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NIAID/DMID
Systems Biology for
Infectious Diseases Research
Valentina Di Francesco
Office of Genomics and Advanced Technologies (OGAT)
Division of Microbiology and Infectious Diseases
NIAID, NIH, DHHS
[email protected]
Nov 6, 2012
Division of Microbiology and Infectious Diseases
Genomics Program
Sequencing
Genome
Sequencing
Centers
Functional
Genomics
Functional Genomics
of Uncharacterized
Genome regions FY13
Proteomics
Structural
Genomics
Systems Biology
Other “omics”
Clinical
Proteomics
Centers
Structural
Genomics
Centers
Systems
Biology
Centers
Host/Pathogen
Interaction
Systems
Biology
Human
Microbiome
Project
Omics technologies for
predictive modeling of
ID - FY13
Bioinformatics Resource Centers
To address key questions in
microbiology and infectious
disease
To identify new targets and develop
new strategies for vaccines,
diagnostics and therapeutics
DMID Systems Biology Program for
Infectious Diseases Research
Goal: To use a combination of computational and
experimental methodologies to conduct research
projects to identify, model and predict molecular
interaction networks of pathogens and the host
during disease infectious disease initiation and
progression.
Features:

Integration of omics technologies

Generation and sharing of experimental research data and
protocols, reagents and other resources with the scientific
community
http://www3.niaid.nih.gov/LabsAndResources/resources/sb/programs.htm
DMID
Systems Biology Program
A Systems Biology Approach for Infectious Diseases Research (FY08) - RFP
■ Focus on pathogen molecular interaction networks
■ BioD and EID pathogens
Omics Technologies for Predictive Modeling of Infectious Diseases (FY13) – U19
 “Renewal” of FY08 Initiative
 Focus on host-pathogen molecular interaction networks
 BioD and EID pathogens
 Emphasis on the networks modeling
 Introduction of a training component and of exploratory projects
An Integrated Approach to Understanding Host-Pathogen Interactions (FY12) - RFP
 Focus on host-pathogen molecular interaction networks
 Pathogens causing persistent and recurrent infections
Genomics Blue Ribbon Panel Report
http://www.niaid.nih.gov/ topics/PathogenGenomics
NIAID/DMID Blue Ribbon Panel on Genomics
Recommendations for Next Decade
 Continue to partner with scientific community to
support bioinformatics and computational
infrastructure for evolving research needs.
 Continue to play a leadership role in data and
reagents release.
 Set ambitious and challenging goals for applying
genomic approaches to understand infectious
diseases.
 Promote use of cutting edge genomic
technologies and integrated data sets to establish
new strategies for developing drugs, vaccines and
diagnostics.
Other Goals of the Program
 Multi-disciplinary research
 Combined multi-omics technologies
 Gigabytes of omics data for the broad
scientific community
 New hypotheses generated by the systems
biology approach
 Modeling applied to omics integrated
datasets
Resources for the
Scientific Community
Cross Center Activities
• Modeling Working Group – Daniel Hyduke
• Data Dissemination Working Group – Jeremy Zucker
• Annual Program Meetings
• 2011 Mbio “A systems biology approach to infectious
diseases research, innovating the pathogen-host
research paradigm”
• 2013 Springer Series Book “Current topics in
Microbiology and Immunology” – Michael Katze
• Influenza Centers interaction & collaboration – Michael
Katze and Alan Aderem