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CURRICULUM VITAE Tai June Yoo, M.D., Ph.D, MBA March 2013 Personal Data Date of Birth: Birth Place: Citizenship Status: Social Security Number: Marital Status: Married Number of Children: 3 March 7, 1935 Seoul, Korea U.S.A. Education 1953 1955 1959 1963 2010 Kyung-gi High School, Seoul Korea College of Liberal Arts and Sciences, Seoul National University, (1953-1955) Premedical Diploma M.D., Seoul National School of Medicine, Seoul, Korea. Ph.D. (Biophysics), University of California, Berkley, California. MBA. University of Tennessee. Postgraduate Education 1959-1961 1961-1963 1963-1964 1964-1965 1965-1966 1966-1968 1968-1969 Graduate Student and Teaching Assistant, University of California, Berkeley, California. Research Assistant, Medical Physics, University of California, Lawrence Radiation Laboratory, Berkeley, California. Intern, Medicine, Barnes Hospital, Washington University, St. Louis, Missouri. Assistant Resident, Medicine, Washington University, School of Medicine, St. Louis, Missouri. Fellow, Immunology, Washington University, School of Medicine, St. Louis, Missouri. (Mentor.C.W. Parker). Senior Cancer Research Scientist (Senior Research Fellow), Roswell Park Memorial Institute, (Mentor. D.P. Pressman) Immunology Research Department, Buffalo, New York. Associate Resident, Medicine, New York University School of Medicine, New York City, New York. (Mentor. E.C. Franklin). Academic Appointments 1960-1961 Teaching Assistant, Medical Physics, University of California, Berkeley, CA. 1 1967-1969 Research Professor, Biology, Niagara University, Niagara Falls, New York. 1972-1980 Director, Allergy/Immunology Research Laboratory, VA Medical Center, Iowa City, Iowa. 1972-1980 Director, Allergy Clinic, VA Medical Center, Iowa City, Iowa. 1972-1975 Assistant Professor, Division of Allergy/Immunology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa. 1975-1980 Associate Professor, Division of Allergy/Immunology, Department of Internal Medicine. 1975-1980 Adjunct Professor of Bioengineering, College of Engineering, University of Iowa, Iowa City, Iowa. 1980-1987 Professor of Medicine and Associate Professor of Microbiology and Immunology. University of Tennessee, Memphis, Tennessee. 1980-1981 Director of Clinical Immunology (interdivisional program. University of Tennessee, Memphis, Tennessee. 1980-Oct-2006Chief, Allergy/Clinical Immunology Section, VA Medical Center, Memphis, TN. 1980-Oct-2006Chief, Allergy Research Program, VA Medical Center, Memphis, Tennessee. 1981-1982 Acting Chief, Division of Immunology and Allergy, Department of Medicine, University of Tennessee, Memphis, Tennessee. 1981-2001 Program Director, Allergy/Clinical Immunology Training Program, Department of Medicine, University of Tennessee, Memphis, Tennessee. 1982-2007 Chief, Division of Immunology and Allergy, Department of Medicine, University of Tennessee, Memphis, Tennessee. 2007-2011 Director,Allergy/Immunology Section, Div.RheumatologyUT 1985-2011 Professor of Neuroscience program, University of Tennessee, Memphis, Tennessee. 1987-2000 Professor of Medicine and Microbiology and Immunology, University of Tennessee, Memphis, Tennessee. 2000-2011 Professor of Medicine and Molecular Sciences, University of Tennessee, Memphis, Tennessee 1/91-12/91 Visiting Associate, Department of Biology (Prof. Leroy Hood's group), California Institute of Technology, Pasadena, CA. (sabbatical leave) 1/92-7/92 Visiting Associate, Department of Biology (Prof. Leroy Hood's group), California Institute of Technology, Pasadena, CA. (Part-time) 1995-1998 Member, Biomedical Research Institute, Korea Advanced Institute of Science & Technology, DaeDuck, Korea 1995-1998 Adjunt Professor, Biological Science, Korea Advanced Institute of Science & Technology, DaeDuck, Korea 1997-2000 Adjunct Professor of Medicine, Ajou University, Suwon, Korea 2002-2011 Co-director of Research, Dept. of Otolaryngology, University of Tennessee, Memphis, Tennessee 2003-2011 Professor of Otolaryngology and Head/Neck Surgery,Univ of Tennessee,HSC 2 2009 sept-present. Changed to part time faculty member to be able to do stem cell patients work i9n Seoul(retirement and part time faculty member) 2011 December closed laboratories at UT and retired to devote 100 % of time in stem, cell therapy odf incurable illnesses in Seoul,Korea and established Stem Gen Inc. a nd ImmuGen Inc to facilitate gen evaccine work for A;lzheimer’s disease and treat incurable illnesses with autologous adipose tissue derived mesenchymal steem cells. 2010-present Director, Yoo Clinic, Seoul, Korea 2010-2012 Founder, CEO, ImmuGen.Inc 2010-2012 Founder, CEO, StemGen, Inc 2346 Wood Chapel Cove, GermanTown,Tn 2013-present, Cofounder, CMO, and CEO, Hurim Biocell America 2013 Consultant as a CMO, Hurim Medical, Seoul, Korea Other Employment Pertaining to Current Professional Appointments: 1969 - 1970 Major, U. S. Army Medical Corps, Medical Services, 121 Evac Hospital, Ascom, Korea 1970 - 1971 Lt. Col., U. S. Army Medical Corps, Chief, Department of Medicine, 121 Evac Hospital, 8th U. S. Army, Ascom Korea 1971 - 1972 Assistant Chief, Allergy/Immunology Service, Department of Medicine, Letterman General Hospital, San Francisco, CA Military Experience and Education: 1968, July 29, Commissioned as a Captain, U.S.A.R. Medical Corp. 1969, July 29, Active service as Major, Medical Corp. 1969, September, Medical staff 121st evacuation hospital (8th U.S. Army), A.P.O. San Francisco, California 1970, March, Promoted to Lt. Colonel and later became Chief, Medical Service. 1971, February, Assistant Chief, Allergy-Immunology Service Letterman Army Medical Center, Presidio of San Francisco, CA (Chief J. McGerity, Colonel M.C.). 1972, July, Discharged from active service and remained as medical staff 73rd Army Combat Suppt. Hospital, Cedar Rapid, IA. 1972-1977, Increment commander in summer annual training on an off of above unit. 3 1976-1980, Commander, 453rd Medical Detachment, Cedar Rapid, IA. 1977, July 26, Promoted to Colonel, Medical Corp. 1980-1984, Commander, 586th Medical Detachment. 1984-1986, Chief, Medical Service, 330th U.S. Army Hospital (1000 bed) 1986-9/89, Commander, Major Subordinate Command, 125 ARCOM, Memphis, TN. 1986-1/90, Commander, 330th U.S. Army Hospital (1000 bed). 1986-1/90, Commander, U.S. Army Reserve Center (No.2), Memphis, TN 1/90, Selected for the master list for General officer. 