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BIOL 103 Introductory Biology of Organisms Winter2017 CALENDARDESCRIPTION Anintroductiontothebasicthemesandconceptsofmodernbiologyspanningorganizationallevelsfrom organismstoecosystemsinanevolutionarycontext. SCHEDULE LectureSection1(DuncanMacArthur)–Monday10:30,Wednesday9:30,Friday8:30. LectureSection2(BioSciAud)–Monday1:30,Wednesday12:30,Friday11:30. LectureSection3(HumphreyAud)–Monday4:30,Wednesday3:30,Friday2:30. Labs:SeeSOLUSforalistofvariouslabtimesandlocations CONTACTINFO Instructors ProfsVirginiaWalkerandAdamChippindale InstructorContact Dr.Walker,Rm.2522BioSci [email protected],ph:613-533-6123 Dr.Chippindale(coursecoordinator),2420BioSci [email protected],ph:613-533-6139 OfficeHours TBA LabInstructor RobSnetsinger([email protected]) LabInstructorContactInfo Ph:613-533-6000ext77439, Rm.2322ABioscience Rob’sOfficeHours Normally,9:30-11:30and1:30-3:30Mondayto Friday LearningObjectives Justaseukaryoticcellsarecomplexandintegratedmachines,organismsarebuiltaroundthespecialization ofcellsintotissuesandorgansthatgrow,differentiateandcommunicateinordertocompeteandachieve reproductivesuccessasanintegratedunit.Biology103developsasolidunderstandingofhowananimalis builtandinteractswiththeabioticandbioticenvironment;howitstissuesandorgansworktogetherto maintainasteadystateoradaptinthefaceofchallengesfromstressandinfection.Evolutioniskeyto understandingboththehistoryoflifeandorganismalfunction,andtheBiologyofOrganismsissteepedin evolutionaryprinciplesateachlevelofbiologicalorganization,includingtheforcesthatdrivechangeingene frequencieswithinpopulations.Finally,recognizinghowpopulationsofdifferentspeciesinteractin communitiesandecosystemsisvitaltounderstandingandprotectingbioticdiversityfromlocaltoglobal scales.Thus,althoughBiology103istitledIntroductoryBiologyofOrganisms,understandingtheorganism requireszoominginandoutfromgenestoecosystems,andtravellingbackintimesowemaypredictthe future. LearningHours 2 Other In-classhours Thetableoflearninghoursisonlyaroughestimateofthetimerequiredforthecourse.A3.0unitcourse wouldnormallyrequireatotalof110to130totallearninghoursandthiscoursewillfallwithinthatrange, butofcourse,isdependentuponindividualvariation. Teachingmethod Averagehoursper Numberofweeks Totalhours week Lecture 3 12 36 Seminar Laboratory 2 12 24 Tutorial Practicum Grouplearning Individualinstruction Onlineactivity 2 12 24 Off-campusactivity Privatestudy 3 13 39 Totalhoursontask 123 CourseOutline A. 1. 2. 3. 4. 5. TheMakingofOrganismsfromCells(Dr.Walker) (Duration:thefirst6weeksoflectures;18lecturestotal) IntracellularandExtracellularDigestion Ageneralintroductiontothecourse,guidelines,expectationsandlabannouncementswillbemade. Inaddition,intracellularandextracellulardigestionwillbeexaminedwithexamplesfromprotists, fungiandmorecomplexmetazoans. DigestionandAbsorption Enzymesimportantfordigestionwillbeexplored,aswellasthespecificityofactionofselected proteases,withmostexamplesfromhumans. DigestionandProblems Thediscussionofdigestiveenzymeswillbecontinued,andsomehumandiseasesassociatedwith digestionwillbeexplored. ExcretionandIonTransportI Thenitrogenouswasteproblemwillbepresentedusingexamplesfromfish,insects,developingbirds andhumans). ExcretionandIonTransportII Thehumankidneyandexcretorydiseaseswillbehighlighted.Knowledgeofkidneyfunctioncrucially dependsontheunderstandingofosmoticregulationandiontransport.Examplesofpumpsrelevant 6. 7. 8. 9. 10. 11. 12. 13. 14. 16. 