Download Dr. Jian Xu, Assistant Professor Department of Biological Sciences

Dr. Jian Xu, Assistant Professor
Department of Biological Sciences and NUS Centre for Bio-Imaging Sciences
National University of Singapore (NUS)
Email: [email protected]
Lab Website: www.rootsprout.com
Researchgate: www.researchgate.net/profile/Jian_Xu44
Educational Qualifications:
• Ph.D. in Molecular Genetics, 2005, Utrecht University, The Netherlands
Professional Experience:
• Postdoctoral Research Fellow, 2005-2008, Utrecht University, The Netherlands
• NWO (Netherlands Organization for Scientific Research) VENI Postdoctoral Research
Fellow, 2008-2009, Utrecht University, The Netherlands
• Visiting Senior Research Fellow, 07/2008-09/2008, National University of Singapore
• Guest Professor, 2007-2010, National Key Laboratory of Crop Genetic Improvement,
Huazhong Agricultural University, China
• Assistant Professor, 2009-present, National University of Singapore
Research Fields:
Stem Cell Integrity; Tissue Homeostasis; Regeneration; Stress Recovery
Notable Awards and Grants:
• NWO (Netherlands Organization for Scientific Research) VENI Award, 2008, 1st position
in the Earth and Life Sciences section, honourable.
• NUS Young Investigator Award (NUS YIA), 2009.
Publications:
• Zhang, Y.H., Zheng, L.L., Hong, J.H., Gong, X.M., Zhou, C., Pérez-Pérez, J.M. and Xu,
J.* (2016) TOPOISOMERASE1α acts through two distinct mechanisms to regulate stele
and columella stem cell maintenance in the Arabidopsis root. Plant Physiol DOI:
10.1104/pp.15.01754.
• Gong, X., Flores-Vegara, M.A., Hong, J.H., Chu, H.W., Lim, J., Franks, R.G., Liu, Z.C.
and Xu, J. (2016) SEUSS integrates gibberellin signalling with transcriptional inputs from
the SHR-SCR-SCL3 module to regulate middle cortex formation in the Arabidopsis root.
Plant Physiol DOI: 10.1104/pp.15.01501.
• Seah, Y.F., El Farran, C.A., Warrier, T., Xu, J. and Loh Y.H. (2015) Induced pluripotency
and gene editing in disease modelling: perspectives and challenges. Int J Mol Sci 16,
28614-28634.
• Yu, Q.Q., Zhang, Y., Wang, J., Yan, X., Wang, C., Xu, J. and Pan, J.W. (2015) Clathrinmediated auxin efflux and maxima regulates hypocotyl hook formation and lightstimulated hook opening in Arabidopsis. Mol Plant DOI: 10.1016/j.molp.2015.09.018.
• Li, J.T., Zhao, Y.*, Chu, H.W., Wang, L.K., Fu, Y.R., Lu, P., Upadhyaya, N., Chen, C.L.,
Mou, T.M., Feng, Y.Q., Kumar, P. and Xu, J.* (2015) SHOEBOX modulates root
meristem size in rice through dose-dependent effects of gibberellins on cell elongation
and proliferation. PLoS Genet 11, e1005464. (Featured on the frontpage of the journal
website).
• Hong, J.H., Chu, H.W., Zhang, C., Ghosh, D., Gong, X.M. and Xu, J. (2015) A
quantitative analysis of stem cell homeostasis in the Arabidopsis columella root
cap. Front Plant Sci 6, 206.
• Ahmadi, N., Audebert, A., Bennett, M.J., Bishopp, A., Costa de Oliveria, A., Courtois, B.,
Diedhiou, A., Diévart, A., Gantet, P., Ghesquière, A., Guiderdoni, E., Henry, A., Inukai,
Y., Kochian, L., Laplaze, L., Lucas, M., Luu, D.T., Manneh, B., Mo, X., Muthurajan, R.,
Périn, C., Price, A., Robin, S., Sentenac, H., Sine, B., Uga, Y., Véry, A.,A., Wissuwa, M.,
Wu, P. and Xu, J. (2014) The roots of future rice harvests. Rice 7, 29.
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Huang, J.B., Liu, H.L., Chen, M., Li, X.J., Wang, M.Y., Yang, Y.L., Wang, C.L., Huang,
J.Q., Liu, G.L., Liu, Y.T., Xu, J., Cheung, A.Y. and Tao, L.Z. (2014) ROP3 GTPase
contributes to polar auxin transport and auxin response and is important for
embryogenesis and seedling growth in Arabidopsis. Plant Cell 26, 3501-3518.
