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Increased use of Advanced Medical Imaging, Radiation Exposure, and Cancer Risk Diana L. Miglioretti, PhD Group Health Research Institute Rebecca Smith-Bindman, MD University of California, San Francisco May 31, 2011 | D. Miglioretti, PhD Outline Background • Utilization of medical imaging • Cancer risk from radiation • Radiation from medical imaging Study of dose from CT at 4 San Francisco Bay Area Facilities • Dose from CT is high and variable Study of imaging at 7 integrated healthcare systems • Imaging utilization and radiation exposure • CT use in children • Radiation exposure from CT in children • Leukemia risk Discussion & Conclusions Benefits of Medical Imaging Earlier and more accurate diagnosis of disease • Earlier treatment • Improved patient outcomes Quick diagnosis (e.g., CT use in ED) Less invasive diagnosis Accurate prognosis Reassurance Harms Associated with Imaging Radiation exposure Doses of common exams (e.g., CT) in carcinogenic range Rare - accidental overdose False positives – Unnecessary follow-up testing, anxiety, cost Incidental findings – Cascade of testing to rule out disease Overdiagnosis – Unnecessary treatment Contrast reactions – Most minor, some major Healthcare costs Advanced imaging is expensive 2008 CT and MRI use tripled in 10 years Radiation and Cancer Risk Measures of Radiation Exposure Effective dose (ED) • Estimates a patient’s overall exposure from non-uniform radiation like medical imaging • Accounts for • amount of radiation from machine • body part irradiated (sensitivity of organs to radiation) • patient’s age and possibly gender • Reflects sensitivity to developing cancer from radiation exposure • Younger children more sensitive to radiation • Some organs more sensitive to radiation • Expressed in milliSieverts (mSv) BEIR VII Report The U.S. National Academies of Sciences Biological Effects of Ionizing Radiation Committee (BEIR) conducted a comprehensive review of literature on health risks of low dose radiation exposure Members included leading scientists from a broad range of disciplines Estimated cancer risk based on dose and age at exposure using a variety of studies Japanese Atomic Bomb Survivors Life Span Study of the 120,000 survivors of the atomic bombings in Hiroshima and Nagasaki Japan The median dose of survivors was 40 mSv Organ specific radiation doses are linked with organ specific cancers for nearly every cancer Even at low doses (10 mSv), survivors were at a significantly increased risk of developing cancer Medically Irradiated Populations Malignant Disease Following radiotherapy for malignant disease, there is an elevated risk of second cancers Second primary malignancies particularly high among survivors of childhood cancer Among Hodgkin’s survivors, radiation-induced second primary cancers are a leading cause of mortality Medically Irradiated Populations Benign Disease Radiation commonly used 1930-1960 for benign conditions • Tinea capitis • Enlarged tonsils • Enlarged thymus • Breast conditions (i.e., post partum mastitis) Increased risks of radiosensitive cancers • thyroid, salivary gland, central nervous system, skin, and breast Medically Irradiated Populations Repeated X-rays Studies have assessed groups who received repeated radiographs • Scoliosis • Tuberculosis • Children with cardiac catheterizations All significantly more likely to develop cancer Radiation Workers 400,000 radiation workers in the nuclear industry Average doses of 20 mSv Significant association between exposure (5 - 150 mSv) and cancer mortality Ongoing studies of radiology technologists, physicians who use radiation suggest increase cancer risks Summary of Evidence of Harmful Effects of Radiation A large body of epidemiological and biologic evidence links exposure to radiation (even low doses) with development of cancer The results are highly consistent across studies “It has not been scientifically demonstrated that any cancer risk exists below 100 mSv” is untrue The A-bomb survivor data provides best dose response data • However, the effect size is consistent across studies Radiation Exposure from Medical Imaging Imaging Studies Associated with Radiation Nuclear Medicine (25% of cumulative dose) • Radioactive material is inhaled, injected, or swallowed • Gamma rays are emitted by the nuclei, and detected energy is collected and displayed on a computer X-Rays (75% of cumulative dose) • X-rays are generated by a machine, pass through patient to form pictures on