Download Pharmacology II - 3-29

PHARMACOLOGY TUTORING –
FACTORS AFFECTING DRUG
ACTION
By Alaina Darby
[email protected]
Which of the following is not a drug metabolizing enzyme that can
influence pharmacogenomics?
a. CYPs
b. UGT
c. VKORC1
d. HLA-B*1502
Which of the following is true of infection as a factor affecting
absorption?
a. Causes chelation of some drugs
b. Causes alterations in GI transit time
c. Causes decreased weak acid absorption
d. Causes decreased weak base absorption
The plasma levels of which of the following drugs is increased with
OATP mutations?
a. Fexofenadine
b. Digoxin
c. Simvastatin
d. Nelfinavir
Which of the following is not true of competition for protein binding?
a. Consequences are dependent upon Vd
b. Consequences are dependent upon therapeutic index
c. There are many clinically relevant interactions
d. Sulfonamide competes with bilirubin to cause kernicterus
Which of the following is true of CYP induction and inhibition?
a. Inhibition usually causes long-lasting action
b. Induction is usually transient
c. Alcohol inhibits enzymes
d. Suicide inhibitors cause longer-lasting action
Which of the following might cause a toxicity that can be seen in a
patient?
a. Inducer increases drug concentration above therapeutic index
b. Inhibitor decreases drug concentration below therapeutic index
c. Inducer decreases drug concentration below therapeutic index
d. Inhibitor increases drug concentration above therapeutic index
Which of the following is an organic acid that can inhibit tubular
secretion?
a. Acetylcholine
b. Probenecid
c. Histamine
d. Quinine
Which of the following would be true when trying to decrease
streptomycin reabsorption?
a. NaHCO3 administered to increase urine pH
b. NaHCO3 administered to decrease urine pH
c. NH4Cl administered to increase urine pH
d. NH4Cl administered to decrease urine pH
Which of the following would cause competition at the receptor site
and antagonize the effects of the other?
a. Atropine and tubocurarine
b. Propranolol and morphine
c. Atropine and acetylcholine
d. Acetylcholine and neostigmine
Reduction of enzymatic activity would most greatly decrease the
efficacy of which of the following drugs?
a. Active drug with active metabolites
b. Active drug with inactive metabolites
c. Inactive drug with active metabolites
d. Inactive drug with inactive metabolites
Which of the following is true of clinical trials?
a. The strength of uncontrolled studies is to determine prognostic
effects of genetic markers
b. The strength of uncontrolled studies is to determine predictive
effects of genetic markers
c. The strength of controlled studies is to determine prognostic
effects of genetic markers
d. The strength of controlled studies is to determine predictive effects
of genetic markers
Which of the following can be used to closely model in-vivo systems
but only has a limited number of cells?
a. Recombinant drug metabolizing enzymes
b. Primary human cell lines
c. Immortalized human cell lines
d. Induced pluripotent cells from human blood
Which of the following is true of genome effects?
a. Irinotecan exerts toxic effects through mutations in UGT encoded
by the human genome
b. Irinotecan exerts toxic effects through mutations in UGT encoded
by the tumor genome
c. Gefitinib exerts toxic effects through mutations in EGFR encoded by
the human genome
d. Gefitinib exerts toxic effects through mutations in EGFR encoded by
the tumor genome
Which of the following pairs of enzymes are most indicative of
bleeding risk in warfarin therapy?
a. VOKRC1 and CYP3A4
b. VOKRC1 and CYP2C9
c. CYP2C9 and CYP4F2
d. CYP2C9 and CYP3A4
Which of the following is the most clinically relevant metabolite of
tamoxifen?
a. N-desmethyl-tamoxifen
b. 4-hydroxy-N-desmethyl-tamoxifen
c. 4-hydroxy-tamoxifen
d. N-didesmethyl-tamoxifen
Which of the following combinations of CYP’s can induce renal failure
in codeine administration?
a. Rapid CYP2D6 and rapid CYP3A4 metabolism
b. Rapid CYP2D6 and inhibited CYP3A4 metabolism
c. Inhibited CYP2D6 and rapid CYP3A4 metabolism
d. Inhibited CYP2D6 and inhibited CYP3A4 metabolism
Which of the following is not thought to contribute to contribute to
drug hypersensitivity reactions such as Stevens Johnsons Syndrome?
a. HLA alleles
b. Tyrosine kinase inhibition
c. Hapten-peptie complexes
d. T-cell receptors