2/90, Medical Staff (Chief, Preventive Medicine) 332nd Medical Brigade, Nashville, TN. 6/90, ARCOM Surgeon, 125th Army Reserve Command, Nashville, TN. 3/95, Retired from active Army Reserve duty. Military Education: Basic Medical Officer's course, 1969, July, San Antonio, Texas. Advanced Medical Course, Ft. Sam Houston, 1985. Military personnel management course, Ft. Snelling, MN, 1975. National Defense University, 1981-1983. Commanding General and Staff College, 1985-1986. Air War College, 1987-1989. Certification and Licensure: State: Date: New York California Iowa Tennessee Hawaii 1969 1971 1972 9/9/80 (#MD12899) 1980 4 Republic of Korea 1959 (2595) Professional Affiliations (including offices held): 1966 Biophysical Society 1966 American Association for the Advancement of Sciences 1969 American Association for Immunologists 1969 New York Academy of Science 1969 American Federation for Clinical Research 1972 American Academy of Allergy 1973 Reticuloendothelial Society 1976 Central Society (as of December, 1976) 1976 American Association for Cancer Research 1976 American Society for Experimental Pathology 1982 Association of Research in Otolaryngology 1999 International Molecular Biology Network Areas of Research Interest: Mechanisms of immunotherapy of atopic disease, regulation of immune responses and tolerance to allergens. Studies and function of mite allergen, T-cell receptor repertoire with mite allergens and peptide immunotherapy of mite allergy (active). Autoimmune sensorineural hearing loss; Inner ear immunology (active). Molecular biology of collagen autoimmune injury (active). Construction of gene complexes which would produce collagen autoimmunitylike lesions and EAE lesions in transgenic mice (active). Molecular Biology of Cochlea and TCR transgene (active). Retrocochlear autoimmunity using EAE mice model (active). Oral tolerance mechanism, application for the treatment of autoimmune diseases and allergy (active). Gene therapy for atopy and autoimmune disease by naked DNA (active). Hearing study in genetically altered mice Restoration of hearing loss with tPA Development of Alzheimer’s Disease vaccine Development of new therapies and vaccines for memory loss Restoration of hearin gloss by Tcell mediated gene therapy New therapy for interstitial cystitis Stem cell therapy of Immunologic disorder, antiaging, chronic neurologic disease, esp Alzheimer’s disease 5 Current Projects: A. T-cell receptor biology/restrictive usage in autoimmunity 1. Role of T-cell receptor gene in autoimmune ear lesions (active). Identification of Vb, Va chain for CBII peptide of Type II collagen and it's fragments in autoimmune ear disease. Epitope specificity of type II collagen autoimmunity (active) Type IX and type XI collagen autoimmunity (active). Structure of TCR Va genes: promoter and recombinant signals. T-cell receptor usage, peptide therapy and oral tolerance in mite allergy. Peptide therapy for autoimmune ear disease, Meniere's disease, multiple sclerosis and house dust mite allergy. Cytokine gene activation in autoimmune disease, allergic diseases. Role of costimulatory signal in autoimmune diseases. Raf I oncogene product as an as autoantigens for autoimmune disease. 2. 3. 4. 5. T-Cell mediated gene therapy in cochlea autoimmune. Tubulin Induced Ear disease cytokine gene Rx. New therapy for interstitial cystitis ISS-ODN immunotherapy for allergic disease B. Transgenic Mice a. b. c. C. Production of transgenic mice with ear lesions and joint and brain lesions by collagen a2 (1) or (II) promoter and enhancer driven murine IFN-g, other interleukin, interleukin receptor antagonist or (2) by MBP promoter and enhancer linked with cytokine gene construct. Vb, Va and Vab TCR transgene. Histologic study of inner ear lesions in Transgenic mice (active). Molecular genetic basis of hearing loss and organ of Corti changes in mice with abnormal extracellular matrix protein gene expression. D. Ultrastructural localization of collagens Po, C-ref, Tubulins and others in the inner ear; identification of cells in the cochlea which produces these different collagens (active). E. Gene therapy (1) House dust mite and cock roach allergy with PCMV-Der PDNA; (2) Autoimmune disease, EAE, collagen autoimmune with TCRgenes (Va and Vb) insertion. (3) Alzheimer’s Disease model. (4) Cytokine DNA vaccine in Ear Disease. F .Hearing Studies in Apo-e, PAI and TPA knockout mice and genetically altered mice.g 6 G Stem cell therapy of collagen induced arthritis,autoimmune hearing loss and antiaging Hospital Appointments: Attending physician, Medical Service, 121 Army Evac Hospital, ASCOM 8th U.S. Army. APO San Francisco, CA, 1969-1971. Attending physician and consultant staff, Letterman Army Medical Center, San Francisco, CA, 1971-1972. Attending physician and consultant staff, University of Iowa Hospitals and Clinics, Iowa City, IA, 1972-1980. Attending physician and consultant staff, VA Medical Center, Iowa City, IA, 1972-1980. Attending and Consultant Staff, UT Medical Center, Memphis, TN 1980-present. Attending and Consultant Staff, City of Memphis Hospital, Memphis, TN, 1980present. Attending and Consultant Staff, Baptist Memorial Hospital, Memphis, TN 1980present. Consultant, St. Joseph's Hospital, Memphis, TN, 1983-present Consultant, Eastwood Hospital, Memphis, TN, 1983-present. Director of Allergy Clinic, VA Medical Center, Memphis, TN 1980-present. Director of Allergy Clinic, Med Plex, Memphis, TN, 1980-present. Director of Allergy Clinic, U.T. Medical Group Medicine Clinic, 1981-present. Other Professional Activities a. Boards, Editorships, etc. Reviewer: Immunochemistry Reviewer: Immunochemistry, Molecular Immunology Reviewer: Cancer Research Reviewer: Journal of Laboratory and Clinical Medicine Reviewer: Annals of Oto-Rhino-Laryngology 7 Reviewer: Allergy-Clinical Immunology Reviewer: Laryngoscope Editorial Board Annals of Oto-Rhino-Laryngology (Editor, Brain McCabe, M.D.) (Iowa City, Iowa)(1990—2004) Society of Biological Science (Washington, D.C.)(--2002) ORL (Oto-Rhino-Laryngology) (Editor, Wolfgang Arnold, M.D., Muenchen, Germany)(---2003) Journal of Biological Sciences (Washington, D.C.)