase (CD117). Matthew Links CO.20 A phase III randomised study of Brivanib (BMS-582664) in combination with Cetuximab (Erbitux½) versus Placebo in combination with Cetuximab (Erbitux½) in patient previously treated with combination chemotherapy for metastatic colorectal carcinoma Winston Liauw RAD001 A Phase 1 study of RAD001 (everolimus) in combination with fluvastin and zoledronic acid in patients with solid tumours Matthew Links TEACH A Randomized, Double-Blind, Multicenter, Placebo-Controlled Study of Adjuvant Lapatinib (GW572016) in Women With EarlyStage ErbB2 Overexpressing Breast Cancer Jodi Lynch VEG102616 Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of GW786034 in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC). Winston Liauw 62 Winston Liauw Jodi Lynch Inspire A Randomized, Multicenter, Open-Label Phase 3 Study of Pemetrexed-Cisplatin Chemotherapy Plus IMC-11F8 Versus Pemetrexed-Cisplatin Chemotherapy Alone in the First-Line Treatment of Patients With Nonsquamous Stage IIIb or IV NonSmall Cell Lung Cancer (NSCLC) Matthew Links Squire A Randomized, Multicenter, Open-Label, Phase 3 Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab (IMC11F8) Versus Gemcitabine-Cisplatin Chemotherapy Alone in the First- Line Treatment of Patients With Stage IV Squamous NonSmall Cell Lung Cancer (NSCLC) Matthew Links D-Care A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study of Denosumab as Adjuvant Treatment for Women with Early-Stage Breast Cancer at High Risk of Recurrence (D-CARE) Jodi Lynch CATS Prediction of cardiotoxicity by measurement of serum N-terminal pro-B-type natriuretic peptide in breast cancer patients receiving adjuvant trastuzumab Jodi Lynch BCIRG 006 Sub study Multicenter Phase III Randomized Trial Comparing Doxorubicin And Cyclophosphamide Followed By Docetaxel (AC®T) With Doxorubicin And Cyclophosphamide Followed By Docetaxel And Trastuzumab (Herceptin®) (AC®TH) And With Docetaxel, Carboplatin And Trastuzumab (TCH) In The Adjuvant Treatment Of Node Positive And High Risk Node Negative Patients With Operable Breast Cancer Containing The Her2 Alteration. Breast Cancer Recurrence Substudy Matthew Links CA184095 Randomized, Double-Blind, Phase 3 Trial to Compare the Efficacy of Ipilimumab vs Placebo in Asymptomatic or Minimally Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer Patricia Bastick Rainbow A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase 3 Study of Weekly Paclitaxel With or Without Ramucirumab (IMC-1121B) Drug Product in Patients With Metastatic Gastric Adenocarcinoma, Refractory to or Progressive After First-Line Therapy With Platinum and Fluoropyrimidine Winston Liauw BR.26 A Double Blind Placebo Controlled Randomized Trial Of PF-804 In Patients with Incurable Stage IIIb/IV Non-Small Cell Lung Cancer After Failure Of Standard Therapy For Advanced Or Metastatic Disease Matthew Links Predict IR The Utility Of Genomics And Functional Imaging To Predict Irinotecan Pharmacokinetics And Pharmacodynamics: The Predict IR Study Winston Liauw Marquee A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study Of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib In Previously Treated Subjects With Locally Advanced Or Metastatic, Non-Squamous, Non–Smallcell Lung Cancer (NSCLC) Matthew Links Bolero 3 A randomized Phase III, double-blind, placebo-controlled multicenter trial of daily everolimus in combination with trastuzumab and vinorelbine, in pretreated women with HER2/neu over-expressing locally advanced or metastatic breast cancer Patricia Bastick 63 Gamma A Phase 3, multicenter, randomized, double-blind, placebo controlled trial of AMG 479 or placebo in combination with Gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas Winston Liauw TADE A Multi-Centre Study of Tamoxifen Dose Escalation Study in Breast Cancer Patients with CYP2D6 Polymorphisms Jodi Lynch Th3resa A Phase III Randomized, Multicenter, Two-Arm, Open-Label Trial to Evaluate the Efficacy of Trastuzumab Emtansine Compared With Treatment of Physician's Choice in Patients With HER2 Positive Metastatic Breast Cancer Who Have Received at Least Two Prior Regimens of HER2 Directed Therapy Patricia Bastick Attache A Trial in the Timing of Surgery and Adjuvant Chemotherapy for Hepatic Metastases from Colorectal Cancer. A phase III, multi-centre, randomised trial comparing perioperative morbidity between those given chemotherapy prior to and post surgical resection versus those given chemotherapy post surgical resection. Winston Liauw Fergi A Phase II, Double-Blind, Placebo Controlled, Randomized Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Patients Resistant to Aromatase Inhibitor Therapy Jodi Lynch SafeHer A Phase III Prospective, Two-Cohort Non-Randomized, MultiCentre, Multinational, Open Label Study To Assess The Safety Of Assisted- And Self-Administered Subcutaneous Trastuzumab As Adjuvant Therapy In Patients With Operable Her2-Positive Early Breast Cancer Patricia Bastick IDEate Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab Plus Etoposide/Platinum Versus Etoposide/Platinum in Subjects With Newly Diagnosed ExtensiveStage Disease Small Cell Lung Cancer (ED-SCLC) Chee Lee Baton A Phase 2, Open Label, Multicenter, Randomized Trial Comparing Tivozanib in Combination With mFOLFOX6 to Bevacizumab in Combination With mFOLFOX6, In Stage IV Metastatic Colorectal Cancer (mCRC) Subjects Winston Liauw Lux Lung-7 A Randomised, Open-label Phase IIb Trial of Afatinib Versus Gefitinib as First-line Treatment of Patients With EGFR Mutation Positive Advanced Adenocarcinoma of the Lung TOPS Trial A controlled trial of an optimized multidisciplinary intervention for post-cancer fatigue Patricia Bastick Integrate A randomised phase II double-blind study to evaluate the effect of Regorafenib or placebo on progression-free survival and objective response rate in refractory advanced oesophago-gastric cancer (AOGC) Katrin Sjoquist Affinity A Randomized Phase 3 Study Comparing Cabazitaxel/Prednisone in Combination With Custirsen (OGX-011) to Cabazitaxel/ Prednisone for Second-Line Chemotherapy in Men With Metastatic Castrate Resistant Prostate Cancer. Patricia Bastick Mic-1 Phase II study investigating the ability of Macrophage Inhibitory Cytokine-1 (MIC-1) and associated plasma markers to predict response to chemotherapy in men with metastatic castrateresistant prostate cancer Patricia Bastick 64 Chee Lee Dareck A Phase II, Multicenter, Open-Label, Randomized Study Evaluating the Efficacy and Safety of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI in Second Line in Patients With KRAS Wildtype Metastatic Colorectal Cancer Winston Liauw M10-897 A Randomized, Double-Blind, Phase 2, Dose-Ranging Study to Evaluate the Safety and Efficacy of Veliparib and Whole Brain Radiation Therapy Versus Placebo and Whole Brain Radiation Therapy in Subjects With Brain Metastases From Non-Small Cell Lung Cancer. Matthew Links BEZ235 Randomized phase II study of BEZ235 or everolimus in advanced pancreatic neuroendocrine tumours. Winston Liauw Enspirit A Multinational, Randomized, Open-Label Phase III Study of Custirsen (TV-1011/OGX-011) In Combination With Docetaxel Versus Docetaxel As A Second-Line Treatment In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer Everexes A phase IIIb, multi-center, open-label, expanded access study of EVERolimus (RAD001) in combination with EXemestane in postmenopausal women with EStrogen receptor positive, human epidermal growth factor receptor 2 negative locally advanced or metastatic breast cancer EVEREXES Patricia Bastick TACTIC A randomised phase II study evaluating the potential molecular profile of biliary tract cancer and also examining the clinical benefit and safety of panitumumab, cisplatin and gemcitabine in the treatment of biliary tract cancer. Winston Liauw CHALLENGE A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial Winston Liauw AMG386 A Phase 1b/2 Trial of AMG 386 in Combination With Pemetrexed and Carboplatin as First Line Treatment of Metastatic NonSquamous Non-Small Cell Lung Cancer Matthew Links CO23 A Phase Iii Randomized Study of Bbi608 and Best Supportive Care versus Placebo and Best Supportive Care In Patients with Pretreated Advanced Colorectal Carcinoma Winston Liauw Aura Safety, Tolerability, Pharmacokinetics & Antitumour Activity of AZD9291 in Patients With Advanced Non Small Cell Lung Cancer Who Have Progressed on Prior Therapy With an Epidermal Growth Factor ReceptorTyrosine Kinase Inhibator Agent Chee Lee Chee Lee 65 Original Peer-Reviewed Publications 2012 Chua, T., Al-Alem, I., Zhao, J., Glenn, D., Liauw, W., & Morris, D. (2012). Radiofrequency Ablation of Concomitant and Recurrent Pulmonary Metastases after Surgery for Colorectal Liver Metastases. Annals of Surgical Oncology, 19(1), 75-81. Chua, T., Liauw, W., & Morris, D. (2012). Early recurrence of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and perioperative intraperitoneal chemotherapy is indicative of a poor survival outcome. International Journal of Colorectal Disease, 27(3), 381-389. Chua, T., Liauw, W., Zhao, J., & Morris, D. (2012). Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal peritoneal carcinomatosis. International Journal of Clinical Oncology, Jun;18(3):439-46. Chua, T. C., Chong, C. H., Liauw, W., & Morris, D. L. (2012). Approach to Rectal Cancer Surgery. International Journal of Surgical Oncology, 2012 2012. Published on line June 27 2012: Article ID 247107. Chua, T. C., Chong, C. H., Liauw, W., Zhao, J., & Morris, D. L. (2012). Inflammatory Markers in Blood and Serum Tumor Markers Predict Survival in Patients With Epithelial Appendiceal Neoplasms Undergoing Surgical Cytoreduction and Intraperitoneal Chemotherapy. Annals of Surgery, 256(2), 342-349. Chua, T. C., Liauw, W., Chu, F., & Morris, D. (2012). Viewing Metastatic Colorectal Cancer as a Curable Chronic Disease. American Journal of Clinical Oncology, 35(1), 77–80. Chua, T. C., Liauw, W., Chu, F., & Morris, D. L. (2012). Summary outcomes of two-stage resection for advanced colorectal liver metastases. Journal of Surgical Oncology, 2013 Feb;107(2):211-6. Chua, T. C., Moran, B. J., Sugarbaker, P. H., Levine, E. A., Glehen, O., Gilly, F. N., Baratti, D., Deraco, M., Elias, D., Sardi, A., Liauw, W., Yan, T. D., Barrios, P., Gómez Portilla, A., de Hingh, I. H. J. T., Ceelen, W. P., Pelz, J. O., Piso, P., González-Moreno, S., Van Der Speeten, K., & Morris, D. L. (2012). Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Journal of Clinical Oncology, 30(20), 2449-2456. Chua, T. C., Saxena, A., Liauw, W., Chu, F., & Morris, D. L. (2012). Hepatectomy and resection of concomitant extrahepatic disease for colorectal liver metastases – A systematic review. [doi: 10.1016/j.ejca.2011.10.034]. European Journal of Cancer (0). 66 Dimoska, A., Butow, P. N., Lynch, J., Hovey, E., Agar, M., Beale, P., & Tattersall, M. H. N. (2012). Implementing patient question-prompt lists into routine cancer care. [doi: 10.1016/j.pec.2011.04.020]. Patient Education and Counseling, 86(2), 252-258. C.K. Lee, C. Brown, R. Gralla, V. Hirsh, A. Inoue, V. Gebski, C.J. Yang. Impact Of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Treatment In Advanced Non-Small Cell Lung Cancer: A Meta-Analysis. Annals of Oncology 2012, 23 (suppl 9): ix400-ix446. Chee Khoon Lee, Ian Marschner, R John Simes, Merryn Voysey, Brian Egleston, Gary Hudes, Paul de Souza. Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus. Clinical Cancer Research 2012, 18(11), 3188–3196. C. K. Lee, R. J. Simes, C. Brown, V. Gebski, J Pfisterer, A-M. Swart, D. Berton-Rigaud, M. Plante, T. Skeie-Jensen, I. Vergote, C. Schauer, C. Pisano, G. Parma, K. Baumann, J. A. Ledermann, E. Pujade-Lauraine, J. Bentley, G. Kristensen, A. Belau, M. Nankivell, U. Canzler, S. J. Lord, C. Kurzeder, M. Friedlander. A prognostic nomogram to predict overall survival in patients with platinum-sensitive recurrent ovarian cancer. Annals of Oncology 2012. 2013 Apr;24(4):937-43. Links, M., Sargeant, C., Waters, A., Liauw, W., & Thomas, P. (2012). Implementing a Multi-professional Web-based Learning Environment for a Comprehensive Cancer Centre: Obstacles, Solutions and Reflections. Journal of Cancer Education, 27(1), 37-41. Verry H, Lord SJ, A Martin A, Gill G, Lee CK, Howard K, Wetzig N, Simes J. Effectiveness and cost-effectiveness of sentinel node biopsy compared with axillary node dissection in patients with early stage breast cancer: a decision model analysis. British Journal of Cancer 2012, 106, 1045–1052. Waller, A., Girgis, A., Johnson, C., Lecathelinais, C., Sibbritt, D., Forstner, D., Liauw, W., & Currow, D. C. (2012). Improving Outcomes for People With Progressive Cancer: Interrupted Time Series Trial of a Needs Assessment Intervention. Journal of Pain and Symptom Management, 43(3), 569-581. 2013 Lobb, E. A., J. Lacey, J. Kearsley, W. Liauw, L. White and A. Hosie (2013). Living with advanced cancer and an uncertain disease trajectory: an emerging patient population in palliative care? BMJ Supportive & Palliative Care. 2013 Jan 29. Sommeijer, D. W., K. M. Sjoquist and M. Friedlander (2013). Hormonal Treatment in Recurrent and Metastatic Gynaecological Cancers: A Review of the Current Literature. Current Oncology Reports: 2013 Dec;15(6):5418. Price TJ, Hardingham JE, Lee CK, Townsend AR, Wrin JW, Wilson K, et al. Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. Cancer Medicine 2013, doi: 10.1002/cam4.75. Lee CK, Brown C, Gralla RJ, Hirsh V, Thongprasert S, Tsai C-M, Tan EH, Ho JC-M, Chu DT, Zaatar A et al. Impact of EGFR Inhibitor in Non–Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis. Journal of the National Cancer Institute 2013, 105(9):595605. You B, Colomban O, Heywood M, Lee C, Davy M, Reed N, Pignata S, Varsellona N, Emons G, Rehman K, Steffensen KD, Reinthaller A, Pujade-Lauraine E, Oza A. The strong prognostic value of KELIM, a model-based parameter from CA 125 kinetics in ovarian cancer: Data from CALYPSO trial (a GINECO-GCIG study). Gynecologic Oncology 2013, doi:10.1016/j.ygyno.2013.05.013. Peter Fox, Malcolm Hudson, Chris Brown, Sarah Lord, Val Gebski, Paul De Souza, Chee Khoon Lee. Markers of systemic inflammation predict survival in patients with advanced renal cell cancer. British Journal of Cancer 2013, 109, 147–153. Chee Khoon Lee, Val J Gebski, Alan S Coates, AnneSophie Veillard, Vernon Harvey, Martin HN Tattersall, Michael J Byrne, Brian Brigham, John Forbes, R John Simes and on behalf of Australia and New Zealand Breast Cancer Trials Group (ANZBCTG). Trade-offs in quality of life and survival with chemotherapy for advanced breast cancer: mature results of a randomized trial comparing single-agent mitoxantrone with combination cyclophosphamide, methotrexate, 5-fluorouracil and prednisone. SpringerPlus 2013, 2:391. Felicia Roncolato, Pei Ding, Sally Lord, Val Gebski, Chee Khoon Lee. Risk of Treatment-related Mortality with Bevacizumab treatment in advanced cancers. European Journal of Cancer 2013; 49, Supplement 2. Pei Ni Ding, Richard Gralla, Akira Inoue, Sally Lord, Nick Pavlakis, Tetsuya Mitsudomi, Matthew Links, Val Gebski, James C. Yang, Chee Khoon Lee. Exon 19 deletions, smoking history and gender as additional predictive factors for treatment benefit with EGFR Tyrosine Kinase Inhibitors in patients harbouring activating EGFR mutations: A Meta-analysis of 1432 patients in six randomised trials. Journal of Thoracic Oncology 2013; 8, Supplement 2, S593. Pei Ni Ding, Sally Lord, Matthew Links, Victoria Bray, Val Gebski, James C. Yang, Chee Khoon Lee. Toxicity of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) in the Treatment of Advanced NonSmall Cell Lung Cancer (NSCLC): A Meta-analysis. Journal of Thoracic Oncology 2013; 8, Supplement 2, S593, Other Published Material Chow, Hui Ting, Tran, Kim, Millar, Ewan K. A., Lynch, Jodi, Murrell, Dedee F. (2012). Diverse Presentations of Carcinoma Erysipelatoides from a Teaching Hospital in Australia. Case Rep Dermatol Med. 2012; 2012: 134938. Links, M., & Galettis, P. (2012). One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine (20 April, 2012 ed.): InTech, April, 2012. Presentations at Scientific Meetings and Conferences 2012 International YJ Chua, C Karapetis, C Underhill, L M.Nott, D Goldstein, M Cronk, V Gebski, N Wong, K M Sjoquist, A Biankin, Australasian Gastrointestinal Trials Group (AGITG) PAN1: A randomized phase II study evaluating potential predictive biomarkers in the treatment of metastatic pancreatic cancer. Poster, American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, June 2012. J Fawcett, K M Sjoquist, R Padbury, C Christophi, N Tebbutt, C Pilgrim, VGebski, N Wong, CE Aiken, D Goldstein, Australasian Gastro-Intestinal Trials Group (AGITG) ATTACHE: A phase III, multicenter, randomized comparison of chemotherapy given prior to and postsurgical resection versus chemotherapy given post-surgical resection for hepatic metastases from colorectal cancer. Poster, ASCO Annual Meeting, Chicago, June 2012. Price TJ, Hardingham J, Lee C, Wrin J, Townsend A, Wilson K, Weickhardt A, Simes J, Murone C, Tebbutt N. Analysis of PTEN in patients with advanced colorectal cancer (CRC) receiving capecitabine alone or in combination with bevacizumab with or without mitomycin C in the phase III AGITG MAX trial. Journal of Clinical Oncology, ASCO Annual Meeting Proceedings, Chicago, June 2012; 30 (15 suppl): 3534. Sjoquist KM, Lee C, Lord S, Chatfield M, Friedlander M, Simes J, Marschner I. Progression-free survival (PFS) as a surrogate end point for overall survival (OS) in first-line treatment of advanced epithelial ovarian cancer (EOC). Journal of Clinical Oncology, ASCO Annual Meeting Proceedings 2012; 30 (15 suppl): 5081. K Sjoquist, C Lee, S Lord, M Chatfield, M Friedlander, RJ Simes, I Marschner. Progression Free Survival (PFS) is a valid surrogate end point for overall survival (OS) in first line treatment of advanced epithelial ovarian cancer (EOC). Poster, ASCO Annual Meeting, Chicago, June 2012. 67 2012 National K Sjoquist Interpreting Clinical Trial Data: Prognostic and Predictive Factors Invited speaker, Cancer Pharmacy Practitioners Advanced Course November 2012, Melbourne. K Sjoquist Targeted Therapies – assessing and grading common toxicities Invited speaker, Australasian Gastrointestinal Trials Groups (AGITG) Annual Scientific Meeting September 2012, Sydney. 2013 International Michael M. Vickers, Dongsheng Tu, Chee Lee, Paul Wheatley-Price, Wendy Parulekar, Michael Donald Brundage, Malcolm J. Moore, Heather-Jane Au, Christopher J. O’Callaghan, Derek J. Jonker, Jolie Ringash, David Goldstein. Significance of baseline quality of life scores in predicting clinical outcomes in an international phase III trial of advanced pancreatic cancer: NCIC CTG PA.3. Journal of Clinical Oncology, ASCO Annual Meeting Proceedings 2013; 31, No 15_suppl (May 20 Supplement): 4053. Martin R. Stockler, Felix Hilpert, Michael Friedlander, Madeleine King, Lari B. Wenzel, Chee Lee, Florence Joly, Nikolaus De Gregorio, Jose Angel Arranz Arija, Mansoor Raza Mirza, Roberto Sorio, Ulrich Freudensprung, Vesna Sneller, Gill Hales, Eric Pujade Lauraine and AURELIA Investigators. Health-related quality of life (HRQoL) results from the AURELIA trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum-resistant recurrent ovarian cancer (OC). ASCO Annual Meeting Proceedings 2013, 31 May-4 June 2103 Chicago, USA. Angelina Tjokrowidjaja, Chee Lee, Martin R. Stockler. Does chemotherapy improve survival in muscle-invasive bladder cancer (MIBC)? A systematic review and metaanalysis (MA) of randomized controlled trials (RCT). Journal of Clinical Oncology, ASCO Annual Meeting Proceedings 2013; 31 May-4 June 2103 Chicago, USA. Chee Khoon Lee, Alan Coates, Malcolm Hudson, Karin Ribi, Jürg Bernhard. Prognostic significance of qualityof-life scores in early stage and relapsed breast cancer: results from seven randomized trials of the International Breast Cancer Study Group. SABCS 2013. San Antonio Breast Cancer Symposium 10-14 December 2013 San Antonio, Texas USA. 68 Angelina Tjokrowidjaja, Chee K Lee, Nehmat Houssami, Sally J Lord. Metastatic breast cancer (MBC) in young women: A population-based cohort study to describe risk, characteristics and prognosis. SABCS 2013. San Antonio Breast Cancer Symposium 10-14 December 2013 San Antonio, Texas USA. Chee Khoon Lee, Lucy Davies, Val Gebski, Sally Lord, Angelo Di Leo, Stephen Johnston, Charles Geyer Jr, David Cameron, Michael Press, Catherine Ellis, John Simes, Paul De Souza. HER2 Extracellular Domain (ECD): A Predictive Marker of Lapatinib Treatment Benefit in Advanced Breast Cancer. SABCS 2013. San Antonio Breast Cancer Symposium 10-14 December 2013 San Antonio, Texas USA. Fox, P., B. Gao, B. Balakrishnar, A. M. Menzies, V. Gebski, S. Coulter, C. Liddle, R. Hui, R. Kefford, J. Lynch, N. Wilcken, R. L. Balleine and H. Gurney (2013). Factors predicting endoxifen level in a tamoxifen dose escalation study of breast cancer patients. ASCO. 31 May-4 June 2103 Chicago, USA. Kirby, R., N. Alzahrani, J. Zhao, T. Chua, W. Liauw and D. Morris (2013). P-0153 Peritonectomy results at St George Hospital, Sydney Australia at 677 Procedures (Poster). ESMO 15th World Congress on Gastrointestinal Cancer, 3–6 July 2013, Barcelona, Spain. > Department of Palliative Care, St George Hospital & Calvary Health Care Sydney Head of Department Dr. Jan Maree Davis B.Med (Hons) FRACP FAChPM Senior Medical Dr. Frank Brennan MB BS FRACP FAcHPM Dr. Judith Lacey MBBS FRACP FAcHPM Dr. Christine Sanderson BA, BMBS, MPH, FRACP Dr Linda Sheahan, Staff Specialist FRACP, M. Bioethics Research Professor Elizabeth Lobb PhD., MAppSci, B.AdEd. Professor of Palliative Care (Allied Health), Calvary Health Care Sydney and Cunningham Centre for Palliative Care; Adjunct Professor, School of Medicine, the University of Notre Dame, Sydney. Dr. Christine Sanderson, BA, BMBS, MPH, FRACP Staff Specialist in Palliative Medicine, Calvary Health Care Sydney; Research Fellow, CareSearch, Flinders University of South Australia, PaCCSC (Palliative Care Clinical Studies Co-operative Investigator Dr. Jane Mowll PhD, Research Associate Ms. Lesley White, RN Ms. Louise Bryce, RN Ms. Victoria Tait, RN Ms Mary Heidenreich RN Ms. Anne Johnson, Senior Social Worker Research Grants Australian Government DIISR Research Collaborative Research Network, University of Notre Dame Phillips J and Lobb EA. Palliative Care: Translating evidence into action to improve outcomes for palliative care patients and their care givers. 2013 – 2017. $760,000. Australian Government, DIISR Collaborative Research Network, University of Notre Dame Monterosso L, Lobb EA, Bulsara M. The effect of a nurse-led haematology survivorship clinic on patient reported anxiety and unmet informational needs: a multi-site Phase II randomised controlled trial. 2013 – 2017 $494,774. Cancer Council WA. Halkett GKB, Nowak A, Lobb EA, Agar M, Miller L, Moorin R, Shaw T. Confidence to Care: Pilot of a structured home-based support and education for caregivers of people with high grade glioma. 20132014, $99,315. Cancer Institute NSW. Sanderson C, Lobb EA, Upfront Family Meetings for Community Palliative Care Services. Evidence to Practice Grant 2013-2014. $50,000. Cancer Institute NSW. Innovation Grant Lobb EA, Hanson S, Sanderson C, Links M, Liauw W. Retrospective case review and analysis of clinical journey of 100 consecutive deaths in the Oncology Unit at St. George Hospital, 2013 $25,000. Cancer & palliative Care Research & Evaluation Unit – University of Western Australia. Monterosso L, Lobb EA, Joske, D, White K, Young, K, Platt V, Krishnasamy, M, Yates P, Johnson C. Defining unmet needs of haematology survivors: An exploratory study to inform intervention development. 2012. $19,985. Churchill Fellowship, Sheahan, L. Exploring the Interface between Palliative Care and Legalised Physician Assisted Dying. 2012 $20000. St. George Hospital Cancer Care Centre, Lobb EA, Lane L, Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, Liauw W, Mason C, Ingham J, Garrard J. A pilot study of an intervention to facilitate communication between couples on end-of-life issues.. 2012-2013. $42,000. Cancer Institute NSW, Agar M (CI), Davidson P, Clark K, Phillips J, Xuan W, Sanderson C, Lobb E, Lovell M, Luckett T, Clayton J, Chye R, Liauw W, Chang S, Hardy J (AIs). Improving Palliative Care through Clinical Trials (ImPaCCT) - the NSW collaborative trials group in palliative care. Cooperative Clinical Trial Grant. 2013-2016. $295,484. Mary Philippa Brazill Foundation, Phillips JL, Lobb EA, Lynch S, Ingham J. A study to build the capabilities of Australian undergraduate medical and nursing students to respond to requests to hasten death.. 2013. $4,000 Research Projects in Progress A pilot study of an intervention to facilitate communication between couples on end-of-life issues Lobb EA, Lane L, Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, Liauw W, Mason C, Ingham J, Garrard J. Pilot of a structured home-based support and education for caregivers of people with high grade glioma. Halkett GKB, Nowak A, Lobb EA, Agar M, Miller L, Moorin R, Shaw T. 69 Too much, too soon? The impact of treatment-focused genetic testing in patients newly diagnosed with breast cancer. CIs Meiser B, Mitchell G, Tucker K, Saunders C, Geelhoed E, Hopper J, Watts K. AIs: Kirk J, Lobb EA, Barlow-Stewart K, Friedlander M, Thewes B, Southey M, Gleeson M, Kelly P. Palliative Care: Translating evidence into action to improve outcomes for palliative care patients and their care givers. Phillips J and Lobb EA. The effect of a nurse-led haematology survivorship clinic on patient reported anxiety and unmet informational needs: a multi-site Phase II randomised controlled trial. Monterosso L, Lobb EA, Bulsara M. Confidence to Care: Pilot of a structured home-based support and education for caregivers of people with high grade glioma. Halkett GKB, Nowak A, Lobb EA, Agar M, Miller L, Moorin R, Shaw T. Upfront Family Meetings for Community Palliative Care Services. Sanderson C, Lobb EA. Retrospective case review and analysis of clinical journey of 100 consecutive deaths in the Oncology Unit at St. George Hospital. Lobb EA, Hanson S, Sanderson C, Links M, Liauw W. Defining unmet needs of haematology survivors: An exploratory study to inform intervention development. Monterosso L, Lobb EA, Joske, D, White K, Young, K, Platt V, Krishnasamy, M, Yates P, Johnson C. A pilot study of an intervention to facilitate communication between couples on end-of-life issues. Lobb EA, Lane L, Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, Liauw W, Mason C, Ingham J, Garrard J. Improving Palliative Care through Clinical Trials (ImPaCCT) - the NSW collaborative trials group in palliative care. Agar M (CI), Davidson P, Clark K, Phillips J, Xuan W, Sanderson C, Lobb, E, Lovell M, Luckett T, Clayton J, Chye R, Liauw W, Chang S, Hardy J (AIs). A study to build the capabilities of Australian undergraduate medical and nursing students to respond to requests to hasten death. Phillips JL, Lobb EA, Lynch S, Ingham J. Who grieves: identifying those most likely to be affected by the death of a person with a terminal condition. Phillips J, Currow D, Lobb EA. Exploring the Interface between Palliative Care and Legalised Physician Assisted dying – Cross sectional Data collection from the Australian and New Zealand context. Sheahan L. 70 Original Peer-Reviewed Publications 2012 Brennan FP. John Keats and Wilfred Owen – Mortality, Mystery, and the Pursuit if Truth: Lessons for Palliative Care. Journal of Palliative Care 2012; 28(2): 116-119. Brennan FP. The lonely impulse of delight. Journal of Palliative Care 2012; 28(4): 297-300. Josland E, Brennan FP, Anastasiou A, Brown MA. Developing and sustaining a renal supportive care service for people with end-stage kidney disease. Renal Society of Australasia Journal 2012; 8(1): 12-18. Lobb, EA. The challenge of giving bad news. Medicine Today 2012, Vol 13 (9).55-57. Invited paper. Rando, T.A., Doka, K.J., Fleming, S., Franco, M.H., Lobb, EA., Murray Parkes, C. Steele, R. A Call to the Field, Omega – Journal of Death & Dying, 2012. 64 (4); 251255. Invited paper. Butow,PN, Lobb, EA, Jefford, M, Goldstein, D., Eisenbruch, M., Girgis, A., King, M., Sze, M., Aldridge, LJ, Schofield, P. A bridge between cultures: interpreters’ perspectives of consultations with migrant oncology patients. Supportive Care in Cancer, 2012. 20(2):235 – 244. Hudson, P., Lobb, EA, Thomas. K., Zordan, R., Trauer, T., Quinn, K., Williams, A., Summers, M. Psycho-educational group intervention for family caregivers of hospitalised palliative care patients: pilot study. Journal of Palliative Medicine 15 (3) 277-281. 2012. Zilliacus E, Meiser B, Gleeson M, Watts K, Tucker K, Lobb EA, Mitchell G Are we being overly cautious? A qualitative inquiry into the experiences and perceptions of treatmentfocused germline BRCA genetic testing amongst women recently diagnosed with breast cancer Supportive Care in Cancer (2012) 20(11):2949-58. Halkett, G., Kristjanson, L., Lobb, EA., Little, J., Jiwa, M., Shaw, T., Taylor, M.,Spry, N. Information needs and preferences of women as they proceed through radiation therapy for breast cancer. Pt Edu & Couns, 2012;86(3):396404. Hudson, P., Trauer, T., Lobb, EA., Williams, A., Zordan, R., Quinn, K., Williams, A., Summers, M. Supporting family caregivers of hospitalized palliative care patients: Effectiveness of a psycho-educational group intervention. BMJ Supportive & Palliative Care (2012). doi:10.1136/ bmjspcare-2011-000131. Coupe NA, Lacey J, Sanderson C. Unique Manifestations of Catecholamine Release in Malignant Pheochromocytoma: An Experience Within an Inpatient Palliative Care Unit. J Pain Symptom Manage. 2012 May;43(5):967-72. Newton PJ, Davidson PM, Sanderson C. An online survey of Australian physicians reported practice with the off-label use of nebulised frusemide. BMC Palliative Care 2012, 11:6. Sheahan L, Da Silva M, Czoli C, Zlotnik Shaul R. A Canadian Perspective on a Child’s Consent to Research within a Context of Family Centered Care: From Incompatibility to Synergy. Journal of Clinical Research and Bioethics 2012: 3 (1). 2013 Brennan FP. “Clock Without Hands” – Carson McCullers and the Rhythm of Living and Dying. American Journal of Hospice and Palliative Medicine 2013; 30(3):312-316. Urban K, Brennan FP. Patients who withdraw from dialysis in a Sydney centre with palliative care support : who, why, and how they die. Progress in Palliative Care. 2013; 21(6): 325-330. Brennan FP. Conscientious Objector – Edna St Vincent Millay, mortality and the nature of Palliative Care. Journal of Palliative Care 2013; 29(2): 123-125. Brennan FP, Brown M. The ethics of dialysis – an alliance of Nephrology, Palliative Medicine and Ethics. Quarterly Journal of Medicine 2013; 106(5): 397-400. Brennan FP. The New World of Ourselves. Journal of Palliative Care. 2013; 29(4): 258-259. Brennan FP. Ethical Principles for Patients, Families and Doctors to Consider. Nephrology 2013; 18: 413-414. Brennan FP, Siva B, Crail S. Appropriate Assessment of Symptom Burden and Provision of Patient Information. Nephrology 2013; 18: 418-421. Brennan FP. Holistic Palliative Care Approach - Physical, Spiritual, Religious and Psychological Needs. Nephrology 2013;18: 421-423. Siva B, Brennan FP. Inappropriate Interventions in the Dying Patient. Nephrology 2013; 18: 423-424. Stewart C, Brennan FP. Legal Issues Concerning Withholding and Withdrawal of Dialysis. Nephrology 2013; 18: 444-449. Lim CED, Siow S, Ho KEH, Chua JL, Chong N, Cheng L, Kwok, Brennan FP, Cigolini M. Advance Care planning in haemodialysis patients. Protocol Information. Cochrane Reviews. Review number 294. September 2013. Brennan FP, Murrell DF. Report from the Inaugural Australian Pruritus Symposium, Sydney, Australia, August 10 2013. Acta Derm Venereol 2013. Oct 24 [Epub ahead of publication]. Kearsley, JH, Lobb, EA. “It’s not a disease we treat but a person:” Reflections of medical students from their first rotation to an oncology and palliative care unit. Journal of Palliative Care. 29:3 / 2013; 231–235. Lobb, EA, Lacey, J., Kearsley, J., Liauw, W., White, L., Hosie, A. Living with advanced cancer and an uncertain disease trajectory: An emerging population in palliative care? BMJ Supportive & Palliative Care. Published on-line April 2013; 2013;0:1–6. doi:10.1136/ bmjspcare-2012-000381 Watts, K.J., Meiser, B., Wakefield, C., Barratt, A., Howard, K., Cheah, B.C., Mann, G.J., Lobb, EA, Gaff, C.L., Patel, M.I. Online prostate cancer screening decision aid for at-risk men: A randomized trial, Health Psychology, 12 June 2013.Patel MI. Health Psychology, Health Psychology 11/2013, DOI:10.1037/a0034405. Sanderson, C., Lobb, EA, Mowll, J. Butow, P., Price, M. Signs of post-traumatic stress disorder in caregivers following an expected death: a qualitative study’ as a factual descriptor of the study. Palliative Medicine, 2013, 27(7), 625-631. Sanderson C, Hardy J, Spruyt O, Currow D Placebo and nocebo effects in randomised controlled trials - the implications for research and practice. Journal of Pain and Symptom Management: Vol. 46 No. 5 November 2013. Heidenreich MT, White K, Kuen Koo F The experience of Chinese immigrant women in caring for a terminally ill family member in Australia, Collegian 03 July 2013 (10.1016/j.coleg.2013.06.002). Other published material 2012 Lobb, EA. Chapter: “The selfsame well: Perspectives on human suffering in loss, grief and bereavement”. Book – Perspectives on Human Suffering, proceedings from Colloquium on Human Suffering, Hobart, February 2012. Elservier. Editors J. Malpas and N. Lickiss, C. Sanderson. Sanderson, C. Webpage for CareSearch. Dementia (including evidence summaries on palliative care challenges; caregivers and care settings; prognosis and advance care planning; symptom management.) http:// www.caresearch.com.au/caresearch/tabid/2785/Default. aspx, accessed May 29, 2013. Brennan FP. Renal Palliative Care – A Reader. 2012. Vision Media, Sydney. Brennan FP. Suffering seeks a voice. In: Malpas J and Lickiss N (eds). Perspectives on Human Suffering. 2012. Springer Publishing. 71 Presentations at Scientific Meetings and Conferences 2012 – International Lobb, EA, Price, M., McGowan, N., Mowll, J Butow, PN. “Palliative care services and a ‘good death’; learning from family care-givers” 19th International Congress on Palliative Care, Montreal 9-12 October Kearsley, J & Lobb, EA. “It is not a disease we treat but a person”: Reflections of medical students on their first rotation to an oncology and palliative care term”. 19th International Congress on Palliative Care, Montreal 9-12 October, 2012 Lobb, EA, Price, M., McGowan, N., Mowll, J Butow, PN. “Palliative care services and a ‘good death’; learning from family care-givers” 19th International Congress on Palliative Care, Montreal 9-12 October. Hudson, P, Trauer, T, Lobb, EA, Zordan, R. Williams, A., Quinn, K., Summers, M., Thomas, K., Supporting family caregivers of hospitalized palliative care patients: A psycho-educational group intervention. 19th International Congress on Palliative Care, Montreal 9-12 October. Brennan, FP. The management of pain and other symptoms in patients with End Stage Kidney Disease. Australian and New Zealand Society of Nephrology Meeting, Auckland, New Zealand, August 26. Heidenreich MT, White K, Kuen Koo F. Caring Is a Lonely and Isolating Experience: Immigrant Chinese Women’s Experience in Caring for a Terminally Ill Relative at Home in New South Wales, Australia. 19th International Congress on Palliative Care. Montreal, Canada. October. 