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Record #1 of 101 ID: CN-00708525 AU: Sharquie KE AU: Al-Rawi JR AU: Al-Nuaimy AA AU: Radhy SH TI: Bacille Calmette-Guerin immunotherapy of viral warts SO: Saudi Medical Journal YR: 2008 VL: 29 NO: 4 PG: 589-93 XR: EMBASE 2008507751 PT: Journal: Article DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/525/CN00708525/frame.html KY: Absence of Side Effects; Si [Side Effect]; Adolescent; Adult; Article; Bcg Vaccination; Clinical Trial; Controlled Clinical Trial; Controlled Study; Drug Efficacy; Drug Response; Drug Safety; Female; Follow up; Human; Immunotherapy; Iraq; Major Clinical Study; Male; Preschool Child; Randomized Controlled Trial; Single Blind Procedure; Teaching Hospital; Verruca Plantaris; Dt [Drug Therapy]; *Verruca Vulgaris; Dt [Drug Therapy]; *Bcg Vaccine; Ae [Adverse Drug Reaction]; *Bcg Vaccine; Ct [Clinical Trial]; *Bcg Vaccine; Dt [Drug Therapy]; *Bcg Vaccine; Dl [Intradermal Drug Administration]; Placebo AB: Objective: To assess the effectiveness of the Bacille Calmette-Guerin (BCG) vaccine in the treatment of viral warts. Methods: A single blind placebo controlled study conducted at the Department or Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq from March 2005 to June 2006, Two hundred patients with vital warts were enrolled in this study, and were fully assessed before therapy. The patients were divided into 2 equal matched groups. Group 1 was designed as the treatment group and received BCG vaccine in 1-3 doses with a one-month interval, while group 2 was injected with distilled water. The patients were evaluated every 2 weeks for evidence of regression of lesions. The follow up period lasted for 3 months after the last dose. Results: A total of 154 patients completed the study: 81 patients in group I and 73 patients in group II. Thirty (39.7%) patients out of 81 patients in group I showed complete recovery. These results were significantly high (p<0.05) when compared with total response, 10 (13.7%) out of 73 patients in group II. No recurrence has been reported during the follow up period. When cases that failed to respond to placebo were treated with BCG in a similar manner to group I, there was total response in 15 (42.7%) out of 44 patients. No side effects were observed. Conclusions: The BCG vaccine was an effective and safe modality of treatment of viral warts. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #2 of 101 ID: CN-00686818 AU: Banihashemi M AU: Pezeshkpoor F AU: Yazdanpanah MJ AU: Family S TI: Efficacy of 80% phenol solution in comparison with cryotherapy in the treatment of common warts of hands. SO: Singapore medical journal YR: 2008 VL: 49 NO: 12 PG: 1035-7 PM: PUBMED 19122958 PT: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AD: Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/818/CN00686818/frame.html KY: Administration, Topical; Adolescent; Caustics [administration & dosage]; Cryotherapy; Phenol [administration & dosage]; Single-Blind Method; Warts [therapy]; Female; Humans; Male CC: SR-SYMPT AB: INTRODUCTION: The common wart is a common infectious disease caused by human papilloma virus. A variety of therapeutic modalities are available. Cryotherapy (liquid nitrogen) is one of the most common treatment forms. It freezes the tissue and destroys warts. Phenol is a caustic agent. Our purpose was to evaluate and compare the efficacy of cryotherapy and 80 percent phenol solution on common warts of hands. METHODS: This single-blinded clinical trial study was performed on 60 patients with common warts referred to the dermatology clinic of Ghaem Hospital Mashhad, Iran, in 2002. Patients were randomly divided into two groups; 30 patients were treated with cryotherapy and 30 patients were treated with 80 percent phenol, on a once-weekly basis until complete clearance of the lesions or a maximum duration of six weeks. RESULTS: Complete clearance of warts after six weeks was observed in 70 percent of patients who were treated with cryotherapy, and 82.6 percent of patients in the 80 percent phenol group; there was no statistically significant difference between the two methods (p-value is 0.014). CONCLUSION: Our data indicates that 80 percent phenol and cryotherapy are effective and simple treatments for common warts of hands, and patients do not experience any pain during the treatment. Record #3 of 101 ID: CN-00648460 AU: Canpolat F AU: Cemil BC AU: Eskioğlu F TI: Liquid nitrogen cryothearpy of plantar verrucae: cryoblast is more effective than the cryo-spray. SO: European journal of dermatology : EJD YR: 2008 VL: 18 NO: 3 PG: 341-2 PM: PUBMED 18474468 PT: Letter; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/460/CN00648460/frame.html KY: Adolescent; Cryotherapy [methods]; Double-Blind Method; Foot Dermatoses [therapy]; Nitrogen [administration & dosage]; Treatment Outcome; Warts [therapy]; Adult; Child; Female; Humans; Male; Middle Aged Record #4 of 101 ID: CN-00631067 AU: Rahimi AR AU: Emad M AU: Rezaian GR TI: Smoke from leaves of Populus euphratica Olivier vs. conventional cryotherapy for the treatment of cutaneous warts: a pilot, randomized, single-blind, prospective study. SO: International journal of dermatology YR: 2008 VL: 47 NO: 4 PG: 393-7 PM: PUBMED 18377608 PT: Comparative Study; Journal Article; Randomized Controlled Trial AD: Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/067/CN00631067/frame.html KY: Adolescent; Cryotherapy; Foot Dermatoses [therapy]; Hand Dermatoses [therapy]; Phytotherapy [methods]; Pilot Projects; Plant Leaves; Plant Preparations [therapeutic use]; Populus; Prospective Studies; Single-Blind Method; Skin [pathology]; Smoke; Treatment Outcome; Warts [therapy]; Adult; Child; Child, Preschool; Female; Humans; Male CC: SR-COMPMED AB: BACKGROUND: Populous euphratica tree which belongs to Salicaceae family is naturally distributed in many parts of the world. Our purpose was to compare the therapeutic effects of smoke of its burnt leaves with conventional cryotherapy in patients with warts. METHODS: Sixty consecutive wart patients were randomly treated with leaves of Populous euphratica tree (Group A) or conventional cryotherapy (Group B) and were followed up for 22 weeks. RESULTS: The respective end results in group A and group B were; Complete cure rates 66.7% vs. 46.4% (P= NS), partial resolution rates 8.3% vs. 14.3% (P= NS). The recurrence rate however, was 4.2% in group A and 32.2% in group B patients (P= 0.024). CONCLUSION: The smoke of burnt leaves of Populus euphratica tree can be equally effective for treatment of hand and foot warts as cryotherapy. Record #5 of 101 ID: CN-00629967 AU: Yazdanfar A AU: Farshchian M AU: Fereydoonnejad M AU: Farshchian M TI: Treatment of common warts with an intralesional mixture of 5-fluorouracil, lidocaine, and epinephrine: a prospective placebo-controlled, double-blind randomized trial. SO: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] YR: 2008 VL: 34 NO: 5 PG: 656-9 PM: PUBMED 18261100 PT: Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Sina Hospital, Hamedan, Iran. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/967/CN00629967/frame.html KY: Adolescent; Antimetabolites [administration & dosage]; Double-Blind Method; Drug Therapy, Combination; Epinephrine [administration & dosage]; Fluorouracil [administration & dosage]; Injections, Intralesional; Lidocaine [administration & dosage]; Prospective Studies; Treatment Outcome; Warts [drug therapy]; Adult; Female; Humans; Male AB: BACKGROUND: 5-Fluorouracil is an antimetabolite that has been known to be effective for the treatment of common warts. OBJECTIVE: The objective was to evaluate the efficacy of a combination of 5-fluorouracil, lidocaine, and epinephrine (5-FU+LE) for the treatment of common warts. MATERIALS AND METHODS: Of the 40 patients initially enrolled, 34 patients with at least 68 verruca vulgaris (one pair for each subject) completed the study. The selected warts were randomized into two treatment groups, with one wart on each patient receiving intralesional 5-FU+LE (4 mL of 50 mg/mL 5-fluorouracil and 1 mL of a mixture of 20 mg/mL [2%] lidocaine and 0.0125 mg/mL epinephrine) and the other receiving intralesional normal saline placebo using a Mantoux needle. Patients received up to four injections at weekly intervals and were followed at 1 and 6 months after the initial injection. RESULTS: Complete response was observed in 64.7% of the warts treated with 5-FU+LE compared to 35.3% in the warts treated with placebo (p<.05). Systemic reaction or treatment-related adverse medical events and recurrence rate did not differ significantly between two groups. CONCLUSION: The results show that intralesional 5-FU+LE is a safe and effective approach for common warts with high success rate. Record #6 of 101 ID: CN-00616009 AU: Wenner R AU: Askari S AU: Cham P AU: Warshaw E TI: A double-blind, randomized controlled trial of duct tape for the treatment of common warts in an adult population Abstract P47. American Academy of Dermatology 65th Annual Meeting February 2-6, 2007 SO: Journal of the American Academy of Dermatology YR: 2007 VL: 56 NO: 2 PG: AB12 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/009/CN00616009/frame.html CC: SR-SKIN Record #7 of 101 ID: CN-00630719 AU: Adalatkhah H AU: Khalilollahi H AU: Amini N AU: Sadeghi-Bazargani H TI: Compared therapeutic efficacy between intralesional bleomycin and cryotherapy for common warts: a randomized clinical trial. SO: Dermatology online journal YR: 2007 VL: 13 NO: 3 PG: 4 PM: PUBMED 18328198 XR: EMBASE 2007366592 PT: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AD: Dermatology department, Bouali University Hospital, Ardabil University of Medical Sciences, Ardabil, Iran. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/719/CN00630719/frame.html KY: Adolescent; Antibiotics, Antineoplastic [administration & dosage]; Bleomycin [administration & dosage]; Cryotherapy [methods]; Follow-Up Studies; Hand; Injections, Intralesional; Leg; Treatment Outcome; Warts [pathology] [therapy]; Adult; Child; Female; Humans; Male AB: In spite of many available studies on bleomycin and cryotherapy in treating warts, little head to head research is done to compare efficacy of these treatments. Our aim was to compare the therapeutic effects of intralesional bleomycin and cryotherapy on common warts of the hands and feet. In this clinical trial 44 patients above 12 years of age referred to the dermatology clinic of Bouali University Hospital were enrolled. The patients were required to have warts on at least two symmetric limbs (hands or feet). The warts located on right and left limbs of each patient were examined and counted. Each patient received both cryotherapy and intralesional bleomycin on his or her warts. The two treatment types were randomly allocated to either right sided or left sided warts. Each patient was evaluated at 2 week intervals and retreated if necessary up to three times. Data were analyzed by SPSS 11 and EPI Info 2002 statistical packages. The mean number of warts was 5.2 on upper limbs and 4.6 on lower limbs. In 86.4 percent of the cases all warts on the limb side treated by intralesional bleomycin were cleared compared with 68.2 % for cryotherapy (P<0.05). Relative risk for the effect of bleomycin compared to cryotherapy in this regard was 1.27 (1<RR<1.6). We found bleomycin to have a clearance rate equal to 87.6 percent of warts, compared to 72.3 percent by cryotherapy. Relative risk for therapeutic effect of bleomycin compared to cryotherapy in this regard was 1.23 (1.11<RR<1.33). Conclusion: Intralesional bleomycin is more effective than cryotherapy in treating warts on hands and feet. Record #8 of 101 ID: CN-00579360 AU: Wenner R AU: Askari SK AU: Cham PM AU: Kedrowski DA AU: Liu A AU: Warshaw EM TI: Duct tape for the treatment of common warts in adults: a double-blind randomized controlled trial. SO: Archives of dermatology YR: 2007 VL: 143 NO: 3 PG: 309-13 PM: PUBMED 17372095 PT: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. AD: Department of Dermatology, University of Minnesota, Minneapolis, USA. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/360/CN00579360/frame.html KY: Double-Blind Method; Occlusive Dressings; Skin Diseases [therapy]; Warts [therapy]; Female; Humans; Male; Middle Aged CO: Comment in: Evid Based Nurs. 2007 Oct;10(4):108. PMID: 17905760. Comment in: J Fam Pract. 2007 Jul;56(7):531. PMID: 17612035. AB: OBJECTIVE: To evaluate the efficacy of duct tape occlusion therapy for the treatment of common warts in adults. DESIGN: Double-blind controlled clinical intervention trial. SETTING: Veterans Affairs medical center. PARTICIPANTS: A total of 90 immunocompetent adult volunteers with at least 1 wart measuring 2 to 15 mm were enrolled between October 1, 2004, and July 31, 2005. Eighty patients completed the study. INTERVENTION: Patients were randomized by a computergenerated code to receive pads consisting of either moleskin with transparent duct tape (treatment group) or moleskin alone (control group). Patients were instructed to wear the pads for 7 consecutive days and leave the pad off on the seventh evening. This process was repeated for 2 months or until the wart resolved, whichever occurred first. Follow-up visits occurred at 1 and 2 months. MAIN OUTCOME MEASURE: Complete resolution of the target wart. Secondary outcomes included change in size of the target wart and recurrence rates at 6 months for warts with complete resolution. RESULTS: There were no statistically significant differences in the proportions of patients with resolution of the target wart (8 [21%] of 39 patients in the treatment group vs 9 [22%] of 41 in the control group). Of patients with complete resolution, 6 (75%) in the treatment group and 3 (33%) in the control group had recurrence of the target wart by the sixth month. CONCLUSION: We found no statistically significant difference between duct tape and moleskin for the treatment of warts in an adult population. Record #9 of 101 ID: CN-00619889 AU: Viazis N AU: Vlachogiannakos J AU: Vasiliadis K AU: Theodoropoulos I AU: Saveriadis A AU: Karamanolis DG TI: Earlier eradication of intra-anal warts with argon plasma coagulator combined with imiquimod cream compared with argon plasma coagulator alone: a prospective, randomized trial. SO: Diseases of the colon and rectum YR: 2007 VL: 50 NO: 12 PG: 2173-9 PM: PUBMED 17914655 PT: Comparative Study; Journal Article; Randomized Controlled Trial AD: 2nd Department of Gastroenterology, Evangelismos Hospital, 59 Niriidon Street, 17561 P. Faliro, Athens, Greece. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/889/CN00619889/frame.html KY: Administration, Topical; Aminoquinolines [administration & dosage]; Antineoplastic Agents [administration & dosage]; Follow-Up Studies; Laser Coagulation [methods]; Lasers, Excimer [therapeutic use]; Ointments; Prospective Studies; Rectal Diseases [diagnosis] [therapy]; Time Factors; Treatment Outcome; Warts [diagnosis] [therapy]; Adult; Female; Humans; Male AB: PURPOSE: Despite the increasing incidence of condylomata acuminate, optimal treatment of anal warts is still undecided. This prospective, randomized study was designed to compare the efficacy of combined argon plasma coagulation and imiquimod cream vs. argon plasma coagulation alone in the management of intraanal warts. METHODS: From October 2002 to March 2005, 49 patients with intraanal warts were randomly assigned to argon plasma coagulation plus imiquimod cream (n = 24) vs. argon plasma coagulation alone (n = 25). Therapeutic sessions were repeated until the elimination of the warts. Efficacy of therapy was defined as the time needed for eradication. All patients were followed up for a mean period of 12 months for signs of recurrence. RESULTS: Elimination of warts was achieved earlier in patients receiving combination therapy compared with those receiving monotherapy with argon plasma coagulation (62.5 +/- 5.4 days vs. 91.2 +/- 6.4 days; P = 0.0016). A subgroup analysis performed in HIV-positive patients showed similar results (combination therapy 95 +/- 22.6 days; monotherapy 124.3 +/- 20.7 days; P = 0.033); however, in HIV-positive patients warts were eradicated later compared with HIV-negative patients (110.8 +/- 25.7 days vs. 65 +/- 25.4 days; P < 0.0001). No major complications were observed in our study population. After the follow-up period, recurrence of warts was evident in 22.7 percent of patients in the combination group compared with 34.7 percent of patients in the monotherapy group (P = 0.51). Recurrence was significantly higher in HIV-positive patients compared with HIV-negative patients (P = 0.0039). CONCLUSIONS: Combination therapy with argon plasma coagulator plus imiquimod cream results in earlier clearance of intra-anal warts in both immunocompetent and immunocompromised patients; however, it does not affect the rate of recurrence. Record #10 of 101 ID: CN-00586718 AU: Ebrahimi S AU: Dabiri N AU: Jamshidnejad E AU: Sarkari B TI: Efficacy of 10% silver nitrate solution in the treatment of common warts: a placebo-controlled, randomized, clinical trial. SO: International journal of dermatology YR: 2007 VL: 46 NO: 2 PG: 215-7 PM: PUBMED 17269982 PT: Journal Article; Randomized Controlled Trial AD: Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/718/CN00586718/frame.html KY: Adolescent; Silver Nitrate [therapeutic use]; Warts [drug therapy]; Adult; Child; Child, Preschool; Female; Humans; Male; Middle Aged AB: BACKGROUND: Warts are a common skin lesion, especially in children and young adults, caused by human papillomaviruses. So far, there is no definitive therapy for warts and the treatment is modified regularly to obtain the best result with the least discomfort to the patient. The aim of this placebo-controlled clinical trial was to evaluate the clinical efficacy, tolerability, and safety of 10% silver nitrate solution for the treatment of common warts. METHODS: Sixty individuals attending pediatrics and dermatology clinics and health centers in Yasuj, south-west of Iran, were recruited. The patients were divided into two groups: 30 patients received 10% silver nitrate solution (case group) and 30 control patients received black ink (placebo group). Silver nitrate solution was used every other day for 3 weeks. After 3 weeks, the patients were evaluated for healing, and treatment was continued for another 3 weeks if the lesions were still present. RESULTS: Complete regression of lesions was achieved in 19 of the 30 (63.33%) case patients. No significant side-effect was noted in the treated patients apart from temporary brownish discoloration of the skin which resolved 1 week after treatment. CONCLUSION: This study demonstrated that 10% silver nitrate solution can be used effectively for the treatment of warts with no serious complications. Record #11 of 101 ID: CN-00641064 AU: Vali A AU: Ferdowsi F TI: Evaluation of the efficacy of 50% citric acid solution in plane wart treatment. SO: Indian Journal of Dermatology YR: 2007 VL: 52 NO: 2 PG: 96-8 XR: EMBASE 2007340025 PT: Journal: Article DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/064/CN00641064/frame.html KY: Adolescent; Adult; Application Site Dermatitis; Si [Side Effect]; Article; Case Control Study; Chi Square Test; Child; Clinical Trial; Confidence Interval; Controlled Clinical Trial; Controlled Study; Double Blind Procedure; Drug Cost; Drug Efficacy; Drug Safety; Erythema; Si [Side Effect]; Female; Human; Informed Consent; Injection Site Dermatitis; Si [Side Effect]; Irritant Dermatitis; Si [Side Effect]; Lotion; Major Clinical Study; Male; Pain; Si [Side Effect]; Randomized Controlled Trial; Skin Burning Sensation; Si [Side Effect]; Skin Pruritus; Si [Side Effect]; Stinging Sensation; Si [Side Effect]; Treatment Outcome; *Verruca Vulgaris; Dt [Drug Therapy]; *Citric Acid; Ae [Adverse Drug Reaction]; *Citric Acid; Ct [Clinical Trial]; *Citric Acid; Cm [Drug Comparison]; *Citric Acid; Dt [Drug Therapy]; *Citric Acid; Pe [Pharmacoeconomics]; *Citric Acid; Tp [Topical Drug Administration]; Retinoic Acid; Ae [Adverse Drug Reaction]; Retinoic Acid; Cm [Drug Comparison]; Retinoic Acid; Dt [Drug Therapy]; Retinoic Acid; Tp [Topical Drug Administration] CC: SR-COMPMED AB: Background and Aims: Treatment of plane warts is problematic, methods such as cryotherapy and cauterization is associated with high recurrence rate, risk of scar, pain and high cost. Topical tretinoin causes irritant contact dermatitis that limited its use. Citric acid was used in treatment of warts in traditional medicine of Iran. We evaluated the efficacy of 50% citric acid solution in water in treatment of plane warts and compared it with 0.05% tretinoin lotion. Materials and Methods: This study was a double blind; prospective, case-control study.Seventy-five patients with bilateral plane warts who signed informed consent were included. Exclusion criteria were pregnancy, breast-feeding, suffering from any systemic disease and the use of any other drug due to treatment of warts in past six weeks. The patients randomly used citric acid or Tretinoin lotion to lesions at each side of the body. Randomization was performed by coin-flipping. Patients were examined at three weeks interval for six weeks and number of warts were recorded in the proforma, which included the name, sex, address and code of the drug that was used in each side of the body and side effects. The results were analyzed by Chi-square test statistically. Results: After six weeks 64.4% of the lesions in citric acid treated group disappeared versus 53.7% of the lesions in tretinoin treated group. This difference was significant (P value <o.o5, CI=95%). 