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BIOLOGICAL PSYCHOLOGY: UNIT 2 Bio key assumptions 1) The importance of genetic influences on behaviour: The physiological approach see us as being to a large extent who and what we are by the genes inherited from our parents. We inherit 50% of our genes from our mother and 50% from our father. The more closely related two people are the more likely they will share the same characteristics (e.g. IQ, height, schizophrenia etc). A person has their ‘nature’ which is given to them by their genes, and a ‘nurture’ which is given to them by their environment. 2) The role of neurotransmitters on behaviour: The central nervous system consists of our brain and spinal cord. The automatic nervous system (ANS) which controls functions of the body such as the heart, lungs etc, which we have no conscious control. The Peripheral nervous system (PNS) controls those parts of the body to which we have conscious control such as flexing muscles. The brain guides behaviour through neurotransmitter functioning. 3) Brain Structure and behaviour: The brain has many parts, hippocampus is thought to be where STM occurs, and the hypothalamus produces hormones that influences gender during pregnancy. The brain is in 2 halves, joined by a mass of bundles called the corpus callosum. Brain lateralisation is the term used for considering the two halves of the brain separately and studies have shown that males and females use these hemispheres differently The central nervous system Our nervous system is activated when we receive a stimulus from the environment and respond to it, the messages are transmitted by a series of electrical impulses through nerve cells. Neurotransmitters are chemical messengers that travel in the brain between neurons. An electrical impulse travels down the axon and releases the neurotransmitter into the synaptic gap The receptors on the nearby dendrite receives the neurotransmitter if it ‘fits’ or not. (lock and key) If it is not taken up the message is stopped If it is taken up the message continues to travel down that neuron’s axon so the message continues Key definitions recap Central Nervous System (CNS) consists of the brain and the spinal chord and controls much of our behaviour by passing electrical impulses around the body through nerve fibres made up of tracts of neurones. Neurones are tiny nerve cells that communicate messages in the brain and around the rest of the body through impulses passed around the nervous system via synapses. A synapse is a junction between two neurones where messages are passed from one neurone to another. These messages are passed through neurotransmitters which move from the terminal button of one neurone, to the receptors on the dendrite of another neurone. Neurotransmitters are chemicals that are released by neurones into the synaptic gap. Receptors (protein molecules situated on the membrane of the neurone) on adjacent neurones allow the neurotransmitter to attach to them if the neurotransmitter is the right shape to fit that particular receptor. This then changes the chemical makeup of the neurone and therefore its voltage causing an electric charge to pass down the axon of the neurone (called an action potential). When the charge gets to the terminal buttons at the bottom of the axon it causes neurotransmitters held within that neurone to be released into the synapse. A Hormone is a chemical which is released from a gland, travels in the blood and affects target organs such as muscles, sex organs or other glands. For example sex hormones, such as oestrogen and testosterone are released by the gonads (sex organs). Oestrogen is produced by the ovaries in sexually mature females and testosterone is produced by the testes in sexually mature males (although a little of each is produced by both sexes). These hormones are responsible for many of the changes that occur around puberty such as the deepening of the voice in males and the onset of menstruation in females. Brain lateralisation refers to the uneven distribution of tasks carried out by the hemispheres. Lateral means side. Any function, e.g. language, which is found on one side of the brain is called a lateralised function Genes are units of information that are inherited from our parents. They control, or influence characteristics such as risk of mental health disorders, personality and sexual development. Genes are sections of strands of a chemical called DNA found in our cells. METHODOLOGY Twin and Adoption Studies Both these methods are designed to separate nature from nurture. Twin studies change the genes and keep the environment steady, whereas adoption studies keep the genes steady and change the environment. Twin Studies Twin studies are a research design which involve comparing identical (MZ) and non identical twins (DZ) in order to determine the importance of genes and the environment on individual traits and behaviours. Twin studies compare the amount of behavioural similarity between two types of twins – monozygotic twins and dizygotic twins Monozygotic (MZ) twins are genetically identical as they both developed from the same egg. Dizygotic (DZ) twins only share 50% genes so are as genetically related as ordinary siblings. Both types of twin will however share very similar environments as are born at the same time to the same family so will be treated the same. Any differences in the amount of behavioural similarity shared by each type of twin must therefore be due to the difference in genetic makeup. So if the behaviour of MZ twins is more similar than the behaviour of DZ twins we assume it is because they are genetically identical and therefore behaviour is a product of nature, not nurture. An example of twin studies is research into schizophrenia which has found that monozygotic twins have a higher concordance rate of schizophrenia than dizygotic twins suggesting that schizophrenia must have a genetic element. Sometimes MZ twins are separated at birth and