Download What is the cancer

BIOC 401
Blood Sample To Detect Breast
Cancer
Cancer is actually a group of many related
diseases that all have to do with cells. Cells
are the very small units that make up all
living things, including the human body.
There are billions of cells in each person's
body.
Cancer cells usually group or clump together to
form tumors. A growing tumor becomes a lump
of cancer cells that can destroy the normal cells
around the tumor and damage the body's
healthy tissues. This can make someone very
sick.
Sometimes cancer cells break away from the original
tumor and travel to other areas of the body, where they
keep growing and can go on to form new tumors. This
is how cancer spreads.
More common types of cancer
Liver cancer Stomach cancer
Lung cancer
Breast cancer
Breast cancer is a malignant tumor that starts
from cells of the breast. A malignant tumor is a
group of cancer cells that may invade
surrounding tissues or spread to distant areas of
the body .
Most breast cancers begin
in the cells that line the
ducts (ductal cancers).
Some begin in the cells
that line the lobules
(lobular cancers), while a
small number start in
other tissues.
There are to kind of breast cancer
Benign Breast cancer
Malignant Breast cancer
How To Detect Breast Cancer ??
Currently, doctors rely on triple testing :
breast examination, imaging with
mammography and ultrasonography, and
biopsy - to pick up these tumors.
Mammogram or Ultrasound
Biopsy
To check the lump
Comes specimens for
laboratory
Many analysis done in the patient
sample like hormone and protein
Blood plasma is an easily accessible source
of proteins which have diagnostic value,
as it is in contact with
practically all tissues in the human body.
There are many protein in plasma was
marker for breast cancer in patient .
Protein ??
This there protein marker for
breast cancer
Ca 15-3
Ca 19-1
Ca 125 ll
Elecsys is
machine
detect the protein
in plasma
Ca 15-3 , ca 19-1 ,
ca 125ll
A new study by researchers from University
College London says a simple blood test may
detect breast cancer early before it shows up
on a mammogram.

Unlike mammograms, which give false positives 10% of the
time and false negatives about 20% of the time.

The blood test measures proteins in the blood and may
detect changes in the levels caused by cancer.

The method analyzes specific proteins and these proteins
tell us what is going on with the patient in terms of the
disease and how the disease is playing out on the patient.
Protein
Secreted by breast tumor cells
This gene, which was named mammaglobin,
encodes a protein of 93 amino acid units with
a predicted molecular mass of 10.5 kd.
Mammaglobin is a member of the
uteroglobin gene family

School of Medicine researchers have shown that
mammaglobin, a protein secreted by breast tumor cells,
can readily be detected in the blood serum of patients
with metastatic breast cancer using an inexpensive,
reliable clinical test.

They have tested this technique on 56 women without
breast cancer and 26 women with metastatic breast
cancer .

The results showed that women without breast cancer
were found to have a steady, low level of mammaglobin
in their blood.

This baseline level was not affected by age, body mass
index, menopausal status, race, smoking history or a
family history of breast cancer.

the women with metastatic breast cancer had on average
much higher readings of mammaglobin than the baseline
level.

Compared to the few other known biomarkers linked to
breast cancer, mammaglobin is the best. The protein is
found in breast tissue and is secreted by most breast
tumors."

This technique, less intrusive, safer and much less
expensive approaches for the early diagnosis of cancer,
for distinguishing malignant and benign cancers, and for
monitoring cancer therapy.
City
Ratio
Alshrgeah
Riyadh
Makkah
Tabuk
22 %
17.5 %
13 %
7%
Qassim.
4%
More than 40% of Saudi women living with breast cancer
do not detect the disease only in very advanced stages of
the third stage.
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http://record.wustl.edu/news/page/normal/6133.html
http://news.bbc.co.uk/1/hi/health/5244764.stm
http://cancer.about.com/b/2006/08/06/new-blood-test-may-help-detectbreast-cancer-early.htm
h http://www.breastcancer.org/
http://www.breastcancer.org/
http://www.cancer.org/docroot/CRI/content/CRI_2_6x_How_to_perform
_a_breast_self_exam_5.asp
http://www.patentstorm.us/patents/5922836/description.html
http://www.patentstorm.us/patents/5922836/description.html
http://images.google.com/images?ndsp=18&um=1&hl=ar&rls=CYBA,CYB
A:2008-49,CYBA:en&q=lab+biochemistry&start=126&sa=N
http://www.breastcancer.org/symptoms/testing/self_exam/bse_steps.jsp
http://www.newson6.com/Global/story.asp?S=8802077&Call
=Email&Format=HTML
Wafaa Bokhary
Amera Al malki
Amjad Alsalmi
Mezna Albogami
0523687
0523527
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