film / computer screen • Radiographs, fluroscopy, angiography, interventional procedures = 10% of dose • CT = 65% of dose Medical Radiation The risks associated with ionizing radiation are not new • Many of the radiology pioneers developed burns or died from radiation-induced cancers What is new is the dramatic increase in exposures to ionizing radiation from CT Radiation Exposure of US Public Has Doubled Due to Medical Imaging 1985: total 3.7 mSv 75% from natural sources 25% imaging 2006: total 6.2 mSv 50% from natural sources 50% imaging Sample Annual Radiation Exposures Source mSv Radon 2.0 Living in Denver 0.63 Food 0.40 Sun exposure 0.27 Dental radiographs (series) 0.05 Jet travel (6 hours) 0.03 Airport screening 0.00001 Chest radiographs (PA & Lat) 0.06 CT chest 8.0 CT head, chest, abdomen, pelvis 35-100 Radiation Doses of Common Imaging Tests Source mSv Chest radiographs (PA & Lat) 0.06 Mammogram series, film-screen 0.80 IVP 2.5 GU contrast studies 1–4 Nuclear medicine renal 2–3 CT head 2.0 CT chest 8.0 CT abdomen & pelvis 12.0 Coronary angiogram 4.6 – 15.8 Nuclear medicine heart 8.9 – 17.0 Radiation Doses from CT: High, Variable, and Potentially Harmful Study of four facilities in San Fran Bay Area • Smith-Bindman et al., Arch Intern Med, 2009 • Adults, median age 59 years • January 1 – May 30, 2008 Dose from CT 1.5-5 times higher than widely cited • Higher than needed for medical diagnosis Doses highly variable for same test and indication • Vary 15-20 times among facilities • Even greater variation among patients (even at same facility) • Expect ~2-fold variation due to differences in body size Effective Dose for Common CT Types: Variation within Imaged Region Typically Reported Doses (mSv) Mean Effective Dose (mSv) Equivalent No. of Chest Radiographs Equivalent No. of Mammograms Routine head 2 30 5 Suspected stroke 14 199 33 Routine chest 8 118 20 Suspected pulmonary embolism 10 137 23 Coronary angiogram 22 309 51 Routine 15 234 39 Multiphase 31 442 74 2–3 Head Chest 7 Abdomen-pelvis 8 – 10 Smith-Bindman et al., Arch Intern Med, 2009 Effective Dose for Common CT Types: Variation across Facilities and Patients Site 1 Site 2 Site 3 Site 4 Range Across Patients Head Routine head 3 2 3 2 0.3 – 6 Suspected stroke 18 15 8 29 4 – 56 Routine chest 6 12 11 7 2 – 24 Suspected PE 8 21 9 9 2 – 30 Coronary angiogram 21 20 Routine 12 19 20 12 4 – 45 Multiphase 24 35 45 34 6 – 90 Chest 7 – 39 Abdomen-pelvis Smith-Bindman et al., Arch Intern Med, 2009 Radiation exposure varies among and within CT types Smith-Bindman et al., Arch Intern Med, 2009 Radiation exposure varies among and within CT types Smith-Bindman et al., Arch Intern Med, 2009 Average exposure among Japanese atomic bomb survivors Why are doses so high and variable? No clear dose targets for CT in US No professional or governmental organization responsible for collecting and reporting dose data Few clear standards Lack of knowledge about dose levels among physicians and technologists • May be changing Technical improvements in CT have ironically led to increasingly high doses for more exams Cancer Risks are Not Trivial Smith-Bindman et al., Arch Intern Med, 2009 Cancer Risks are Not Trivial Smith-Bindman et al., Arch Intern Med, 2009 If 1000 20 year old women undergo a multi-phase abdomen and pelvis CT, 4 are estimated to develop cancer from the test (range in estimate 2- 12) Image Utilization Study of Imaging Use Retrospective observational study 7 integrated healthcare systems 1994-2007 [adding data through 2010] 2.5 million members each year Study Sites Increase in CT Use CT use by Age and Year Contributions of Imaging Tests to Rate of Testing and Radiation Exposure Imaging Exams per 1000 enrollees N, % 1994 Total Radiation Exposure per 1000 enrollees mSv, % 2007 1994 2007 Angiography + Fluroscopy 66 7% 66 4% 408 35% 357 13% CT 47 5% 197 12% 342 30% 1,662 61% MRI 18 2% 89 6% Nuclear Medicine 22 2% 65 4% 136 12% 411 15% Radiographs 704 70% 880 55% 271 23% 311 11% Ultrasound 153 15% 294 18% Annual (Cumulative) Effective Dose 1% 10% Median For each patient, each year, we summed radiation form all imaging examinations and described the distribution in dose among those with the highest annual exposure Summary of Results A quadrupling in CT • From 47 to 197/1000 enrollees per year • 10% annual growth Similar increases for other imaging modalities • Quadrupling in MRI • Doubling in ultrasounds and nuclear medicine • No decrease in radiographs Annual imaging costs increased three-fold and by 2007 