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UNIVERSITY OF THE WESTERN CAPE MODULE DESCRIPTOR: NEW MODULES Version Name of new module Applications of Structural Biology Rationale for introduction of new module Protein structure is central to the modern understanding of biology and to biotechnological applications including the design of medicines and vaccines, agrichemicals and enzymes for industrial processes. This module will provide an in-depth introduction to protein structure aspects of virology, membrane ion transport, and structure-based drug design. No similar module is offered at this level anywhere in South Africa. Programme (s) in which new module will be offered Programme Faculty (if also prescribed for programmes not in your faculty, please indicate date of agreement) PG Diploma in Structural Biology UWC Faculty of Natural Sciences UCT Science Faculty Home Department Clinical Laboratory Sciences, UCT Module description (Header) Applications of Structural Biology . Generic module name Alpha-numeric code Module numeric code (if available) Structural Biology STB 705 Core/ Elective Core Credit Value Duration Module Type Level Main Outcomes Main Content Pre-requisites Co-requisites Prohibited Combinations Breakdown of Learning Time (example) Contact with lecturer / tutor: Assignments & tasks: Tests & examinations: Practicals: Self study Project Total Learning Time Methods of Student Assessment 15 credits 6 weeks P 8 The ability to *interpret the structure-function relationships of ion transport through membranes and the mechanism and ligand binding of the eye's photo receptor rhodopsin. * understand the rational basis for the design of cardiovascular and anti-inflammatory drugs. * describe viral capsid structures * understand the structural basis of the immune response * design vaccines and anti-viral agents the hydrophobic effect and how it leads to deformable membranes in which proteins can function. facilitated transport across membranes and the structure of ion channels active transport against a concentration gradient using rhodopsin and Ca-ATPase as examples the nature of ATP sites in proteins the structure and funstion of angiotensin converting enzyme approaches to rational drug design virus capsid structures viral immunology vaccine design and antiviral agents structure-based drug design and high throughput screening. Computational and Mathematical Primer, Cell Biology, Principles of Protein Structure. Protein Crystallography, Protein NMR None Hours 60 40 5 0 35 10 150 Students will be assessed on the basis three oral presentations and their write up of an assignment. Moderation will be internal in consultation with members of the teaching team.