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The Science of Sustainable Weight Loss Past, Present, & Future Bright Line Eating Book Launch Live Event New York City March 21, 2017 Susan Peirce Thompson, Ph.D. Gratitude • Middle Collegiate Church • Hay House: Christa Gabler, Mollie Langer, Lindsay McGinty, & Richelle Fredson • Arianna Hillis • Nancy Wolf • Nat Denkin • Jon Iuzzini • Lynn Coulston • Linden Morris Delrio 1 More Gratitude • Ashley Bernardi • Lucinda Blumenfeld • Nicola Kraus • Patty Gift & Reid Tracy • John Robbins • Boot Campers & Bright Lifers • BLE Research Participants 2 Yet More Gratitude • Sharon Bially • Jeff Walker, Sage Lavine, Ryan Eliason, Justin Livingston • Ocean Robbins • The Bright Line Eating Team • Mariah Perkins and Joseph Fleischman • David Thompson • Zoe, Alexis, and Maya 3 Outline of Tonight’s Talk • The Problem: A Reformulation • The Past: Traditional Approaches • The Present: Bright Line Eating 2014 – 2017 ✦ Research Findings – The Dawn of a New Day ✦ Goal Weight Gallery – Because It’s Fun ☺ • The Future: Where We Go from Here 4 Before We Begin http://BrightLineEating.com/BookLaunchReferences 5 The Problem 6 The Problem We’re getting fatter (Galka, M., 2016) 7 The Problem We’re getting fatter (Galka, M., 2016) 8 The Problem Where this goes… (Galka, M., 2016) 9 So what? Susan Peirce Thompson, Ph.D. Should We Care? • Generally speaking, “With more overweight people around, there's a new norm. Everyone's more comfortable with themselves” people don’t like being heavy • But perhaps we can fix that… (NPR, 2017) 11 The Fat Acceptance Movement • The bell curve argument 12 The Fat Acceptance Movement • • • • The bell curve argument Our genetic distribution has stayed the same Our environment has changed The average BMI for a woman long ago was 20.6 – a “right-sized body" ✦ Overweight was rare and obesity was unknown • The average BMI for a woman today is about 28 ✦ ✦ A BMI of 28 is in the middle of the “Overweight” range 35% of adult women are Obese 13 But Science Says: Weight Loss is a Losing Game “The real problem is not in losing the weight, but in keeping it off for any meaningful length of time. Numerous sources show that almost every lifestyle intervention works for the first 3-6 months, but then the weight comes rolling back.” (Lustig, 2012) 14 Weight Loss is a Losing Game "Declines in energy expenditure favoring the regain of lost weight persist well beyond the period of dynamic weight loss." (Rosenbaum, et al, 2008) “You can’t lose weight on a diet. The problem isn’t willpower, it’s neuroscience. You can’t—and shouldn’t—fight back.” (Aamodt, 2016) 15 Today’s Foods are Addictive 16 The Toughest Drug to Quit • You need to eat • 80% of the calories in the supermarket have added sugar • The cues are everywhere • The social pressure is ridiculous • Eating is synonymous with fun, celebration, recreation, leisure, and comfort • It’s not an addiction that society takes seriously… yet 17 The Costs of Staying Heavy Research shows that obesity is associated with… • Emotional issues ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ obese children are viewed as the least desirable friend obese children victims of repeated group aggression obese adolescents less often accepted into high-ranking colleges obesity is linked with depression being made less visible (business) denied choice assignments in the workplace size discrimination loss of self esteem negative body image negative assumptions & nasty comments being ignored being stared at 18 Additional Challenges Research shows that obesity is associated with… ✦ Chronic disease: Elevated risks for ➢ diabetes ➢ cardiovascular disease ➢ osteoarthritis ➢ inflammation ➢ leptin resistance ➢ insulin resistance and dysregulation 19 More Issues Research shows that obesity is associated with… • Musculoskeletal problems ✦ ✦ ✦ ✦ ✦ ✦ ✦ ✦ mobility challenges: difficulty with standing, bending, walking, and climbing skeletal and Joint deterioration reduced postural control reduced stability & loss of balance increased pain increased risk of knee osteoarthritis lower back pain, reduced bone density in children challenges living and navigating in the world 20 The Brain Suffers Research shows that obesity is associated with… • Poorer mental performance ✦ ✦ ✦ ✦ ✦ ✦ ✦ visuospatial organization global executive functioning planning mental flexibility reduced cerebellar function increased cognitive decline poorer memory function • Physical changes (premature aging) ✦ ✦ ✦ ✦ ✦ greater degree of atrophy increased risk of neurodegeneration oxidative stress decreased white matter dementia, Alzheimer’s 21 We Can’t Afford to Keep Going • The World Economic Forum estimates that by 2030 we’ll spend $47 trillion on illnesses linked to obesity • We can’t afford it personally, either ✦ An obese man spends $6,518 extra per year ✦ An obese woman spends $8,365 extra per year 22 The Pickle We’re In • There is not a single peer-reviewed, scientific study showing any intervention, surgery, or weight-loss program successfully helping a cohort of overweight or obese people to get down to goal weight and remain there • Not one • And by 2030, 50% of us will be obese 23 24 The Science of Sustainable Weight Loss PAST 25 What’s been done about all this so far? Susan Peirce Thompson, Ph.D. Commercial Diets • There are lots of studies comparing commercial diets • This graph is from just one meta analysis • The numbers on the lines represent the number of studies comparing those two diets 27 Johnston BC, Kanters S, Bandayrel K, et al. (2014). Comparison of weight loss among named diet programs in overweight and obese adults: a network meta-analysis. JAMA doi:10.1001/jama.2014.10397 Traditional Weight Loss Programs Here’s a summary of what’s been shown between the literature so far: • All diets work equally well – weight loss differences are small to non-existent • The diet that works is any diet that a patient will adhere to • Weight loss takes place in the first 6 months • From 6-12 months plateau, then regain 28 Other options? Susan Peirce Thompson, Ph.D. 12-Step Programs • 1939 – Alcoholics Anonymous (AA) • 1960 – Overeaters Anonymous (OA) Food Addicts Anonymous (FAA) (1987) ✦ Anorexics and Bulimics Anonymous (ABA) (1993) ✦ Compulsive Eaters Anonymous-HOW (CEA-HOW) (1996) ✦ Food Addicts in Recovery Anonymous (FA) (1998) ✦ Eating Disorders Anonymous (EDA) (2000) ✦ GreySheeters Anonymous (GSA) ✦ Recovery From Food Addiction, Inc. (RFA) ✦ Food Compulsions Anonymous (FCA) ✦ 30 12-Step Programs Pros and Cons • Pros Significant, sustained weight loss in a subset of people ✦ Helpful for those high on the Susceptibility Scale ✦ Free (mostly) ✦ Benefits other than weight loss ✦ • Cons Difficult to study scientifically ✦ Trade-off in effectiveness among groups/programs mixed results ✦ Not scientifically grounded ✦ Slow-growing, not for everyone ✦ 31 Anything else? Bariatric Surgery • Hugely popular – about 200,000 per year Bariatric Surgeries 60% • Types of programs ✦ ✦ ✦ Gastric Sleeve (currently most popular) Roux-En-Y Gastric Bypass Gastric Band Biliopancreatic Diversion with Duodenal Switch • Reduce stomach volume and reduce digestion • Generally prescribed when BMI > 40 or > 35 with comorbidity 40% Percentage of Total Surgeries ✦ 50% 30% 20% 10% • Success is defined as keeping off half the excess weight needed to have a BMI of 25. 