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UNIT COVER PAGE School District: Bremen Dist. 228 Science Department: Unit Title: Mendelian & Non-Mendelian Genetics Course: Grade Levels: Biology 9-10 Topic Areas: 4 weeks 5/19/08 Date Created: Date Modified: JoAnne Hellinga, Chad Robson, Jane Molek, Kris Cardinal, Grace Fontana, Unit Designer(s): Peg Macabobby Time Frame: Link to National/State Standards 12.11.12 12.11.13 12.11.14 12.11.16 12.11.19 12.11.20 Understand Mendel’s law of segregation and also that genes do not always separate as hypothesized by Mendel’s law of segregation. Understand that if genes are located close to each other on the same chromosome, then they are linked and may undergo independent assortment. Identify and be able to apply the following concepts; trait, alleles, dominant allele, recessive allele, gametes, genotype, homozygous, heterozygous, chromosome, meiosis, and mitosis. Answer questions about give Punnett squares. Understand how random chromosome segregation explains the probability that a particular allele will be in a gamete. Understand how to predict possible combinations of alleles in a zygote from the genetic makeup of the parents for simple dominant/recessive traits. Understand that a multicellular organism develops from a single zygote, and its phenotype (i.e., its outward appearance) depends on its genotype (i.e., its genetic makeup), which is established at fertilization. Summary of Unit The purpose of the unit is to help students understand how traits are passed on through a variety of modalities. Resources Deck of cards/dice Easter egg lab Probability lab Baby lab Practice handouts Key Words Mendel Heterozygous Heterozygous – dominant/recessive Gene/allele/trait Dominant/recessive Diploid Haploid Law of segregation/gametes Genotype/phenotype Incomplete – sex linked Codominant – multiple alleles Hybrid/purebred Probability Punnett square Monohybrid/dihybrid Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 1 STAGE 1: IDENTIFY DESIRED RESULTS Enduring Understandings Students will understand that sexual reproduction is the result of independent events in which traits are inherited from parents in a predictable manner based on probability. genes, which are located on chromosomes, are composed of segments of DNA which control inherited traits. individuals receive half of their genetic information from each parent; in cases in which two or more forms of the gene exist, some may be dominant and others are recessive. alleles for different genes segregate independently of each other. not all traits are inherited in a dominant/recessive pattern. Essential Questions What is the key idea in genetics? How do patterns of inheritance relate to me? How might the Punnett squares help to predict our own genotypes? What are the limits of using probability in genetics? What would it be like to walk in a hemophiliac/color blind person’s shoes, older couple/consumer/person with history or Huntington’s How might an insurance company feel about genetic screening? How can I best show hot my traits were inherited or how traits may be passed to my offspring? Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 2 Knowledge and Skills Students will know Mendel’s laws understand genotype vs. phenotype examples of non-Mendelian inheritance - incomplete - co-dominance - sex-linked - multiple alleles Mendelian genetics how probability can be expressed - fraction - ration - percent difference between haploid and diploid cells Students will be able to create a single-trait Punnett square make predictions based on probability laws determine genotype and phenotype show how traits are passed from parent to offspring by solving various genetic problems - dominance/recessive - inc. dominance - sex-linked - multiple alleles - co-dominance * Honors: Perform dihybrid crosses Students will be familiar with dihybrid cross Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 3 STAGE 2: DETERMINE ACCEPTABLE EVIDENCE What evidence will show that students understand? Required Assessments (brief description) Who gets the money? (Applying Medelian – Genetic concepts to solve a problem.) Other Assessments (brief description) Vocabulary/tests/quizzes Punnett square - Dominant/recessive - Incomplete dominance - Multiple allele - Co-dominance - Dihybrid (honors) Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 4 PLAN LEARNING EXPERIENCES AND INSTRUCTION What sequence of teaching and learning experiences will equip students to develop and demonstrate the desired understandings? Learning Activities W How will you ensure that all students know where they are headed in the unit, why they are headed there, and how they will be evaluated? The students will be able to complete a Punnett square in order to predict possible outcomes of a genetic cross. H How will you hook students at the beginning of the unit? E What events will help students experience and explore the big idea and questions in the unit? How will you equip them with needed skills and knowledge? Simulate inheritance of traits through lab activity. R How will you cause students to reflect and rethink? How will you guide them in rehearsing, revising, and refining their work? Identify traits, share experiences - Tongue rolling, left/right handed, hitchhiker’s thumb, PTC tasters. Take the role of an insurance company lobbying for genetic testing of potential clients. E How will you help students to exhibit and self-evaluate their growing skills, knowledge, and understanding throughout the unit? How does what you’ve learned relate to the present and future? What questions and uncertainties do you still have? T How will you tailor and otherwise personalize the learning plan to optimize the engagement and effectiveness of ALL students, without compromising the goals of the unit? Students will have opportunities to work cooperatively. O How will you organize and sequence the learning activities to optimize the engagement and achievement of ALL students? Survey traits and experiences. Mendel’s laws. Introduce key terms. Probability & Punnett squares Genetic crosses - dominant/recessive - incomplete dominant - sex-linked - multiple allele - co-dominant - dihybrid Performance assessment. Introduce key terms. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 5 Essential Questions at Topic Level Use the six facets of understanding to generate possible essential questions for the topic of your three-circle audit (curricular priorities). Explanation What is the key idea in genetics? Interpretation Application How do patterns of inheritance relate to me? How might the Punnett squares help to predict our own genotypes? (Topic Area) Mendelian & NonMendelian Genetics Empathy What would it be like to walk in a hemophiliac/color blind person’s shoes, older couple/consumer/person with history of Huntington’s? How might an insurance company feel about genetic screening? Perspective Self-Knowledge What are the limits of using probability in genetics? How can I best show how my traits were inherited or how my traits may be passed to my offspring? Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 6 Student Performance Task Unit: Mendelian & Non-Mendelian Genetics Task: Application Course: Biology Time Frame: 1 period Overarching Understanding: Students will understand that the relationships among living things are ongoing and interconnected by biological principles. Enduring Understanding: Students will understand that individuals receive half of their genetic information from each parent in cases in which two or more forms of the gene exist. Some may be dominant and others are recessive. Not all genes. Essential Question: How can I best show how my traits were inherited or how my traits may be passed to my offspring? Vignette: You have been hired to determine which one of the five men claiming to be the son of Mr. and Mrs. Jones, is the rightful heir to their estate. To evaluate your success you will create punnett squares to compare the possible outcomes resulting from the cross of the Jones’ with the five men. Standard: You will be graded on the following scale: Successful completion of punnett squares. Selecting the correct heir. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 7 Performance Task Blueprint Unit: Topic Area: Mendelian & NonMendelian Genetics Type: Application Time Frame: 1 class period Goal Your task is to solve a mystery involving genetics. Role You have been asked to determine who is the rightful beneficiary of the inheritance money. Audience Your clients are the deceased through their will. Situation The context you find yourself in is five men fighting over inheritance money. Product or Performance You will need to develop a Punnett square based on the genotype of the deceased in order to eliminate the imposters. Standards & Criteria for Success A successful result will identify the true heir. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 8 Performance Task: Regular Biology Investigation 6 Who Gets the Money? Purpose To solve a mystery involving genetics. Concepts Punnett squares Incomplete dominance Sex-linked inheritance Monohybrid cross Codominance Background This story appeared in the local paper recently: Mr. and Mrs. John Jones died in a tragic farm accident when the tractor they were riding on rolled over in a ditch. Authorities found one million dollars hidden in a feed bid in the chicken coop. The couple is known to have a son, from whom they are estranged. This man is the sole heir to the Jones fortune. Five men show up, each claiming to be the couples’ long lost son who had run away to become a sheep-herder. You are called in as a genetics expert to decide who is the rightful heir. This mystery will be solved in three parts. Procedure Complete Parts One, Two, and Three of the Who Gets the Money? Worksheet as directed by your instructor. Safety There are no particular safety concerns for this activity, but follow all normal laboratory safety rules. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 9 Performance Task: Regular Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part One: Monohybrid Cross Brown eyes are dominant over blue eyes, free earlobes are dominant over attached earlobes. Mr. Jones Mrs. Jones Carl Ray Dale Earl Robert Heterozygous, free earlobes, and homozygous brown-eyed. Heterozygous, free earlobes, and heterozygous brown-eyed. Homozygous brown-eyed, and attached earlobes. Homozygous free earlobes, blue-eyed. Heterozygous free earlobes, homozygous brown-eyed. Heterozygous free earlobes, and heterozygous brown-eyed. Homozygous free earlobes, blue-eyed. In the space below, draw two Punnett Squares showing the possible offspring of Mr. and Mrs. Jones: one for eye color and one for earlobes. Write each person’s genotypes in the chart below. Person Eye Color Earlobes Mr. Jones Mrs. Jones Carl Ray Dale Earl Robert Which men can be eliminated by these traits? Explain your reasoning for each man. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 10 Performance Task: Regular Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part Two: Co-dominance and Incomplete dominance Now that ______________________________ have been eliminated, lawyers order blood tests to try to prove their claims. The lawyers have also done some research and read that hair texture is inherited. Type A and type B blood are co-dominant over type O. Rh+ blood is dominant over Rh- blood. Hair texture exhibits incomplete dominance. Homozygous dominants (HH) have curly hair. Homozygous recessives (hh) have straight hair. Heterozygotes (Hh) have wavy hair. Mr. Jones Mrs. Jones Carl Dale Earl Homozygous type A blood, heterozygous Rh+, straight hair. Heterozygous type B blood, homozygous Rh+, wavy hair. Heterozygous type A blood, heterozygous Rh+, wavy hair. Heterozygous type A blood, homozygous Rh+, wavy hair. Type O blood, Rh-, straight hair. In the space below, draw three Punnett Squares showing the possible offspring of Mr. and Mrs. Jones: for blood type, Rh type, and hair textures. Write each person’s genotypes in the chart below. Person Mr. Jones Mrs. Jones Carl Dale Earl Blood Type Rh Type Hair Texture Which men can be eliminated now? Justify your answers for each man. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 11 Performance Task: Regular Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part Three: Sex-linked Inheritance We’re down to just _________________________________. The lawyer now orders that a vision test be performed to test for red-green color blindness. Mr. Jones Mrs. Jones Carl Dale Color blind Homozygous for normal vision Color blind Normal vision In the space below, draw a Punnett Squares showing the possible offspring of Mr. and Mrs. Jones for color blindness. Write the genotypes of the persons in the table below: Person Mr. Jones Mrs. Jones Carl Dale Vision SO: WHO GETS THE MONEY? (Don’t forget to justify your answer!) Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 12 Performance Task: Honors Biology Investigation 6 Who Gets the Money? Purpose To solve a mystery involving genetics. Concepts Punnett squares Incomplete dominance Sex-linked inheritance Monohybrid cross Codominance Background This story appeared in the local paper recently: Mr. and Mrs. John Jones died in a tragic farm accident when the tractor they were riding on rolled over in a ditch. Authorities found one million dollars hidden in a feed bid in the chicken coop. The couple is known to have a son, from whom they are estranged. This man is the sole heir to the Jones fortune. Five men show up, each claiming to be the couples’ long lost son who had run away to become a sheep-herder. You are called in as a genetics expert to decide who is the rightful heir. This mystery will be solved in three parts. Procedure Complete Parts One, Two, and Three of the Who Gets the Money? Worksheet as directed by your instructor. Safety There are no particular safety concerns for this activity, but follow all normal laboratory safety rules. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 13 Performance Task: Honors Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part One: Dihybrid Cross Brown eyes are dominant over blue eyes, free earlobes are dominant over attached earlobes. Mr. Jones Mrs. Jones Carl Ray Dale Earl Robert Heterozygous, free earlobes, and homozygous brown-eyed. Heterozygous, free earlobes, and heterozygous brown-eyed. Homozygous brown-eyed, and attached earlobes. Homozygous free earlobes, blue-eyed. Heterozygous free earlobes, homozygous brown-eyed. Heterozygous free earlobes, and heterozygous brown-eyed. Homozygous free earlobes, blue-eyed. In the space below, complete a dihybrid cross showing the possible offspring of Mr. and Mrs. Jones: one for eye color and one for earlobes. Write each person’s genotypes in the chart below. Person Eye Color Earlobes Mr. Jones Mrs. Jones Carl Ray Dale Earl Robert Which men can be eliminated by these traits? Explain your reasoning for each man. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 14 Performance Task: Honors Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part Two: Co-dominance and Incomplete dominance Now that ______________________________ have been eliminated, lawyers order blood tests to try to prove their claims. The lawyers have also done some research and read that hair texture is inherited. Type A and type B blood are co-dominant over type O. Rh+ blood is dominant over Rh- blood. Hair texture exhibits incomplete dominance. Homozygous dominants (HH) have curly hair. Homozygous recessives (hh) have straight hair. Heterozygotes (Hh) have wavy hair. Mr. Jones Mrs. Jones Carl Dale Earl Homozygous type A blood, heterozygous Rh+, straight hair. Heterozygous type B blood, homozygous Rh+, wavy hair. Heterozygous type A blood, heterozygous Rh+, wavy hair. Heterozygous type A blood, homozygous Rh+, wavy hair. Type O blood, Rh-, straight hair. In the space below, draw three Punnett Squares showing the possible offspring of Mr. and Mrs. Jones: for blood type, Rh type, and hair textures. Write each person’s genotypes in the chart below. Person Mr. Jones Mrs. Jones Carl Dale Earl Blood Type Rh Type Hair Texture Which men can be eliminated now? Justify your answers for each man. Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 15 Performance Task: Honors Biology Name: ________________________________________________ Who Gets the Money? Worksheet Part Three: Sex-linked Inheritance We’re down to just _________________________________. The lawyer now orders that a vision test be performed to test for red-green color blindness. Mr. Jones Mrs. Jones Carl Dale Color blind Homozygous for normal vision Color blind Normal vision In the space below, draw a Punnett Squares showing the possible offspring of Mr. and Mrs. Jones for color blindness. Write the genotypes of the persons in the table below: Person Mr. Jones Mrs. Jones Carl Dale Vision SO: WHO GETS THE MONEY? (Don’t forget to justify your answer!) Z:\Biology-Regular\Biology UBD Units\Genetics\Mendelian & Non-Mendelian Genetics\Mendelian & Non-Mendelian Genetics UbD.doc 16