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Liquid Nitrogen Treatment Information Sheet Your skin lesion(s) has been treated by cryosurgery or “freezing” using a cold solution of liquid nitrogen. The exact way in which the treatment works is unclear. In some cases it causes local destruction of damaged skin cells. In other conditions it may encourage your immune system to produce antibodies, to destroy warts for example. In 24-48 hours a blister may appear at the site of the treatment. This may even fill up with a bloody fluid. Many people are alarmed at the size of the blister and think that the treatment has gone wrong; however this is a normal response to the treatment. If you experience discomfort with the blister then you may release the pressure/fluid with a clean needle. Do not remove the skin once you have released the fluid, as it will act as a natural bandage. If you are having warts treated you may need several treatments to resolve the warts. If you are concerned, you may reach one of the dermatology nurses at 1-705-7757546.