Download RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
KARNATAKA, BANGALORE
SYNOPSIS
BY
DR. RAHUL
Title of Topic
“A CLINICO-COMPARITIVE STUDY ON EFFECT OF GAMBHARI,
AMALAKI & HARITAKI ASCHYOTANA AND KATPHALA
ASCHYOTANA IN THE MANAGEMENT OF SHUKTHIKA W.S.R. TO
CONJUNCTIVAL XEROSIS.”
2012-2013
SHRI J.G.C.H. SOCIETY’S AYURVEDIC MEDICAL COLLEGE AND
RESEARCH CENTRE, GHATAPRABHA, BELGAUM.
FROM,
Dr. RAHUL
1st Year MS (SHALAKYA) Scholar
Post Graduate Department of Shalakya Tantra
Shri. J.G.C.H.S. AYURVEDIC MEDICAL COLLEGE, GHATAPRABHA. BELGAUM
DISTRICT
TO,
THE REGISTRAR
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCE,
BANGALORE, KARNATAKA.
THROUGH:
THE PRINCIPAL AND HEAD OF THE DEPARTMENT OF SHALAKYA TANTRA
Shri J.G.C.H.S, AYURVEDIC MEDICAL COLLEGE, GHATAPRABHA, BELGAUM.
Subject: Submission of synopsis for registration of subject for dissertation
Respected Sir,
I request you to kindly register the below mentioned subject against my name for the
submission of dissertation to RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
BANGALORE, KARNATAKA, for partial fulfillment of M.S. in SHALAKYA TANTRA.
:Title of Dissertation:
“A CLINICO-COMPARITIVE STUDY ON EFFECT OF GAMBHARI,
AMALAKI & HARITAKI ASCHYOTANA AND KATPHALA
ASCHYOTANA IN THE MANAGEMENT OF SHUKTHIKA W.S.R. TO
CONJUNCTIVAL XEROSIS.”
Here with I am enclosing completed Performa for registration of subject for dissertation.
Thanking you,
Place: Ghataprabha
Date:
Yours Sincerely
Dr. Rahul
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
KARNATAKA - BANGALORE
ANNEXURE-II
PROFORMA FOR REGISTRATION OF SUBJECT FOR
DISSERTATION
1. Name of Candidate
: Dr. RAHUL
2. Permanent Address
: HOUSE NO. S-4/87, B.B.M.B. COLONY,
SUNDERNAGAR, DISTRICT MANDI
HIMACHAL PRADESH. PIN. 174402
3. Name of Institution
: Shri J.G.C.H.S. Ayurvedic Medical College,
Ghataprabha. Belgaum District
3. Course of Study & Subject
: M.S. (Shalakya)
Ayurveda Dhanwanthari
4. Date of Admission to Centre : 11-10-2012
5. Title of the Topic:
“A CLINICO-COMPARITIVE STUDY ON EFFECT OF GAMBHARI,
AMALAKI & HARITAKI ASCHYOTANA AND KATPHALA
ASCHYOTANA IN THE MANAGEMENT OF SHUKTHIKA W.S.R. TO
CONJUNCTIVAL XEROSIS.”
6. Brief resume of the intended work
6.1 Need for the study:
The Xerosis of conjunctiva is a symptomatic condition in which conjunctiva becomes
dry, lustureless and non wettable. These patches almost always involve the inter-palpabral
area of the temporal quadrants and often nasal quadrants as well. Typical xerosis may be
associated with conjunctival thickening, wrinkling and pigmentation1.It occurs in two groups
of cases: (i) as a sequel of a local ocular affection and (ii) associated with general disease.
The first type is cicatricial degeneration of the conjunctival epithelium and glands following
trachoma, burns, diphtheria, etc. commencing in isolated spots, ultimately involving the
whole conjunctiva and cornea. Prolonged exposure due to ectropion or proptosis, where in
the eye is not properly covered by lids, also in a dry eye2. Based on a deficient serum retinol,
there are more than 125 million preschool age children with Vitamin A deficiency among
whom close to 4 million have an ocular manifestation of some kind, termed broadly as
Xerophthalmia3. Management as per modern medical science consists in relieving the dryness
with artificial tears and mucomimetic agents. In the vitamin A deficiency variety, nutrition
should be restored by administration of vitamin A2.
