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Infection Prevention in the Perioperative Setting HIPAN Conference November 7, 2015 Anne K. Massie, RN, MSN, CIC Infection Prevention Coordinator Castle Medical Center Kailua, HI Today’s Objectives: • Describe the role of microorganisms in disease. • Describe how microorganisms are transmitted in healthcare settings. • Define standard and transmission-based precautions in healthcare settings. • Describe surgical site infections (SSIs). • Identify evidence-based SSI prevention measures. • Apply today’s knowledge to a patient case study. What Is Infection Prevention? 1. More than control measures 2. Best outcomes for our patients - it is less expensive financially, emotionally, and physically not to acquire an infection 3. Everyone has a role - hand hygiene, isolation practices, clean environment and equipment, best practices for clinical and non-clinical associates 4. Evidence-based guidelines 5. Regulatory compliance s - TJC, CMS, AH, etc. Why Prevent Transmission? • • • • Saves lives Prevents pain, suffering , loss of function, and death Prevents outbreaks Saves money - for patients, healthcare facilities, and taxpayers • Increases patient satisfaction • It is the caring way Key Terms • Infection: The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body. – An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent. • Infectious Disease: Illness (infection) caused by microorganisms. Identified public health diseases require reporting to local and/or federal authorities. – Measles, Chlamydia, Influenza, VRSA Key Terms • Colonization – Microorganism proliferation on host body sites without eliciting an immune response, cellular damage, or clinical expression of infection • Symbiosis – Two dissimilar organisms living together to the mutual beneficial association of each other. – Many bacteria live on and in humans performing necessary functions for survival of both species: Bacteroides, Staphylococcus, E. coli Key Terms • Community Acquired Infection – An infection that is present or incubating at the time of admission to a healthcare facility (e.g., acute care hospital, skilled nursing facility) • Healthcare Acquired Infection (HAI) – An infection that develops in a patient who is cared for in any setting where healthcare is delivered and was not present or incubating at the time of the care (POA) – CMS requires public reporting of certain HAIs as part of pay for performance: Colon SSIs, Hysterectomy SSIs, CAUTI, CLABSI, Clostridium difficile, MRSA bacteremias Micro 101: Bacteria, Fungi, Protists • Prokaryotes – Bacteria: – Single cell, no true nucleus or organelles (prokaryotes) – Staphylococcus aureus, Clostridium perfringens, Mycobacterium tuberculosis, Neisseria meningitidis • Eukaryotes - Fungi & Protists: – Single & multi celled organisms with a true nucleus and organelles; – Fungi - Yeast, filamentous molds – Protists - Algae, protozoans, and slime molds Streptococci & Filamentous Mold Viruses • Viruses: acellular, protein-based, intracellular parasites – Influenza, Meningitis (viral), Pertussis, Rubella Did You? Prions • Prions: acellular protein capable of folding in unique ways • Cause spongiform encephalopathies (CJD, aka “Mad Cow”) Chain of Infection Germ Relationships How Do YOU Break the Chain? What Does Evidence-Based Practice Say? Hand Hygiene • Oldest evidence-based practice (1847) • National average = 48% • Decreases HAIs dramatically when compliance is high • Healthcare workers perceive their compliance is higher than what is observed (video, electronic systems, secret shopper) • Alcohol-based rubs take less time, act faster, kill viruses, and are less irritating • Soap and water removes visible soil and bacteria • THE SINGLE MOST EFFECTIVE INFECTION PREVENTION MODALITY WHO 5 Moments of Hand Hygiene Missed Opportunity Who Is Protected? Protects The Patient Protects the HCW Standard Precautions • A group of infection prevention practices that apply to all patients, regardless of suspected or confirmed diagnosis or presumed infection status. • Determined by the extent of anticipated blood, body fluid or pathogen exposure. • Standard Precautions is a combination and expansion of Universal Precautions and Body Substance Isolation. • WEAR WHAT YOU NEED TO PROTECT YOURSELF AND YOUR PATIENTS. What are Standard Precautions? • Hand Hygiene • Personal Protective Equipment (PPE): – Gloves, gown, goggles • Appropriate