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Diseases of a Noninfectious Nature Disease Types Associated with Non-living Agents 1) 2) 3) 4) nutritional neoplastic (cancer) toxins miscellaneous origin...the rest. Nutritional Diseases proper nutrition is essential to the health of all animals nutritional diseases in fish are common and associated with either deficiencies or excesses estimating the role of malnutrition in disease outbreaks involving opportunistic pathogens is essential not really a problem among wild fish populations because they select a balanced diet What you Can Do to Avoid Malnutrition estimate proper ration requirement insure that moisture content is taken into consideration when feeding...why? are dietary supplements required? nutrient requirements proper feeding practices Nutritional Requirements protein and amino acids fatty acids protein:energy ratio vitamins minerals possibly fiber Nutritional Diseases of Fish Most are chronic in nature (develop slowly) Six week interval is common. Early disease symptoms may be subtle and difficult to interpret Why? 1) often only moderate nutrient deficiencies or excesses are involved 2) signs of the disease can often be masked by secondary pathogens Nutritional Disease Diagnosis Requires observation of external and internal signs Quantitative clinical chemistry on blood, tissues, fluids of infected fish Histopathalogical (cellular) examination Feed analyzed for deficiencies Evaluate feed management Pathological Syndromes protein/amino acids (AA) Reduced or abnormal amino acid intake in fish/shrimp results in reduced biosynthesis of many vital substances: enzymes, hormones, certain pigments Certain amino acids are necessary for fat/carbohydrate metabolism Amino acids also required for formation of purines, pyrimidines, i.e. DNA, RNA Diagnosis of protein/AA malnutrition is difficult!! Protein/Amino Acid Deficiency Observation: poor FCR Anemia? Challenge: protein/AA deficiency signs similar to disease caused by other etiological agents Most common sign: reduction of growth Amino Acid Deficiency Tryptophan deficit = scoliosis and lordosis Tryptophan or sulfur amino acid deficiency cataracts* Excesses of leucine or isoleucine increases valine requirement (antagonism) Dietary Fats and Lipids Pathological conditions associated with: 1) 2) 3) high fat intake or dietary fat deficiency in essential fatty acids or rancidification (peroxidation) High fat intake = fatty liver/obesity (check liver for fat droplets in water) Coldwater species and high saturated fat don't mix (reduced digestibility, flexibility) Deficiency of linolenic acid = malpigmentation, fin erosion Fatty Acids Unsaturated fats go rancid (spoil). This produces peroxides and other toxic compounds. Peroxidation causes a syndrome similar to muscular dystrophy (usually associated with alpha tocopherol Vit E) Carbohydrates Excess soluble carbohydrates cause hyperglycemia, build-up of liver glycogen and enlargening of the liver Lethargy, darkening of color, poor appetite Might cause increased susceptibility to disease from bacteria, fungi, parasites Liver malfunctions possible Mineral Deficiencies Hard to evaluate due to difficulty of removing minerals from diet and water Goiter in fish? Yep! Zinc implicated in eye cataracts Low iron = anemia Phosphorus deficiency = lordosis, skeletal deformities, skull size Treatments for Nutritional Diseases Store feed properly (cool and dry) Use feed by expiration date (90 days for vitamins) Feed correct amount to fish (don’t underfeed) If necessary, have feed analyzed ($$$$) Only use feed from reputable sources. If you suspect bad feed, throw it out (even if it’s 5 tons!) Neoplastic (Tumor-like) Diseases cell regeneration, growth, replacement occurs at a specific rate for specific tissues (REM: protein turnover?) if cell growth and proliferation occurs at an uncontrolled rate, you have a tumor neoplasia = appearance of tumor mass hyperplasia = uncontrolled proliferation two types of tumors: benign and malignant benign tumors cause fewer negative effects than malignant ones Malignant Tumors cause formation of altered cells, altered characteristics are passed on to other generations spread into blood, lymph or other organs is known as metastasis tumors are also classified by tissue of origin, thus "basal cell carcinoma" or "lymphoma" oncology or tumor study of fish is relatively recent Causes of Neoplasia Obscure causes, no single etiology can be found Cellular changes result of multiple causes Interacting factors: age, heredity, immunological factors, presence of carcinogens, oncogenic viruses Fish age and susceptibility may not be true since fish continue to grow Heredity: thyroid carcinoma in trout (kill these?) Causes of Neoplasia Heredity: susceptibility to aflatoxin, some species more so than others Presence of carcinogens: industrialized areas = gonadal, liver tumors Chlorination = neuroblastomas Age effect has been shown in terms of aquatic pollutants (even for embryos) Malignant Tumors of Fish Neoplasms have been found in nearly all organs and cell types of fishes Incidence is quite low with typically little effect on entire population Major malignant tumor in fish is "hepatoma" or liver cell carcinoma, first reported in rainbow trout in 1933. Result of feeding cottonseed meal that had spoiled in the field, producing the fungus Aspergillus flavus The toxins from fungal spores were identified as the primary etiological agent Liver Cell Carcinoma: aflatoxicosis There are no outward signs of aflatoxicosis or hepatoma early on. Enlargement of the liver, followed by emaciation As disease progresses, liver nodules grow and contact other organs Confirmatory diagnosis is via histopathology/oncology of the tumor Hepatoma Therapy and Control There is no cure! Must eliminate aflatoxin from the feed. Usually eliminated from feeds by addition of proprionic acid or ammonia treatment of the feedstuff Prognosis: morbidity may reach 70% in culture facilities Linear relationship between cottonseed meal intake and incidence of hepatoma Idiopathic Epidermal Hyperplasia Idiopathic Epidermal Hyperplasia (striped bass epithelium) Stomatopapilloma in European Eel X-cell Lesions in Gill Cavity of a blue whiting Fibrosarcoma on a Goldfish Mass in the throat of a porkfish caused by a thyroid tumor Osteomas on the rib and vertebral column of an Atlantic croaker Benign Tumors of Fishes have been identified for many fish species throughout the world most cases are concerned with individual fish and not the entire population benign tumors are usually by oncogenic viruses or bacteria and may be more numerous than other types good example in fish is the bacterium Mycobacterium fortuitum which stimulates production of tumor-like masses in the kidney, liver or spleen other agents include copepod parasite which produce fibromas where they attach