raised in different environments. They can be traced and tested for behavioural similarities to each other. Similar behaviour is therefore likely to be due to genetic influences. These cases though are quite rare. Evaluation of Twin A strength of twin studies is that they provide a good natural experiment as nurture is kept constant whilst genetic makeup varies so any differences between twins can credibly be assumed to be due to nature. For example monozygotic twins have been found to have a higher concordance rate for schizophrenia than dizygotic twins which clearly shows that schizophrenia does have a genetic element. A further strength of twin studies is that twin studies are highly true to life as nothing in the environment is directly manipulated. The findings are naturally occurring and we can therefore generalise the findings to their real situations as they are not artificial. Furthermore, twin studies often collect a lot of data which is usually both quantitative and qualitative. A weakness of twin studies is that they may suffer from a sampling bias. Twins used in research often answer advertisements, therefore they are a volunteer sample, meaning that they might only represent a certain type of person rather than be truly representative. A further weakness of twin studies is that MZ twins, because they look the same, are in fact treated more like each other than DZ twins who don’t look the same, therefore MZ may have more similar environments too making it hard to draw conclusions about the role of nature and nurture. Adoption studies An adoption study tracks the behaviour of children adopted away from their biological parents at a young age. It looks for similarities between the child and their biological parents and their adoptive parents. If adoptive children are more like their biological parents then we attribute the behaviour to nature – it is in the genes, but if they are more similar to their adoptive parents then it is due to nurture. Evaluation A strength of adoption studies is that these studies tend to be quite ethical because there is no direct manipulation of the participants. The adoption occurs naturally so the psychologists simply track and measure behaviour. A further strength of adoption studies is that adoption studies are highly true to life as nothing in the environment is directly manipulated by the psychologists. The findings are naturally occurring and we can therefore generalise the findings to other real situations as they are not artificial. Furthermore, adoption studies often collect a lot of data which is usually both quantitative and qualitative. A weakness of adoption studies is that in practise adoption agencies try and place children with families similar to their birth family; this means that there is not a complete change of nurture, so it may overestimate the role of nature in causing any similarities between the children and their birth parents. A further weakness of adoption studies is that they may suffer from a sampling bias. Adopted participants used in research often answer advertisements, therefore they are a volunteer sample, meaning that they might only represent a certain type of person rather than be truly representative. PET and MRI Scanning Techniques Brain scanning techniques are a major advance in biological psychology. They allow researchers to examine the brains of living people and draw conclusions about the relationship between brain structure/activity and behaviour. There are two basic types of scan: functional e.g. PET and structural e.g. MRI. Structural scans take detailed pictures of the structure of the brain and functional ones show activity levels. Magnetic Resonance Imaging (MRI) Scans • • • • • These are a form of structural scan that shows a picture of the brain inside the skull so that specialists can identify any areas of damage or tumours. They allow a real, living brain to be seen without having to cut into the head of the patient. Patients are placed in a very large scanner that sends a strong magnetic field through their head. The magnetic field causes the nuclei in hydrogen molecules in the brain to spin in a particular way, and this is picked up by the scanner. Because hydrogen concentrations vary in different parts of the brain, it is possible for the scanner to produce a detailed image of the brain based on the amount of hydrogen molecules it identifies in different areas. Positron Emission Tomography (PET) Scans • • • PET scans are functional scans that show images that can illustrate how the brain is working during different tasks. By identifying areas that are not working properly, doctors can see areas that are damaged or areas affected by tumours. Patients are injected with water or glucose that has been labelled with a radioactive tracer substance. The substance travels around the body until it reaches the brain where the brain uses up the water or glucose as energy and the tracer begins to decay. As the tracer decays, it gives off positrons, so the more energy being used in different areas, the more positrons are being emitted. The positrons collide with electrons and form gamma rays that are picked up by the scanner and show the amount of energy being used by different areas of the brain Using animals in experiments Describe Animals are used in a number of areas of study (language, memory and learning) in particular how the brain works and the effects of genes. Laboratory experiments with animal subjects are essentially the same as with human participants. An independent variable is manipulated in one condition and its effect is measured on the dependent variable and compared to the dependent variable in other conditions in order to establish cause and effect. All other variables are controlled and held constant across the conditions. Animals are used when the independent variable is invasive and it would be unethical to apply it to humans e.g. administering a drug to see its effect on behaviour or to gain the maximum