2012 – National Mowll, J., Lobb, EA, Price, M., McGowan, N., Butow, PN. Features of gender and grief reported in the experiences of family care-givers six months after a family member’s death from ovarian cancer. Clinical Oncological Society of Australasia Annual Scientific Meeting, Melbourne Halkett, G., Nowak, A., Lobb, EA, Long, A. Fournier, C., Nowak, A. Carers of patients with HGG are more distressed than the patients: Understanding the experience of caring for people living with High Grade Glioma Clinical Oncological Society of Australasia Annual Scientific Meeting, Melbourne. Calford, BR, Zilliacus, E., Meiser, B., Lobb, EA, Spigelman, A, Tucker, K. The Process and Content of Tele-health Cancer Genetic Counselling, Clinical Oncological Society of Australasia Annual Scientific Meeting, Melbourne. Zordan, R., Remedios, C., Price, M., Lobb, EA, Hall, C., Hudson, P. The prevalence and predictors of threshold and 72 sub-threshold prolonged grief disorder (PGD) amongst bereaved cancer caregivers: Implications for bereavement services Clinical Oncological Society of Australasia Annual Scientific Meeting, Melbourne. Brennan, FP. Palliative Care Physicians don’t just palliate. Renal Home Therapies Conference, Sydney. March 15. Brennan, FP. How Do We Stop ? Withdrawal From Dialysis. Renal Home Therapies Conference, Sydney. March 15. Brennan, FP. Renal Supportive Care – An Overview and Recent Developments. NSW Palliative Care Education Day, Royal Prince Alfred Hospital. May 25. Brennan, FP. Symptom management in patients with Chronic Kidney Disease. Renal Supportive Care Symposium, St George Hospital. August 10. Brennan, FP. Nephrology- Medical, Ethical and Legal Dimensions. Renal Supportive Care Symposium, St George Hospital. Case based discussion with Dr Su Crail, Professor Cameron Stewart and Bernadette Tobin. August 10. Brennan, FP.. What is new in Renal Supportive Care ? (Copresented with Liz Josland and a video presentation by Gemma Collett) August 10. Brennan, FP..Symptom management in patients with Chronic Kidney Disease. Renal Supportive Care Symposium, St George Hospital. August 10. 2013 - International Lobb, EA, Lane, L., Lacey, J., Chochinov, HM, Kelly, B. Agar, M., Mowll, J., Links, M., Kearsley, JH, Liauw, W., Lynch, J. A pilot study of an intervention for couples to facilitate communication about end of life issues where one member of the couple has incurable cancer. 15th World Congress on Psycho-oncology, Rotterdam, 4-8th November (oral). Sanderson, C, Lobb, EA, Mowll, J, Butow, PN, McGowan, N., Price, MA. The sights and sounds of palliative care: Caregivers’ experiences at the deathbed: A qualitative study. 15th World Congress on Psycho-oncology, Rotterdam, 4-8th November. (poster) Lobb, EA, Lacey, J, Liauw, W, White, L., Hosie, A, Kearsley, J. A re-assessment of meaning-making in patients with early-diagnosed incurable cancer. 15th World Congress on Psycho-oncology, Rotterdam, 4-8th November. Hosie, A., Phillips, J., Agar, M., Lobb, EA, Davidson, P. Exploring recognition and assessment of delirium symptoms by palliative care nurses using the Critical Incident Technique. 8th Annual Meeting of the European Delirium Association; Leuven, Belgium, September 20-21 (oral). Brennan FP, Palliative Care in End Stage Renal Disease. Asia Pacific Hospice and Palliative Care Network Conference, Bangkok, Thailand. October 11. Brennan FP, Renal Supportive Care in adult patients – An Overview . Paediatric Palliative Care Symposium, Westmead Childrens’ Hospital. March 7. Brennan FP,. Engaging Palliative care in non-cancer patients. Asia Pacific Hospice and Palliative Care Network Conference, Bangkok, Thailand. [Plenary speech] October 12. Brennan FP, The experience of establishing a Renal Supportive Care Service. Nephrology Scientific Symposium. Melbourne, Victoria. April 20. Brennan FP, Morality and Ethics in the withdrawal of treatment. Asia Pacific Hospice and Palliative Care Network Conference, Bangkok, Thailand. October 13. Brennan FP, Renal Supportive Care – An Overview. All Ireland Palliative Care Institute, Dublin, Ireland. April 29. 2013 National Lobb, EA, Sanderson, C, Mowll, J., Butow, PN, Price, M. “The Sights and Sounds of Palliative Care” Caregiver’s experiences at the deathbed: A qualitative study”. 12th Australian Palliative Care Conference National Convention Centre in Canberra, 3-6 September. Sanderson, C., Johnson, A., Lobb, EA, Mowll, J. “Do early patient-centered family meetings reduce patient and family distress at first admission for in-patient palliative care”? 12th Australian Palliative Care Conference the National Convention Centre in Canberra, 3-6 September. Hosie, A., Phillips, J., Agar, M., Lobb, EA, Davidson, P. Exploring recognition and assessment of delirium symptoms by palliative care nurses: a qualitative study”. 12th Australian Palliative Care Conference, National Convention Centre in Canberra, 3-6 September. Sanderson, C., Johnson, A., Lobb, EA, Mowll, J. Studying family meetings: what have we learned and what should we measure? 12th Australian Palliative Care Conference to be held at the National Convention Centre in Canberra, 3-6 September. Kadwell, L., Usher, J., Gilbert, E, Lobb EA. “Talking about sexuality and intimacy is everyone’s business” Health professionals communication in the context of cancer and palliative care” 12th Australian Palliative Care Conference, National Convention Centre in Canberra, 3-6 September. Sheahan, L., Churchill Fellowship report findings: Exploring the Interface between Palliative care and Legalised Physician. Assisted Suicide/Voluntary Euthanasia. Palliative Care Australia Conference, Canberra, August. Brennan FP, Renal Supportive Care – An Overview. Department of Nephrology, John Hunter Hospital, Newcastle. February 14. Brennan FP, Pain in non-malignant diseases including End Stage Kidney Disease. Pain Symposium. Pain Institute Royal North Shore Hospital, Sydney. May 4. Brennan FP, Renal Supportive Care – An Overview. The Physicians’ Forum. Concord Hospital, Sydney, July 11. Brennan FP, What is new in Renal Supportive Care? Renal Supportive Care Symposium, St George Hospital, Sydney, August 9. Brennan FP, The pathogenesis and management of Restless Legs Syndrome. Renal Supportive Care Symposium, St George Hospital, Sydney, August 9. Brennan FP, The pathogenesis of pruritus. Pruritus Symposium. St George Hospital, Sydney. August 10. Brennan FP, The pathogenesis and management of Uraemic Pruritus. Pruritus Symposium. St George Hospital, Sydney, August 10. Brennan FP, Management and Advance Care Planning in patients with End Stage Kidney Disease. Clinical Ethics Forum - Ethics, End of Life and Advance Care Planning. Royal Hospital for Women, Randwick, Sydney. September 27. Heidenreich MT, White K, Kuen Koo F Caring Is a Lonely and Isolating Experience: Immigrant Chinese Women’s Experience in Caring for a Terminally Ill Relative at Home in New South Wales, Australia. 12th Australian Palliative Care Conference. Canberra, ACT, 3-6 September. Heidenreich MT, White K, Kuen Koo F. Chinese family obligations: Confucian cultural beliefs influencing palliative care for Chinese families and female carers in Australia. 12th Australian Palliative Care Conference. Canberra, ACT, 3-6 September. Community Engagement Lobb, EA. Appointed to Executive Committee of ACI Palliative Care Network 2012. Lobb, EA. Appointed member of Expert Advisory Group on Bereavement Search filter – CareSearch, 2012. Kearsley, J., Lacey, J., Lobb, EA, Sanderson, C., White, L. Organising Committee – Whole Person Care Public Lecture – Professor Eric Cassell, UNSW, 2nd September, 2013. 73 Kearsley, J., Lacey, J., Lobb, EA, Sanderson, C., White, L. Organising Committee – Whole Person Care Symposium, Sydney, May, 2012. 74 > Department of Radiation Oncology Professor J H Kearsley MBBS (Hons Syd) FRACP FRANZCR Junli (Cindy) Deng PhD student Ning (Sophia) Li Visiting Fellow (Medical Oncologist) Oliver Fio ILP student Senior Medical Allied Health A/Professor Peter Graham MBBS, FRANZCR, Cert Bioethics, Grad Dip Medical Statistics Dr Joseph Bucci MBBS FRACP FRANZCR Dr Catherine Clark MBBS FRANZCR Dr Yaw Chin BSc (Med) FRANZCR Dr Eric Hau BSc (Med), MBBS, Grad Cert (Biostat), FRANZCR Julia Maclean PhD M.Sc (Medicine) B.App. Sc (Speech Pathology), BA (Linguistics/Psychology) Wendy Relf, M. HealthSc (Comms), B.App. Sc (Speech Pathology), BA (Linguistics/Psychology). Head of Department Junior Medical Dr Nadine Beydoun Dr Eric Hau Dr Ariyanto Pramana Dr Mimi Tieu Dr Dominique Lee Dr Alex Petruvski Dr Chelsea Connor Research Staff - Clinical Trials Unit Peter Fink BSc, Clinical Trials Unit Manager –Radiation Oncology Trials Co-ordinators Helen Cox BSc Sima Don PhD Faith Koh MPH Mary MacFarlane RN Kylie Melki - BBioTech Sharon Parkes BSc Xiaolu Wang M HealthAdmin Xiaobing Ma BMed Victoria Stevens BPharm Senior Researchers A/Professor Yong Li: Principal Scientific Officer and Head of Cancer Research Program Dr Jingli (Helen) Hao: Hospital Scientist, Conjoint Lecturer of UNSW Research Students Julia Beretov Scientific Officer and PHD student Lei (Nancy) Chang PhD student Research Grants NHMRC Project Grant, Principal Investigators: Cook I, Szczesniak M, Maclean J, Graham P, Omari T. Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy. $301,624 (2012-2014). NHMRC Career Development Fellow (Level 2) Principal Investigators: A/Professor Yong Li Identification of novel biomarkers in urine to improve diagnosis and monitor progression in prostate cancer. $417,000 (2010-2014). ARC-linkage Grant Principal Investigators: A/Professor Yong Li, Dr Paul Cozzi, M. Willcox, B. Walsh. Proteomic study of urine to discover novel biomarkers for human prostate cancer. $150,000 (2010-2013). Cancer Australia / National Breast Cancer Foundation, Principal Investigators: Holloway L, Metcalfe P, Lazarus E, Delaney G, Batumalai V, Vial P, Koh E-S, Associate Investigators: Quinn A, Jameson M, Hargreaves B, Moran C, Keall P, Collins L, Shafiq J, Rozenfeld A, Lonergan D, Papadatos G, Lim K, Ahern V, Drummond R, Tiver K, Graham P, Ramsay J. Breast MRI in radiotherapy planning. $391,596 2012-2015. Cancer Australia Project Grant, Principal Investigators: A Prof P Graham, Prof G Delaney, Dr E Millar, Dr Anne Capp. AIs: Prof R Sutherland, Dr S Carroll, Dr J Harvey, Dr J Lynch , Dr R Tse. TROG 08.06; A randomised comparison of anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. (STARS - Study of Anastrozole and Radiotherapy Sequencing), $660,000 (2010-2012). 75 Research Projects in Progress A randomised comparison of Anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus Anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. Principal Investigator: A/Professor Peter Graham. Determining the needs of Grade III-IV High Grade Glioma patients. Principal Investigator: Professor John Kearsley. A collaborative randomised phase III trial: The timing of intervention with androgen deprivation in prostate cancer patients with a rising PSA. Principal Investigator: Dr Joseph Bucci. Randomised trial investigating the effect on survival and PSA control of different durations of adjuvant androgen deprivation in association with definitive radiation treatment for localised carcinoma of the prostate (RADAR). Principal Investigators: Dr Joseph Bucci. A phase III study of regional RT in early breast cancer (NCIC MA20). Principal Investigator: A/Professor Peter Graham. STARS Pilot Breast Trial: A randomised comparison of Anatrazole commenced before and continues during radiotherapy for breast cancer versus Anastrazole and subsequent Anti-Oestrogen therapy delayed until after radiotherapy. Principal Investigator: A/Professor Peter Graham. A randomised comparison of breast conservation with or without lumpectomy radiotherapy boost Principal Investigator: A/Professor Peter Graham Pulmonary Fibrosis following breast conservation adjuvant radiotherapy: the modifying effects of systemic therapies (chemotherapy and Tamoxifen. Principal Investigator: A/ Professor Peter Graham. A Randomised Phase III Study of Radiation Doses and Fractionation Schedules in Non-Low Risk Ductal Carcinoma In Situ (DCIS) of the Breast. Principal Investigator: A/ Professor Peter Graham. A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer. Principal Investigator: Dr Yaw Chin. RAVES: Radiotherapy - Adjuvant Versus Early Salvage. A phase III multi-centre randomised trial comparing adjuvant radiotherapy (RT) with early salvage RT in patients with positive margins or extraprostatic disease following radical prostatectomy. Principal Investigator: Dr Joseph Bucci. Phase II Study of Accelerated Partial Breast Irradiation Using Interstitial Multi-Catheter High Dose Rate Brachytherapy. Principal Investigator: Dr Yaw Chin. 76 Feasibility of Using Polyethylene Glycol Hydrogel to Increase Prostate-Rectum Separation and Its Impact on Rectal Dose during Radiation Therapy. Principal Investigator: Dr Nadine Beydoun. Evaluating the Utility of a Patient Decision Aid for Prospective Participants in the TROG RAVES Prostate Cancer Trial (TROG 08.03) Principal Investigator: Dr Joseph Bucci. A Phase II Study of Stereotactic ablative Body Radiotherapy(SABR) for Stage I NSCLC. Principal Investigator: Dr Eric Hau. Identification of novel biomarkers in tears for breast cancer diagnosis and monitoring. Principal Investigators: A/ Professor Yong Li, A/Professor Peter Graham, M Willcox , V Wasinger and Professor John Kearsley . PI3K/Akt/mTOR signalling pathway in prostate cancer radioresistance. Principal Investigators: A/Professor Yong Li, A/Professor Peter Graham, Professor John Kearsley and Dr Joseph Bucci. Identification of novel biomarkers associated with prostate cancer radioresistance. Principal Investigators: A/Professor Yong Li, A/Professor Peter Graham, Dr Paul Cozzi, Professor John Kearsley and Dr Joseph Bucci. Investigating the roles of CD44v6 and CD326 in prostate cancer metastasis and chemo- radioresistance. Principal Investigators: A/Professor Yong Li, Dr Paul Cozzi, A/ Professor Peter Graham, and Professor John Kearsley. Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy. Principal Investigators: Professor Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean, A/Professor Peter Graham, Dr Taher Omari. Prospective, randomized controlled trial of cricopharyngeal dilatation in postlaryngectomy dysphagia. Principal Investigators: Dr Peter Wu, Professor Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean. Influence of Altered Pharyngo-esophageal Biomechanical Parameters on Swallowing and Speech Function in Laryngectomees. Principal Investigators: Ms Teng Zhang, Professor Ian Cook, Dr Michal Szczesniak, A/Prof Paul Bertrand, Dr Julia Maclean. Original Peer-Reviewed Publications 2012 Beydoun, N., Graham, P. H., & Browne, L. (2012). Metastatic cutaneous squamous cell carcinoma to the axilla: A review of patient outcomes and implications for future practice. World Journal Oncology, 3(5), 217-226. Graham, P., Plant, N., Graham, J., Browne, L., Borg, M., Capp, A., Delaney, G., Harvey, J., Kenny, L., Francis, M., & Zissiadis, Y. (2012 ). Digital photography as source documentation of skin toxicity: An analysis from the Trans Tasman Radiation Oncology Group (TROG) 04.01 Post-Mastectomy Radiation Skin Care. Journal of Medical Imaging and Radiation Oncology, 56, 458-463. Hao, J., Madigan, M. C., Khatri, A., Power, C. A., Hung, T.-T., Beretov, J., Chang, L., Xiao, W., Cozzi, P. J., Graham, P. H., Kearsley, J. H., & Li, Y. (2012). In Vitro and In Vivo Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147. PLoS ONE, 7(8), e40716. Hau, E., Browne, L. H., Khanna, S., Cail, S., Chin, Y., Clark, C., Inder, S., Szwajcer, A., & Graham, P. (2012). Radiotherapy Breast Boost With Reduced Whole-Breast Dose Is Associated With Improved Cosmesis: The Results of a Comprehensive Assessment From the St. George and Wollongong Randomized Breast Boost Trial. International Journal of Radiation Oncology Biology Physics, 82(2), 682689. Hau, E., & Graham, P. (2012). A brief review on the biological effects of radiation on cells. The Radiographer, Volume 59(3), 89-97. Kearsley, J. (2012). An exquisite presence (after Buber). Palliative & Supportive Care, 10(04), 307-307. Ni, J., Cozzi, P., Duan, W., Shigdar, S., Graham, P., Kearsley, J., & Li, Y. (2012). Role of the EpCAM (CD326) in prostate cancer metastasis and progression. Cancer and Metastasis Reviews, 31(3-4), 779-791. Pramana, A., Browne, L., & Graham, P. H. (2012). Metastatic cutaneous squamous cell carcinoma to parotid nodes: The role of bolus with adjuvant radiotherapy. Journal of Medical Imaging and Radiation Oncology, 56(1), 100-108. Xiao, W., Graham, P., Power, C., Hao, J., Kearsley, J., & Li, Y. (2012). CD44 is a biomarker associated with human prostate cancer radiation sensitivity. Clinical and Experimental Metastasis, 29(1), 1-9. Xiao W, Graham P, Power C, Hao JL, Kearsley J, Li Y. CD44 is biomarker correlated with human prostate cancer radiation sensitivity. Clinical & Experimental Metastasis 2012; 29:1-9. Shigdar S, Lin J, Li Y, Yang CJ, Wei M, Zhu Y, Liu H, Duan W. Cancer stem cell targeting: the next generation of cancer therapy and molecular imaging. Therapeutic Delivery 2012; 3:227-244. Hao J, Madigan M, Khatri A, Power C, Hung T, Beretov J, Chang L, Xiao W, Cozzi P, Graham P, Kearsley J, Li Y. In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147. PLoS ONE 2012;7:e40716. Ni J, Cozzi PJ, Duan W, Shigdar S, Graham P, Kearsley J, Li Y. Role of the EpCAM (CD326) in prostate cancer metastasis and progression. Cancer and Metastasis Reviews 2012; 31:779-791. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J, Li Y. Epithelial mesenchymal transition (EMT) is involved in the prostate cancer radiation resistance. Asia-Pacific Journal of Clinical Oncology 2012; 8(Supplement 3): 333. 2013 Ball, D. L., R. J. Fisher, B. H. Burmeister, M. G. Poulsen, P. H. Graham, M. G. Penniment, S. K. Vinod, H. E. Krawitz, D. J. Joseph, G. C. Wheeler and B. E. McClure (2013). The complex relationship between lung tumor volume and survival in patients with non-small cell lung cancer treated by definitive radiotherapy: A prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05). Radiotherapy and Oncology 106(3): 305-311. Beydoun, N., Bucci, J., Chin, Y., Spry, N., Newton, R., and Galvão, D., (2013). Prospective study of exercise intervention in prostate cancer patients on androgen deprivation therapy. Journal of Medical Imaging and Radiation Oncology: epub, DOI: 10.1111/17549485.12115. Chao, H., Wang, L, Hao, J, Ni, J, Chang, Li, Graham, P, Kearsley, J and Li, Y (2013). Low dose histone deacetylase inhibitor, LBH589, potentiates anticancer effect of docetaxel in epithelial ovarian cancer via PI3K/Akt pathway in vitro. Cancer Letters 329(1): 17-26. Chao, H., Wang, L, Hao, J, Ni, J, Chang, Li, Graham, P, Kearsley, J and Li, Y (2013). Low dose histone deacetylase inhibitor, LBH589, potentiates anticancer effect of docetaxel in epithelial ovarian cancer via PI3K/Akt pathway in vitro. Cancer Letters 329(1): 17-26. Graham, P, Plant N, Graham J, L. Browne, M. Borg, A. Capp, G. P. Delaney, J. Harvey, L. Kenny, M. Francis and Y. Zissiadis (2013). A Paired, Double-Blind, Randomized Comparison of a Moisturizing Durable Barrier Cream to 10% Glycerine Cream in the Prophylactic Management of Postmastectomy Irradiation Skin Care: Trans-Tasman Radiation Oncology Group (TROG) 04.01. International Journal of Radiation Oncology Biology*Physics 86(1): 4550. Hao, J., Ni, J, Graham, P, Cozzi, P, Bucci, J. Kearsley, J and Li, Y (2013). “The CD44 Isoforms in Prostate Cancer Metastasis and Progression. World Journal of Cancer Research 1(1): 3-14. Hau, E, Browne L., Capp A., Delaney G. P, Fox, C, Kearsley, J, Millar, E. Nasser, E, Papadatos G and Graham, 77 P (2013). The impact of breast cosmetic and functional outcomes on quality of life: long-term results from the St. George and Wollongong randomized breast boost trial. Breast Cancer Research and Treatment: 1-9. Haworth, A., L. Wilfert, D. Butler, M. A. Ebert, S. Todd, J. Bucci, G. M. Duchesne, D. Joseph and T. Kron (2013). Australasian brachytherapy audit: Results of the ‘end-toend’ dosimetry pilot study. Journal of Medical Imaging and Radiation Oncology: Volume 57, Issue 4, pages 490–498, August 2013. Lobb, E. A., J. Lacey, J. Kearsley, W. Liauw, L. White and A. Hosie (2013). “Living with advanced cancer and an uncertain disease trajectory: an emerging patient population in palliative care?” BMJ Supportive & Palliative Care. Vol 27, No 34, 2009: pp. 5757-5762. Chao H, Wang L, Hao J, Ni J, Chang L, Graham P, Kearsley J, Li Y. Combination of the histone Deacetylase inhibitor LBH589 with Docetaxel is highly effective in treating human epithelial ovarian cancer. Cancer Letters. 2013; 329:17-26. Hao JL, Ni J, Graham P, Cozzi P, Bucci J, Kearsley J and Li Y. The CD44 isoforms in prostate cancer metastasis and progression. World Journal of Cancer Research 2013; 1:112. Xiao W, Graham P, Hao JL, Chang L, Ni J, Power C, Dong Q, Kearsley J and Li Y. Combination therapy with the histone Deacetylase inhibitor LBH598 and radiotherapy is an effective regimen for prostate cancer cells. PloS ONE. 2013; 8:e74253. Shigdar S, Qian C, Lv L, Pu C, Li Y, Li L, Marappan M, Li J, Wang L, Duan W. The use of sensitive chemical antibodies for diagnosis: detection low levels of EpCAM in breast cancer. PloS ONE. 2013; 8:e57613. Shigdar S, Qian L, Zhou SF, Xiang DX, Wang T, Li Y, Lim LY, Kong LX, Li LH, Duan W. RNA aptamers targeting cancer stem cell marker CD133. Cancer Letters. 2013; 330:84-95. Deng JL, Wang L, Chen HM, Li L, Ma YM, Ni J, Li Y. The role of tumour-associated MUC1 in epithelial ovarian cancer metastasis and progression. Cancer and Metastasis Reviews. 2013; 32:535-551. with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death and Disease. 2013; 4:e875. Krishnan, S. and Maclean J (2013). Practice of laryngectomy rehabilitation interventions: a perspective from Australia. Current Opinion in Otolaryngology and Head and Neck Surgery 21(3):224-229. Other Published Material You J, Cozzi PJ, Fitzgerald A, Walsh B, Russell PJ, Willcox M, Graham P and Li Y. Prostate cancer biomarkers and the emerging proteomic techniques used in biomarker research. Horizons in Cancer Research, edited by Hiroto S. Watanabe. Nova Science Publishers, Inc. USA. 2012;47:136. Perry, A. and Maclean, J. (2012) Rehabilitation after Treatment for Recurrent Head and Neck Cancer. In H. Mehanna and K. Ang (Eds), Head and Neck Cancer Recurrence: Evidence-based, Multidisciplinary Management (pp. 253-259). Germany: Thieme. You J, Willcox M, Madigan MC, Wasinger V, Schiller B, Walsh B, Graham P, Kearsley J and Li Y. Tear as a source of protein biomarkers for human disease diagnosis and prognosis. Advancers in Clinical Chemistry, edited by Greg Makowski, Elsevier. 2013; 62:151-187. Maclean, J – Co-Author - ACI - Care of adult patients in acute care facilities with a tracheostomy – Clinical Practice Guideline 2013. Maclean, J – Co-Author - Speech Pathology Australia Clinical Guideline – Laryngectomy Management 2012. Presentations at Scientific Meetings and Conferences 2012 - International Xiao W, Graham P, Power C, Dong QH, Cozzi PJ, Kearsley J and Li Y (2012). The histone deacetylase inhibitor LBH589 combined with radiation is an effective regimen for prostate cancer. Advances in prostate cancer researchAACR special conference, 6-9 Feb. Orlando USA. Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Shigdar S, Delprado W, Graham P, Bucci J, Kearsley J and Li Y. Epithelial cell adhesion molecule (CD326) is associated with prostate cancer metastasis and chemo-/ radioresistance via PI3K/Akt/mTOR signaling pathway. International Journal of Biochemical Cell Biology. 2013; 45:2736-2748. Wang L, Chen HM, Liu FH, Beretov J, Hao JL, Chao HT, Perkins AC, Kearsley J and Li Y (2012). Studies of the effect of anti-MUC1 monoclonal antibody (C595) with docetaxel in in vitro epithelial ovarian cancer cells and an in vivo animal model. The 3rd International Ovarian Cancer Symposium: Prevention, Detection and Treatment of the Disease and Its recurrence, 10-11 May. Pittsburgh, PA, USA. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y. Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated Li Y, Chao HT, Wang L, Hao JL, Ni J, Graham P, Kearsley J (2012). Combination of low dose histone deacetylase inhibitor, LBH589, with docetaxel is an effective option for 78 epithelial ovarian cancer treatment. The 3rd International Ovarian Cancer Symposium: Prevention, Detection and Treatment of the Disease and Its recurrence, 10-11 May, Pittsburgh, PA, USA. in vitro and in vivo prostate cancer metastasis and chemoresistance. 14th International Biennial Congress of the Metastasis Research Society, 2-5 September, Brisbane, Australia. Beretov J, Wasinger V, Graham P, Kearsley J and Li Y (2012). Identification of novel urine biomarkers from metastatic breast cancer patients using proteomic approaches. Asia Oceania Human Proteome Organization (AOHUPO) 6th Congress, 5-7, Beijing, China. Chang L, Peter G, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2012). Developing radiation resistant prostate cancer cell lines with epithelial mesenchymal transition (EMT) characteristic for prostate cancer treatment. The St George & Sutherland Medical Research Symposium, 11 Oct, 2012, Sydney, Australia. Beretov J, Wasinger V, Graham P, Kearsley J and Li Y (2012). Proteomic identification of novel urine biomarkersfor the early detection of breast cancer. HUPO 11th Annual World Congress, September 9-13, Boston, USA. Maclean, J., Szczesniak, M., Zhang, T., Graham, P., and Cook, I. (2012). Dysphagia is a Prevalent and Under Recognized Complication of Head and Neck Radiotherapy. Paper presented at. Dysphagia Research Society, Toronto, USA, March 2012. Maclean, J., Szczesniak, M., Pramsothy, S., Zhang, T., Graham, P., & Cook, I. (2012). Esophageal Dysmotility in Laryngectomy Patients: An Unrecognized Association?. Paper presented at Dysphagia Research Society, Toronto, USA, March 2012. Kearsley, J. Analysis of student reflections: “It is not a disease we treat but a person”. Paper presented at the Palais des Congrès,19th International Congress on Palliative Care, Montreal, Canada. October. Li, Y., Chao, H., Wang, L., Hao, J., Ni, J., Graham, P. and Kearsley, J. (2012). Combination of low dose histone deacetylase inhibitor, LBH589, with docetaxel is an effective option for epithelial ovarian cancer treatment. Paper presented at the The 3rd International Ovarian Cancer Symposium: Prevention, Detection and Treatment of the Disease and Its recurrence. Pittsburgh, PA, USA, May. 2012 - National Molloy, T., Pajic, M., Holzhauser, S., Graham, P., Millar, E., & Sutherland, R. (2012). Identification of miRNAs as potential mediators of radiotherapy resistance in breast cancer. Paper presented at the 24th Lorne Breast Conference. Victoria. Ni J, Cozzi P, Beretov J, Duan W, Delprado W, Graham P, Kearsley J and Li Y (2012). Over-expression of EpCAM (CD326) and CD44 variants in human prostate cancer cells are potential therapeutic targets for targeted therapy. 13th Australasian Prostate Cancer Conference, 31 July. Melbourne. Li Y, Hao JL, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, Xiao W, Cozzi PJ, Kearsley J (2012). Over-expression of either CD44 or CD147 modulates Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Delprado W, Graham P, Bucci J, Kearsley J and Li Y (2012). EpCAM (CD326) and CD44 variants are biomarkers associated with prostate cancer metastasis and progression. The St George & Sutherland Medical Research Symposium, 11 October, Sydney. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2012). Epithelial mesenchymal transition (EMT) is involved in the prostate cancer radiation resistance. IPOS 14th world congress and COSA’s 39th annual scientific meeting, 13-15 November, Brisbane. Beretov J, Wasinger V, Graham P, Kearsley J and Li Y (2012). Discovering Urine Protein Biomarkers in Breast Cancer using Proteomic Technology. The St George & Sutherland Medical Research Symposium, 11 October, Sydney. Beretov J, Wasinger V, Peter Scwartz, Graham P, Kearsley J and Li Y (2012). Discovering Urine Protein Biomarkers in Breast Cancer using Proteomic Technology. “Proteomics and Beyond” Symposium, Macquarie University, 7th November, Sydney. Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Delprado W, Graham P, Bucci J, Kearsley J and Li Y (2012). EpCAM (CD326) is a biomarkers associated with prostate cancer metastasis and progression. AACBS annual scientific meeting, Sydney, 16 December 2012. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2012). Acquisition of radioresistance and EMT/ CSC phenotypes is linked with activation of the PI3K/Akt/ mTOR pathway in prostate cancer cells. AACBS annual scientific meeting, Sydney, Australia, 16 December 2012. Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Oesophageal dysmotility in laryngectomy patients: An unrecognized association, Brisbane, October, 2012, Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, Long-term dysphagia following Radiotherapy. 79 Maclean, J.C., Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, invited panellist IFHNOS Session 3: Multidisciplinary Therapy. 2013 - International Li Y, Wang L, Chao H, Hao J, Ni J, Chang L, Deng J, Graham P, Kearsley J (2013). Combining low dose LBH589 with docetaxel increases apoptosis in epithelial ovarian cancer cells via PI3K/Akt /mTOR signalling pathway. IGCS, Bali, Indonesia, 11-13 April 2013. Chang L, Wasinger V, Graham P, Hao JL, Ni J, Beretov J, Bucci J, Cozzi P, Kearsley J and Li Y (2013). Identification of novel biomarkers for prostate cancer radioresistance using the label-free LC-MS/MS approach. HUPO 12th Annual World Congress, Yokohama, Japan, 14-18 September 2013. Beretov J, Wasinger V, Schwartz P, Graham P, Millar E, Kearsley J and Li Y (2013). Proteomic investigation of breast cancer biomarkers using human plasma and serum samples. HUPO 12th Annual World Congress, Yokohama, Japan, 14-18 September 2013. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2013). PI3K/Akt/mTOR dual inhibitors have obvious advantages over single inhibitors in overcoming prostate cancer radioresistance. AACR- Molecular Targets and Cancer Therapeutics, Boston, MA, USA, 19-23 Oct 2013. Li Y, Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J (2013). Prostate cancer radioresistance is associated with acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes via activation of the PI3K/Akt/mTOR pathway. The 6th EMT International Association (TEMTIA) Conference-Alicante, Spain, 13-16 Nov 2013. Maclean, J.C., Ward EC., Findlay M, Rees G Dysphagia and nutritional management in Australian and New Zealand head and neck cancer centres , Dysphagia Research Society, Seattle, USA, March. 2013 - National Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Delprado W, Graham P, Bucci J, Kearsley J and Li Y (2013). CD44 variant 6 is a biomarkers associated with prostate cancer metastasis and progression. The Lowy Cancer Symposium. UNSW, Sydney,May. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2013). Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Prostate Cancer World Congress, Melbourne, 6-10 August. 80 Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Melbourne, September, 2013, Cricopharyngeal dysfunction – assessment and treatment. Community Engagement A/Prof Yong Li Associate Editor of World Journal of Cancer Research, USA (2012). Member, Epithelial-Mesenchymal Transition International Association (TEMTIA) 2013. Vice-president of the Australian Chinese Association of Chinese Biomedical Scientists (AACBS) 2013~ and responsible for organizing the Annual meeting and scientific meeting. Dr Julia Maclean Executive member, Australian and New Zealand Head and Neck Cancer Research Foundation Treasurer, Executive Australian and New Zealand Head and Neck Cancer Society. SURGERY PERIOPERATIVE & ANAESTHETIC SERVICES Anaesthesia St George Hospital > 83 Cardiothoracic Surgery > 85 Liver and Peritonectomy Surgery > 90 Orthopaedic Surgery > 96 Trauma > 104 Vascular Surgery > 108 > Department of Anaesthesia St George Hospital Head of Department Richard Morris MBBS FANZCA Senior Medical- Staff Specialists Maggie Bailey BMBS FANZCA Lecturer Conjoint UNSW Chimene Bhar MBBS FRCA Neil Bradburn MBBS FANZCA Lecturer Conjoint UNSW Peter Cox MBBS FANZCA Marie Dreux BMBS FANZCA Lecturer Conjoint UNSW Anthony Lewis PhD MB BCh FRCA FANZCA Liz Mackson MBBS FANZCA Andrew Mcdonald MBBS FANZCA Peter Nay MBBS FRCA FANZCA She-yin Ng MBBS FANZCA Pauline Paton MBBS FANZCA Sharon Tivey MBBS FANZCA Lecturer Conjoint UNSW Anica Vasic MBBS FANZCA Visiting Medical Officers Andrew Armstrong MBBS FANZCA Lecturer Conjoint UNSW Erez Ben-Menachem MBBS FANZCA Philip Black BMBS FANZCA Peter Brennan MBBS FANZCA Colleen Bruce MBBS FANZCA Angela Brothers MBBS FANZCA Matthew Bruce MBBS FANZCA Matthew Chiew MBBS FANZCA Matthew Coady MBBS FANZCA Michael Cooper BMBS FANZCA Daniel Cox BMBS FANZCA Vincent DaSilva MBBS FANZCA Cyrus De Souza MBBS FANZCA Tamara Eichel MBBS FANZCA Robert Fabina MBBS FANZCA Alex Fang MBBS FANZCA Salwan Fransi MBBS FANZCA Lecturer Conjoint UNSW David Goodie MBBS FANZCA Rajiv Gupta MBBS FANZCA Andrew Guy MBBS FANZCA Simon Harper MBBS FANZCA Drew Heffernan MBBS FANZCA Michael Henderson MBBS FANZCA Robert Higgs MBBS FANZCA Mark Higney MB ChB FRCA FANZCA Andrew Howard MBBS FANZCA Cameron Hunt MBBS FANZCA Michael Kerr MBBS FANZCA Andrew Kennedy MBBS FANZCA Gerhard Labuschage MB ChB MMed(Anest) FCA(SA) FANZCA Harold Lam MBBS FANZCA Mike Lambros MBBS FANZCA Ben Ma MBBS FANZCA Bobby Manasiev MBBS FANZCA Joanne Momsen MBBS FANZCA Gisele Mouret MBBS FANZCA Jodi Murphy MBBS FANZCA Manu Narayanaswamy MBBS FANZCA Neeraj Pal MBBS FANZCA Pamela Salerno MBBS FANZCA Marianne Sidhom MBBS FANZCA Kate Smyth MBBS FANZCA Vincent Sperando MBBS FANZCA Mark Steward MBBS FANZCA Abhijeet Tandel MBBS FANZCA Sue-Ann Wan MBBS FANZCA Helen Zois MBBS FANZCA Research Projects in Progress Enhanced oral intake prior to colonoscopy, G Labuschagne, M Kerr, T Holliday, R Morris. Comparison of Prothrombinex vs Fresh Frozen Plasma during Peritonectomy Surgery A Lewis, S Ho, D Morris, W Liau Original Peer-Reviewed Publications Howe PW, Cooper MG. Blood loss and replacement for spring cranioplasty in Australia – a prospective national audit. Anaesthesia and Intensive Care 2012; 40: 107-113. Santoro AS, Cooper MG, Cheng A. Failed intubation and failed oxygenation in a child. Anaesthesia & Intensive Care 2012:40: 1056-1058. Liao AY, Levin B, Daniel M, Chan L, Cooper MG, Birman CS. Emergency EXIT: an urgent ex utero intrapartum trachestomy for giant fetal neck mass. Aust NZ J Surgery 2013; 83: 684-685. Chatterjee DJ, Reid C, Lewis A. A potential technique for flexible scope-assisted intubation using an Ambu aScope 2TM inserted via a supraglottic airway device. Anaesthia and Intensive Care. 2012 July 40(4):724. 83 Reid C, Lewis A, Habig K, Burns B, Billson F, Kunkel S, Fisk W. Sustained life-like waveform capnography after human cadaveric tracheal intubation. Emergency Med J. 2013 Oct 8. doi: 10.1136/emermed-2013-203105. [Epub ahead of print]. Presentations at Scientific Meetings and Conferences 2012 - International Cooper MG. Pulse oximetry – Lifebox and a standard of care for anaesthesia and surgery in Papua New Guinea. Papua New Guinea Medical Symposium, Port Moresby, September 2012. 