averaged ~$300 per person per year. • Half of costs from CT and MRI Preliminary results from 2008-2010 shows rates may be starting to plateau or possibly even coming down Summary of Results In 1994, CT accounted for 5% of imaging and 30% of radiation exposure In 2007, CT accounted for 12% of imaging and 61% of radiation exposure In 2007, ~ 7% of enrollees received an annual radiation exposure of 10 mSv or higher Pediatric Imaging Study of Imaging Use Retrospective observational study 7 integrated healthcare systems 1994-2010 (some sites only until 2007) Ages 14 years or younger 169,000 – 511,000 children per year Study Sites 20 07 5 20 06 10 20 05 20 04 20 03 20 02 20 01 20 00 19 99 19 98 19 97 19 96 19 95 19 94 Rate per 1,000 children CT use in Children 35 30 25 20 15 <1 year 1-4 years 5-14 years 0 Body Areas Imaged with CT 1994 100% 2007 0% 100% 5% 14% 80% 3% 17% 80% 6% 8% 7% 4% 20% 40% 60% 60% 100% 40% 76% 71% 40% 65% 20% 20% 0% 0% < 1 year 1-4 years 5-14 years 79% 47% < 1 year 1-4 years 5-14 years Other Extremity Spine Chest Abdomen Head Radiation Doses from Common CTs Data abstracted on 1,266 exams from three sites: • Group Health Cooperative, Washington • Kaiser Permanente Hawaii • Kaiser Permanente North West, Oregon Sample • 1994-2008 - One site collected additional data from 2009-2010 • Ages < 1 year – 30 years Randomly selected CT exams performed on: • Head (brain, face, orbit) • Abdomen/Pelvis • Chest • Spine or Neck Abstracted dose values from all CTs on same child on same day Calculation of Effective and Bone Marrow Doses and Leukemia Risk Doses calculated by Choonsik Lee PhD, Investigator, Radiation Epidemiology Branch, NCI Developed improved methods • Multiple phantom sizes • Newborn, 1, 5, 10, 15, adult • Male and female representing 50th percentile body size • Improved phantom anatomy and skeleton dosimetry method Organ doses estimated from a precalculated dose matrix covering whole body with a series of continuous axial slices of 1cm thickness. Hybrid phantom series coupled with Monte Carlo modeling of Siemens sensation 16 were used to generate the precalculated dose matrix. Machine-specific CTDIw used to convert Siemens sensation 16 dose to other machines. Estimated RR of death from leukemia 5 years after exam, based on bone marrow dose (based on BEIR VII) Relative Risk of Leukemia Death 5 years after CT Exam Number of CTs Min 5th 25th 50th 75th 95th Max ≥ 2.0 ≥ 3.0 < 1 year 87 1.1 1.2 1.4 1.6 2.0 2.6 3.8 24.0% 3.4% 1 year 52 1.1 1.1 1.3 1.5 1.8 2.5 2.7 9.6% 0% 2 – 4 years 144 1.1 1.1 1.2 1.3 1.5 2.0 2.6 5.6% 0% 5 – 9 years 246 1.0 1.0 1.1 1.2 1.3 1.5 2.2 0.8% 0% 10 – 14 years 308 1.0 1.0 1.0 1.1 1.1 1.2 1.8 0% 0% Age Group Summary of Pediatric Imaging CT use quintupled: from 11 to 52 CTs / 1,000 children per year Doses decreased until 2002, then in 2005, increased • May be coming back down Doses and cancer risk higher for infants and toddlers • Over 10% of children 4 years or younger received an effective dose of ≥20mSv from one exam • Many children have repeat testing - Among children with ≥1 CT, the % with >1 CT in a year increased from 20% in 1998 to 42% in 2006-2008 Many exams resulted in more than a doubling of risk of dying from leukemia 5 years after exam • 1 in 5 children <1 year • 1 in 10 children 1 year • 1 in 20 children 2-4 years Discussion and Conclusions Factors Contributing to Increased Advanced Medical Imaging Use Improvements in technology Increased capacity Patient demand – no perceived disincentive Physician demand • Easy • Lack of tolerance for ambiguity • Limited evidence-based guidelines (or any guidelines) Malpractice concerns – leads to defensive imaging High profitability – self-referral How to Reduce Radiation Exposure Reduce the number of studies: shared responsibility • Make sure test hasn’t already been done • Need evidence-based guidelines Reduce doses per test: • Standard protocols • Dose reference levels Educate physicians and technologists on importance of reducing dose Educate patients and providers about risks & benefits of imaging Directly assess the risks /benefits of CT to inform practice Conclusions Medical Imaging is an integral component of medical care However, there are few evidenced based guidelines about when to image, and the default is to over-image More widespread efforts needed to reduce dose, especially in children, by • Reducing unnecessary exams • Reducing dose when imaging necessary Research is desperately needed to determine when to image, and how to do so using lowest possible doses