(---2000) Founding Board Member Cell Therapy Research Foundation (1990-1996) b. Committees, Etc., 1. American Academy Allergy, Asthma & Clinical Immunology a. Autoimmunity committee b. Invitro committee c. Molecular Biology committee d. Allergen Standardization Committee e. Clinical Laboratory Immunology & In Vitro Tests Committee 2. Society of Biomedical Research a. Board of Directors b. Chair, long range planning committee 3. NIH Grant Reviewer, Adhoc site visitors 4. Merit Review Board for Immunology. VA Central Office. Washington, D.C. 1975-1978. 5. Search Committee Member for the Microbiology Chair. 1982-Dec 1983. 6. Department Reviewer: Department of Biotechnology, Korea. Advanced Institute of Science and Technology, Seoul, Korea, 1982. c. Consultant 1. Comprehensive Medical Diagnostic Center, Daehan Life Insurance Company, Seoul, Korea, 1989-1994. 2. Cell Biology Research Laboratory, Genetic Engineering Center, KIST & Now KRIBB, Taejon, Korea 1987-2002. 8 3. Biomedical program, Korea Advanced Institute of Science & Technology, 19952000 4. Biotechnology for Hyundai Group 1997-1998) and Sam Sung Group (1997-2000) 5. Korea Allergy Center 6. President, Immunobiotec, Memphis, TN. 1990-Present. 7. Founding board member and Vice president, Cell Therapy Research Foundation, Memphis, TN.1990-1997 8. Biomedical program, Korea Advanced Institute of Science & Technology, 19952000 9. Consultant to President, Samsung Advanced Institute of Science and Technology, 1996 – 1999 10. Consultant on Biotechnology to Vice-Chairman, Hyundai Corporation, Seoul, Korea 1996 – 1997 11. Consultant, Chairman, Korea Life Insurance Group, 1995-1995 12. Advisory Board Member: Functional genomics projects (Republic of Korea 20002010) 13. ImmuGen, founder/CEO/President 2007-present 14 Consultant, RNLBio Stem cell Reaseach Company,2008-present Honors and Awards: Korea Atomic Energy Office Post-doctoral Research Fellowship NIH Post-doctoral Fellowship Clinical Investigator Appointment (VA) 1972-1975. Armed Forces Expeditionary Medal National Defense Service Medal Armed Forces Reserve Medal Army Reserve Components Achievement Medal, Second Oak Leaf Cluster Army Service Ribbon Association of Military Surgeon of the United States Army Commendation Medal Overseas Expeditionary Ribbon Meritorious Service Medal 1990 Legion of Merit (in process) Ham Choon Alumni Award, Seoul National University, College of Medicine 1969 1969 1969 1976 1981 1986 1987 1988 1992 1997 9 (research award) Alumni Achievement Award Benefactors Society Member-University of Tennessee Il-Chun Award ,Korean Soc.of Cellular and Molecular Biology 1998 1999 1999 2005 Financial Resources (Grants) Active 1. Immune Responses in Tubulin Induced Hearing Loss in Mice. NIH Grant 2003-2009 (1 Million) Bridge fund UT, Sept 1st. 2008-August 31,2009. Stem cell therapy fund($300,000 ) 2009 Jan-Dec. Given to ImmuGen as a contract research to ImmuGen. Inc. from RNL-bio adult stem cell research company, in Seoul ,Korea 2. 3. Pending: 1. DNA vaccines for Alzheimer’s diseases(NIA.,NIH) submitted on Feb5th 2009. 2. Stem cell therapy in autoimmune hearing loss (CDMRP grant LOI sent2010) 3. Stem cell therapy for Collagen Induced arthritis in mice (CDMRPgrant LOI sent 2010) 4. Stem cell therapy for spinal cord injury in mice(DOD or CDMRPin 2010 to be sent) Pending clinical trials to be started in 2009 in Seoul,Korea. I. II. III. IV. V. VI. Stem cell therapy of Osteosrthirtis, with RNL bio’s AT-MSC in Seoul, Korea Stem cell therapy in Systemic lupus erythematosis withAT-MSC in Seoul Korea Stem cell therapy of Alzheimer’s disease with AT-Msc in Seoul, Korea Stem cell therapy on autoimmune hearin gloss and Meniere’s disease with AT-MSC inSeoul, Korea Stem cell therapy od autoimmune thyroiditis with AT-MSC in Seoul Korea Stem Cell therapy of Rheumatoid arthritis with AT-MSC in Seoul ,Korea Patents: 1. “Autoimmune inner ear disease antigen and diagnostic assay”. (U.S.Patent # 5885783 March 23 1999 10 2“Vaccine for House Dust mite allergen using naked DNA (US patent #7,439,233B1, Sept 2008 3 United States of America RESTORATION OF HEARING LOSS Granted 12/305637 2007-0619 8227437 2012-0724 4 DNA Vaccine therapy for Alzheimer’s disease. In USA, Mexico, Russia, New Zealand, South Africa.(April,2012) United States of America Mexico New Zealand Russian Federation South Africa TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES USING GENE THERAPY TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES USING GENE THERAPY TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES USING GENE THERAPY TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES USING GENE THERAPY TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES USING GENE THERAPY Granted 12/025684 2008-0204 Patent number 8247385 Granted date 2012-08-21 Granted MX/a/2009/008413 2008-0204 297495 2012-03-26 Granted 579050 2008-0204 579050 2013-01-29 Granted 2009132196 2008-0204 2471487 2013-01-10 Granted 2009/06165 2008-0204 2009/06165 2012-02-29 Patent Pending: DNA vaccine therapy of Alzheimer’s Disease ,2008 in many countries aqs follows Australia ,Canada,ChinaPR European Patent Office Israel, Philippines, India Japan, Korea, Hong Kong Post doctoral 20trainee 1. Scott Joseph, M.D., (1972-1973) Assistant Professor, Department of Medicine, Harvard Medical School 2. Dennis Rajtora, M.D. (Fellow), 1972-1974, Private Practice, (post-doc) 11 3. *Jitra Annurua, M.D. (Fellow), 1972-1974, Professor of Medicine, University of Texas, Lubbuck 4. Velijiko Zivkovich, M.D. (Fellow) 1973-1975, Private Practice 5. Al Shash, M.D. (Fellow), 1975-1976, Private Practice 6. C.Y.Kuo, Ph.D., post-doc, 1975-1977, Assistant Professor, University of Tennessee, Memphis- Now in Taiwan 7. Evans Reinders, M.D. (fellow), 1976-1978, Private Practice 8. *Arnold Katz, M.D. (Research Associate), 1976-1978, Professor and Chairman, Department. of ENT, SUNY at Stony Brook 9. John Stagner, Ph.D. 1977-1978, Research Associate 10. John Chiu, Ph.D., 1978-1980, Research Associate 11. Maurice Abbas, Ph.D. 1979-1980, Faculty member (University of Iowa) 12. Tae Wha Chang, Ph.D., 1980-1981, Director of Research, Genetics Engineering Research Institute, Dae Duck, Korea; Korea Biochemistry Society (past and present) 13. George Treadwell, M.D. (Fellow) 1980-1982, Clinical Assistant Professor, University of Tennessee 14. William McKenna, M.D. (Fellow), 1981-1983, Private Practice 15. *Koichi Tomoda, M.D. (Fellow/Japan), 1981-1983, Professor & Chairman, Department of OtoKanazava University Medical Schook, Kanazava, Japan 16. *Y. Yazawa, M.D. (Fellow/Japan), 1982-1984, Vice