2013 - International Lewis, A, Airway Management in Prehospital and Retrieval Medicine. Society of Anaesthetists of Wales Autumn Meeting. LLandrindod Wells, Wales, 7th November 2013 Lewis, A Simulation using Mobile Technology. Society of Anaesthetists of Wales Autumn Meeting. LLandrindod Wells, Wales, 7th November 2013 Lewis A, Richmond C. Sim Training. Cost effective ways to Train in your department. Developing Emergency Medicine, Havana, Cuba. 17th September 2013. Lewis A, Richmond C. Train the Trainer Sim Training. Developing Emergency Medicine, Havana, Cuba. 17th September 2013. 2013 - National ANZAC, Gallipoli, WW1. 8th International Symposium on the History of Anaesthesia, Sydney, Jan 2013. Graves M, Cooper MG. Anaesthesia at a Casualty Clearing Station: Review of an Australian Anaesthetists role in the Great War. 8th International Symposium on the History of Anaesthesia, Sydney, Jan 2013. Cooper MG (speaker and chair). The challenges of paediatric anaesthesia in the developing world. Society of Paediatric Anaesthetists of Australia & New Zealand Annual Meeting, October 2013, Sydney. 84 Cooper MG. Technology vs Tradition: How to get into print. NSW Anaesthetic Continuing Education meeting, Australian & New Zealand College of Anaesthetists, Sydney, Jun 15, 2013. Howard, A. Peri-operative Arrhythmias at Technology Meets Tradition, ANZCA and ASA 79th Continuing Education Seminar, Sydney, 15th June 2013. > Department of Cardiothoracic Surgery Head of Department Dr Gary Fermanis MBBS (Hons) FRACS Visiting Medical Officers Dr Con Manganas MBBS MS (NSW) FRACS Dr Matthew Horton MBBS FRACS Dr Sheen Peeceeyen MCh Senior Research Dr Christopher Cao MBBS, BSc (Med) Nursing Research Patricia Newbon, RN Research Projects in Progress Review of patients who have undergone pneumonectomy at St George Hospital 1992 - 2014, with a view to long term outcomes. Dr A Kashani (Thesis). Original Peer-Reviewed Publications Cao C, Tian D, Manganas C, Matthews P, Yan TD. Systematic review of trimodality therapy for patients with malignant pleural mesothelioma. Ann Cardiothorac Surg. 2012 Nov;1(4):428-37. Cao C, Indraratna SAP, Manganas C, Bannon P, Black D, Yan T. D. Systematic Review and Meta-analysis of Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement for Patients with Severe Aortic Stenosis. Ann Cardiothorac Surg. 2012 Nov 15. DOI: 10.3978/j.issn.2225-319X.2012.11.09 Cao C, Manganas C, Ang SC, Peeceeyen S, Yan TD. Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of propensity score-matched patients. Interact Cardiovasc Thorac Surg. 2013 Mar 16(3) 244-9. Cao C, Manganas C, Indraratna P, Ang S, Bannon P, Yan T. Cost-effectiveness of TAVI versus surgery for high-risk patients with aortic stenosis. J Am Coll Cardiol. 2013 Apr 23;61(16):1747-8. controlled trials. J Thorac Cardiovasc Surg. 2013 Aug 146(2) 255-61. Cao C, Manganas C, Ang S, Yan, TD. A systematic review and meta-analysis on pulmonary resections by robotic video-assisted thoracic surgery. Annals of Cardiothoracic Surgery. 2012 May. 1 (1): 3-10. Cao C, Manganas C, Ang S, Yan, TD. A meta-analysis of unmatched and matched patients comparing videoassisted thoracoscopic lobectomy and conventional open lobectomy. Annals of Cardiothoracic Surgery. 2012 May. 1 (1): 16-23. Cao C, Manganas C, Bannon P, Vallely M, Yan TD. Drugeluting stents versus coronary artery bypass graft surgery in left main coronary artery disease: A meta-analysis of early outcomes from randomized and nonrandomized studies. J Thorac Cardiovasc Surg. 2013 Mar 145(3) 73847. Farkouh ME, Domanski M, Sleeper LA, Siami FS, Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky A, Boineau R, Weinberger J, Ramanathan K, Sousa JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, Muratov V, Bansilal S, King S 3rd, Bertrand M, Fuster V; FREEDOM Trial Investigators. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. 2012 Dec 20;367(25):2375-84. Other Published Material Cao C, Manganas C, Byrom M, Yan, T.D. Re: Radial artery or saphenous vein, a graft of second choice in coronary artery bypass surgery. J Thorac Cardiovasc Surg Apr;145(4):1147-8. Cao C, Manganas C, Indraratna P, Ang S, Yan T. Re: Transcatheter aortic valve implantation (TAVI): risky and costly. BMJ 2012;345 e4710. Cao C, Manganas C, Byrom M, Yan TD. Reply to the editor. J Thorac Cardiovasc Surg. 2013 Apr;145(4):1147-8. Cao C, Manganas C, Horton M, Bannon P, MunkholmLarsen S, Ang SC, Yan TD. Angiographic outcomes of radial artery versus saphenous vein in coronary artery bypass graft surgery: A meta-analysis of randomized 85 Presentations at Scientific Meetings and Conferences All presentations are by Dr Christopher Cao. The 7th China Lung Cancer Minimally Invasive Therapy Forum/The 4th Asia-Pacific minimally Invasive Thoracic Surgery Conference (Guangzhou, China; December 2013) 1. XSOLA Study 2. Meta-analysis of Segmentectomy vs Lobectomy for Patients with NSCLC Meta-analysis of Propensity Score Matched Patients 7. Level 1A Evidence on Angiographic Outcomes of Radial Artery versus Saphenous Vein in Coronary Artery Bypass Graft Surgery 8. A Systematic Review and Meta-analysis on Pulmonary Resections by Robotic Video-assisted Thoracic Surgery 9. Cross-sectional Study on Lobectomy Approach (X-SOLA) 15th World Conference on Lung Cancer (Sydney, Australia; October 2013) 10. Should Clopidogrel be Discontinued Prior to Coronary Artery Bypass Graft Surgery for Patients with Acute Coronary Syndrome? 1. Systematic Review of Pleurectomy in the Treatment of Malignant Pleural Mesothelioma 11. Systematic Review of Trimodality Therapy for Patients with Malignant Pleural Mesothelioma 2. A Meta-analysis of Extended Pleurectomy/ Decortication versus Extrapleural Pneumonectomy in the Treatment of Malignant Pleural Mesothelioma EuroPCRMeeting (Paris, France; May 2013): 3. Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer - A metaanalysis of propensity score matched patients 4. A Systematic Review and Meta-analysis on Pulmonary Resections by Robotic Video-assisted Thoracic Surgery 5. Cross-sectional Study on Lobectomy Approach (X-SOLA) 6. Video-assisted Thoracoscopic Surgery at 20 Years: A Consensus Statement Cardiac Society of Australia and New Zealand Annual Scientific Meeting (Darwin, Australia; August 2013): 1. A Systematic Review and Meta-analysis of Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement for Patients with Severe Aortic Stenosis (Baxter Young Achiever Award Winner) 2. A Systematic Review of the Cost-effectiveness of Transcatheter Aortic Valve Implantation 3. A Meta-analysis of Drug-eluting Stents versus Coronary Artery Bypass Graft Surgery in Left Main Coronary Artery Disease 4. Systematic Review of Pleurectomy in the Treatment of Malignant Pleural Mesothelioma 5. Video-assisted Thoracoscopic Surgery at 20 Years: A Consensus Statement 6. Video-assisted Thoracic Surgery versus Open Thoracotomy for Non-small Cell Lung Cancer – A 86 1. TAVI versus Surgical Aortic Valve Replacement for Patients with Severe Aortic Stenosis 2. Cost Analysis of TAVI – Can We Afford It? 20th Anniversary of VATS Lobectomy Consensus Meeting (Edinburgh, UK; November 2012): 1. VATS Lobectomy versus Open thoracotomy – A Systematic Review and Meta-analysis Propensity Score Matched Patients 2. Cross-sectional Study on Lobectomy Approach (X-SOLA) Cardiac Society of Australia and New Zealand Annual Scientific Meeting (Brisbane, Australia; August 2012): 1. Drug-Eluting Stents versus Coronary Artery Bypass Graft Surgery in Left Main Coronary Artery Disease - A Meta-analysis of Randomized and Nonrandomized Studies 2. Current Level IA Evidence for Radial Artery versus Saphenous Vein in Coronary Artery Graft Surgery – A Systematic Review and Meta-analysis of Randomized Controlled Trials Royal Australasian College of Surgeons ASC (Kuala Lumpur, Malaysia; May 2012): 1. Drug-Eluting Stents versus Coronary Artery Bypass Graft Surgery in Left Main Coronary Artery Disease - A Meta-analysis of Randomized and Nonrandomized Studies 2. Current Level IA Evidence for Radial Artery versus Saphenous Vein in Coronary Artery Graft Surgery – A Systematic Review and Meta-analysis of Randomized Controlled Trials 3. Meta-analysis of VATS versus Open Thoracotomy for Early-Stage NSCLC 4. An Unusual Presentation of Recurrent Pneumonia (e-Poster). 87 > Department of Colorectal Surgery Head of Department Assoc Professor David Lubowski FRACS Senior Medical Professor Denis King OAM FRACS Dr D Shevy Perera FRACS Dr Steven Gan FRACS Dr Daniel Kozman FRACS Junior Medical Dr Kim Phan-Thien FRACS Colorectal Fellow Research Staff Vicki Patton RN Bsc(Health) MN(Hons) Original Peer-Reviewed Publications 2012 Lubowski DZ. Editorial. Colorectal surgery: rigour and logic when treating pelvic floor disorders. Editorial; ANZJS 2012; 82:383-384 . Dinning PG, Hunt LM, Arkwright JW, Patton V, Szczesniak MM, Wiklendt L,Davidson JB, Lubowski DZ, Cook IJ. Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slowtransit constipation. British J Surg 2012; 99(7):1002-1110. 2013 Wang S, McKay GD, Vonthethoff L, Lubowski DZ. Latent schistosomiasis triggering mesenteric panniculitis. ANZJS 2013; 83:396-397. Lubowski DZ. Editorial. Multidisciplinary team meetings. ANZJ Surg 2013; 83:99-100. Patton V, Wiklendt L, Arkwright JW, Lubowski DZ, Dinning PG.The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence. Br J Surg 2013; 100(7); 959-968 Mar 27. Diezmos EF, Sandow SL, Marcus L, Perera DS, Lubowski DZ, King DW, Bertrand PP, Liu L Expression and localization of pannexin-1 hemichannels in human colon in health and disease. Neurogastroenterol Motil 2013; 25, e395–e405. 88 Dinning P, Wiklendt L, Gibbins I, Patton V, Bampton P, Lubowski DZ, Cook IJ, Arkwright J. Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fibre-optic high-resolution manometry studies. Neurogastroenterol Motil 2013; 25(10): e64. Wang DH, Blenman N, Maunder S, Patton V, Arkwright J. An optical fiber Bragg grating force sensor for monitoring sub-bandage pressure during compression therapy. Optics Express. 2013 Aug 26; 21(17):19799-807. Presentations at Scientific Meetings and Conferences 2012 - International Sacral nerve stimulation workshop. Satellite Medtronic meeting at ASCRS meeting, San Antonio, USA, 2-3 June 2012. “Sacral nerve stimulation: Clinical results” David Z. Lubowski. International College of Surgeons, 38th Biennial World Congress, Brisbane, Australia, 7-9 November 2012. “Sacral Nerve Stimulation for Faecal Incontinence” David Z. Lubowski. International Society University Colorectal Surgeons ISUCRS Biennial Congress XXV Bolongna Italy 24 June 2012. “Clinical characteristics of patients treated with sacral nerve stimulation for neurogenic faecal incontinence.” V Patton. 2013 - International American Society of Colon and Rectal Surgeons ASCRS meeting, Phoenix, 1 May 2013. Panel Symposium on “Worst Cases”. “Cases on: Anal fistula” David Z. Lubowski New Zealand Medical Association, GP CME Meeting, Rotorua, 20 June 2013. “Management of anorectal conditions” David Z. Lubowski. Combined Spring Meeting of Colorectal Surgical Society of Australia and NZ with Colon and Rectal Section of RACS, Gold Coast 11-13 July 2013. “Management of constipation / internal rectal prolapse.” David Z. Lubowski 2012 - National UNSW Women’s Health and Research Institute of Australia, Sydney 4 Feb 2012. “Proctalgia and Proctalgia Fugax” David Z. Lubowski. AGW , Adelaide, 18 October 2012. “Sacral nerve stimulation for colonic motility disorders – is it prime time?” David Z. Lubowski. 2013 - National Annual Scientific Meeting Urogynaecological Society of Australasia, Sydney, 16 March 2013. “Management of post-defaecation soiling” David Z. Lubowski. Pharmaceutical Society of Australia, Annual Meeting, Sydney 2 June 2013. “Modern management of anorectal conditions” David Z. Lubowski. 89 > Department of Liver and Peritonectomy Surgery Head of Department Research Projects in Progress Professor David Lawson Morris Pre-clinical evaluation of a novel nanoparticle, albuminbound albendazole in the treatment of chemo-resistant ovarian cancer. Principal investigators: Mohammad Pourgholami, Martina Stenzel, Lubna Noorani, Samina Badar, David Morris. Senior Medical Dr Jai Seema Bagia Junior Medical Dr Nayef Alzahrani (Fellow – KSA Training Program) Dr Saleh Alzahrani (Fellow – KSA Training Program) Research Staff Dr Mohammad Pourgholami, Principal Scientific Officer MSc Pharmaceutical Sciences and PhD Pharmacology Dr Jing Zhao, Hospital Scientist, M Med Sc Dr Javed Akhter, Technical Officer, MSc, PhD Dr Anahid Ehteda, Postdoc Research Fellow, UNSW BSc (Microbiology); MSc (Microbiology), PhD Dr Krishna Pillai, Research Assistant M Med Sc (Pharmaceutical Drug Development), Ms Stephanie Wai Ling Chu, Research Assistant, BSc (Hon); MSc Mrs Samina Badar, Research Assistant MSc Mrs Farnaz Bahrami-Budlalu, Postgraduate Research Student, Pharm D (Doctorate degree in Pharmacy), Mrs Lubna Noorani, PhD student, UNSW M.Pharm. Dr Afshin Amini, PhD student, MD Dr Samar Masoumi Moghaddam, PhD student, MD Dr Parvin Ataie-Kachoie, Research Officer, PharmAust Ltd Pharm D (Doctorate degree in Pharmacy), PhD. Research Grants ARC project grant. Stenzel M, Morris DL, Pourgholami MH Targeted therapies using Sprouty proteins: Synthetic strategies to polyion complex micelles as smart nano-sized drug carriers for proteins (390,000.00 over 3 years 20142017). ARC project grant Stenzel M, Morris DL, Pourgholami MH A platform for the efficient optimization of drug delivery using cross-linked micelles and thioclick-chemistry toward better anti-cancer treatment. ($450,000.00 over 3 years 2011-13). 90 Determination of the anticancer activity of monepantel (AAD1566) in preclinical models of cancer. Principal investigators: David Morris, Stephanie Chu, Samina Badar, Parvin Ataie-Kachoie, Mohammad Pourgholami. Evaluation of minocycline as a potential drug for the treatment of cancer-induced angiogenesis, metastasis and malignant ascites formation. Principal investigators: Mohammad Pourgholami, Stephanie Chu, Samina Badar, Parvin Ataie, David Morris. Role of human Sprouty proteins ovarian and breast cancers Principal investigators: Mohammad Pourgholami, Ahmed Mekkawy, Samina Badar, Martina Stenzel, David Morris. Development of mucolytic comprising of bromelain and N-acetyl cysteine for the dissolution of mucin secreted by pseudomyxoma peritonei, with enhanced efficacy by addition of other agents. Principal investigators: J.Akhter, K.Pillai, A Ekheda and DL. Morris. Physio-chemical analysis of three grades of mucin secreted by pseudomyxoma peritonei. Principal investigators: K.Pillai, J.Akhter and DL. Morris. Optimization of a mixture of bromelain and N-acetyl cysteine for the treatment of malignant peritoneal mesothelioma. Principal investigators: K.Pillai, J.Akhter and DL. Morris. Combination of bromelain, N-acetyl cysteine and aspirin for the treatment of malignant peritoneal mesothelioma. Principal investigators: K.Pillai, J.Akhter and DL. Morris. Anti-Tumour and Chemosensitising effect of a combination of bromelain + N-acetylcystein with cytotoxic drugs on cancer cells. Principal investigators: L. Pillai, J.Akhter and DL Morris. Comparison of three thermal tumour ablative devices such as monopolar, bipolar radiofrequency and microwave for their efficacy in the absence and in the presence of heat sink in perfused calf liver. Principal investigators: K.Pillai, J.Akhter and DL. Morris. Tumour cell release dynamics during thermal ablation of liver tumours that involve the piercing of the surface of tumours. Principal investigators: K.Pillai, J.Akhter and DL. Morris. Pharmacokinetics of Monepantel in Mice. Principal investigators: A Ehteda, DL. Morris. Combination therapy of Monepantel (AAD1566) with commonly used chemotherapeutic agents. Principal investigators: DL. Morris, MH Pourgholami, Parvin AtaieKachoie. Cytotoxic and mucolytic effects of bromelain in combination with N-acetylcysteine with potential value in pseudomyxoma peritonei. Principal investigators: DL. Morris, A Amini. Evaluation of the expression of human Sprouty proteins in epithelial ovarian cancer. Principal investigators: DL. Morris, S Masoumi Moghaddam. Original Peer-Reviewed Publications 2012 Amini, A., Masoumi moghaddam, S., Morris, D. L., & Pourgholami, M. H. (2012). The Critical Role of Vascular Endothelial GrowtFactor in Tumor Angiogenesis. Current Cancer Drug Targets, 12(1), 23-43. Carcinomatosis: Cytoreductive Surgery and HIPEC–Overview and Basics. Cancer Investigation, 30(3), 209-224. Cao, C. Q., Yan, T. D., Deraco, M., Elias, D., Glehen, O., Levine, Sugarbaker, P. H. (2012). Importance of gender in diffuse malignant peritoneal mesothelioma. Annals of Oncology, 23 (6), 1494-1498. Cao, C. Q., Yan, T. D., Morris, D. L., Van der speeten, K., Laurberg, S., Glehen, O., Sugarbaker, P. H. (2012). Prospective Registry On Mesothelioma Peritonei Treatment (PROMPT): study design and rationale.]. Tumori, 98(1), 166-171. Chua, T. C., & Morris, D. L. (2012). Colorectal Liver Metastases with Extrahepatic Disease-A New Criteria for Oncologic Resection? Journal of gastrointestinal cancer, 43(3), 502-504. Chua, T. C., & Morris, D. L. (2012). Exploring the role of resection of extrahepatic metastases from hepatocellular carcinoma. Surgical Oncology, 21(2), 95-101. Chua, T. C., & Morris, D. L. (2012). Resectable Colorectal Liver Metastases: Optimal Sequencing of Chemotherapy. Journal of gastrointestinal cancer, 43(3), 496-498. Chua, T. C., & Morris, D. L. (2012). Therapeutic potential of surgery for metastatic colorectal cancer. Scandinavian Journal of Gastroenterology, 47(3), 258-268. Amini, A., Masoumi moghaddam, S., Morris, D. L., & Pourgholami, M. H. (2012). Utility of vascular endothelial growth factor inhibitors in the treatment of ovarian cancer: from concept to application. Journal of Oncology, Volume 2012 (Article ID: 540791), 1-14. doi: 10.1155/2012/540791. Chua, T. C., Al-Alem, I., Zhao, J., Glenn, D. W., Liauw, W., & Morris, D. L. (2012). Radiofrequency ablation of concomitant and recurrent pulmonary metastases after surgery for colorectal liver metastases. Annals of Surgical Oncology, 19(1), 75-81. Bahrami, F., Morris, D. L., & Pourgholami, M. H. (2012). Tetracyclines: drugs with huge therapeutic potential. MiniReviews in Medicinal Chemistry, 12(1), 44-52. Chua, T. C., Chong, C. H., & Morris, D. L. (2012). Peritoneal Mesothelioma. Current Status and Future Directions. [10.1016/j.soc.2012.07.010]. Surgical Oncology Clinics of North America, 21(4), 635-643. Bester, L., Meteling, B., Pocock, N. A., Pavlakis, N., Chua, T. C., Saxena, A., & Morris, D. L. (2012). Radioembolization versus Standard Care of Hepatic Metastases: Comparative Retrospective Cohort Study of Survival Outcomes and Adverse Events in Salvage Patients. Journal of Vascular and Interventional Radiology, 23(1), 96-105. Brucher, B. L., Piso, P., Verwaal, V., Esquivel, J., Derraco, M., Yonemura, Y, Nissan, A. (2012). Peritoneal Chua, T. C., Chong, C. H., Liauw, W. S., & Morris, D. L. (2012). Approach to Rectal Cancer Surgery. International Journal of Surgical Oncology, 2012 (Article ID: 247107), 1-9. Chua, T. C., Chong, C. H., Liauw, W. S., Zhao, J., & Morris, D. L. (2012). Inflammatory Markers in Blood and Serum Tumor Markers Predict Survival in Patients With Epithelial Appendiceal Neoplasms Undergoing Surgical 91 Cytoreduction and Intraperitoneal Chemotherapy. Annals of Surgery, 256(2), 342-349. efficacy in nude mice. Anticancer Research, 32(9), 36593666. Chua, T. C., Esquivel, J., Pelz, J. O., & Morris, D. L. (2012). Summary of current therapeutic options for peritoneal metastases from colorectal cancer. Journal of Surgical Oncology, 107(6), 566-573. Khan, A. B., Al-Suhaibani, Y., Al-Mohaimeed, K., & Morris, D. L. (2012). Application of Advanced Multimodality Care to Pseudomyxoma Peritonei Patient: Report of First Patient Treated at a Tertiary Center. Indian Journal of Surgical Oncology, 1(3), 270-273. Chua, T. C., Liauw, W. S., Chu, F., & Morris, D. L. (2012). Summary outcomes of two-stage resection for advanced colorectal liver metastases. [10.1002/jso.23170]. Journal of Surgical Oncology, 107(2), 211-216. Chua, T. C., Liauw, W. S., Chu, F., & Morris, D. L. (2012). Viewing metastatic colorectal cancer as a curable chronic disease. American Journal of Clinical Oncology - Cancer Clinical Trials, 35(1), 77-80. Chua, T. C., Liauw, W. S., Zhao, J., & Morris, D. L. (2012). Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal peritoneal carcinomatosis. International Journal of Clinical Oncology. June 18(3) 439-46. Chua, T. C., Liauw, W., & Morris, D. L. (2012). Early recurrence of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and perioperative intraperitoneal chemotherapy is indicative of a poor survival outcome. International Journal of Colorectal Disease, 27(3), 381-389. Chua, T. C., Moran, B. J., Sugarbaker, P. H., Levine, E., Glehen, O., Gilly, F. N., Morris, D. L. (2012). Earlyand Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Journal of Clinical Oncology, 30(20), 2449-2456. Chua, T. C., Pelz, J. O., & Morris, D. L. (2012). Surgery for colorectal peritoneal carcinomatosis. Scandinavian Journal of Gastroenterology, 47(3), 277-285. Chua, T. C., Saxena, A., Chu, F., & Morris, D. L. (2012). Hepatic Resection for Transplantable Hepatocellular Carcinoma for Patients Within Milan and UCSF Criteria. American Journal of Clinical Oncology - Cancer Clinical Trials, 35(2), 141-145. Chua, T. C., Saxena, A., Liauw, W. S., Chu, F., & Morris, D. L. (2012). Hepatectomy and resection of concomitant extrahepatic disease for colorectal liver metastases - A systematic review. European Journal of Cancer, 48(12), 1757-1765. Ehteda, A., Galettis, P. T., Chu, S. L. W., Pillai, K. R., & Morris, D. L. (2012). Complexation of albendazole with hydroxypropyl-& #226;-cyclodextrin significantly improves its pharmacokinetic profile, cell cytotoxicity and antitumor 92 Kim, Y., Liemmawal, E., Pourgholami, M. H., Morris, D. L., & Stenzel, M. H. (2012). Comparison of shell-crosslinked micelles with soft and glassy cores as a drug delivery vehicle for albendazole: Is there a difference in performance? Macromolecules, 45(13), 5451-5462. Kim, Y., Pourgholami, M. H., Morris, D. L., & Stenzel, M. H. (2012). Effect of cross-linking on the performance of micelles as drug delivery carriers: a cell uptake study. Biomacromolecules, 13(3), 814-825. Klaver, Y., Chua, T. C., De hingh, I., & Morris, D. L. (2012). Outcomes of elderly patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal cancer peritoneal carcinomatosis. Journal of Surgical Oncology, 105(2), 113-118. Masoumi moghaddam, S., Amini, A., Morris, D. L., & Pourgholami, M. H. (2012). Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer. Cancer and Metastasis Reviews, 31(1-2), 143-162. Mekkawy, A. H., Morris, D. L., & Pourgholami, M. H. (2012). HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor. Journal of Oncology, 2012 (Article ID: 950749), 1-9. Mirarabshahii, P., Pillai, K., Chua, T. C., Pourgholami, M. H., & Morris, D. L. (2012). Diffuse malignant peritoneal mesothelioma - An update on treatment. Cancer Treatment Reviews, 38(6), 605-612. Ng, K. M., Chua, T. C., Saxena, A., Zhao, J., Chu, F., & Morris, D. L. (2012). Two decades of experience with hepatic cryotherapy for advanced colorectal metastases. Annals of Surgical Oncology, 19(4), 1276-1283. Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2012). Mucolysis by Ascorbic Acid and Hydrogen Peroxide on Compact Mucin Secreted in Pseudomyxoma Peritonei. [Journal of Surgical Research, 174(2), e69-e73. Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2012). Potential mucolytic agents for mucinous ascites from pseudomyxoma peritonei. Investigational New Drugs, 30(5), 2080-2086. Pourgholami, M. H., Mekkawy, A. H., Badar, S., & Morris, D. L. (2012). Minocycline inhibits growth of epithelial ovarian cancer. Gynecologic Oncology, 125(2), 433-440. Journal of Clinical Oncology - Cancer Clinical Trials. February, doi: 10.1097/COC.0b013e31827deea1. Saxena, A., Chua, T. C., Chu, F., Al-Zahrani, A., & Morris, D. L. (2012). Optimizing the surgical effort in patients with advanced American Journal of Clinical Oncology - Cancer Clinical Trials. Oct 35(5) 439-45. Bester, L., Meteling, B., Pocock, N. A., Saxena, A., Chua, T. C., & Morris, D. L. (2013). Radioembolisation with Yttrium-90 microspheres: An effective treatment modality for unresectable liver metastases. Journal of Medical Imaging and Radiation Oncology, 57(1), 72-80. Saxena, A., Chua, T. C., Perera, M., Chu, F., & Morris, D. L. (2012). Surgical resection of hepatic metastases from neuroendocrine neoplasms: A systematic review. Surgical Oncology, 21(3), e131-e141. Chan, D. L., Morris, D. L., & Chua, T. C. (2013). Clinical efficacy and predictors of outcomes of repeat hepatectomy for recurrent hepatocellular carcinoma – A systematic review. Surgical Oncology, 22(2), e23-e30. Saxena, A., Chua, T. C., Zhao, J., & Morris, D. L. (2012). Liver-directed therapy for neuroendocrine neoplasm hepatic metastasis prolongs survival following progression after initial surgery. Journal of Surgical Oncology, 105(4), 342-350. Chan, D. L., Morris, D. L., Chua, T. C., & Rao, A. (2013). Intraperitoneal chemotherapy in ovarian cancer: A review of tolerance and efficacy. Cancer Management and Research, 4(1), 413-422. Yang, T. X., Chua, T. C., & Morris, D. L. (2012). Radioembolization and chemoembolization for unresectable neuroendocrine liver metastases - A systematic review. Surgical Oncology, 21(4), 299-308. 2013 Al-Alem, I., Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2013). Heat Sink Phenomenon of Bipolar and Monopolar Radiofrequency Ablation Observed Using Polypropylene Tubes for Vessel Simulation. SurgicalInnovation. Oct 16 21(3) 269-76. Amini, A., Ehteda, A., Masoumi, S., Moghaddam, S. M., Akhter, J., Pillai, K., & Morris, D. L. (2013). Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). OncoTargets and Therapy, 6, 403-409. Ataie-Kachoie, P., Badar, S., Morris, D. L., & Pourgholami, M. H. (2013). Minocycline Targets the NF- B Nexus through Suppression of TGF- 1-TAK1-I B Signaling in Ovarian Cancer. Molecular Cancer Research, 11(10), 1279-1291. Ataie-kachoie, P., Morris, D. L., & Pourgholami, M. H. (2013). Minocycline Suppresses Interleukine-6, Its Receptor System and Signaling Pathways and Impairs Migration, Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies. PLoS ONE, 8(4), Article number 60817. Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. (2013). Inhibition of the IL-6 signaling pathway: A strategy to combat chronic inflammatory diseases and cancer. Cytokine & Growth Factor Reviews, 24(2), 163-173. Bester, L., Feitelson, S., Milner, B., Chua, T. C., & Morris, D. L. (2013). Impact of prior hepatectomy on the safety and efficacy of radioembolization with Yttrium-90 microspheres for patients with unresectable liver tumors. American Chua, T. C., Quinn, L. E., Zhao, J., & Morris, D. L. (2013). Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal metastases. Journal of Surgical Oncology, 108(2), 81-88. Ehteda, A., Galettis, P., Pillai, K., & Morris, D. L. (2013). Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumorbearing nude mice. BMC Cancer, 13, Article number 86. Kim, Y., Pourgholami, M. H., Morris, D. L., Lu, H., & Stenzel, M. H. (2013). Effect of shell-crosslinking of micelles on endocytosis and exocytosis: acceleration of exocytosis by crosslinking. Biomaterials Science, 1, 265275. Klaver, Y. L., Chua, T. C., Verwaal, V., De hingh, I. H., & Morris, D. L. (2013). Secondary cytoreductive surgery and peri-operative intraperitoneal chemotherapy for peritoneal recurrence of colorectal and appendiceal peritoneal carcinomatosis following prior primary cytoreduction. Journal of Surgical Oncology, 107(6), 585-590. Koh, J. L., Liauw, W., Chua, T., & Morris, D. L. (2013). Carbohydrate antigen 19-9 (CA 19-9) is an independent prognostic indicator in pseudomyxoma peritonei post cytoreductive surgery and perioperative intraperitoneal chemotherapy. J Gastrointest Oncol, 4(2), 173-181. Moghaddam, S. M., Amini, A., Wei, A. Q., Pourgholami, M. H., & Morris, D. L. (2013). Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines. Journal of Oncology, 2012, Article ID 373826. Morris, D. L. (2013). Peritonectomy HIPEC - Contemporary results, indications. Chinese Journal of Cancer Research, 25(4), 373-374. Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2013). Anticancer Property of Bromelain With Therapeutic 93 Potential in Malignant Peritoneal Mesothelioma. Cancer Investigation, 31(4), 241-250. Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. (2013). MUC1 as a Potential Target in Anticancer Therapies. American Journal of Clinical Oncology, 1-1. doi: 10.1097/COC.0b013e31828f5a07. Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. (2013). Ki67-BCL2 index in prognosis of malignant peritoneal mesothelioma. American Journal of Cancer Research, 3(4), 411-423. Williams, B. H. M., Alzahrani, N. A., Chan, D. L., Chua, T. C., & Morris, D. L. (2013). Repeat cytoreductive surgery (CRS) for recurrent colorectal peritoneal metastases: Yes or no? European Journal of Surgical Oncology (EJSO). doi: 10.1016/j.ejso.2013.10.022. Yang, T. X., Billah, B., Morris, D. L., & Chua, T. C. (2013). Palliative resection of the primary tumour in patients with Stage IV colorectal cancer: systematic review and metaanalysis of the early outcome after laparoscopic and open colectomy. Colorectal Disease, 15(8), e407-e419. Yang, T. X., Morris, D. L., & Chua, T. C. S. (2013). Pelvic exenteration for rectal cancer: A systematic review. Diseases of the Colon and Rectum, 56(4), 519-531. Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. (2013). Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma? American Journal of Cancer Research, 3(3), 312-322. Other Published Material Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. (2013). Oestrogen receptors are prognostic factors in malignant peritoneal mesothelioma. Journal of Cancer Research and Clinical Oncology, 139(6), 987-994. Morris, DL (2013), Cytoreductive Surgery & Perioperative Chemotherapy for Peritoneal Surface Malignancy. Textbook and Video Atlas. PSOGI Group International. Contributing Author. Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. (2013). MUC1 has prognostic significance in malignant peritoneal mesothelioma. The International Journal of Biological Markers, 28(3), 303-312. Presentations at Scientific Meetings and Conferences Pourgholami, M. H., Ataie-Kachoie, P., Badar, S., & Morris, D. L. (2013). Minocycline inhibits malignant ascites of ovarian cancer through targeting multiple signaling pathways. Gynecologic Oncology, 129(1), 113-119. Akhter J, Pillai K, Al-Alem I, & Morris D L (2012). Comparative study of radiofrequency ablation (RFA) of a novel bipolar probe with a unipolar probe (in the presence and absence of vessel simulation), using egg white and ex-vivo liver model. Paper presented at The Royal Australasian College of Surgeons Annual Scientific Congress, Kuala Lumpur, Malaysia. Saxena, A., Chua, T. C., Fransi, S., Liauw, W., & Morris, D. L. (2013). Effectiveness of early and aggressive administration of fresh frozen plasma to reduce massive blood transfusion during cytoreductive surgery. J Gastrointest Oncol, 4(1), 30-39. Saxena, A., & Morris, D. L. (2013). Mortality and Morbidity after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis. Viszeralmedizin, 29(4), 6-6. Ung, L., Chua, T. C., & Morris, D. L. (2013). Cure for peritoneal metastases? An evidence-based review.. ANZ Journal of Surgery, 83(11), 821-826. Ung, L., Chua, T. C., & Morris, D. L. (2013). Peritoneal metastases of lower gastrointestinal tract origin: a comparative study of patient outcomes following cytoreduction and intraperitoneal chemotherapy. Journal of Cancer Research and Clinical Oncology, 139(11), 18991908. Ung, L., Chua, T. C., & Morris, D. L. (2013). Cure for peritoneal metastases? An evidence-based review. ANZ Journal of Surgery, 83(11), 821-826. 2012 - International Pillai K, Pourgholami MH, Akhter J, Chua TC, Morris DL (2012). Ki67 is an important prognostic factor in malignant peritoneal mesothelioma. Poster presented at the Peritoneal Cancer Symposium, Munich, Germany. 2012 - National Ataie-Kachoie P, Badar, S., Morris DL., Pourgholami MH: Minocycline abolishes malignant ascites formation and tumor growth through attenuation of tumor growth factor-ß, vascular endothelial growth factor and interleukin-6 pathways in an experimental model of ovarian cancer. St. George and Sutherland Medical Research Symposium, Sydney, October 2012. Bahrami F, Pourgholami MH, Morris DL: Monepantel suppress ovarian cancer cell proliferation by arresting G0-G1 cell cycle and down regulating related cyclins and Cdks proteins followed by inhibition of DNA incorporation. St. George and Sutherland Medical Research Symposium Sydney, October 2012. Hossain L, Stenzel M, Pourgholami, MH, Morris DL: Albumin Nanoparticles for Delivery of Albendazole in 94 Ovarian Cancer: Uptake of Albendazole loaded Albumin Nanoparticles in Ovarian Cancer. Drug Delivery Australia, Melbourne, November 2012. Mekkawy AB, Pourgholami MH, Morris DL: Suppression of growth factors-induced migration in human cells. St. George and Sutherland Medical Research Symposium Sydney, October 2012. Pillai K, Akhter J, Chua TC, Morris DL. A revolutionary method for the treatment of pseudomyxoma peritonei. St. George and Sutherland Medical Research Symposium, Sydney, October 2013. Community Engagement Pourgholami MH – Member of Scientific Committee St George Medical Foundation. 2013 - International Ataie-Kachoie, P., Morris, D. L., & Pourgholami, M. H. (2013/04/15/). Minocycline abrogates IL-6 signaling and inhibits migration, invasion and adhesion capacity of ovarian cancer cells. Paper presented at the 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC. 2013 - National Amini, A., Moghaddam, S. M., Ehteda, A., & Morris, D. L. (2013). Cytotoxic effects of pineapple bromelain in gastrointestinal carcinoma cell lines. Paper presented at The 25th Lorne International Cancer Conference, Lorne, Australia. Ataie-Kachoie P, Badar S., Morris DL., Pourgholami MH.: New implication for an old drug: minocycline as a potential candidate for ovarian cancer. The 25th Lorne International Cancer Conference, Lorne, Australia, February. Ataie-Kachoie P, Badar, S., Morris DL., Pourgholami MH.: Minocycline down-regulates NF-BB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of NF-BB activation in ovarian cancer: in vitro and in vivo studies. St. George and Sutherland Medical Research Symposium. Sydney, October 2013. Bahrami F, Morris DL, Pourgholami MH: Monepantel suppress ovarian cancer cell proliferation by arresting cell cycle at G1 and down regulating cyclins A, E, Cdk 2 and 4. The 25th Lorne International Cancer Conference, Lorne, Australia, February 2013. Bahrami F, Morris DL, Pourgholami MH: Monepantel suppress ovarian cancer cell proliferation by arresting cell cycle at G1 through AMPK/ ERK / p70S6k pathway and down regulating cyclin D1, E, Cdk 4 and 2. St. George and Sutherland Medical Research Symposium, Sydney, October 2013. Hossain L, Pourgholami MH, Liang R, Morris DL, Stenzel M: Delivery of albendazole for the treatment of ovarian cancer. Lowy Cancer Symposium, Sydney, May 2013. Moghaddam, S. M., Amini, A., & Morris, D. L. (2013). Human epithelial ovarian cancer cell lines differentially express Sprouty proteins 1, 2 and 4. Paper presented at the 25th Lorne International Cancer Conference, Lorne, Australia. 