Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Measuring Evolution of Populations AP Biology 2010-2011 5 Agents of evolutionary change Mutation Gene Flow Non-random mating Chemical Changes to DNA Migration Sexual Selection AP Biology Genetic Drift Selection Small population Natural Selection Differential Survival Hardy-Weinberg equilibrium Hypothetical situation serves as null hypothesis non-evolving population REMOVE all agents of evolutionary change 1. no genetic drift (very large population size ) 2. no gene flow (no migration in or out) 3. no mutation (no chemical change to DNA) 4. random mating (no sexual selection) 5. no natural selection (equal survival) AP Biology The Hardy-Weinberg Formula The Hardy-Weinberg formula can be used to determine if a population is in genetic equilibrium p2(AA) + 2pq (Aa) +q2(aa) = 1.0 The frequency of the dominant allele (A) plus the recessive allele (a) equals 1.0 p + q = 1.0 AP Biology A Population in Equilibrium AP Biology If 98 out of 200 individuals in a population express the recessive phenotype, what percent of the population would you predict would be heterozygotes? Q2 = 98/200 = .49 q = square root .49 = .7 p = .3 (p + q = 1 so p + .7 = 1) 2pq = 2 x .7 x .3 = .42 = 42% AP Biology Directional Selection Directional selection Changing environmental conditions can shift allele frequencies in a consistent direction Forms of traits at one end of a range of phenotypic variation become more common AP Biology Predation and Rock-Pocket Mice In rock-pocket mice, two alleles of a single gene control coat color Night-flying owls are the selective pressure that directionally shifts the allele frequency AP Biology Stabilizing Selection: Body Weight of Sociable Weavers Stabilizing selection Natural selection that favors an intermediate phenotype and eliminates extreme forms AP Biology Disruptive Selection Disruptive selection Natural selection that favors extreme forms of a trait and eliminates the intermediate forms AP Biology Example of strong selection pressure Tay Sachs primarily in Ashkenazi Jews & Cajuns recessive disease = aa lysosomal storage disease lack of one functional digestive enzyme in lysosome build up undigested fat in brain cells children die before they are 5 years old So where do new cases of come from? APTay-Sachs Biology Sexual Selection Sexual selection acts on an organism's ability to obtain or successfully copulate with a mate Sexual selection is often powerful enough to produce features that are harmful to the individual's survival. Peacock Video - 11 minutes AP Biology Example of heterozygote advantage Sickle cell anemia inherit a mutation in gene coding for one of the subunits in hemoglobin oxygen-carrying blood protein normal allele = Hb mutant allele = Hs recessive trait = HsHs low oxygen levels causes RBC to sickle clogging small blood vessels damage to organs AP Biology often lethal Sickle cell frequency High frequency of heterozygotes 1 in 5 in Central Africans = HbHs unusual for allele with severe detrimental effects in homozygotes 1 in 100 = HsHs usually die before reproductive age Why is the Hs allele maintained at such high levels in African populations? Suggests some selective advantage of bHs being heterozygous… H AP Biology Single-celled eukaryote parasite (Plasmodium) spends part of its life cycle in red blood cells Malaria 1 liver 2 AP Biology 3 Heterozygote Advantage In tropical Africa, where malaria is common: homozygous dominant (normal) reduced survival or reproduction from malaria: HbHb homozygous recessive reduced survival & reproduction from sickle cell anemia: HsHs heterozygote carriers survival & reproductive advantage: HbHs Hypothesis: In malaria-infected cells, the O2 level is lowered enough to cause sickling which kills the cell & destroys the parasite. AP Biology Frequency of sickle cell allele & distribution of malaria