disposal of sharps • Respiratory Etiquette • Safe injection practices: – One needle, one syringe, one time only (The One & Only Campaign) • Clean up biohazardous spills wearing PPE • Textiles and laundry – Store and transport appropriately • Clean shared patient equipment – Sani Wipes, High Level Disinfection or Sterile Processing – Single Use Items – Do NOT Reuse (Label) Transmission-Based Precautions • Used when Standard Precautions alone do not completely interrupt transmission of infectious agents • Three types: – Airborne – Contact – Droplet • Use in addition to Standard Precautions • Some diseases have multiple routes of transmission requiring more than one precaution type, e.g., MERS, Measles, Varicella, SARS, Ebola • Use: Patients with suspect or confirmed infections Airborne Transmission • Dissemination of either airborne droplet nuclei or small particles from the respiratory tract containing infectious agents that remain suspended in the air for long periods of time • PPE: N95 Respirator • Requires negative pressure room • Diseases: TB, Measles, Chicken Pox, Shingles (disseminated), Ebola Contact Transmission • Most important and frequent mode of transmission of HAIs • Direct: Body surface to body surface • Indirect: Susceptible host touches contaminated surface • PPE: Gown and gloves • Use for MDROs, infectious diarrhea, Ebola, conjunctivitis, draining wounds, bed bugs Droplet Transmission Droplet Transmission PPE: Surgical Mask, Eye Protection within 6 feet • Droplets generated from the infected person are propelled a short distance through the air and deposited on the host’s conjunctivae, nasal mucosa, and mouth • A form of contact transmission • Influenza, Neisseria meningitidis (Bacterial Meningitis), Pertussis Defining SSIs Perioperative Setting • The area utilized immediately before, during and after the performance of a clinical intervention or clinically invasive procedure – Complex healthcare area: procedures, instruments, technologies – Regulatory scrutiny: CDC, FDA, EPA, CMS, TJC • Summary: Unique and challenging environment • Goal: Ensure the highest standard of care to each patient during their journey within the perioperative arena • Infection Prevention Goal: Prevent surgical site infections and disease transmission Surgical Site Infections (SSIs) • SSI – Infection following an operative procedure that was performed in an inpatient or outpatient setting where: – Procedure performed in an operative setting per FGI/AIA criteria when constructed or renovated – Procedure or reoperation (via an incision that was left open) involved at least one incision • Now account for 31% of all HAIs • Most prevalent HAIs today replaced CAUTIs as #1 • Associated with prolonged hospitalization, increased morbidity and mortality, and loss of function • Mortality rate = 3% Surgical Site Infections (SSIs) • Patients with an SSI: – 3-5x higher readmission risk and rates than non-SSI patients – More likely to be admitted / transferred to the ICU – More likely to die if SSI is due to MRSA • Average cost of an SSI > $20,000 • Average cost of an orthopedic SSI > $90,000 • SSIs are devastating to the patient, the perioperative team, and the hospital SSIs – Superficial • Superficial Incisional – Occurs within 30 days of procedure – Involves only the skin and subcutaneous tissue – Primary or secondary incision (CABG graft site) – Purulent drainage, pain, tenderness, swelling, erythema, heat – Positive culture collected aseptically – May exhibit spontaneous dehiscence or be deliberately reopened by physician SSIs – Deep Incisional* • Deep Incisional – Occurs within 30 or 90 days (depending on NHSN procedure type) – Involves deep soft tissues: fascial and muscle layers – Purulent drainage, fever, pain, tenderness – Abscess – Positive culture collected aseptically – May exhibit spontaneous dehiscence or be deliberately reopened by physician SSIs – Deep Incisional • Organ Space – Occurs within 30 or 90 days (depending on NHSN procedure type) – Involves any part of the body deeper than the fascial and muscle layers that was opened or manipulated during the surgical procedure – Purulent drainage – Closed drainage, T-tube, CT guided drain – Abscess – Positive culture collected aseptically Oh my gosh! SSI Prevention Infection Prevention Management • Evidence-based guidelines: – SHEA / IDSA 2014 Update (Anderson et al.) – 7S Bundle (Spencer) – NHSN SSI Definition (CDC) • Apply appropriate precautions