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NIAID/DMID Systems Biology for Infectious Diseases Research Valentina Di Francesco Office of Genomics and Advanced Technologies (OGAT) Division of Microbiology and Infectious Diseases NIAID, NIH, DHHS [email protected] Nov 6, 2012 Division of Microbiology and Infectious Diseases Genomics Program Sequencing Genome Sequencing Centers Functional Genomics Functional Genomics of Uncharacterized Genome regions FY13 Proteomics Structural Genomics Systems Biology Other “omics” Clinical Proteomics Centers Structural Genomics Centers Systems Biology Centers Host/Pathogen Interaction Systems Biology Human Microbiome Project Omics technologies for predictive modeling of ID - FY13 Bioinformatics Resource Centers To address key questions in microbiology and infectious disease To identify new targets and develop new strategies for vaccines, diagnostics and therapeutics DMID Systems Biology Program for Infectious Diseases Research Goal: To use a combination of computational and experimental methodologies to conduct research projects to identify, model and predict molecular interaction networks of pathogens and the host during disease infectious disease initiation and progression. Features: Integration of omics technologies Generation and sharing of experimental research data and protocols, reagents and other resources with the scientific community http://www3.niaid.nih.gov/LabsAndResources/resources/sb/programs.htm DMID Systems Biology Program A Systems Biology Approach for Infectious Diseases Research (FY08) - RFP ■ Focus on pathogen molecular interaction networks ■ BioD and EID pathogens Omics Technologies for Predictive Modeling of Infectious Diseases (FY13) – U19 “Renewal” of FY08 Initiative Focus on host-pathogen molecular interaction networks BioD and EID pathogens Emphasis on the networks modeling Introduction of a training component and of exploratory projects An Integrated Approach to Understanding Host-Pathogen Interactions (FY12) - RFP Focus on host-pathogen molecular interaction networks Pathogens causing persistent and recurrent infections Genomics Blue Ribbon Panel Report http://www.niaid.nih.gov/ topics/PathogenGenomics NIAID/DMID Blue Ribbon Panel on Genomics Recommendations for Next Decade Continue to partner with scientific community to support bioinformatics and computational infrastructure for evolving research needs. Continue to play a leadership role in data and reagents release. Set ambitious and challenging goals for applying genomic approaches to understand infectious diseases. Promote use of cutting edge genomic technologies and integrated data sets to establish new strategies for developing drugs, vaccines and diagnostics. Other Goals of the Program Multi-disciplinary research Combined multi-omics technologies Gigabytes of omics data for the broad scientific community New hypotheses generated by the systems biology approach Modeling applied to omics integrated datasets Resources for the Scientific Community Cross Center Activities • Modeling Working Group – Daniel Hyduke • Data Dissemination Working Group – Jeremy Zucker • Annual Program Meetings • 2011 Mbio “A systems biology approach to infectious diseases research, innovating the pathogen-host research paradigm” • 2013 Springer Series Book “Current topics in Microbiology and Immunology” – Michael Katze • Influenza Centers interaction & collaboration – Michael Katze and Alan Aderem