Chairman, Department of ENT, Shiga Medical University, Shiga, Japan 17. John Erffmeyer, M.D. (Fellow), 1980-1982, Private Practice 18. Robert Irwin, M.D. (Fellow), 1983-1984, Private Practice 19. William Grant, M.D. (Fellow), 1983-1984, Private Practice 20. Steve Orman, M.D. (Fellow), 1983-1984, Private Practice 21. Barry Feinstein, M.D. (Fellow), 1984-1985, Private Practice 22. Margaret Sweeney, M.D. (Fellow), 1984-1985, Private Practice 23. T.S. Ishibe, M.D. (Res. Assoc./Japan), 1983-1985, Clinical Assistant Professor, Kansai Medical University, Osaka, Japan 24. N.Sudo, M.D., (Research Associate/Japan), 1983-1985, Private Practice 25. *T. Takeda, M.D., (Research Associate/Japan), 1983-1985, Professor & Vice Chairman, Department ENT, Kochi Medical School, Kochi, Japan 26. *H.Y. Kim, M.D., (Visiting Scholar/Korea), 1984-1985, Professor & Chairman of Medicine, Chief, Division of Rheumatology & Immunology, Catholic Medical School, Seoul, Korea 27. *S.Y. Hue, M.D., (Visiting Prof./Korea), 1984-1985, Professor & Chairman, Department of Medicine, Choong Ang University, Seoul, Korea 28. Jay Pravda, M.D. (Fellow), 1984-1985, Private Practice 29. *I.S. Choe, Ph.D. (Research Associate), 1984-1986, Head, Molecular & Cellular Group and Deputy Director, Korea Research Institute of Bioscience and Biotechnology, Dae Duck, Korea 30. Carl M. DaCunha, M.D. (Research Associate), 1985-1986, Assistant Professor of Psychiatry, University of Tennessee, Memphis 31. *S.Y. Kim, M.D. (Visiting Scholar/Korea), 1985-1986, Director, Professor, Rheumatic Disease Center, Han Yang University Medical School, Seoul, Korea 12 32. Bruce Wolf, M.D. (Fellow), 1985-1987, Private Practice 33. *Tamutsu Harada, M.D. (Research Associate/Japan), 1985-1987, Professor & Chairman, Department of ENT, Kawasaki Medical School, Kurashiki City, Okayama, Japan 34. H. Kitano, M.D. (Research Associate/Japan). 1985-1987, Clinical Assistant Professor, Department of ENT, Shiga University Medical School, Shiga, Japan 35. *Jung Sop Song, M.D. (Research Associate/Korea), 1986-1987, Professor & Chairman of Medicine, Catholic Medical School, Yoido St. Mary's Hospital, Seoul, Korea 36. S. Ha, Ph.D. (Research Associate), 1985-1988 37. *Jae H. Kim, M.D., (1986-1987), Professor & Chairman, Department of Dermatology, Han Yang University Medical School 38. *N. Shikata, M.D. (Research Associate/Japan), 1986-1988, Associate Professor and Vice Chairman , Pathology, Kansai Medical University, Osaka, Japan 39. S. Cole, M.D., (Fellow), 1986-1988, Clinical Associate Professor, University of Tennessee, Memphis 40. B.T. Rankin, M.D., (Fellow), 1986-1988, Private Practice 41. *J.S. Lee, M.D., Ph.D. (Research Associate/Korea), 1987-1988, Professor and Chairman, Dept. of Pediatrics, Chief, Allergy/Immunology & Pulmonary, KangNam St. Mary's Hospital, Catholic Medical College, Seoul, Korea,President, Korean Academy of allergy, asthma and immununology, 42. J. Lavery, M.D., (Fellow), 1987-1989, Private Practice 43. S.H. Nam, M.D., (Research Associate/Korea), 1987-1989, Associate Professor, Chief Allergy & Immunology, Pulmonary Medicine, Hallym Medical College, Seoul, Korea-Private Practice. 44. J.W. Scott, M.D., (Fellow), 1988-1989, 45. *Jeong Saeng Cho, M.D. (Research Associate/Korea), 1988-1989, Professor & Chairman, Department of ENT, Kyang Hee University Medical School 46. Sei-Il Kim, M.D., (Research Associate/Korea), 1988-1989, Clinical Associate Professor, Catholic Medical School, Seoul, Korea 47. *Hyung-Sik Shin, M.D., (Research Associate/Korea), 1988-1989, Professor of Pathology, Chief, Surgical Pathology, Hallym University, Seoul, Korea 48. *Hiroaki Nakatani, M.D., (Research Associate/Japan), 1987-1989, Associate Professor, Department of ENT, Kochi Medical University, Kochi, Japan 49. *Yun Woo Lee, M.D., (Research Associate/Korea), 1988-1990, Professor & Chairman, Department of Medicine, Inje Medical College, Paik Hospital, Islan, Korea 50. *Hiromasa Cho, M.D., (Research Associate/China), 1990-1990, Clinical Professor, ENT Osaka City University, Osaka, Japan 51. Rosa Ong, M.D., (Research Fellow/Phillipines), 1987-1991, Research Associate, N.E.I., NIH, Bethesda, MD Now in Manila, Philipines. 52. Mi Kyung Lee, M.D., (Research Associate/Korea), 1989-1991 (Deceased) 53. Richard Kim, M.D., (Fellow) 1989-1991, Private Practice 54. Thomas Joliet, M.D., (Fellow), 1990-1991, Private Practice 13 55. *Huey Jenn Chiang, Ph.D., (Molecular Biology, Biology Division, Cal Tech), Associate Professor, Taiwan 56. Yoon S. Min, M.D., (Research Assistant, Biology Division, Cal Tech), Internist, Private Practice 57. Xi Jun Ye, M.D., (Molecular Immunology), 1987-1992), Research Assistant 58. *Tatsuya Fujiyoshi, M.D., (Autoimmunity of Cochlea), (1990-1992), Associate . Prof. of ENT, Fukuoka, Japan 59. Brian Jackson, M.D., (Fellow), 1991-1993, Private Practice 60. *Jae-Won Oh, M.D., (Research Fellow), 1992-1993, Associate Professor of Pediactrics, Han Yong University Medical Center 61. *Hyun Kyu Chang, M.D., (Research Fellow), 1993-1994, Professor of Medicine, Ulsan University Medical School, Seoul, Korea 62. James Buck, II, M.D., (Clincial Fellow), 1992-1994, Private practice 63. *Tetsuo Watanabe, M.D., (Research Fellow), 1993-1995, Assistant Professor, Oita Univ., Dept. Of Otolaryngology, Oita, Japan 64. Kumiko Watanabe, B.S. (Research Fellow), 1993-1995, Oita University, Oita, Japan 65. Kuk-Jin Song, M.D., (Research Fellow), 1994-1995, Korea Allergy Clinic 66. Yoshihiro Dake, M.D., (Research Fellow), 1994-1995 -Chief of Ent, Rail Road Hospital, Wakayama City, Japan. 67. Anjum Rana, (Clinical Fellow), 1994-1995 68. Jane Marino DePasso, M.D. (Research Fellow), 1994-1995 69. Naureen Rana, M.D., (Research Fellow), 1995-1995 70. Eun Yong Lee, M.S., Research Fellow, 1995-1995 71. James P. Clark, II, M.D., (Clinical Fellow), 1994-1996 72. Mikio Suzuki, M.D., Ph.D., 1995-1996, Professorand Chairman, Department of ENT, Ryu-kyu University Medical School, Okinawa,Japan 73. Tom Shen, M.D., 1995-1997, Private Practice 74. Kip Kim, M.D., 1996-1997, Private Practice 75. Yong Kwan Kim, M.D., PhD, 1996-1997, Private Practice 76. Hiroya Matsuoka, M.D., Ph.D.-1996-1997-Instructor, Department of ENT, Shiga University 77. J. Myeong, M. D., 1997-1998 78. Kyo-Cheol Mun, M.D., Ph.D., 1996-1998 79. Nacksung Kim, Ph.D, 1997-1999, Assistant Professor, Gene Regulation Study Center, Chun Nam National University, Korea. 