95 > Department of Orthopaedic Surgery and Orthopaedic Research Institute Head of Department Original Peer-Reviewed Publications Dr Robert Molnar 2012 Senior Medical Xu Y,Bonar F,Murrell GA. (2012) Enhanced expression of neuronal proteins in idiopathic frozen shoulder. J Shoulder Elbow Surg 21 1391-7. Professor George AC Murrell (Director, Orthopaedic Research Institute) Dr Ashish Diwan Professor Ian Harris Dr Hugh Jones Professor Ron Sekel Dr Wayne Viglione Dr Zoltan Szomor Dr S P Tan Dr Michael Dixon Dr Anthony Keeley Junior Medical Dr Adrian Hughes Dr Edmund O’Leary Dr Alice Chang Research Staff A/Prof Judie Walton Dr Ai Qun Wei Dr Patrick Lam Dr Lijkele Beimers Dr Aminudin Bin Mohammed Shamsudin Dr P S Haen Dr Justine Naylor Dr Pooria Sarrami Ms Helen Badge Ms Deanne Jenkin Ms Elizabeth Armstrong Ms Deanne Jenkins Mr David Mijalkov Mr William du Moulin Research Grants HCF, Ian Harris, Improving services and outcomes for joint replacement patients, $705,000; 2013-2015 Smith and Nephew (Investigator initiated), Dr Robert Molnar, Radiostereometric Analysis (RSA) of The Genesis II Minimally Invasive Surgery (MIS) Tibial Base Plate, $9000; 2008 - 2014) 96 Millar NL,Reilly JH,Kerr SC,Campbell AL,Little KJ,Leach WJ,Rooney BP,Murrell GA,McInnes IB. (2012) Hypoxia: a critical regulator of early human tendinopathy. Ann Rheum Dis 71 (2) 302-10. Walton JR,Murrell GAC. (2012) Effect of operative time on outcomes of rotator cuff repair. Tech Shoulder Elbow Surg 13 (1) 23-7. Walton JR,Murrell GA. (2012) Clinical tests diagnostic for rotator cuff tear. Tech Shoulder Elbow Surg 13 (1) 17-22. Shepherd H,Murrell GAC. (2012) Use of synthetic patches as tendon substitutes in knotless arthroscopic repairs of massive rotator cuff tears. Tech Shoulder Elbow Surg 13 (1) 32-5. Le Lievre HMJ,Murrell GAC. (2012) Long-term outcomes of arthroscopic capsular release for idiopathic adhesive capsulitis. J Bone Joint Surg (Am) (94) 1208-16. Peters K,McCallum S,Briggs L,Murrell GA. (2012) A comparison of the outcomes of arthroscopic repair of partial- versus full-thickness rotator cuff tears. J Bone Joint Surg (Am) 94 1078-85. Murrell GAC. (2012) Advances in rotator cuff repair undersurface repair. Tech Shoulder Elbow Surg 13 (1) 23-7. Bokhari AR,Murrell GA. (2012) The role of nitric oxide in tendon healing. J Shoulder Elbow Surg 21 (2) 238-44. Kelly MJ,Andres B,Briggs L,Lam P,Ali R,Murrell GAC. (2012) Ultrasound-guided placement of a localization wire for arthroscopic treatment of calcific tendonitis. Tech Shoulder Elbow Surg 13 (3) 134-7. Millican J,Murrell GAC. (2012) Can handheld dynamometers diagnose partial-thickness rotator cuff tears? Shoulder and Elbow 4 (2) 100-5. Wu XL,Briggs L,Murrell GA. (2012) Intraoperative determinants of rotator cuff repair integrity: an analysis of 500 consecutive repairs. Am J Sports Med 40 (12) 2771-6. Walton JR,Murrell GAC. (2012) A two-year clinical outcomes study of 400 patients, comparing open surgery and arthrosopic for rotator cuff repair. Bone Joint Res 1 210-17. Millar NL,Murrell GA. (2012) Heat shock protein in tendinopathy: novel molecular regulators. Mediators of Inflammation (2012) (Article ID 436203) 1-7. Kishen TJ, Lindstrom ST, Etherington G, and Diwan AD (2012). Veillonella spondylodiscitis in a healthy 76-year-old lady. Eur Spine J.; 21 Suppl 4: 413-7. Mitchell SJ, Hilmer SN, Kirkpatrick CM, Hansen RD, Williamson DA, Singh NA, Finnegan TP, Allen BJ, Diamond TH, Diwan AD, Lloyd BD, Smith EU, and Fiatarone Singh MA (2012). Estimation of lean body weight in older women with hip fracture. J Nutr Health Aging.; 16: 188-92. Molnar RB, Jenkin DE, Millar MJ, Campbell D, Harris IA Feb, (2012). The Australian arthroplasty thromboprophylaxis survey. J Arthroplasty, Feb 27(2):1739. Hogg M, Molnar R, Shidiak L, Gillies M, May 1, (2012);. Comparison of a 3-Hole Locking Plate With Angled Screws to a Standard 4-Hole Hip Plate: A Finite Element Study. Journal of Bone & Joint Surgery, British Volume, 94-B(SUPP XXIII):217. Small T, Cairns P, Proctor J, Molnar R. A, May 1, (2012) Pilot Study to Assess a Multimodal Approach to Short Stay Arthoplasty. Journal of Bone & Joint Surgery, British Volume;94-B(SUPP XXIII):44. Molnar RB, Jenkin DE, Millar MJ, Campbell D, Harris IA Feb (2012),The Australian Arthroplasty Thromboprophylaxis survey, Journal Arthroplasty;27(2):173-9. Gnanenthiran SR, Adie S, Harris IA, Feb (2012), Nonoperative versus Operative Treatment for Thoracolumbar Burst Fractures Without Neurologic Deficit: A Meta-analysis Clin Orthop Relat Res.;470(2):567-77. Mitchell R, Watson WL, Curtis K, Harris I, McDougall P, (2012) Jan, Difficulties in establishing long-term trauma outcomes data collections. Could trauma outcomes be routinely monitored in New South Wales, Australia: piloting a 3 month follow-up? Injury.;43(1):96-102. Adie S, Dao A, Harris I A, Naylor J M, Mittal R, (2012) Sep Satisfaction with joint replacement in public vs private hospitals: a cohort study, ANZ J Surg.;82(9): 616-624. Arora M, Harris I A, McEvoy L, Mittal R, Naylor J M, (2012) The effect of a single passive intervention to improve patient satisfaction in an orthopaedic service Open Journal of Orthopedics;2(2): 33. Walton JR (2012) Evidence that ingested aluminum additives contained in processed foods and alum-treated drinking water are a major risk factor for Alzheimer’s disease. Curr Inorg Chem 2, 19-33. Walton JR (2012) Aluminum disruption of calcium homeostasis and signal transduction resembles change that occurs in aging and Alzheimer’s disease. J Alzheimers Dis 29, 255-273. Walton JR (2012) Cognitive deterioration and assocoiated pathology induced by chronic low-level aluminum ingestion in a translational rat model provides an explanation of Alzheimer’s disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis, 91947, 17 pp doi:10.1155/2012/914947 (Open access). 2013 Tham ERX,Briggs L,Murrell GAC. (2013) Ultrasound changes after rotator cuff repair - is supraspinatus tendon thickness related to pain? J Shoulder Elbow Surg 22 (8) e8-e15. Millar NL,Murrell GA,McInnes IB. (2013) Alarmins in tendinopathy: unravelling new mechanisms in a common disease. Rheumatology (Oxford) 52 (5) 769-79. Ronquillo J,Lam P,Murrell GAC. (2013) Arthroscopic ePTFE patch repair for irrepairable rotator cuff tears. Part 1: surgical technique and biomechanical comparison of two suture techniques at the patch to tendon interface. Tech Shoulder Elbow Surg 14 (2) 29-32. Ronquillo JC,Lam P,Murrell GAC. (2013) Arthroscopic ePTFE patch repair for irrepairable rotator cuff tears. Part 2: preliminary clinical results. Tech Shoulder Elbow Surg 14 (2) 33-41. Ronquillo J,Briggs L,Lam P,Murrell GAC. (2013) Morphological changes of synthetic (ePTFE) interpositional patch repair for massive irrepairable rotator cuff tear; a 97 short term prospective clinical study. Tech Shoulder Elbow Surg 14 (3) 73-80. Journal of Biomimetics, Biomaterials & Tissue Engineering. 2013; 13: 97-118. McFarland EG,Maffulli N,Del Buono A,Murrell GAC,Garzon-Muvdi J,Petersen SA. (2013) Impingement is not impingement: the case for calling it “Rotator Cuff Disease”. Muscles Ligaments Tendons J 3 (3) 196-200. Mathew J, Singh S, Garis S, and Diwan A (2013). Backing up the stories: The psychological and social cost of low back pain. Int J Spine Surgery. 2013; 7: 29-38. Shepherd H,Lam P,Murrell GAC. (2013) Synthetic patch rotator cuff repair- a 10-year follow-up. J Shoulder Elbow Surg 6 (1) 35-9. Murrell GA. (2013) Reply: measurement of posterior capsule thickness. J Shoulder Elbow Surg 22 (8) e17. Beimers L,Murrell GAC. (2013) Arthroscopic capsular release for idiopathic adhesive capsulitis - surgical technique. JBJS Essential Surgical Technique 3(1):e2. Bhattacharjee S, Zhao Y, Hill JM, Culicchia F, Kruck TPA, Percy ME, Pogue AI, Walton JR, Lukiw WJ (2013) Selective accumulation of aluminum in cerebral arteries in Alzheimer’s disease (AD). J Inorg Biochem 126, 35-37. Diwan AD, Leong A, Appleyard R, Bhargav D, Fang ZM, and Wei A (2013). Bone morphogenetic protein-7 accelerates fracture healing in osteoporotic rats. Indian J Orthop. 2013; 47: 540-6. Oliver RA, Yu Y, Yee G, Low AK, Diwan AD, and Walsh WR (2013). Poor histological healing of a femoral fracture following 12 months of oestrogen deficiency in rats. Osteoporosis Int. 2013; 24: 2581-9. Arora M, Chan EK, Gupta S, and Diwan AD (2013). Polymethylmethacrylate bone cements and additives: A review of the literature. World J Orthop. 2013; 4: 67-74. Arora M, Diwan AD, and Harris IA (2013). Burnout in orthopaedic surgeons: a review. ANZ J Surg. 2013; 83: 512-5. Grigg M, Arora M, and Diwan AD (2013). Australian medical students and their choice of surgery as a career: a review. ANZ J Surg. 2013. Grigg M, Diwan AD (2013). The painful back; elements of current understanding. Karnataka Medical Journal. 46:3-6. Arora M, Asha S, Chinnappa J, and Diwan AD (2013). Burnout in emergency medicine physicians. Emerg Med Australasia. 2013; 25: 491-495. Chamoli U, Diwan AD, and Tsafnat N (2013). Pedicle screwbased posterior dynamic stabilizers for degenerative spine: In vitro biomechanical testing and clinical outcomes. J Biomed Mater Res A. Epub Date 2014/01/03 Zhou F, Wei A, and Diwan A (2013). An overview of intervertebral disc degeneration and evaluation of the chondrogenic and chemotactic potential of CDMP-2. 98 Arora M, Diwan AD, Harris IA (2013). Burnout in orthopaedic surgeons: a review. ANZ J Surg. 2013 Jul;83(78):512-5. Harris I A, Harris A M, Naylor J M, Adie S, Mittal R, Dao A T (2013), Discordance Between Patient and Surgeon Satisfaction After Total Joint Arthroplasty Journal of Arthroplasty Volume 28, Issue 5, May 2013, Pages 722–727. Buhagiar MA, Naylor J M, Harris I A, Xuan W, Kohler F, Wright R J and Fortunato R (2013), Hospital Inpatient versus Home-based rehabilitation after knee arthroplasty (The HIHO study): study protocol for a randomized controlled trial Trials 2013, 14:432. Walton JR (2013) Aluminum’s involvement in the progression of Alzheimer’s disease. J Alzheimers Dis 35, 7-43. (Open access) Presentations at Scientific Meetings and Conferences 2012- International Murrell GAC, The 2nd International Symposium on Musculoskeletal System and Pain, Sapporo, Japan. Lecture: Advances in the diagnosis and management of rotator cuff tears. Murrell GAC, Funabashi Orthopaedic Sports Medicine Center, Funabashi, Japan; Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan. Lecture: Rotator cuff healing and repair. Murrell G A C, 17th FINA World Sports Medicine Congress, Istanbul, Turkey Lecture: Aetiology and Management of Shoulder Problems in Swimming Workshop: Shoulder assessment. Harris I A, American Academy of Orthopaedic Surgeons Annual Scientific Meeting, Tourniquet application only during cement fixation in total knee arthroplasty: a doubleblind randomized controlled trial Pulsed electromagnetic field stimulation for acute tibia fractures: a multicenter double blind randomized controlled trial. Harris I A, AO Difficult Fracture Symposium – Korea, Timing of surgery for hip fractures in the elderly Bisphosphonates: weighing the risks and benefits. Peters K,Briggs L,Murrell GAC. (2012). Ultrasound-guided versus blind subacromial corticosteroid injection for subacromial impingement. 2012 AAOS Annual Meeting, February 7-11, San Francisco, CA. Poster P315. shoulders. Australian Orthopaedic Association Annual Scientific Meeting, October 7-11, (2012), Sydney. Wu X,Briggs L,Murrell GAC. (2012) Intra-operative determinants of rotator cuff repair integrity: an analysis in 500 consecutive repairs. 2012 AAOS Annual Meeting, February 7-11, San Francisco, CA. Paper 62. Le Lievre HM,Murrell GAC. (2012) Long-term outcomes of arthroscopic capsular release for frozen shoulder. Australian Orthopaedic Association Annual Scientific Meeting, October 7-11, Sydney. Peters K,Murrell GAC. (2012) Permanent outperforms biodegradable anchors for arthroscopic stabilization. 2012 AAOS Annual Meeting, February 7-11, San Francisco, CA. Paper 201. Peters K, Khoo J K, Wei A Q, Ronquillo J, Lam P, Murrell GAC. (2012) Permanent outperforms biodegradable anchors for arthroscopic shoulder stabilization. Australian Orthopaedic Association Annual Scientific Meeting, October 7-11, 2012, Sydney. Dines J,Bedi A,Rodeo S,Murrell GAC. (2012) Biologic Augmentation of Tendon-Bone Healing in the 21st Century: Where are we now? Instructional Course Lecture 224. AAOS annual meeting, San Francisco, CA. Wu X,Briggs L,Murrell GAC. (2012) Intra-operative determinants of rotator cuff repair integrity: an analysis in 500 consecutive repairs. AOSSM 2012 Specialty Day, February 11, 2012, San Francisco, CA. Paper. Peters K,Murrell GAC. (2012) Permanent outperforms biodegradable anchors for arthroscopic stabilization. Open Meeting of the American Shoulder and Elbow Surgeons, Specialty Day, February 11, 2012, San Francisco, CA. Paper. Le Lievre HM,Murrell GAC. (2012) Excellent long-term outcomes of arthroscopic capsular release for frozen shoulder. Open Meeting of the American Shoulder and Elbow Surgeons, Specialty Day, February 11, 2012, San Francisco. Paper. (Finalist Neer Award). Tham L,Briggs L,Murrell GAC. (2012) Ultrasound changes after rotator cuff repair – is supraspinatus tendon thickness related to pain? Orthopaedic Research Society 2012 Annual Meeting in San Francisco, California, February 4-7. Poster. Peters K,Murrell GAC. (2012) Permanent outperforms biodegradable anchors for arthroscopic stabilization. 8th Biennial AAOS/ASES Shoulder and Elbow Meeting May 3-5, 2012, Boca Raton Resort & Club, Boca Raton/Miami, Florida. Paper. Dines J,Bedi A,Rodeo S,Murrell GAC. (2012) Biologic Augmentation of Tendon-Bone Healing in the 21st Century: Where are we now? Instructional Course Lecture. AAOS annual meeting, Chicago, IL. 2012 - National Murrell GAC, Lecture: Ultrasound and advances in rotator cuff repair. Australian Sonographers Association Annual Meeting Canberra 2012. Kurz AK, Kelly MJ, Briggs L,Murrell GAC (2012) Effect of surgeon-sonographer intaraction on ultrasound diagnosis of rotator cuff tears: a five-year cohort study in 775 Beimers L,Lam P,Murrell GAC. (2012) The effects of reinforcing rotator cuff repairs with ePTFE augmented sutures. 2012 Biennial Shoulder & Elbow Society of Australia, Brisbane, Queensland. Shepherd H,Ronquillo J,Lam P,Murrell GAC. (2012) ePTFE patch repair for irrepairable rotator cuff tears. 2012 Biennial Shoulder & Elbow Society of Australia, Brisbane, Queensland. Lam P,Shepherd HM,Murrell GAC. (2012) Biomechanical analysis of Fiber Tape versus Fiberwire in rotator cuff repair. The St George and Sutherland Hospital Medical Research Symposium, October 2012. Khoo J,Wei AQ,Lam P,Ronquillo J,Murrell GAC. (2012) Biomechanics and cytotoxicity of suture anchors used in labral repairs. The St George and Sutherland Hospital Medical Research Symposium, October 2012. Kroslak M,Murrell GAC. (2012) Surgical treatment of lateral epicondylitis: a prospective., randomised, placebo controlled pilot study. The St George and Sutherland Hospital Medical Research Symposium, October 2012. Lam PH,Hansen K,Keighley G,Briggs L,Murrell GAC. (2012) A randomised double blined clinical control trial evaluating the effectiveness of daily vibration following arthroscopic rotator cuff repair. The St George and Sutherland Hospital Medical Research Symposium, October 2012. Poster. Le BTN,Wu X,Lam PH,Murrell GAC. (2012) Factors predicting rotator cuff re-tear: An analysis of 1000 consecutive rotator cuff repairs. The St George and Sutherland Hospital Medical Research Symposium, October 2012, Poster. Tham L,Briggs L,Murrell GAC. (2012) Ultrasound changes after rotator cuff repair – is supraspinatus tendon thickness related to pain? The St George and Sutherland Hospital Medical Research Symposium, October 2012. Poster. Shepherd HM,Lam PH,Murrell GAC. (2012) Interpositoin PTFE patch repair vs direct rotator cuff repair in an ovine model. The St George and Sutherland Hospital Medical Research Symposium, October 2012. Poster. 99 Briggs L, Peters K, Murrell GAC. (2012) Ultrasound-guided versus blind subacromial corticosteroid injection for subacromial impingement. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 373. Kurz A,Kelly M,Briggs L. Murrell GAC. (2012) Adrian Kurz: Effect of surgeon-sonographer interaction on ultrasound diagnosis of rotator cuff tears: A five-year cohort study in 775 shoulders. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 373. Molnar R, Computer Navigated Total Hip Arthroplasty - Can It Be Simple And Accurate? The Annual Scientific Meeting of the Arthroplasty Society, June (2012), Melbourne. Harris I A, ACI 2nd Annual Musculoskeletal Network Forum: Pre, peri and post-operative care in primary total hip and knee replacement: a review of the evidence. Sydney, 4 May 2012. Harris I A, NSW AOA Annual Scientific Meeting 2012: Sydney 17 August 2012. • Complications and diagnostic investigations after hip and knee arthroplasty in English proficient and nonEnglish proficient patients • Is centre-based care superior to a home program after total knee replacement? A single blind randomized controlled trial • Why don’t people participate in randomized trials in surgery? • Mail versus telephone administration for Oxford hip and knee scores • ANZ Hip Fracture Registry • The effect of a single passive intervention to improve patient satisfaction in an orthopaedic service • Are subacute outcomes following TKR and THR different in patients who have limited English proficiency? Kroslak M,Murrell GAC. (2012) Surgical treatment of lateral epicondylitis: A prospective, randomised, blinded, placebo controlled pilot study. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 374. • Total hip replacement in haemodialysis and renal transplant patients – a systematic review • Dose dependent effects of intra-articular injection of tranexamic acid on bleeding in total knee arthroplasty. Lam PH,Shepherd H,Murrell GAC (2012). Biomechanical comparison of two arthroscopic rotator cuff repair techniques using synthetic scaffolds as a bridging device in an ovine model. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 157. • Rates of lumbar spine surgery, revision and mortality rates for NSW, 2000-2008 • Pulsed electromagnetic field stimulation for acute tibia fractures: a multicentre double blind randomised controlled trial • Trends in arthroscopic surgery and conversion to TKR: NSW 2000-2008 Leason S,Briggs L, Murrell GAC (2012) The effectiveness of ultrasound in diagnosis of adhesive capsulitis: A pilot study. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 158. • Predictors of discordance in patients and surgeon satisfaction after hip and knee replacement • Is a 30 minute walk test useful after a knee replacement? • Why don’t people participate in randomized trials in surgery? Le B,Wu X,Murrell GAC (2012). Factors predicting rotator cuff re-tear rate: An analysis of 1000 consecutive rotator cuff repairs. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 373. Lam PH, Hansen K, Keighley G, Briggs L,Murrell GAC. (2012) A randomised double blinded clinical control trial evaluating the effectiveness of daily vibration following arthroscopic rotator cuff repair. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 374. 100 Harris I A, AOA Annual Scientific Meeting: Sydney, 8-11 October 2012 • The evidence base for common orthopaedic procedures Harris I, 2nd Annual Whitlam Orthopaedic Research Centre Symposium August 10, 2012, Liverpool Hospital NSW • ANZ Hip Fracture Registry • • Total hip replacement in haemodialysis and renal transplant patients – a systematic review Patient satisfaction after total joint replacement: private versus public • Spine surgery outcomes in a workers compensation environment Elective total hip and knee replacements: a review of the evidence • Dose dependent effects of intra-articular injection of tranexamic acid on bleeding in total knee arthroplasty Patient preference for rehabilitation after joint replacements • Peri-articular steroid injection in total knee arthroplasty: a prospective double blinded randomized controlled trial Mail versus telephone administration for Oxford hip and knee scores • The evidence base for common orthopaedic procedures Mortality after surgery in NSW. • The CROSSBAT trial: lessons for conducting multicentre randomized trials in orthopaedics in Australia Harris I A, Australian Physiotherapy Association Annual Meeting: Improving access to elective joint replacement surgery: a waitlist cohort. Melbourne, October 2013. • Are orthopaedic randomized trials generalisable? A comparison with other surgical specialties Harris I A, Ingham Institute Annual Research and Teaching Showcase: Sydney, November 2013 • Scientific and reporting quality of orthopaedic randomized trials: a comparison with other surgical specialties • Monitoring hip or knee arthritis: measurement error in patient outcomes • Tranexamic Acid to reduce blood transfusion in hip fracture surgery • Inter-rater reliability in clinical registry data collection • Accuracy and completeness data audit of the Arthroplasty Clinical Outcomes Registry • Opioid dependence after major orthopaedic trauma • Opioid dependence after minor motor vehicle trauma. • • • • Emergency pelvic fracture care: acute interventions are required in haemorrhagic shock (debate) Harris I A, AOA Continuing Orthopaedic Education: Melbourne, 1-3 March 2013 • Orthopaedic Trauma: Distal radius fractures – internal fixation is rarely necessary • The CROSSBAT Trial: lessons learned from a multicentre RCT. Harris I A, AOA Continuing Orthopaedic Education “ShortSharp” meeting - How I got into research: Sydney, 26 July 2013 Harris I A, NSW AOA Annual Scientific Meeting: Sydney, 23 August 2013 • Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study • Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide crosssectional study • ACORN: The Arthroplasty Clinical Outcomes Registry, NSW – what is it and why do we need it? • A comparison of alignment using patient specific instruments, computer navigation and conventional instrumentation in total knee Arthroplasty. Harris I A, Osteoarthritis and viscosupplementation experts’ debate: The clinical evidence against viscosupplementation: Sydney, 27 June 2013 Harris I A, Raising Expectations in Rheumatology, Surgical recommendations – be wary: Melbourne, 28 July 2013. Harris I A, St George Hospital Osteoarthritis Symposium: ACORN: The Arthroplasty Clinical Outcomes Registry, NSW – what is it and why do we need it?, The clinical evidence against injection therapy for osteoarthritis of the knee, Kogarah. Harris I A, SWSLHD Allied Health Research Forum, Improving access to elective joint replacement surgery: a waitlist cohort. Liverpool NSW. Harris I A, Western Orthopaedic Group of Surgeons Annual Meeting, The clinical evidence against injection therapy for osteoarthritis of the knee. Bowral, 30 November 2013. 101 Harris I A, Workers Compensation Conference, Spine surgery and injections: the case for restraint. Sydney, 24 August 2013. 2013 - International Murrell GAC, 12th International Congress of Shoulder and Elbow Surgery (ICSES 2013), Nagoya, Japan. Lecture: Biological and synthetic patches for irreparable rotator cuff tears. Murrell GAC, 36th Annual Scientific Meeting Singapore Orthopaedic Association, Singapore, 8-12 October 2013 Lecture: Permanent versus biodegradable anchors for arthroscopic stabilisation for traumatic anterior shoulder instability. Lecture: Rotator cuff tears - pathology and imaging. Lecture: Undersurface rotator cuff repair. Debate: Single row (*) versus double row for rotator cuff repair. Symposium: Rotator cuff repair with knotless system. Lecture: Biological and synthetic patches for irreparable rotator cuff tears. Arora M, Diwan AD, Harris IA; “Burnout among orthopaedic surgeons”. Indian Orthopaedic Association Conference 2013 - Podium Presentation, India. Le BTN, Wu X, Lam PH, Murrell GAC. (2013) Factors predicting rotator cuff re-tear: An analysis of 1000 consecutive rotator cuff repairs. Open Meeting of the American Shoulder and Elbow Surgeons, held on Specialty Day, Saturday, March 23, 2013, in Chicago, IL. Le BTN,Wu X,Lam PH,Murrell GAC. (2013) Factors predicting rotator cuff re-tear: An analysis of 1000 consecutive rotator cuff repairs. AOSSM 2013 Specialty Day, March 23, 2013, Chicago, IL. Paper 16. Peters K; Pirapakaran K Murrell GAC (2013) Permanent outperforms biodegradable anchors for arthroscopic shoulder stabilization. AOSSM 2013 Specialty Day, March 23, 2013, Chicago, IL. Paper 12. Kurz AK, Kelly MJ, Briggs L, Murrell GAC (2013) Surgeonsonographer interaction on ultrasound diagnosis of rotator cuff tears: Five-Year Study in 775 Shoulders. AAOS Annual Meeting, March 19-23, Chicago, IL, paper 498. Le BTN,Wu X,Lam PH,Murrell GAC. (2013) Factors predicting rotator cuff re-tear: An analysis of 1000 consecutive rotator cuff repairs. AAOS Annual Meeting, March 19-23, Chicago, IL, paper 122. Dines J,Bedi A,Rodeo S,Murrell GAC. (2013) Biologic Augmentation of Tendon-Bone Healing in the 21st Century: Where are we now? Instructional Course Lecture. AAOS Annual Meeting, Chicago, IL. Murrell GAC. (2013) Biological and synthetic patches for irreparable rotator cuff tears. 12th International Congress 102 of Shoulder and Elbow Surgery (ICSES 2013), Nagoya, Japan. Invited paper SSY-1-1. Murrell GAC. Shepherd H,Ronquillo J,Lam P. (2013) ePTFE patch repair for irreparable rotator cuff tears. 12th International Congress of Shoulder and Elbow Surgery (ICSES 2013), Nagoya, Japan. Paper SO-13-3. Murrell GAC, Peters K,Khoo J,Wei A,Ronquillo J,Lam P. Permanent outperforms biodegradable anchors for arthroscopic stabilisation. 12th International Congress of Shoulder and Elbow Surgery (ICSES 2013), Nagoya, Japan. Paper SO-14-9. Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”. Indian Orthopaedic Association Conference 2013 - Poster Presentation, India. Arora M, Diwan AD, et al; “PMMA bone cements and additives: A review of the literature”; 34th SICOT Orthopaedic World Congress – Poster Presentation, India, Abstract number – 33557. Arora M, Diwan AD, et al; PMMA bone cements and additives: Review of literature”. 19th Asian Congress of Surgery and 1st Singhealth Surgical Congress 2013 – Poster Presentation, Singapore. Briggs L,Lam P,Millar N,Murrell GAC. Are the symptoms of calcific tendonitis due to neoinnervation and/or neovascularisation? 2014 AAOS Annual Meeting, March 11-15, New Orleans, Louisiana, Paper 515. Shamsudin A,Lam P,Murrell GAC. Primary versus revision arthroscopic rotator cuff repair - an analysis in 350 consecutive patients. 2014 AAOS Annual Meeting, March 11-15, New Orleans, Louisiana, Poster # P322. Hawthorne J,Carpenter E,Lam P,Murrell GAC. Effect of glenohumeral abduction on supraspinatus repair tension. 2014 AAOS Annual Meeting, March 11-15 in New Orleans, Louisiana, Poster # P315. Shamsudin A,Lam P,Murrell GAC. Primary versus revision arthroscopic rotator cuff repair - an analysis in 350 consecutive patients. 2014 AOSSM Specialty Day, March 11-15 in New Orleans, Louisiana, Paper. Harris I A, AO Masters Course – Current Concepts Interprosthetic and Vancouver C fractures History of pilon fractures Complex tibial plateau fractures and fracture-dislocations. Dubai, 28 September 2013. 2013 - National Murrell GAC, Australian Sonographers Association Annual Meeting, Sydney. Plenary Lecture: Clinical assessment of shoulder and biomechanics, 2013, Sydney. Arora M, Diwan AD, et al; “PMMA bone cements and additives: a review of the literature”; Australian Orthopaedic Association Annual Meeting 2013 - Poster Presentation, Australia. Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; Australian Orthopaedic Association Annual Meeting 2013 - Podium Presentation, Australia. Arora M, Diwan AD, Harris IA; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; Australian Orthopaedic Association Annual Meeting 2013 - Podium Presentation, Australia. Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; New Zealand Orthopaedic Association Annual Meeting 2013 - Poster Presentation, New Zealand. Arora M, Diwan AD, Harris IA; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; New Zealand Orthopaedic Association Annual Meeting 2013 - Poster Presentation, New Zealand. Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; Australian Orthopaedic Association NSW Branch Annual Meeting 2013 - Podium Presentation, Australia. Arora M, Diwan AD, Harris IA ; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; Australian Orthopaedic Association NSW Branch Annual Meeting 2013 - Podium Presentation, Australia. Community Engagement Dr Ashish Diwan, Spinal Surgeon, Department of Orthopaedic Surgery, raised $140,000 donations for the UNSW foundation for spine research and education. 103 > Department of Trauma Services Head of Department Dr Mary Langcake, FRACS, BMBS, BSc Senior Medical Dr Christine Bowles, MBBS, FACEM Dr Anthony Chambers, BSc, MBBS, MS, FRACS Dr Anthony Morgan, MD, PhD Nursing Kate Curtis, CNC, RN, MNurs (Hons), PhD Conjoint Associate Professor, February 2010 – June 2017 St George Clinical School, University of NSW Honorary Professorial Fellow, June 2010 – June 2014 The George Institute for Global Health Visiting Associate Professor, May 2013 – May 2015 Faculty of Health Sciences and the Organisation and Delivery of Care Research Group University of Southampton, England Taneal Wiseman, CNC Belinda Kennedy, CNS Liz Walter, CNS Sarah Kourouche, CNS Jane Leroi, RN Belinda Munroe, CNS Research Grants Motor Accidents Authority of NSW, NSW Small Grants round. Kate Curtis, Lynne Roberts, Mary Langcake. Improving the care and outcomes of patients with blunt chest injury. $14,814, 2013-14. Motor Accidents Authority of NSW, NSW Small Grants round. Kate Curtis, Helen Goldsmith, Mary Langcake. Improving outpatient pain management. $13, 676, 2013-14. Motor Accidents Authority of NSW, NSW Small Grants round. Taneal Wiseman, Kate Curtis, Sandra West. E-learning to improve trauma care on the wards. $14, 717, 2013-14. Emergency Care Institute, Kate Curtis, Margaret Murphy, Jennifer Hardy, Melinda Lewis, Luke Strachan & Tom Buckley. HiRAID: Evaluation of an emergency nursing assessment framework on patient assessment and documentation: A pilot study, $99,457, 2012-14. 104 Day of Difference Foundation, Kate Curtis, Kim Foster, Rebecca Mitchell, Paediatric Critical Injury Research Program , $574,223, 2013-2018. Research Projects in Progress Does the implementation of a Chest Injury protocol (ChIP) for patients with blunt thoracic trauma reduce complications and improve outcomes for patients? Kate Curtis, Stephen Asha, Annelise Unsworth & Mary Langcake. The CONFORM Study - PrediCtors Of analgesia use and regimeN adherence FollOwing discharge after Major trauma. Helen Goldsmith, Kate Curtis & Andrea McCloughen. Exploring the Role of the Wound Care Clinical Nurse Consultant in a Tertiary Referral Hospital. Matthew Dutton, Mary Chiarella & Kate Curtis. Evaluation of an emergency nursing assessment framework on patient assessment and documentation: A feasibility pilot. Belinda Munroe, Kate Curtis & Thomas Buckley. Life threatening injury in young people: A mixed methods study. Rebekah Ogilvie, Kim Foster, Kate Curtis, Andrea McCloughen. Depression, Anxiety and Stress in Major trauma patients Taneal Wiseman, Kate Curtis &Kim Foster . What makes an Emergency Nurse? Personality Types/ characteristics . Belinda Kennedy, Kate Curtis & Donna Waters. The profile rural trauma presentations. Maryanne Sewell & Kate Curtis. The impact of trauma nursing roles on patient outcomes Liz Walter & Kate Curtis. Cost of Major Trauma in NSW. University of Sydney: Nursing, Health Sciences, UNSW TARS, The George Institute for Global Health, NSW Institute of Trauma and Injury Management. Kate Curtis, Deborah Black, Doris Lam, Rebecca Mitchell & John Myburgh. The scribe nurse in major trauma: Does level of experience improve quality of documentation and leadership? Kate Curtis, Alana Clements, Leanne Horvat & Ramon Shaban. Subdural Haemmorrhage in older persons: a comparison of outcomes between those on anticoagulants at the time of injury and those not. Stephen Asha, Jaenette Keady, Kate Curtis & Saeed Kohan. Integrative Literature review on successful models of care delivery for severely injured children. Kate Curtis, Kim Foster, Rebecca Mitchell. The incidence of paediatric trauma in Australia. Kate Curtis, Kim Foster, Rebecca Mitchell. What are the levels of emotional distress, contributing factors and unmet needs of parents of injured children throughout the trauma journey? Kate Curtis, Kim Foster, Rebecca Mitchell. How is care provided for paediatric trauma patients and their families? Kate Curtis, Kim Foster, Rebecca Mitchell. What are the needs of parents of severely injured children in Australia? Kate Curtis, Kim Foster, Rebecca Mitchell. Improving outcomes in children suffering major trauma Kate Curtis, Kim Foster, Rebecca Mitchell. Original Peer-Reviewed Publications 2012 Asha SE, Curtis KA, Taylor C, Kwok A. Patient-controlled analgesia compared with interval analgesic dosing for reducing complications in blunt thoracic trauma: a retrospective cohort study. Emergency Medicine Journal, 2012. doi:10.1136/emermed-2012-201980 Curtis K, Leonard E: The Trauma Nurse Coordinator in Australia and New Zealand: Demographics, Role and Professional Development. Journal of Trauma Nursing 2012, 19(4):214-220. Ogilvie R, Foster K, McCloughen A & Curtis K. The experience of surviving life-threatening injury: a qualitative synthesis. International Nursing Review, 2012, 59(3):312320. Taylor C, Jan S, Curtis K, Tzannes A, Li Q, Palmer C & Myburgh J (2012). The cost-effectiveness of physician staffed Helicopter Emergency Medical Service (HEMS) transport to a major trauma centre in NSW, Australia. Injury, 43; 1843–1849 Dutton M & Curtis K (2012). Well-wound therapy: use of NPWT to prevent laparotomy breakdown. Journal of Wound Care, 21(8);386-8 Willenberg L, Curtis K, Taylor C, Jan S, Glass P, Myburgh J (2012). The variation of acute treatment costs of trauma in high-income countries. BMC Health Services Research, 12(1):267 Curtis K, Mitchell R.J, Chong S.S, Balogh Z.J, Reed D.J, Clark P.T, D’Amours S, Black D.A, Langcake M.E, Taylor C.J, McDougall P.A, Cameron P.A (2012). Injury trends and mortality in severely injured adults in NSW. Medical Journal of Australia, 197(4): 233-237 Clements A & Curtis K (2012). What is impact of nursing roles in hospital patient resuscitation? Australasian Emergency Nursing Journal, 15(2): 108-115. Mitchell R, Curtis K, Fisher M (2012). Understanding trauma as a men’s health issue: gender differences in traumatic injury presentations at a level 1 trauma centre in Australia. Journal of Trauma Nursing, 19(2), 80-88. Curtis K, Caldwell E, Delprado A, Munroe B (2012). Traumatic Injury in Australia and New Zealand. Australasian Emergency Nursing Journal, 15(1); 45-54. Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, Steel T, Nau T (2012). Road Trauma, patterns of injury and mortality in an Australian trauma centre. Journal of the Australasian College of Road Safety, 23(1):21-28. Asha S, Curtis KA, Grant N, Taylor C, Lo S, Smart R, et al (2012). Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a panscan protocol. Emergency Medicine Australasia. 24(1):43-51 Mitchell R, Watson W, Curtis K, Harris I & McDougall P (2012). Difficulties in establishing long-term trauma outcomes data collections. Could trauma outcomes be routinely monitored in New South Wales, Australia: piloting a 3 month follow-up? Injury, 43(1): 96-102. 105 2013 Malaysia Wiseman T, Foster K & Curtis K. Mental health following traumatic physical injury: an Integrative literature review. Injury. 