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Title Code Level Credit rating Pre-requisites Type of module Aims Learning outcomes/objectives Pharmacology and Therapeutics QPM21 7 20 Normal entry requirements to the course Distance learning with associated residential week To gain an understanding of anatomy and physiology and to appreciate the pathology of exemplar common diseases. To understand the principles of drug action. To appreciate aspects of drug absorption, distribution, metabolism and excretion and to understand to mathematical principles of pharmacokinetics. To gain a knowledge of the mechanisms of action and adverse effects of drug treatments used to control exemplar disorders. To appreciate the phenomenon of drug interactions. To understand the principles of drug discovery, drug testing and clinical trials. On completion of this module the student should be able to: Content discuss the processes involved in normal cellular metabolism and replication with relation to drug actions. describe the normal physiological processes involved in the control of exemplar systems such as the autonomic nervous system, the cardiopulmonary system, the endocrine system and the central nervous system and explain related disease processes. discuss mechanisms of drug action and structure-activity relationship. evaluate factors influencing drug absorption, distribution, metabolism and excretion. give reasoned explanations of mechanisms of drug action in the treatment of common diseases. explain mechanisms of adverse drug reactions and drug interactions. demonstrate an understanding of, and evaluate, the processes of drug discovery within the pharmaceutical industry. Principles of drug actions and effects: the dose-response relationship; mechanisms of drug action; the nature of receptors; variations in receptor distribution and population. Drugs acting on the autonomic nervous system: the anatomy of the peripheral nervous system; drugs affecting the nerve impulse; neuromuscular blockers; drugs acting on the sympathetic nervous system; drugs acting on the parasympathetic nervous system. The central nervous system and drugs used in psychiatry: general anaesthetics; narcotic analgesics; anticonvulsant agents; drugs used in the treatment of anxiety; drugs used to induce sleep; drugs used to treat mania; drugs used in the treatment of psychoses; antidepressant agents; drugs used in the treatment of neurodegenerative disorders; Parkinson’s disease; Huntington’s Chorea; Alzheimer’s disease; drug dependence and substance abuse. Content (continued) Teaching and learning strategies Learning support The treatment of cardiovascular disorders: essential physiology of the cardiovascular system; disorders of cardiac rhythm and their treatment; heart failure and its treatment; hypotension and its treatment; hypertension and its treatment. Drugs affecting the blood and its composition: drugs acting on blood cell formation and activity; drugs affecting haemostasis; drugs affecting plasma composition. The treatment of respiratory disorders: the physiological control of respiration; disorders of the respiratory system; drugs affecting the respiratory system. Drugs acting on the gastrointestinal tract, bladder and uterus: drugs acting on the gastrointestinal tract; the treatment of vomiting; the treatment of diarrhoea; agents used for the treatment of constipation; drugs acting on the bladder; drugs acting on the uterus. Pharmacological manipulation of the endocrine system: the treatment of thyroid disorders and therapeutic use of thyroid hormones; disorders of the endocrine control of calcium balance and their treatment; disorders of the endocrine pancreas and their treatment; disorders of the adrenal gland and the use of adrenal hormones and their analogues; therapeutic uses of male sex hormones and the pharmacological treatment of male reproductive disorders; therapeutic uses of female sex hormones and the pharmacological treatment of female reproductive disorders; therapeutic uses of Pituitary hormones and their analogues; disorders of prolactin secretion and their treatment; disorders of growth hormone secretion and their treatment. The treatment of allergies and inflammation: the physiology of inflammation and the immune response; characteristics of inflammatory mediators; anti-inflammatory drugs; other drugs for the relief of inflammatory conditions. Applied pharmacology: basic pharmacokinetics; individual variation in drug effects; drug interactions; the placebo response. The content of this module will be delivered by way of distance learning material (80 hours) and supported by guided study (85 hours) and a residential week (35 hours). Distance learning material and accompanying provided textbooks, published reader material and reader material prepared in-house. All students have an in-house supervisor, access to company and local university libraries as well as being able to draw upon University of Brighton facilities. Examples of provided textbooks (current editions): Assessment tasks Anatomy and Physiology, Thibodeau and Patton, Mosby Human Pharmacology, Gard, Taylor and Francis Pharmacology, Rang, Dale, Ritter and Moore, Churchill Livingstone Pocket Medical Dictionary, Churchill Livingstone, Ed. Chris Brooker Written coursework (75%) and oral presentation (25%). Brief description of module content and/or aims (maximum 80 words) Area examination board to which module relates Module team/authors/ coordinator Semester offered, where appropriate Date of first approval Date of last revision Date of approval of this version Version number Replacement for previous module Course(s) for which module is acceptable and status in course School home External examiners This module aims to provide the anatomy and physiology necessary for an appreciation of the mechanisms of drug action and pharmacokinetics. The mechanisms of action and the rationale for the use of named drugs in the treatment of exemplar common diseases such as hypertension, asthma and depression is covered, and the concept of adverse drug reactions and drug interactions explained. The module also provides an introduction to the process of drug discovery, drug testing and clinical trials. n/a Prof P R Gard, Dr M Yeoman, Dr C Chatterjee, Dr A Jackson n/a February 2004 May 2003 February 2004 1 QPM03 (part), QPM04, QPM05, QPM06 PGDip/MSc Industrial Pharmaceutical Studies: compulsory Pharmacy and Biomolecular Sciences Dr S Gaisford