for suspect or confirmed infection status: Standard + Transmission-Based • Communicate plan to the entire healthcare team • Process Improvement Teams • Report suspected infections to Infection Preventionist • Report breaches in infection prevention practices per hospital policy/protocol Patient SSI Risk Factors • Patient Risk Factors – Glycemic control (Diabetes) – Smoking status – Steroid Use, other medications – Obesity – Preoperative albumin level (malnutrition) – MRSA and MSSA colonization – Renal function – Prolonged hospitalization prior to surgical procedure – Medical and surgical history Pre OP Nursing Assessment • Physical assessment: rash with fever and/or cough, cough – wet or paroxysmal, chronic wound infection, abscess • Patient history: Recent surgical procedure, wound healing, diarrhea with recent antibiotic use or hospitalization, cough with weight loss, paroxysmal cough, physician notes, SNF resident, HD • Lab & Imaging: Abnormal chest x-ray, culture results, HbA1C, albumin level, renal function • Antimicrobials – Which one and Why? • Travel History: Foreign vs. domestic • Patient knowledge Patient Decolonization • Staphylococcus aureus carriers have a 3-6x higher risk of SSI than non-carriers (colonized) • Management: 1. Screen for Staphylococcus aureus colonization (MSSA and MRSA) 2. Intranasal treatment with mupirocin 3. Chlorhexadine gluconate (CHG) bathing • 2% CHG wipes persist for 12 hours while 4% solution does not Shared Patient Equipment • Clean, disinfect, and/or sterilize per manufacturer’s instructions (IFUs) • Use correct products for the equipment • Use correct reprocessing methods • Reduce “flashing” (IUSS) – Purchase additional instrumentation – OR Scheduling Pre OP Prep & • Clipping preferred method for hair removal when indicated • Surgical site prep: Follow (IFUs) during application – Allow to completely air dry; no “fanning” • Surgical hand scrub – First scrub of the day – Avagard® for subsequent scrubs Antimicrobial Prophylaxis • Antimicrobial prophylaxis: Recommended antimicrobial for procedure type and known allergies – Administer within 1 hour of incision cut time – Two (2) hours for fluoroquinolones and vancomycin – Fluoroquinolone use linked to C. diff infections • “Scrub the Hub” for 15 seconds or use CHG impregnated hub cover • Hand hygiene, don clean gloves • Disinfect med vial rubber septum prior to accessing Perioperative Environment • OR Room Ventilation – Positive to the outside hallway or clean/sterile core • OR Temperature and humidity – Temperature range: 62 - 75⁰ F – Humidity: 20 to 60% • Minimize OR traffic • Between case cleaning • Daily Terminal OR cleaning Quality Improvement Processes • PDCA (Plan, Do, Check/Study, Act) – RCI (Rapid Cycle Improvement) – 90 day process • • • • SSI Drilldown Team with each SSI or cluster Periop Rep attends Infection Control Meetings Hand hygiene and PPE audits and feedback Physician notification of SSIs -> results in improved SSI risk reduction • Surgical Technique - physician dependent – Peer Review process when a high SSI rate is attributed to an individual surgeon • Collaboratives and Bundles: Premiere, Quest, SUSP Application CASE STUDY • Teams will work together (Just like at work!) • Review case scenario to develop a plan addressing these questions: • What risk factors are present? • What disease(s) are of concern in this case? • What interventions should be done? • How does this differ from your current practice? What YOU Learned Today Today’s Objectives: • Describe the role of microorganisms in disease. • Describe how microorganisms are transmitted in healthcare settings. • Define standard and transmission-based precautions in healthcare settings. • Describe surgical site infections (SSIs). • Identify evidence-based SSI prevention measures. • Apply today’s knowledge to a patient case study. Microbiology and Precautions • Microorganisms can colonize or infect humans • Hand hygiene is the single most effective method to prevent infection transmission in healthcare settings • Standard Precautions are used for every patient • Transmission-Based Precautions are used for patients with suspect or confirmed infections – Includes Airborne, Droplet and Contact Precautions – Some diseases require multiple types of precautions SSIs: Definition and Risks • SSIs are costly to both patients and healthcare facilities • There are 3 types of SSIs per the CDC: – Superficial Incisional – Deep Incisional – Organ Space • Patients present with a variety of SSI risk factors • Healthcare facilities have risk factors for SSIs – Temperature and humidity – OR ventilation – Cleaning, disinfecting, and sterilizing equipment SSI Prevention • SSI Prevention includes (not limited to): – Using evidence-based guidelines: SHEA, 7S Bundle – Patient decolonization and CHG bathing – Hand hygiene and PPE – Antimicrobial Stewardship: Right drug, Timing – Surgical site prep – Scrub the Hub – Process Improvement Teams – Reporting infections to surgeons – Collaborative and Bundles SSI Prevention Goals • Goal: Ensure the highest standard of care to each patient during their journey within the perioperative arena • Infection Prevention Goal: Prevent surgical site infections and disease transmission Scrub Your Paws! References • • • • • • • • • • Anderson, D., et al. (2014). SHEA / IDSA Practice Recommendations: Strategies to Prevent Surgical Site Infections in Acute Care Hospitals – 2014 Update. Retrieved from http://www.jstor.org/stable/10.1086/676022 Bode, L., et al. (2010). Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. The New England Journal of Medicine, 362:9-17. Centers for Disease Control and Prevention. (2007). Guidelines for Isolation Precautions: Preventing Transmisison of Infectious Agents in Healthcare settings. Retrieved from http://www.cdc.gov/hicpac/2007IP/2007isolationPrecautions.html Centers for Disease Control and Prevention. (2011.) Healthcare associated infections (HAIs). Retrieved from http://www.cdc.gov/HAI/settings/outpatient/basic-infection-control-prevention-plan-2011/transmission-basedprecautions.html Centers for Disease Control and Prevention. (2006). Management of Multi-Drug Resistant Organisms in Healthcare Settings. Retrieved from http://www.cdc.gov/hicpac/pdf/MDRO/MDROGuideline2006.pdf Centers for Disease Control and Prevention. (2015). National Healthcare Safety Network: Surgical Site Infection (SSI) Event. Retrieved from http://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf Darouiche, R., et al. (2010). Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. The New England Journal of Medicine, 362:18-26. Gibbs, J., et al. (1999). Preoperative serum albumin level as a predictor of operative mortality and morbidity. Archives of Surgery, 134(1). Gokce, N., et al. (2002). Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function. Circulation, 105, 1567-1572. References • • • • • • • • • Infectious Disease Society of America. (n.d.). What is an infectious disease specialist? Retrieved from http://www.idsociety.org/ID_Specialist Khuri, S. F., et al. (1995) The National Veterans Administration Surgical Risk Study: risk adjustment for the comparative assessment of the quality of surgical care. Journal of the American College of Surgeons, 180(5), 519531. Magill, S.S., et al. (2012). "Prevalence of healthcare-associated infections in acute care hospitals in Jacksonville, Florida". Infection Control Hospital Epidemiology, 33(3): 283-91. Pittet, D. (2001). Improving adherence to hand hygiene practice: a multidisciplinary approach. Emerging Infectious Diseases. 7(2), 234-240. Plodkowski, R. A. (2001). Pre-surgical evaluation of diabetic patients. Clinical Diabetes, 19(2), 92-95. Spencer, M. (2013). The 7S Bundle. Retrieved from http://eo2.commpartners.com/users/apic/downloads/130828_PPT_Final_[Compatibility_Mode].pdf St. Jacques, P., Minear, M. (n.d.) Improving perioperative patient safety through the use of information technology. Retrieved from http://www.ahrq.gov/sites/default/files/wysiwyg/professionals/quality-patient-safety/patient-safetyresources/resources/advances-in-patient-safety-2/vol4/Advances-StJacques_105.pdf Sweeney, W. B. (2009). Preoperative evaluation and risk management. Clinics In Colon and Rectal Surgery, 22(1), 5-13. Ryder, M. (n.d.) Improving Skin Antisepsis: 2% No-Rinse CHG Cloths Improve Antiseptic Persistence on Patient Skin Over 4% CHG Rinse-Off Solution. Retrieved from http://www.hqinstitute.org/sites/main/files/fileattachments/ryder_poster_0.pdf References • • • Waisbren, E., et al. (2010). Percent body fat and prediction of surgical site infection. Journal of the American College of Surgeons, 210(4), 381-389. World Health Organization. WHO 5 Moments of Hand Hygiene. Retrieved from http://www.who.int/apsc/tools/Five_Moments Xu, J., et al. (2007). Evolution of Symbiotic Bacteria in the Distal Human Intestine. PLOS Biology, 5(7). elements