80. Hiroshi Tanaka, M.D., Ph.D. 1997-1998, Instructor, Department of ENT, Shiga University 81. Naga Sambhavi Tripuraneni, Research Assistant, 1997-Housestaff 82. Sachi Signh, Research Assistant-1997 Housestaff 83. Joseph Fahhoum, M.D., Clinical Assistant Professor, 1996-1998, Univ of Tenn, Memphis 84. Soon Seog Kwon, 1997-1999, Professor, Catholic University Medical School, Korea. 85. Hyok Yop Lee, M.D. (Clinical fellow) 1997-1998, Private Practice, CaliforniaIrvine 14 86. Osman Sener, M.D., 1997-1998, Associate Professor, Turkey Military Medical University, Ankara, Turkey. 87. Figen Dogu, M.D- 1998 Sept- 1999 Jan. -Instructor, Ankara, Turkey 88. Michael Alcordo, M.D., 1999-2000, Private Practice. 89. Kyung Wha Park, M.D., Assistant Professor, Yon Sei University, Korea 90. Kyug Mi Lee, PhD 1997-1998, Research Administrator, Choong Chun Book-Do Provincial Government, Korea 91. Xiaoping Du, M.D., 1998-1999 – Research Associate, U.T.- Neurobiology 92. John Moissidis, M.D., 1999-2002 (Assistant Professor, LSU, Shervport, LA. 93. Hideo Matsuno, M. D., PhD., 1999-2000 (Research Fellow) – Assistant Professor, Kanazawa Medical University, Japan 94. J. D. Fleenor, M.D. 1999-2001 (Clinical Fellow) – Private Practice 95. Jun Yang, M.D. 2000-2002 (Clinical Fellow) – Private Practice 96. Abdelwahb Saeed, M.D. 2001-2002 – UT Research Fellow 97. Young Dae Park, M.D. 2001-2002 (Research Fellow) 98. Alan W. James – 2001-2003 – (Assistant Professor, UT) 99. Christine Michael, M.D., 2002-2004 100.Yun Kai Guo, M.D., Ph.D. 2003-2004( Associate Professor, Hunang University 101 Jae chun Lee, M.D. Med.Sc. 2004-2005 ( Assitant Professor , Jeju University 102.Mang. Ensell, Ph.D. 2004-2004 <Research associate, St.Jude Hospital 103. Jun Woo Kim,M.D.,Ph.D.Assistant prof ENT Eul-Ji Univ.2005-2006) 104 Sang soo LeeM.D.,Ph.D.,associate prof of OB-GYN, Ulsan Univ2006-2207 105 Brandon HillM.D.Clinical fellow (2004-2006)Private practice 106 John Lehman,M.D.,M.S. Clinical fellow(2005-2007)Private practice 105 Alan Redding . clinical fellow(2006-2008) Private practice 106 Mohammad Kermany,M.D.,Ph.D.(2003-2007) Research fellow..currently research fellow at SUNYAB, Hearing Research Insitute 107 Qing Cai, M.D.,M.SC.(2004-2008) Research fellow. Return to China 108 Jun Zhang, M.D.(2005-2006) Research fellow, Reetune to China 109Chun Cai,M.D.,Ph.D.(2004-2009 Feb) Research fellow , UT Physiology research Associtae,2009 March Served as Sponsor for Sabbatical Leave: 1. Thomas Budd, Ph.D., Associate Professor of Biology, St. Lawrence University, N.Y. (1980-1981) 2. T.W. Chung, Ph.D., Chief, Biotechnology Laboratory, Korea Institute of Science and Technology, Director of Research, Korea Genetic Engineering Center, Seoul, Korea. 1980-1981 3. T. Takeda, M.D., 1983, Associate Professor of Otolaryngology Kochi University Medical Sciences, Shiga, Japan, 1983-1985 15 4. S.Y. Hue, M.D., Associate Professor of Medicine, Chief, Allergy-ImmunologyPulmonary Medicine, Chung-Ang University Medical School, Seoul, Korea, 1984-985 5. H.Y. Kim, M.D., Assistant Professor of Medicine, Head, Rheumatology Division, Catholic Medical School, Seoul, Korea, 1984-1985 6. Jeanne Stutzmann, Ph.D., Associate Professor, Cell Biology, Institute de Physiologie, Strasbourg, France, 1984-1985 7. S.Y. Kim, M.D., Associate Professor, Chief, Rheumatology Division, Han Yang University Medical School, Seoul, Korea, 1984-1985 8. Koichi Tomoda, M.D. Assistant Professor of ENT, Kansai Medical University, Osaka, Japan, 1980-1983 9. Y. Yazawa, M.D. Assistant Professor of ENT, Shiga University, Otsu, Japan, 1981- 1983 10. T.S. Ishibe, M.D. Assistant Professor of ENT, Kansai Medical University, Osaka, Japan, 1981-1983 11. N. Sudo, M.D., Instructor of ENT, Kansai Medical University, Osaka, Japan, 1982-1985 12. N. Harada, M.D., Assistant Professor of ENT, Osaka University, Osaka, Japan, 1984-1986 13. H. Kitano, M.D., Associate Professor of ENT, Osaka University, Osaka, Japan, 1986-1987 14. J. Song. M.D., Associate Professor of Medicine, Head, Pulmonary Medicine, Catholic Medical School, Seoul, Korea, 1985-1987 15. N. Shikata, M.D., Assistant Professor of Pathology, Head, Autopsy Section, Kansai Medical University, Osaka Japan, 1986-1988 16. J. S. Lee, Associate Professor of Pediatrics, Head Allergy-Clinical Immunology, Catholic Medical School, Seoul, Korea, 1987-1988 17. Sei-Il Kim, M.D., Associate Professor of Gynecology, Catholic University Medical College, Seoul, Korea, 1988-1989 18. Yun Woo Lee, M.D., Instructur of Medicine, Inje Medical College Paik Hospital, Seoul, Korea, 1988-1990 16 19. H. Nakatani, M.D., Assistant Professor of ENT, Kochi Medical School, Kochi, Japan, 1987-1989 20. S.H. Nam, M.D., Assistant Professor of Medicine, Chief, Division of AllergyImmunology and Pulmonary Medicine, Hallym University, Seoul, Korea, 19871989 21. Rosa Ong, M.D., Clinical Fellow, Chinese General Hospital, Manila, Phillipines, 1988-1991 22. Hyung-Sik Shin, M.D., Assistant Professor of Pathology, Director EM Laboratory, Hallym University, Seoul, Korea, 1988-1989 23. Xi-Jun Ye, M.D., Associate Professor of Obstetrics and Gynecology, Shanghai First Medical College, People's Republic of China, 1988-1992 24. Joong Saeng Cho, M.D., Assistant Professor of ENT, Kyung Hee University, Seoul, Korea, 1988-1989 25. Hiromasa Cho, M.D., Associate Professor & Vice Chairman, Department of ENT, Osaka City University, Osaka Japan, 1/90-4/90 26. Mi Kyung Lee, M.D., Research Instructor, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, 4/89-12/91 27. Tatsuya Fujiyoshi, Assistant Professor of Medicine, Oita University Medical College, Oita, Japan, 1990-1992 28. Jae Won Oh, M.D., Chief Resident, Hanyang University Hospital, Seoul, Korea, 1991-1993 29. Hyun Kyu Chang, M.D., Korean Allergy & Asthma Clinic, Seoul, Korea, 19931994 30. Tetsuo Watanabe, Assistant Professor of Medicine, Oita University Medical College, Oita, Japan, 1992-1995 31. Kuk-Jin Song, M.D., Korean Allergy & Asthma Clinic, Seoul, Korea 1994-1995 32. Yoshihiro Dake, M.D., National Wakayama Minami Hospital, Wakayama, Japan, 1994-1995 33. Mikio Suzuki, M.D., Ph.D., Shiga University, Otsu, Japan, 1995-1996 34. H. Matusoka, M.D., Ph.D., Otsu, Japan, 1995-1996 17 35. S. S. Kwon, M.D., Associate Professor, Department of Medicine, Catholic University 36. K. C. Mun, Associate Professor, Department of BioChemistry, Key Myong University 37. H. Tanaka, M.D., Instructor, Department