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Respiratory System II • The Mechanics of Respiration - Review • Pulmonary Volumes - Spirometry • Exchange of Gases - Pressure of Gases • Regulation of Respiration • Acid-Base Balance Trachea C-shaped cartilage rings of trachea Before After swallow During swallow Food Esophagus Cervical vertebra Respiratory cycle Inspiration Compliance Expiration Elastic recoil Some videos http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=40 743 animation of diaphragm movement http://www.youtube.com/watch?v=xmceP5z6qsA&feature =related shows lung (cows) inflation http://library.med.utah.edu/WebPath/ORGAN.html#2 shows organ system pathology Lung Capacity The amount of air that can be expelled with the most forceful expiration The amount of air The amount of air in that remains in the the deepest lungs at all times inhalation followed by the most forceful The amount of air expiration in one normal in and out The amount of air in and out in one minute The sum of tidal volume, inspiratory reserve and expiratory reserve. 1. Tidal volume 2. Minute respiratory volume 3. Inspiratory reserve 4. Expiratory reserve 5. Vital capacity 6. Residual air The amount of air that can be taken in with the deepest possible breath Dead Space •Anatomical Dead Space - normal - contains air left in the inactive parts of the respirator tract •Physiological Dead Space - not normal, not good - nonfunctioning areas, may or may not contain air Testing Respiratory volumes http://www.intelitool.com/spirometry/Spirometry.h tm Partial Pressure of Gases • This law was discovered by John Dalton in 1801: you have a certain amount of gas present (choose a gas) if you double the amount of (gas) present then it also doubles the pressure - make sense! If the gas you added was a different gas (choose a different gas) then the pressure doubles, but each gas contribute only 50% of the pressure Therefore, each gas has a partial pressure now for the numbers First let’s review diffusion: going from a greater concentration to a lesser concentration The air you breath in (atmospheric air) is approximately 21% oxygen, 0.04% carbon dioxide (look at the chart on page 355 of your textbook) When it gets to the lungs (alveolar sacs) it diffuses into the blood (alveolar arterial capillaries) because of the concentration difference The air you breath out is approximately 16% oxygen, 4.5% carbon dioxide (reference page 354) Regulation of Respiration • Nervous system and chemical work together to cause the muscle movements of respiration respiratory center is in the medulla and pons of the brain http://www.columbia.edu/cu/psychology/courses/1010/mangels/neuro/anatomy/str ucture.html The impulses from the brain tell the lungs to inflate, until baroreceptors send a message back to the brain to stop the inflation. Then the muscles relax and we exhale Baroreceptors are nervous system receptors sensitive to pressure Chemical regulation • Chemical regulation of breathing refers to the pH of blood and the oxygen/carbon dioxide levels in blood Chemoreceptors detect changes of gases in the blood and pH If the chemoreceptors detect low oxygen, the respiratory ratechemoreceptors goes up detect chemicals If the chemoreceptors detect high carbon dioxide levels, the respiratory rate goes up Refer to page 360 and figure 15-10 Acid base balance • Taps and Drains pH is a scale for measuring acid and base/alkaline levels. The blood’s pH must remain between 7.35 and 7.45 The body’s goal is a constant balance between incoming/produced acids and bases (tap on) and eliminated acids and bases (drain open). Imbalances lead to acidosis (acid sink overflow) or alkalosis (base sink overflow). Balance can be restored by increasing elimination (faster draining) and/or by decreasing flow (slowing down the dripping tap). Acidosis and alkalosis Respiratory acidosis - respiration decreases causing an increase of carbon dioxide in body fluids Respiratory alkalosis - respiration increases causing a decrease of carbon dioxide body fluids Metabolic acidosis & alkalosis - When the above situations are from reasons other than the respiratory