0% 2011 2012 2013 2014 Year RNY 33 Band Sleeve BPD/DS Revisions Other 2015 Bariatric Surgery • Results 1, 3, and 5 years after surgery: ✦ 13.3% failure by the end of one year ✦ 20.6% failure by the end of three years ✦ 38.5% failure by the end of five years • Before surgery, the average BMI was 43.9 • 5 years after surgery, the average BMI was 32.3 34 Bariatric Surgery • What about diabetes? • Bariatric surgery severs neurons in the gut ✦ 51% complete remission of Type 2 Diabetes after one year ✦ 38% after three years ✦ 20% after five years • Reminds me of my sense of smell 35 Why so much weight regain? Susan Peirce Thompson, Ph.D. The Biggest Loser • The Biggest Loser is an eat less, exercise more reality TV show…to the extreme ✦ Rapid Weight Loss (330 to 200 lbs in five months) • A recent article garnered huge attention by publishing a “where are they now?” piece, 6 years after the end of the season • 13/14 gained back most or all of the weight ✦ Not shocking, typical • The shock was what happened to their resting metabolic rate 37 6 Years After “The Biggest Loser” • The Biggest Loser contestants were burning 500 calories a day fewer than would be expected for someone their age, gender, and size • 6 years later • After they had already regained some or all of their weight • the body remembers 38 But that’s not the only sustained physiological change Susan Peirce Thompson, Ph.D. Hormonal Adaptations • Hormones affect our feelings of hunger and our desire for food • Their levels are affected by weight loss Hormone Where released Leptin Fat cells Ghrelin gastric inhibitory polypeptide peptide YY GLP-1 cholecystokinin pancreatic polypeptide amylin Sumithran, P., et al. (2011). 40 gastrointestinal tract and pancreas gastrointestinal tract and pancreas gastrointestinal tract and pancreas What is does acts in the hypothalamus to reduce food intake and increase energy expenditure. stimulates hunger may promote energy storage inhibit intake Hormonal Adaptations to Weight Loss • Researchers gave overweight and obese patients a 500 cal/day diet of Optifast shakes plus nonstarchy vegetables for 10 weeks • After losing an average of 30 pounds, people are hungrier following meals and have a greater desire to eat than before the weight loss • This change persists at least one year after the weight loss Sumithran, P., et al. (2011). 41 Hormonal Adaptations to Weight Loss • Why? • Hormone levels changed during weight loss; a portion of that change persists even a year later Sumithran, P., et al. (2011). 42 Isn’t ANYONE successful? Susan Peirce Thompson, Ph.D. National Weight Control Registry • Established 1994 (23 years ago) ✦ Rena Wing, Ph.D. Brown Medical School ✦ James Hill, Ph.D. University of Colorado • Tracking 10,000 people who have succeeded in sustaining their weight loss ✦ What’s 10,000 / 108,000,000 ? ✦ .0000925 44 But Here’s the Thing: • To Register ✦ Lose at least 30 pounds ✦ Keep it off for at least one year • Studies of the NWCR population (2012—2016) ✦ Average BMI is 25.1 ➢ 38% are Overweight ➢ 13% are Obese 45 NWCR Key Takeaway • There is no "one size fits all strategy" for successful weight loss maintenance, but longterm weight-loss maintenance is possible and requires sustained behavior change 46 Big Picture Milestones Susan Peirce Thompson, Ph.D. An Emerging Understanding • 1991: Garner & Wooley conclude: “It is only the rate of weight regain, not the fact of weight regain, that appears open to debate” • 2007: Mann, et al. conclude: “It appears that dieters who manage to sustain a weight loss are the rare exception, rather than the rule. Dieters who gain back more weight than they lost may very well be the norm, rather than an unlucky minority” • 2008: Weight regain continues 1, 2, and 5 years later • 2010: Providing