3 tothissectionincludedrugpumps,bilesaltexportpumpsandthecysticfibrosistransmembrane conductanceregulator. MovementandMuscleControl Anintroductiontomovement(plants,protists,culturedcells)withemphasisonthevertebrate skeletalmuscleswillbepresented. NeuralTransmissionandNervousControlI Theclasswillinvestigatethetransmissionofasignaldownaneuronandclassesofneural transmittersusingthevertebrateasaprimarymodel. Neuroscience Furtherunderstandingofsynaptictransmissionofthesignalwillbeamplifiedbypractical applicationsofneuroscience(e.g.insecticides,neurologicaldiseasesandtheirtreatments,poisons producedbysnakes,fishandplants).Anoverviewofthecomparativephysiologyofnervoussystems (e.g.cnidarians,annelids,mollusksandvertebrates)andofthebrainwillalsobepresented. CirculatorySystems Ageneralintroductiontocirculatorysystemsindiverseorganismswillbepresentedbutwithan emphasisonmammaliancirculatorysystem.Thebloodclottingcascadeandvariousgeneticdiseases associatedwiththecirculatorysystemwillbediscussed. RespirationandGasExchange Thetransportofoxygentothetissuesinvertebratesusingredbloodcells,andtransportofwaste carbondioxideisthefocusofthelecture.Adaptationstohighaltitudesandembryonicdevelopment willbeexploredaswellasadditionaldiseasesofthecirculatorysystem. DefenceandImmunityI Anintroductiontotherecognitionofselfanddefenceagainstpathogens(innatevs.adaptive)willbe presented.Thehumoralresponseinmammalsisemphasizedinthisfirstlectureoftheseries. ImmunityandImmunogenetics Thecellularresponsetopathogens(TcellsandtheassemblyofTreceptors,MHCproteinsetc)will bepresented,aswilltheconceptsofimmunetoleranceandhumandiseasesoftheimmunesystem. ImmunityandCancer Genomerearrangements(e.g.Burkett’slymphoma)inlymphocytesfollowfromperturbationsofthe immunesystem.Therewillbeageneralreviewofthecausesofcancerswithasectiondevotedto retroviruses. EvadingtheImmuneSystem AcasestudyofHIVwillbepresentedincludingthevirallifecycle,itsepidemiologyandthesocial responsibilitiesofthedisease.TheskirmishesinthebattlebetweenHIVandtheimmunesystemas wellastestedtherapies,andHIVresistancemechanismsmakeforafascinatingexploration. DefenceinOtherOrganismsandanIntroductiontoHormones Immunityininsectsandplantsisexplored,aswellasanintroductiontohormonesimportantin development. 17. 18. 4 HormonesandEndocrineSystems Developmentwillbefurtherexploredasanorchestrationofsteroidandpeptidehormonesynthesis byendocrineglands.Practicalapplicationsofhormonestudiesincludingcheatinginathletic performanceandanti-dopingmonitoring,fishbehavior,osmoregulationinhumans,andmineral balanceinhumanswillbeusedasexamples. PuttingitAllTogether:HomeostasisandReview Hormone-associateddiseases,andabriefoverviewofhomeostasisanditsimportance,willbe discussed.Participationinaguidedreviewofthecoursewillfollowwithexamplestaken fromrecentnewsitemsassociatedwiththesubjectscoveredbythecourse. B. OrganismstoEcosystems(Dr.Chippindale) (the6weeksoflecturesfollowingReadingWeek) Week7.Introduction Therelevanceofevolution;theevidenceforevolution;naturalselectioninthelabandinthewild;thepace ofevolutionarychange;evolution&diversity. Week8.GenesinPopulations Theforcesofevolutionarychange(selection,drift,migration,mutation);detectingevolution Week9.EvolutionaryEnigmas Sexandmulticellularity;originsofsex;originsofdifferentmatingtypesandgametes;consequencesof separatesexes;sexualselection&conflict;theoriginoforganisms. Week10.SpeciesandSpeciation Speciesdefinitions;modesofspeciation;hybridzones;micro-versusmacroevolution. Week11.Population&CommunityEcology Lifehistorystrategies;populationgrowth;theniche,speciesinteractions–symbioses,mutualism,parasitism etc. Week12.Ecosystems&Conservation Energyflow;productivity;elementalcycles;biodiversity;conservationbiology. C. 5 LaboratoryExercises: Informationonthelaboratoryexercisesisavailableinthelaboratorymanual,butislikelytoincludemuscle physiology,respirationphysiology,andevolution Textbooks/Readings Website:http://www.queensu.ca/biology/undergrad/courses/course/courselistings.htmlCourseText (required;second-handoldereditionsfineoruselibrarytexts): CampbellBiology,CanadianEditionbyReece,Urry,Cainet.al.,2014,publishedbyPearson. *Note:Accesstothepublisher’swebsiteisassociatedwiththetext(providedwithpurchaseofnewtext) DepartmentofBiologywebsite:http://biology.queensu.ca Datesanddetailsofreadingsandassignmentswillbeannouncedinclassand/orpostedonthecourse websiteinOnQ.DatesanddetailsforlabactivitiessessionassignmentswillbepresentedinOnQand/orthe labs. GradingScheme (ifthisischanged,amplenoticewillbegivenonthefirstdayofclassandpostedonOnQ) Component