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Milnacipran's Efficacy in Major Depression Efficacy vs SSRIs Meta-analysis of double-blind studies in moderate to severe depression Change in total HDRS score between baseline and endpoint HDRS Milnacipran SSRIs (n=150) (n=156) at baseline 27.0 26.5 at endpoint 11.9 14.3 -15.1* -12.2 ï at endpoint * p<0.05 Milnacipran : a superior improvement in HDRS score Lopez-Ibor J et al. Milnacipran and selective serotonin reuptake inhibitors in major depression. Int Clin Psychopharmacol 1996;11(Suppl 4):S41-S46. 52