2013;44(11):1383-1390 Langcake M, Invited Speaker. Training Teams for Trauma, Surgical Education Program. RACS 81st Annual Scientific Congress, 10 May 2012, Malaysia. Taylor C, Curtis K, Jan S & Newcombe M. Helicopter Emergency Medical Services (HEMS) over-triage and the financial implications for major trauma centres in NSW, Australia. BMC Emergency Medicine June 2013, 13:11 Langcake M, Invited Speaker. The Problems with Total Body Scans, Trauma Surgical Program. RACS 81st Annual Scientific Congress, 10 May 2012, Malaysia. Curtis K, Chan D, Lam M, Mitchell R, King K, Leonard L, D’Amours S, Black D. The profile and cost of major trauma in older people in New South Wales, Australia. Australasian Journal on Ageing (online June 2013 DOI: 10.1111/ajag.12059) Mitchell R, Curtis K, Holland AJ, Balogh ZJ, Evans, J, Wilson K (2013). Acute costs and predictors of higher treatment costs for major paediatric trauma in New South Wales, Australia. Journal of Paediatrics and Child. 49(7):557-63 Munroe B, Curtis K, Considine J, Buckley T. The Impact Structured Patient Assessment Frameworks Have on Patient Care: An Integrative Review. Journal of Clinical Nursing (2013 Early online DOI: 10.1111/jocn.12226) McIntosh AS, Curtis K, Rankin T, Cox M, Pang TY, McCrory P & Finch C. Associations between helmet use and brain injuries amongst injured pedal- and motor-cyclists: A case series analysis of trauma centre presentations. Journal of the Australasian College of Road Safety 2013; 24, 11-20. Dinh M, Curtis K, Ivers R. The effectiveness of helmets in reducing head injuries and hospital treatment costs in Sydney, Australia. A multicentre study. Medical Journal of Australia 2013; 198 (8): 415-417 Mitchell R, Curtis K, Chong S, Holland AJ, Soundappan SVS, Wilson KL, Cass DT. Comparative analysis of trends in paediatric trauma outcomes in Australia. Injury, 2013, 44:97-103. Presentations at Scientific Meetings and Conferences 2012 International Dutton M, Chiarella M & Curtis K (2012). The current state of knowledge into role, context of practice and impact of the wound care nurse. 4th Congress of the World Union of Wound Healing Societies Better Care, Better Life, September 2-6, Yokohama Japan Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, Steel T, Nau T (2012). Road Trauma, Patterns of Injury and Mortality in an Australian Trauma Centre. Neurosurgery Section of the Royal Australasian College of Surgeons’ Annual Scientific Congress., 7 – 10 May Kuala Lumpur, 106 2012 National Dutton M, Chiarella M & Curtis K. The current state of knowledge into role, context of practice and impact of the wound care nurse. 10th National Australian Wound Management Association Conference. Sydney Convention & Exhibition Centre18 -21 March. Clements A, Curtis K, Holzhauser K, Horvat L. The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. 10th International Conference for Emergency Nursing, 10-12th October, Hobart. Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury trends and mortality in adult patients with major trauma in New South Wales, Australia, AMDIG 2012 Unlocking the Value of Mortality Data Workshop. 13 November, Sydney. Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury trends and mortality in adult patients with major trauma in NSW, 10th International Conference for Emergency Nursing, 10-12th October, Hobart . Munroe B, Curtis K, Buckley T, Considine J. The impact of a structured patient assessment on patients and clinicians. 10th International Conference for Emergency Nursing, 1012th October, Hobart. Curtis K, Lam M, Mitchell R, Black D et al. Acute costs and predictors of higher treatment costs of trauma in New South Wales, Australia. Trauma 2012, 26-28th October, Perth. Leonard E, Curtis K. A snapshot: Resources currently available in trauma services throughout Australia and New Zealand. Trauma 2012, 26-28th October, Perth. Curtis K, Leonard L. Australian and New Zealand Trauma Nurse Coordinators. Who, what and where? Trauma 2012, 26-28th October, Perth. Clements A, Curtis K, Holzhauser K, Horvat L. The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. Trauma 2012, 26-28th October, Perth. Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury trends and mortality in adult patients with major trauma in NSW. Trauma 2012, 26-28th October, Perth. Curtis K, Invited Speaker. Panel member for moderated discussion entitled ‘2012 Vision, Challenges, and New Frontiers in Emergency Care’ Panel 10th International Conference for Emergency Nursing, 10-12th October, Hobart. Chaired by Jane Hutcheon. Curtis K, Invited Speaker: Swan XX Trauma Conference, Sydney, NSW. July 28-29th 2012 . Langcake M, Panel Session “Dealing with Uncertainty”. Whole Person Care 2nd National Symposium. Doltone House, Sydney. 21 March 2012. Langcake M, Invited speaker Gunshot Wounds Energy Transfer. SWAN XX Trauma Conference, Sydney, NSW. 28 July 2012. 2013 International Chan D, Curtis K, et al. The injury profile and acute treatment costs of major trauma in older people in New South Wales” E-Poster Presentation. Trauma Surgery Section of the Royal Australasian College of Surgeons Annual Scientific Congress, 6 – 10 May 2013, Auckland, New Zealand. Crouch R, Palfrey R, McHale H, Curtis K. Trauma Nurse Coordinators in England, Major Trauma Coordinator National Conference, Salford, England, 25th November 2013. 2013 National Langcake M, Invited Speaker: Inspiring Women in Medicine. Women in Medicine, Parkville 12 August. Curtis K, Invited Speaker: Critical aspects of trauma nursing care 8th Annual Critical Care Conference in the Vineyards, 9 - 10th May. Curtis K, Invited Speaker: Trauma nursing innovations 8th Annual Critical Care Conference in the Vineyards, 9 - 10th May. Community Engagement Langcake M, Teaching on EMST/DSTC. Senior Surgery Program. RACS 81st Annual Scientific Congress, Malaysia. 7 May 2012. Langcake M, Invited Speaker: Consequences of Trauma in Older Patients. Seniors’ Day Injury Prevention Seminar, St George Leagues Club 21 March 2012. Langcake M, Probus Club of Revesby. 24 September 2012. Langcake M Consequences of Trauma in Older Patients. Seniors’ Day Injury Prevention Seminar, St George Leagues Club. 21 March 2013. Langcake M Consequences of Trauma in Older Patients. The Sutherland Hospital’s Clinical Grand Rounds. 29 April 2013. Langcake M Experiences in Afghanistan. Probus Club of Ryde. 28 May 2013. Wiseman T, Pedestrian Trauma. Seniors Day Injury Prevention Seminar, 20 March 2013, Mortdale, NSW. Hosted by Trauma Services, St George Hospital. Ogilvie R, Curtis K, Palmer C, Lam M, McCloughen A, Foster K. Incidence and outcomes of major traumatic injury in the Australian Capital Territory. Canberra Health Annual Research Meeting (CHARM). 20-23rd August. Kennedy B, Curtis K, Waters D. The Personality Characteristics of Emergency Nurses. International Conference for Emergency Nurses, 9-12 October, Melbourne. Ogilvie R, Curtis K, Palmer C, Lam M, McCloughen A, Foster K. Incidence and outcomes of major traumatic injury in the Australian Capital Territory. International Conference for Emergency Nurses, 9-12 October, Melbourne. Mitchell R, Curtis K et al. Acute care costs and predictors of higher treatment costs for major paediatric trauma in NSW. 11th Australasian Injury Prevention & Safety Promotion Conference, 11-13 November Fremantle, Western Australia. Curtis K, Invited Speaker: Management of massive haemorrhage in trauma. International Conference for Emergency Nurses, 9-12 October 2013, Melbourne. 107 > Department of Vascular Surgery Head of Department Dr Eric Farmer MBBS(Hons) FRACS DDY Visiting Medical Officers Dr K Hanel MB BS FRACS DDU Dr L Lemech MB BS FRACS DDU Dr G McMullin MB BS FRACS DDU A/Prof J Iliopoulos MB BS (Hons1) FRACS (Cardiothoracic and vascular) PhD Vascular Trainee Michael Tawadrous, Fellow Victor Bourke, Vascular SET 3 trainee Adrian Tchen, Vascular SET 1 trainee Jill O’Donnell, Fellow Tam Nguyen, Vascular SET 5 trainee Saissan Rajendran, Vascular SET 1 trainee Research Projects in Progress Prospective evaluation of a model to predict outcomes following Endovascular Aortic Aneurysm Repair. Chief Investigator Associate Professor Robert Fitridge, The Queen Elizabeth Hospital, Adelaide, South Australia. St George Principal Investigator L.D. Lemech. Managing trauma in the austere environment: a project for special operations command of the Australian Army. J. Iliopoulos, Chief Investigator; Prof W R Walsh (S & ORL NSW). Adhesions in lumbar spine surgery. J Iliopoulos, Chief investigator Prof. WR Walsh (S&ORL UNSW), (Ongoing). Training of defence force staff in simple tissue handling procedures in a sheep carcus model, J Iliopoulos, Chief Investigator Prof W R Walsh (S & ORL UNSW). Renal Dysfunction in patients undergoing Endoluminal grafting of Abdominal Aortic Aneurysms. Principle Inestigator – Taranei Amir-Nizami. 108 MENTAL HEALTH Mental Health Academic > Unit / School Of Psychiatry 110 > Mental Health Academic Unit / School Of Psychiatry Head of Department Dr Kevin Clarke MBBS(Hons),MHA, Grad Dip FBS, FRANZCP, Conjoint Lecturer UNSW Senior Medical Professor Colleen Loo (MB.BS. (Hons), FRANZCP, MD. School of Psychiatry UNSW; Research Psychiatrist – Black Dog Institute Dr Matthew Boulton, BMBS BSc FRANZCP, Conjoint Associate Lecturer UNSW Dr Anne Camac, MBBS, FRANZCP, Conjoint Lecturer UNSW Dr Mesut Cetiner, MBBS Bsc (Med) (Hons) FRANZCP, Certificate POA & Conjoint Lecturer UNSW Dr Denise Cupina MD, FRANZCP, Conjoint Senior Lecturer UNSW Dr Spencer Duke, BMedSci BM BS MRCPsych FRANZCP, Conjoint Senior Lecturer UNSW Dr Andrew Gerard, MBBS FRANZCP Dr Yana Kay, MBBS, BA, PHD FRANZCP, Conjoint Lecturer UNSW Dr Andrew Pethebridge, MBBS, MM (Ven Sci), MM, FRANZCP, FAChAM, Conjoint Senior Lecturer UNSW Dr Margot Phillips, BABSc (Med) MBBS FRANZCP Dr Anne Wand, Staff Specialist Psychiatrist, Clinical Lecturer, USYD, Conjoint Senior Lecturer UNSW Dr Carmelo Aquilina MD FRCPsych FRANZCP, Senior Clincial Lecturer, USYD Dr Kylie GullifordBSc(Hons) MBBS(Hons) FRANZCP Advanced Certificate Child Psychiatry Child & Adolescent Psychiatrist Conjoint Lecturer UNSW Dr Sam Harvey, Consultant Psychiatrist & Clinical Academic, Consultation Liaison Psychiatry Team Lecturer UNSW Dr Aparna Menon MBBS FRANZCP Staff Specialist Senior Conjoint Lecturer UNSW Mental Health Rehabilitation Unit, The Sutherland Hospital Vocational registrars, advanced trainees Dr Rosalyn Lai (MBBS, MD) Dr Laura Cotiga (MBBS, MD) Dr Alison Bautovich (MBBS, MD) Visiting fellows Dr Patricia Sanchez-Paez (visiting academic) Dr Pablo Puras (visiting academic) 110 Dr Herng Nieng Chan (visiting psychiatrist) Dr Montserrat Porter (visiting academic) Dr Phern Chern Tor (visiting psychiatrist) Senior Research Staff Dr Angelo Alonzo (BA, BSc (Hons), Ph.D) Dr Donel Martin (MClinNeuroPsych; Ph.D; BA (Hons)) Research Staff Dr Veronica Galvez-Ortiz (MBBS, MD, Ph.D) Dr Bronwyn Hegarty (Ph.D) Stevan Nikolin (BSc) Natalie Katalinic (BA (Hons)) Research Students Michael Player (BPsych (Hons), Ph.D) Kerrie-Anne Ho (BPsych (Hons), Ph.D) Emily O’Keefe (Medical student, independent learning project) Research Grants NHMRC Project Grant ID 1004152 – Role of neurogenesis in clinical recovery from depression during ECT: Application of a novel in vivo magnetic resonance spectroscopy technology. Dr Michael Valenzuela, Professor Colleen Loo, Dr Jesus Pujol, Professor Petar Djuric, Dr Dennis Velakoulis, Associate Professor Murat Yucel, Professor Mike Dragunow. $505,312 (2011-2013) NARSAD young Investigator Award – Remediation of cognitive dysfunction in euthymic bipolar disorder patients using transcranial direct current stimulation (tDCS), Dr Donel Martin. $60,000 USD (2011-2012) Dementia Collaborative Research Centre grant. Transcranial direct current stimulation (tDCS) to enhance outcomes from computer facilitated cognitive training in patients with mild cognitive impairment (MCI). Principal Investigator Mohan A. Associate Investigators Martin D, Sachdev P, Brodaty H, Loo C, Gates N. $40,000. 2012. Stanley Medical Research Foundation. A Controlled Trial of Transcranial Direct Current Stimulation as a Treatment for Unipolar and Bipolar Depression. 11T-005. Loo C. $681,595 USD (2012-2015) UK MRC/NHS Efficacy and Mechanism Evaluation grant. Ketamine augmentation of electroconvulsive therapy to improve outcomes in depression. Anderson et al. £1,002,385 [Note non UK CIs not permitted. Therefore Prof Colleen Loo is named as an international expert adviser on the grant] (2012) NHMRC Program Grant ID: 1037196.“Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations.” Principal investigator Mitchell P, Schofield P, Parker G, Breakspear M. $7100525. (20132017). NHMRC Project Grant ID 1051423. Electrical Stimulation with a “Random Noise” Pattern: A New Approach for the Treatment of Depression. Principal Investigators Loo C, Mitchell P, Taylor I. $505 380. (2013-2015) UNSW Major Research Equipment & Infrastructure Grant. Near Infrared Spectrosopcy. Loo C, Sachdev P, Mitchell P, Dokos. $ 44,213. 2012. St George Medical Research Foundation Establishment Grant. Does transcranial DirectCurrent Stimulation (tDCS) enhance outcomes from computerised cognitive remediation inpatients with schizophrenia? – A randomised controlled trial in a rehabilitatory setting. Menon A, Loo C, Martin D, Bowman A. $17,000.. 2012. RANZCP New Investigator Grant. Does transcranial DirectCurrent Stimulation (tDCS) enhance outcomes from computerised cognitive remediation inpatients with schizophrenia? – A randomised controlled trial in a rehabilitatory setting. Menon A. $5882. 2012. NSW Institute of Psychiatry Research Fellowship, 0.5 FTE. A study of ketamine as an antidepressant treatment. Lai R. $55,000, 2012. Research Projects in Progress Principal Investigator: Professor Colleen Loo (all studies below) Genetic Factors, Biomarkers and Outcomes of Brain Stimulation An investigation of the effects of trancranial electrical stimulation Open pilot trial of temporal lobe transcranial direct current stimulation (tDCS) for depression Neuroplasticity induced by transcranial direct current stimulation treatment. A pilot study of ketamine as an antidepressant Investigating direct current stimulation as a treatment for depression: A controlled clinical trial A controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression Electrical Stimulation with a “Random Noise” Pattern: A Novel Approach for the Treatment of Depression A comparison of transcranial electrical stimulation methods Anaesthesia in ECT Study A study of transcranial electrical stimulation (TES) as a maintenance treatment for depression. Trial of Bilateral Transcranial Direct Current Stimulation (tDCS) for the treatment of depression Low frequency rTMS: A randomized trial Pfizer Neuroscience Research Grant. A comparative Study of Intravenous, Intramuscular and subcutaneous Administration of Ketamine in Depression. Lai R. $40,000, 2013. Assessment of Suitability for Participation in Research Trials NSW Institute of Psychiatry Research Fellowship, 0.6 FTE. Treating depression in hemodialysis patients: a randomised sham controlled trial of transcranial Direct Current Stimulation (tDCS). Bautovich A. $73 494.30 2013. Enhancing verbal learning and memory using high definition transcranial direct current stimulation (HD-tDCS) RANZCP New Investigator Grant.Treating depression in hemodialysis patients: a randomised sham controlled trial of transcranial Direct Current Stimulation (tDCS). Bautovich A. $6000, 2013. The effect of repeated and intermittent sessions of transcranial electrical stimulation on cortical excitability Remediation of cognitive dysfunction in euthymic bipolar disorder patients using transcranial direct current stimulation (tDCS): A pilot study Transcranial direct current stimulation (tDCS) to enhance outcomes from computer facilitated cognitive training in patients with mild cognitive impairment (MCI) 111 Original Peer-Reviewed Publications 2012 Bai S, Loo C, Dokos S. A computational model of direct brain excitation induced by electroconvulsive therapy: comparison among three conventional electrode placements. Brain Stimulation 2012; 5(3): 408-421. Galvez V, Alonzo A, Martin D, Loo C. Transcranial direct current stimulation (tDCS) treatment protocols. Should stimulus intensity be constant or incremental over multiple sessions? Int J Neuropsychopharmacology 2012; 16(1): 13-21. Loo C, Alonzo A, Martin D, Mitchell P, Galvez V, Sachdev P. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. British Journal of Psychiatry 2012; 200:52-59. Loo C, Katalinic N, Martin D, Schweitzer I. A review of ultrabrief pulse width electroconvulsive therapy. Therapeutic Advances in Chronic Disease 2012; 3(2) 69-83. Smith D, Schweitzer, I, Ingram, N, Loo, C. Successful Ultrabrief ECT for a Mixed Episode of Bipolar Disorder. Australian & New Zealand J Psychiatry, 2012; 46: no. 4 388 doi: 10.1177/0004867411433954 Letter/ case report. Kalu, U, Sexton C, Loo C, Ebmeier K. Transcranial Direct Current Stimulation in the Treatment of Major Depression: A Meta-Analysis. Psychological Medicine 2012; 42(9): 1791-1800. doi:10.1017/S0033291711003059 Chan, H, Alonzo A, Martin D, Player M, Mitchell P, Sachdev P, Loo C. Treatment of major depressive disorder by transcranial Random Noise Stimulation: Case report of a novel treatment. Biological Psychiatry 2012; 72(4): e9-e10 PMID: 22425412. Bai S, Loo C, Dokos S. Effects of electroconvulsive therapy stimulus pulsewidth and amplitude computed with an anatomically-realistic head model. In: Conference Proceedings IEEE Engineering in Medicine and Biology Society, 2012; p. 2559-2562. 2013 Loo C, Garfield J, Katalinic N, Schweitzer I, Hadzi-Pavlovic D. Speed of Response in Ultrabrief and Brief Pulse Width Right Unilateral ECT. Int J Neuropsychopharmacology 2013; 16: 755-761. Loo C. ECT in the 21st Century: Ultrabrief pulse stimulation – a new development in treatment technique. Australian Prescriber 2013; 36(1) 22-23. Perich T., Mitchell, P.B., Loo, C., Hadzi-Pavlovic, D., Roberts, G., Lau, P., Wright, A., Frankland, A. Clinical and demographic features associated with the detection of early warning signs in bipolar disorder, Journal of Affective Disorders 2013; 145(3): 336-340. doi.org/10.1016/j. jad.2012.08.014. Martin D, Alonzo A, Ho, K-A, Player M, Mitchell P, Sachdev P & Loo C. Continuation transcranial direct current stimulation for the prevention of relapse in major depression. Journal of Affective Disorders 2013; 144: 274278. Chan H, Alonzo A, Martin D, Mitchell P, Sachdev P, Loo C. Augmenting transcranial direct current stimulation with D-cycloserine for depression: A pilot study. J ECT 2013; 29(3):196-200. Cupina D, Patil S, Loo C. Chronic catatonic schizophrenia treated successfully with right unilateral ultrabrief pulse electroconvulsive therapy: A case report. J ECT 2013; 29(2); 134-136. Player, M, Taylor J, Alonzo A, Loo C. Paired associative stimulation increases motor cortex excitability more effectively than theta-burst stimulation. Clinical Neurophysiology 2012; 123(11):2220-6. Rae C, Lee V, Ordidge R, Alonzo A, Loo C. Anodal transcranial direct current stimulation increases brain pH and modulates bioenergetics. International J Neuropsychopharmacology, 2013; 16(8); 1695-1706. Loo C & Martin D. Could transcranial direct current stimulation have unexpected additional benefits in the treatment of depressed patients? Expert Review of Neurotherapeutics. 2012: 12 (7): 751-753. Bai S, Loo C, Dokos S. A review of computational models of transcranial electrical stimulation. Critical Reviews in Biomedical Engineering. 2013;41(1):21-35. Loo C, Katalinic N, Garfield J, Sainsbury K, Hadzi-Pavlovic D, MacPherson R. Neuropsychological and mood effects of ketamine in electroconvulsive therapy: A randomised controlled trial. J Affective Disorders 2012; 142(1-3): 233240. Faculty of 1000 Recommended. Chan H, Mitchell P, Loo CK & Harvey S. Treatment resistant depression: Pharmacological approaches. Medical Journal of Australia 2012; 1(Supp 4); 44-47. 112 Alonzo A, Chan G, Martin D, Mitchell P, Loo C. Transcranial Direct Current Stimulation (tDCS) for Depression: Analysis of Response Using a Three-Factor Structure of the Montgomery-Åsberg Depression Rating Scale. J Affective Disorders, 2013; 150(1); 91-95. Katalinic, N, Lai R, Somogyi, A, Mitchell P, Glue P, Loo CK. Ketamine as a new treatment for depression: A review of its efficacy and adverse effects. Australian & New Zealand J Psychiatry, 2013; 47(8); 710-727. Galvez, V, Loo C, Alonzo A, Cerrillo E, Menchon J, Crespo J, Urretavizcaya M. Do benzodiazepines moderate the effectiveness of bitemporal Electroconvulsive Therapy in Major Depression? J Affective Disorders 2013; 150(2):686690. doi: 10.1016/j.jad.2013.03.028). Martin D, Liu R, Alonzo A, Green M, Player M, Sachdev P, Loo C. Can transcranial direct current stimulation enhance outcomes from cognitive training? A randomized controlled trial in healthy participants. Int J Neuropsychopharmacology 2013; 16(9):1927-1936. Player M, Taylor J, Weickert C, Alonzo A, Sachdev P, Martin D, Mitchell P, Loo CK. Neuroplasticity in Depressed Individuals Compared to Healthy Controls. Neuropsychopharmacology 2013; 38(11):2101-2108 Corry J, Green M, Roberts G, Frankland A, Wright A, Lau P, Perich T, Loo C, Breakspear M, Mitchell P. Anxiety, stress and perfectionism in bipolar disorder. J Affective Disorders 2013; 151(3):1016-1024. Martin D, Katalinic N, Ingram A, Schweitzer I, Smith D, Hadzi-Pavlovic D, Loo C. A new early cognitive screening measure to detect cognitive side-effects of electroconvulsive therapy? J Psychiatric Research 2013; 47(12):1967-1974. Presentations at Scientific Meetings and Conferences All presentations listed are by Professor Colleen Loo 2012 - International International Society for ECT and Neurostimulation Annual Meeting.“Transcranial Direct Current Stimulation”. Symposiumpresenter.Philadephia, US. 6 May, 2012. Presentation to Neuroscience Research Unit, University of Manchester, “Transcranial Direct Current Stimulation: A New Treatment for Depression?” 11 May, 2012. 2012 - National NSW Official Visitors Program-Training Day. “Electroconvulsive Therapy”. 9 February, 2012. Sydney RANZCP Invited symposium speaker: tDCS. Hobart, May 2012. Specialist Mental Health Services for Older People Benchmarking Forum, NSW Health. Guest Speaker – presentation on ECT.NSW Mental Health Drug and Alcohol Head Office, Sydney. 5 June, 2012. ECT and Neurostimulation. Barossa Valley, 1 Sept, 2012. Invited main speaker, Queensland Neuropsychiatry Interest Group, “Neurostimulation Forum”. 27th Oct 2012. Brisbane. ECT workshop, Royal Melbourne Hospital, 14 Nov 2012. Session Chair, Health Service Alliance First Annual Scientific Symposium.“Science and Health for Women in 2012”.Royal Hospital for Women, Sydney.15 Nov, 2012. 2013 - International Invited plenary speaker. “RUL ultrabrief ECT: further RCT evidence”. International Society for ECT and Neurostimulation. San Francisco. 19 May 2013. 2013 - National NSW Official Visitors Program-Training Day. “Treatment Approaches in Electroconvulsive Therapy”.1 9 February, 2013. Sydney. Invited speaker, Professorial Grand Rounds, Westmead Hospital. “Brain Stimulation: A New Tool in Psychiatry”. 4 July 2013. Invited speaker, Health-E-Care Hospitals Planning weekend. “New Directions in Research”. 13-14 July 2013. Byron Bay, NSW. Invited Speaker, The Melbourne Clinic. “Multicentre RCT of Ultrabrief pulse ECT”. Melbourne, 24 July 2013. Plenary Speaker “Transcranial Direct Current Stimulation”. Australian Brain Stimulation conference, Melbourne, Australia. 25-26 July, 2013. St George Hospital Grand Rounds. “ Neuroplasticity in health and psychiatric illness”. 5 Sept 2013. Concord Centre for Mental Health. “Application of Brain Stimulation in Psychiatry”. 19 September 2013. Invited speaker, RANZCP Neuropsychiatry and Behavioural Neurology Conference 8 - 9 November 2013. The Melbourne Brain Centre, University of Melbourne. “ECT: A Constantly Evolving Science”. Speaker “Brain Stimulation is Good for You: ECT & tDCS”. UNSW Brain Sciences Colloquium. Black Dog Institute, 25 November 2013. Invited main speaker, Ramsay Healthcare Continuing Education Workshop on “ECT and TMS”, Adelaide Clinic, SA, August, 2012. Invited Speaker, VIC Chief Psychiatrist’s Clinical Practice Forum: ECT. 3 Dec 2014, Melbourne. [Note all Vic psychiatrists were invited to attend a special ½ day forum, convened to discuss ECT policy and practice in the state of Vic. C Loo was the invited speaker and panel discussant, to provide expert input into this forum.] Invited main speaker, SA NeurostimulationRetreat.Talks on Keynote speaker, ASPR, Melbourne 4-6 Dec 2013. 113 Community Engagement Television The Project – Special Report, “Going Global: electroconvulsive therapy”, 12/6/12 “Ketamine” – ABC Catalyst, 25/10/12 tDCS in depression – Channel 9 National News 6pm, 9/2/13. ECT – Insight program. SBS. 24/9/13. Radio Interview-ABC Radio Darwin, on ECT, 19/12/12 Interview about ECT. ABC Radio (WA). 6/3/13. Interview – Radio Australia, on ECT and tDCS, 6/4/13. Print Media “Brainwave is a breakthrough”. St George and Sutherland Shire Leader. 6/3/12 Ketamine Benefits Depression Patients, says Study TopNews 7/6/12 Ketamine ‘could relieve depression’, Ninemsn 7/6/12 and Bulletin Wire, 7/6/12 Ketamine may relieve depression, trials show, Australian Doctor, 7/6/12 Party drug ‘special k’ may help relieve depression, The Australian Also published on Silobreaker, Topix NewKerala News Track India (Web India 123 Yahoo! Lifestyle India, Big News Network, The Times of India India4u, Jagran Post, The Free Library, Hamara News, AndhraNews.net 7/6/12 Depression trial using Ketamine looking for volunteers, MedIndia. Common anesthetic discovered to be providing instant relief to depression sufferers.,TopNews Arab Emirates, 7/06/12 “’Special’ drug set to ease the blues”, Adelaide Advertiser, 8/6/12. “Shock Value” – Sydney Morning Herald, article about ECT. 10/11/12 “Special K eases blues”, MX Brisbane, 7/6/12. Promising Depression Treatment – article about tDCS in depression New York Times 11/2/13. “A quiet revolution”, UNSW Uniken (http://uniken.unsw. edu.au/features/quiet-revolution), 7/6/12. tDCS in depression. The Globe and Mail, Vancouver. Interviewed 14/2/13. “Ketamine could play anti-depressant role”, India Pharma News (http://www.contify.com/story/ketamine-could-playanti-depressant-role-9041055), 9/6/12 “Lite and easy, Nurse Ratched. Electroconvulsive shock therapy not like it used to be” & “Going with the Current” Australian Financial Review. 6/3/13. Brain cells slower to adapt with depression” Sydney Morning Herald. 1/6/13 “Warning over gamer’s headset”. DIY tDCS. Sun Herald. 30/6/13. Web Media New depression treatment ‘safe and effective’, News Medical Electrical stimulation of the brain is a safe treatment for depression The Conversation Safe And Effective New Treatment For Depression MediLexiton 9/3/12 ’ Special K’ could relieve depression Daily Telegraph UNSW Newsroom Virtual Medical Centre Also published on Sky News, Courier Mail, Medical Xpress Herald Sun, All Voices, News.com.au, Interceder, Bigpond News, Perth Now, Adelaide Now, Arizona Health between 6/6/12 7/6/12 114 Party drug treats depression, Sydney Morning Herald, Also published in Warren Advocate Casey Weekly), Hobsons Bay Weekly 19/6/12. Australian researchers test speedy depression drug, Psychiatry Update 22/6/12 Special K for Depression Renews Hope in Hallucinogens, Bloomberg Also published in The Frostproof News The Lake Wales News, The Polk County Democrat, The Fort Meade Leader 08/7/12-10/7/12 Special K: ketamine’s road from tranquiliser to possible antidepressant, The Conversation 13/12/12 Depressed brains are less plastic. ABC Science. 28/5/13 WOMEN’S AND CHILDREN’S HEALTH Urogynaecology > 116 Women’s Health > 119 > Department of Urogynaecology Head of Department Professor KH Moore MBBS MD FRCOG FRANZCOG CU Senior Medical Dr E Karantanis MBBS FRANZCOG MD CU Junior Medical Dr N Te West Dr Z Chen Research Staff Dr Ying Chen – Laboratory Scientist Wendy Allen – Nurse Continence Advisor Katrina Parkin – Nurse Continence Advisor Wendy Hayes – Physiotherapist Research Grants NHMRC – 2009-2012 Principal investigators – R. Chess-Williams, E. Burcher, KH. Moore, Non-neuronal ATP: Regulation of release and Action in the bladder Total awarded; years funded - $ 420,000; 2009-2012. UNSW Faculty of Medicine 2012 – “Silver Star” Grant in recognition of high score non-funded NHMRC Grant application. Principal investigators – Professor Kate Moore Total awarded $20,000. Thera Vida Randomised Control Trial 2011-2012. Principal investigators – Professor Kate Moore Total awarded $30,000. Research Projects in Progress Prospective Multicentre observational trial of vaginal oestriol cream for women with stress incontinence, KH Moore Sydney, JP Roovers Amsterdam, S Jeffries, Capetown Prospective observational study of Patient Motivation Questionnaire in relation to pelvic floor physiotherapy compliance, KH Moore, E Karantanis W Hayes, K Parkin, W Allen. Randomised placebo controlled trial of antibiotics for patients with refractory detrusor overactivity, KH Moore, K 116 Mansfield (University of Wollongong), Y Cheng, V Gebski (University of Sydney) Development of novel techniques for identification of intracellular bacteria in human urothelial cells Y Cheng, K Mansfield (University of Wollongong, KH Moore M Schembri (University of Queensland). Original Peer-Reviewed Publications 2012 Shahab RB, Sarma S, Moore KH, Kuteesa WMA, Cebola M, Walsh CA, Wang YA, Karantanis E. Randomized Controlled Trial of Cough Test versus no Cough Test in the Tension-Free Vaginal Tape Procedure effect upon Voiding Dysfunction and 12 month Efficacy. Int Urogyn J, 2012; 23:435-441. Karantanis E, Painter V, Moore KH. Does patient activity level affect 24-hour pad test results in stress-incontinent women? Neurol & Urodyn 2012; 31: 143-147 . Ho M, Kuteesa W, Short A, Eastwood A, Moore KH. Incontinence after childbirth: Long-term analysis of direct costs of conservative and surgical therapy. Aust NZ Cont J 2012; 18: 10-19 Hannan TJ, Totsiks M, Mansfield KJ, Moore KH, Schembri MA, Hultgren SJ. Host-Pathogen Checkpoints and Population Bottlenecks in Persistent and Intracellular Uropathogenic E Coli Urinary Tract Infection. FEMS Microbiol Rev. 2012 36:616-48. 2013 Walsh CA, Cheng Y, Mansfield KJ, Parkin K, Mukerjee C, Moore KH. Decreased intravesical ATP in patients with refractory detrusor overactivity and bacteriuria. J Urol 2013; 189: 1383-7. Cheng Y, Mansfield KJ, Allen W, Millard RJ, Burcher E, Moore KH. Correlation between Cystometric volumes, ATP release, and pH in women with overactive bladder versus controls. Neurourol Urodyn. 2013;32:969-73 Mansfield KJ, Cowan T, Cheng Y, Allen W, Moore KH. Predicting refractory Detrusor overactivity: Are there any clues at Diagnosis? EMJ Urology 2013; 1: 87-91. Moore KH, Allen W, Woodman J, Bushati A, Burcher E. Response to resiniferatoxin in women with refractory detrusor overactivity: Role of bacterial cystitis. Aust NZ Cont J 2013; 19: 66-73. Wong V, Kim S, Moore KH. Why are some women with pelvic floor dysfunction unable to contract their pelvic floor muscles? ANZJOG 2013; Oct 1. doi: 10.1111/ajo.12133. Hagen S, Stark D, Glazener C, Dickson S, Barry S, Elders A, Frawley H, Galea MP, Logan J, McDonald A, McPherson G, Moore KH, Norrie J, Walker A, Wilson D, Individualised Pelvic Floor muscle training in women with pelvic organ prolapse: a multicentre randomised controlled trial. doi: 10.1016/SO140-6736 (13) 61977-7 Epub 27th Nov 2013 Lancet. Davidson JE, Moore KH. Is Pelvic Floor Muscle Training as Effective for Urinary Incontinence in the Elderly as Compared to the General Population? A&NZ Cont J 2013: 19:18-25. Deepak I, Sundac L, Benjamin W, Moore KH, Ulett G. Asymptomatic bacteriuria: prevalence rates of casual microbes, etiology of infection in different patient populations, and recent advances in molecular detection. FEMS Microbiol Lett. 2013; 346: 1-10. Other Published Material Book Chapter Moore KH, Subak L, Wagner TH, De Wachter S, Dudding T. Economics of Urinary & Faecal Incontinence, and Prolapse. Report of World Health Organisation, Editors: Abrahams P, Cardozo L, Koury S, Wein A. 2012; 1829-1861 Health Publications Ltd., Plymouth. Text Book Moore, KH. Urogynecology in Evidence Based Clinical Practice. Second Edition. Textbook. Editor Moore, KH. 2012. ISBN: 9781447142904. Invited to write the second edition of this monograph by Springer-Verlag, London. Presentations at Scientific Meetings and Conferences 2012 International Mansfield KJ, Cheng Y, Moore KH. Treatment of urothelial cells with lipopolysacchardie from enteropathogenic E. Coli reduces stretch induced ATP release. Journal of Urology 2012; 187: e368-369, American Urological Assosciation, Chicago. Cheng Y, Mansfield KJ, Burcher E, Moore KH. ATP release during bladder filling in women with bladder oversensitivity. American Urological Assosciation, Chicago Journal of Urology 2012; 187: e934-e935. Mansfield KJ, Moore KH, Cheng Y, Schembri M. Effect of Escherichia coli lipopolysaccharide on stretch-induced ATP release from cultured urothelial cells. Beijing ICS meeting Neurourol & Urodyn 2012; 31: 1024-1025. Bahadory F, Markus I, Cheng Y, Moore KH, Liu L, Burcher E. Gene expression of purinergic, muscarinic and tachykinin receptors in porcine bladder: comparison in fresh tissue and cultured urothelium, myofibroblast and detrusor muscle cells. 2012 Beijing; Proc. ICS meeting, Poster. Cheng Y, Mansfield KJ, Schembri M, Moore KH. Novel Fluorescent staining methods for detection of adherent with Intracellular Bacteria in urothelial cells from patients with refractory urgency. International Urogynaecology Association ASM (IUGA) Brisbane – Oral Presentation. Int. Urogyn J, 23; S117-S118. Hayes W, O’Toole J, Thakkar A, Karantanis E, Moore KH. Randomized Controlled Trial: Extracorporeal Magnetic Innervation versus Pelvic Floor Muscle Training in Women with Stress Urinary Incontinence. 2012 IUGA Brisbane – Oral Presentation. Int. Urogyn, J, 23; S213-S214. 2012 National Bahadory F, Markus I, Cheng Y, Moore KH, Liu L, Burcher E. Gene expression of neurochemical receptors in porcine bladder and cultured cells: comparison in urothelium, myofibroblasts and detrusor. St George Medical Research Foundation. Oct 2012, Prize for Best Poster. 2013 International Cheng Y, Mansfield KJ, Mukerjee C, Allen W, Schembri MA, Moore KH. Development of Novel Techniques for Investigation of Intracellular Bacteria in Urothelial Cells from Patients with Incontinence. International Urogynaecological Association Meeting Dublin. Int. Urogyn J, 2013; 24: 123 – 124. 