Download naproxen tablets

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Description of Naproxen:
Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
It works by reducing hormones that cause inflammation and pain in the body. Naproxen
is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing
spondylitis, tendinitis, bursitis, gout, or menstrual cramps.
Naproxen is a proprionic acid derivative related to the arylacetic acid group of
nonsteroidal anti-inflammatory drugs.
The chemical names for naproxen and naproxen sodium are (S)-6-methoxy-a-methyl-2naphthaleneacetic acid and (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid, sodium
salt, respectively. Naproxen and naproxen sodium have the following structures,
respectively:
Naproxen (R=-COOH) C14H14O3 mol wt 230.26
naproxen sodium (R=-COONa) C14H13NaO3 mol wt 252.23
Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3.
Naproxen sodium has a molecular weight of 252.23 and a molecular formula of
C14H13NaO3.
Naproxen is an odorless, white to off-white crystalline substance. It is lipid-soluble,
practically insoluble in water at low pH and freely soluble in water at high pH. The
octanol/water partition coefficient of naproxen at pH 7.4 is 1.6 to 1.8. Naproxen sodium
is a white to creamy white, crystalline solid, freely soluble in water at neutral pH.
NAPROSYN (naproxen tablets) is available as yellow tablets containing 250 mg of
naproxen, pink tablets containing 375 mg of naproxen and yellow tablets containing 500
mg of naproxen for oral administration. The inactive ingredients are croscarmellose
sodium, iron oxides, povidone and magnesium stearate.
Brand Name & Manufacturer Name of Naproxen:
Brand Name
ANAFLEX
Contains
Dosage
Form
Naproxen sodium 250mg & Tablet
Manufacturer
ACI Ltd.
Price(Tk.)
250mg x 50s
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500mg/tablet
pack: 250.00
MRP; 500mg x
30s pack: 270.00
MRP
ANAFLEX
Gel
Naproxen 10% w/w gel
preparation
Gel
ACI Ltd.
15gm pack:
62.00 MRP
ANAFLEX
SR
Naproxen sodium
500mg/tablet
Tablet
(sustained
release)
ACI Ltd.
500mg x 20s
pack: 280.00 IP
ARNEX
Naproxen sodium
500mg/tablet
Tablet
500mg x 30s
Silva
Pharmaceuticals pack: 180.00
MRP
Ltd.
BPXEN
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 200.00
Bristol Pharma
MRP; 500mg x
Ltd.
50s pack: 375.00
MRP
COSNAP
Naproxen sodium
250mg/tablet
Cosmo Pharma 250mg x 50s
pack: 150.00
Laboratories
MRP
Ltd.
Tablet
Drug
International
Ltd.
DIPROXEN
Naproxen sodium 250mg &
Tablet
500mg/tablet
DIPROXEN
CR-500
Naproxen sodium
500mg/tablet
Tablet
Drug
(controlled International
release)
Ltd.
DIPROXEN
Gel
Naproxen 10% w/w gel
preparation
Gel
Drug
International
Ltd.
250mg x 100s
pack: 420.00
MRP; 500mg x
50s pack: 350.00
MRP
500mg x 30s
pack: 300.00
MRP
15gm pack:
60.00 MRP
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 200.00
SOMATEC
Pharmaceuticals MRP; 500mg x
50s pack: 350.00
Ltd.
MRP
NAID
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 200.00
Pacific
Pharmaceuticals MRP; 500mg x
50s pack: 376.00
Ltd.
MRP
NAPASIN
Naproxen sodium
Skylab
FRITT
Tablet
50s pack: 210.00
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250mg/tablet
NAPEC
Pharmaceuticals MRP
Ltd.
Naproxen sodium 250mg &
Tablet
500mg/tablet
Unimed &
Unihealth
Manufacturers
Ltd.
250mg x 30s
pack: 120.00
MRP; 500mg x
30s pack: 240.00
MRP
250mg x 50s
pack: 200.00
MRP; 500mg x
30s pack: 210.00
MRP
NAPIUM
Naproxen sodium 250mg &
Tablet
500mg/tablet
Kumudini
Pharma Ltd.
NAPIX-500
Naproxen sodium
500mg/tablet
500mg x 30s
Modern
Pharmaceuticals pack: 140.00
MRP
Ltd.