Wang, L.K., Chu, H.W., Li, Z.Y., Wang, J., Li, J.T., Qiao, Y., Fu, Y.R., Mou, T.M., Chen,
C.L. and Xu, J. (2014) Origin and development of the root cap in rice. Plant Physiol 166,
603-613.
Ghosh, D.* and Xu. J.* (2014) Abiotic stress responses in plant roots: a proteomics
perspective. Front Plant Sci 5, 6. doi: 10.3389/fpls.2014.00006.
Guo, J.Z., Wei, J., Xu, J. and Sun, M.X. (2013) Inducible knock-down of GNOM during
root formation reveals tissue-specific response to auxin transport and its modulation of
local auxin biosynthesis. J Exp Bot 65, 1165-1179.
Chu, H.W., Liang, W.Q., Li, J., Hong, F., Wu, Y.F., Wang, L.K., Wang, J., Wu, P., Liu,
C.M., Zhang, Q.F., Xu, J.* and Zhang, D.B.* (2013) A CLE-WOX signaling module
regulates root meristem maintenance and vascular tissue development in rice. J Exp Bot
65, 5359-5369.
Hong, J.H., Seah, S.W. and Xu, J. (2013) The root of ABA action in environmental stress
response. Plant Cell Rep 32, 971-983.
Sassi, M.*, Wang, J., Ruberti, I., Vernoux, T.* and Xu, J.* (2013) Shedding light on auxin
movement: light-regulation of polar auxin transport in the photocontrol of plant
development. Plant Signal Behav 8, e23355.
Sassi, M., Lu, Y., Zhang, Y.H., Wang, J., Dhonukshe, P., Blilou, I., Dai, M.Q., Li, J.,
Gong, X.M., Jaillais, Y., Yu, X.H., Traas, J., Ruberti, I., Wang, H.Y., Scheres, B.,
Vernoux, T.* and Xu, J.* (2012) COP1 mediates the coordination of root and shoot
growth by light through modulation of PIN1 and PIN2-dependent auxin transport in
Arabidopsis. Development 139, 3402-3412. (Featured in “in this issue” of the journal).
Cruz-Ramírez, A., Díaz-Triviño, S., Blilou, I., Grieneisen, V.A., Sozzani, R., Zamioudis,
C., Miskolczi, P., Nieuwland, J., Benjamins, R., Dhonukshe, P., Caballero-Pérez, J.,
Horvath, B., Long, Y.C., Mähonën, A.P., Zhang, H.T., Xu, J., Murray, J.A.H., Benfey,
P.N., Bako, L., Marée, A.F.M., and Scheres, B. (2012) A bistable circuit involving
SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell
division. Cell 150, 1002-1015.
Dai, M.Q., Zhang, C., Kania, U., Chen, F., Xue, Q., Mccray, T., Li, G., Qin, G.J., Wakeley,
M., Terzaghi, W., Wan, J.M., Zhao, Y.D., Xu, J., Friml, J., Deng, X.W. and Wang, H.Y.
(2012) A PP6-type phosphatase holoenzyme directly regulates PIN phosphorylation and
auxin efflux in Arabidopsis. Plant Cell 24, 2497-2514.
Li, J., Chu, H.W., Zhang, Y.H., Mou, T.M., Wu, C.Y., Zhang, Q.F. and Xu, J. (2012) HGW
encodes a ubiquitin-associated (UBA) domain protein regulating heading date and grain
weight in rice. PLoS ONE 7, e34231.
Zhou, X.J., Li, Q., Chen, X., Liu, J.P., Zhang, Q.H., Liu, Y.J., Liu, K.D.* and Xu, J.* (2011)
The Arabidopsis RETARDED ROOT GROWTH gene encodes a mitochondria-localized
protein that is required for normal cell division in the root meristem. Plant Physiol 157,
1793-1804.
Zhou, W., Wei, L., Xu, J., Zhai, Q., Jiang, H., Chen, R., Chen, Q., Sun, J., Chu, J., Zhu,
L., Liu, C.M., Li, C. (2010) Arabidopsis Tyrosylprotein Sulfotransferase Acts in the
Auxin/PLETHORA Pathway in Regulating Postembryonic Maintenance of the Root Stem
Cell Niche. Plant Cell 22, 3692-3709.
Dhonukshe, P., Huangm F., Galvan-Ampudia, C.S., Mähönen, A.P., Kleine-Vehn, J., Xu,
J., Quint, A., Prasad, K., Friml, J., Scheres, B. and Offringa, R. (2010) Plasma
membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs
to direct apical PIN recycling. Development 137, 3245-3255.