45.5% of patients were at second decade (11-20 years). Incidence of irritant contact dermatitis with application of tretinoin was 22% versus 14.7% with citric acid. Conclusion: On the basis of this study, the treatment of plane warts by 50% citric acid is strongly suggested. This modality is superior to tretinoin lotion due to higher efficacy and low incidence of side-effects and lower cost. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #12 of 101 ID: CN-00573484 AU: de Haen M AU: Spigt MG AU: van Uden CJ AU: van Neer P AU: Feron FJ AU: Knottnerus A TI: Efficacy of duct tape vs placebo in the treatment of verruca vulgaris (warts) in primary school children. SO: Archives of pediatrics & adolescent medicine YR: 2006 VL: 160 NO: 11 PG: 1121-5 PM: PUBMED 17088514 XR: EMBASE 2006550252 PT: Journal Article; Randomized Controlled Trial AD: Departments of General Practice and Dermatology, Maastricht University, 6200 MD Maastricht, the Netherlands. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/484/CN00573484/frame.html KY: Adhesives; Bandages [adverse effects]; Prospective Studies; Treatment Failure; Warts [therapy]; Child; Child, Preschool; Female; Humans; Male CO: Comment in: Arch Pediatr Adolesc Med. 2006 Nov;160(11):1126-9. PMID: 17088515. Comment in: Arch Pediatr Adolesc Med. 2007 May;161(5):518-9. PMID: 17485633. Comment in: J Fam Pract. 2007 Feb;56(2):97. PMID: 17607825. Comment in: J Pediatr. 2007 May;150(5):563-4. PMID: 17452242. AB: OBJECTIVE: To determine the efficacy of duct tape compared with placebo in the treatment of verruca vulgaris. DESIGN AND SETTING: A randomized placebocontrolled trial in 3 primary schools in Maastricht, the Netherlands. PARTICIPANTS: One hundred three children aged 4 to 12 years with verruca vulgaris. INTERVENTIONS: Duct tape applied to the wart or placebo, a corn pad (protection ring for clavi), applied around the wart for 1 night a week. Both treatments were applied for a period of 6 weeks. Patients were blinded to the hypothesis of the study. MAIN OUTCOME MEASUREMENT: Complete resolution of the treated wart. RESULTS: After 6 weeks, the wart had disappeared in 16% of the children in the duct tape group compared with 6% in the placebo group (P = .12). The estimated effect of duct tape compared with placebo on diameter reduction of the treated wart was 1.0 mm (P = .02, 95% confidence interval, -1.7 to -0.1). After 6 weeks, in 7 children (21%) in the duct tape group, a surrounding wart had disappeared compared with 9 children (27%) in the placebo group (P = .79). Fifteen percent of the children in the duct tape group reported adverse effects such as erythema, eczema, and wounds compared with 0 in the placebo group (P = .14). CONCLUSION: In a 6-week trial, duct tape had a modest but nonsignificant effect on wart resolution and diameter reduction when compared with placebo in a cohort of primary school children. Record #13 of 101 ID: CN-00623252 AU: Aum HS AU: Kim YH AU: Kim DH TI: [Study of pulsed dye laser followed by intralesional bleomycin treatment compared to lone intralesional bleomycin treatment for recalcitrant periungual warts] SO: Korean Journal of Dermatology YR: 2006 VL: 44 NO: 1 PG: 45-50 XR: EMBASE 2006156166 PT: Journal: Article DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/252/CN00623252/frame.html KY: Article; Bleeding; Blister; Clinical Article; Clinical Trial; Comparative Study; Controlled Study; Drug Efficacy; Drug Safety; Drug Tolerability; Human; Injection; Nail Disease; Dt [Drug Therapy]; Nail Disease; Et [Etiology]; Nail Disease; Th [Therapy]; *Periungual Wart; Dt [Drug Therapy]; *Periungual Wart; Th [Therapy]; *Pulsed Dye Laser; Randomized Controlled Trial; Side Effect; Si [Side Effect]; Treatment Outcome; *Verruca Vulgaris; Dt [Drug Therapy]; *Verruca Vulgaris; Et [Etiology]; *Verruca Vulgaris; Th [Therapy]; Visual Analog Scale; *Bleomycin; Ae [Adverse Drug Reaction]; *Bleomycin; Ct [Clinical Trial]; *Bleomycin; Dt [Drug Therapy]; *Bleomycin; Il [Intralesional Drug Administration] AB: Background: Viral warts affect 7-10% of the population and are a major burden on time and resources for all dermatology departments. There are currently various treatment modalities available, including cryotherapy, laser therapy, immune therapy, and topical keratolytics. However, some warts have proven to be resistant to these multiple therapies. Bleomycin has shown to be effective on these warts, but its injection can be difficult because of risk of local complications. Objective: We compared the cure rate, efficacy, tolerability, side effects, and practicality of pulsed dye laser immediately followed by intralesional bleomycin treatment compared to treatment by intralesional bleomycin alone. Methods: This study is a randomized controlled trial. Twenty-four patients, all with recalcitrant viral periungual warts of at least 2 years duration, were recruited. Twelve patients were treated with pulsed dye laser followed by intralesional bleomycin injection, and the other 12 patients were treated with intralesional bleomycin injection alone. Results: All warts were cleared in all patients. There was no significant difference in the mean treatment number and the mean number of nail changes between the two groups. However, there was a significant decrease in the VAS score and the size of hemorrhagic blistering, involving the surrounding normal skin, in the combined pulsed dye laser and intralesional bleomycin group. In addition, the combined therapy enabled physicians to inject bleomycin more easily and safely. Conclusion: The combined method of pulsed dye laser and intralesional bleomycin appears to be a safe, effective and well tolerated treatment for recalcitrant periungual warts. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #14 of 101 ID: CN-00565165 AU: Luk NM AU: Tang WY AU: Tang NL AU: Chan SW AU: Wong JK AU: Hon KL AU: Lo KK TI: Topical 5-fluorouracil has no additional benefit in treating common warts with cryotherapy: a single-centre, double-blind, randomized, placebo-controlled trial. SO: Clinical and experimental dermatology YR: 2006 VL: 31 NO: 3 PG: 394-7 PM: PUBMED 16681586 XR: EMBASE 2006154436 PT: Comparative Study; Journal Article; Randomized Controlled Trial AD: Department of Research Centre, The Chinese University of Hong Kong, Hong Kong, China. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/165/CN00565165/frame.html KY: Adolescent; Age Factors; Antiviral Agents [therapeutic use]; Blister [etiology]; Combined Modality Therapy; Cryotherapy [adverse effects]; DoubleBlind Method; Fluorouracil [therapeutic use]; Immunocompromised Host; Pain [etiology]; Regression Analysis; Treatment Failure; Warts [drug therapy] [therapy]; Adult; Aged; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: The role of topical 5-fluorouracil (5-FU) in treating common warts is not well defined. We tried to evaluate the efficacy and adverse effects of combination cryotherapy and topical 5% 5-FU ointment in the treatment of common warts. The study was a single-centre, double-blind randomized placebo-controlled trial. In the study, 80 patients with common warts were randomized into two groups and underwent two 10-second freeze/thaw cycles of cryotherapy with liquid nitrogen once every three weeks for a maximum of five treatments. Between treatments, patients applied either topical 5% 5-FU ointment (group A) or placebo aqueous cream (group B) twice daily. The mean +/- SD reduction in wart area was 58.57 +/- 0.06% in group A and 65.29 +/- 0.06% in group B. In total, 19 patients in group A and 24 patients in group B had wart size reduced by 75% or more (P = 0.50), while 12 patients in group A and 17 patients in group B had clearance of their warts (P = 0.245). Logistic regression with age, sex, smoking status, immune status, site, duration and number of warty lesions, history of previous treatment, and treatment group found that only a history of previous treatment and acral lesions were significant adverse predictors of improvement. There was no significant difference in the number of adverse events between the two groups, although there was a trend towards more pain and blistering associated with topical 5-FU. We concluded that topical 5-FU has no added benefit in treating common warts with cryotherapy. Record #15 of 101 ID: CN-00623193 AU: Akarsu S AU: Ilknur T AU: Demirtasoglu M AU: Ozkan S TI: Verruca vulgaris: Pulsed dye laser therapy compared with salicylic acid + pulsed dye laser therapy. SO: Journal of the European Academy of Dermatology and Venereology YR: 2006 VL: 20 NO: 8 PG: 936-40 XR: EMBASE 2006395614 PT: Journal: Article DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/193/CN00623193/frame.html KY: Adolescent; Adult; Article; Blister; Co [Complication]; Blister; Dt [Drug Therapy]; Blister; Pc [Prevention]; Clinical Article; Clinical Trial; Controlled Study; Cream; Disease Duration; Drug Effect; Female; Human; Hyperkeratosis; Dt [Drug Therapy]; Hyperkeratosis; Pc [Prevention]; Male; Priority Journal; *Pulsed Dye Laser; Randomized Controlled Trial; Regression Analysis; School Child; Skin Injury; Co [Complication]; Skin Injury; Dt [Drug Therapy]; Skin Injury; Pc [Prevention]; Statistical Significance; *Verruca Vulgaris; Dt [Drug Therapy]; *Verruca Vulgaris; Th [Therapy]; Pseudomonic Acid; Dt [Drug Therapy]; *Salicylic Acid; Ct [Clinical Trial]; *Salicylic Acid; Dt [Drug Therapy] AB: Background: In recent years, lasers have been used in verruca therapy and some successful results have been obtained in some types of verruca. In some of these laser studies, peeling processes have been used to increase penetration. Objective: This study aimed to compare the effects of pulsed dye laser (PDL) therapy with the effects of PDL therapy following salicylic acid (SA) application. The purpose of the SA application is to increase the laser penetration by decreasing the hyperkeratosis of verruca vulgaris. Methods: This controlled study included 66 lesions from 19 patients enrolled in the study. PDL was applied to 33 lesions following 30% SA application twice a day for 5 days, and the remaining 33 lesions underwent PDL therapy. PDL was administered in both groups at 4-week intervals varying from one to five sessions. In the comparison of these two groups, the changes in verruca dimensions were recorded in width x length x height (mm3), and the results of the therapy were evaluated statistically. Results: In both PDL and SA + PDL groups, the regressions observed in the size of the lesions were statistically significant at the end of the fifth session compared with those observed at the onset of the therapy (P < 0.05). At the end of the fifth session, the difference between the two groups was not statistically significant (P = 0.451); however, the clearance rate in the SA + PDL group was more statistically significant than that in the PDL group after the second session (P = 0.049). The complete clearance rate in the SA + PDL group was 54.6% after the second session, but 66.4% in the PDL group only after the fifth session. Complete clearance in the SA + PDL group was observed after 2.2 sessions, and in the PDL group after 3.1 sessions (P < 0.05). Conclusions: Although there was no difference between the clearance rate of the SA + PDL group and that of the PDL group after the fifth session, adding SA to PDL decreased the number of sessions to a large extent. copyright 2006 European Academy of Dermatology and Venereology. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #16 of 101 ID: CN-00522063 AU: Smucler R AU: Jatsov· E TI: Comparative study of aminolevulic acid photodynamic therapy plus pulsed dye laser versus pulsed dye laser alone in treatment of viral warts. SO: Photomedicine and laser surgery YR: 2005 VL: 23 NO: 2 PG: 202-5 PM: PUBMED 15910187 PT: Clinical Trial; Controlled Clinical Trial; Journal Article AD: ASKLEPION-Lasercentrum Prague Ltd., Prague, Czech Republic. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/063/CN00522063/frame.html KY: Aminolevulinic Acid [therapeutic use]; Laser Therapy, Low-Level; Patient Satisfaction; Photochemotherapy; Photosensitizing Agents [therapeutic use]; Treatment Outcome; Warts [therapy]; Humans AB: OBJECTIVE AND BACKGROUND: A number of scientific publications describe the removal of viral warts using photoselective laser destruction with pulsed dye laser (PDL) or photodynamic therapy (PDT). Although both methods represent an enormous improvement in therapy, the results are not sufficiently consistent to consider these methods as the "gold standard" for therapy. METHODS: With a view to further improvement we combined a photoselective dye laser (595 nm, 20 J.cm(2)) with photodynamic therapy using aminolevulic acid. The results of this method were compared against traditional laser photodestruction (of identical physical parameters) and against traditional photodynamic therapy (of similar parameters). RESULTS: After combined therapy (PDT + PDL) of 86 warts in 24 patients, 100% were cured, with an average of 1.96 therapeutic sessions. Therapy with PDT alone failed in 3 of 76 warts even after 5 sessions (96%), with an average of 2.54 therapeutic sessions. Therapy with PDL alone failed in 21 of 112 warts even after 5 sessions, with an average of 3.34 therapeutic sessions. CONCLUSIONS: All three therapeutic methods are able to cure infectious warts with high probability (>80%). However, a combination of PDT and PDL is the most effective and the most favored therapy. If other investigators also confirm results near or equal to 100% success, this therapy could become a treatment of choice for this indication. Record #17 of 101 ID: CN-00503061 AU: Harwood CA AU: Perrett CM AU: Brown VL AU: Leigh IM AU: McGregor JM AU: Proby CM TI: Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals. SO: The British journal of dermatology YR: 2005 VL: 152 NO: 1 PG: 122-9 PM: PUBMED 15656812 PT: Clinical Trial; Controlled Clinical Trial; Journal Article AD: Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, 2 Newark Street, London, E1 2AT, UK. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/061/CN00503061/frame.html KY: Administration, Cutaneous; Adolescent; Aminoquinolines [adverse effects] [therapeutic use]; Antiviral Agents [adverse effects] [therapeutic use]; FollowUp Studies; Foot Dermatoses [drug therapy] [pathology] [virology]; Hand Dermatoses [drug therapy] [pathology] [virology]; Immunocompromised Host; Interferon Inducers [adverse effects] [therapeutic use]; Kidney Transplantation [immunology]; Liver Transplantation [immunology]; Prospective Studies; Recurrence; Self Administration; Treatment Outcome; Warts [drug therapy] [immunology] [pathology]; Adult; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: BACKGROUND: Viral warts may cause significant morbidity in individuals unable to mount an adequate T-helper 1 cell-mediated immune response to human papillomavirus. Imiquimod is a potent inducer of antiviral cytokine activity which has shown significant efficacy in the treatment of genital warts. Similar efficacy in cutaneous warts is not yet established. OBJECTIVES: To assess the response of persistent cutaneous warts to 5% imiquimod cream in immunosuppressed individuals. METHODS: Fifteen immunosuppressed patients with warts on the hands and/or feet present for more than 18 months, which had failed to respond to a minimum of 12 weeks of topical salicylic acid and four cycles of cryotherapy, were recruited. Imiquimod 5% cream was applied in an open label, right vs. left comparison study for 24 weeks (three times weekly for 8 weeks, daily for 8 weeks, then daily with occlusion for 8 weeks). RESULTS: Twelve (80%) patients completed the study protocol. Benefit was seen in five patients [36% in the intent-to-treat analysis (14 patients)], including more than 30% clearance of warts in three patients and reduction in overall size of warts in two further cases. Local skin reactions occurred in four (29%) patients and were usually mild. A transient rise in creatinine (11-29% above baseline) was measured in three renal transplant recipients, but we did not consider that this was related to imiquimod exposure. CONCLUSIONS: This is the first controlled study to assess therapeutic efficacy of topical 5% imiquimod cream in persistent warts associated with immunosuppression. It provides preliminary evidence that topical imiquimod may benefit a subgroup of immunosuppressed patients with recalcitrant cutaneous warts. Record #18 of 101 ID: CN-00511848 AU: Horn TD AU: Johnson SM AU: Helm RM AU: Roberson PK TI: Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial. SO: Archives of dermatology YR: 2005 VL: 141 NO: 5 PG: 589-94 PM: PUBMED 15897380 XR: EMBASE 2005214484 PT: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. AD: Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/848/CN00511848/frame.html KY: Antigens, Fungal [administration & dosage] [adverse effects] [therapeutic use]; Antigens, Viral [administration & dosage] [adverse effects] [therapeutic use]; Antiviral Agents [adverse effects] [therapeutic use]; Candida [immunology]; Cell Division [drug effects]; Granulocyte-Macrophage ColonyStimulating Factor [therapeutic use]; Histocompatibility Antigens [blood]; Immunotherapy [adverse effects] [methods]; Injections, Intralesional; Interferon Alfa-2b [adverse effects] [therapeutic use]; Monocytes [pathology]; Mumps virus [immunology]; Papillomaviridae [immunology]; Treatment Outcome; Trichophyton [immunology]; Warts [drug therapy] [therapy]; Adult; Female; Humans; Male CC: SR-SKIN AB: BACKGROUND: Warts occur commonly in humans. Destructive modalities are generally the first physician-administered therapy. Other treatment options include immunotherapy. Intralesional immunotherapy using mumps, Candida, or Trichophyton skin test antigens has proved efficacy in the treatment of warts. OBJECTIVES: To determine rates of wart resolution in response to injection of antigen alone, antigen plus interferon alfa-2b, interferon alfa-2b alone, and normal saline; and to compare response according to viral type, major histocompatibility complex antigens, and peripheral blood mononuclear cell proliferation to autologous human papillomavirus antigen before and after injection. DESIGN: Randomized, single-blinded, placebo-controlled, clinical trial. SETTING: Medical school-based dermatology department. PATIENTS: Two hundred thirty-three patients clinically diagnosed as having 1 or more warts.Main Outcome Measure Clinical resolution of warts in response to intralesional immunotherapy. RESULTS: Responders were observed in all treatment arms, but were significantly more likely to have received antigen (P<.001). Resolution of distant untreated warts was observed, and was significantly more likely in subjects receiving antigen (P<.001). Interferon did not significantly enhance the response rate (P = .20) and did not differ from normal saline (P = .65). No viral type or major histocompatibility complex antigen correlated with response or lack of response (P>.99 and P = .86, respectively). A positive peripheral blood mononuclear cell proliferation assay result (2 times pretreatment levels) was significantly more likely among responders (P = .002). While there was no significant difference in response based on sex (P = .56), older subjects (>40 years) were less likely to respond (P = .01). CONCLUSIONS: Intralesional immunotherapy using injection of Candida, mumps, or Trichophyton skin test antigens is an effective treatment for warts, as indicated by significantly higher response rates and distant response rates in subjects receiving antigen. Viral type and major histocompatibility complex antigens did not seem to influence treatment response. Response is accompanied by proliferation of peripheral blood mononuclear cells to human papillomavirus antigens, suggesting that a human papillomavirus-directed cell-mediated immune response plays a role in wart resolution. Record #19 of 101 ID: CN-00504934 AU: Gach JE AU: Humphreys F AU: Berth-Jones J TI: Randomized, double-blind, placebo-controlled pilot study to assess the value of free radical scavengers in reducing inflammation induced by cryotherapy. SO: Clinical and experimental dermatology YR: 2005 VL: 30 NO: 1 PG: 14-6 PM: PUBMED 15663493 XR: EMBASE 2005061864 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Walsgrave Hospital, Coventry, UK. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/934/CN00504934/frame.html KY: Adolescent; Ascorbic Acid [administration & dosage]; Blister [etiology]; Cryotherapy [adverse effects]; Dermatitis [etiology] [prevention & control]; Double-Blind Method; Edema [etiology]; Erythema [etiology]; Pain, Postoperative [etiology]; Pilot Projects; Vitamin E [administration & dosage]; Warts [therapy]; Adult; Aged; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: The inflammation which follows cryotherapy is a significant disadvantage of this therapeutic modality. To date, the only treatment shown to reduce this inflammation is application of topical corticoids. We have therefore conducted a pilot study to investigate whether pretreatment with the free radical scavengers, vitamins C and E might alleviate the signs and symptoms of inflammation following liquid nitrogen cryotherapy of common warts. We undertook a randomized, double-blind, placebo-controlled, parallel group study. We recruited 40 adult patients, of whom 38 returned for evaluation. Treatments comprised vitamin C (2000 mg) and vitamin E (800 IU) daily or matching placebo for 7 days prior to cryotherapy to a hand wart. Oedema volume, erythema level, pain intensity and the presence or absence of blistering were assessed 24 h after cryotherapy. There were no significant differences between the two treatment groups in any of the parameters assessed. This study yielded no suggestion of benefit from the use of pretreatment with free radical scavengers in conjunction with liquid nitrogen cryotherapy. Record #20 of 101 ID: CN-00569602 AU: Chapman MS AU: Schachner LA AU: Breneman D AU: Boguniewicz M AU: Gold MH AU: Shull T AU: Linowski GJ AU: Jaracz E TI: Tacrolimus ointment 0.03% shows efficacy and safety in pediatric and adult patients with mild to moderate atopic dermatitis. SO: Journal of the American Academy of Dermatology YR: 2005 VL: 53 NO: 2 Suppl 2 PG: S177-S185 XR: EMBASE 2005311783 PT: Journal: Article DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/602/CN00569602/frame.html KY: *Tsukubaenolide; Ae [Adverse Drug Reaction]; *Tsukubaenolide; Dt [Drug Therapy]; *Tsukubaenolide; Tp [Topical Drug Administration]; *Atopic Dermatitis; Dt [Drug Therapy]; Drug Efficacy; Drug Safety; Ointment; Treatment Outcome; Rating Scale; Pruritus; Si [Side Effect]; Burning Sensation; Si [Side Effect]; Stinging Sensation; Si [Side Effect]; Pain; Si [Side Effect]; Erythema; Si [Side Effect]; Herpes Simplex; Si [Side Effect]; Verruca Vulgaris; Si [Side Effect]; Viral Skin Disease; Si [Side Effect]; Herpes Zoster; Si [Side Effect]; Folliculitis; Si [Side Effect]; Acne; Si [Side Effect]; Human; Male; Female; Adolescent; Aged; Child; Adult; Article; Priority Journal CC: SR-SKIN AB: Background/Objective: Tacrolimus ointment is approved for the treatment of moderate to severe atopic dermatitis (AD). We sought to evaluate the efficacy and safety of tacrolimus ointment 0.03% compared with vehicle in the treatment of patients with mild to moderate AD. Methods: Two identically designed, independent, randomized, double-blind, 6-week studies - one pediatric and one adult - in patients with mild to moderate AD were conducted. Combined data from 617 patients were used in the analysis. The primary efficacy end point was percentage of patients with treatment success (defined as 'clear' or 'almost clear' on the Investigator's Global AD Assessment) at end of study. Results: As early as day 4, treatment success occurred in 17.7% of patients treated with tacrolimus compared with 9.8% of patients treated with vehicle (P = .003), and by study end had increased to 49.7% for tacrolimus versus 29.0% for vehicle (P < .0001). Tacrolimus was associated with significantly less application site pruritus than vehicle (29.0% vs 37.5%; P = .03). There was no difference between tacrolimus and vehicle in the incidence of application site skin burning and stinging. Conclusion: Tacrolimus ointment 0.03% is effective and safe for the management of mild to moderate AD in both adult and pediatric patients, and has a rapid onset of action. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #21 of 101 ID: CN-00602479 AU: Erbagci Z,Tuncel A TI: Therapeutic efficacy of topical imiquimod in recalcitrant cutaneous warts. Abstract P08.68. The 14th Congress of the European Academy of Dermatology and Venereology, London,UK. 12-15th October 2005. SO: Journal of the European Academy of Dermatology & Venereology YR: 2005 VL: 19 NO: Suppl 2 PG: 236 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/479/CN00602479/frame.html CC: SR-SKIN Record #22 of 101 ID: CN-00516883 AU: Salk RS TI: 5-Fluorouracil 5% cream for cutaneous warts: clinical trial preliminary data. SO: Cosmetic Dermatology YR: 2004 VL: 17 NO: 11 Suppl 3 PG: 3-6 XR: EMBASE 2004496791 PT: Journal: Article DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/883/CN00516883/frame.html KY: *Fluorouracil; Ct [Clinical Trial]; *Fluorouracil; Dt [Drug Therapy]; *Fluorouracil; Iv [Intravenous Drug Administration]; *Fluorouracil; Tp [Topical Drug Administration]; *Verruca Vulgaris; Dt [Drug Therapy]; *Verruca Plantaris; Dt [Drug Therapy]; Follow up; Treatment Outcome; Pain; Bandage; Cream; Human; Clinical Article; Clinical Trial; Randomized Controlled Trial; Controlled Study; Adult; Article AB: Plantar warts are a common affliction in children and adolescents and present a treatment challenge for the dermatologist. Currently available treatment modalities, such as laser therapy, curettage, and cryotherapy, have high rates of recurrence and often result in pain and scarring. Occlusion with duct tape has been studied in pediatric patients with promising results, and efficacy of 5-fluorouracil (5-FU) 5% cream has been reported in the literature, but as anecdotal evidence. This article presents preliminary results from a well-controlled, randomized clinical trial of 5-FU 5% cream (Efudex) plus tape occlusion versus tape occlusion alone. All 20 evaluable patients who received combination therapy were clinically clear of warts by week 12, compared with 2 of 20 patients who received tape occlusion alone. Follow-up at 3 and 6 months supports the clinical efficacy and high remission rate of 5-FU 5% cream. Combination therapy has been well tolerated by patients, with minimal or no pain during treatment. Final results from this trial will be available early next year, and are expected to confirm superior efficacy of 5-FU 5% cream with tape occlusion compared with tape occlusion alone. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #23 of 101 ID: CN-00509779 AU: Yazdanfar A et al TI: A comparative study on the efficacy of intralesional injections of bleomycin and normal saline in the treatment of recalcitrant common warts on palm and dorsum of hand. SO: Iranian Journal of Dermatology YR: 2003 VL: 7 NO: 1 PG: 1 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/779/CN00509779/frame.html CC: SR-SKIN Record #24 of 101 ID: CN-00594068 AU: Buccolo LS AU: Moore TK TI: Duct tape occlusion for common warts: is effectiveness overestimated? SO: Archives of pediatrics and adolescent medicine YR: 2003 VL: 157 NO: 5 PG: 491-2 PT: Comment DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/068/CN00594068/frame.html KY: Adhesives; Child; Cryotherapy; Human; Reproducibility of Results; therapy; Warts CC: HS-HANDSRCH; SR-CHILD Record #25 of 101 ID: CN-00475239 AU: Buchanan J AU: Nieland-Fisher NS TI: Duct tape vs cryotherapy in the treatment of Verruca Vulgaris SO: Arch.Pediatr Adolesc.Med. YR: 2003 VL: 157 NO: 5 PG: 490 PT: Comment DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/239/CN00475239/frame.html KY: Adhesives; Human; immunology; Immunotherapy; Methods; therapy; Warts CC: HS-HANDSRCH Record #26 of 101 ID: CN-00454739 AU: Valikhani M et al TI: Efficacy of 5% 5-fluorouracil ointment in comparison with cryotherapy in the treatment of common warts of hands (Persian) SO: Iranian Journal of Dermatology YR: 2002 VL: 5 NO: 4 PG: 3 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/739/CN00454739/frame.html CC: SR-SKIN Record #27 of 101 ID: CN-00454100 AU: Blancas F et al TI: Homeopathic Thuja Occidentalis vs Placebo in Common Warts Abstract SO: 20th World Congress of Dermatology Paris 1st to 5th July 2002 YR: 2002 PG: P1647 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/100/CN00454100/frame.html CC: SR-COMPMED; SR-SKIN Record #28 of 101 ID: CN-00593302 AU: Ringold S AU: Mendoza JA AU: Tarini BA AU: Sox C TI: Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? SO: Archives of pediatrics and adolescent medicine YR: 2002 VL: 156 NO: 10 PG: 975-977 PT: Comment DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/302/CN00593302/frame.html KY: Cryotherapy; therapy CC: HS-HANDSRCH; SR-CHILD AB: letter Record #29 of 101 ID: CN-00430850 AU: Hutchinson PE AU: Bleiker TO TI: Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud. SO: The British journal of dermatology YR: 2002 VL: 146 NO: 6 PG: 1110; author reply 1110 PM: PUBMED 12072095 PT: Clinical Trial; Comment; Letter; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/850/CN00430850/frame.html KY: Administration, Topical; Cryotherapy [methods]; Gossypium; Nitrogen [administration & dosage]; Warts [therapy]; Humans CO: Comment on: Br J Dermatol. 2001 May;144(5):1006-9. PMID: 11359389. CC: HS-HANDSRCH; SR-SKIN Record #30 of 101 ID: CN-00410352 AU: Focht DR AU: Spicer C AU: Fairchok MP TI: The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). SO: Archives of pediatrics & adolescent medicine YR: 2002 VL: 156 NO: 10 PG: 971-4 PM: PUBMED 12361440 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/352/CN00410352/frame.html KY: Adhesives; Adolescent; Bandages; Cryotherapy; Prospective Studies; Treatment Outcome; Warts [therapy]; Adult; Child; Child, Preschool; Female; Humans; Male CO: Comment in: Arch Pediatr Adolesc Med. 2002 Oct;156(10):975-7. PMID: 12361441. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):489-90; author reply 491-2. PMID: 12742888. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):490. PMID: 12742891. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):490. PMID: 12742889. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):490-1; author reply 491-2. PMID: 12742890. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):491. PMID: 12742893. Comment in: Arch Pediatr Adolesc Med. 2003 May;157(5):491; author reply 491-2. PMID: 12742892. Comment in: Arch Pediatr Adolesc Med. 2007 May;161(5):518-9. PMID: 17485633. Comment in: J Fam Pract. 2003 Feb;52(2):111-2. PMID: 12585986. CC: SR-CHILD; SR-SKIN AB: OBJECTIVE: To determine if application of duct tape is as effective as cryotherapy in the treatment of common warts. DESIGN: A prospective, randomized controlled trial with 2 treatment arms for warts in children. SETTING: The general pediatric and adolescent clinics at a military medical center. PATIENTS: A total of 61 patients (age range, 3-22 years) were enrolled in the study from October 31, 2000, to July 25, 2001; 51 patients completed the study and were available for analysis. INTERVENTION: Patients were randomized using computergenerated codes to receive either cryotherapy (liquid nitrogen applied to each wart for 10 seconds every 2-3 weeks) for a maximum of 6 treatments or duct tape occlusion (applied directly to the wart) for a maximum of 2 months. Patients had their warts measured at baseline and with return visits. MAIN OUTCOME MEASURE: Complete resolution of the wart being studied. RESULTS: Of the 51 patients completing the study, 26 (51%) were treated with duct tape, and 25 (49%) were treated with cryotherapy. Twenty-two patients (85%) in the duct tape arm vs 15 patients (60%) enrolled in the cryotherapy arm had complete resolution of their warts (P =.05 by chi(2) analysis). The majority of warts that responded to either therapy did so within the first month of treatment. CONCLUSION: Duct tape occlusion therapy was significantly more effective than cryotherapy for treatment of the common wart. Record #31 of 101 ID: CN-00412356 TI: Treating warts: is duct tape the answer? SO: Child health alert YR: 2002 VL: 20 PG: 4 PM: PUBMED 12523279 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/356/CN00412356/frame.html KY: Adolescent; Bandages; Cryotherapy [methods]; Follow-Up Studies; Nitrogen [therapeutic use]; Reference Values; Skin Diseases [diagnosis] [therapy]; Treatment Outcome; Warts [diagnosis] [therapy]; Adult; Child; Child, Preschool; Female; Humans; Male CC: SR-CHILD Record #32 of 101 ID: CN-00640882 AU: Villeda LL AU: Dorantes GL AU: Gonzalez FB TI: [Homeopathic Thuja occidentalis vs placebo in common warts] OT: Thuja occidentalis homeopatica vs placebo en verrugas vulgares. SO: Dermatologia Revista Mexicana YR: 2001 VL: 45 NO: 1 PG: 14-8 XR: EMBASE 2007502820 PT: Journal: Conference Paper DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/882/CN00640882/frame.html KY: Adolescent; Adult; Child; Clinical Article; Clinical Trial; Conference Paper; Controlled Study; Demography; Double Blind Procedure; Female; Homeopathy; Human; Male; Treatment Outcome; Treatment Response; *Verruca Vulgaris; Dt [Drug Therapy]; *Cedar Leaf Oil; Ct [Clinical Trial]; *Cedar Leaf Oil; Dt [Drug Therapy]; Placebo CC: SR-COMPMED AB: Background: Incremented consultations in complementary and alternativemedicine clinics are a medico-social phenomenon which reflects the cultural changes of the present times. There has been an increase in the number of studies done to evaluate the possible usefulness of these new therapies, specially in the field of homeopathy. Thuja occidentalis (white cedar) has shown antiviral and immunomodulating effects. Objective: To evaluate the homeopathic effect of Thuja occidentalis in the treatment of common warts. Material and methods: A comparative double-blind study was designed with a total of 26 patients with common warts. Patients were divided into two groups. Group A, with 12 patients, received T. occidentalis at the 6 th c.H. dilution. Group B, with 14 patients, was given placebo. There was a similitude in both groups for the variables of sex, age, topography, time of duration and size of lesions. Results: A tendency to improvement was observed in the group that received T. occidentalis; in this group one patient showed total remission of the lesions. None of the patients in the placebo group showed remission of lesions. However, half of the patients in each group showed any response at all. Conclusions: There is a need of performing studies with bigger samples and more orthodox homeopathic criteria. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #33 of 101 ID: CN-00348017 AU: Ahmed I AU: Agarwal S AU: Ilchyshyn A AU: Charles-Holmes S AU: Berth-Jones J TI: Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud. SO: The British journal of dermatology YR: 2001 VL: 144 NO: 5 PG: 1006-9 PM: PUBMED 11359389 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article AD: Department of Dermatology, University Hospitals, Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, U.K. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/017/CN00348017/frame.html KY: Adolescent; Aerosols; Cryosurgery [methods]; Foot Dermatoses [surgery]; Gossypium; Hand Dermatoses [surgery]; Nitrogen [administration & dosage]; Prospective Studies; Treatment Outcome; Warts [surgery]; Adult; Aged; Child; Child, Preschool; Female; Humans; Male; Middle Aged CO: Comment in: Br J Dermatol. 2002 Feb;146(2):341; author reply 341-2. PMID: 11903262. Comment in: Br J Dermatol. 