control over variables other than the independent variable/dependent variable e.g. animals can have all aspects of their lives controlled for the purpose of the experiment and you can breed animals for the experiment that are genetically similar so as you can remove the chance of individual differences affecting the results Consider, ethics, practical issues and credibility. (Pavlov’s dogs and Skinner’s superstitious pigeons are good examples to use) Using animals in experiments Evaluate PRACTICAL ISSUES FOR Small and easy to handle Short reproductive cycles Similar brain structure to humans Short lifespan Strict control of procedures AGAINST Brains are not going to be identical to humans Genetic structures are not the same Human lives are complex Some diseases have to be replicated in animals using drugs and so might not be the same thing ETHICAL ISSUES REASONS WHY possible to carry out some procedures that you cant do on humans (Cutting/damaging parts of the brain) should protect humans first, animals come second Drugs have been developed that could not have been developed otherwise - treatments Knowledge obtained helps animals as well as humans GUIDELINES 3R’s Bateson Cube A – Anaesthetic given N – non animal expts cant be used I – important enough to justify? M – minimum used A – appropriate accommodation L – legislation followed S – specialist and competent staff CREDIBILITY SUBJECTIVE Does the data make sense to draw conclusions from animals to humans? Using animals can be seen as lacking credibility because people think that animals are too different to humans for the results to apply OBJECTIVE How strong is the data in respect of how good the methodology is. Using animals is scientific because there can be controls and studies can be repeated to make sure the findings are reliable. KEY STUDIES Money 1975 Aims: Wanted to find out about sex reassignment Case Background/procedure: looked at an MZ boy (David Reimer) brought up as a girl after a circumcision went wrong Case Description: The baby’s penis was burnt off accidentally because the electric current was too strong. The parents contacted Money and chose to go for sex reassignment. They treated ‘Brenda’ as a girl and encouraged her to be socialized in female role. Hormone replacement therapy and surgery was used as child developed. ‘Brenda’ was reported to have tomboy traits and being physically active. Could you add any specifics in here? Case analysis: Money concluded that a normal XY baby could be successfully nurtured as a girl and therefore stronger than nature. ‘Brenda’ was told the whole story at 15yrs and it emerged that she was never happy as a girl. His mother attempted suicide and his father turned to alcohol. His brother became clinically depressed so the family was under enormous pressure. ‘Brenda’ underwent surgery, was depressed and attempted suicide himself. However, he married and had a job. His brother died of an overdose and David had marital problems and eventually committed suicide. Money Evaluation Strengths: V - Case is detailed and longitudinal giving it validity. Qualitative data from various sources Observation, questionnaires and interviews from parents as well as Brenda’s self report. G - This was a real-life case that was reported by Money so it has high ecological validity because the boy’s life and the events that happened to him were all real. A – due to the type of twin study it was it provided a unique opportunity to test the effects of nature versus nurture on gender development due to the matched control of a genetically identical twin. This meant that it was possible to compare the gender identity of the two boys who had identical genetic make-up but were brought up differently. Weakness: G - Hard to generalise as unique case. R - David was not typical of other children in a number of ways. For example David had an identical twin brother which may have also influenced his gender behaviour and his identical twin brother suffered from schizophrenia which it is believed is partly caused by genes V - David was not happy as a girl so no validity V / R - Concerns the subjectivity and bias of the psychologist carrying out the study. It is very possible that Money interpreted the findings as to fit in with his gender neutrality theory. It is argued that behaviour of the twins was misreported by Money who claimed that the study was successful in the reassignment of Bruce’s gender. David’s later testimony does suggest that Money’s was bias and misreported the findings E - ethical issues surround this case study. The twins were allegedly encouraged to pose naked in sexual positions which they said was degrading Being involved in the case study was alleged to have been a factor in the mental break down of Brian Reimer, and the later suicide of David. It has been argued that Money coerced Bruce’s parents into allowing him to study the case and that the study’s reported findings were manipulated by Money for his own gain and the potential effect on the children was ignored. Raine 1997 A: Wanted to find out about brain differences between murderers pleading NGRI and nonmurderers. P: Sample and Design: 41 murderers charged with manslaughter. 