Brand Name
NAPREN
NAPRO
NAPRO-A
Contains
Naproxen sodium
250mg/tablet
Tablet
Dosage
Form
Tablet
Naproxen sodium 250mg &
Tablet
500mg/tablet
Naproxen sodium 250mg &
Tablet
500mg/tablet
NAPROBEN Naproxen sodium
500mg/tablet
500
Tablet
Manufacturer
Price(Tk.)
Alco Pharma
Ltd.
50s pack: 150.00
MRP
Aristopharma
Ltd.
250mg x 50s
pack: 210.00
MRP; 500mg x
30s pack: 210.00
MRP
Acme
Laboratories
Ltd.
250mg x 100s
pack: 400.00
MRP; 500mg x
30s pack: 210.00
MRP
Benham
500mg x 30s
Pharmaceutical
pack: 180.00 IP
Ltd.
NAPROCID
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 30s
pack: 120.05
Gaco
MRP; 500mg x
Pharmaceuticals
30s pack: 210.00
MRP
NAPROSON
Naproxen sodium
275mg/tablet
Jayson
50s pack: 202.00
Pharmaceuticals
IP
Ltd.
Tablet
NAPROSYN Naproxen sodium 250mg & Tablet
Roche
250mg x 50s
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500mg/tablet
pack: 331.50
Bangladesh
Pharmaceuticals MRP; 500mg x
50s pack: 629.50
Ltd.
MRP
NAPROX
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 250.00
Eskayef
MRP; 500mg x
Bangladesh Ltd.
50s pack: 400.00
MRP
NAPROX
Naproxen sodium
125mg/5ml: suspension
Suspension
50ml bot: 30.00
Eskayef
Bangladesh Ltd. MRP
NAPROX
Naproxen 10% w/w gel
preparation
Gel
15gm pack:
Eskayef
Bangladesh Ltd. 60.00 MRP
NAPROXEN
Naproxen sodium
500mg/tablet
Tablet
Amico
Laboratories
Limited
NAPROXIN
NAPRYN
NAPSOD
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 30s
pack: 127.20
Ambee
Pharmaceuticals MRP; 500mg x
30s pack: 206.70
Ltd.
MRP
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 275.00
Health Care
Pharmaceuticals MRP; 500mg x
30s pack: 270.00
Ltd.
MRP
Naproxen sodium 275mg &
Tablet
550mg/tablet
Unimed &
Unihealth
Manufacturers
Ltd.
NAPTODIN- Naproxen sodium
500mg/tablet
500
Brand Name
500mg x 30s
pack: 210.00
MRP
Contains
Tablet
Dosage
Form
275mg x 30s
pack: 120.00
MRP; 550mg x
30s pack: 240.00
MRP
500mg x 50s
Desh
Pharmaceuticals pack: 350.00
MRP
(Pvt.) Ltd.
Manufacturer
Price(Tk.)
SONAP
Naproxen sodium 250mg &
Tablet
500mg/tablet
500mg x 30s
Square
Pharmaceuticals pack: 150.00
MRP
Ltd.
SUXEN
Naproxen 10% w/w gel
preparation
15gm pack:
Supreme
Pharmaceutical 60.00 MRP
Gel
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Incepta
15gm pack:
Pharmaceuticals
62.00 MRP
Ltd.
TICOFLEX
Naproxen sodium 250mg &
Tablet
500mg/tablet
TICOFLEX
Naproxen sodium
125mg/5ml: suspension
TICOFLEX
Naproxen 10% w/w gel
preparation
Gel
Incepta
50ml bot: 35.00
Pharmaceuticals
MRP
Ltd.
TICOFLEX
SR
Naproxen sodium
500mg/tablet
Tablet
(sustained
release)
250mg x 50s
pack: 200.00
Incepta
Pharmaceuticals MRP; 500mg x
50s pack: 350.00
Ltd.
MRP
TOFA
Naproxen sodium 250mg &
Tablet
500mg/tablet
Kemiko
15gm pack:
Pharmaceuticals
60.00 MRP
Ltd.
Naproxen sodium 250mg &
Tablet
500mg/tablet
250mg x 50s
pack: 200.00
Renata Limited MRP; 500mg x
50s pack: 350.00
MRP
Naproxen sodium
500mg/tablet
250mg x 50s
pack: 200.00
Apex
Pharmaceuticals MRP; 500mg x
30s pack: 240.00
Ltd
MRP
XENAPRO
XPRO
Clinical Information:
Naproxen Indications:
1.