2002 Jun;146(6):1110; author reply 1110. PMID: 12072095. CC: SR-SKIN AB: BACKGROUND: Viral warts represent a large workload for dermatology departments. Cryotherapy with liquid nitrogen is the most widely used method of treatment by dermatologists and is increasingly used by general practitioners in the U.K. Existing data relating to the response to cryotherapy are virtually all derived from the use of a cotton wool bud as the applicator. There is an increasing trend to use the cryo-spray to freeze warts and it has been assumed that this is equally effective. In view of the workload involved it is important to test this assumption. OBJECTIVES: This prospective study was undertaken to compare these two methods of liquid nitrogen cryotherapy with regards to cure rate after 3 months of treatment. METHODS: Patients referred to two hospital dermatology departments with hand or foot warts were allocated to have liquid nitrogen applied with either a cryo-spray or with a cotton wool bud. Using either technique, liquid nitrogen was applied until ice-ball formation had spread from the centre to include a margin of 2 mm around each wart. Treatment was done fortnightly for up to 3 months. Plantar warts were pared and treated with a double freeze-thaw cycle. The endpoint of the study was complete clearance of all warts. RESULTS: Three hundred and sixty-three patients were enrolled, mean age 21 years (range 3-75), 188 male and 175 female. The mean duration of the warts was 98 weeks (median 78, range 2-936). The number of warts on the hands and feet varied from one to 80 (mean 5). The treatment groups were comparable with regards to baseline demographics. Two hundred and seven patients were evaluable. Cure rates at 3 months were 47% in the cotton wool bud group and 44% in the cryo-spray group (P = 0.8). Warts that had been present for 6 months or less (n = 31) had a greater chance of clearance (84%) compared with warts that had been present for more than 6 months (39%, n = 176) (P < 0.0005). CONCLUSIONS: Cryotherapy with liquid nitrogen for hand and foot warts in our study was equally effective when applied with a cotton wool bud or by means of a spray. Record #34 of 101 ID: CN-00354373 AU: Whitaker JM AU: Gaggero GL AU: Loveland L AU: Segura L AU: Barbosa P TI: Plantar verrucae in patients with human immunodeficiency virus. Clinical presentation and treatment response. SO: Journal of the American Podiatric Medical Association YR: 2001 VL: 91 NO: 2 PG: 79-84 PM: PUBMED 11266482 PT: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AD: California College of Podiatric Medicine, San Francisco, USA. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/373/CN00354373/frame.html KY: Collodion [therapeutic use]; Curettage; Dermatologic Agents [therapeutic use]; Drug Combinations; Foot Diseases [complications] [therapy]; HIV Seronegativity; HIV Seropositivity [complications]; Lactates [therapeutic use]; Pilot Projects; Salicylic Acids [therapeutic use]; San Francisco; Treatment Outcome; Warts [complications] [therapy]; Humans AB: Several previous studies have yielded data showing that plantar and other cutaneous verrucae follow a more aggressive course in patients infected with human immunodeficiency virus (HIV) than in uninfected individuals. A pilot study was undertaken to identify trends in a sample population that would support this characterization of plantar verrucae in HIV+ patients and to determine whether there are differences in treatment response between HIV+ and HIV- patients. The results show that the HIV+ patients in the study presented with a significantly greater number and total area of lesions than did the HIV- patients. Furthermore, the HIV+ patients experienced a greater frequency of recurrence of their lesions following treatment with surgical curettage. These findings should provide the foundation for other extensive, multicenter studies to further characterize the treatment response of these lesions in HIV+ patients and to develop effective guidelines for their management. Record #35 of 101 ID: CN-00356695 AU: Bhat RM AU: Vidya K AU: Kamath G TI: Topical formic acid puncture technique for the treatment of common warts. SO: International journal of dermatology YR: 2001 VL: 40 NO: 6 PG: 415-9 PM: PUBMED 11589750 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article AD: Department of Dermatology and Venereology, Father Muller's Medical College Hospital, Kankanady, Mangalore, Karnataka State, India. [email protected] US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/695/CN00356695/frame.html KY: Administration, Topical; Adolescent; Dermatology [methods]; Drug Administration Schedule; Follow-Up Studies; Formic Acids [administration & dosage]; Punctures; Reference Values; Treatment Outcome; Warts [diagnosis] [drug therapy]; Adult; Child; Female; Humans; Male; Middle Aged AB: BACKGROUND: Warts are a common chronic skin disorder that can be cosmetically disfiguring and, depending on the location, cause inhibition of function. The presence of dozens of topical and systemic treatments for warts is a testament to the lack of a rapid, simple, uniformly effective, inexpensive, nonscarring, and painless treatment. AIM: The purpose of this study was to determine the efficacy and safety of 85% formic acid application, an inexpensive therapy, for the treatment of warts. METHODS: A placebo-controlled, nonrandomized, open trial was performed in 100 patients with common warts attending Father Muller's Medical College Hospital, Mangalore. Fifty patients received 85% formic acid application and 50 patients received placebo (water) using a topical application/needle puncture technique every other day. RESULTS: Ninety-two per cent of patients who received formic acid application showed complete disappearance of warts after a 3-4-week treatment period, compared to 6% in the placebo group. CONCLUSIONS: The results show that 85% formic acid application is a safe, economical, and effective alternative in the treatment of common warts with few side-effects and good compliance. A multicenter trial is needed to examine the efficacy and safety of this treatment. Record #36 of 101 ID: CN-00425868 AU: Iscimen A AU: Goksugur N AU: Unal G AU: Aydemir EH TI: Treatment of verrucae vulgaris with intralesional 5-fluorouracil. OT: VERRUKA TEDAVISINDE 5-FLUOROURASIL'IN INTRALEZYONEL KULLANIMI: PLASEBO KONTROLLU TEK KOR CALISMA. SO: Deri Hastaliklari Ve Frengi Arsivi YR: 2001 VL: 35 NO: 3 PG: 199-203 XR: EMBASE 2002240346 PT: Journal: Article DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/868/CN00425868/frame.html KY: *Verruca Vulgaris/Dt [Drug Therapy]; Cytostasis; Squamous Cell; Drug Efficacy; Pain/Si [Side Effect]; Skin Manifestation/Si [Side Effect]; Remission; Chi Square Distribution; Drug Safety; Scar Formation/Si [Side Effect]; Pigment Disorder/Si [Side Effect]; Human; Male; Female; Major Clinical Study; Clinical Trial; Randomized Controlled Trial; Controlled Study; Adolescent; Adult; Article; *Fluorouracil/Ae [Adverse Drug Reaction]; *Fluorouracil/Ct [Clinical Trial]; *Fluorouracil/Cb [Drug Combination]; *Fluorouracil/Cm [Drug Comparison]; *Fluorouracil/Dt [Drug Therapy]; *Fluorouracil/Il [Intralesional Drug Administration]; Lidocaine/Ae [Adverse Drug Reaction]; Lidocaine/Ct [Clinical Trial]; Lidocaine/Cb [Drug Combination]; Lidocaine/Cm [Drug Comparison]; Lidocaine/Dt [Drug Therapy]; Lidocaine/Il [Intralesional Drug Administration]; Adrenalin/Ae [Adverse Drug Reaction]; Adrenalin/Ct [Clinical Trial]; Adrenalin/Cb [Drug Combination]; Adrenalin/Cm [Drug Comparison]; Adrenalin/Dt [Drug Therapy]; Adrenalin/Il [Intralesional Drug Administration]; Placebo AB: Background and design: There are many treatment modalities for the therapy of common warts. The cytocytatic drug 5-FU has been found to selectively affect squamous cell, but the method of its delivery directly into affected tissue such as warts has been of limited efficacy. This study is designed to assess the efficacy of intralesional administration of 5-FU. Materials and methods: Eightysix patients (47 female, 39 male; mean age 23.4 years, range 16-48) who had warts more than one were entered into study (mean number of lesions: 3.1; range 2-6.). Thus placebo and therapeutic agent could be applied to the same patient. Each lesion was injected once a week for up to 4 weeks, and patients were evaluated at first and second months after the last injection. Pain and cutaneous reactions were noted. The patients were randomized into two groups; 5FU with placebo and lidocaine+adrenalin/5-FU with placebo. Results: Of the 45 patients who applied 5-FU, 26 went into full remission, 13 partially and 6 not responded. In second group (lidocaine+adrenalin/5-FU), of the 41 patients, 25 went into full remission, 9 partially and 7 not responded. Especially mosaic verrucae were well responded to the therapy. Statistical analyses was performed with chi-square test. Both 5-FU and lidocaine+adrenalin/5-FU treatments were effective: both were superior to placebo (p< 0.001). But the effects of the both treatments was not significantly different from each other (p>0.05). Scarring and pigmentary changes at injection sites were minimal. No systemic side effects were observed. Conclusion: Intralesional administration of 5-FU with or without lidocaine proved to be an effective method in more than half of the patients with verrucae. Number of References 20. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #37 of 101 ID: CN-00277571 AU: Harkness EF AU: Abbot NC AU: Ernst E TI: A randomized trial of distant healing for skin warts. SO: The American journal of medicine YR: 2000 VL: 108 NO: 6 PG: 448-52 PM: PUBMED 10781776 PT: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AD: Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, United Kingdom. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/571/CN00277571/frame.html KY: Anxiety [etiology] [psychology]; Attitude to Health; Depression [etiology] [psychology]; Double-Blind Method; Mental Healing; Questionnaires; Telepathy; Treatment Outcome; Warts [psychology] [therapy]; Wound Healing; Adult; Female; Humans; Male; Middle Aged CO: Comment in: Am J Med. 2000 Apr 15;108(6):507-8. PMID: 10781788. CC: SR-COMPMED AB: PURPOSE: Distant healing, a treatment that is transmitted by a healer to a patient at another location, is widely used, although good scientific evidence of its efficacy is sparse. This trial was aimed at assessing the efficacy of one form of distant healing on common skin warts. SUBJECTS AND METHODS: A total of 84 patients with warts were randomly assigned either to a group that received 6 weeks of distant healing by one of 10 experienced healers or to a control group that received a similar preliminary assessment but no distant healing. The primary outcomes were the number of warts and their mean size at the end of the treatment period. Secondary outcomes were the change in Hospital Anxiety and Depression Scale and patients' subjective experiences. Both the patients and the evaluator were blinded to group assignment. RESULTS: The baseline characteristics of the patients were similar in the distant healing (n = 41) and control groups (n = 43). The mean number and size of warts per person did not change significantly during the study. The number of warts increased by 0.2 in the healing group and decreased by 1.1 in the control group (difference [healing to control] = -1.3; 95% confidence interval = -1.0 to 3.6, P = 0.25). Six patients in the distant healing group and 8 in the control group reported a subjective improvement (P = 0.63). There were no significant between-group differences in the depression and anxiety scores. CONCLUSION: Distant healing from experienced healers had no effect on the number or size of patients' warts. Record #38 of 101 ID: CN-00466212 AU: Robson KJ AU: Cunningham NM AU: Kruzan KL AU: Patel DS AU: Kreiter CD AU: O'Donnell MJ AU: Arpey CJ TI: Pulsed-dye laser versus conventional therapy in the treatment of warts: a prospective randomized trial. Review 24 refs SO: Journal of the American Academy of Dermatology YR: 2000 VL: 43 NO: 2 (Pt 1) PG: 275-80 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/212/CN00466212/frame.html CC: SR-SKIN AB: BACKGROUND: The clinical management of verrucae vulgaris is often challenging, and no ideal treatment currently exists. Early studies suggested that pulsed-dye laser (PDL) therapy might be highly effective in the treatment of verrucae, although more recent reports have been less optimistic. Previous studies have been retrospective or have consisted of a series of patients treated with PDL alone. OBJECTIVE: Our objective was to prospectively evaluate the efficacy of PDL therapy versus conventional therapy with liquid nitrogen cryotherapy or cantharidin in the treatment of warts. METHODS: Forty healthy adult patients with verrucae were randomized to receive either PDL (585 nm) therapy or conventional therapy. All enrollees also performed home therapy. Patients were eligible for up to 4 treatment sessions at 1-month intervals. Warts were individually counted and measured at the time of each treatment session. Complete response was defined as complete absence of verrucae with the presence of dermatoglyphics, and partial response was defined as a 50% or greater reduction in wart size. RESULTS: A total of 194 warts were evaluated by the conclusion of the study. Complete response was noted in an average of 70% of the warts treated with conventional therapy and in 66% of those in the PDL group; this was statistically insignificant. Partial response was observed in an average of 82% of the warts in patients treated with conventional therapy and 87% in the PDL group. Verruca vulgaris responded more readily than verruca plantaris in both treatment groups. The mean number of treatments to achieve success was similar in both groups. CONCLUSION: The PDL is an efficacious form of therapy for verrucae, as is conventional therapy. PDL therapy should be considered among the better established approaches in the treatment of warts, although data from this trial suggest that this approach is probably not superior. [References: 24] Record #39 of 101 ID: CN-00298475 AU: Robson KJ AU: Cunningham NM AU: Kruzan KL AU: Patel DS AU: Kreiter CD AU: O'Donnell MJ AU: Arpey CJ TI: Pulsed-dye laser versus conventional therapy in the treatment of warts: a prospective randomized trial. SO: Journal of the American Academy of Dermatology YR: 2000 VL: 43 NO: 2 Pt 1 PG: 275-80 PM: PUBMED 10906651 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Review AD: Department of Dermatology and the Office of Consultation and Research in Medical Education, University of Iowa Hospitals and Clinics, Iowa City 52242, USA. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/475/CN00298475/frame.html KY: Cantharidin [therapeutic use]; Cryotherapy; Laser Therapy; Prospective Studies; Warts [therapy]; Adult; Female; Humans; Male AB: BACKGROUND: The clinical management of verrucae vulgaris is often challenging, and no ideal treatment currently exists. Early studies suggested that pulsed-dye laser (PDL) therapy might be highly effective in the treatment of verrucae, although more recent reports have been less optimistic. Previous studies have been retrospective or have consisted of a series of patients treated with PDL alone. OBJECTIVE: Our objective was to prospectively evaluate the efficacy of PDL therapy versus conventional therapy with liquid nitrogen cryotherapy or cantharidin in the treatment of warts. METHODS: Forty healthy adult patients with verrucae were randomized to receive either PDL (585 nm) therapy or conventional therapy. All enrollees also performed home therapy. Patients were eligible for up to 4 treatment sessions at 1-month intervals. Warts were individually counted and measured at the time of each treatment session. Complete response was defined as complete absence of verrucae with the presence of dermatoglyphics, and partial response was defined as a 50% or greater reduction in wart size. RESULTS: A total of 194 warts were evaluated by the conclusion of the study. Complete response was noted in an average of 70% of the warts treated with conventional therapy and in 66% of those in the PDL group; this was statistically insignificant. Partial response was observed in an average of 82% of the warts in patients treated with conventional therapy and 87% in the PDL group. Verruca vulgaris responded more readily than verruca plantaris in both treatment groups. The mean number of treatments to achieve success was similar in both groups. CONCLUSION: The PDL is an efficacious form of therapy for verrucae, as is conventional therapy. PDL therapy should be considered among the better established approaches in the treatment of warts, although data from this trial suggest that this approach is probably not superior. Record #40 of 101 ID: CN-00557852 AU: El-Tonsy MH AU: Anbar TE AU: El-Domyati M AU: Barakat M TI: Density of viral particles in pre and post Nd: YAG laser hyperthermia therapy and cryotherapy in plantar warts. SO: International journal of dermatology YR: 1999 VL: 38 NO: 5 PG: 393-8 PM: PUBMED 10369554 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article AD: Department of Dermatology, al-Minya University Hospital, Egypt. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/852/CN00557852/frame.html KY: Adolescent; Cryotherapy; DNA, Viral [genetics]; Hyperthermia, Induced [methods]; In Situ Hybridization; Lasers; Papillomaviridae [genetics] [growth & development]; Skin [metabolism] [pathology]; Time Factors; Treatment Outcome; Warts [therapy] [virology]; Adult; Child; Female; Humans; Male CC: HS-HANDSRCH; SR-SKIN AB: BACKGROUND: Warts often present a difficult treatment problem for clinicians because of the lack of specific antipapillomavirus agents. Plantar warts, in particular, represent a therapeutic challenge. METHODS: Twenty-five patients with plantar warts were treated with Nd:YAG hyperthermia and another 25 were treated with cryotherapy. Biopsies were taken before and after treatment in both groups and were examined for the presence of human papillomavirus deoxyribonucleic acid (HPV DNA) using in situ hybridization (ISH). RESULTS: HPV DNA was detected in 100% of untreated warts and in 96% of cryotreated warts, but was not detected in any of the hyperthermia-treated warts. CONCLUSIONS: HPV is more vulnerable to hyperthermia than to cryotherapy. Record #41 of 101 ID: CN-00157260 AU: Smolle J AU: Prause G AU: Kerl H TI: A double-blind, controlled clinical trial of homeopathy and an analysis of lunar phases and postoperative outcome. SO: Archives of dermatology YR: 1998 VL: 134 NO: 11 PG: 1368-70 PM: PUBMED 9828870 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, University of Graz, Austria. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/260/CN00157260/frame.html KY: Double-Blind Method; Homeopathy; Moon; Postoperative Complications [epidemiology]; Skin Diseases [therapy]; Warts [therapy]; Humans CO: Comment in: Arch Dermatol. 