special diet food for free slows, but does not halt regaining weight • 2014: Greatly lowering the bar for significance (11—15 pounds lost at the end of one year), Johnston et al. conclude that “Significant weight loss” can result from any diet. Basically, the best diet is whatever a patient will adhere to. • 2015: In each year, fewer than 1 in 300 obese people reach a BMI <25 48 The Science of Sustainable Weight Loss PRESENT 49 Birth of Bright Line Eating th January 26 2014 50 History of BLE Boot Camps (BC) • First BC – Oct 2014 • 10 BC between Oct 2014 – Dec 2016 • Home Study / Self-Starter Pack – June & Oct 2016 • 15,000+ participants – Since Oct 2014 • In 75+ countries 51 Other BLE Programs • Bright Lifers ✦ December 2015 ✦ ~2,000 Active members • Bright Line Healing – June 2016 • Bright Healers – September 2016 52 Changes Since January 2017 • 14 Day Challenge – 8,691 participants • Evergreen Boot Camp – 3,012 participants 53 BLE Research (Oct 2015) • 55% of Boot Campers join our research program • 63% fill out at least 1 survey (including Exit Survey) • Surveys track: ✦ Demographics & personal stats ✦ Weekly weight & daily Bright Lines ✦ Habits & tool usage ✦ Changes in cravings, hunger, and medications ✦ Celebrations & struggles ✦ Attitudes & effort 54 A Hole in the Research Funnel • 62% of Boot Campers who sign up for the research program complete the required surveys • • • Self-selected Presumably most of the rest aren’t successful, but we can’t be sure Time and life demands • 36% of Boot Campers who don’t sign up for the research program complete an Exit Survey • • • The rest are presumably not interested in research Presumably most of the rest aren’t successful, but we can’t be sure Time and life demands 55 Boot Camp Research • Here is what we’ve learned from the Boot Camp Research program 56 Boot Camp Research • 8,412 Total participants (BC & SSP) • Participants lose an average of 8% of their weight during the boot camp (17 pounds) • 1,997 participants (24%) become Bright Lifers 57 Boot Camp Weight Loss 58 Weight Loss & Dietary Preferences Dietary preferences before BLE compared with weight loss during the Boot Camp 59 Weight Loss & Frequency of Exercise Amount of exercise compared with weight loss during the Boot Camp 60 Changes in Cravings, Hunger, and Distress 61 Confidence in Reaching & Maintaining Goals 62 Peace & Serenity with Food 63 Medical Changes 64 Follow-Up Research • Began June 2016 • Open to all past Boot Campers • About 1,500 participants thus far • Monthly surveys, ongoing 65 Key Takeaways 1. Bright Lines matter 2. Being a Bright Lifer matters 3. “Goal weight” can be renegotiated downward 66 The Impact of the Bright Lines • For each Bright Line: ✦ ✦ Scale: 1=daily breaks & 4=total abstinence, Perfect adherence to all 4 BL would score 16 • Brightness & Weight Loss Over 8 Months Score of 15 – 16 = 25.3 lb loss ✦ Score of 13 – 14 = 16.1 lb loss ✦ Score of 11 – 12 = 3.1 lb loss ✦ Score of 10 or less = 16.5 lb gain ✦ 67 The Impact of Bright Lifers • Non-Bright Lifers Score of 15 – 16 = 16 lb loss (fewer) ✦ Score of 13 – 14 = 9 lb loss ✦ Score of 11 – 12 = 2.3 lb loss ✦ Score of 10 or less = 13.9 lb gain ✦ • 8 pound difference 68 Follow-Up Research • Many Bright Lifers on the Maintenance Plan adjust their goal weight downward ✦ Scores of 15 – 16 =13.8 lb loss ✦ Scores of 13 – 14 = 7.9 lb loss ✦ Scores of 12 or less = no net change of weight • On average, over the 8-month follow-up period, there was no regained weight while following the Maintenance Plan! 69 Follow-Up Research • Non-Bright Lifers on the Maintenance Plan stayed at original goal weight 70 To Date • After the Boot Camp ends, 87% of people maintain their weight loss or continue to lose • Within one year, 28% have made it down to goal weight and many more are still losing • Of those who get to goal weight, 84% are maintaining it 71 To Date • On average, of those who still need to lose weight after the Boot Camp ends, those who choose to become Bright Lifers continue to lose, and those who don’t, stall out • As a group, they stall out because 40% of them aren’t following the Bright Lines anymore 72 The Bright Line Eating Goal Weight Gallery 73 Goal Weight Gallery • Started Goal Weight Gallery in 2016 • Added new people for Bright Line Eating book • Next section: ✦ 17 new people at goal weight ✦ 3 people, while not at goal weight, who have lost over 100 lbs ✦ 16 check-ins with people in the original GW Gallery or in the book 74 Goal Weight Gallery Caroline Altimani • Paris, France • 155 to 137 lbs • Weight Loss: 3 months • Maintenance: 2 months 75 Goal Weight Gallery Caroline Altimani • “This is the first time in 37 years I don’t feel uncomfortable in my body” • Caroline has MS ✦ 76 No more episodes Goal Weight Gallery Lisa Phillips • 4’ 11” • 125 to 97 lbs • Doing BLE for 1 year 5 months • Weight Loss: 6 months • Maintenance: 11 months 77 Goal Weight Gallery Alyx Coble-Frakes • Age 25 • 186 to 146 lbs • Doing BLE for 1 year 5 months • Weight Loss: 6 months • Maintenance: 11 months 78 Goal Weight Gallery Alyx Coble-Frakes • “The fact that I have maintained [my weight] for coming up on a year is amazing to me and has never happened before. It gives me so much hope for the future.” • Is back on weight loss plan to aim for 130 lbs 79 Goal Weight Gallery Josie Colicchia • Melbourne, Australia • 5’ 6” • 196 to 134 lbs • Weight Loss: 12 months • Maintenance: 6 weeks 80 Goal Weight Gallery Josie Colicchia • My health has had a 360 degree change. I had suffered leaky gut/food intolerances, atrophic gastritis, and 5-day migraines for 16 years or more. …Today with BLE, I no longer have food intolerances, my gut flora corrected itself without supplements, and my migraines have almost entirely gone away. • 400+ days without eating outside the Bright Lines 81 Goal Weight Gallery Susan Cook • 5’ 0” • 189 to 121 lbs • Weight Loss: 10 months • Maintenance: 7 months 82 Goal Weight Gallery Susan Cook • Off all supplements and prescriptions, including high cholesterol drugs of over 20 years. • I love weighing the same I did as a high school athlete. 83 Goal Weight Gallery Riva Danzig • Bronx, New York, USA • Age 68 • 5’ 7” • 202 to 133 lbs • Weight Loss: 6 months • Maintenance: 7 months 84 Goal Weight Gallery Khosi Ferris • South Africa & Thailand • 141 to 119 lbs • Weight Loss: 7 months • Maintenance: 7 months 85 Goal Weight Gallery Khosi Ferris • “I am so in love with my right size body. I did not believe it was possible to organically loose weight and reach my ideal goal weight but today I can attest that it’s so possible…!” • “BRIGHT LINE EATING ROCKS MY WORLD!!!” 86 Goal Weight Gallery Chloe Ginther • Alberta, Canada • 213 to 120 lbs • Weight Loss: 10 months • Maintenance: 5 months 87 Goal Weight Gallery Chloe Ginther • I was relegated to the sidelines and missed out on my own life. • It was difficult to fit into a bathroom stall. • Now my zest for life has returned, I’m no longer depressed, I’m active, productive, full of joy. 88 Goal Weight Gallery Ed Rafferty • 6’ • 210 to 164 lbs • Weight Loss: 6 months • Maintenance: 18 months 89 Goal Weight Gallery Ed Rafferty • “In 35 years of recovery in another 12 step fellowship, I could arrest other symptoms of my addiction, but I stayed fat no matter what I did.” • Completely off all heart medication and insulin 90 Goal Weight Gallery Irina Lee • Oslo, Norway • 5’ 7” • 176 to 136 lbs • Weight Loss: 200 days • Maintenance: 11 months 91 Goal Weight Gallery Irina Lee • “[Because of BLE,] I've …decided to change the direction of my career. I recently bought the Norwegian rights for the Bright Line Eating book …to spread this message to a broader audience • I have finally found peace. Nothing beats the feeling of waking up with integrity and selfworth. 