2.
3.
4.
5.
6.
7.
8.
9.
ankylosing spondylitis
arthralgia
bone pain
bursitis
dental pain
dysmenorrhea
fever
gouty arthritis
headache
Incepta
30s pack: 240.00
Suspension Pharmaceuticals
MRP
Ltd.
Tablet
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10. heterotopic ossification
11. juvenile rheumatoid arthritis (JRA)
12. migraine
13. migraine prophylaxis
14. mild pain
15. moderate pain
16. myalgia
17. osteoarthritis
18. rheumatoid arthritis
19. tendinitis
Side Effetcs of Neproxen:
1. Common

heartburn, nausea, or stomach/abdominal pain
2. Less common
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
dizziness
drowsiness
vomiting
diarrhea
headache
tiredness (fatigue)
loss of appetite
constipation
bloating or swelling, especially of the legs and feet*
peptic (stomach) ulcers*
bleeding from the stomach or intestines*
nervousness
anxiety
depression
3. Rare
1.
2.
3.
4.
5.
decreased hearing
vision changes*
double vision*
hepatitis (liver inflammation)*
liver damage, which may cause yellow skin or eyes (jaundice)*
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6.
7.
8.
9.
10.
11.
12.
13.
14.
rash and itching*
high blood pressure*
low white blood cell count with increased risk of infection
low platelet count with increased risk of bleeding
low red blood cell count (anemia) which can cause tiredness and other symptoms
kidney damage (usually gets better after medicine is stopped)
kidney failure
allergic reaction with trouble breathing, raised itchy welts on the skin, or swelling
of the face, mouth, or throat*
heart attack or stroke*
Contraindication of Naproxen:
Naproxen delayed-release tablets are contraindicated in patients with known hypersensitivity to
naproxen and naproxen sodium.
Naproxen delayed-release tablets should not be given to patients who have experienced asthma,
urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal,
anaphylactic-like reactions to NSAIDs have been reported in such patients.
Naproxen delayed-release tablets are contraindicated for the treatment of peri-operative pain in
the setting of coronary artery bypass graft (CABG) surgery
Precaution of Naproxen:
1. Before taking naproxen, tell your doctor or pharmacist if you are allergic to it; or to
aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other
allergies. This product may contain inactive ingredients, which can cause allergic
reactions or other problems. Talk to your pharmacist for more details.
2. Before taking this medication, tell your doctor or pharmacist your medical history,
especially of: asthma (including a history of worsening breathing after taking aspirin or
other NSAIDs), blood disorders (such as anemia, bleeding/clotting problems), growths in
the nose (nasal polyps), heart disease (such as congestive heart failure, previous heart
attack), high blood pressure, kidney disease, liver disease, severe loss of body water
(dehydration), stroke, throat/stomach/intestinal problems (such as bleeding, heartburn,
ulcers).
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3. This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any
activity that requires alertness until you are sure you can perform such activities safely.
4. This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially
when combined with this medicine, may increase your risk for stomach bleeding. Limit
alcohol and stop smoking. Consult your doctor or pharmacist for more information.
5. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure,
tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when
outdoors.
6. Some naproxen products contain salt (sodium). Tell your doctor if you are on a saltrestricted diet.
7. Before having surgery, tell your doctor or dentist about all the products you use
(including prescription drugs, nonprescription drugs, and herbal products).
8. Older adults may be more sensitive to the side effects of this drug, especially
stomach/intestinal bleeding.
9. Tell your doctor if you are pregnant or if you plan to become pregnant. During
pregnancy, this medication should be used only when clearly needed. It is not
recommended for use during the first and last trimesters of pregnancy due to possible
harm to the unborn baby and interference with normal labor/delivery. Discuss the risks
and benefits with your doctor before using this medication.
10. This drug passes into breast milk and may have undesirable effects on a nursing infant.
Consult your doctor before breast-feeding.
Dosage of Naproxen:
Usual Adult Dose for Ankylosing Spondylitis
Initial: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a
day. The initial dose for naproxen sodium controlled-release is two 375 mg tablets (750 mg)
orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally
once a day.