117 Chen Z, Wong V, Moore KH. Nine year subjective and Objective follow up of the Ultra-lateral Anterior Vaginal Repair for Cystocoele. International Urogynaecological Association Meeting, Dublin. Int. Urogyn J, 2013; 24: 59– 61. Wong V, Guzman RA, Rojas K, Shek K, Chou D, Moore KH, Dietz P. Predictors of prolapse recurrence following laparoscopic sacrocolpopexy. International Urogynaecological Association Meeting Dublin. Int. Urogyn J, 2013; 24: 64 – 65. Cheng Y, Moore KH. Comparison of Nitric Oxide release during urodynamic test between detrusor overactive women and controls. Neurourol & Urodyn 2013; 32: 74648 International Continence Society Barcelona. Bahadory F, Burcher E, Moore KH, Liu L. The gene expression of target proteins and receptors for Botox in porcine bladder, and down regulation of SNAP-25 in cultured cells, International Continence Society. August, Barcelona, poster. Wong V, Rodirgo Guznian R, Sheu KL, Chow D, Moore KH, Dietz P. Cystocele recurrence following laparoscopic sacrocolpopexy: How low does the mesh go? Neurourol & Urodyn 2013; 32: 705-707 International Continence Society Barcelona. Wong V, Kim S, Moore KH. How common is levator muscle defect in women with acontractile pelvic floor. International Continence Society, August, Barcelona. Parkin K, Walsh D, Hayes W, Wong V Karantanis E, Moore KH. Does the Incontinence treatment motivation questionnaire (ITMQ) predict response to pelvic floor physiotherapy for Stress Urinary Incontinence? International Continence Society August, Barcelona, poster. Leek H, Reus A, Stephenson Z, Karantanis E, Moore K. Clean Intermittent Self-Catheterisation: A randomised Control Crossover Trial of single-use versus multiple re-use of non-coated catheters; is cystitis rate altered? Neurourol & Urodyn 2013; 32: 759-760 International Continence Society Barcelona. Cowan T, Mansfield KJ, Cheng Y, Allen W, Moore K. Does Intravesical ATP or Recurrent Bacterial Cystitis predict response to antimuscarinics in Detrusor Overactivity. 118 International Continence Society August, Barcelona, poster. Cheng Y, Mansfield KJ, Allen W, Millard R, Burcher E, Moore K. Correlation Between Cystometic Volumes, ATP Release and pH in Women with Overactive Bladder Versus Controls Neurourol & Urodyn 2013; 32: 969-973 International Continence Society Barcelona. 2013 National Chen Z, Wong V, Wang A, Moore KH. Nine year subjective and objective follow up of the Ultra-Lateral Anterior Vaginal Repair for Cystocoele. UGSA meeting Garvan Institute of Medical Research, March. Leek H, Reus A, Stephenson Z, Karantanis E, Moore KH. Clean Intermittent Self-Catheterisation: An RCT of singleuse versus multiple re-use of Catheters – UTI Risk and Cost Implications. UGSA meeting Garvan Institute of Medical Research, March. Community Engagement Professor Kate Moore Professor Kate Moore is the inaugural Chairman of the Urogynaecological Society of Australasia, a society of continence clinicians, which aims to promote research, training and education about pelvic floor dysfunction across Australia and New Zealand. The Society holds an Annual Scientific meeting, attended by approximately 200 gynaecologists, physio therapists and nurse continence advisors, as well as a workshop attached to the RANZCOG annual meeting and also holds regional meeting (e.g. Mackay, Cairns). The society administers the Australian Pelvic Floor Surgery Database, which enables monitoring of surgical outcomes, including the use of polypropylene mesh for prolapse surgery. > Department of Women’s Health Head of Department Professor Michael Chapman – MBBS, MD, FRCOG, FRANZCOG, CREI Professor of Obstetrics & Gynaecology Co-Director of Women’s & Children’s Health St George Hospital, Head of School - Women’s & Children’s Health UNSW Senior Medical Professor Kate Moore – Professor of Obstetrics & Gynaecology UNSW, Urogynaecologist. MB BS Syd, MD Liv, FRCOG, FRANZCOG, CU A/Prof Greg Davis - Senior Staff Specialist Obstetrician & Gynaecologist, Conjoint A/Prof UNSW/Adj Prof UTS. MBChB, MD, FRCOG, FRANZCOG A/Prof Gavin Sacks – Staff Specialist Obstetrician, Fertility Specialist, Conjoint A/Prof UNSW. MA (Cantab) BM BCh (Ox) PhD (Ox) MRCOG FRANZCOG CCSST (UK) Dr John Breen – Staff Specialist Obstetrician & Gynaecologist, Conjoint Lecturer UNSW. BSc Hons, MBChB, MRCOG, FRANZCOG Dr Greg Cario – VMO Obstetrics & Gynaecology, Laparoscopic Surgeon, Conjoint Senior Lecturer UNSW. MB, BS (Syd) Hons, FRANZCOG, FRCOG Dr Danny Chou – VMO Gynaecology, Laparoscopic Surgeon, Conjoint Lecturer UNSW. MBBS MRCOG FRANZCOG Dr Ludmilla Collins – VMO Obstetrics & Gynaecology. MBBS, FRANZCOG Dr Amanda Henry – Consultant Obstetrician, Lecturer UNSW. MA Public Health, FRANZCOG, B.Med. (Hons) ,B.Med.Sci (Hons), DDU(O&G) Dr Emmanuel Karantanis - Staff Specialist Obstetrician & Gynaecologist, Conjoint Senior Lecturer UNSW. BSc(Med), MBBS(Hons), FRANZCOG, PhD, CU Dr Gavin Kemball – VMO Obstetrics & Gynaecology, Fertility Specialist, Conjoint Lecturer UNSW. MBBS, MRCOG, FRANZCOG, BSc, MSc Dr Chandra Krishnan – Staff Specialist Obstetrician, Fertility Specialist, Conjoint Lecturer UNSW. MB BS (Syd) FRANZCOG Dr Trent Miller – Staff Specialist Obstetrician & Gynaecologist, Training Supervisor St George Hospital, Conjoint Lecturer UNSW. MBBS(Hons), FRANZCOG Dr Michael O’Connor AM – VMO Obstetrics & Gynaecology, Conjoint Senior Lecturer UNSW. MD. BS (Hons), MHL (Syd), DCH.DDU.MRCOG (Gold Medal). FRCOG. FRANZCOG.FACLM. Dr James Opperman – VMO Obstetrics & Gynaecology. MBBS (Syd. Hons.), FRANZCOG Dr David Rosen – VMO Gynaecology, Laparoscopic Surgeon. MBBS FRANZCOG Dr Steven Thou – Staff Specialist Obstetrician & Gynaecologist, Conjoint Lecturer UNSW.BSc (Med) (Hons), MBBS (Hons), FRANZCOG Dr Queeny Wong – VMO Obstetrics. MBBS, FRANZCOG Dr Andrew Zuschmann - Staff Specialist Obstetrician & Gynaecologist, Fertility Specialist, Conjoint Lecturer UNSW. BSc(Med) MBBS MReprodMed (UNSW) FRANZCOG Junior Medical Dr Trupti Kanade – Fellow in Laparoscopic Surgery Dr Shadi Khashaba – Fellow in Reproductive Endocrinology & Infertility Dr Joanne McKenna –Fellow in Laparoscopic Surgery Dr Brian Tsai – Fellow in Laparoscopic Surgery Dr Christos Venetis – Fellow in Reproductive Endocrinology & Infertility Senior Midwifery Research Fellow Professor Caroline Homer PhD, RN, RM (Professor of Midwifery, UTS) Research Midwife Mrs Lynne Roberts MMid MHSc Research Grants NHMRC Project Grant: De Lacey S; Chapman MG; Ratcliffe J. Acupuncture to improve live birth rates for women undergoing IVF: a randomised controlled trial. Total Grant: $634,969 (2011-15). ARC Discovery Grant: Foureur M, Homer CSE, Fenwick J, 119 Davis D, Sorensen R, Forbes I. Theorising the relationship between birth unit design and the communication patterns of labouring women and their maternity care providers. 2012: $91,340; 2013: $86,140. NHMRC Project Grant: Homer CSE, Ellwood D, Oats J, Foureur MJ, Sibbritt D, McLachlan H, Forster D, Dahlen H. Birthplace in Australia: A prospective cohort study. $790,175 (2012-2015). NHMRC Project Grant: Homer CSE, Foureur MJ, Davis D, Adams J, Porteous A. Does Continuity Of Midwifery Care Increase Vaginal Birth After Caesarean (VBAC): A Randomised Controlled Trial. $257,550 (2012-2015). NHMRC Project Grant:– Kildea S, Martensson L, Webster J, Homer CSE, Stapleton H, Beckmann M, Gao Y, Gibbons K. Impact on Caesarean Rates following Injections of Sterile Water (ICARIS) – A randomised controlled trial. $456,760 (2012-2014). St George and Sutherland Medical Research Foundation. Clinical Researcher Award for 2013. Henry A, $20,000, (2013). Australasian Society of Ultrasound in Medicine Research Grant Fetal cardiovascular evaluation after maternal betamethasone Vs dexamethasone administration. Welsh A, Henry A, Shand A. $15,000 (2012). UNSW Medicine Major Research Equipment and Infrastructure Initiative. Henry A, Welsh A, Abbott J, Nesbitt-Hawes E, Schindler, T. $100,000, (2013). Research Projects in Progress Fetal cardiovascular response to maternal corticosteroid administration: a comparison of dexamethasone versus betamethasone” (Short title: SUPER-A*STEROID). Henry A, Welsh AW, Shand A, Crowther C, Davis G, Palmer A. Fetal Doppler and the Tei index for evaluation of normal and pathological pregnancy. Henry A, Welsh AW. Third trimester ultrasound: an audit of current practices at St George Hospital. Henry A, King K, Foo J. Midwifery-led intervention group for pregnant women of high body mass index: engagement with and outcomes of SSWInG. Henry A, Chwah S, Reilly A, Hall B, O’Sullivan A. Triggers for delivery in pre-eclampsia: a retrospective cohort study. Henry A, Varnier N, Brown M, Pettit F, Mangos G, Davis G. Trajectory of platelets in pregnancy. Henry A, Duong C, Kidson-Gerber G. Postpartum Physiology, Psychology and Paediatric (P4) follow up study. Principal Investigator Davis G. 120 Department of Women’s Health is a Collaborating Centre for the following multicentre randomised controlled trials: Australasian antenatal Study To Evaluate the Role Of Intramuscular Dexamethasone versus betamethasone (ASTEROID) Study. Principal Investigator: Prof Caroline Crowther. University of Adelaide and Women’s and Children’s Hospital, Adelaide. Site Investigator SGH A/Prof Greg Davis. Candida in Pregnancy study (CiPS). Principal Investigator: Prof Jonathon Morris. University of Sydney at Royal North Shore Hospital. Site Investigator SGH: A/Prof Greg Davis. MAgnesium sulphate at 30 to 34 weeks’ GEstational age: Neuroprotection TriAl (MAGENTA). Principal Investigator: Prof Caroline Crowther. University of Adelaide and Women’s and Children’s Hospital, Adelaide. Site Investigator SGH: A/Prof Greg Davis. Preterm Prelabour Rupture Of Membranes close to Term (PPROMT) Trial. Principal Investigator: Prof Jonathan Morris. Royal North Shore Hospital, Sydney. Site Investigator SGH: A/Prof Greg Davis. PROGesterone after previous preterm birth for the prevention of neonatal RESpiratory distress Syndrome (PROGRESS) Trial. Principal Investigator: Prof Caroline Crowther. University of Adelaide and Women’s and Children’s Hospital, Adelaide. Site Investigator SGH: A/ Prof Greg Davis. Triggers for pre eclampsia. Principal Investigator: Dr Jane Ford. University of Sydney at Royal North Shore Hospital. Site Investigator SGH: A/Prof Greg Davis. Original Peer-Reviewed Publications 2012 Amari E, Fowler C, Homer CSE. Bed sharing with infants in a time of SIDS awareness. Neonatal Paed Child Health Nurs 2012;15(2): 3-7. Brown MA, Roberts LM, Mackenzie C, Mangos GJ, Davis GK. A Prospective Randomised study of Automated versus Mercury blood pressure recordings in hypertensive pregnancy (PRAM study). Hypertens Preg. 2012; 31:107119. Budden A, Henry A, Heatley E. Oxytocin infusion regimens for induction of labour (protocol). Cochrane Library, Issue 3, 2012. Catling-Paull C, Foureur MJ, Homer CSE on behalf of the members of the Publicly-funded Homebirth Consortium. Publicly-funded homebirth models in Australia. Women Birth 2012; 25: 152-158. Dahlen HG, Homer CSE. Web-based News Reports on Midwives Compared with Obstetricians: A Prospective Analysis. Birth. Article first published online: 9 Jan 2012. DOI: 10.1111/j.1523-536X.2011.00512.x Dahlen, H.G., Homer, CSE. Motherbirth or childbirth? A prospective analysis of vaginal birth after caesarean blogs. Midwifery 2012;29: 167-173. Henry A, Clements S, Kingston A, Abbott J. In search of work/life balance: trainee perspectives on part-time obstetrics and gynaecology specialist training. BMC Res Notes 2012; 5:19 doi:10.1186/1756-0500-5-19 Hawkins T, Roberts J, Mangos G, Davis G, Roberts L, Brown M. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: A retrospective cohort study. BJOG.2012; 119:484-492. Hawkins TL, Brown MA, Mangos GJ, Davis GK. Transient gestational hypertension: Not always a benign event. Preg Hypertens: Int J Women’s Cardiovasc Health 2012; 2(1): 22-27. Homer CSE, Catling-Paull C. Safe timing for an urgent caesarean section: What is the evidence to guide policy? Aust Health Rev 2012; 36 (3): 277-281. Homer CSE, Allende T, Pekin F, Caplice S, Catling-Paull C, Foureur MJ. It’s more than just having a baby. Women’s experiences of a maternity service for Aboriginal and Torres Strait Islander families. Midwifery 2012;28(4): E449-E455. Homer CSE, Griffith M, Brodie PM, Kildea S, Curtin A, Ellwood D. Developing a core competency model and educational framework for primary maternity services: a national consensus approach. Women Birth 2012; 25(3): 122-127. Homer CSE, Lees T, Stowers P, Aiavao F, Sheehy A, Barclay LM. Traditional birth attendants in Samoa: Integration with the formal health system. Int J Childbirth. 2012; 2(1): 5-11. Ith P, Dawson A, Homer CSE. (2012) Quality of Maternity Care Practices of Skilled Birth Attendants in Cambodia. Int J Evid Based Healthc 10: 60–67. Koch J; Rowan K; Rombauts L; Yazdani A; Chapman M; Johnson N. Endometriosis and Infertility - A consensus statement from ACCEPT (Australasian CREI Consensus Expert Panel on Trial evidence) Aust N Z J Obstet Gynaecol 2012; 52: 513 – 522. Moore KH, Shahab RB, Walsh CA, Kuteesa WM, Sarma S, Cebola M, Allen W, Wang YA, Karantanis E. Randomized controlled trial of cough test versus no cough test in the tension-free vaginal tape procedure: effect upon voiding dysfunction and 12-month efficacy. Int Urogynecol J. 2012; 23(4):435-41. Painter V, Karantanis E, Moore KH. Does patient activity level affect 24-hr pad test results in stress-incontinent women? Neurourol Urodyn. 2012;31(1):143-7 Smith RM, Brodie PM, Homer CSE. (2012) Reviewing and reflecting on practice: the midwives experiences of credentialing. Women Birth 2012; 25: 159-165. Roth H, Homer CSE, Fenwick J.) “Bouncing back”: How Australia’s leading women’s magazines portray the postpartum ‘body’. Women Birth 2012; 25:128-128. Sacks G; Fay L; Chapman M; Smith S; Yang Y; Gowen E. Detailed Analysis of Peripheral Blood Natural Killer Cells in Women with Repeated IVF Failure. Am J Reprod Immunol. 2012; 67: 434 – 442. Shahheidari M, Homer CSE. Impact of the design of Neonatal Intensive Care Units on neonates, staff, and families: A systematic literature review. J Perinat Neonat Nurs 2012; 26(3):260-6. Smith CA; de Lacey S; Chapman M; Ratcliffe J; Norman RJ; Johnson N; Sacks G; Lyttleton J; Boothroyd C. Acupuncture to improve live birth rates for women undergoing in vitro fertilization: A protocol for a randomized controlled trial. Trials 2012, 13:60 Smith, R, Gray, J, Raymond, J, Catling-Paull, C, Homer, CSE. Integrating simulation into a theoretical subject for midwifery students. Clin Simul Nurs. 2012; 8(9): e451-e457. Vaughan G, Pollock W, Peek M, Knight M, Ellwood D, Homer CSE, Jackson-Pulver L, McLintock C, Ho T, Sullivan EA. Ethical issues: the multi-centre low-risk ethics/ governance review process and AMOSS. Aust N Z J Obstet Gynaecol 2012; 52:195–203. Wheeler J, Davis D, Brodie PM, Fry M, Homer CSE. Is Asian ethnicity an independent risk factor for severe perineal trauma in childbirth? A systematic review of the literature. Women Birth 2012; 25(3):107-13. 2013 Catling-Paull C, Coddington R, Foureur M, Homer CSE. Publicly-funded homebirth in Australia: A review of maternal and neonatal outcomes for the last 6 years. Med J Aust 2013;198(11): 616-620. Chambers GM; Wang YA; Hoang VP; Sullivan EA; Chapman MG; Ledger W; Abdalla HI. What can we learn from a decade of promoting safe embryo transfer practices? A comparative analysis of policies and outcomes in the UK and Australia, 2001-2010. Hum Reprod 2013; 28: 1679 - 1686 Chapman MG; Sacks G. Recurrent miscarriage: Investigating the potential causes. Med Today. 2013. 13: 61 - 65 121 Dawson A, Brodie PM, Copeland F, Rumsey M, Homer CSE. Collaborative approaches towards building midwifery capacity in low income countries: A review of experiences. Midwifery; Epub 2013 Jul 1, doi: 10.1016/j. midw.2013.05.009. Homer CSE, Catling CJ, Scarf VL, Sibbritt D. The profile of women who consult midwives in Australia. Women Birth 2013;26: 240-245. Ith P, Dawson A, Homer CSE. Women’s perspective of maternity care in Cambodia. Women Birth 2013;26: 71–75. Dawson, AJ, Buchan J, Duffield, C, Homer CSE, Wijewardena, K. Task shifting and sharing in maternal and reproductive health in low-income countries: A narrative synthesis of current evidence. Health Policy Plan 2013; doi: 10.1093/heapol/czt026. Ith P, Dawson A, Whelan A, Homer CSE. Practices of skilled birth attendants during labour, birth and the immediate postpartum period in Cambodia. Midwifery 2013;29(4): 300-7. Dawson A; Homer C. Managing the International Humanitarian and Development Health Workforce: A review of experiences and needs. Asia Pac J Health Manage. 2013. 8(1): 14-23. Lee N, Mårtensson LB, Homer C, Webster J, Gibbons K, Stapleton H, Dos Santos N, Beckmann M, Gao Y, Kildea S. Impact on Caesarean section rates following injections of sterile water (ICARIS): a multicentre randomised controlled trial. BMC Preg Childbirth 2013, 13:105. Dawson A, Homer CSE. How does the mining industry contribute to sexual and reproductive health in developing countries. J Clin Nurs 2013; 22 (23-24): 3597–3609. Farrokh-Eslamlou H, Eslamli M, Aghlmand S, Homer CSE. The impact of World Health Organization’s DecisionMaking Tool for Family Planning Clients and Providers on the Quality of Family Planning Services in Iran. J Fam Plan Reprod Health Care 2013;0:1–7. Gray JE, Leap N, Sheehy A. Students’ perceptions of the follow-through experience in three year Bachelor of Midwifery Programs in Australia. Midwifery 2013;29, 400–406. Halliday L, Sullivan E, Peek M, Ellwood D, Homer CSE, Knight M, McLintock C, Jackson-Pulver L. The Australasian Maternity Outcomes Surveillance System (AMOSS): An evaluation of stakeholder engagement, usefulness, simplicity, acceptability, data quality and stability. Aust N Z J Obstet Gynaecol 2013;53(2):152-7. Hammond A, Foureur M, Homer CSE, Davis D. Space, place and the midwife: Exploring the relationship between the birth environment, neurobiology and midwifery practice. Women Birth 2013; 26(4): 277-281. Henry A, Madan A, Reid R, Tracy SK, Austin K, Welsh AW, Challis D. Outpatient Foley catheter versus inpatient prostaglandin E2 gel for induction of labour: a randomised trial. BMC Preg Childbirth 2013, 13:25. Henry A, Shand A, Welsh AW. The short term fetal cardiovascular effects of corticosteroids used in obstetrics. Austral J Ultrasound Med 2013; 16: 128-134. Homer CSE, Besley K, Bell J, Davis D, Adams J, Porteous A, Foureur M. Does continuity of care impact decision making in the next birth after a caesarean section (VBAC)? A randomised controlled trial [Trial Protocol]. BMC Preg Childbirth 2013,13:140. 122 Listijono DR; Chapman MG; Boylan T; Cooke S; Kilani S. An analysis of the impact of embryo transfer difficulty on live birth rates, using a standardised grading system. Hum Fertil (Camb). 2013; 16(3): 211-4. McLindon LA; Beckmann M; Flenady V; McIntyre HD; Chapman M. Women’s views of a fertility awareness and hormonal support approach to subfertility. Hum Fertil (Camb). 2013;16:252-7. Raymond J, Smith RM, Gray JE, Homer CSE. Learning through authentic assessment: an evaluation of a new development in the undergraduate midwifery curriculum. Nurse Educ Pract 2013;13(5): 471–476. Richter J, Henry A, Ryan G, DeKonninck P, Lewi L, Deprest J. Amniopatch procedure after previable iatrogenic rupture of membranes: a two centre review. Prenat Diagn 2013; 33(4): 391-6. Russell P, Sacks G, Tremellen K, Gee A The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure: Further observations and reference ranges. Pathology. 2013; 45:393-401 Sanderson J, Wu L, Mahajan A, Meriki N, Henry A, Welsh A. Selection of the Sub-Noise Gain level for acquisition of VOCAL datasets: a reliability study. Ultrasound Med Biol 2013; DOI: 10.1016/j.ultrasmedbio.2013.09.004. Shaban I, Hatamleh, R, Homer CSE. Evaluating the Experience of Jordanian Women with Maternity Care Services. Health Care Women Int 2013;34(6):499-512. Sheehy A, Davis D, Homer CSE. Assisting women to make informed choices about screening for Group B Streptococcus in pregnancy: A critical review of the evidence Women Birth 2013;26: 152–157. Teate A, Leap N, Homer CSE. Midwives’ experiences of becoming CenteringPregnancy facilitators: A pilot study in Sydney, Australia. Women Birth 2013; 26(1): e31–e36. Tracy SK, Hartz DL, Tracy MB, Kildea S, Allen Y, Forti A, Hall B, Lainchbury A, Stapleton H, Beckmann M, Bisits A; Homer CSE, Foureur M, White J, Welsh A. Caseload midwifery care for women of all risk compared to standard hospital care: a randomized controlled trial. (Midwives @ New Group practice Options: M@NGO trial.) Lancet 2013;382 (9906): 1723 – 1732 Vallely, LM Homiehombo P, Kelly AM, Vallely A, Homer CSE, Whittaker, A. Exploring women’s perspectives of access to care during pregnancy and childbirth: A qualitative study from rural Papua New Guinea. Midwifery 2013;29(10):1222-9. Other Published Material Atchan M, Homer CSE. (2013) Routine care of postpartum women. In J. Abbott, L Bowyer, M Finn [Eds]. Obstetrics and Gynaecology: An Evidence-Based Guide. Elsevier Australia [219-230]. Henry A. Chapter 13. Infections in pregnancy. In: Abbott J, Bowyer L, Finn M (eds). Ot. Elsevier Australia 2013. Presentations at Scientific Meetings and Conferences 2012 - International Chapman MG. Corifollitropin Alfa – IVF Australia’s First 100 Cases FSA Meeting, Auckland, New Zealand, 2012 Chapman MG. Invited Speaker: Selection of the best oocyte. Midwestern Reproductive Symposium, Chicago, IL, USA, 2012 Homer CSE. (2012). Unravelling evidence based practice in policy and reality – local, national, and international stories from the field. Invited keynote speaker at Celebrating Success: Turning best practice into common practice in maternal and infant health and care, University of York, UK. Homer CSE, Lees T, Stowers P, Aiavao F, Sheehy A, Barclay LM. (2012) Traditional birth attendants in Samoa: Integration with the formal health system. ICM Asia Pacific Conference, Vietnam. Meriki N, Henry A, Welsh AW. Development of normal gestational ranges for the right myocardial performance index in the Australian population with 3 alternative caliper placements. Ultrasound in Obstetrics and Gynaecology 2012; 40 (Suppl 1): 137. Welsh AW, Meriki N, Henry A. The ‘Delta-MPI’: a new measure for unilateral fetal myocardial strain and its normal gestational range. Ultrasound in Obstetrics and Gynaecology 2012; 40 (Suppl 1): 138 Davis GK, Roberts LM, Mangos G, Brown MA. The UM101 mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? Biennial Scientific Meeting ISSHP 2012, Geneva (Poster) 2012 - National Chen L, Gardiner A, Austin K, Kidson-Gerber G, Henry A. Iron sucrose infusion in pregnancy. RANZCOG Annual Scientific Meeting, Canberra, 2012. Davis GK, Roberts LM, Mangos G, Brown MA. The UM101 mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? Society of Obstetric Medicine of Australia and New Zealand. Annual Scientific Meeting. Sydney 2012. Dilgir S, Parkin K, Patton V, Lubowski D, Karantanis E. Predictive factors for Obstetric Anal Sphincter Injury. IUGA ASM Brisbane 2012. Everitt L, Homer C, Fenwick J. Midwives Experience of Working with Community Services during Assumption of Care of Newborns. Breathing New Life into Maternity Care: Working together: balancing risk in maternity care. Melbourne 2012. Everitt L, Lock K, Fenwick J, Homer C. Breastfeeding and assumption of care of newborns. The Inaugural Lactation Consultants of Australia and New Zealand (LCANZ) Conference. Sydney 2012. Everitt, L. Learning to play the hard course: Midwives role in assumption of care of newborns. Australian College Midwives – NSW Branch Inc. Annual State Conference, Playing the Course: A Round in Midwifery. Wyong 2012. Hayes W, O’Toole J,Thakkar A, Moore K, Karantanis E. Randomised Control Trial of Electromagnetic Chair versus PElvic Floor Physiotherapy for women with stress urinary incontinence. IUGA ASM 2012 Brisbane. Homer CSE, Foureur M. The Potential Epigenetic Impact of Peripartum Events and Long-term Cardiovascular Health. Invited speaker at the Royal Hospital for Women Annual Symposium: Celebrating 100 years of Antenatal Care, Sydney 2012. Homer CSE, Sandall J, Nicholl M, Redshaw M. Designing a woman centered maternity service – balancing safety, cost, geography and reality. Invited full day workshop at Breathing New Life into Maternity Care, 4th Biennial Conference. Melbourne 2012. Homer CSE. The Homebirth consortium study. Place of Birth and Models of Care Conference. University of Western Sydney, 2012. Roberts LM. What’s new in recording blood pressure in pregnancy? St George Hospital Midwifery Seminar: Working Together. Sydney 2012. 123 Chapman MG. Polarised light microscopy in oocyte selection RANZCOG CREI Annual Meeting, Sydney, 2012 and Gynaecology RANZCOG Annual Scientific Meeting, Sydney, 2013 (e-poster). Chapman MG. Current Concepts on assisted reproduction and fertility preservation ESA-SRB Meeting, Gold Coast, 2012 Chapman MG. Invited Speaker: Preparing for retirement. RANZCOG ASM, Sydney, 2013. 2013 - International Henry A, Welsh AW. Monitoring cholestasis of pregnancy using the fetal modified myocardial performance index (mod-MPI). 23rd World Congress on Ultrasound in Obstetrics and Gynecology, Sydney, 2013. Henry A, Meriki N, Mahajan A, Sanderson J, Wu L, Welsh AW. Delta-MPI in pathological versus uncomplicated pregnancies: a value-add to right and left mod-MPI? 23rd World Congress on Ultrasound in Obstetrics and Gynaecology, Sydney 2013. Henry A, Shand A, Crowther C, Palmer A, Wang YA, Welsh AW. Comprehensive ultrasound evaluation of short-term fetal effects of dexamethasone and betamethasone. 23rd World Congress on Ultrasound in Obstetrics and Gynaecology, Sydney, 2013. Homer C, Brodie P, Copeland F, Rumsey M, Dawson A. We kam longwe so far: Building midwifery capacity in Papua New Guinea. Pacific Society for Reproductive Health Conference, July Apia, Samoa 2013. Kanade T, Kulkarni S A, Sheregar N. Laparoscopic management of grade IV endometriosis – TRICKS OF TRADE. 41st Annual Conference of Mumbai Obstetrics and Gynaecologic Society (MOGS). Juhu, Mumbai 2013. Meriki N, Henry A, Sanderson J, Mahajan A, Wu L, Welsh AW. Normal ranges for the right modified myocardial performance index (RMPI) in the Australian population using three alternative caliper placements. 23rd World Congress on Ultrasound in Obstetrics and Gynaecology, Sydney, 2013. Chapman MG. Guideline preparation. RANZCOG CREI Annual Meeting, Sydney, 2013. Chwah S, Reilly A, Hall B, Henry A. Midwifery-led intervention group for pregnant women of high body mass index: engagement with and outcomes of SSWInG. RANZCOG Annual Scientific Meeting, Sydney, S2013 (e-poster). Everitt L, Homer C, Fenwick J. Assumption of care of a newborn: How can you be prepared? Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26: S1: S6. Hammond A, Foureur M, Homer C, Davis D. The hospital birth environment: Impacts on midwifery practice during labour and birth. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S8. Henry A, Lees N, Bein K, Hall B, Lim V, Chen K, Welsh A, Hui L, Shand AW. Pregnancy outcomes before and after institution of specialised Twins Clinic Care. RANZCOG 2013 Annual Scientific Meeting, Sydney, 2013. Homer C, Rumsey M, Brodie P, Dawson A, Copeland F, Daly J. (2013). Helping build foundations to improved maternal health in PNG. International Council of Nurses 25th Quadrennial Congress, Melbourne 2013. Homer C. Connections, Continuity and Community: Models of care for Aboriginal and Torres Strait Islander women. Perinatal Society of Australia and NZ 17th Annual Congress. April, Adelaide, Australia. Abstract published in J Paed Child Health 2013;49:S2: 7. O’Connor M. Sexual Violence as a Weapon in Armed Conflict. 40th World Congress of Military Medicine. Jeddah. Kingdom of Saudi Arabia, 2013. King K, Foo J, Henry A. Third trimester ultrasound: an audit of current practices at St George Hospital. RANZCOG Annual Scientific Meeting, Sydney, 2013. Chapman MG. Invited Speaker: Other Than Kangaroos, Does Australia Have Anything to Offer In Reproduction? Midwestern Reproductive Symposium, Chicago, IL, USA, 2013. Kruske S, Schmied V, Homer C. Midwives confidence in the skills required for postnatal care: Results of a national survey. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S11. 2013 - National Austin K, Chambers G, Susic D, Madan A, De Abreu Lourenco R, Henry A. Cost Effectiveness of induction of Labour at term with inpatient vaginal prostaglandin E2 gel compared to an outpatient Foley Catheter (FOG Trial). Royal Australian and New Zealand College of Obstetrics 124 Moody T, Fenwick J, Foureur M, Homer C, Davis D Exploring ‘domesticity’ in the birthspace. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S14. O’Connor M. Legal Protection for ADF Medical Officers in a Quasi Authoritarian Organisation. NSW Military Health Lecture, Randwick Barracks 2013 Raymond J, Homer C, Davis D. The Who, What and Why: Weight management support for obese women during pregnancy. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S15. Pettit F, Davis G, Henry A, Mangos G, Brown MA. Is early onset pre-eclampsia worse for mother or baby? Perinatal Society of Australia and New Zealand Annual Scientific Meeting, Perth, 2013. Psaila K, Schmied V, Kruske S, Homer C. Transition of care: how well is it done? Findings from the CHoRUS study. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S18. Whitton K, Shand A, Pasfield A, Nassar N, McShane M, Han X, Henry A. Anti-Mullerian hormone: a predictor of adverse pregnancy events? PSANZ Annual Scientific Meeting, Adelaide, 2013. 125 Nursing and Midwifery Centre for Research in Nursing and Health > 128 > Centre for Research in Nursing and Health Director of Nursing and Midwifery Vicki Manning RN, BAdmin (Nursing), MPH Centre for Research in Nursing and Health Professor Ritin Fernandez RN, PhD School of Nursing and Midwifery - University of Wollongong St George Hospital Daniela Levido (Stomal Therapy Clinical Nurse Consultant, Graduate Certificate in Stomal Therapy, BN) Suzanne Polis (BN, MPH by research, Post grad certificate in Gastroenterology & Hepatology, PhD candidate) Megan Higgs (BN, MN, PhD candidate) Research Grants Craig D, Fernandez R (2013) Clinical Management of Chinese speaking women with Gestational Diabetes Mellitus speaking women with Gestational Diabetes. St George Hospital: Multicultural Health Service Cultural Diversity Health Enhancement Grants Program 20122013. $6,800 Curtis K, Foster K, Mitchell R (2013) Paediatric Critical Injury Research Program (6 years). South Eastern Sydney Local Health District (SESLHD): Day of Difference. 574,223 Curtis K, Goldsmith H, Langcake M (2013) Improving outpatient pain management. South Eastern Sydney Local Health District (SESLHD): Motor Accidents Authority of NSW. $13, 676 Curtis K, Murphy M, Hardy J, Lewis M, Strachan L, Buckley DT (2012) Evaluation of an emergency nursing assessment framework on patient assessment and documentation: A pilot study South Eastern Sydney Local Health District (SESLHD): Emergency Care Institute. $99,457.60 Curtis K, Roberts L, Langcake M (2013) Improving the care and outcomes of patients with blunt chest injury. South Eastern Sydney Local Health District (SESLHD): Motor Accidents Authority of NSW. $14,814 Falomir C (2013) Cancer Information CALD Wall and DVD library. South Eastern Sydney Local Health District (SESLHD): Multicultural Health Service Cultural Diversity $1800 Fernandez R (2012) Secondary prevention following PCI. 128 South Eastern Sydney Local Health District (SESLHD): University of Wollongong $20,000 Fernandez R, Arthur B (2013) Dementia education for acute care nurses: NSW Ministry of Health, Dementia Training Study Centres $50,000 Fernandez R, Higgs M (2013) Perception of cardiovascular risk among offsprings of people with acute coronary syndrome. South Eastern Sydney Local Health District (SESLHD): University of Wollongong $5000 George R, Straube B, Cook C, Gallard J, et al. (20132015) Enhancing Intravenous Cannula Care by Patients from Culturally and Linguistically Diverse Backgrounds (ENABLE). SESLHD: Multicultural health service, Cultural Diversity Health Enhancement Grants $5,000 Murray N, Griffith J (2012) Arabic Centering in Pregnancy. South Eastern Sydney Local Health District (SESLHD): Multicultural Health. $8511 Matthews L, Griffith J (2012) Ways of Working (WOW). Maternity Services, St George Hospital: Nurse & Midwifery Office Strategy $16,192 Polis S (2013) Adherence to Hepatitis B anti-viral medications. St George Hospital: Gilead Sciences. $13,000 Polis S, Pritchard -Jones J (2013) Education needs of hepatology nursing staff working with patients diagnosed with HCV and HBV related advanced liver disease. St George Hospital: Pillar Award for Nursing & Allied Health. Roche Pharmaceuticals. $10,000 Polis S, Zekry A, Fernandez R (2013) Effect of a nurse directed model of outpatient care for management of patients with advanced liver disease: a pilot study St George Hospital: St George & Sutherland Medical Research Foundation. $20,000 Ho S, Cook C, Straube B, Fernandez R, et al. (2013-2014) The Action Study: Strategies to reduce the VRE infection (Transmission and BacteraemIa) rates in high risk patients admitted to 4E/4N wards. SESLHD: SESLHD Infection Prevention & Control Enhancement Program. $100,000 Wiseman T, Curtis K, West S (2013) E-learning to improve trauma care on the wards. South Eastern Sydney Local Health District (SESLHD): Motor Accidents Authority of NSW. $14, 717. Original Peer Reviewed Publications Asha S, Curtis KA, Grant N, Taylor C, Lo S, Smart R, Compagnoni K (2012) Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a panscan protocol. Emergency Medicine Australasia 24:43-51. Asha SE, Ajami A (2013) Improvement in emergency department length of stay using an early senior medical assessment and streaming model of care: A cohort study. Emergency Medicine Australasia 25:445-451. Asha SE, Curtis KA, Taylor C, Kwok A (2013) Patientcontrolled analgesia compared with interval analgesic dosing for reducing complications in blunt thoracic trauma: a retrospective cohort study. Emergency Medicine Journal 30:1024-1028. Blay N, Glover S, Bothe J, Lee S, Lamont F (2012) Substance users’ perspective of pain management in the acute care environment. Contemporary Nurse 42:289-297. Brown MA, Roberts LM, Mackenzie C, Mangos G, Davis GK (2012) A prospective randomized study of automated versus mercury blood pressure recordings in hypertensive pregnancy (PRAM Study) Hypertension in Pregnancy 31:107-119. Burns T (2013) Waiting for a kidney transplant in Australialatest trends. Transplant Journal of Australasia 22:10. Burns T (2013) Nutritional Management of Renal Disease. Renal Society of Australasia Journal 9:143. Clements A, Curtis K (2012) What is the impact of nursing roles in hospital patient resuscitation? Australasian Emergency Nursing Journal 15:108-115. Clohessy P, Polis S, Post J (2013) Spontaneous clearance of hepatitis C virus during pregnancy. Obstetric Medicine: The Medicine of Pregnancy 6:28-29. Connell T, Fernandez RS, Tran D, Griffiths R, Harlum J, Agar M (2013) Quality of life of community-based palliative care clients and their caregivers. Palliative Support Care 11:323-330. Cuesta C, Blow T, Tranter S (2013) Epidermolysis bullosa: a rare challenge for peritoneal dialysis nurses. Renal Society of Australasia 9:41-44. Curtis K, Caldwell E, Delprado A, Munroe B (2012) Traumatic injury in Australia and New Zealand. Australasian Emergency Nursing Journal 15:45-54. Curtis K, Chan DL, Lam MK, Mitchell R, King K, Leonard L, D’Amours S, Black D (2013) The injury profile and acute treatment costs of major trauma in older people in New South Wales. Australasian Journal on Ageing. DOI: 10.1111/ajag.12059 Curtis K, Leonard E (2012) The Trauma Nurse Coordinator in Australia and New Zealand: Demographics, Role, and Professional Development. Journal of Trauma Nursing 19:214-220. Curtis KA, Mitchell RJ, Chong SS, Balogh ZJ, Reed DJ, Clark PT, D’Amours S, Black DA, Langcake ME, Taylor CB (2012) Injury trends and mortality in adult patients with major trauma in New South Wales. Medical Journal of Australia 197:233. Dinh MM, Curtis K, Ivers R (2013) The effectiveness of helmets in reducing head injuries and hospital treatment costs: a multicentre study. Medical Journal of Australia 198:415, 417. Dinning PG, Hunt LM, Arkwright JW, Patton V, Szczesniak MM, Wiklendt L, Davidson JB, Lubowski DZ, Cook IJ (2012) Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slowtransit constipation. British Journal of Surgery 99:10021010. Dinning PG, Wiklendt L, Gibbins I, Patton V, Bampton P, Lubowski DZ, Cook IJ, Arkwright JW (2013) Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber-optic high-resolution manometry studies. Neurogastroenterology Motility 25:e640-649. Dunford M, ACI-ICCMU Tracheostomy Expert Group (2013) Care of Adult Patients in Acute Care Facilities with a Tracheostomy Clinical Practice Guideline. Sydney: Agency for Clinical Innovation. Dutton M, Curtis K (2012) Well-wound therapy: use of Negative Pressure Wound Therapy to prevent laparotomy breakdown. Journal of Wound Care 21(8) 386-388 Everett B, Salamonson Y, Trajkovski S, Fernandez R (2013) Demographic and academic-related differences between 129 standard-entry and graduate-entry nursing students: A prospective correlational survey. Nurse Education Today 33:709-713. Everitt L (2013) Collaboration matters: Working with ‘chaotic’ complex women: A case study. Midwifery Matters Newsletter of the Australian College of Midwives-NSW Branch Incorporated 32:14-15. Everitt L (2013) The experiences of midwives working with the removal of newborns for child protection concerns in NSW, Australia: Being in the headspace and heart space. UTS Digital Theses Collection 1-133. Everitt L (2013) Research Matters: Assumption of care of newborns in maternity units. Midwifery Matters Newsletter of the Australian College of Midwives-NSW Branch Incorporated 32:10-11. Fernandez R, Griffiths R (2012) Water for wound cleansing. Cochrane Database Syst Rev 15 DOI 101002/14651858CD003861pub3. Fernandez R, Johnson M, Tran DT, Miranda C (2012) Models of care in nursing: a systematic review. International Journal of Evidence Based Health Care 10:324-337. Fernandez R, Rajaratnam R, Evans K, Speizer A (2012) Goal setting in cardiac rehabilitation: implications for clinical practice. Contemporary Nurse 43:13-21. Fernandez R, Salamonson Y, Griffiths R (2012) Emotional intelligence as a predictor of academic performance in first-year accelerated graduate entry nursing students. Journal of Clinical Nursing 21:3485-3492. Fernandez RS, Frost S (2013) Congruence between the Indian Diabetes Risk Score and Australian Type 2 Diabetes Risk Assessment tool screening in Asian-Indians. Nurse Researcher 21:36-39. Fernandez RS, Tran DT, Ramjan L, Ho C, Gill B (2012) Comparison of four teaching methods on Evidence-based Practice skills of postgraduate nursing students. Nurse Education Today Online early view. Fry M, MacGregor C, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet W (2013) Nursing praxis, compassionate caring and interpersonal relations: An observational study. Australasian Emergency Nursing Journal 16:37-44. Fry M, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet W (2012) Managing the wait: Clinical initiative nurses’ perceptions of an extended practice role. Australasian Emergency Nursing Journal 15:202-210. Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, Steel T, Nau T (2012) Road trauma, patterns of injury and mortality in an Australian trauma centre. Journal of the Australasian College of Road Safety 23:21. Graham J, Gallagher R, Bothe J (2013) Nurses’ discharge planning and risk assessment: behaviours, understanding and barriers. Journal of Clinical Nursing 22:2338-2346. Hawkins TA, Roberts J, Mangos G, Davis G, Roberts L, Brown M (2012) Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. British Journal of Obstetrics & Gynaecology: An International Journal of Obstetrics & Gynaecology 119:484-492. Josland E (2013) Quality of Life. What information is already available and what evidence is this based on? Nephrology On Line early view DOI: 10.1111/nep.12072. Josland E, Brennan F, Anastasiou A, Brown MA (2012) Developing and sustaining a renal supportive care service for people with end-stage kidney disease. Renal Society of Australasia Journal, 8 (1) 12-18. Josland E (2013) Book review Kidney disease: From advanced disease to bereavement. Second edition. The Renal Society of Australasia Journal 9:142. Mahashabde R, Fernandez R, Sabnis S (2013) Validity and reliability of the aneroid sphygmomanometer using a paediatric size cuff for craniocervical flexion test. International Journal of Evidence‐Based Healthcare 11:285-290. Feild D (2013) Book Review: Understanding chronic kidney disease a guide for non-specialists. Renal Society of Australasia Journal 9:45. McIntosh AS, Curtis K, Rankin T, Cox M, Pang T, McCrory P, Finch C (2013) Associations between helmet use and brain injuries amongst injured pedal-and motor-cyclists: A case series analysis of trauma centre presentations. Journal of the Australasian College of Road Safety 24:11. Fry M, Horvat L, Roche M, Fong J, Plowes J (2012) The prevalence and triage characteristics of patients presenting with infection to one tertiary referral hospital. Australasian Emergency Nursing Journal 15:127-132. Mitchell R, Curtis K, Fisher M (2012) Understanding Trauma as a Men’s Health Issue: Sex Differences in Traumatic Injury Presentations at a Level 1 Trauma Center in Australia. Journal of Trauma Nursing 19:80-88. Fry M, Horvat L, Roche M, Fong J, Plowes J (2013) A four month prospective descriptive exploratory study of patients receiving antibiotics in one Emergency Department. International Emergency Nursing 21:163-167. Mitchell R, Watson WL, Curtis K, Harris I, McDougall P (2012) Difficulties in establishing long-term trauma outcomes data collections. Could trauma outcomes be routinely monitored in New South Wales, Australia: 130 Piloting a 3 month follow-up? Injury 43:96-102. Mitchell RJ, Curtis K, Chong S, Holland AJ, Soundappan S, Wilson KL, Cass DT (2013) Comparative analysis of trends in paediatric trauma outcomes in New South Wales, Australia. Injury 44:97-103. Mitchell RJ, Curtis K, Holland AJ, Balogh ZJ, Evans J, Wilson KL (2013) Acute costs and predictors of higher treatment costs for major paediatric trauma in New South Wales, Australia. Journal of Paediatrics and Child Health 49:557-563. Moore S (2013) Management of multi-resistant organisms (MRO) in the perioperative environment study tour. ACORN: The Journal of Perioperative Nursing in Australia 26:18. Morris P (2013) Understanding the experience of a cancer diagnosis and illness--A patient perspective of the biographical disruption of multiple myeloma. Australian Journal of Cancer Nursing 14:20. Moustakas J, Bennett P, Tranter S, Nicholson J (2012) The needs of older people with advanced chronic kidney disease choosing supportive care: a review. The Renal Society of Australasia Journal 8:70-75. Munroe B, Curtis K, Considine J, Buckley T (2013) The impact structured patient assessment frameworks have on patient care: an integrative review. Journal of Clinical Nursing 22:2991-3005. Ogilvie R, McCloughen A, Curtis K, Foster K (2012) The experience of surviving life‐threatening injury: a qualitative synthesis. International Nursing Review 59:312-320. Patton V, Wiklendt L, Arkwright JW, Lubowski DZ, Dinning PG (2013) The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence. British Journal of Surgery 100:959-968. heterogeneity of Australian nursing students: a closer look. International Nursing Review 59:59-65. Sorensen R, Paull G, Magann L, Davis J (2013) Managing between the agendas: implementing health care reform policy in an acute care hospital. Journal of Health Organization and Management 27:698-713. Taylor C, Jan S, Curtis K, Tzannes A, Li Q, Palmer C, Dickson C, Myburgh J (2012) The cost-effectiveness of physician staffed Helicopter Emergency Medical Service (HEMS) transport to a major trauma centre in NSW, Australia. Injury 43:1843-1849. Taylor CB, Curtis K, Jan S, Newcombe M (2013) Helicopter Emergency Medical Services (HEMS) over-triage and the financial implications for major trauma centres in NSW, Australia. BMC Emergency Medicine 13:11. Tranter S, Anastasiou A, Bazzi H, Burgess H, Josland E (2013) The renal memorial service: an important component of renal supportive care. Renal Society of Australasia Journal 9:80-84. Wang DH, Blenman N, Maunder S, Patton V, Arkwright J (2013) An optical fiber Bragg grating force sensor for monitoring sub-bandage pressure during compression therapy. Optics Express 21:19799-19807. Westgarth F, Chiarella M, Tranter S (2012) The haemodialysis Models of care Program. The Renal Society of Australasia Journal 8:24-31. Willenberg L, Curtis K, Taylor C, Jan S, Glass P, Myburgh J (2012) The variation of acute treatment costs of trauma in high-income countries. BMC Health Services Research 12:267. Wiseman T, Foster K, Curtis K (2013) Mental health following traumatic physical injury: An integrative literature review. Injury 44:1383-1390. Presentations at Conferences and Meetings Pianta TJ, Horvath AR, Ellis VM, Leonetti R, Moffat C, Josland EA, Brown MA (2012) Cardiac high‐sensitivity troponin T measurement: A layer of complexity in managing haemodialysis patients. Nephrology 17:636641. Abraham E, Patton V, Lutton N, Lubowski D (2012) The cutting seton. Annual Scientific Congress, RACS Kuala Lumpur, Malaysia. Rolley J, Fernandez R, Everett B, Mohan S, Davidson PM (2012) Factors associated with dietary practices and heart disease prevention among Indian Australians: a focus group study. Heart, Lung and Circulation 21:S308. Abraham E, Patton V, Lutton N, Lubowski D (2012) Sacral nerve stimulation for faecal incontinence - our institution’s experience. Annual Scientific Congress, RACS Kuala Lumpur, Malaysia. Rolley J, Fernandez R, Everett B, Mohan S, Davidson PM (2012) Perceptions of medication taking among Asian Indian Australians: a focus group study. Heart, Lung and Circulation 21:S312. Ajami A (2012) The First Aid Skills Training (FAST) Project. Multicultural health research to practice forum: St George Hospital, NSW. Salamonson Y, Ramjan L, Lombardo L, Lanser LH, Fernandez R, Griffiths R (2012) Diversity and demographic Ajami A, Chan DT (2012) Medical Assessment and Decision Making in Emergency (MADMEN) Project. Australasian Redesigning Healthcare Summit, Brisbane. 131 Awad S, Cooper N, Department E (2013) ED Versus the Ward. Can secondments improve clinician relationship and development of knowledge and skills. Council of Children’s Nurses Conference: Winds of Change: Homebush, NSW. Curtis K (2013) Keynote speaker 8th Annual Critical Care Conference Vineyards, Hunter Valley, NSW. Curtis K (2012) 2012 Vision, Challenges, and New Frontiers in Emergency Care. 10th International Conference for Emergency Nursing: Hobart. Brown M, Collett G, Josland E, Brennan B (2013) Nondialysis management in the elderly: survival, sympton control and quality of life. ASN Kidney Week: Atlanta Georgia USA. Burns, L (2012) Curtis K (2013) Management of massive haemorrhage in trauma. International Conference for Emergency Nurses: Melbourne. Burns, L (2012) Minimal Space, No Extra Nurses but Lots of Patients – Finding a New Way to Increase Capacity. Haematological Society of Australia and New Zealand, Melbourne November. Curtis K, Chan D (2013) . The injury profile and acute treatment costs of major trauma in older people in New South Wales. Trauma Surgery Section of the Royal Australasian College of Surgeons Annual Scientific Congress: Auckland, New Zealand. Burns, L (2012) Minimal Space, No Extra Nurses but Lots of Patients – Finding a New Way to Increase Capacity. (Presentation & Poster) National Health Roundtable Innovation Awards, October 2012. Sydney, Australia (Winner of National Innovator of the year, nominated for a Premier’s award 2012). Burns L, Morris K (2012) Improving the Cancer Journey – Introduction of a Nurse-Run Clinic for Patients Finishing Treatment for Cancer. The Annual Scientific Meeting of the HAA (Haematology Society of Australia and New Zealand, HSANZ, the Australian & New Zealand Society of Blood Transfusion, ANZSBT, and the Australasian Society of Thrombosis and Haemostasis - ASTH) and the Asian-Pacific Society on Thrombosis and Haemostasis: Melbourne Burns T, Fernandez R, Stephens M (2013) Waiting for a kidney transplant - a literature review. Transplant Nurses of Australasia Annual Conference Sydney, NSW. Chandrasekhar J, Paull G, Youssef G, Weaver J, Rees D (2012) Single Centre Clinical Experience and Discharge planning using high sensitivity troponin T post Elective PCI. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand Brisbane. Cryer J.A (2012) Ten years on and still going strong. International Cancer Nurses Conference: Prague. Cuesta A, Tranter, S. & Blow, T (2012) Caring for a patient with Epidermolysis Bullosa on Peritoneal Dialysis. Renal Society of Australasia 40th Annual Conference: Melbourne, VIC. Cuesta A (2013) Addressing Peritoneal Dialysis Related Infection. Nephrology workshop: Sydney, NSW. Cuesta A, Tranter S, Blow T (2013) Taking control: addressing peritoneal dialysis related infection outcomes. Renal Society of Australasia Conference: Hobart. Curtis K (2012) Invited speaker – case reviews. Swan XX Trauma Conference: Sydney. 132 Curtis K, Clements A, Curtis K, Holzhauser K, Horvat L (2012) The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. Trauma 2012 Conference: Perth. Curtis K, Clements A, Holzhauser K, Horvat L (2012) The impact of a senior nurse as nurse team leader on communication and perceptions of leadership in major trauma resuscitations. 10th International Conference for Emergency Nursing: Hobart. Curtis K, Crouch R, Palfrey R, McHale H (2013) Trauma Nurse Coordinators in England Major Trauma Coordinator National Conference: Salford, England. Curtis K, Dutton M, Chiarella M (2012) The current state of knowledge into role, context of practice and impact of the wound care nurse. 4th Congress of the World Union of Wound Healing Societies Better Care, Better Life: Yokohama Japan. Curtis K, Dutton M, Chiarella M (2012) The current state of knowledge into role, context of practice and impact of the wound care nurse. 10th National Australian Wound Management Association Conference: Sydney Convention & Exhibition Centre. Curtis K, Frydenberg E, Chong S, Poulos R, Grzebieta R, Steel T, Nau T (2012) Road Trauma, Patterns of Injury and Mortality in an Australian Trauma Centre. Neurosurgery Section of the Royal Australasian College of Surgeons’ Annual Scientific Congress: Kuala Lumpur, Malaysia. Curtis K, Kennedy B, Waters D (2013) The Personality Characteristics of Emergency Nurses. International Conference for Emergency Nurses: Melbourne. Curtis K, Lam M, Mitchell R, Black D, al e (2012) Acute costs and predictors of higher treatment costs of trauma in New South Wales, Australia. Trauma 2012 Conference: Perth. Curtis K, Leonard E (2012) A snapshot: Resources currently available in trauma services throughout Australia and New Zealand. Trauma 2012 Conference: Perth. Curtis K, Mitchell R, al. e (2013) Acute care costs and predictors of higher treatment costs for major paediatric trauma in NSW. 11th Australasian Injury Prevention & Safety Promotion Conference: Fremantle, WA. Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2012) Injury trends and mortality in adult patients with major trauma in NSW. 10th International Conference for Emergency Nursing: Hobart. Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2012) Injury trends and mortality in adult patients with major trauma in NSW. Trauma 2012 Conference: Perth. Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2013) Injury trends and mortality in adult patients with major trauma in New South Wales, Australia. Unlocking the Value of Mortality Data Workshop: Sydney. Curtis K, Munroe B, Curtis K, Buckley T, Considine J (2012) The impact of a structured patient assessment on patients and clinicians. 10th International Conference for Emergency Nursing: Hobart. Curtis K, Ogilvie R, Palmer C, Lam M, McCloughen A, Foster K (2013) Incidence and outcomes of major traumatic injury in the Australian Capital Territory. Canberra Health Annual Research Meeting (CHARM): Canberra, ACT. Curtis K, Ogilvie R, Palmer C, Lam M, McCloughen A, Foster K (2013) Incidence and outcomes of major traumatic injury in the Australian Capital Territory. International Conference for Emergency Nurses: Melbourne. Curtis K, Wiseman T, Foster K (2013) The incidence of depression, anxiety and stress (DAS) in trauma patients during hospital admission and 3 months post injury. Queensland Trauma Symposium Brisbane, QLD. Davis G, Roberts L, Mangos G, Brown M (2012) The UM101 mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? XVIII ISSHP World Congress: Geneva, Switzerland. Decker V (2013) Regular Interprofessional Simulation Cases. STG POWH ICU Symposium Sydney. Dinning P, Patton V, Hunt L, Gebski V, Jones M, Stewart P, Lubowski D, Cook I (2013) Efficacy of sacral nerve stimulation for severe slow transit constipation -a randomised double-blind placebo-controlled crossover study. . American Society of Colon and Rectal Surgeons Annual Meeting: Phoenix Arizona. Everitt L (2012) Assumption of Care. St George / Sutherland Hospitals & Health Services (SGSHHS) Annual Midwifery Seminar Working Together: Kogarah. Everitt L (2012) Learning to play the hard course: Midwives role in assumption of care of newborns. Australian College Midwives – NSW Branch Inc. Annual State Conference: Wyong, NSW. Everitt L, Homer C, Fenwick J (2012) Midwives Experience of Working with Community Services during Assumption of Care of Newborns. 4th Biennial Breathing New Life into maternity Care Multidisciplinary Conference: Melbourne, Victoria. Everitt L, Homer C, Fenwick J (2013) Assumption of Care of a Newborn: How can you be prepared? Australian College of Midwives, 18th National Conference: Hobart, Tasmania. Everitt L, Lock K, Fenwick J, Homer C (2012) Breastfeeding and assumption of care of newborns. . The Inaugural Lactation Consultants of Australia and New Zealand (LCANZ) Conference Sydney, NSW. Griffith J (2012) Understanding 1:1 midwifery care. NSW Health Towards Normal Birth State-wide Workshop: Sydney, NSW. Griffith J (2013) Rural maternity: what’s so different? UTS Bachelor of Midwifery (Year 3) Day: Sydney, NSW. Griffith J, Best P (2012) Ways of Working in Maternity Care. St George Midwifery Conference: Kogarah, NSW. Griffith J, Best P (2012) Ways of Working in Maternity Care. SESLHD Executive Forum: Randwick, NSW. Hodges K, Jones S (2013) Multidisciplinary ward round project. STG POWH ICU Symposium Sydney. Davis S, Paull G, Vuong N, Connolly B, Ang E (2012) ICD’s and PTSD: a shocking story - from crisis to recovery. Australian Cardiovascular Health and Rehabilitation Association Conference Kirribilli, NSW. Horvat L, Fry M, Plowes J, Fong J (2012) To explore the nursing assessment and initial management of septic patients in the Emergency Department. Annual Critical Care Conference Hunter Valley, NSW. Davis S, Paull G, Vuong N, Connolly B, Ang E (2012) ICD’s and PTSD: a shocking story - from crisis to recovery. Australian Cardiovascular Health and Rehabilitation Association Conference: Brisbane, QLD. Jacques E (2012) HCC Nurse Coordinator: Impact on MDT Model and Patient Education. 8th Australasian Viral Hepatitis Conference: Auckland, NZ. 133 Jones S (2013) Pressure injury prevention for critically ill patients Guidelines. The ACI Intensive Care Coordination and Monitoring Unit (ICCMU): Sydney. Josland E (2012) Hepatitis Protocols: Opening a can of worms. RSA 40th Annual Conference: Melbourne, VIC. Josland E (2012) Renal Supportive Care: Holistic care for ESKD patients and their families. RSA 40th Annual Conference: Melbourne, VIC. Josland E, Collett G, Brennan F, Foote C, Brown M (2012) HOPE: Helping Older People with ESKD. International Forum on Quality and Safety in Healthcare: Le Palais des Congress, Paris, France. Keating L (2013) Measurement of temperature in critically ill adults: A systematic review and clinical practice guideline. . The Australian and New Zealand Intensive Care Society (ANZICS) Conference: Hobart, Tasmania. Keating P (2013) Manual Handling Equipment in St George Hospital. Statina International Conference: Homebush Sydney. Keating P (2013) Perioperative Introduction Programme to Tongan Nurses. Orthopaedic Outreach: Tonga. Kennedy B (2013) Personality Characteristics of Emergency Nurses College of Emergency Nursing Australasia (CENA) Conference: Melbourne. Lafferty M (2012) Improving care in RACF - a Model to improve care and communication- NSW Palliative care NSW Palliative Care Dubbo. Lock K (2013) Vulnerable Population groups: Innovative Models of Care at two Baby Friendly Health Accredited hospitals. International Lactation Consultant Association Conference: Melbourne, Victoria. Magann L (2012) Benefits of early referral to palliative care, symptom management and end of life conversations Australian Hepatoly Summit: Sydney. Martinez-Smith Y, Meek C (2012) “Collaboration in Care”. Home Therapies Workshop: Sydney, NSW. Martinez-Smith Y, Meek C (2012) Oral presentation – “Collaboration in Care”. Home Therapies Workshop: Sydney, NSW. McCarthy F, Falomir C (2012) Solution to safe storage. Innovation in work health and Safety: St George Hospital, Sydney. Meek C (2013) Safeguarding veins – the use of a Save the Vein Tattoo. Renal Society of Australasia Annual Conference: Hobart. 134 Meek C (2013) Transitioning onto Haemodialysis Evaluating the effectiveness of a new educational resource. Renal Society of Australasia Annual Conference: Hobart, TAS. Modester T (2012) Fractured Neck of Femur. Australian Orthopaedic Nurses’ Association Annual Conference: Homebush, NSW. Moore S (2012) Perioperative Management of Patients with MROs Centre for Infectious Diseases and Microbiology Public Health Conference Westmead Hospital, Sydney Australia. Moore S (2012) Understanding Health Fund Contracts. Day Surgery Nurses Association State Conference: Sydney, Australia. Moustakas J, Bennett P, Tranter S, Nicholson J (2012) Supportive care: what does the patient want? Renal Society of Australasia 40th Annual Conference: Melbourne, VIC. Patton V (2012) Antegrade colonic enema administered via Chait Cecostomy Catheter. World Council of Enterostomal Therapists: Adelaide . Patton V (2013 ) Are anorectal physiology tests useful in asymptomatic primiparous patients with OASIS obstetric anal sphincter injuries? Royal Australian and New Zealand College of Obstetricians and Gynaecologists 2013 Annual Scientific Meeting (RANZCOG 2013 ASM): Sydney, NSW. Patton V, Dinning P, Lubowski DZ, Arkwright J, King D (2012) Colonic manometry demonstrates the mode of action of sacral nerve stimulation in patients with faecal incontinence Joint International Meeting in Neurogastroenterology and Motility Bolongna Italy. Patton V, Lubowski D (2012) Sacral nerve stimulation modifies colonic motility in patients with faecal incontinence. International Society of University Colon and Rectal Surgeon (ISUCRS) Congress: Bologna. Patton V, Lubowski D (2013) Antegrade colonic enema via a Chait caecostomy catheter - is it a viable option for adult bowel management?, American Society of Colon and Rectal Surgeons Annual Meeting: Phoenix Arizona. Patton V, Lubowski D (2013) Sacral nerve stimulation for slow transit constipation. St George Medical Research Conference Sydney, NSW. Patton V, Lubowski D (2013) Sacral nerve stimulation: why do patients fail PNE? American Society of Colon and Rectal Surgeons Annual Meeting: Phoenix Arizona. Paull G (2012) Self-management: Multilingual Audio-visual Resources for People with Ischaemic Heart Disease and Chronic Heart Failure Australasian Cardiovascular Nursing College, The Ageing Heart Conference: Sydney, NSW. Paull G, Gallagher R, Horvath R, Chen D (2012) Discrimination and high sensitivity cardiac troponin: the relationship between clinical presentation, clinical request and discharge diagnosis. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand Brisbane, QLD. Polis S, Matisan A, Mainali B, al e (2012) Patient adherence to lactulose to minimise the risk of Hepatic Encephalopathy. 8th Australasian Viral Hepatitis Conference Auckland, New Zealand. escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference Hunter Valley, NSW Romero B, Ajami A, Bayeh G, Neuhaus L, Foreshew M, Cosgrove J (2012) To identify delay reasons for Ed patients at 4 and 8 hours allowing the early identification and escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference: Hunter Valley, NSW. Polis S, Wheeler E, Richmond J (2012) Developing Hepatitis B virus education for registered nurses. Australasian Viral hepatitis Conference: Auckland, New Zealand. Sorensen R, Paull G, Magaan L, Davis J (2012) Is poor quality of care built into the system? Evidence from a study on communication among teams treating people dying in hospital 8th International Organisational Behaviour in Healthcare Conference - Patient-centred healthcare teams: achieving collaboration, communication and care: Dublin, Ireland. Polis S, Wheeler E, Richmond J (2012) Evaluation of Hepatitis B Virus education for registered nurses. Australasian Viral hepatitis Conference: Auckland, New Zealand. Speizer A, Fernandez R (2012) Goal setting in cardiac rehabilitation: Implications for clinical practice. The Australian Cardiovascular Health and Rehabilitation Association Conference Brisbane. Polis S, Zekry A, Maher L (2012) Adherence to anti-viral medications: a qualitative study. Australasian Viral hepatitis Conference: Auckland, New Zealand. Szwajcer A (2012) Supporting Young Women with Breast Cancer. International Cancer Nurses Conference: Prague. Reilly A, Everitt L, Murray N (2013) Young Mum’s Group: Unexpected Lessons. Australian College of Midwives, 18th National Conference: Life, Art and Science in Midwifery: Hobart, Tasmania. Roberts L (2012) Hypertension in pregnancy- practice and evidence. Australian College of Midwives National Webinar Series. Roberts L, Davis G, Mangos G, Brown M (2012) The UM101 mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? St George and Sutherland Medical Research Foundation Symposium: Kogarah, NSW. Robertson F (2012) Breastfeeding and High Risk Pregnancy. Annual St George Breastfeeding Conference: Kogarah, NSW. Rolley J, Fernandez R, Everett B, Mohan S, Davidson P (2012) Factors Associated with Dietary Practices and Heart Disease Prevention Among Indian Australians: A Focus Group Study. Cardiac Society of Australia and New Zealand: Brisbane. Rolley J, Fernandez R, Everett B, Mohan S, Davidson P (2012) Perception of Medication Taking Among Asian Indian Australians: A Focus Group Study. Cardiac Society of Australia and New Zealand: Brisbane. Tranter S (2013) Management of CKD Innovative approaches to best practice: chronic disease management in the Community workshop - GP NSW: Sydney, NSW. Tranter S, Josland E (2013) Association of nutritional status and the future choice of dialysis option in patients attending the multidisciplinary predialysis assessment clinic. Renal Society of Australasia Conference: Hobart. Tranter S, Josland E (2013) Nutritional profile of patients at enrolment to the multidisciplinary predialysis clinic 20022012. Renal Society of Australasia Conference: Hobart. Turner K, Burns T (2013) The role of a renal transplant recipient coordinator in a non-transplanting unit. Transplant Nurses of Australasia Annual Conference Sydney, NSW. Manning, V (2012) To NUM or not to NUM – that is the question? Leadership and Practice Development in Health: Quality and Safety through Workplace Learning Conference: Hobart. Walter L (2013) Impact from point of care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and costeffectiveness analysis. International Conference of Emergency Nursing: Melbourne. Romero B (2012) The emergency flow Coordinator International Conference of Emergency Nursing: Hobart. Romero B (2012) To identify delay reasons for ED patients at 4 and 8 hours allowing the early identification and 135 SOUTH EASTERN SYDNEY LABORATORY SERVICES Anatomical Pathology > 137 > Anatomical Pathology (SEALS) St George Hospital Head of Department Dr Con Theocharous MBBS FRCPA, Conjoint Lecturer UNSW Senior Medical Dr Leon Vonthethoff MBBS FRCPA Dr Veli Marjoniemi MBBS BSc FRCPA, Conjoint Senior Lecturer UNSW Dr Kim Tran MBBS FRCPA, Conjoint Lecturer UNSW Dr Jill Griffith BMed(Hons) FRCPA Dr Louella Davey MBBS FRCPA A/Prof Ewan Millar BSc(Hons) MBChB FRCPath FRCPA MD FFSc(RCPA), Conjoint Assoc Prof UNSW & UWS; Visiting Pathologist Kinghorn Cancer Centre & Garvan Institute of Medical Research. Research Staff Julia Beretov BSc DipEd (hospital scientist & PhD candidate) Wei Melbourne MSc (hospital scientist) Research Grants NHMRC Program Grant ID No: 535903 Principal investigators Daly RJ, Horvath LG, Millar EKA, Ormandy CJ, Kench JG, O’Toole SA. Project title Molecular markers of phenotype, therapeutic responsiveness and prognosis in human cancers. Total awarded: $11,128,320. 2009-2013. AL.Biomarkers of therapeutic response to tamoxifen in ER+ breast cancer in the context of IBCSG Trials VIII and IX. $50,000. 2010-2012. Illawarra Health and Medical Research Institute small project grant. V Ramachandran, J McArthur, SandersonSmith, R Sluyter, M Lonergan, EKA Millar.Development of an inducible animal model for acute post-streptococcal glomerulonephritis. Total awarded: $10,000. 2012. Original Peer-Reviewed Publications 2012 Coates AS, Millar EKA, O’Toole S, Musgrove E, Viale G, Regan M, Goldhirsch A, Gelber RD, Price KN, CastiglioneGertsch M, Sutherland RL. Qualitative prognostic interaction between immunohistochemical expression of p53 and estrogen receptor in patients with node-negative breast cancer. Results from International Breast Cancer Study Group Trials 8 and 9. Breast Cancer Res. 2012 Nov 5;14(6):R143. Chow HT, Tran K, Millar EKA, Lynch J, Murrell DM. Diverse presentations of carcinoma erysipelatoides. Case reports in dermatological medicine 2012:134938. Hao J, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, Chang L, Xiao W, Cozzi PJ, Graham PH, Kearsley JH, Li Y. In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147. PLoS One. 2012;7(8) Cancer Australia Project Grant 626201 Investigators: Graham PH, Delaney G, Millar EKA, Capp A. A Randomised comparison of anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent antioestrogen therapy delayed until after radiotherapy (STARS - Study of Anastrozole and Radiotherapy Sequencing), $660,000. 2010-2012. Wei Melbourne, Kim Tran , Loreena Johnson , Paul de Souza , William J. Lynch. hENT1 expression in human urothelium; Evaluating hENT1 prognostic potential for intravesical Gemcitabine treatment come in patients with superficial urothelial carcinoma. BJUI, vol 109, supple 4 April 2012. Cancer Institute NSW Translational Program Grant 10/ TPG/1-04. Investigators: Horvath L, Kench J, Boyer M, Millar E, O’Toole S, Beith J and Grimison P. Personalised medicine for cancer: molecular biomarkers in clinical decision making for breast, prostate and pancreatic cancer. $3,714,000. 2010-2014. O’Toole, Beith J, Millar EKA, West R, McLean A, Cazet A, Swarbrick A, Oakes S. New therapeutic targets in triple negative breast cancer. Journal of Clinical Pathology. 2013. 66(6):530-42. ANZ Breast Cancer Trials Group. Investigators: Sutherland RL, O’Toole SA, Millar EKA, Musgrove EA, Coates 2013 C Wolford, M Leon, A Merchant, X Yin, S Jalgaonkar, Y Seok Chang, J Dominick, S McConoughey, E Zmuda, SA O’Toole, EKA Millar, CL Shapiro, M Ostrowski, RL Sutherland, T Hai. ATF3 links host adaptive-response 137 to breast cancer metastasis. J Clin Invest. 2013 Jul 1;123(7):2893-906. Urothelial Carcinoma – A translational study of potential predictive biomarkers, MSc Thesis (UNSW). Browne BC, Hochgräfe F, Wu J, Millar EK, Barraclough J, Stone A, McCloy RA, Lee CS, Roberts C, Ali NA, Boulghourjian A, Schmich F, Linding R, Farrow L, Gee JM, Nicholson RI, O’Toole SA, Sutherland RL, Musgrove EA, Butt AJ, Daly RJ. Global characterization of signalling networks associated with tamoxifen resistance in breast cancer. FEBS J. 2013 280(21):5237-57. Presentations at Scientific Meetings and Conferences Tiu A, Reynolds R, Millar EKA, Aslan P. Neuroblastoma of the adult kidney, the report of a case. Urology. 2013 Jul;82(1):11-3. Hau E, Browne L, Capp A, Delaney G, Fox C, Kearsley JH, Millar EKA, Nassar EH, Papadatos G, Graham PH: The impact of breast cosmetic and functional outcomes on quality of life: long term results from the St George and Wollongong Randomized Breast Boost Trial. Breast Cancer Res Treat. 2013;139(1):115-23. Schade B, Lesurf R, Sanguin-Gendreau V , Millar EKA, Zardawi SJ, Lopez-Knowles E, Sutherland RL, O’Toole SA, Kahn M, Hallett M, Muller WJ. Targeting B-catenin signaling in ErbB2-driven breast cancer impairs metastasis and expression of ErbB2. Cancer Res. 2013; 15:73(14):4474-87. Ni J, Cozzi P, Hao J, Beretov J, Chang L, Duan W, Shigdar S, Delprado W, Graham P, Bucci J, Kearsley J, Li Y. Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway. Int J Biochem Cell Biol. 2013 Dec;45(12):2736-48. Venugopal SS1, Yan W, Frew JW, Cohn HI, Rhodes LM, Tran K, Melbourne W, Nelson JA, Sturm M, Fogarty J, Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell DF. A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol. 2013 Dec;69(6):898-908.e7. doi: 10.1016/j.jaad.2013.08.014. Epub 2013 Sep 24. Other Published Material EKA Millar, Studies on biomarker development in breast cancer. MD Thesis (UNSW). Wei Melbourne, Immunohistochemistry of Superficial 138 2012 - International EKA Millar, Intrinsic subtype and its clinical significance in early node negative breast cancer: results from two randomized trials of adjuvant chemoendocrine therapy. American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, USA, June. EKA Millar, Sydney International Breast Cancer Conference 2012: “Basal-like breast cancer”. Sydney, October 24-26. 2012 - National Wei Melbourne, Kim Tran, Loreena Johnson, Paul de Souza, William J. Lynch. hENT1 expression in human urothelium; Evaluating hENT1 prognostic potential for intravesical Gemcitabine treatment come in patients with superficial urothelial carcinoma 65Th Annual Scientific meeting Darwin April. 