23 had history of brain damage, 6 with schizophrenia, 3 with substance abuse, 2 with mood disorder, 2 with epilepsy , 3 with learning disability and 2 with paranoid personality. The control group was matched for these features. The study took place in a University in USA. IV = whether participant was a murderer or not DV = various measures of brain activity Each PPt carried out a practice test and then injected with a trace, then given more tests. After ½ hr a PET scan was taken. Slices of the scan were checked for glucose levels and compared with the controls. R: murderers had lower glucose metabolism in some prefrontal areas. There were no differences in the temporal lobe. The murderers had lower glucose in the corpus callosum and had different levels of activity in the area of the brain linked to aggression C: murderers have lower glucose activity levels and abnormal activity in other areas. Suggest biological cause. Could not conclude biological cause for violence just a predisposition for it depending on the environmental triggers (nurture). Raine Evaluation Strengths: R – High amount of control - For example they used a control group who were matched on variables such as age and sex and they were screened for their physical and mental health. Such standardised procedures allow for replicability and further studies have been carried out by Raine gaining similar results therefore improving the reliability of the findings V / R - PET scans allow for a wide range of non intrusive studies and importantly provide a large amount of quantitative and objective measures of brain activity from which sophisticated analysis can be complete G - Sample size is large enough for generalisation to murderers pleading NGRI Weakness: A / V - natural experiment, which means that the researchers could not randomly allocate participants to either of the two conditions. Therefore we have to be careful in making cause and effect statements. It is possible that any differences in brain activity between the two groups could have been caused by other factors. We can only say that the study shows a correlation and not a causal relationship. For example, it could be that the differences between the two groups might have been a result of the crime and its consequences rather than a cause of it. V - PET scans cannot give us valid or subjective data about how a person is actually thinking. Although we can see an objective measure of murderers brain activity we do not know what they are thinking. We have to infer the thought patterns from different levels of activity in different parts of the brain G - the task used by the participants before the scan is a general activity task and has no bearing on violent acts or even the decision to be violent – lacks mundane realism Lab study lacks ecological validity especially when considering the environment when they committed their crime Also there were no violent criminals in control group so hard to generalise beyond study GENDER DEVELOPMENT SEX DIFFERENTIATION Gender= social term that refers to the norms and rules of being male or female Sex = biological term that refers to our genetic sex, male or female. We have 23 pairs of chromosomes, each pair comes from our mother or father. (50%) a male baby receives (XY) and female (XX). An embryo generates hormones within 8 weeks. The hormones influence the sex of the baby. Hormones also carry messages and are produced by the endocrine gland. They travel in the blood and are a lot slower than neurotransmitters. Sex differentiation goes through 4 steps 1. Fertilization determines the genetic sex (XX) or (XY) 2. During development the sex organs grow and a gonadal ridge develops. External genitalia look female. 3. Hormones (androgens) start affecting how the fetus develops Testosterone andinandrogens FEMALES: and progesterone 4.MALES: The gonadal ridge changes, males testes are developed, Oestrogen in females ovaries develop BRAIN LATERALISATION There are brain differences between males and females. The brain is divided into 2 hemispheres which are joined by the corpus callosum which is larger in women. The left half controls language and the right is concerned with visuospatial ability and perception. Evidence comes from scanning techniques: If male has damage to RH then visuospatial tasks are affected Men who do not have normal exposure to androgens tend to use both sides of the brain more High levels of testosterone means slower neuron growth in the LH which supports males using the RH more. Strengths of biological explanation of Weakness of biological explanation of gender development: + high reliability because studies are replicable. + Any experiment using animals or humans are objective and scientific. + There is validity because different studies use different research methods have similar findings. (MRI scans, lab expt etc.) gender development: - difficult to generalise because many findings come from animal studies. - There are important differences in the human brain so findings not credible. - Can’t ignore influence of the environment in behaviour KEY ISSUES The debate over whether transgender operations are ethical Outline of the issue A transgender operation involves changing the physical sex of a person, e.g. changing a male into a female physically This can be done with adults because they feel they are in the wrong sex body It can also be done on children if they appear to be of an indeterminate sex However in the case of children there are ethical issues as it is the parents not the child who decides what sex they become Some argue it isn’t ethical to spend public money on what could be seen as a non essential operation Application In the case of Money’s study at first it seemed that a male could successfully become a female However in David Reimer’s later testimony it was clear it didn’t work as he changed back to a male The case of Daphne Went would suggest it does work as she is biologically male but happy as a female If gender is partly due to brain lateralisation then such operations won’t work as the child will still have the original sex brain However social learning theorists would argue that with appropriate role models children can learn to be a specific sex A study of 14 males who were raised as girls after surgery found that most of them still felt male showing it often doesn’t work Is autism an extreme male brain condition? Description Autism affects a child’s ability to interact and build relationships with others Symptoms can include lower language abilities than others their age and problems with communicating Almost ¾ of people with autism are male It is thought that an autistic brain structure is an exaggeration of normal male brain structures Application Male brains are heavier than female brains, and people with