Willemsen, V., Bauch, M., Bennett, T., Campilho, A., Wolkenfelt, H., Xu, J., Haseloff, J.
and Scheres, B. (2008) The NAC domain transcription factors FEZ and SOMBRERO
control the orientation of the cell division plane in Arabidopsis root stem cells. Dev Cell
15, 913-922.
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Grieneisen, V.A., Xu, J., Maree, A.F.M., Hogeweg, P. and Scheres, B. (2007) Auxin
transport is sufficient to generate a maximum and gradient guiding root growth. Nature
(Article) 449, 1008-1013.
Scheres, B. and Xu, J. (2006) Polar auxin transport and patterning: grow with the flow.
Genes Dev 20, 922-926.
Wisniewska, J., Xu, J., Seifertova, D., Brewer, P.B., Ruzicka, K., Blilou, I., Benkova, E.,
Scheres, B. and Friml, J. (2006) Polar PIN Localization Directs Auxin Flow in Plants.
Science 312, 883.
Xu, J., Hofhuis, H., Heidstra, R., Sauer, M., Friml, J. and Scheres, B. (2006) A molecular
framework for plant regeneration. Science 311, 385-388. (Featured in Nature Reviews
Molecular Cell Biology 7, 154, and Nature Reviews Genetics 7, 157.)
Xu, J. and Scheres, B. (2005) Cell Polarity: ROPing the ends together. Curr Opin Plant
Biol 8, 613-618.
Li, L., Xu, J., Xu, Z.H. and Xue, H.W. (2005) Brassinosteroids Stimulate Plant Tropisms
Through Modulation of Polar Auxin Transport in Brassica and Arabidopsis. Plant Cell 17,
2738-2753.
Fiers, M., Golemiec, E., Xu, J., van der Geest, L., Heidstra, R., Stiekema, W. and Liu,
C.M. (2005) The 14-Amino Acid CLV3, CLE19, and CLE40 Peptides Trigger
Consumption of the Root Meristem in Arabidopsis through a CLAVATA2-Dependent
Pathway. Plant Cell 17, 2542-2553.
Xu, J. and Scheres, B. (2005) Dissection of Arabidopsis ADP-RIBOSYLATION FACTOR
1 Function in Epidermal Cell Polarity. Plant Cell 17, 525-536.
Blilou, I., Xu, J., Wildwater, M., Willemsen, W., Paponov, I., Friml, J., Heidstra, R., Aida,
M., Palme, K. and Scheres, B. (2005) The PIN auxin efflux facilitator network controls
growth and patterning in Arabidopsis roots. Nature (Article) 433, 39-44.
Casamitjana-Martinez, E., Hofhuis, H.F., Xu, J., Liu, C.M., Heidstra, R. and Scheres, B.
(2003) Root-specific CLE19 overexpression and the sol1/2 suppressors implicate a CLVlike pathway in the control of Arabidopsis root meristem maintenance. Curr Biol 13,
1435-1441.
Grebe, M., Xu, J., Mobius, W., Ueda, T., Nakano, A., Geuze, H.J., Rook, M.B. and
Scheres, B. (2003) Arabidopsis endocytic sterol trafficking involves actin-dependent
transport via Rab5-positive early endosomes. Eur J Cell Biol 82, 112-112.
Grebe, M., Xu, J., Mobius, W., Ueda, T., Nakano, A., Geuze, H.J., Rook, M.B. and
Scheres, B. (2003) Arabidopsis sterol endocytosis involves actin-mediated trafficking via
ARA6-positive early endosomes. Curr Biol 13, 1378-1387.
Grebe, M., Xu, J. and Scheres, B. (2001) Cell axiality and polarity in plants–adding
pieces to the puzzle. Curr Opin Plant Biol 4, 520-526.
Yang, W.C., Ye, D., Xu, J. and Sundaresan, V. (1999) The SPOROCYTELESS gene of
arabidopsis is required for initiation of sporogenesis and encodes a novel nuclear protein.
Genes Dev 13, 2108-2117.
* Co-correspondence authors
Invited Book Chapters:
• Xu, J. (2012) Plant root: structure, development and physiological function. In Plant
Physiology and Molecular Biology (4th ed., Chen, X.Y. and Xue, H.W. eds). Higher
Education Press. (in Chinese)
• Xu, J. (2012) Hormonal control of root development. In Plant Hormones: Function and
Molecular Mechanism (Xu, Z.H. and Xue, H.W. eds). Shanghai Scientific & Technical
Publishers. (in Chinese)
• Xu, J. and Hong, J.H. (2013) Root Development. In Genetics and Genomics of Rice
(Zhang, Q. and Wing, R.A. eds). Springer Science.