2013 - International Wei Melbourne, Kim Tran, Dedee F. Murrell. Collagen VII monoclonal antibodies in the diagnosis of dystrophic epidermolysis bullosa by immunofluorescence mapping. Beijing China BIT’s 5th Annual Internation Congress of Antibodies (ICA-2013). Cohn HI; Tran K; Chow CW; Palmer E; Turner A; South AP; Murrell DF, 2013, ‘A novel mutation in COL7A1, G2269R causing nail only DDEB and RDEB, with a presentation similar to TBDN at birth when coinherited with R2814X COL7A1 mutation’, in Journal of investigative dermatology, NATURE PUBLISHING GROUP, pp. S141 - S141, presented at International Investigative Dermatology Meeting, Edinburgh, Scotland, 8 - 11 May. Yan WF; Venugopal SS; Frew JW; Rhodes LM; Melbourne W; Tran K; Murrell DF, 2013, ‘Translocation of the cytokine HMGB1 coincides with wound healing in fibroblastinjected wounds of recessive dystrophic epidermolysis bullosa’, in Journal Of Investigative Dermatology, Nature Publishing Group, pp. S137 - S137, presented at International Investigative Dermatology Meeting, Edinburgh, Scotland, 8 - 11 May. AGED AND EXTENDED CARE Aged Care, St George Hospital > 140 Rehabilitation Medicine, > St George Hospital 141 Southcare, The Sutherland Hospital > 142 > Department of Aged Care St George Hospital Head of Department Research Grants Peter Smerdely MBBS (Hons) MPH PhD FRACP Senior Staff Specialist Geriatric Medicine & Endocrinology Director Department of Aged Care, St George Hospital Co Director, Aged & Extended Care, St George and Sutherland Hospitals Health Service, Network Executive Clinical Director, Conjoint Associate Professor UNSW St George & Sutherland Medical Research Foundation. The Impact of Routine Post-Discharge Medical Evaluations of Nursing Home Patients Following Acute Hospital Admissions. Chief Investigator Dr Nicholas Cordato. $50,000, 2012. Senior Medical, Geriatric Medicine Litsa Morfis, MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint Lecturer, UNSW Chris Dedousis, MBBS FRACP Senior Staff Specialist, Geriatric Medicine & Thoracic Medicine Conjoint Appointment with Southcare, Sutherland Hospital, Conjoint Senior Lecturer, UNSW Sarah Baldwin MBBS FRACP Staff Specialist, Geriatric Medicine, Conjoint Lecturer, UNSW Tony Youssef BSc (MED) MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint Appointment with Southcare, Sutherland Hospital Nicholas Cordato, MBBS (Hons 1) FRACP PhD Senior Staff Specialist, Geriatric Medicine Conjoint Appointment with CRAGS, Calvary Hospital, Conjoint Senior Lecturer, UNSW, Grant Pickard MBChB FRACP Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit Yun Xu MBBS FRACP Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit Conjoint appointment with CRAGS, Calvary Hospital Louise Baird MBBS FRACP Conjoint Lecturer, UNSW Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit & Aged Care Kannie Chuang MBBS FRACP Staff Specialist, Geriatric Medicine Appointed to General Medicine Unit 140 Research Projects in Progress The Impact of Routine Post-Discharge Medical Evaluations of Nursing Home Patients Following Acute Hospital Admissions. Chief Investigator Dr Nicholas Cordato. The 4AT Study: Screening for Delirium in an Elderly Hospital Population. Dr Jayita De, Dr Anne Wand, Professor Peter Smerdely Presentations at Scientific Meetings and Conferences Cordato, N. Invited Platform Presentation. The Extrapyramidal Spectrum. Australian and New Zealand Society for Geriatric Medicine ANZSGM Annual Scientific Meeting 2012, Sydney. Community Engagement All staff members are actively involved with the community. Regular lectures are given to groups auspiced by Alzheimer’s Australia, Department of health and St George Hospital. “Delirium Care: What You Need to Know”, Flip Chart Staff Educational Resource. Developed collaboratively with Associate Professor Victoria Traynor, the University of Wollongong. Peter Smerdely - Member, SESLHD Board. Nicholas Cordato - Senior Research Fellow, Neurosciences Research Australia, Randwick. > Department of Rehabilitation Medicine St George Hospital Head of Department Research Projects in Progress Dr John Estell MBBS, BS, MSpMed, FAFRM(RACP) Cost Benefit of Rehabilitation Care John Estell and Kenneth Chan. Senior Medical Dr Scott Hannan MBBS, BMedSci, FAFRM(RACP) FACRM Conjoint Senior Lecturer UNSW Dr Kenneth Chan MBBS, BSc(Med) FAFRM(RACP) Dr Brenda Slee MBBS MPH FAFRM(RACP) A/Professor Andrew Cole MBBS(Hons) FAFRM(RACP) FACRM Conjoint Associate Professor, School of Community Medicine UNSW On-Site versus Off-site Rehabilitation in Stroke John Estell. On-Site versus Off-site Rehabilitation in Orthopaedic Conditions, John Estell. Interventional Spasticity Management Scott Hannan, Brenda Slee and John Estell. Rehabilitation Intensity of Therapy John Estell. Acute Rehabilitation Intervention in Trauma (multicentre study coordinated through St Vincent’s Hospital) John Estell. Original Peer-Reviewed Publications Poulos, CJ., Eagar, K., Faux, SG., Estell, JJ & Crotty, M. (2013). Subacute care funding in the firing line. Medical Journal of Australia, 199 (2), 92-93. Presentations at Scientific Meetings/ Conferences 2013 International John Estell, Justine Tinker. Best Practice Learning – the Australian Experience, Regional Spasticity Education Conference Seoul Korea, June. John Estell, Spasticity Management and its Impact on Function. Excellence in Spasticity Management, AsiaPacific Conference. Seoul, South Korea, June. 2013 National John Estell, Sub Acute Models of Care, Australasian Faculty of Rehabilitative Medicine Conference, Sydney. Kenneth Chan, On-site vs Off-site Stroke Rehabilitation – which is more cost effective, Australasian Faculty of Rehabilitative Medicine Conference, Sydney. 141 > Southcare, Sutherland Hospital and Community Services Head of Department A/Prof Peter Gonski MBBS BMedSci FRACP conjoint A/Prof UNSW Senior Medical Nyein Nyein Nyi Nyi MBBS FRACP Chris Dedousis MBBS FRACP Stephen Phoon MBBS FRACP Bethlyn Gill MBBS FRACP Philip Conroy MBBS FRACP Lucy Ramon MBBS FAFRM (RACP) Shikha Jain MBBS FRACP Tony Youssef BSc(Med) MBBS FRACP Research Staff Ms A.Stewart CNC Research Projects in Progress VAPOUR study- A Controlled Trial of Vertebroplasty for Acute Painful Osteoporotic FractURes. William.Clark, Terry Diamond, Patrick McNeil; Peter Gonski; Peter Smerdely; Glen Schlaphoff; Derek Glenn; John Rouse; Paul Bird; Chris Dedousis. INSPIRED study- Improving Service Provision for Early Onset Dementia. Brian Draper; Henry Brodaty; Adrienne Withall; Prasad Nishtala; John Hodges; Peter Gonski; Clement Loy; Colleen Mckinnon; Julian Trollor ; Perminder Sachdev ; Christopher Poulos; Robert Cumming; Bruce Brew. Rehabilitation Heel Injury Prevention Project Ann Stewart. Original Peer-Reviewed Publications Gonski PN, Moon I. Outcomes of a Behaviour Unit in an Aged care Service Arch Gerontol Geriatr 2012,55:60-65. Gonski P, Ye X. Fractures related to falls in older patients attending an Emergency Department Australasian Journal on Ageing 2013,32 (1):64-66. Presentations at Scientific Meetings and Conferences 2012 National Gonski PN, Why I prescribe medications for dementia. ANZSGM Scientific meeting Sydney. 142 ALLIED HEALTH Nutrition and Dietetics > 144 Occupational Therapy > 146 Physiotherapy > 147 Speech Pathology > 148 143 > Nutrition and Dietetics, St George Hospital Head of Department Janet Bell (BSc, M NutDiet), Honorary Senior Fellow Illawarra Health and Medical Research Institute, School of Medicine, University of Wollongong Dietitians Maria Chan, PhD, (awaiting to be conferred), BSc(Hons) MNutDiet GradDipExSpSc AdvAPD, Senior Renal Dietitian, Conjoint Associate Lecturer - St. George Clinical School, School of Medicine, University of New South Wales Honorary Senior Fellow - Illawarra health and medical Research Institute, School of Medicine, University of Wollongong Avesani CM, Trolonge S, Deleaval P, Baria F, Mafra D, Faxen-Irving G, Chauveau P, Teta D, Kamimura MA, Cuppari L, Chan M, Heimburger O and Fouque D. Physical activity and energy expenditure in haemaodialysis patients: an international survey. Nephrol Dial Transplantation. 2012 Jun;27(6):2430-4. Chan M, Nutrition, diabetes and chronic kidney disease, Australian Diabetes Educator Volume 15 Number 3, August 2012, 17-23. 2013 Rachel Pons, BNutDietet Lauren Reece, BNutDietet Johnson DW, Atai E, Chan M, Phoon RKS, Scott C, Tussaint N, Turner GI, Usherwood T, and Wiggins, K. KHACARI guideline: Early chronic kidney disease: detection, prevention and management. Nephrology 18 (2013) 340–350. Research Projects in Progress Other Published Material Does a dietitian-led nutrition care pathway improve outcomes in patients with liver cirrhosis attending the Liver Clinic at St George Hospital? Harris, D, Rangan, G, Kairaitis, L and Elder, G. Pocket Guide to Basic Clinical Dialysis 2 edition. Authors: Michelle Ryan, Maria Chan and Murielle Ryan. Chapter 2 Nutrition. Publisher, McGraw-Hill Australia PTY LTD. 2012. Principal investigators: Rachel Pons, Lauren Reece, Janet Bell, Amany Zekry. Nutritional Factors and Clinical Outcomes of Patients with End Stage Kidney Disease. Implications for practice from researching the practice framework. Principal investigators: Maria Chan, Prof. John Kelly (UNSW), Prof. Marijka Batterham (UOW), Prof. Linda Tapsell (UOW). Original Peer-Reviewed Publications 2012 Chan M, Kelly J, Batterham M and Tapsell L. Malnutrition (Subjective Global Assessment) Scores and Serum Albumin Levels, but not Body Mass Index Values, at Initiation of Dialysis are Independent Predictors of Mortality: A 10-Year Clinical Cohort Study. J Ren Nutr 2012; 22(6): 547–557. Manning F, Harris K, Duncan R, Walton K, Bracks J, Larby L, Vari L, Jukkola K, Bell J, Chan M and Batterham M. Additional feeding assistance improves the energy and protein intakes of hospitalised elderly patients. A health services evaluation. Appetite 2012, 59(2): 471–477. 144 Workforce recommendations for renal dietitians in Australia and New Zealand, produced by the Australian and New Zealand renal dietitians workforce planning group. Dietitian Association of Australia, 2012. Presentations at Scientific Meetings and Conferences 2012 – International Chan M, Kelly J, Batterham M and Tapsell L. Nutritional characteristics and dietary intake of patients attending the pre-dialysis assessment clinic. Proceedings of the 16th International Congress of Nutrition and Metabolism in Renal Disease (ICNMRD), June, 2012 (Honolulu, Hawaii). (Poster). Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and intake adequacy in patients with non-dialysis chronic kidney disease. Proceedings of the 16th ICNMRD, June, 2012 (Honolulu, Hawaii). 2013 - International Patwardhan A, Ryan C and Chan M, (workshop leader), Evidence and Practice Guidelines for the Nutritional Management of Adult Kidney Transplant Recipients. 16th International Congress of Dietetics (Sydney, Australia). Chan M, Patwardhan A, Lambert K, and Crosby C (workshop leader). Evidence and practice guidelines for the nutritional management of people with chronic kidney disease stages 1–3, early to moderate renal insufficiency (GFR 30–90 mL/min/1.73m2). 16th International Congress of Dietetics (Sydney, Australia). Janet Bell Home Enteral Nutrition Co Chair, Agency for Clinical Information. 2013 National Chan, M. Invited lecture; Nutritional factors affecting clinical outcomes of patients with End stage kidney disease. The Australasian Society for Parenteral and Enteral Nutrition (AuSPEN), Annual Scientific Meeting, Sydney, November, 2013. Chan M, Kelly J, Batterham M and Tapsell L. Nutritional characteristics and dietary intake of patients at enrolment to the pre-dialysis assessment clinic. Dietitians Association of Australia 30th National Conference, May. Canberra, Australia. Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and adequacy of energy and protein intakes in patients with non-dialysis chronic kidney disease, Dietitians Association of Australia 30th National Conference, May, Canberra, Australia. Chan M, Kelly J, Batterham M and Tapsell L.Nutritional status is associated with the future treatment choice - renal replacement therapy vs. conservative care in end stage kidney disease patients attending the multidisciplinary pre-dialysis assessment clinic. Australian and New Zealand Society of Nephrology, Brisbane, Australia. Community Engagement Maria Chan Allied Health Representative, Ministry of Health - Renal Plan Reference Group for 2013 to 2022 Allied Health Representative, ACI, Renal Service Network (RSN) Executive Committee, NSW Health Allied Health Representative, ACI, Renal Service Network (RSN) Transplant sub-committee, NSW Health. 145 > Occupational Therapy, St George Hospital Head of Department Sharryn Fitzgerald B.App.Sc (OT) Research Staff Ms Pamela Maryse Arndt BAppSc(OT) Mr Glenn Paull RN BN(Honours) Master of Nursing Presentations at Scientific Meetings and Conferences 2013 National Arndt PM, Paull G. Living Well with Heart Failure: a role for Occupational Therapy in the management of chronic heart failure. Australian Cardiovascular Health & Rehabilitation Association Annual Scientific Meeting – Melbourne. Oral presentation selected for the clinical prize session 146 > Physiotherapy , St George Hospital Head of Department Jason Phillips, B.App.Sc (Physio) SGSHHS Sector head Physiotherapy Susan Sellars, B.App.Sc (Physio) St George Hospital Physiotherapy Unit Head Senior Physiotherapists Wendy Hayes, APA, M. Continence and Women’s Health, PGCert Pelvic Floor Rehab, Dip Physiotherapy, Women’s Health Senior Physiotherapist, Conjoint Lecturer UNSW. Wendy Chaseling, APA M.Hlth.Sc (cardiopul. physio, USyd), M.Ed (UNSW) , B.App.Sc (physio., USyd) ICU Senior Physiotherapist, Cardiorespiratory Physiotherapist. Research Grants NHMRC TEAM study: Carol Hodgson, Chief Investigator (The Alfred Hospital, Melbourne), Sue Berney, Rinaldo Bellomo, Linda Denehy, Megan Harrold, Lisa Higgins, Jeff Presnell, Dr Manoj Saxena (St George Hospital), Elizabeth Skinner, Steve Webb, Paul Young, Heidi Buhr Site Investigator: Wendy Chaseling, Physiotherapist St George Hospital Presentations at Scientific Meetings and Conferences 2012 - International Hayes, W. A prospective Randomised Controlled Trial Comparing pelvic Floor Treatments by a Pelvic Floor Physiotherapist Versus Extracorporeal magnetic Stimulation. The RCT compared treatments for women with Stress Urinary Incontinence. International Urogynaecology Association Conference, Brisbane, November. (Podium Presentation and Poster). Community Engagement Wendy Chaseling Chair of Working Party for Agency for Clinical Innovation– Intensive Care Co-Ordination and Monitoring Unit Best Practice Guideline for Suctioning. Systematic Review conducted. Clinical Practice Guidelines for all clinical disciplines (including Medical, Physiotherapy and Nursing) written and published: http://intensivecare.hsnet.nsw.gov. au/icwiki/index.php/Suction TEAM (Trial of Early Activity and Mobility in Intensive Care) $45,000: 2011-2013 Research Projects in Progress TEAM study: Observational study to review the current practice of patient mobility in 25 Intensive Care Units across Australia and New Zealand, to determine barriers to mobility and what type of activities are undertaken by ICU patients. Principal investigators (as above) Site Investigator: Wendy Chaseling, Physiotherapist St George Hospital Other Published Material Harris, D, Rangan, G, Kairaitis, L and Elder, G. Pocket Guide to Basic Clinical Dialysis 2 edition. Authors: Michelle Ryan, Maria Chan and Murielle Ryan. Chapter 2 Nutrition. Publisher, McGraw-Hill Australia PTY LTD. 2012. Workforce recommendations for renal dietitians in Australia and New Zealand, produced by the Australian and New Zealand renal dietitians workforce planning group. Dietitian Association of Australia, 2012. 147 > Speech Pathology Head of Department Tracy Kelly, B.App.Sc (Speech Pathology) Senior Speech Pathologists Julia Maclean, PhD; M.Sc. (Medicine); B.App.Sc (Speech Pathology) Wendy Relf, M.HealthSc. (Communications), B.App.Sc (Speech Pathology), BA (Linguistics/Psych) Research Grants NHMRC Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy. Prof Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean, A/Prof Peter Graham, Dr Taher Omari. $301,624 (2012-2014). Research Projects in Progress Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck . radiotherapy. Prof Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean, A/Prof Peter Graham, Dr Taher Omari. (Women’s and Children’s Health, Adelaide). Prospective, randomized controlled trial of cricopharyngeal dilatation in post-laryngectomy dysphagia. Dr Peter Wu, Prof Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean. Influence of Altered Pharyngo-esophageal Biomechanical Parameters on Swallowing and Speech Function in Laryngectomees. Ms Teng Zhang Professor Ian Cook, Dr Michal Szczesniak, A/Prof Paul Bertrand (UNSW), Dr Julia Maclean. Original Peer-Reviewed Publications Krishnan, S. and Maclean J (2013). Practice of laryngectomy rehabilitation interventions: a perspective from Australia. Current Opinion in Otolaryngology and Head and Neck Surgery 21(3):224-229. Other Published Material Perry, A. and Maclean, J. (2012) Rehabilitation after Treatment for Recurrent Head and Neck Cancer. In H. Mehanna and K. Ang (Eds), Head and Neck Cancer Recurrence: Evidence-based, Multidisciplinary Management (pp. 253-259). Germany: Thieme. 148 Maclean, J – Co-Author - ACI - Care of adult patients in acute care facilities with a tracheostomy – Clinical Practice Guideline 2013. Maclean, J – Co-Author - Speech Pathology Australia Clinical Guideline – Laryngectomy Management 2012. Presentations at Scientific Meetings and Conferences 2012 - International Maclean, J.C., Szczesniak M, Zhang, T, Graham, P, Cook IJ. - Dysphagia Research Society, Toronto, USA, March 2012. Dysphagia is a prevalent and under-recognized complication of head and neck radiotherapy. Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, Oesophageal dysmotility in laryngectomy patients: An unrecognized association. 2012 - National Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, Oesophageal dysmotility in laryngectomy patients: An unrecognized association. Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, Long-term dysphagia following Radiotherapy. Maclean, J.C., Australian and New Zealand Head and Neck Cancer Society, Brisbane, October, 2012, invited panellist IFHNOS Session 3: Multidisciplinary Therapy. 2013 - International Maclean, J.C., Ward EC., Findlay M, Rees G Dysphagia Research Society, Seattle, USA, March 2013. Dysphagia and nutritional management in Australian and New Zealand head and neck cancer centres. 2013 - National Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Society, Melbourne, September, 2013, Cricopharyngeal dysfunction – assessment and treatment. Community Engagement Julia Maclean Executive member – Australian and New Zealand Head and Neck Cancer Research Foundation Executive Australian and New Zealand Head and Neck Cancer Society. Wendy Relf Representative - ACI/Stroke Services NSW 149 ERRATUM In the 2010-11 Research Report, the following report from Mental Health was inadvertently cut during the printing process. The full version of the report appears below. 1. Department title – Mental Health Unit, Mental Health Academic Unit / School of Psychiatry 2. Departmental Staff* Dr Margot Phillips BABSc (Med) MBBS FRANZCP Vocational registrars, advanced trainees Dr Roslyn Lai (MBBS, MD) - 2011 Senior research staff Dr Angelo Alonzo (BA, BSc (Hons), Ph.D) Dr Donel Martin (MClinNeuroPsych; PhD), BA (Hons); MClinNeuroPsy Head of Department Dr Kevin Clarke MBBS(Hons), MHA, Grad Dip FBS, FRANZCP Research assistants Conjoint Lecturer UNSW Professor Colleen Loo (MB.BS. (Hons), FRANZCP, MD.; Professor – School of Psychiatry UNSW; Michael Player (BPsych (Hons), Ph.D) Varsha Sivalingham (ILP) Rose Liu (ILP) Natalie Johnston (BSc, MB BS) Research Psychiatrist – Black Dog Institute) Nursing & Allied Health research staff Dr Matthew Boulton BMBS BSc FRANZCP Psychiatrist – PECC Conjoint Associate Lecturer UNSW Dr Grace Chan (BA Nursing), PhD) Dr Anne Camac MBBS, FRANZCP Conjoint Lecturer UNSW Dr Mesut Cetiner MBBS Bsc (Med) (Hons) FRANZCP Certificate POA & Conjoint Lecturer UNSW Dr Denise Cupina MD, FRANZCP Conjoint Senior Lecturer UNSW Dr Spencer Duke BMedSci BM BS MRCPsych FRANZCP Conjoint Senior Lecturer UNSW Dr Andrew Gerard MBBS FRANZCP Dr Peter Jones MBChB MRCPsych FRANZCP Dr Andrew Kaill BMED FRANZCP TA Dr Yana Kay MBBS, BA, PHD FRANZCP Conjoint Lecturer UNSW Dr Andrew Pethebridge MBBS, MM (Ven Sci), MM, FRANZCP, FAChAM Conjoint Senior Lecturer UNSW Natalie Katalinic (BA (Hons) Research students 3. Research Grants# Category I - Nationally Competitive Grants NHMRC Project Grant ID 510142 - A Sham-controlled Study of Transcranial Direct Current Stimulation (tDCS) as a Treatment for Depression. Professor Colleen Loo $400,500 (2008-2010) NHMRC Project Grant ID 568678 - A controlled study of bilateral electroconvulsive therapy Professor Colleen Loo, Professor Isaac Schweitzer $421,268 (2009-2011) NHMRC Project Grant ID 1004152 – Role of neurogenesis in clinical recovery from depression during ECT: Application of a novel in vivo magnetic resonance spectroscopy technology. Dr Michael Valenzuela, Professor Colleen Loo, Dr Jesus Pujol, Professor Petar Djuric, Dr Dennis Velakoulis, Associate Professor Murat Yucel, Professor Mike Dragunow $505,312 (2011-2013) NARSAD young Investigator Award – Remediation of cognitive dysfunction in euthymic bipolar disorder patients using transcranial direct current stimulation (tDCS) Dr Donel Martin $60,000 USD (2011-2012) Category II - Other competitive grants Category III – Industry and other research funding: UNSW Gold Star Award. Outcomes of Standard and 151 Ultrabrief Pulsewidth ECT. Professor Colleen Loo $40000 (2010) Genetic Factors, Biomarkers and Outcomes of Brain Stimulation Professor Colleen Loo UNSW Gold Star Award. A comparative study of two forms of ECT: standard and ultrabrief pulsewidth. Professor Colleen Loo $40000 (2011) A study of transcranial electrical stimulation Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Sachdev, Dr Donel Martin, Dr Angelo Alonzo UNSW Gold Star Award. A controlled trial of ketamine as an adjunctive agent in ECT. Professor Colleen Loo $40000 (2011) UNSW Early Career Faculty Research Grant – The effect of timing of transcranial direct current stimulation (tDCS) for enhancing learning during cognitive training. Dr Donel Martin $17,000 (2011) 4. Research Projects in Progress A controlled study of ultrabrief pulsewidth ECT Professor Colleen Loo, Professor Isaac Schweitzer An effectiveness trial assessing the efficacy and cognitive side effects of BT, BF and RUL ECT Professor Colleen Loo, Dr Bill Lyndon A double-blind, randomised, placebo-controlled study of adjunctive ketamine anaesthesia in ECT (electroconvulsive therapy) Professor Colleen Loo, Associate Professor Ross MacPherson, Dr Ron Woodey, Dr Bill Lyndon Validation of a new in vivo MRI approach for measurement of hippocampal neurogenesis in humans Dr Michael Valenzuela, Professor Colleen Loo Genetic factors, biomarkers, and outcomes in ECT Professor Colleen Loo A sham-controlled study of transcranial direct current stimulation (tDCS) as a treatment for depression Professor Colleen Loo, Professor Philip Mitchell, Professor Perminder Sachdev, Melissa Pigot Open pilot trial of transcranial direct current stimulation (tDCS) using alternative electrode montages. Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Sachev, Dr Donel Martin, Dr Angelo Alonzo Investigating methods to enhance the excitatory effects of transcranial direct current stimulation (tDCS). Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Sachev, Dr Donel Martin, Dr Angelo Alonzo Comparison of measures of plasticity Professor Colleen Loo, A/Prof Janet Taylor, Prof Perminder Sachev, Michael Player 152 A study of ketamine as an antidepressant Professor Colleen Loo, Dr John Leyden, Dr Simon Harper, Dr Jenny McGoldrick, Dr Jarrett Johnston, Dr Harry Wark, Natalie Katalinic, Dr Grace Chan Open Pilot Trial of Temporal Lobe Transcranial Direct Current Stimulation (tDCS) for Depression Professor Colleen Loo, Dr Angelo Alonzo, Dr Donel Martin Investigating Direct current Stimulation as a Treatment for Depression: A Controlled Clinical Trial Professor Colleen Loo, Professor Philip Mitchell, Professor Perminder Sachdev, Dr Angelo Alonzo, Dr Donel Martin Enhancing cognitive training using transcranial direct current stimulation (tDCS): a randomised controlled trial. Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Enhancing Learning During Cognitive Training Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green, Dr Angelo Alonzo Remediation of Cognitive Dysfunction in Euthymic Bipolar Disorder Patients Using Transcranial Direct Current Stimulation (tDCS): A pilot study Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green, Professor Philip Mitchell, Dr Angelo Alonzo Neuroplasticity induced by transcranial direct current stimulation treatment. Professor Colleen Loo, Dr Janet Taylor, Michael Player 5. Original Peer-Reviewed Publications Loo C, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi G, Lagopoulos J, & Mitchell P. A double-blind, shamcontrolled trial of transcranial direct current stimulation for the treatment of depression. International Journal of Neuropsychopharmacology 2010; 13:61-69. O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z, McDonald WM, Avery D, Fitzgerald PB, Loo C, Demitrack MA, George MS, Sackeim HA. Reply Regarding “Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial”. Biological Psychiatry 2010; 67:e15-e17. Arul-Anandam A, Loo CK & Mitchell P. Induction of hypomanic episode with transcranial direct current stimulation. Journal of ECT 2010; 26:68-69. Disorders, 2011; 132: 1-13. Loo C, Sainsbury K, Mitchell P, Hadzi-Pavlovic D, Sachdev P. A Sham-Controlled Trial of Left and Right Temporal rTMS for the Treatment of Auditory Hallucinations. Psychological Medicine 2010; 40(4):541-546. Loo C, Martin D, Alonzo A, Gandevia S, Mitchell P, Sachdev P. Avoiding Skin Burns with Transcranial Direct Current Stimulation: Preliminary Considerations. International Journal of Neuropsychopharmacology, 2011;14(3):425-6. Loo C, Kaill A, Paton P, Simpson B. The Difficult-toTreat Electroconvulsive Therapy Patient - Strategies for Augmenting Outcomes. Journal of Affective Disorders 2010; 124(3):219-227. Matheson S, Green M, Loo C & Carr V. Quality assessment and comparison of evidence for electroconvulsive therapy and repetitive transcranial magnetic stimulation for schizophrenia: a systematic meta-review. Schizophrenia Research 2010; 118(1-3): 201-210). MacPherson R, Lawford J, Simpson B, Mahon M, Scott D and Loo CK. Low dose lignocaine added to propofol does not attenuate the response to electroconvulsive Therapy. Journal of Affective Disorders, 2010; 126(1-2): 330-3. Loo CK, Simpson B, MacPherson R. Augmentation Strategies in Electroconvulsive Therapy. Journal of ECT 2010; 26: 202-207. Matheson S, Green M, Loo C & Carr V. A change in the conclusions of a recent systematic meta-review: repetitive transcranial magnetic stimulation is effective for the negative symptoms of schizophrenia. Schizophrenia Research, 2010; 122 (1-3): 276-277. Haskett R & Loo C. Role of Adjunctive Psychotropic Medications during ECT in the Treatment of Depression, Mania and Schizophrenia. J ECT 2010; 26:196-201. Loo C, Kayess R, Alonzo A, Rendina N, Trollor J. Mental Health Legislation & Psychiatric Treatments in NSW: Electroconvulsive Therapy and Deep Brain Stimulation. Australasian Psychiatry, 2010; 18(5): 417-425. Janicak, P, Nahas Z, Lisanby S, Solvason HB, Sampson S, McDonald W, Marangell L, Rosenquist P, McCall V, Kimball J, O’Reardon J, Loo C, Husain M, Krystal A, Gilmer W, Dowd S, Demitrack M, Schatzberg A.4Durability of Clinical Benefit With Transcranial Magnetic Stimulation (TMS) in the Treatment of Pharmacoresistant Major Depression: Assessment of Relapse During a Six-Month, Multisite, Open-Label Study. Brain Stimulation, 2010; 3(4): 187-199. Ehnvall A, Mitchell P, Hadzi-Pavlovic D, Loo C, Breakspear M, Wright A, Roberts G, Frankland A, Corry J. Pain and rejection sensitivity in bipolar depression. Bipolar Disorders, 2011; 13(1): 59-66. Loo C, Katalinic N, Mitchell P, Greenberg B. Physical Treatments for Bipolar Disorder: A Review of Electroconvulsive therapy, Stereotactic Surgery and other Brain Stimulation Techniques. Journal of Affective Loo C, Mahon M, Katalinic N, Lyndon B, Hadzi-Pavlovic D. Predictors of Response to Ultrabrief Right Unilateral Electroconvulsive Therapy. Journal of Affective Disorders 2011; 130: 192-197. Galvez V, Alonzo A, Martin D, Mitchell P, Sachdev P, Loo C. Hypomania induction in a bipolar II patient with transcranial Direct Current Stimulation (tDCS). Journal of ECT 2011; 27(3):256-258. Stewart P, Loo C, MacPherson R, Hadzi-Pavlovic D. The Effect of Electrode Placement and Pulse Width on Asystole and Bradycardia during the Electroconvulsive Therapy Stimulus. International Journal of Neuropsychopharmacology 2011; 14(5):585-94. Rushby J, Vercammen A, Loo C, Short B, Weickert C, Weickert T. Frontal versus parietal contributions to probabilistic association learning. Cerebral Cortex 2011; 21(8):1879-1888. Mitchell P, Frankland A, Hadzi-Pavlovic D, Roberts G, Corry J, Wright A, Loo C, Breakspear M. A comparison of depressive episodes in bipolar disorder and major depressive disorder within bipolar disorder pedigrees. British J Psychiatry 2011; 199: 303-309. Doi 10.1192/bjp. bp.110.088823 Alonzo A, Brassil J, Taylor J, Martin D, Loo C. Daily transcranial Direct Current Stimulation (tDCS) leads to greater increases in cortical excitability than second daily tDCS. Brain Stimulation 2011, doi:10.1016/j. brs.2011.04.006. Martin D, Alonzo A, Mitchell P, Sachdev P, Galvez V, Loo C. Fronto-extracephalic transcranial direct current stimulation as a treatment for major depression: An open-label pilot study. Journal of Affective Disorders 2011; 134(1-3):459463. Vercammen A, Rushby J, Loo C, Short B, Weickert C, Weickert T. Transcranial Direct Current Stimulation (tDCS) influences probabilistic association learning in people with schizophrenia. Schizophrenia Research 2011; 131(1-3):198205. Bai S, Loo C, Dokos S. A computational model of direct brain excitation induced by electroconvulsive therapy: comparison among three conventional electrode placements. Brain Stimulation. doi:10.1016/j. brs.2011.07.004 153 6. Other published material (Books, book chapters, reviews,) ECT”. NSW Health ECT conference, March 25-26, 2010. Sydney Walter G, Rey J, Ghaziudding N, Loo C. Electroconvulsive Therapy, Transcranial Magnetic Stimulation and Vagus Nerve Stimulation (chapter). In: Martin A, Scahill L, Kratcochvil C (Editors). Pediatric Psychopharmacology: Principles and Practice, Second Edition (pp. 363-373). New York: Oxford University Press, 2010. Invited Lecture “Principles of Brain Stimulation”. NSW RANZCP Advanced Trainees Program. Sydney, 24 June, 2010. Loo C, Greenberg B, Mitchell P. Non-pharmacotherapeutic Somatic Treatments for Bipolar Disorder (ECT, DBS, rTMS) (chapter). In: Manji H & Zarate C (eds) Behavioral Neurobiology of Bipolar Disorder and Its Treatment (pp. 285-302). Springer Verlag, 2011. Mitchell P, Hadzi-Pavlovic D, Loo C. Course and Outcome of Bipolar Disorder (chapter). In: Manji H & Zarate C (eds) Behavioral Neurobiology of Bipolar Disorder and Its Treatment (pp. 1-18). Springer Verlag, 2011. 7. Presentations at Scientific Meetings/ Conferences Loo C, Sainsbury K, Mitchell P, Hadzi-Pavlovic D, Sachdev P. A Sham-controlled Trial of Left and Right Temporal rTMS for the Treatment of Auditory Hallucinations. Australian and NZ Journal of Psychiatry, 2010; 44 (1): A15-16. Weickert T, Rushby J, Vercammen A, Weickert C, Loo C. Effects of Transcranial Direct Current Stimulation on Probabilistic Feedback Learning in People with Schizophrenia. Australian and NZ Journal of Psychiatry, 2010; 44 (1): A16. Rushby JA, Loo C, Weickert CS, Weickert TW. Effects of transcranial direct current stimulation on probabilistic category learning in patients with schizophrenia. Schizophr Res, 2010, 117 (Nos 2-3):177. Mitchell, PB, Frankland, A, Hadzi-Pavlovic, D, Roberts, G, Wright, A, Loo, CK, Malhi & Breakspear, MJ 2010, A comparison of the phenomenology and illness course of major depressive episodes in major depressive disorder and bipolar I and bipolar II disorders, Bipolar Disorders, 2010 Vol. 12 (Suppl. 1) page 38 Mitchell P, Frankland A, Hadzi-Pavlovic D, Roberts G, Wright A, Loo C, Breakspear M. On the nature of major depressive disorder (unipolar depression) in bipolar disorder pedigrees. Int J Neuropsychopharm, 2010; 13: 130-130, Suppl. 1 Weickert T, Gendy R, Chan M, Loo C, Mitchell PB, Weickert CS. Probabilistic association learning impairment predicts degree of schizotypal personality traits. Schizophrenia Bulletin, 2011, 37: 233, Suppl. 1. Invited speaker, “Electrode placement and dosing in 154 Invited Lecturer, NSW Institute of Psychiatry 3rd Yr Trainees, ECT and Brain Stimulation. Sydney 22 July, 2010. Invited main speaker, Ramsay Healthcare Continuing Education Workshop on “ECT and TMS”, Adelaide Clinic, SA, 9 Sept, 2010 Keynote Speaker, Queensland Neuropsychiatry Interest Group 7th Annual ECT Forum, Brisbane. “ECT – Stimulus Parameters”. Brisbane, 16 Oct, 2010. Presentation “tDCS in depression” and Panel Discussant “Physical Treatments of Depression”, Depression Masterclass, hosted by Servier. Sydney 7 Nov, 2010. Plenary Speaker “Synergistic antidepressant effects with ketamine and ECT” Australasian Society for Psychiatric Research, 6-8 Dec, Sydney, 2010 Chair, Early Career Researchers symposium. Australasian Society for Psychiatric Research, 6-8 Dec, Sydney, 2010 Invited speaker, UNSW Brain Sciences Symposium ‘Brain Stimulation”. Topic: Brain stimulation - a tool for treating psychiatric disorders”, Sydney, 15 March, 2011 Invited Speaker, First National Symposium on Translational Psychiatry. Topic: “ECT, TMS and DCS: Established and Emerging Treatments”. Canberra 4-5 April, 2011 Guest Speaker, NSW Health Adult Acute Inpatient Benchmarking Forum. Topic: “ECT”. Sydney, 3 May, 2011. Westmead Hospital Psychiatry Grand Rounds. “Recent Advances in Treatments for Depresssion”. 7 July, 2011 Psychiatry Grand Rounds, St George Hospital. New Treatments in Depression – Ketamine. 4 August, 2011. Psychiatry Grand Rounds, The Sutherland Hospital. New Treatments in depression. 25 August, 2011. Invited symposium speaker, Australian Society of Anaesthetists National Scientific Congress, Sydney, 8 Sept 2011. Strategies for Optimising ECT. St John of God Burwood Grand Rounds. Electroconvulsive Therapy. 2 Sept, 2011 Australiasian Society for Bipolar Disorders Conference. ECT workshop chair & speaker: “Optimising ECT: The importance of stimulus parameters” . Sydney Oct 20-22, 2011 Australiasian Society for Bipolar Disorders Conference. Brain stimulation symposium chair and speaker “Novel Brain stimulation – what is the therapeutic potential?” Sydney Oct 20-22, 2011 Queensland Mental Health symposium: An Update on ECT. Invited speaker “New Brain Stimulation Treatment and ECT”. Brisbane Oct 29, 2011 NSW Mental Health Advocacy Service Training Day. “Electroconvulsive Therapy and NSW Health Guidelines”. 15 November, 2011. Sydney. International Bai S, Loo C, Dokos S. A Computational Model of Direct Brain Stimulation by Electroconvulsive Therapy. Conf Proc IEEE Eng Med Biol Soc. 2010; 1:2069-72. Invited workshop presentation/ Meeting Faculty, International Society for ECT and Neurostimulation. Topic: “Transcranial Direct Current Stimulation for Depression”. Hawaii, 15 May, 2011. 8. Community Engagement “Old Wives Tale: Electroshock treatment is harmful”. Women’s Day, 5 April, 2010 Southern Courier – article on tDCS. June 2010. ECT research quoted in UK paper, Daily Mail, “How short shocks could transform depression.: June 15, 2010. “NSW Restrictions on ECT and DBS “not justifiable” Psychiatry Update Newsletter, 30 Sept, 2010. [Australasian Psychiatry 2010; 18: 417-425 quoted] “Rise and Shine” – interview on ECT. Channel Nine, 2 May, 2010. Channel 10 News – interview on tDCS, 9 June, 2010. Interview for radio 2SER on use of ECT, 25.5.2010. Interview for ABC Radio National, PM program, 8 June, 2010, on tDCS. Interview for ABC Radio National, Mornings with Deborah Cameron, on tDCS trial in depression. 6 April, 2011 Interview for ABC Radio Canberra, on tDCS trial in depression. 6 April, 2011 Interview for ABC Radio Central West, on tDCS trial in depression. 6 April, 2011 Medical Observer – interview re ECT 8.2.2011 Sun Herald, interviewed for article on ECT, 26 June, 2011 155 St George & Sutherland Medical Research Foundation Suite 8, 13 Hogben Street, Kogarah, NSW 2217 Phone 02 9587 0643 Email [email protected] Web www.icareresearch.com.au Please support your local medical research foundation.