In children being treated
for Vitamin A deficiency according to the protocols,
transient bulging of fontanels occurs in 2% of infants and transient nausea, vomiting and head
ache occur in 5% of preschoolers. Acute toxicity of Vitamin A can result in increased
intracranial pressure, vertigo, diplopia, bulging fontanels in children, seizures and exfoliative
dermatitis, it may result in death3.
Xerosis is correlated with Shukthika as per Ayurvedic reference. In this disease, a
small elevated blackish spot resembling shell appears in shukla mandala4. Due to pitta,
blackish, grayish and yellowish spots appear in almost whole shukla mandala along with
burning sensation and pain in eyes. This is accompanied by jwara, atisara and trishna5. There
are various non invasive as well as safe treatment modalities told in Ayurvedic classics for
the treatment of Shukthika. These can be done on O.P.D. level and as well as by the patient
himself and are cheap and convenient.
Gambhari, Amalaki & Haritaki aschyotana and Katphala aschyotana are the two
medicines mentioned in Susruta Samhitha in the management of Shukthika4. Hence an
attempt will be made with such a set of simple and effective measures picked up from
Ayurvedic treatise i.e. topical instillation of Gambhari, Amalaki & Haritaki eye drops and
Katphala eye drops in Shukthika and an assessment will be made as regard to the efficacy of
both and the same will be compared in the present study.
6.2 Review of Literature:
a) Description of Shukthika Nidana and Lakshanas in Ayurveda Classics.
b) Description of Shukthika Chikitsa in Ayurveda Classics.
c) Description of Xerosis in Modern Science.
d) Description of both the Gambhari, Amalaki & Haritaki Aschyotana and Katphala
Aschyotana in Ayurvedic Literature.
Previous Work Done:
Dr. P.B.Subin – “A clinico-comparitive study on effect of internal medication of
Triphala Ghrita and Thilvaka Ghrita in the management of Shukthika w.s.r. to Bitot’s
Spots”-. 2010-11 Shri J G C H Society’s Ayurvedic Medical College and Research centre
Ghataprabha. Belgaum District
6.3 Objectives of study:
 To evaluate the efficacy of Gambhari, Amalaki & Haritaki Aschyotana in the
management of Shukthika.
 To evaluate the efficacy of Kataphala Aschyotana in the management of
Shukthika.
 To compare the efficacies of both the groups in the management of Shukthika.
7.0 Materials and Methods
Source of data:
The patients attending the OPD and IPD of Shri J.G.C.H.S.Ayurvedic Hospital,
Ghataprabha will be taken for the study.
a) Literary source:
The details of the literature of Shukthika and Xerosis will be incorporated in great
detail from the Samhitas and other Ayurvedic and Modern reference books.
b) Clinical Source:
1. Patients attending the OPD and IPD of Shri J.G.C.H.S.Ayurvedic Hospital,
Ghataprabha will be taken up for the present clinical research.
2. The patients referred from other practitioners, hospitals, institutions will also be
incorporated.
c) Drug Source:
Both the Gambhari, Amalaki & Haritaki Aschyotana and Katphala Aschyotana will be
prepared as per the guidelines given in Ayurvedic literatures in Shri J.G.C.H.S. Ayurveda
Medical College Pharmacy.
7.2 Methods of collection of data:
It is a single blind clinical study with minimum of 20 patients in each group will
be selected randomly. The clinical features will be recorded on the proforma designed for
the study.
A) Inclusive criteria:
1. The patients irrespective of age, sex, religion will be included for the study.
2. Patients with clinical features of Shukthika will be taken for study after proper
screening .
B) Exclusive criteria:
1. Patients who are on supplementation with Vitamin A.
2. Patients having any inflammatory disease of the eye.
3. Patients suffering from chronic debilitating systemic diseases.
STUDY DESIGN (INTERVENTIONS):
The screened patients of Shukthika will be randomly classified into two groups. Group
A and Group B.
Group A –
Gambhari, Amalaki and Haritaki Aschyotana will be done.
Dose – 7 or 8 drops once in a day6.
Duration – 30 days.
Group B Katphala Aschyotana will be done.