ENT, Shiga University 38. Osman sener,M.D. Associate professor, Turkey military medical School, 1997-98 39. Hideo Matsuno, M.D., Ph.D., Assistant Professor, Kanazawa Medical University, Kanazawa, Japan, 1999-2000 40. Yung Kai Guo, M.D., Ph.D. Associate professor of ENT., Hunang University, Chang Seu, China, 2002-2003 41. Jae Chun Lee, M.D. Assitant Professor of Medicine, Jeju university Medical school 2004-2005 42. Jun Woo Kim,M.D. Assistant Professor of Otolaryngology, ul=ji University,2006-2007 43. Sang soo Lee,M.D. Associate Professorof Obstetrics and Gynecology, Ulsan University Medical school 2006-2007. Served as a Preceptor: N.I.H. Clinical Investigator, Dr. Audrey W. Tuberville, Assistant Professor of Ophthalmology, UTCHS Dr. Arnold Katz, ENT resident, University of Iowa, Iowa City, Iowa, Grant from Milheim Foundation for Cancer Research, 1976. Presently Professor and Chairman, Department of ENT, Stony Brook, NY. Dr. Evan Reinder, Grant from Allergy and Asthma Foundation of America, 1979. Bibliography Books and/or Book Chapters 1. Yoo, T.J., Roholt, O.A., and Pressman D.: "Hapten Binding Activity in Isolated Light Polypeptide Chain from Rabbit Antibody", in The Cold Spring Harbor Symposia on Quantitative Biology, XXXII, "Antibodies", pp. 117-118, 1967. 18 2. Yoo, T.J., Florescence Probe for Antibody Active Sit, in Biochemical Fluorescence: Concepts, edited by R.F. Chen and H. Edelhoch, Vol. 2, "Dekker", Chapter 23, pp. 879-899, 1976. 3. Yoo, T.J., Kuo, C., Patil, S., Kim, U., Ackerman, L., and Cancilla, P.: Control of Oncofetal Antigen Production as an Epiphenomenon of Tumorigenesis in Tumor Associated Markers, ed. P.L. Wolf, '"Mason Publishing USA, Inc.", pp. 152-164, 1979. 4. Yoo, T.J., Kuan, K., Vestling, C.S., Kuo, C.Y., and Chiu, H.C.: The Effect of Glucocorticoids on the Production of Alphafetoprotein, Lactic Dehydrogenase and Malate Dehydrogenase in Morris Hepatoma 7777 In Vitro. In Tumor Associated Markers, ed. P.L. Wolf, "Mason Publishing USA, Inc.", pp. 145-151, 1979. 5. Yoo, T.J. and Tomoda, K.: Type II Collagen-Induced Autoimmune Salpingitis in Rats. Recent Advances in Otitis media with Effusion. B.C. Decker, Inc., p. 229232, 1984. 6. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., Ishibe, T., and Takeda, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. Proceedings of XIII World Congress of Otolaryngol., 2:1120-1121, 1985. 7. Ishibe, T., Tomoda, K., Yoo, T.J., Kang, A.H., and Cremer, M.A.: Type II Collagen in the Human and Monkey Ear. Proceedings of XIII World Congress Otolaryngol., 2:799-800, 1985. 8. Sudo, N., Tomoda, K., Floyd, R., Ishibe, T., and Yoo, T.J.: Type II CollagenInduced Autoimmune Salpingitis in the Rat. Proceedings of XIII World Congress of Otolaryngol., 2:811-812, 1985. 9. Yazawa, Y. Yoo, T.J., Ishibe, T., Tomoda, K., Floyd, R., Sudo, N., Takeda, T., and Ha, S.: Collagen-Induced Tympanosclerosis in Guinea Pig. Proceedings of XIII World Congress of Otolaryngol., 2:1122-1123, 1985. 10. Yoo, T.J., Floyd, R.A., and Kitano, H.: Animal Model of Autoimmune Ear Disease, Eds. Bernstein, J.M. and Ogra, P.L., Immunology of the Ear. 463-480, Raven Press, 1987. 11. Yoo, T.J., Yazawa, Y., Takeda, T., Sudo, N.: Immunologically Induced Temporal Bone Lesions: An Animal Model. Eds. Veldman, J.E., and McCabe, B.F. In Otoimmunology, 163-174, 1987. 19 12. Tomoda, T., Ohashi, N., Yoshie, N., and Yoo, T.J., Immunologically induced experimental hydrops. Structure and function related? Eds. Veldman, J.E. Immunobiology, Histophysiology, Tumor Immunology in Otorhinolaryngology, 123-130, Kugler, 1987. 13. Yoo, T.J., Ishibe, T., Autoimmunity of the Ear, Eds. Cruse, J.M., and Lewis, R.E., Concepts in Immunopathology: Autoimmunoregulation and Autoimmune Disease, 215-242, 1987. 14. Yoo, T.J., Autoimmune Disorders of the Cochlea, Eds: Altschuler, R.A., Bobbin, R.P., and Hoffman, D.W., Neurobiology of Hearing: The Cochlea, Raven Press, 23:425-440. 1988. 15. Kitano, H., Yoo, T.J., Production of Type II Collagen (CII) Induced Endolymphatic Hydrops (CIEH): The Effect of Local Immunization in Endolymphatic Sac (ELS), Proc. of XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, vol. 2, 2895-2898, 1991. 16. Cho, J.S., Harada, T., Kitano, H., Cho, C.K., Yoo, T.J., Effect Local Immunization of Type II Collagen, Kugler, 1991. 17. Nam, S.H., Cho, J.S., Shikata, N., and Yoo, T.J., Type IX Collagen and Immune Responses in Ear Tissues, Kugler, 1991. 18. Ong, R.C., Yoo, T.J., Jung, T.T.K., and Chiang, T.M., Activation mechanisms of platelet-activing factor in U937 cell, Kugler, 1991. 19. Yoo, T.J., Terato, K., Ye, X.J., and Seyer, J., Epitope Specificity of Type II Collagen Autoimmunity of Ear Diseases, Kugler, 1991. 20. Bernstein, J.M., Shanahan, T., Yoo, T.J., and Ye, X.J., HLA antigens and inner ear disease, Kugler Immunology & Otology, Rhinology, Laryngology, 3-11, Proc. 3rd Int. Acad. Conf. Immunobiology in Otology, Nov. 1991. 21. Yoo, T.J., Joliat, T., Krug, M., Buck, J., and Cheng, K.C., Antibodies against a 30Kd cochlear protein and types II and IX collagen in the serum of patiens with Meniere's diseases and T-cell receptor genes in collagen autoimmune ear disease, Proc. XV World Congress of ORL, Head & Neck Surgery, vol. I, p. 383-386, June, 1993. 22. Yoo, T.J., Fujiyoshi, T., and Readhead, C., Restoration of auditory evoked potential by myelin basic protein (MBP) gene therapy in shiverer mice, Proc. XV World Congress of ORL, Head & Neck Surgery, vol. I, p. 387-390, June, 1993. 20 23. Yoo, T.J., Cheng, K.C., Krug, M.S., Fujiyoshi, T., Buck, J., and Watanabe, T., Immune mechanism in type II collagen induced inner ear disease, 4th Intl. Symposium of Immunobiology in Otology, Rhinology & Laryngology, Oita, Japan, 251-255, 1994. 24. Yoo, T.J., Joliat, T., Bernstein, J., Cheng, K.C., Krug, M.S. and Fujiyoshi, T. Antibody against 30 KD cochlear protein and type IX collagen in Meniere's disease, Proceedings of the third international symposium, 1995. 25. Yoo, T.J., Fujiyoshi, T., Cheng, K.C., Krug, M.S., Kim, N.S., Lee, M.D., Shen, T., Matsuoka, H., Molecular Basis of Type II Collagen Autoimmune Ear Diseases, Annals New York Acad. Sci Immunology of ear, 830:221-235, 1997. 26. Suzuki, M., Cheng, K.C., Matsuoka, M.D., Krug, M., Bernstein, J., Yoo, T. J., The Cochlear Protein (CP) Antigens 28 KD and 30 KD and their antibodies in Meniere's Diseases, 1997. NYA Sci. Immunologic Disease of the Ear, 211220,1997. 