autism have heavier brains In early development male brains grow faster than female brains and the brains of people with autism grow even faster Males are better at spatial tasks than females, and people with autism tend to be even better at them showing it could be due to brain function People with autism are slower than males who don’t have autism at developing language, with females developing language the fastest However hormones could play a part as it could be due to exposure to male hormones which explains why some females also have autism It may also be genetic as about 60% of MZ twins will have it if their twin already has it Bio Practical Aim: to investigate the difference in spatial skills abilities between males and females using a psychometric spatial skills test Background: Spatial ability is required in technical and design jobs where drawings and plans are used such as architecture, surveying, engineering and design. It is also important in our everyday lives for things such as parking a car and map reading. Some men have long held that women are deficient in these skills. Many women have disagreed! Spatial skill is the ability to assess and orientate shapes and spaces. More can be found in your “How Science Works” packs ? Could it be that spatial skills such as map reading and parking may be difficult for some women because they had too little testosterone in the womb? Some of you looked at gender differences others looked at length of ring and index finger. Ensure you have a hypothesis in relation to your study – italics below are dependent on which one you did Procedure Participants were approached in the class and asked if they would consent to take part in a study on spatial ability. Pps were briefed and gave verbal standardised instructions. Pps were then asked to stay quiet and given the spatial awareness task to complete. This consisted of a number of shape rotation tasks to see which shape matched a number of rotated alternatives. Pps were given 10 minutes to complete the test, which was timed. Participants were asked to write their sex – male/female on their answer sheet but not their name. They then examined their own ring finger to see if it was shorter/longer/the same as their index finger. This was also marked on the answer sheet. Pps answers were then scored and a total obtained for each pp. Can you answer these questions? What were the IVs? How was the DV measured? What sampling method was used? How many male pps were there? How many female pps were there? Who were your pps? Age range / occupation / target population. What is the research method? What is the research? (We completed the statistical test to get an observed (or calculated) value. If we are conducting a Mann Whitney U test it is called the U value. To know if this is significant, we need two pieces of information: 1.Did the study have a directional (one tailed) or non directional (two tailed) hypothesis? 2.How many _________________ are in each group. We call this N1 and N2 (N1 is usually the smaller group) Using this information, we compare our observed value (the one you calculate) with the critical value from the table. If the observed value is equal to or higher than the critical value, we accept the experimental hypothesis and reject the null hypothesis. If the results are not statistically significant then we accept the Null and reject the experimental hypothesis.(NB: if our result is significant, but in the opposite direction than that which we predicted, i.e. girls are better at spatial awareness tasks than boys then we still have to reject the experimental hypothesis). NB: If the number on the table of critical values is lower than U (your observed or calculated value), it is not significant. If the number on the table of critical values is equal to or higher than U, then the result is significant. Results: What where the results of your analysis. Calculated U (observed value)= _____ Critical value for significance at 0.05 = ___________ (directional hypothesis) Calculated U is greater/less than the critical value of U. Therefore this is/is not significant at 5% level. P≤/≥0.05. This means the probability of the results being a fluke is greater / less than 5%. This means we are/are not 95% sure that the IV had an effect on the DV. Conclusions: State your conclusions, including statements of significance relating to the hypothesis. The experimental results were/were not significant at the 5% level therefore the experimental hypothesis can be ____________ and the null hypothesis __________________. The results do not support/support the hypothesis that males perform better on spatial awareness tasks. Evaluation of Practical G - could refer to how far the sample represents the target population. As our hypothesis states that males perform better on spatial awareness tasks, then we would need to look at our sample to see if it is representative of males and females Who was the target population? Was there an equal distribution of males and females? Was the sample big enough for us to generalise our findings? Was there a wide range of ages sampled? Which sampling method was used (opportunity/self-selected samples) tend to be biased and therefore not representative R - refers to the extent to which a test or other instrument is consistent in its measures. The test we used is a well-established psychometric test, so we can say that it is reliable. A - can you think of why this research is useful? How could these type of findings be used? V - refers to whether a test is actually measuring what we think it’s measuring. We are using a shape rotation test to measure spatial ability. This is certainly part of what spatial ability is. However, how far does it relate to how people use their spatial ability in their everyday life? The setting was also not a natural one so the study lacks ............................... validity. A more valid way of measuring people’s spatial ability would be to: E – what did you consider??