Dose – 7 or 8 drops once in a day6.
Duration – 30 days.
FOLLOW UP:
The patients of both the group will be followed up every 30 days for 2 months.
ASSESSMENT CRITERIA:
Assessment will be done on the basis of objective and subjective criteria before and
after the treatment schedule and data will be subjected to student’s paired and unpaired ‘t’
test.
SUBJECTIVE PARAMETERS:1. Dryness
2. Foreign body sensation.
3. Burning sensation.
OBJECTIVE PARAMETERS:1. Photographs.
2. Schirmer's test
3. Rose Bengal test
INVESTIGATIONS REQUIRED:
1. Schirmer's test
7.0
Does the study require any investigation or interventions to be done
on patients or other humans or animals? If so please describe
Yes. The present study requires investigations and interventions which are mentioned
above.
7.1 Has ethical clearance been obtained from your institution?
Yes. Clearance has been obtained through the ethical committee formulated in the
institution.
8. References 1. A.K. Khurana : “Comprehensive Opthamology.”
Published by New Age
International (P) Limited Publishers, Edition- 4th.
Chapter 19th - Systemic Ophthalmology, Page no 434 .
2. Parson’s Diseases of the Eye, Editors : Ramanjit Sihota and Radhika Tandon
Published by Elsevier, A division of Reed Elsevier India Private Limited, Edition- 21st
Chapter 14th – Diseases of Conjunctiva, Page no. 184.
3. Dr.Anthony S. Fauci(MD) et.al ‘Harrison’s’ Principles of internal medicine, Vol-I,
Vitamin and Trace Mineral Deficiency and Excess, Published by Mc Graw Hill
Medical New York- 2012, Edition- 18th,
Part 6, Chapter-74, PP- 601-602
4. Sushruta, ‘Sushruta Samhita’ with the Nibandhasangraha commentary by Shri.
Dalhanaacharya, Edited by Yadavji Trikamji Acharya, Chaukhamba Surbharati
Prakashan, Gopal Mandir Lane, K37/117 Varanasi, (India) Reprint : 1994, Uttara
tantra, 4thAdhyaya, Shloka no. 7. Page No. 601, 10th Adhyaya, Shloka no. 12-13. Page
No. 613
5. Vagbhata, Ashtanga Hridaya, with Vidyotini Hindi Commentary by Kaviraja
Athrideva Gupta, edited by Vaidya Yadunandana Upadhyaya, Chaukhambha
Prakashan, Reprint 2007, Uttara tantra, 10th Adhyaya, Shloka no.10-11, Page No.484.
6. Sushruta, ‘Sushruta Samhita’ with the Nibandhasangraha commentary by Shri.
Dalhanaacharya, Edited by Yadavji Trikamji Acharya, Chaukhamba Surbharati
Prakashan, Gopal Mandir Lane, K37/117 Varanasi, (India) Reprint : 1994, Uttara
tantra, 18thAdhyaya, Shloka no. 45-46. Page No. 636
9.
SIGNATURE OF THE CANDIDATE
10.
Remarks of the Guide:
11.
Names and Designation of
11.1 Guide:
11.2 Signature :
:
Dr. S. GOPAL
M.D. (SHALAKYA)
Prof. SHALAKYA TANTRA Dpt.
Shri J.G.C.H.S.Ayurvedic Medical
College Ghataprabha
Tq-Gokak, Dist-Belgaum.
Karnataka
11.3 Co-Guide :
DR. ANIL KUMAR SARANGMATH
M.S. (SHALAKYA)
Prof. SHALAKYA TANTRA Dpt.
Shri J.G.C.H.S.Ayurvedic Medical
College Ghataprabha
Tq-Gokak, Dist-Belgaum.
Karnataka
11.4 Signature :
11.5 Head of the Department
11.6 Signature
:
:
12
12.1 Remarks of Chairman
:
And Principal
12.2 Signature
:
DR. ANIL KUMAR SARANGMATH
M.S. (SHALAKYA)
Prof. SHALAKYA TANTRA Dpt.
Shri J.G.C.H.S.Ayurvedic Medical
College Ghataprabha
Tq-Gokak, Dist-Belgaum.
Karnataka