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Project Form
Name of the research project:
Odontogenesis and regeneration of periodontal tissues
Institute of Animal Physiology and Genetics
(Academy of Sciences of the Czech Republic, v.v.i.) in close cooperation with
the Research Centre of Stomatology
Veveri 97
602 00 Brno 2, Czech Republic
Project Leader (Mentor):
Ivan Misek, Prof. D.V.M. Ph.D.
Email: [email protected]
Phone: +420 541 212 292, (fax: +420 541 212 988, cell phone: +420 724 977 448)
Description of the project:
The project is focused on tooth development and morphogenesis of tooth
anlagen as well as related structures. It is based on signalling, proliferation,
programmed cell death, differentiation and redistribution of single cell populations
within the tooth primordia development. Although regulation of tooth crown
morphogenesis is well known and tissue engineering and tooth regeneration are
becoming a realistic possibility, information on proper morphogenetic processes
within tooth primordia, including proliferation, differentiation, distribution and death
of cells is still incomplete. Hitherto studies on cell proliferation concentrated as a
rule on the region surrounding the enamel knot – a structure regarded as a
signalling centre controlling the shape of the future crown, and on the cervical loop,
where the existence of stem cells is affirmed. Our prospective research is focused
on signalling within tooth morphogenesis, proliferating processes and apoptosis in
different eutherians (pig, reptiles). The study is focused also on complete
development of normodont dentition using an unique pig model with aim to
characterize it as a suitable reference model of odontogenesis. This approach could
contribute to the generalization of results obtained from studies of highly specialized
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INTERNATIONAL ASSOCIATION of DENTAL STUDENTS
Name and adress of the department:
c/o FDI World Dental Federation Tour de Cointrin Avenue Louis Casai 84 Case Postale 3 1216 Cointrin – Genève Switzerland Web: www.iads-web.org
International Dental Research Program
What will be the student’s involvement within the research project?
The students will get a chance to participate, observe and also assist in
research and the experiments.
The students will acquaint with basic procedures and techniques of
experimental embryology, odontology, molecular biology, tissue engineering and get
the unique chance to look to the possible future of their jobs.
Requirements:
Is there any special knowledge, skills or certain level of studies required?
Advanced knowledge in developmental biology, tissue engineering and
laboratory methods are required.
Language(s) of use: English
What is the minimum number of weeks available to the students who
participate within the research project?: 2 weeks
Hours of work per day: 4-8 hours
Available months:
July-September
How many students can be accepted to participate within the research
project? 1-2 students
Special remarks: -
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INTERNATIONAL ASSOCIATION of DENTAL STUDENTS
What practical skills and knowledge would the student acquire during the
research project?
c/o FDI World Dental Federation Tour de Cointrin Avenue Louis Casai 84 Case Postale 3 1216 Cointrin – Genève Switzerland Web: www.iads-web.org
dentition of laboratory rodents (mice, rats). The results could extend the current
knowledge and contribute to the understanding of principles and mechanisms of
odontogenesis and to the explanation of evolution of mammalian dentition and
adjacent orofacial structures.
Current odontological research aims to analysis of cell and molecular
interactions, but also tends to integrate the knowledge in the general concept of
tissues and organs to understand development, homeostasis, disorder of related
craniofacial structures and possible regeneration of periodontal tissues. Therefore,
the proposed research follows these strategies and covers topics from molecular
investigations up to broader applications.