92 Goal Weight Gallery Deb Leeson • 4’ 11” • 135 to 101 lbs • Weight Loss: 9 months • Maintenance: 3 months 93 Goal Weight Gallery Deb Leeson • “I have had health challenges in the past related to fibromyalgia and chronic fatigue. Since beginning BLE my energy levels have risen, my thinking is a lot clearer and physically I am stronger and more active.” 94 Goal Weight Gallery Sherry Balthazor • 5’ 4” • 210+ to 137 lbs • Weight Loss: 1 year, 11 days • Maintenance: 1 month 95 Goal Weight Gallery Sherry Balthazor • I was so sick from depression, anemia, vitamin deficiency, diabetes, high blood pressure, fibromyalgia, IBS, migraines, neuropathy, osteoarthritis, osteopenia, acid reflux, chronic pain, asthma, sleep apnea, and insomnia…and I was taking medication for all of it. • Now I am only taking a small dose of blood pressure medication and I’m about to complete wean off of it. • Has NEVER broken her Bright Lines. 96 Goal Weight Gallery Patricia Smith • San Miguel, Mexico • Age 65 • 5’ 3.5” • 225 to 135 lbs • Weight Loss: 14 months • Maintenance: 7 months 97 Goal Weight Gallery Patricia Smith • “I do not use food for entertainment, for emotional reasons, for boredom or as a reward. Food has become nourishment for my body.” • Off all medications for high blood pressure, cholesterol, and Type 2 Diabetes. 98 Goal Weight Gallery Jackie Stapleton • Jerusalem, Israel • Age 80 • 5’ 7” • 176 to 136 lbs • Weight Loss: 5 months • Maintenance: 11 months 99 Goal Weight Gallery Jackie Stapleton • “I love my body and feel alive and better physically than I have in years. And I reached goal weight before age 80.” 100 Inspiration Gallery 101 Inspiration Gallery Tammy Palmer • Age 58 • 5’ 3” • 329 to 224 lbs • Lost 105 pounds in 9 months • Goal Weight: 129 lbs 102 Inspiration Gallery Tammy Palmer • “When I started Bright Line Eating, I was on two different blood pressure medications and was having trouble keeping my blood pressure at 140/90. I am now off all blood pressure medication and my blood pressure is staying around 120/78.” • Before I was constantly thinking about food. Now I plan my meals and don’t think about them again until mealtime. 103 Inspiration Gallery Tara Bogdon • Age 41 • 5’ 5” • 381 to 190 lbs • Lost 191 pounds in 9 months • Goal Weight: 125 lbs 104 Inspiration Gallery Tara Bogdon • “I couldn’t sit in a booth because I didn’t fit. I always worried about whether chairs would have arms or not, because if they had arms I wouldn’t fit. When I got my haircut I always apologized and hoped my weight wouldn’t break the chair. I had the seat in my car pushed back all the way and still my stomach brushed the steering wheel and made driving difficult. …I would never walk up the bleachers [to sit with my students] because I was afraid I’d break them, or shake them too badly.” 105 Inspiration Gallery Chuck Meadors • Age 59 • 5’ 10” • 412 to 303 lbs • Lost 109 pounds in 6 months • Goal Weight: 165 lbs 106 Inspiration Gallery Chuck Meadors • “I was achy and in pain all the time. When I would get up from sitting or out of bed, I had to take a moment for the pain to subside before I could start walking. …Now I can bound upstairs with no problem.” • A1C was pre-diabetic and now it is normal. 