Download Diet-Drug Interactions and Absorption (Conti.)

Food and Drug
Interactions
Khalid A. Al-Madani, MPH, DSc
Consultant In Clinical Nutrition & Vice Present
of Saudi Society for Food and Nutrition
Medications and
Food Intake
Drug Complications That
Alter Food Intake
Medications
and Food Intake (Conti.)
Medication That Alter
Appetite
Diet-Drug Interactions
and Absorption
Medication Effects
on Nutrient Absorption
Diet-Drug Interactions
and Absorption (Conti.)
Drug-nutrient binding
Diet-Drug Interactions
and Absorption (Conti.)
Altered acidity in the
stomach
Diet-Drug Interactions
and Absorption (Conti.)
Stomach Emptying Rate
Diet-Drug Interactions
and Metabolism
An increase
in enzyme activity
leads to a decrease
in drug concentration
and effect
AND
A decrease
in enzyme activity
leads to an increase
in drug concentration
and effect
Diet-Drug Interactions
and Metabolism ( Conti.)
Diet-Drug Interactions
and Metabolism ( Conti.)
A New Concern - Grapefruit


Can cause more
of a drug to be
absorbed from
intestine – even
toxic levels
May cause a drug
not to work
Diet-Drug Interactions
and Metabolism ( Conti.)
Diet-Drug Interactions
and Metabolism ( Conti.)
Vitamin K and Warfarin



Keep intake of foods containing Vitamin
K constant
Vitamin K is high in spinach, kale,
cauliflower, broccoli and other leafy
greens
Also don’t take Vitamin K
supplement
Diet-Drug Interactions
and Excretion
Medication Effects on
Nutrient Excretion
Diet-Drug Interactions
and Excretion ( Conti.)
Dietary Effects on
Medication Excretion
Diet-Drug Interactions
and Toxicity
Diet-Drug Interactions
and Toxicity ( Conti.)
MOA Inhibitors



No beer, red wine
No cheddar, brie, mozzarella
cheese
No beef or chicken liver, cured
meats, caviar or dried fish
Diet-Drug Interactions
and Toxicity ( Conti.)
Conclusion
Clinicians often overlook or
fail to recognize diet-drug
interactions, yet such
interactions can raise health
care costs and result in
serious, and sometimes fatal,
complications. With hundreds
of diet-drug interactions
known and more to be
identified in the future, health
care professionals must learn
to take steps to prevent them.
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