27. Yoo, T.J., Suzuki, M., Matsuoka, H., Krug, M.S., Yazawa, Y., Cheng, K.C. Type II Collagen epitopes for autoimmune ear diseases. Proceeding of International Congress of ENT & Head, Neck Surgery 1997. 28. Cheng, K.C., Lee, K. M., Kim, K. Y., Krug, M.S., Shen, T., Yu, M.Y., Yoo, T.J., TCR in house dust mice allergy, Proceeding of International Congress of ENT & Head, Neck Surgery , 1457-1460, 1997. 29. Cheng, K. C., Suzuki, M., Matsuoka, H., Krug, M.S. Yazawa, Y., Bernstein, J., Yoo, T. J., The cochlear protein antigens in Meniere's disease, Proceeding of International Congress of ENT & Head, Neck Surgery 1095-1098, 1997. 30. Matsuoka, H., Kwon, S.S. , Yazawa, Y., Yoo, T.J., Production of endolymphatic hydrops induced by directly infusion monoclonal antibody against type II collagen CB11 peptide, 4th International symposium on Meniere’s Disease Paris, 2000: 204-214. 31. Tanaka, H., Kwon, S. S., Krug, M., Suzuki, M., Yazawa, Y., Shea, J., The ß-tubulin as an autoantigen for Meniere’s disease. Meniere’s Disease Symposium, Paris, 2000: 529-535. 32. Cheng, K.C., Matsuoka, H., Kwon, S.S., Yoo, T.J., Raf-1 protein as a potential antigen in Meniere’s disease, Meniere’s Disease Symposium,Paris, France, 2000: 1093-1098. 33. Yoo, T. J., Y. Yazawa. Immunology of Cochlear and Vestibular Disorder: In textbook of Audiological Medicine, Edited by A. Luxon. Isis Publishing, London, 2002. 21 34. Kwon, S.S., Kim, N.S., Suzuki, M., Yazawa, Y, Yoo, T.J., DNA Vaccination for The House Dust Mite Allergy: Effect of T-Cell Epitope Containing Gene Segment Vaccination, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002. 35. Cheng, K.C., Suzuki, M., Matsuoka, H., Kwon, S.S., Mora, M., Yoo, T.J., ProtoOncogene Raf-1 As An Autoantigen in Meniere’s Disease, Proceeding of Otolarynogology International Federation of Society, IFOS, In Press 2002. 36. Yoo, T.J. Suzuki, M., Kwon, S.S., Krug, M., Yazawa, Y., Tanaka, H., -Tubulin As An Autoantigen In Meniere’s Disease, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002 37. Kim, N.K., Cheng, K.C., Tanaka, H., Suzuki, M., Yazawa, Y., Mora, M., Mora, R., Mora, F., Mora, S., Yoo, T.J., Oral Tolerance of CB-11 Peptide for CollagenInduced Chondritis of Mice, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002. 38. Yoo, T.J., Shea, Jr. J., Yazawa, Y., Matsuoka, H., Tanaka, H., Suzuki, M., Mora, F., Mora, R., Mora, M., Presence of Autoantibodies in The Sera of Meniere’s Disease, Proceeding of International Federation of Otolarynogology Society IFOS, In Press 2002. 39. Suzuki, M., Kurg, M. S., Cheng, K.C., Yazawa, Y., Berstein, J., Yoo, T.J., Autoantibodies Against Inner Ear Proteins In Patients With Inner Ear Diseases, Proceeding of International Federation of Otolarynogology Society IFOS, In Press 2002. 40. Suzuki, M., Cheng, K.C., Krug, M.S., Kitanishi, T., Kouzaki, H., Nakajima, D., Sakurai, H., Yazawa, T.J., Yoo, T.J., Prevent Of Retrocochlear Hearing Loss In Murine Experimental Allergic Encephalomyelitis With T-Cell Receptor V8Specific Antibody, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002. 41. Matsuoka, H., Kwon, S.S., Suzuki, M., Kitanishi, T., Yazawa, Y., Yoo, T. J., Endolymphatic Hydrops Induced By Intracochlear Infusion Of Monoclonal Antibody Against Type II Collagen CB11 Peptide, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002. 42. Matsuoka, H., Cheng, K.C., Krug, M.S., Suzuki, M., Yoo, T.J., Murine Model Autoimmune Hearing Loss With Myelin Protein P0, In Press 2002, Proceeding of International Federation of Otolarynogology Society, IFOS, In Press 2002. 22 43. Characterization of immune response in β-tubulin induced murine autoimmune hearing loss. Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Jaechun Lee, Jun Zhang, Chun Cai, Qing Cai, Tai June Yoo. (to be published, in a 5th International Symposium of Meniere’s disease, House Clinic, LA 2005 Book In Press “Autoimmunity of Cochlea: Biology of Hearing and Hearing Loss: Molecular Mechanism of Immunologically Induced Hearing Loss: Annals Oto Rhino Larynology, supplement, edited by T.J. Yoo, St. Louis, MO-USA. Contents Preface…………………………………………T. J. Yoo/Enzo Mora Autoimmune Sensorineural Hearing Loss, Brian McCabe A Tissue Specific Approach to Gene Discovery in the Auditory System, Cynthia C. Morton, William Lambert Richardson Hearing and deafness; Molecular elements operating in the organ of Corti, Knipper Marlies and Hans-Peter Zenner Genetic Testing for Non-Syndromic Deafness, Richard JH Smith Cell Signaling in Inner Ear Immunity and Cochlear Damage, Allen F. Ryan Neuroactive Substances in Two Peripheral Nerve Fiber Systems of the Human Inner Ear: A Review, Keren Kammen-Jolly, Wei-Jia Kong, Arne W. Scholtz, Rudolf Glueckert, Mario, Bitsche, Michel Eybalin, Anneliese Schrott-Fischer Neuro-Immune Interaction in the Inner Ear: an Overview, Koichi Tomoda, MD, Yuzo Shimode, Makoto Oda, Toru Miyazawa, Masayuki Takashima In-Situ Pharmacology of The Corti’s Organ: From Animal Experiments to Clinical Applications, Jing Wang, Remy Pujol, Jean-Louis Pujol, Jean-Luc Puel Biochemistry of Inner Ear Fluid, Evelyn Ferrary Endolymphatic sac and inner ear immunity, Helge Rask-Andersen, Ulla Friberg, Birgitta Linder, Niklas Danckwardt-Lilliestrom Collagen Autoimmunity and Arthritis, Linda K. Myers and Andrew H. Kang Molecular Mechanism of Autoimmune Hearing Loss, T.J. Yoo Association of HLA-DR and Type II Collagen Autoimmunity with Meniere’s Disease, J.W. Koo, S.H. Oh, S.O Chang, M.H. Park, M.J. Lim, T.J. Yoo, C.S. Kim HLA genes and sudden sensorineural hearing loss, Sang W. Yeo, Shi-Nae Park, Kyung-Ho Park, Tai-Gyu Kim Systemic Autoimmune diseases associated with hearing loss, Alessandro Martini Audiological Findings in Autoimmune Ear Disease: Our Experience, Francesco Mora, Angelo Salami, Renzo Mora, Barbara Crippa, Marco Barbieri, Massimiliano Mora Role of Autoimmunity in Sudden loss of Vestibular Function, D. Passali, L. Salerni, G.C. Passali, R. Mora, F.M. Passali Hormonal Aspects of Meniere’s disease on the Basis of Clinical and experimental studies, Takeda T, Takeda S., Sawada S., Kakigi A. Immunologic Implications in Meniere’s disease: antibodies against p0 protein, L. Bellussi, E. Guadini, F.M. Passalis, M. Barbieris, G.C. Passali 23 68kD Autoantigen in hearing loss is not heatshock protein 70, Thomas Carey Autoimmune ear disease and anti-P0 protein antibodies, Jean-Paul Tomasi Inner Ear