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Membranes: • Epithelial tissue + Connective tissue • Mucus membranes • Serous membranes • Cutaneous membranes • Synovial membranes Mucous Membranes Mucous membranes (mucosae) • Line organs with connections to the outside environment (mouth, intestines, nasal passages, etc.) • Usually composed of either stratified squamous or simple columnar epithelium covering a layer of loose connective tissue • Submucosa : connective tissue layer that connects the mucosa to underlying structures Mucous Membranes Mucous membranes (mucosae) • May contain goblet cells or multicellular glands – Can produce large quantities of mucus – Mucus consists primarily of water, electrolytes, and the protein mucin • Some mucosae also can absorb (e.g., the epithelial layer in the intestine) Serous Membranes Serous membranes (serosae) • Line walls and cover organs of body cavities (e.g., thorax and abdominopelvic cavities) • Consist of a continuous sheet doubled over on itself to form two layers • Pericardium • Pleura • Peritoneum • The portion of the membrane that covers the outer surface of organs is called the visceral layer. • The portion of the membrane that lines the cavity wall is called the parietal layer. Serosal Fluid • “Serous fluid” – watery, thin, composed of water and enzymes • Creates moist, slippery surface, reduces friction between organs and cavity surfaces • Serous fluid is called transudate – Location of transudate • Thorax – pleural fluid • Abdomen – peritoneal fluid • Heart – pericardial fluid Some medical terms • Hemothorax – Injury to thoracic cavity, such as broken rib, the blood and other cells leak from ruptured capillaries into the pleural space and create a hemothorax • Effusion – excessive fluid – Abdominal Cavity – called ascites – Thoracic Cavity – called pleural effusion – Heart – pericardial effusion – Causes –congestive heart failure, peritonitis • Transudate: A fluid that passes through a membrane, which filters out all the cells and much of the protein, yielding a watery solution. • A transudate is a filtrate of blood. It is due to increased pressure in the veins and capillaries that forces fluid through the vessel walls or to a low level of protein in blood serum. • Transudate accumulates in tissues outside the blood vessels and causes edema (swelling). Cutaneous Membrane • Also called integument (or, more simply, skin) • Composed of an outer keratinized stratified squamous epithelium, or epidermis • Epidermis is attached to an underlying layer of dense irregular connective tissue called the dermis. • Dermis contains collagenous, reticular, and elastic fibers which enable skin to be both strong and elastic Diagnosing by mucous membrane clues: • Are they Dry or Moist? Dehydration = dry, “tacky” • Capillary Refill Time- the time it takes for blood to return to the capillaries >2 sec – low blood pressure, compromised cardiac output < 1 sec – high blood pressure, hypercompensated state Synovial Membranes • Line the cavities of joints • Composed of loose connective tissue and adipose tissue covered by a layer of collagen fibers and fibroblasts • Manufacture the synovial fluid that fills the joint spaces • No epithelial cells! • What Color? Yellow = elevated bilirubin icterus (condition), juandice (appearance) can be caused by liver failure, hemolytic anemia Blue = lack of oxygen, tissues are not receiving adequate oxygen (obstruction, pneumonia - airways) called hypoxia Bright Red = increased blood flow (allergic reaction, fever), the term for this is hyperfused hyperemia White/ Pale = anemia, shock, hypothermia Muscle Tissue • Composed of specialized proteins actin and myosin fibers • Three types of muscle tissue – Skeletal – Smooth – Cardiac Skeletal Muscle • Large cells (foot long or more!)that contain hundreds of nuclei and mitochondria • Usually controlled through conscious efforts (voluntary muscle) • Skeletal muscle cells are striated. • Skeletal muscle cells are bundles of fibers held together by loose connective tissue. • Voluntary Striated Muscle Smooth Muscle • Composed of small, spindle-shaped cells that lack striations • Smaller cells than skeletal muscle • Muscle contractions cannot be consciously controlled (nonstriated involuntary muscle) • Found in the walls of hollow organs, in exocrine glands, and along the respiratory tract – Responsible for peristalsis in gastrointestinal tract, constriction of blood vessels, and emptying of urinary bladder Cardiac Muscle • Found only in the heart • Also smaller cells • Entirely involuntary and striated • Cardiac muscle cells connected to one another via intercalated disks (intercellular junction) Nervous Tissue • Found in the brain, spinal cord, and peripheral nerves • Composed of two general cell types: – Neurons – Supporting neuroglial cells Nervous Tissue Neurons • Longest cells in the body; three primary parts: – Perikaryon – the cell body; contains the nucleus – Dendrites – short cytoplasmic extensions; receives impulses – Axons – long, single extension; conducts impulses away from the cell body Neuroglial cells – Support the neurons