1999 May;135(5):602. PMID: 10328208. CC: HS-HANDSRCH; SR-ANAESTH; SR-CHILD; SR-COMPMED; SR-SKIN AB: OBJECTIVE: To use scientific methods to evaluate 2 claims made by practitioners of alternative medicine. DESIGN: A placebo-controlled, doubleblind study of homeopathy in children with warts, and a cohort study of the influence of lunar phases on postoperative outcome in surgical patients. SETTING: Outpatients of a dermatology department (homeopathy study) and inpatients evaluated at an anesthesiology department (lunar phases). SUBJECTS: Sixty volunteers for the homeopathy study and 14,970 consecutive patients undergoing surgery under general anesthesia for the lunar phase study. INTERVENTIONS: Treatment of children with warts with individually selected homeopathic preparations (homeopathic study); surgical procedures including abdominal, vascular, cardiac, thoracic, plastic, and orthopedic operations and assessment of the lunar phase at the time of operation (lunar phase study). MAIN OUTCOME MEASURES: Reduction of area occupied by warts by at least 50% within 8 weeks; death from any cause within 30 days after surgery. RESULTS: Nine of 30 subjects in the homeopathy group and 7 of 30 subjects in the placebo group experienced at least 50% reduction in area occupied by warts (chi 2 = 0.34; P = .56); the mortality rate was 1.20% in patients operated on during waxing moon and 1.33% in patients operated on during waning moon (chi 2 = 0.49; P = .50). CONCLUSIONS: Statements and methods of alternative medicine--as far as they concern observable clinical phenomena--can be tested by scientific methods. When such tests yield negative results, as in the studies presented herein the particular method or statement should be abandoned. Otherwise one would run the risk of supporting superstition and quackery. Record #42 of 101 ID: CN-00200814 AU: Gupta AK AU: Koren G AU: Shear NH TI: A double-blind, randomized, placebo-controlled trial of eutectic lidocaine/prilocaine cream 5% (EMLA) (R) for analgesia prior to cryotherapy of warts in children and adults SO: Pediatric Dermatology YR: 1998 VL: 15 NO: 2 PG: 129-133 XR: EMBASE 1998126308 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/814/CN00200814/frame.html KY: <De1> Emla --Clinical Trial --Ct/ Emla --Drug Administration --Ad/ <De2> Liquid Nitrogen/ <De3> Verruca Vulgaris --Therapy --Th/ Cryotherapy/ <De4> Topical Anesthesia/ Pain Assessment/ Drug Safety/ Drug Tolerability/ Hand Palm/ Foot Sole/ Erythema --Complication --Co/ Pallor --Complication --Co/ Edema --Co Mplication --Co/ Human/ Male/ Female/ Major Clinical Study/ Randomized Controlled Trial/ Double Blind Procedure/ Controlled Study/ Adolescent/ Child/ Adult/ Topical Drug Administration/ Article/ Priority Journal AB: Liquid nitrogen cryotherapy is an effective treatment modality for verrucae in children. However, sometimes the pain of the procedure is too much for the young child. In such instances the availability of an effective topical anesthetic would be of tremendous benefit. Warts are usually present on hardened skin, that is, the palms, periungual areas, and soles. In a double-blind, randomized, placebo-controlled, single-center, parallel-group trial with one visit, children (6-18 years old) and adults (>18 years old) had 2.5 g of lidocaine/prilocaine cream 5% applied under an occlusive dressing to the wart and a 1 to 2 mm area surrounding it 1 hour prior to liquid nitrogen cryotherapy. In both age groups the warts were subdivided by location-hardened skin areas versus nonhardened skin sites. The topical anesthetic was then removed and cryotherapy applied for 5 to 10 seconds. The pain of cryotherapy was assessed by the patient on a visual analogue scale (VAS) immediately after the cryotherapy and 4 and 8 hours later. There was no statistically significant difference in the pain of cryotherapy experienced following the application of active cream (n = 64) and placebo (n = 64). Exploratory subgroup analysis by wart location showed promising results for lidocaine/prilocaine cream 5% over placebo in children with warts on hardened skin sites (palms and soles). The topical anesthetic was safe and generally well-tolerated. Lidocaine/prilocaine cream 5% may provide some anesthesia in children receiving cryotherapy when the wart is on the palms or soles. Further studies are needed to better understand the site and age specificity of the anesthetic properties of lidocaine/prilocaine cream 5% when used to reduce the pain experienced during cryotherapy of warts. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #43 of 101 ID: CN-00465888 AU: Ahmed I et al TI: Comparison of liquid nitrogen application with spray versus cotton bud in the treatment of common warts of hands and feet Abstract FC13-5 The 7th Congress of the European Academy of Dermatology and Venereology, Nice, 7-11 Ocober 1998. SO: Journal of the European Academy of Dermatology & Venereology YR: 1998 VL: 11 NO: Suppl 2 PG: S150 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/888/CN00465888/frame.html CC: SR-SKIN Record #44 of 101 ID: CN-00256602 AU: Barba A AU: Tessari G AU: Talamini G AU: Chieregato GC TI: Analysis of risk factors for cutaneous warts in renal transplant recipients. SO: Nephron YR: 1997 VL: 77 NO: 4 PG: 422-6 PM: PUBMED 9434064 PT: Clinical Trial; Controlled Clinical Trial; Journal Article AD: Department of Dermatology and Venereal Diseases, University of Verona, Italy. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/602/CN00256602/frame.html KY: Adolescent; Age Factors; Azathioprine [therapeutic use]; Body Mass Index; Cyclosporine [therapeutic use]; Follow-Up Studies; HLA-A Antigens [immunology] [metabolism]; HLA-B Antigens [immunology] [metabolism]; Immunosuppressive Agents [adverse effects] [therapeutic use]; Kidney Transplantation [adverse effects] [immunology]; Prednisolone [therapeutic use]; Risk Factors; Skin Neoplasms [epidemiology]; Warts [epidemiology]; Adult; Aged; Female; Humans; Male; Middle Aged CC: HS-HANDSRCH; SR-ENDOC AB: We have investigated some possible risk factors for cutaneous warts in a consecutive group of renal transplant recipients treated with three different immunosuppressive regimens: prednisolone + azathioprine (PA), prednisolone + azathioprine + cyclosporin (PAC), prednisolone + cyclosporin (PC). Kaplan and Meier analysis showed an earlier onset of warts in the PAC and PC groups than in the PA group (p < 0.0001), which might be related to the different immunosuppressive action of the pharmacological treatments including cyclosporin. Seven patients had skin cancer: 4 of them also had multiple warts on the cancer site. In 2 patients, histological examination demonstrated the neoplastic transformation of a wart. Maintenance posology of azathioprine, cyclosporin and prednisolone may be an important risk factor for cutaneous warts; on the other hand HLA-B mismatch and HLA-A11 seem to have no effect. Record #45 of 101 ID: CN-00187422 AU: Marroquin EA AU: Blanco JA AU: Granados S AU: Caceres A AU: Morales C TI: Clinical trial of Jatropha curcas sap in the treatment of common warts SO: Fitoterapia YR: 1997 VL: 68 NO: 2 PG: 160-162 XR: EMBASE 1997158929 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/422/CN00187422/frame.html KY: Plant Extract --Clinical Trial --Ct/ Plant Extract --Drug Dose --Do/ Plant Extract --Drug Therapy --Dt/ Plant Extract --Pharmacology --Pd/ Liquid Nitrogen/ Placebo/ Verruca Vulgaris --Drug Therapy --Dt/ Antiviral Activity/ Treatment Planning/ Wart Virus/ Immune Response/ Wound Healing/ Human/ Major Clinical Study/ Clinical Trial/ Controlled Study/ Human Tissue/ Human Cell/ Article CC: SR-COMPMED; SR-SKIN AB: The milky sap of J. curcas is used in Mesoamerica for the treatment of different dermatomucosal diseases. With a defined protocol, 147 warts lesions from 30 patients were studied. The sap was applied daily for 15 days and compared with one application of liquid nitrogen and daily applications of a placebo. Experimentally treated lesions behave statistically as those treated with liquid nitrogen but differently from placebo. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #46 of 101 ID: CN-00192862 AU: Varnavides CK AU: Henderson CA AU: Cunliffe WJ TI: Intralesional interferon: Ineffective in common viral warts SO: Journal of Dermatological Treatment YR: 1997 VL: 8 NO: 3 PG: 169-172 XR: EMBASE 1997295964 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/862/CN00192862/frame.html KY: Lymphoblast Interferon --Drug Administration --Ad/ Lymphoblast Interferon -Drug Therapy --Dt/ Alpha Interferon --Clinical Trial --Ct/ Alpha Interferon -- Drug Administration --Ad/ Alpha Interferon --Drug Therapy --Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Verruca Vulgaris --Drug Resistance --Dr/ Verruca Plantaris --Drug Therapy --Dt/ Intralesional Drug Administration/ Human/ Male/ Female/ Clinical Article/ Controlled Study/ Adolescent/ Adult/ Clinical Trial/ Double Blind Procedure/ Article/ Priority Journal CC: HS-HANDSRCH; SR-SKIN AB: We describe a double-blind placebo-controlled trial of human lymphoblastoid interferon alpha, injected intralesionally into common palmar and plantar viral warts, resistant to conventional therapy. Warts had been present for at least 12 months. Subjects who were immunocompromised were excluded. Of 51 patients recruited, 42 completed the trial (19 women and 23 men). There was no significant difference between the responses in the two groups with total clearance of injected warts in 61% of the interferon-treated group and 63% of the placebo-treated group. The type and duration of the wart, and sex and age of the patient did not influence the response rate. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #47 of 101 ID: CN-00187943 AU: Karabulut AA AU: Sahin S AU: Ekşioglu M TI: Is cimetidine effective for nongenital warts: a double-blind, placebocontrolled study. SO: Archives of dermatology YR: 1997 VL: 133 NO: 4 PG: 533-4 PM: PUBMED 9126017 XR: EMBASE 1997124196 PT: Clinical Trial; Letter; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/943/CN00187943/frame.html KY: Adjuvants, Immunologic [therapeutic use]; Adolescent; Cimetidine [therapeutic use]; Double-Blind Method; Skin Diseases [drug therapy]; Warts [drug therapy]; Adult; Child; Female; Humans; Male CC: HS-HANDSRCH Record #48 of 101 ID: CN-00466073 AU: Karabulut AA AU: Sahin S AU: Eksioglu M TI: Is cimetidine effective for nongenital warts: a double-blind, placebocontrolled study letter SO: Archives of Dermatology YR: 1997 VL: 133 NO: 4 PG: 533-4 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/073/CN00466073/frame.html CC: SR-SKIN Record #49 of 101 ID: CN-00171530 AU: Larsen PO AU: Laurberg G TI: Cryotherapy of viral warts. SO: Journal of Dermatological Treatment. YR: 1996 VL: 7 NO: 1 PG: 29-31 XR: EMBASE 1996130454 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/530/CN00171530/frame.html KY: medical: cryotherapy*/ viral skin disease*/ therapy/ verruca vulgaris*/ therapy/ prospective study/ disease duration/ freezing/ human/ male/ female/ major clinical study/ adolescent/ aged/ child/ preschool child/ school child/ adult/ clinical trial/ randomized controlled trial/ multicenter study/ priority journal/ article. drug: liquid nitrogen*. CC: HS-HANDSRCH; SR-SKIN AB: A total of 144 patients with at least one viral hand wart were treated with liquid nitrogen cryotherapy in an open, multicentre, prospective study. The aim of the study was to determine the optimum interval between cryotherapy treatments. An effort was also made to determine whether the cure rate was related to the age of the patient, the duration of the disease and/or the total number of warts. The patients were grouped according to age, duration of disease and number of warts, and an index finger wart not previously treated with cryotherapy was the basis for randomization of the patients for treatment at 2-, 3- or 4-week intervals until cure was achieved or a maximum of six treatments had been given. Cure rates were evaluated 3 and 6 months after the initiation of treatment. The cure rates of the index wart were 71% and 65% evaluated after 3 and 6 months, respectively. After 6 months, cure rates of 63%, 70% and 63% were seen for index warts treated with cryotherapy at 2-, 3- and 4- week intervals, respectively. If the index wart was not cured after four or five freezings, further cryotherapy was unlikely to be successful. For the wart disease of the patients in general, the cure rates were 22% and 29% after 3 and 6 months. The best cure rates were found among young patients with few warts of short duration. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #50 of 101 ID: CN-00192056 AU: Kubeyinje EP TI: Evaluation of the efficacy and safety of 0.05% tretinoin cream in the treatment of plane warts in Arab children SO: Journal of Dermatological Treatment YR: 1996 VL: 7 NO: 1 PG: 21-22 XR: EMBASE 1996130452 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/056/CN00192056/frame.html KY: Retinoic Acid --Drug Therapy --Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Treatment Outcome/ Drug Efficacy/ Drug Safety/ Saudi Arabia/ Human/ Male/ Female/ Clinical Article/ Controlled Study/ Adolescent/ Child/ Topical Drug Administration/ Priority Journal/ Article CC: SR-SKIN AB: Introduction: Topicalvtretinoin (Retin-A), although currently recommended for the treatment of acne, has also been reported to be of benefit in a widerange of skin diseases including plane warts, ichthyosis, lichen planus and photodamaged skin. The objective of this study was to evaluate the efficacy and safety of topical tretinoin (0.05% cream) in the treatment of plane warts in Arab children. Methods: A group of 25 children with plane warts treated with 0.05% topical tretinoin cream (applied once daily for 6 weeks) were compared with a control group of 25 untreated children. Patients were reviewed weekly and a final assessment was done at 12 weeks. Results: After 12 weeks, clearance of warts was observed in 84.6% of the treated group as compared with 32% of the control group. The difference was statistically significant (P < 0.01). The drug was well tolerated. Even though 42.3% of the treated group had some redness and peeling, only one patient discontinued treatment. Conclusion: Topical 0.05% tretinoin cream appears to be an effective and safe treatment for children with plane warts. This was a pilot study that needs confirmation by a large doubleblind, placebo-controlled trial. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #51 of 101 ID: CN-00466267 AU: S·enz MC TI: Oral cimetidine in the treatment of common warts. (Spanish) OT: Tratamiento de las verrugas vulgares con cimetidina. (Spanish) SO: Actas Dermo-Sifiliograficas YR: 1996 VL: 87 PG: 123-7 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/267/CN00466267/frame.html CC: SR-SKIN Record #52 of 101 ID: CN-00662812 AU: Saenz de Santa Maria MªC AU: Saez-Benito A AU: Gilaberte Y TI: Therapy with cimetidine for verruca vulgaris OT: Tratamiento de las verrugas vulgares con cimetidina. SO: Actas Dermo-Sifiliogr·ficas YR: 1996 VL: 87 PG: 123-7 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/812/CN00662812/frame.html CC: HS-HANDSRCH Record #53 of 101 ID: CN-00187367 AU: Larsen PO TI: Contact immunotherapy of resistant warts with diphenylcyclopropenone SO: Journal of Dermatological Treatment YR: 1995 VL: 6 NO: 2 PG: 81-83 XR: EMBASE 1995218195 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/367/CN00187367/frame.html KY: Diphencyprone --Adverse Drug Reaction --Ae/ Diphencyprone --Drug Therapy -Dt/ Petrolatum --Pharmaceutics --Pr/ Immunotherapy/ Verruca Vulgaris --Drug Therapy --Dt/ Eczema --Side Effect --Si/ Questionnaire/ Retrospective Study/ Human/ Male/ Female/ Major Clinical Study/ Topical Drug Administration/ Priority Journal/ Article AB: Immunotherapy with dinitrochlorobenzene (DNCB) or diphenylcyclopropenone (DCP) as contact allergens has been used in the treatment of warts of long duration that are resistant to simple treatment. In a prospective, open study, 241 patients with treatment-resistant warts were sensitized with 1% DCP in petrolatum. The warts were then treated every third week with 0.5%, 1% or 5% DCP in petrolatum until all wart tissue had disappeared and the normal surface of the skin was restored, or for up to 18 months. A follow-up questionnaire was mailed to 100 randomly selected patients an average of 22 months after initiation of the treatment. Of the 241 patients, 213 were evaluated, and of these 13 had plane warts, 81 had multiple warts on the hands and feet and 119 had mosaic warts on the feet. The cure rate was 85% for those who completed the treatment before 18 months of treatment. Treatment duration was an average of 5.8 months, and patients who were cured received an average of 7.8 treatments. Of the 100 patients sent the questionnaire, 81 responded. There was no recurrence of 78-99% of the warts originally cured (95% confidence interval). The appearance of new warts in some patients indicated that the wart disease had been eliminated in only 58-89% of the patients (95% confidence interval). Of the 213 patients, 22% experienced side-effects of the treatment, mainly bullous eczema at the treatment site or eczema elsewhere. Only three patients stopped treatment because of the side-effects. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #54 of 101 ID: CN-00113071 AU: Bourke JF AU: Berth-Jones J AU: Hutchinson PE TI: Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. SO: The British journal of dermatology YR: 1995 VL: 132 NO: 3 PG: 433-6 PM: PUBMED 7718461 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Leicester Royal Infirmary, U.K. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/071/CN00113071/frame.html KY: Adolescent; Blister [etiology]; Cryotherapy [adverse effects]; Dermatology; Time Factors; Treatment Outcome; Warts [therapy]; Workload; Adult; Child; Child, Preschool; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: We studied the efficacy, and time to clearance, of more frequent cryotherapy of viral warts, by randomizing 225 patients to receive treatment at 1-, 2- or 3weekly intervals. The mean times to clearance of warts in each group were 5.5, 9.5 and 15 weeks in the weekly, 2-weekly and 3-weekly groups, respectively (P < 0.01). Cure rates after 3 months correlated with frequency of treatment (P < 0.05). After 3 months, 43% (66% of non-defaulters) had cleared in the group treated weekly, 37% (47%) of the group treated every 2 weeks, and 26% (30%) of those treated every 3 weeks. The mean numbers of treatments needed to achieve clearance were similar in each group (5.5, 4.75 and 5 treatments). After 12 treatments, cure rates were similar for all three groups: 43% for the weeklytreated group (3 months), 48% for the 2-weekly group (6 months), and 44% for the 3-weekly group (9 months). Percentage cure is related to the number of treatments received, and independent of the interval between treatments. A more rapid cure may, therefore, be achieved by more frequent treatment. Record #55 of 101 ID: CN-00114720 AU: Humphreys F AU: Spiro J TI: The effects of topical indomethacin and clobetasol propionate on postcryotherapy inflammation. SO: The British journal of dermatology YR: 1995 VL: 132 NO: 5 PG: 762-5 PM: PUBMED 7772482 XR: EMBASE 1995146841 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Royal Infirmary, Edinburgh, U.K. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/720/CN00114720/frame.html KY: Administration, Topical; Adolescent; Clobetasol [administration & dosage]; Cryotherapy; Dermatitis [pathology] [prevention & control]; Double-Blind Method; Edema [prevention & control]; Erythema [prevention & control]; Indomethacin [administration & dosage]; Postoperative Complications [pathology] [prevention & control]; Skinfold Thickness; Warts [therapy]; Adult; Child; Female; Humans; Male; Middle Aged CC: SR-ANAESTH; SR-ENDOC; SR-SKIN AB: The effects of topical indomethacin and clobetasol propionate on erythema and oedema following low-dose cryotherapy to normal skin were examined using a single-blind technique. Both agents significantly reduced erythema, but neither had a significant effect on oedema. A further, controlled, double-blind study comparing topical indomethacin and inert gel base was performed after cryotherapy to hand warts. In this study, topical indomethacin had no significant effect on post-cryotherapy oedema, erythema, pain or blister formation 48 and 96 h after treatment. Both potent topical steroids and cyclooxygenase inhibitors reduce erythema after low-dose cryotherapy. In clinical practice, there is no evidence that topical indomethacin significantly inhibits the inflammatory response to cryotherapy. Record #56 of 101 ID: CN-00173277 AU: Schreiner T AU: Brzoska J AU: Fierlbeck G TI: Topical application of tretinoin, interferon beta and their combination in the treatment of flat warts. SO: Journal of Dermatological Treatment. YR: 1995 VL: 6 NO: 1 PG: 17-19 XR: EMBASE 1995125043 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/277/CN00173277/frame.html KY: medical: verruca vulgaris*/ drug therapy/ wart virus/ remission/ drug efficacy/ drug potentiation/ human/ male/ female/ major clinical study/ adolescent/ infant/ child/ preschool child/ school child/ adult/ topical drug administration/ clinical trial/ randomized controlled trial/ priority journal/ article. drug: retinoic acid*/ clinical trial, drug administration, drug combination, drug comparison, drug therapy/ beta interferon*/ clinical trial, drug administration, drug combination, drug comparison, drug therapy/ anti acne agent/ clinical trial, drug administration, drug combination, drug comparison, drug therapy/ antivirus agent/ clinical trial, drug administration, drug combination, drug comparison, drug therapy. CC: SR-SKIN AB: Flat warts, mainly caused by human papillomavirus types 3 and 10, have a high rate of spontaneous remission. Those warts that do not disappear by themselves can be very difficult to treat. In our study we compared the efficacy of topical tretinoin, topical interferon beta and the combination of both substances in the treatment of flat warts. The combination of both substances proved to be considerably more effective than either alone. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #57 of 101 ID: CN-00183223 AU: Artese O AU: Cazzato C AU: Cucchiarelli S AU: Iezzi D AU: Palazzi P AU: Ametetti M TI: Controlled study: Medical therapy (5-fluorouracil, salicylic acid) vs physical therapy (DTC) of warts. <ORIGINAL> STUDIO CONTROLLATO TERAPIA MEDICA (5-FLUOROURACILE, AC. SALICILICO) VERSO TERAPIA FISICA (DTC) DELLE VERRUCHE VOLGARI SO: DERMATOL. CLIN. YR: 1994 VL: 14 NO: 1 PG: 55-59 XR: EMBASE 1994194658 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/223/CN00183223/frame.html KY: Fluorouracil --Drug Therapy --Dt/ Salicylic Acid --Drug Therapy --Dt/ Verruca Vulgaris --Therapy --Th/ Verruca Vulgaris --Drug Therapy --Dt/ Patient Compliance/ Drug Efficacy/ Human/ Controlled Study/ Major Clinical Study/ Clinical Trial/ Male/ Female/ Child/ Adult/ Topical Drug Administration/ Article AB: We studied 300 patients affected with periungueal, palmar or plantar warts. They were chosen at random and divided into two groups each consisting of 150 patients. The first group was treated with diathermocoagulation, while the second group was treated medically with topical 5-fluorouracil and salicylic acid (respecting the standardized criteria used in all patients). Control after 75 days showed that the medical therapy was more effective with only 23 cases of relapse, while with physical therapy 51 cases of relapse were present. It was also noted that in patients treated with physical therapy, the higher number of relapses were present after 31 days, while in those patients treated medically the higher number of relapses were observed only after 75 days. The only problem with medical therapy was the lack of compliance by the patient (six patients left the study) but, seen the almost complete absence of side affects and in particular its effectiveness, the authors suggest such therapy as an alternative, particularly in pediatric patients. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #58 of 101 ID: CN-00103432 AU: Yazar S AU: Başaran E TI: Efficacy of silver nitrate pencils in the treatment of common warts. SO: The Journal of dermatology YR: 1994 VL: 21 NO: 5 PG: 329-33 PM: PUBMED 8051319 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Akdeniz University, Faculty of Medicine, Department of Dermatology, Antalya, Turkey. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/432/CN00103432/frame.html KY: Administration, Topical; Adolescent; Silver Nitrate [administration & dosage]; Warts [drug therapy]; Adult; Child; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: Common warts are an important issue, especially in children and young adults. The methods proposed for common wart treatment are painful, destructive, and require special experience and devices. The chemical cauterization effect of silver nitrate on warts is noted in the classical pharmaceutical textbooks. In order to test this effect for this purpose, a placebo controlled clinical study was performed on 70 patients. On 35 randomly selected patients, a silver nitrate stick was used, and, on the other 35 patients, black ink was used. At the end of this study, of the patients treated with the silver nitrate stick, 15 (43%) were completely healed, 9 (26%) were partially healed, and 11 (31%) were not healed. Of the patients treated with black ink, 4 (11%) were completely healed, 5 (14%) were partially healed, and 26 (74%) patients were not affected. Thus the silver nitrate stick affected the warts of 24 (69%) patients. Therefore, this method appears to be an effective, economic, and easily applicable treatment for common warts. Record #59 of 101 ID: CN-00098896 AU: Vesterager L AU: Petersen KP AU: Nielsen R AU: Niordson AM AU: Gammeltoft M AU: Graudal C AU: Stahl D TI: EMLA-induced analgesia inferior to lignocaine infiltration in curettage of common warts--a randomized study. SO: Dermatology (Basel, Switzerland) YR: 1994 VL: 188 NO: 1 PG: 32-5 PM: PUBMED 8305754 PT: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial AD: Private Dermatological Clinics in Lyngby, Denmark. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/896/CN00098896/frame.html KY: Adolescent; Anesthetics, Local; Curettage; Drug Combinations; Injections; Lidocaine [administration & dosage]; Ointments; Pain Measurement; Prilocaine [administration & dosage]; Warts [surgery]; Adult; Child; Female; Humans; Male; Middle Aged CC: SR-ANAESTH; SR-SKIN; SR-SYMPT AB: The analgesic effect of topical application of EMLA cream for the curettage verrucae vulgaris was compared to local infiltration with lignocaine in 89 patients. The main purpose of this randomized study was to evaluate the patients' overall impression of the treatment. All patients anaesthetized by lignocaine infiltration reported it as 'an acceptable procedure' compared to only 71% of the patients treated with EMLA. It cannot be recommended to use EMLA cream as local anaesthetic for curettage of verrucae vulgaris, presumably because the highly keratotic nature of the common warts does not allow sufficient penetration of epicutaneously applied EMLA. Record #60 of 101 ID: CN-00174020 AU: Vesterager L AU: Petersen KP AU: Nielsen R AU: Niordson AM AU: Gammeltoft M AU: Graudal C AU: Stahl D TI: EMLAregistered trade mark-induced analgesia inferior to lignocaine infiltration in curettage of common warts - A randomized study. SO: DERMATOLOGY YR: 1994 VL: 188 NO: 1 PG: 32-35 XR: EMBASE 1994013708 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/020/CN00174020/frame.html KY: medical: analgesia*/ pain*/ drug therapy/ verruca vulgaris*/ surgery/ patient satisfaction/ skin surgery/ drug penetration/ pain assessment/ human/ male/ female/ major clinical study/ adolescent/ child/ school child/ adult/ topical drug administration/ clinical trial/ randomized controlled trial/ multicenter study/ priority journal/ article. drug: emla*/ clinical trial, drug comparison, drug therapy, pharmacokinetics/ lidocaine*/ clinical trial, drug comparison, drug therapy/ local anesthetic agent/ clinical trial, drug therapy/ cream. AB: The analgesic effect of topical application of EMLA cream for the curettage verrucae vulgaris was compared to local infiltration with lignocaine in 89 patients. The main purpose of this randomized study was to evaluate the patients' overall impression of the treatment. All patients anaesthetized by lignocaine infiltration reported it as 'an acceptable procedure' compared to only 71% of the patients treated with EMLA. It cannot be recommended to use EMLA cream as local anaesthetic for curettage of verrucae vulgaris, presumably because the highly keratotic nature of the common warts does not allow sufficient penetration of epicutaneously applied EMLA. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #61 of 101 ID: CN-00187738 AU: Dwyer CM AU: Cuddihy A AU: Chapman RS AU: Gillen G TI: Failure of clobetasol propionate to relieve symptoms after cryotherapy of hand warts SO: J DERMATOL TREAT YR: 1994 VL: 5 NO: 1 PG: 11 XR: EMBASE 1994116475 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/738/CN00187738/frame.html KY: Clobetasol Propionate --Drug Therapy --Dt/ Corticosteroid --Clinical Trial -Ct/ Corticosteroid --Drug Therapy --Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Verruca Vulgaris --Therapy --Th/ Cryotherapy/ Hand/ Pain/ Blister/ Disease Severity/ Symptom/ Human/ Clinical Article/ Controlled Study/ Topical Drug Administration/ Clinical Trial/ Double Blind Procedure/ Priority Journal/ Article CC: HS-HANDSRCH; SR-SKIN AB: A study was performed to assess the value of a topical corticosteroid after cryotherapy of hand warts. The study group comprised 25 patients who had a pair of warts suitable for comparison. The warts were treated with liquid nitrogen cryotherapy using a standardized method. Clobetasol propionate was applied to one of each pair of warts and placebo to the other under double-blind conditions. Using a visual analogue scale the patients recorded the severity of pain, duration of pain and the severity of blistering in each lesion. Analysis of the results showed no significant difference between lesions treated with corticosteroid and those treated with placebo. We conclude that a single application of clobetasol propionate is ineffective in relieving symptoms after cryotherapy of hand warts. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #62 of 101 ID: CN-00318667 AU: Bourke JF,Berth Jones J TI: Is frequent cryotherapy more effective in the treatment of common viral warts? SO: British Journal of Dermatology YR: 1994 VL: 131 NO: Suppl 44 PG: 46 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/667/CN00318667/frame.html CC: SR-SKIN Record #63 of 101 ID: CN-00110600 AU: Berth-Jones J AU: Bourke J AU: Eglitis H AU: Harper C AU: Kirk P AU: Pavord S AU: Rajapakse R AU: Weston P AU: Wiggins T AU: Hutchinson PE TI: Value of a second freeze-thaw cycle in cryotherapy of common warts. SO: The British journal of dermatology YR: 1994 VL: 131 NO: 6 PG: 883-6 PM: PUBMED 7857844 XR: EMBASE 1994376189 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Leicester Royal Infirmary, U.K. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/600/CN00110600/frame.html KY: Cryotherapy [methods]; Foot Dermatoses [therapy]; Hand Dermatoses [therapy]; Warts [therapy]; Adult; Female; Humans; Male CC: SR-SKIN AB: A study of open, randomized, parallel-group design was performed to investigate the impact of a second freeze-thaw cycle on the cure rate, at 3 months, from cryotherapy of common warts on the hands and feet. Cryotherapy was performed at 3-week intervals, and subjects were randomized to receive either one or two freeze-thaw cycles. In addition, all subjects used keratolytic wart paints throughout the study, and plantar warts were pared prior to freezing. Three hundred subjects were recruited. At 3 months, 124 were cured, 83 were not cured, and 93 had defaulted. Among those who did not default the cure rate was 57% from the single freeze technique, and 62% from the double freeze technique, a difference of 5% (P = 0.53, 95% CI-8.1-18.6). Separate analyses for subjects with warts on the hands and on the feet demonstrated no effect of double freezing on hand warts. In contrast, for plantar warts, the cure rate was 41% from single freezing and 65% for double freezing, a difference of 24% (P = 0.04, 95% CI 2.9-44.4). The use of a double freeze-thaw cycle confers little or no advantage over a single freeze in the treatment of hand warts, but may be considerably more effective for plantar warts. Record #64 of 101 ID: CN-00085569 AU: Stern P AU: Levine N TI: Controlled localized heat therapy in cutaneous warts. SO: Archives of dermatology YR: 1992 VL: 128 NO: 7 PG: 945-8 PM: PUBMED 1626962 PT: Clinical Trial; Controlled Clinical Trial; Journal Article AD: Section of Dermatology, University of Arizona Health Sciences Center, Tucson 85724. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/569/CN00085569/frame.html KY: Electric Stimulation Therapy [methods]; Hand Dermatoses [therapy]; Hot Temperature [therapeutic use]; Warts [therapy]; Adult; Female; Humans CC: HS-HANDSRCH; SR-COMPMED; SR-SKIN AB: BACKGROUND--Controlled localized heating as a method of superficial tissue destruction has been used in veterinary medicine for the treatment of benign and malignant tumors. The rationale for its use is that the diseased tissue being treated is more sensitive to the effects of heating than is normal tissue. This technology was applied to the treatment of common hand warts in a placebocontrolled study. OBSERVATIONS--Twenty-nine warts were treated one to four times (median, two times) at 50 degrees C for 30 to 60 seconds. Twenty-five (86%) of 29 treated verrucae regressed completely while seven (41%) of 17 control warts resolved during the course of the study. No wart that regressed regrew during the follow-up period (mean, 15.6 weeks). CONCLUSIONS--Controlled localized heating can cause the regression of hand warts. The 86% regression rate compares favorably with other wart treatment modalities. The mechanism of action and the effect of heat on these virally induced tumors is not known but may involve direct antiviral effects, physical destruction of the tumor, or the promotion of an inflammatory response that ultimately eradicates the lesion. Record #65 of 101 ID: CN-00084564 AU: Labrecque M AU: Audet D AU: Latulippe LG AU: Drouin J TI: Homeopathic treatment of plantar warts. SO: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne YR: 1992 VL: 146 NO: 10 PG: 1749-53 PM: PUBMED 1596811 PT: Clinical Trial; Journal Article; Randomized Controlled Trial AD: Department of Family Medicine, UniversitÈ Laval, Sainte-Foy, Que. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/564/CN00084564/frame.html KY: Adolescent; Double-Blind Method; Foot Diseases [therapy]; Homeopathy; Placebos; Treatment Outcome; Warts [therapy]; Adult; Child; Female; Humans; Male; Middle Aged CO: Comment in: CMAJ. 1992 May 15;146(10):1719-20, 1723-5. PMID: 1596807. Comment in: CMAJ. 1992 Nov 15;147(10):1407-8; author reply 1408-9. PMID: 1308761. Comment in: CMAJ. 1992 Nov 15;147(10):1407; author reply 1408-9. PMID: 1423066. CC: SR-CHILD; SR-COMPMED; SR-SKIN AB: OBJECTIVE: To evaluate the efficacy of a homeopathic treatment of plantar warts. DESIGN: Randomized double-blind placebo-controlled trial. SETTING: Hospital-based family medicine unit. PATIENTS: Patients were recruited from the unit, through advertisements in the local media and through personal contacts with colleagues. Of the 853 people screened between December 1987 and January 1989, 174 met the eligibility criteria (age 6 to 59 years and presence of one or more plantar warts untreated during the previous 3 months) and agreed to participate; 162 (93%) completed the 18-week follow-up. INTERVENTIONS: The 6week homeopathic treatment consisted of thuya 30 "centÈsimal hahnemannien" (CH) (one tube containing 200 pellets weekly), antimonium crudum 7 CH (5 pellets daily) and nitricum acidum 7 CH (one tube containing 200 pellets daily). The placebo pellets were identical to the treatment pellets in appearance and taste. MAIN OUTCOME MEASURE: The proportion of healed patients; a patient was considered healed if all of the warts had disappeared. MAIN RESULTS: The rates of healing at 6, 12 and 18 weeks were 4.8%, 13.4% and 20.0% respectively in the homeopathic treatment group and 4.6%, 13.1% and 24.4% in the placebo treatment group. CONCLUSION: The homeopathic treatment was no more effective than the placebo treatment of plantar warts. Record #66 of 101 ID: CN-00466178 AU: Perez Alfonzo R AU: Weiss E AU: Piquero Martin J TI: Hypertonic saline solution vs intralesional bleomycin in the treatment of common warts SO: Dermatologia Venezolana YR: 1992 VL: 30 PG: 176-178 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/178/CN00466178/frame.html CC: SR-SKIN Record #67 of 101 ID: CN-00087265 AU: Berth-Jones J AU: Hutchinson PE TI: Modern treatment of warts: cure rates at 3 and 6 months. SO: The British journal of dermatology YR: 1992 VL: 127 NO: 3 PG: 262-5 PM: PUBMED 1382540 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial AD: Department of Dermatology, Leicester Royal Infirmary, U.K. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/265/CN00087265/frame.html KY: Adolescent; Combined Modality Therapy; Cryosurgery [methods]; Drug Therapy, Combination; Foot Dermatoses [therapy]; Hand Dermatoses [therapy]; Inosine Pranobex [therapeutic use]; Random Allocation; Time Factors; Treatment Outcome; Warts [therapy]; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Male; Middle Aged CC: SR-SKIN AB: Four-hundred consecutive referrals with viral warts of the hands and/or feet were investigated to determine the cure rate from a combination of cryotherapy, keratolytic wart paint and paring. For treatment failures after 3 months, the value of continuing cryotherapy and of additional treatment with the immunomodulator inosine pranobex were assessed. Subjects were treated for 3 months with wart paint and cryotherapy and were randomized to receive, or not, paring in addition. Those who did not respond by 3 months were randomized to receive, or not, 3 months further cryotherapy, and to receive inosine pranobex 60 mg/kg/day for 1 week each month, or matching placebo. Fifty-two per cent of subjects were cured by 3 months. The chance of cure was inversely related both to the length of history and to the diameter of the largest wart. Paring improved the cure rate for plantar warts but not for hand warts. During the second 3 months the cure rate fell to 41%. Neither cryotherapy nor inosine pranobex significantly improved this response. Record #68 of 101 ID: CN-00194864 AU: Erkens AMJL AU: Kuijpers RJAM AU: Knottnerus JA TI: Treatment of verrucae vulgares in general practice - a randomized controlled trial on the effectiveness of liquid nitrogen and the Histofreezer SO: J DERMATOL TREAT YR: 1992 VL: 3 NO: 4 PG: 193-196 XR: EMBASE 1993020257 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/864/CN00194864/frame.html KY: Liquid Nitrogen/ Cryotherapy/ Verruca Vulgaris --Therapy --Th/ General Practice/ Human/ Male/ Female/ Major Clinical Study/ Controlled Study/ Adolescent/ Infant/ Child/ Preschool Child/ School Child/ Adult/ Article CC: HS-HANDSRCH; SR-CHILD; SR-SKIN AB: In general practice, treating verrucae vulgares with liquid nitrogen has some practical drawbacks. Therefore, in a randomized controlled trial this therapy was compared with a new and easy-to-use form of cryotherapy, the Histofreezer. The warts were treated monthly with liquid nitrogen and twice a month with the Histofreezer. Included in the study were 93 patients with 191 verrucae of whom 17 (38 verrucae) did not comply fully during the study. With the liquid nitrogen treatment 66% of warts were cured, and 49% with the Histofreezer treatment (P= 0.08). All verrucae disappeared in 67% of the patients treated with liquid nitrogen, and in 35% of those treated with the Histofreezer (P= 0.01). For dorsal, non-protuberant and small verrucae, and in patients younger than 21 years, there were almost no differences. In conclusion, the overall results of treatment with liquid nitrogen were better. However, in certain cases, e.g. in young children, the Histofreezer might be attractive. Further study in this direction is recommended. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #69 of 101 ID: CN-00181951 AU: Erkens AMJL AU: Kuijpers RJAM AU: Knottnerus JA TI: A randomized trial on the effectiveness of liquid nitrogen and Histofreezer in the treatment of hand wars SO: NED. TIJDSCHR. GENEESKD. YR: 1991 VL: 135 NO: 5 PG: 171-174 XR: EMBASE 1991067419 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/951/CN00181951/frame.html KY: Liquid Nitrogen --Drug Toxicity --To/ Verruca Vulgaris --Therapy --Th/ Cryotherapy/ Randomization/ Clinical Trial/ Human/ Male/ Female/ Major Clinical Study/ Adolescent/ Infant/ Child/ Adult/ Article AB: Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #70 of 101 ID: CN-00073814 AU: Erkens AM AU: Kuijpers RJ AU: Knottnerus JA TI: [An end to office hours for warts? A randomized study of the effectiveness of liquid nitrogen and of the Histofreezer] OT: Het einde van het wrattenspreekuur? Een gerandomiseerd onderzoek naar de effectiviteit van vloeibare stikstof en van de Histofreezer. SO: Nederlands tijdschrift voor geneeskunde YR: 1991 VL: 135 NO: 5 PG: 171-4 PM: PUBMED 2002864 PT: Clinical Trial; Comparative Study; English Abstract; Journal Article; Randomized Controlled Trial AD: Rijksuniversiteit Limburg, vakgroep Huisartsgeneeskunde, Maastricht. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/814/CN00073814/frame.html KY: Adolescent; Clinical Protocols; Cryosurgery [methods]; Nitrogen [administration & dosage]; Prognosis; Warts [surgery] [therapy]; Adult; Child; Female; Humans; Male AB: OBJECTIVE. Comparison of the effectiveness of liquid nitrogen and of cryotherapy by means of the Histofreezer in the treatment of hand warts. DESIGN. Randomized therapeutic trial. SETTING. Six general practices in Limburg, The Netherlands. PATIENTS AND METHODS. Of the patients 43 (with 83 warts) were treated with nitrogen (if necessary twice) and 50 (with 108 warts) with the Histofreezer (if necessary 4 times), with a final control visit after 2.5 months. After a training session, the general practitioners performed the treatments and the observations. In these groups, 7 patients (with 18 warts) and 10 patients (with 20 warts) respectively did not fully comply with the protocol. At the start the number of warts per patient, their size, protruberance and localization were registered. Statistical analysis was performed by chi 2 test (unpaired case) in an intention to treat approach and of compliers only. OUTCOME MEASURES. Disappearance of warts, pain (on a 3-point scale), wounds, depigmentation. Non-compliers were asked by telephone if their warts had been cured. RESULTS. Of all patients 58% was cured by liquid nitrogen and 28% by Histofreezer (p = 0.01). Among the compliers these percentages were 67% and 35% of the patients (p = 0.01) and 66% and 49% of the warts (p = 0.08). The treatments were about equally effective in dorsal non protuberant and small (less than 5 mm) warts, and among young (less than 20 years) patients. CONCLUSION. The overall results of liquid nitrogen were better. The Histofreezer seems to be attractive in certain cases (e.g. children), but this should be the subject of further study. Record #71 of 101 ID: CN-00509709 AU: Oram Y AU: Karaaslan F AU: Artuz F. AU: Alli N TI: Interferon alpha-2 treatment for verruca vulgaris SO: Deri Hastalikrari Ve Frengi Assivi YR: 1991 VL: 25 NO: 3 PG: 193-9 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/709/CN00509709/frame.html CC: SR-SKIN Record #72 of 101 ID: CN-00187460 AU: Benton EC AU: Nolan MW AU: Kemmett D AU: Cubie HA TI: Trial of inosine pranobex in the management of cutaneous viral warts SO: J DERMATOL TREAT YR: 1991 VL: 1 NO: 6 PG: 295-297 XR: EMBASE 1991180518 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/460/CN00187460/frame.html KY: Methisoprinol --Adverse Drug Reaction --Ae/ Methisoprinol --Drug Combination --Cb/ Methisoprinol --Drug Therapy --Dt/ Placebo/ Liquid Nitrogen --Drug Therapy --Dt/ Salicylic Acid --Drug Administration --Ad/ Salicylic Acid --Drug Therapy -Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Drug Efficacy/ Wart Virus/ Cryotherapy/ Lymphocyte Proliferation/ Enzyme Linked Immunosorbent Assay/ Side Effect/ Double Blind Procedure/ Human/ Male/ Female/ Major Clinical Study/ Controlled Study/ Adolescent/ School Child/ Adult/ Oral Drug Administration/ Topical Drug Administration/ Article CC: HS-HANDSRCH; SR-SKIN AB: Fifty patients with cutaneous mosaic warts resistant to standard therapy took part in a double-blind, placebo-controlled study to assess the efficacy of inosine pranobex used as an adjunct to standard topical treatments. No statistically significant difference was found in cure rates between the active (37.5%) and placebo treatments (34.6%) at 6 months, nor was there any relationship between clinical response and either antibody production or in vitro assay of lymphocyte proliferative activity against human papilloma virus (HPV) type 2 in either group. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #73 of 101 ID: CN-00185871 AU: Lee SW AU: Houh D AU: Kim HO AU: Kim CW AU: Kim TY TI: Clinical trials of interferon-gamma in treating warts SO: ANN DERMATOL YR: 1990 VL: 2 NO: 2 PG: 77-82 XR: EMBASE 1991040294 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/871/CN00185871/frame.html KY: Gamma Interferon --Drug Therapy --Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Human/ Male/ Female/ Major Clinical Study/ Controlled Study/ Adolescent/ Child/ Adult/ Article CC: SR-SKIN AB: This study was performed to investigate the clinical efficacy of intralesional recombinant interferon-gamma (IFN-gamma) in the treatments of warts, using a placebo comparison. Warts of each groups were injected with INFgamma containing 5 x 106 IU/ml (high dose), 1 x 106 IU/ml (low dose) or distilled water for injection as placebo, respectively, twice weekly for three weeks. The final therapeutic efficacy was determined on the fourth week after the beginning of therapy. Among the 74 patients with periungual warts, plantar warts, or warts of other sites, complete clearing of the treated warts at week four occurred in 56% of the 36 patients receiving the dose IFN-gamma compared to 30% of the 53 receiving the low dose IFN-gamma and 17% of the 36 receiving the placebo. Marked improvement showing 75% or greater regression of wart lesions was noted as 89% of patients receiving the high dose INF, compared with 55% receiving the low dose IFN and 50% receiving the placebo. The group of patients with warts of other sites showed the best response. The group receiving the high dose IFN experienced some adverse effects more frequently or more severely than the group receiving low dose IFN. However, the effects were relatively tolerable to the patients. Therefore, intralesional injection of the high dose IFN-gamma may be more useful in treating warts than a low dose IFN-gamma. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #74 of 101 ID: CN-00065792 AU: Spanos NP AU: Williams V AU: Gwynn MI TI: Effects of hypnotic, placebo, and salicylic acid treatments on wart regression. SO: Psychosomatic medicine YR: 1990 VL: 52 NO: 1 PG: 109-14 PM: PUBMED 2305019 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't AD: Department of Psychology, Carleton University, Ottawa, Canada. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/792/CN00065792/frame.html KY: Administration, Topical; Adolescent; Hypnosis; Salicylic Acid; Salicylic Acids [administration & dosage]; Suggestion; Warts [psychology] [therapy]; Adult; Female; Humans; Male CC: SR-BEHAVMED; SR-COMPMED; SR-SKIN AB: Subjects with warts on their hands and/or feet were randomly assigned to a hypnotic suggestion, topical salicylic acid, placebo, or no treatment control condition. Subjects in the three treated groups developed equivalent expectations of treatment success. Nevertheless, at the six-week follow-up interval only the hypnotic subjects had lost significantly more warts than the no treatment controls. Theoretical implications are discussed. Record #75 of 101 ID: CN-00692664 AU: Chattopadhyay SP AU: Das PK TI: Evaluation of vinca rosea for the treatment of warts SO: Indian Journal of Dermatology, Venerology and Leprology YR: 1990 VL: 56 PG: 107-8 PB: Indian Association of Dermatologists, Venereologists and Leprologists CY: India DE: CCT AD: Department of Dermatology, AFMC and Command Hospital, Pune 411 010, India US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/664/CN00692664/frame.html CC: HS-HANDSRCH AB: Nineteen cases of warts of various types (flat 3, verruca vulgaris 8, plantar warts 3 and genital warts 5) were treated with applications of Vinca rosea cream twice a day 1-2 hours after application of an ointment containing equal part of 5% salicylic acid and 0.05% tretinoin (1:1). The response after 6 weeks of treatment when compared with a control group of 14 cases of various types of warts applying only 5% salicylic acid and 0.05% tretinoin (1:1) was found to be better in clearing the warts and also preventing recurrences. Record #76 of 101 ID: CN-00421304 AU: Berth Jones J,Hutchinson PE TI: Response rates to current treatment of common warts and evaluation of continued cryotherapy and inosine pranobex for treatment failures. SO: British Journal of Dermatology YR: 1990 VL: 123 NO: Suppl 37 PG: 19 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/304/CN00421304/frame.html CC: SR-SKIN Record #77 of 101 ID: CN-00187719 AU: Pueyo S AU: Criscuolo M AU: Davidovich C AU: Zorzopulos J AU: Pesce A AU: Diaz A TI: Treatment of recrurent common warts with one low dose of intralesional natural human leukocyte interferon alpha SO: J BIOL REGUL HOMEOSTATIC AGENTS YR: 1990 VL: 4 NO: 2 PG: 47-50 XR: EMBASE 1990331698 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/719/CN00187719/frame.html KY: Alpha Interferon --Drug Therapy --Dt/ Verruca Vulgaris --Drug Therapy --Dt/ Analgesia/ Child/ Adult AB: Nine patients with recurrent and long lasting common warts were treated with intralesional Hu-IFN-alpha. The schedule was a single dose per wart, ranged between 105 and 2 x 105 IU. Placebo was aslo administered in 3 of these patients. Complete remission was observed in 7 of the 9 patients. The pattern of warts involution and the possible interferon mechanism of action are discussed. A significant pain relier, produced by interferon injection was observed in the patients with plantar warts and in one patient with subungueal wart. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #78 of 101 ID: CN-00466196 AU: Pueyo S AU: Criscuolo M AU: Davidovich C AU: Zorzopulos J AU: Pesce A AU: Diaz A TI: Treatment of recurrent common warts with one low dose of intralesional natural human leukocyte interferon alpha SO: Journal of Biological Regulators & Homeostatic Agents YR: 1990 VL: 4 NO: 2 PG: 47-50 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/196/CN00466196/frame.html CC: SR-SKIN AB: Nine patients with recurrent and long lasting common warts were treated with intralesional Hu-IFN-alpha. The schedule was a single dose per wart, ranged between 10(5) and 2 x 10(5) IU. Placebo was also administered in 3 of these patients. Complete remission was observed in 7 of the 9 patients. The pattern of warts involution and the possible interferon mechanism of action are discussed. A significant pain relief, produced by interferon injection was observed in the patients with plantar warts and in one patient with subungueal wart Record #79 of 101 ID: CN-00057557 AU: Bart BJ AU: Biglow J AU: Vance JC AU: Neveaux JL TI: Salicylic acid in karaya gum patch as a treatment for verruca vulgaris. SO: Journal of the American Academy of Dermatology YR: 1989 VL: 20 NO: 1 PG: 74-6 PM: PUBMED 2643641 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article AD: Department of Dermatology, Hennepin County Medical Center, Minneapolis, MN 55415. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/557/CN00057557/frame.html KY: Administration, Cutaneous; Clinical Trials as Topic; Double-Blind Method; Hand Dermatoses [drug therapy]; Karaya Gum; Placebos; Random Allocation; Salicylic Acid; Salicylic Acids [administration & dosage] [therapeutic use]; Warts [drug therapy]; Adult; Female; Humans; Male CC: HS-HANDSRCH; SR-SKIN AB: A clinical study was conducted to evaluate the efficacy of a new delivery system for administering salicylic acid for the treatment of verruca vulgaris. The study compared wart resolution among volunteers who used karaya gum patches. The cure rate was 69% for warts treated with patches containing salicylic acid, which was significantly higher (p less than 0.01) than for warts treated with control patches (35%). Record #80 of 101 ID: CN-00185194 AU: Rosado-Cancino MA AU: Ruiz-Maldonado R AU: Tamayo L AU: Laterza AM TI: Treatment of multiple and stubborn warts in children with 1-chloro-2,4dinitrobenzene (DNCB) and placebo. <ORIGINAL> TRATAMIENTO DE VERRUGAS VULGARES MULTIPLES Y RECALCITRANTES CON 1-CLORO-2, 4 DINITROBENCENO (DNCB) O PLACEBO EN PACIENTES PEDIATRICOS SO: DERMATOL REV MEX YR: 1989 VL: 33 NO: 4 PG: 245-252 XR: EMBASE 1990021504 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/194/CN00185194/frame.html KY: 1 Chloro 2,4 Dinitrobenzene --Drug Therapy --Dt/ Verruca Vulgaris -Diagnosis --Di/ Child AB: Fourty pediatric patients with multiple recalcitrant common viral warts were treated with 1-chlore-2, 4-Dinitrobencene (DNCB) and placebo in an open controlled study. Twenty patients received DNCB in acetone and twenty received acetone only. Sixteen patients treated with DNCB and seven patients treated with placebo cured (P < 0.025). The average time of treatment was 7 weeks. The age, sex, number of lesions and their location, previous treatments and time of evolution had not significant influence on the therapeutic response. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #81 of 101 ID: CN-00185710 AU: Kassis V AU: Knudsen EA AU: Thomsen HK AU: Wilkinson W TI: Ultrasound in the treatment of hand and plantar warts SO: J DERMATOL TREAT YR: 1989 VL: 1 NO: 2 PG: 69-70 XR: EMBASE 1990003846 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/710/CN00185710/frame.html KY: Verruca Vulgaris --Therapy --Th/ Verruca Plantaris --Therapy --Th/ Ultrasound CC: HS-HANDSRCH; SR-SKIN AB: A controlled study of wart treatment with continuous ultrasound versus placebo in 39 patients with hand and/or plantar warts was performed. No healing effect of the ultrasound treatment was seen. In the actively treated group, 9 of 20 treated patients (45%) versus 9 of 19 patients in the placebo group (47%) healed during 5 weeks of treatment and 12 weeks follow up. Histological examination of warts after 5 weeks of treatment showed neither any differences in morphology between the two groups of patients nor any changes which could be related to the ultrasound therapy. No noticeable side-effects were reported. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #82 of 101 ID: CN-00062054 AU: Steele K AU: Irwin WG TI: Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice. SO: The Journal of the Royal College of General Practitioners YR: 1988 VL: 38 NO: 311 PG: 256-8 PM: PUBMED 3255811 PT: Clinical Trial; Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/054/CN00062054/frame.html KY: Adolescent; Combined Modality Therapy; Cryosurgery; Lactates [therapeutic use]; Lactic Acid; Salicylic Acids [therapeutic use]; Warts [surgery] [therapy]; Child; Female; Humans; Male CC: SR-SKIN Record #83 of 101 ID: CN-00054502 AU: Spanos NP AU: Stenstrom RJ AU: Johnston JC TI: Hypnosis, placebo, and suggestion in the treatment of warts. SO: Psychosomatic medicine YR: 1988 VL: 50 NO: 3 PG: 245-60 PM: PUBMED 3387508 PT: Clinical Trial; Controlled Clinical Trial; Journal Article AD: Department of Psychology, Faculty of Social Sciences, Carleton University, Ottawa, Canada. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/502/CN00054502/frame.html KY: Adolescent; Hypnosis; Imagination; Placebos; Sex Factors; Suggestion; Warts [therapy]; Adult; Aged; Child; Female; Humans; Male; Middle Aged CC: SR-COMPMED; SR-SKIN AB: Two experiments assessed the effects of psychological variables on wart regression. In Experiment 1, subjects given hypnotic suggestion exhibited more wart regression than those given either a placebo treatment or no treatment. In Experiment 2, hypnotic and nonhypnotic subjects given the same suggestions were equally likely to exhibit wart regression and more likely to show this effect than no treatment controls. In both experiments, treated subjects who lost warts reported more vivid suggested imagery than treated subjects who did not lose warts. However, hypnotizability and attribute measures of imagery propensity were unrelated to wart loss. Subjects given the suggestion that they would lose warts on only one side of the body did not show evidence of a side-specific treatment effect. Record #84 of 101 ID: CN-00191947 AU: Abou-Auda H AU: Soutor C AU: Neveaux JL TI: Treatment of verruca infections (warts) with a new transcutaneous controlled-release system SO: CURR THER RES, CLIN EXP YR: 1987 VL: 41 NO: 4 PG: 552-556 XR: EMBASE 1987132837 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/947/CN00191947/frame.html KY: Pharmacotherapy (0029544)/ Drug Efficacy (0124994)/ Drug Delivery System (0416252)/ Verruca Vulgaris (0051502)/ Salicylic Acid (0042573) CC: SR-SKIN AB: Patients presenting with single and multiple verruca infections (verruca vulgaris) were treated with a new transcutaneous wart removal system. Comparisons were made between individuals treated with transcutaneous patches that delivered salicylic acid (15%) and transcutaneous patches that did not deliver an active drug (control). At the end of the 12-week study period, there was a significantly greater treatment success rate achieved with the medicated patches than with the control patches (P = 0.005). The control group also showed a greater incidence of wart resolution than might be predicted with a placebo. This was attributed to the hydrating and occlusive properties of the transcutaneous patch. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #85 of 101 ID: CN-00175954 AU: Hansen JG AU: Schmidt H TI: Plantar warts. Frequency and cryosurgical treatment. SO: UGESKR-LAEG YR: 1986 VL: 148 NO: 4 PG: 173-174 XR: EMBASE 1986063147 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/954/CN00175954/frame.html KY: verruca vulgaris/ wart virus/ cryosurgery/ plantar wart. incidence/ efficacy.LA:DA. AB: The authors have investigated 133 consecutive patients with plantar warts in general practice. The one-year prevalence was 2.9%. The condition is commonest in the age-group 5-19 years. 28% were solitary warts. No sex differences were observed. A therapeutic trial was undertaken including all of the patients > or = 5 years with solitary warts < or = 6 mm in diameter in which the duration of the condition was less than one year and where no medical treatment had been administered in the course of the past three months. These patients were randomized blindly to receive cryosurgical treatment for either two minutes or 15 seconds. Treatments were administered with intervals of three weeks. Cryosurgical treatment for two minutes duration was found to produce significantly better results than treatment for 15 seconds. Only few sideeffects occurred. The method is easy, effective, acceptable and suitable for use in general practice. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #86 of 101 ID: CN-00361226 AU: TaÔeb A AU: Astar I AU: Maleville J TI: Soft laser treatment of warts: a sophisticated placebo. SO: Dermatologica YR: 1986 VL: 172 NO: 6 PG: 329 PM: PUBMED 3732579 PT: Clinical Trial; Controlled Clinical Trial; Letter US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/226/CN00361226/frame.html KY: Adolescent; Laser Therapy; Warts [therapy]; Adult; Child; Child, Preschool; Humans; Middle Aged CC: HS-HANDSRCH; SR-SKIN Record #87 of 101 ID: CN-00043426 AU: Berman B AU: Davis-Reed L AU: Silverstein L AU: Jaliman D AU: France D AU: Lebwohl M TI: Treatment of verrucae vulgaris with alpha 2 interferon. SO: The Journal of infectious diseases YR: 1986 VL: 154 NO: 2 PG: 328-30 PM: PUBMED 3522759 PT: Clinical Trial; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/426/CN00043426/frame.html KY: Adolescent; Clinical Trials as Topic; Double-Blind Method; Interferon Type I [adverse effects] [therapeutic use]; Leukocyte Count; Recombinant Proteins [adverse effects] [therapeutic use]; Warts [therapy]; Adult; Aged; Female; Humans; Male; Middle Aged CC: SR-SKIN Record #88 of 101 ID: CN-00175748 AU: Gibson JR AU: Harvey SG AU: Barth J AU: Darley CR AU: Reshad H AU: Burke CA TI: A comparison of acyclovir cream versus placebo cream versus liquid nitrogen in the treatment of viral plantar warts. SO: Dermatologica YR: 1984 VL: 168 NO: 4 PG: 178-81 PM: PUBMED 6724070 XR: EMBASE 1984102818 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/748/CN00175748/frame.html KY: Acyclovir [therapeutic use]; Administration, Topical; Adolescent; Drug Evaluation; Freezing; Nitrogen [therapeutic use]; Random Allocation; Skin Diseases [drug therapy] [therapy]; Warts [drug therapy] [therapy]; Adult; Aged; Child; Humans; Middle Aged CC: HS-HANDSRCH; SR-SKIN AB: 52 patients with a clinical diagnosis of verruca plantaris were entered into a randomised study of acyclovir cream versus placebo cream versus liquid nitrogen. 47 completed the initial 8-week assessment period. At first, liquid nitrogen was used as a positive control but after the entry of 33 patients it was discontinued as an initial therapy in order to obtain maximal numbers of patients on the cream treatments. At the end of the 8-week assessment period 5 of 18 (placebo cream), 7 of 18 (acyclovir cream) and 1 of 11 (liquid nitrogen) patients were completely cleared of their plantar warts. Patients who failed to clear on cream or liquid nitrogen treatments after the initial assessment period but who wished to continue therapy were subsequently treated with liquid nitrogen. Of a total of 27 patients treated vigorously with liquid nitrogen, for periods of time ranging from 2 to 34 weeks, only 11 were completely cleared of their warts at the end of the study. It is concluded that liquid nitrogen should not be considered as a routine treatment for plantar warts and that acyclovir cream is no better than placebo in the treatment of this condition. Record #89 of 101 ID: CN-00035613 AU: Androphy EJ AU: Dvoretzky I AU: Maluish AE AU: Wallace HJ AU: Lowy DR TI: Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon. SO: Journal of the American Academy of Dermatology YR: 1984 VL: 11 NO: 2 Pt 1 PG: 197-202 PM: PUBMED 6384282 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/613/CN00035613/frame.html KY: Clinical Trials as Topic; Interferon Type I [therapeutic use]; Skin [pathology]; Skin Diseases [therapy]; Warts [immunology] [pathology] [therapy]; Adult; Child; Child, Preschool; Female; Humans; Male; Middle Aged CC: SR-CHILD; SR-SKIN AB: The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-alpha) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-alpha, four of five IFN-alpha-treated warts regressed; none of the placebo-treated warts responded (p = 0.024). Three patients with EV were treated with systemic IFN-alpha for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-alpha while two who received placebo showed no improvement. The lesions recurred following cessation of therapy. At the completion of therapy with IFN-alpha, histologic normalization was accompanied by a 95% decrease in the number of viral antigencontaining cells in the warts (p less than 0.001). We conclude that warts in EV respond to systemic and intralesional IFN-alpha. Record #90 of 101 ID: CN-00028911 AU: Pazin GJ AU: Ho M AU: Haverkos HW AU: Armstrong JA AU: Breinig MC AU: Wechsler HL AU: Arvin A AU: Merigan TC AU: Cantell K TI: Effects of interferon-alpha on human warts. SO: Journal of interferon research YR: 1982 VL: 2 NO: 2 PG: 235-43 PM: PUBMED 7119508 PT: Case Reports; Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/911/CN00028911/frame.html KY: Dose-Response Relationship, Immunologic; Injections, Intramuscular; Interferon Type I [administration & dosage] [blood] [therapeutic use]; Killer Cells, Natural [immunology]; Time Factors; Warts [immunology] [therapy]; Adult; Female; Humans; Male AB: Two patients with extensive warts which were stable for two years or more were treated with human interferon-alpha to assess the ability of interferon to affect this benign tumor of viral etiology. Intramuscular administration of 96.6 and 135 million units over 12-15 weeks produced softening and decreased scaling of each patient's warts. Double blind, placebo-controlled intralesional injections resulted in progressive disappearance of interferon treated warts. A dose response relationship was shown in eight warts. The minimum effective dose was 1.2 x 10(6) units injected over 15.5 weeks. Record #91 of 101 ID: CN-00191039 AU: Lahti A AU: Hannuksela M TI: Topical immunotherapy with tuberculin jelly for common warts SO: ARCH DERMATOL RES YR: 1982 VL: 273 NO: 1-2 PG: 153-154 XR: EMBASE 1982160207 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/039/CN00191039/frame.html KY: Verruca Vulgaris (0051502)/ Immunotherapy (0068909)/ Delayed Hypersensitivity (0012660)/ Tuberculin (0050029)/ 1 Chloro 2,4 Dinitrobenzene (0055323)/ Topical Agent (0154222) CC: SR-SKIN AB: Twenty-one out-patients with recalcitrant warts resistant to keratolytic and other conventional therapies were chosen for this single-blind study. The mean duration of the warts was 2.9 years in the tuberculin jelly group and 2.7 years in the petrolatum group. Fourteen of the patients used topical tuberculin jelly (Statens Serum Institut, Tuberculin Department, Copenhagen, Denmark) and seven patients yellow petrolatum every other day until the warts disappeared or for a maximum of 4 months. The ointment was applied to the warts nightly using a toothpick and the warts were covered with a piece of porous tape (Scanpor, Norgesplaster A/S, Oslo, Norway) overnight. The warts disappeared completely from eight of the 14 patients in the tuberculin jelly group and from one of the seven in the petrolatum group (P < 0.08, Fisher's exact probability test). The disappearance of warts usually occurred in the 3rd or 4th month. The strength of the tuberculin reactivity was not correlated with the disappearance of the warts. The efficacy of tuberculin jelly in the treatment of warts was not statistically significant in the present study. For ethical reasons the number of patients treated with placebo was restricted. However, tuberculin jelly is one of the antigens available for immunological treatment of problematic warts in countries in which tuberculin sensitivity is high. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #92 of 101 ID: CN-00177882 AU: Schmidt H AU: Jacobsen FK TI: Double-blind randomized clinical study on treatment of warts with a fluorouracil-containing topical preparation. SO: Z-HAUTKR YR: 1981 VL: 56 NO: 1 PG: 41-43 XR: EMBASE 1981096788 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/882/CN00177882/frame.html KY: verruca vulgaris/ placebo/ fluorouracil/ salicylic acid. pharmacotherapy/ double blind procedure.LA:GE. AB: In a double blind trial 60 patients were treaed with a salicylic acidcontaining product against warts (Verrumal(Reg.trademark)) on a fluorouracil basis in comparison to placebo. The trial demonstrated statistically significantly better results for the Verrumal preparation than for the placebo without fluorouracil and without salicylic acid. This product against warts is, therefore, indicated if operative methods are not applicable or refused by the patient. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #93 of 101 ID: CN-00466217 AU: Rossi E AU: Soto JH AU: Battan J AU: Villalba L TI: Intralesional bleomycin in verruca vulgaris. Double-blind study. SO: DermatologÌa. Revista Mexicana YR: 1981 VL: 25 PG: 158-165 DE: RCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/217/CN00466217/frame.html CC: SR-SKIN Record #94 of 101 ID: CN-00185346 AU: Morales-Caballero HG AU: Ruiz-Maldonado R AU: Tamayo L TI: Levamisole in the treatment of warts (double blind study). <ORIGINAL> LEVAMISOL EN EL TRATAMIENTO DE LAS VERRUGAS VULGARES. ESTUDIO DOBLE CIEGO SO: DERMATOLOGIA (MEXICO CITY) YR: 1978 VL: 22 NO: 1 PG: 20-25 XR: EMBASE 1979099309 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/346/CN00185346/frame.html KY: Verruca Vulgaris (0051502)/ Levamisole (0054165)/ Placebo (0037604)/ Drug Screening (0135751)/ Pharmacotherapy (0029544) AB: 50 children with multiple common warts and with similar general characteristics were studied. On a double-blind basis, 29 patients were given levamisole and 31 patients were given placebo. Treatment lasted 10 weeks. No significant difference in the therapeutic result was observed among the 2 groups. Copyright © 2009 Elsevier B. V., Amsterdam. All Rights Reserved. Record #95 of 101 ID: CN-00014244 AU: Bunney MH AU: Nolan MW AU: Williams DA TI: An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. SO: The British journal of dermatology YR: 1976 VL: 94 NO: 6 PG: 667-79 PM: PUBMED 820365 PT: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/244/CN00014244/frame.html KY: Benzalkonium Compounds [therapeutic use]; Clinical Trials as Topic; Cryosurgery; Drug Combinations; Fluorouracil [therapeutic use]; Follow-Up Studies; Glutaral [therapeutic use]; Idoxuridine [therapeutic use]; Lactates [therapeutic use]; Polyethylene Glycols [therapeutic use]; Salicylic Acids [therapeutic use]; Time Factors; Warts [drug therapy] [therapy]; Humans CC: SR-SKIN AB: A series of eleven comparative wart treatment trials undertaken between 1969 and 1975 and involving 1802 patients is described. A method of coding provided groups of patients matched for age, type, number and duration of warts, within which treatments could be randomized. The variation in response to treatment was shown to be influenced significantly by these factors and the level of cure to depend on the proportions of the various response groups within the population under consideration. These proportions were found to vary geographically and at different periods. In all the trials the results were assessed at 12 weeks. In the treatment of hand warts, the percentage cure of patients treated with liquid nitrogen fell significantly from 75 to 40% when the interval between freezings was increased from 3 to 4 weeks. The average number of freezings required for a cure was 3-1 amongst all patients cured by 6 or less freezings at intervals of 2 or 3 weeks. In a two-centre trial there was no significant difference between the percentage cure of patients with hand warts treated with liquid nitrogen (69%) and of those applying a paint containing salicylic and lactic acids (SAL) (67%). Patients receiving both treatments concurrently did better (78%) but the difference was not found to be statistically significant. In the treatment of simple plantar warts the percentage cure for the SAL paint (84%) was found to compare favourably with that for a podophyllin treatment (81%). Only one of the patients cured by the paint in that trial was found to have had a recurrence after 6 months. The paint was found to be satisfactory for use under general practice conditions. Additions to the formula did not alter its effectiveness. In the treatment of mosaic plantar warts the overall percentage cure for the SAL paint in a series of comparative trials (1969-75) was 45%. In these trials it was compared directly with one or more other preparations. No differences were found between its efficacy and that of 10% buffered gluteraldehyde (47%), 40% benzalkonium chloride dibromide (Callusolve 40) (30%) and 5% 5-fluorouracil in dimethyl sulphoxide (53%). Only 25% of thirty-six patients treated with 5% idoxuridine in dimethylsulphoxide were cured. Throughout the trials approximately 30% of patients with hand warts, 20% of those with simple plantar warts and 50% of those with mosaic plantar warts were found to be resistant to treatment. The adoption of treatment with SAL paint for hand warts and simple plantar warts by the general practitioners in the Edinburgh area has proved satisfactory. Only resistant cases are now referred to hospital and these can be treated within a few weeks instead of 4-5 months as was the case in 1969. Record #96 of 101 ID: CN-00401097 AU: Goncalves JC TI: 5-Fluorouracil in the treatment of common warts of the hands. A double-blind study SO: British Journal of Dermatology YR: 1975 VL: 92 NO: 1 PG: 89-91 DE: CCT US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/097/CN00401097/frame.html CC: HS-HANDSRCH; SR-SKIN AB: A double-blind study was carried out to compare the action of 5-fluorouracil and 10% salicylic acid varnish with that of a 10% salicylic acid varnish on common warts. Fifty per cent of the lesions disappeared with the combined preparation and only 4% with the varnish containing salicylic acid alone. The presence of warts on the hands of 45.8% of the female workers of a fowl slaughterhouse is described Record #97 of 101 ID: CN-00013226 AU: Stevens DA AU: Ferrington RA AU: Merigan TC AU: Marinkovich VA TI: Randomized trial of transfer factor treatment of human warts. SO: Clinical and experimental immunology YR: 1975 VL: 21 NO: 3 PG: 520-4 PM: PUBMED 1106927 PT: Clinical Trial; Journal Article; Randomized Controlled Trial US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/226/CN00013226/frame.html KY: Adolescent; Clinical Trials as Topic; Placebos; Transfer Factor [therapeutic use]; Warts [therapy]; Wiskott-Aldrich Syndrome [therapy]; Adult; Child; Female; Humans; Male CC: SR-CHILD; SR-SKIN AB: Dialysed transfer factor, prepared from the leucocytes of a donor whose warts had undergone recent spontaneous regression, was used in the treatment of a child with the Wiskott--Aldrich syndrome. The child then had a spontaneous regression at multiple warty areas. A similar relationship was seen in four otherwise healthy patients in a pilot study. A randomized double-blind study of thirty patients failed to confirm a causal relationship between the transfer factor therapy (equivalent to 2-1 X 10(8) leucocytes) and wart regressions. The need for randomized trials of transfer factor therapy for diseases with a variable natural history is emphasized. Record #98 of 101 ID: CN-00009970 AU: Braatz JH AU: McAlistar BR AU: Broaddus MD TI: Ultrasound and plantar warts: a double blind study. SO: Military medicine YR: 1974 VL: 139 NO: 3 PG: 199-201 PM: PUBMED 4206165 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/970/CN00009970/frame.html KY: Adolescent; Clinical Trials as Topic; Foot Diseases [therapy]; Placebos; Ultrasonic Therapy; Warts [therapy]; Adult; Child; Humans CC: SR-REHAB; SR-SKIN Record #99 of 101 ID: CN-00568809 AU: Locke RK AU: Zang K TI: Controlled intralesional deposition of a sclerotic agent in verruca therapy. SO: International journal of dermatology YR: 1970 VL: 9 NO: 4 PG: 278-82 PM: PUBMED 5494023 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/809/CN00568809/frame.html KY: Anesthesia, Local; Ascorbic Acid [administration & dosage]; Bismuth [administration & dosage]; Foot Dermatoses [drug therapy] [therapy]; Injections; Mepivacaine; Methods; Sclerosing Solutions [administration & dosage]; Vitamin A [administration & dosage]; Warts [drug therapy] [therapy]; Humans CC: HS-HANDSRCH; SR-SKIN Record #100 of 101 ID: CN-00002068 AU: McKnight AG TI: Assessment of treatment of plantar warts. SO: The Ulster medical journal YR: 1968 VL: 37 NO: 1 PG: 40-2 PM: PUBMED 4872117 PT: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/068/CN00002068/frame.html KY: Clinical Trials as Topic; Formaldehyde [administration & dosage]; Warts [drug therapy] [surgery] [therapy]; Humans Record #101 of 101 ID: CN-00001416 AU: Dudek SZ TI: Suggestion and play therapy in the cure of warts in children: a pilot study. SO: The Journal of nervous and mental disease YR: 1967 VL: 145 NO: 1 PG: 37-42 PM: PUBMED 4860932 PT: Clinical Trial; Controlled Clinical Trial; Journal Article US: http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/416/CN00001416/frame.html KY: Adolescent; Physician-Patient Relations; Placebos; Projective Techniques; Suggestion; Warts [therapy]; Child; Child, Preschool; Female; Humans; Male CC: SR-COMPMED