OnQtests(5) Online/Connectorother activities Lab:Assignments(announced inlab) IClickeruse:mostlectures FinalExam Weight(%) 15% 7% Date TBA TBA 35% TBA 3% 40% TBA 6 GradingMethod Mostcomponents(e.g.exams,onlinequizzes)ofthiscoursewillreceivenumericalpercentagemarks.The finalgradeyoureceiveforthecoursewillbederivedbyconvertingyournumericalcourseaveragetoaletter gradeaccordingtoQueen’sOfficialGradeConversionScale.Othercomponentswillreceivelettergrades, whichwillbetranslatedintonumericalequivalentsusingtheFacultyofArtsandScienceapprovedscale. Students’courseaverageisthenconvertedtoafinallettergradeaccordingtoQueen’sOfficialGrade ConversionScale: Queen’sOfficialGradeConversionScale NumericalCourse Grade Average(Range) A+ 90-100 A 85-89 A- 80-84 B+ 77-79 B 73-76 B- 70-72 C+ 67-69 C 63-66 C- 60-62 D+ 57-59 D 53-56 D- 50-52 F 49andbelow AcademicIntegrityandQueen’sCodeofConduct Studentsareresponsibleforfamiliarizingthemselveswiththeregulationsconcerningacademicintegrityand forensuringthattheirassignmentsandconductconformtotheprinciplesofacademicintegrity.Information isavailableintheArtsandScienceCalendar(seeAcademicRegulation1- http://www.queensu.ca/artsci/academic-calendars/regulations/academic-regulations,ontheArtsand Sciencewebsite(seehttp://www.queensu.ca/artsci/academics/undergraduate/academic-integrity),andat Biology’swebsite(http://www.queensu.ca/biology/undergrad/integrity.html)andfromtheinstructorofthis course.Departuresfromacademicintegrityincludeplagiarism,useofunauthorizedmaterials,facilitation, forgeryandfalsification,andareantitheticaltothedevelopmentofanacademiccommunityatQueen's. Giventheseriousnessofthesematters,actionswhichcontravenetheregulationsonacademicintegrity carrysanctionsthatcanrangefromawarningorthelossofgradesonanassignmenttothefailureofa coursetoarequirementtowithdrawfromtheuniversity. AccommodationPolicy,ExamConflicts,andOtherConflicts Studentswhofeeltheyneedaccommodationsfordisabilitiesorextenuatingcircumstances,orhavea conflictbetweenexamsorothercommitmentsshouldconsulttheBiologyDepartment’swebsitefordetails abouthowtoproceed(http://www.queensu.ca/biology/undergrad/integrity.html).Ingeneral,theearliera coursecoordinatorisapprisedofanextenuatingcircumstance,themorelikelyanaccommodationcanbe made.Studentsareencouragedtobeproactiveinanticipatingdifficulties,whenitispossibletodoso. 7 Studentsmayapplytowriteamake-upordeferredexamiftheyhaveanexamconflictasdefinedinthe AcademicRegulationsoftheFaculty(SeeArtsandScienceCalendarRegulation8- http://www.queensu.ca/artsci/academic-calendars/regulations/academic-regulations).Inthiscase,the studentshouldreporttotheExamsOfficefirsttoverifythatthereisagenuineexamconflict.Biology professorswillnotconsideryoursituationtobeaconflictunlessitmeetsthecriteriasetoutbytheFaculty ofArtsandSciences. Studentsmayrequestamake-upordeferredexamiftheyhaveanexamconflictwithoff-campustravel associatedwithafieldcourse(e.gBIOL-307/3.0or407/3.0)thatisheldduringthefallorwinterterms. Copyright Allmaterialpresentedisthepropertyoftheinstructor(s)unlessotherwisestatedorposted.Thirdparty copyrightedmaterials(suchasbookchaptersandarticles)haveeitherbeenlicensedforuseinthiscourse, havebeenprovidedbythetextbookpublishersforuseinthecourse,orfallunderanexceptionorlimitation inCanadianCopyrightlaw.Copyingthismaterialfordistribution(e.g.uploadingmaterialtoacommercial thirdpartywebsite)canleadtoaviolationofCopyrightlaw.Findoutmoreaboutcopyrightat http://library.queensu.ca/copyright. AccommodationofDisabilities Queen'sUniversityiscommittedtoachievingfullaccessibilityforpersonswithdisabilities.Partofthis commitmentincludesarrangingacademicaccommodationsforstudentswithdisabilitiestoensuretheyhave anequitableopportunitytoparticipateinalloftheiracademicactivities.Ifyouareastudentwithadisability andthinkyoumayneedaccommodations,youarestronglyencouragedtocontacttheDisabilityServices Office(DSO)andregisterasearlyaspossible.Formoreinformation,includingimportantdeadlines,please visittheDSOwebsiteat:http://www.queensu.ca/hcds/ds/