107 Check-In from Gallery & Book Julia Carol Released 81 lbs Weight Loss: 8 months Maintenance: 7 months Valerie Conner Released 40 lbs Weight Loss: 130 days Maintenance: 14 months Nathan Denkin Released 40 lbs Weight Loss: 5.5 months Maintenance: 20 months Check-In from Gallery & Book Jan Deutsch Released 145 before & 47 lbs on BLE Weight Loss: 9 months on BLE Maintenance: 16 months 109 Linden Morris Delrio Released 64 lbs Weight Loss: 6 months Maintenance: 22 months Check-In from Gallery & Book Colleen Egan Released 30 lbs Weight Loss: 5 months Maintenance: 20 months Linda Hahn Released 115 lbs Weight Loss: 10 months Maintenance: 15 months 110 Corina Flora Released 70 lbs Weight Loss: 8 months Maintenance: 18 months Check-In from Gallery & Book Jenny Hazelton Released 54 lbs Weight Loss: 14 months Maintenance: 1 month Beth Kerrick Released 38 lbs Weight Loss: 7 months Maintenance: 10 months 111 Donna Montgomery Released 62 lbs Weight Loss: 8 months Maintenance: 14 months Check-In from Gallery & Book Jody Platt Released 25 lbs Weight Loss: 6 months Maintenance: 14 months Scott Steinhorst Released 15 lbs Weight Loss: 5 weeks Maintenance: 16 months 112 Meg Queior Released 137 lbs Weight Loss: 2 years Maintenance: 7 months Check-In from Gallery & Book Ellen Weinman Released 38 lbs Weight Loss: 5.5 months Maintenance: 10 months 113 Tami Oren Released 64 lbs Weight Loss: 13 months Maintenance: 1 month The Science of Sustainable Weight Loss FUTURE 114 • We’re standing at the cusp of something HUGE 115 Never before, in all of human history, has there been a scientifically verified process by which someone who is overweight or obese can get down into a right-sized body and stay there. 116 Now there is. 117 • And voila! • The real work begins. 118 The Job Ahead • We need to continue collecting data • We need to analyze, write up, and publish the data • Write grants • Collaborate • Start some new, very important projects 119 Questions: • Can the weight loss be sustained? ✦ Five years, ten years, twenty, thirty? • What factors drive success? ✦ Can we tweak the program to improve it further? • How do the brain and body change? ✦ And what are the individual differences? 120 University of Rochester • 2016 – Adjunct Associate Professor of Brain and Cognitive Sciences • Opportunities for research partnerships 121 Reversing Dopamine Downregulation 122 Study #2 • Metabolic and hormonal changes accompanying achievement and maintenance of goal weight after significant weight loss • Leptin, ghrelin, gastric inhibitory polypeptide, peptide YY, GLP-1, cholecystokinin, pancreatic polypeptide, amylin 123 And It’s Begun • Earlier this year, Andrew Kurt Thaw, Ph.D. and Sabrina Grondhuis, Ph.D. from Millsaps College submitted the first paper on Bright Line Eating for publication ✦ Bright Line Eating: A Novel Web-Based Program • In April, Dr. Thaw will travel to Chicago for the Experimental Biology conference and will be presenting research findings on Bright Line Eating at the session on Energy Balance, Macronutrients, and Weight Management 124 Partnership #2 • A few weeks ago, Kathryn Lively, Ph.D., Professor at Dartmouth College, reached out to start a partnership • Identity changes in sustained weight loss 125 Daily Companion – Big Data Tracks: • Weight • Food journal • Bright Lines • Meditation • And much more! • And more to come! 126 The Missing Pieces • Scientific grounding • Abundance of whole foods, with large quantities of produce ✦ Soothing to brain & body • Deep understanding of addiction ✦ Bright lines 127 The Missing Pieces • Focus on habits & automaticity ✦ Exercise later, not now • Ongoing community & support • Focus on being unstoppable—not necessarily perfect ✦ Simply Rezoom 128 There is hope. Happy, Thin, & Free! 129 Here’s That URL Again http://BrightLineEating.com/BookLaunchReferences 130 Any questions? Susan Peirce Thompson, Ph.D.