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Maintenance: May be increased to a daily maximum of 1500 mg (naproxen) or 1650 mg
(naproxen sodium) in 2 divided doses, for limited periods up to 6 months. In patients who
tolerate lower doses well, the dose of naproxen sodium controlled-release may be increased to
two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited
periods.
Usual Adult Dose for Rheumatoid Arthritis
Initial: 250 mg to 500 mg (naproxen) or 275 mg to 550 mg (naproxen sodium) orally twice a
day. The initial dose for naproxen sodium controlled-release is two 375 mg tablets (750 mg)
orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally
once a day.
Maintenance: May be increased to a daily maximum of 1500 mg (naproxen) or 1650 mg
(naproxen sodium) in 2 divided doses, for limited periods up to 6 months. In patients who
tolerate lower doses well, the dose of naproxen sodium controlled-release may be increased to
two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited
periods.
Usual Adult Dose for Acute Gout
750 mg (naproxen) or 825 mg (naproxen sodium) orally one time, followed by 250 mg
(naproxen) or 275 mg (naproxen sodium) every 8 hours until the gouty attack has resolved,
usually 2 to 3 days. The recommended dose of naproxen sodium controlled-release is two to
three 500 mg tablets (1000 to 1500 mg) orally on the first day, followed by two 500 mg tablets
(1000 mg) orally daily until the attack has subsided.
Usual Adult Dose for Bursitis
550 mg naproxen sodium orally once, followed by 550 mg naproxen sodium every 12 hours, or
275 mg (naproxen sodium)/250 mg (naproxen) every 6 to 8 hours as needed. Titrate to a
maximum daily dose of 1100 mg naproxen sodium or 1000 mg naproxen. The recommended
initial dose of naproxen sodium controlled-release is two 500 mg tablets (1000 mg) orally once a
day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500
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mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should
not exceed two 500 mg tablets (1000 mg).
Usual Adult Dose for Tendonitis
550 mg naproxen sodium orally once, followed by 550 mg naproxen sodium every 12 hours, or
275 mg (naproxen sodium)/250 mg (naproxen) every 6 to 8 hours as needed. Titrate to a
maximum daily dose of 1100 mg naproxen sodium or 1000 mg naproxen. The recommended
initial dose of naproxen sodium controlled-release is two 500 mg tablets (1000 mg) orally once a
day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500
mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should
not exceed two 500 mg tablets (1000 mg).
Usual Adult Dose for Dysmenorrhea
550 mg naproxen sodium orally once, followed by 550 mg naproxen sodium every 12 hours, or
275 mg (naproxen sodium)/250 mg (naproxen) every 6 to 8 hours as needed. Titrate to a
maximum daily dose of 1100 mg naproxen sodium or 1000 mg naproxen.
Over-the-counter preparation: naproxen sodium 220 mg orally every 8 hours as needed. Do not
exceed 2 caplets in any 8- to 12-hour period.
The recommended initial dose of naproxen sodium controlled-release is two 500 mg tablets
(1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets
(1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the
total daily dose should not exceed two 500 mg tablets (1000 mg).
Usual Adult Dose for Pain
550 mg naproxen sodium orally once, followed by 550 mg naproxen sodium every 12 hours, or
275 mg (naproxen sodium)/250 mg (naproxen) every 6 to 8 hours as needed. Titrate to a
maximum daily dose of 1100 mg naproxen sodium or 1000 mg naproxen.
Over-the-counter preparation: naproxen sodium 220 mg orally every 8 hours as needed. Do not
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exceed 2 caplets in any 8- to 12-hour period.
The recommended initial dose of naproxen sodium controlled-release is two 500 mg tablets
(1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets
(1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the
total daily dose should not exceed two 500 mg tablets (1000 mg).
Usual Geriatric Dose for Pain
Over-the-counter preparation - 220 mg (naproxen sodium) orally every 12 hours or 250 mg
(naproxen) orally every 8 hours as needed.
Usual Pediatric Dose for Fever
Dosage guidelines are based on naproxen:
Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to
12 hours.
Usual Pediatric Dose for Pain
Dosage guidelines are based on naproxen:
Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to
12 hours.
Usual Pediatric Dose for Juvenile Rheumatoid Arthritis
Dosage guidelines are based on naproxen:
Greater than or equal to 2 years: 5 mg/kg orally twice a day. Maximum dose: 1000 mg/day.