Antigens in diagnosis of sudden sensorineural hearing loss, D. Passali, G.C. Passali, F.M. Passali, F. Mora, L. Bellussi Proto-oncogene Raf-1 as an autoantigen in Meniere’s disease, K.C. Cheng, H. Matsuoka, M. Suzuki, R. Mora, T.J. Yoo Murine model of autoimmune hearing loss with myelin protein P0, H. Matsuoka, K.C. Cheng, Y. Yazawa, M. Suzuki, R. Mora, T.J. Yoo -Tubulin as an autoantigen for autoimmune inner ear disease, H. Tanaka, R. Mora, Y. Yazawa, M. Suzuki, T.J. Yoo Autoantibodies against inner ear proteins in patients with delayed endolymphatic hydrops and unilateral juvenile deafness, Mikio Suzuki, Masakazu Hanamitsu, Tsuyoshi Kitanishi, Hideaki Kohzaki, Hiroya Kitano Presence of autoantibodies in the sera of Meniere’s disease, T.J. Yoo, S.S. Kwon, M. Suzuki, R. Mora, K.W. Park Clinical Management of Inner Ear Diseases: Our Therapies, Renzo Mora, Francesco Mora, Andrea Barbieri, Maria Paola Cordone, Marco Barbieri Cochlear Implants in immune mediated hearing loss: Systemic Autoimmune Vasculitis Syndromes and Cochlear Implants: 4 years follow-up. Nicola Quaranta, Roberto Bartoli, Francesca Giagnotti, Antonio Quaranta Prevention of retrocochlear hearing loss in murine experimental allergic encephalitis with T cell recepto V8-specific antibody, M. Suzuki, K.C. Cheng, H. Kohzaki, R. Mora, T.J. Yoo A standardization of a “Partial Reversal Stapedotomy” technique, Ralli Giovanni, Mora Renzo, Livi Walter, Barbieri Marco, Passali Desiderio Oral administration of collagen conjugated with cholera toxin induces tolerance to type II collagen and suppresses chondritis in an animal model of autoimmune ear disease, N. S. Kim, K.C. Cheng, S.S. Kwon, R. Mora, T.J. Yoo Adoptive Cellular Gene Therapy of Autoimmune Disease – Where Rheumatology Meets Otorhinolaryngology, Ingo H. Tarner, Alenda U. Levicnik, Richard Smith, T.J. Yoo, Garry Nolan and C. Garrison Fathman (1) Papers Published or in Press 1. Yoo T.J.: X-ray Spectral Analysis of Chemical Elements in the Serum of Heritable Xanthomatosis. Ph.D. Thesis, University of California, Radiation Laboratory, UCRL, 10820, pp 1-131, 1963. 2. Yoo, T.J., Roholt O.A., and Pressman D.: Specific Binding Activity of Isolated Light Chains of Antibodies. Science 157:707-709, 1967. 3. Parker, C.W., Yoo T.J., Johnson M.C., and Godt S.M.: Fluorescent Probes for the Study of the Antibody-Hapten Reaction. I. Binding of the 5Dimethylaminonaphthalene-Sulfonamide Group by Homologous Rabbit Antibody. Biochemistry 6:3408-3416, 1967. 24 4. Yoo, T.J. and Parker, C.W.: Fluorescence Enhancement in Antibody Hapten Interaction: 1-Anilinonaphthalene-8-Sulfonate as a Fluorescent Molecular Probe for Anti-Azonaphthalene Sulfonate Antibody. Immunochemistry 5:143-513, 1968. 5. Yoo T.J., Nakamuara H., Grossberg A.L., and Pressman D.: Antibody-Ligand Interactions Studied by Fluorescence Enhancement Methods. I. Properties of the Ligand 4-Anilinonaphthalene-1-Sulfonate and 6-Anilinonaphthalene-2-Sulfonate. Immunochem. 7: 627-636, 1970. 6. Nakamura H., Yoo T.J., Grossberg A.L., and Pressman D.: Antibody-Ligand Interactions Studied by Fluorescence Enhancement Methods. II. Binding Properties of Anti-Azonaphthalene Sulfonate Antibodies. Immunochem. 7:639649, 1970. 7. Yoo, T.J.: Immunoglobulin Structure. Korean J. Intern. Med. 13:151-155, 1970. 8. Yoo T.J. and Franklin E.C.: Lack of Antibody Activity in Human Myeloma: Proteins. J. Immunol. 107: 365-367, 1971. 9. Yoo T.J.: Binding Activity of Anti-p-Azobenzene Sulfonate Antibody to 2Anilinonaphthalene-6-Sulfonate. Immunochem. 12: 205-211, 1975. 10. Yoo, T.J., Spitz E., and McGerity J.: Conifer Pollen Allergy - Studies of Immunogenicity and Cross-antigenicity of Conifer Polens in Rabbit and Man. Annals Allergy 34:87-93, 1975. 11. Yoo, T.J.: Isoelectric Distribution of Specifically Purified Rabbit Antibody Against 4-Azo-Naphthalene-1-Sulfonate. Immunochem. 12:199-204, 1975. 12. Yoo, T.J.: Hapten Binding Activity of Peptide Fragments from Purified Antibody Heavy Chain Cleaved by Cyanogen Bromide. Immunochem. 12:317, 321, 1975. 13. Yoo, T.J., Kuo, C.Y., and Stagner, J.I.: The Effect of Bordetella Pertuss Vaccine on the Growth of Hepatoma. Lancet 1:402-403, 1975. 14. Katz, A.E., Yoo, T.J., and Harker, L.A.: Serum Immunoglobulin A. (IgA) Levels in Cancer of the Head and Neck. Transactions, American Academy of Ophth. & Otolaryngology 82:131-137, 1976. 15. DeBault, L.E., Yoo, T.J., and Jensen, K.L.: Effects of Pertussis Vaccine of Cells In Vitro J. Reticuloendothel. Soc. 19:63-76, 1976. 25 16. Yoo, T.J., Kuo, C.Y., and Thompson, J.S.: A Family Study of HL-A Antigen and Ir Gene Linkage in Ragweed and Dust Allergy. Archives of Allergy and Applied Immunology, 1976. 11:89-96, 1977. 17. Yoo, T.J., Flink, R.J., Thompson, J.S., The relationship between HL-A antigens and lymphocyte response in ragweed allergy, Annals of Allergy & Clinical Immunology, St. Louis, Vol. 57 No.1, 25-28, 1976. 18. Kuo, C.Y. and Yoo, T.J.: A New Allergen from Perienteric Fluid of Ascaris suum with Respect to Charges. Internal Archives of Allergy and Applied Immunology. 54(4): 308, 1977. 19. Yoo, T.J., Kuo, C.Y., and Joseph, S.: Reaginic Immune Response to Tree Pollen Antigen in LBN Rats. International Archives of Allergy and Applied Immunology. 55:533, 1977. 20. Yoo, T.J., Kuo, C.Y., and Heath, C.: A Study of Dust-Induced Lymphocyte Blastogenesis. Acta Allergologica. 32(4):227, 1977. 21. Kuo, C.Y. and Yoo, T.J.: In Vitro Inhibition of 3H-thymidine Uptake in Morris Hepatoma Cells by Normal Rat Liver Extract: A Possible Liver Chalone. J. Natl. Cancer Inst. 56(6):1697, 1977. 22. Yoo, T.J., Kuo, C.Y., and Joseph, S.: Induction of Anti-Timothy Pollen Reaginic Antibodies and Their Cross Reactivity in the Rat. Annals of Allergy 39(4):272, October 1977. 23. Yoo, T.J., Kuo, C.Y., Rajtora, D.W., and Richerson, H.B.: Studies of Lymphocyte Stimulation Index and RAST in Symptomatic Ragweed Pollenosis. International Archives of Allergy and Applied Immunology 56:106-115, 1978. 24. Richerson, H.B., Rajtora, D.W., Penick, G.D., Yoo, T.J., Kammermeyer, J.K., and Anuras, J.S.: Late Cutaneous and Nasal Allergic Responses in Ragweed Hay Fever: Absence of Peripheral and Cutaneous Basophilia. J. All. Clin. Immunol. 64(1):67-68, 1979. 25. Wiesenfeld, M., Reinders, E., Corder, M., Yoo, T.J., Dietz, B., and Lovett, J.: Successful Retreatment with CIS-Platinum II Diamminedichloride (CPDD) After Apparent Allergic Reactions. Cancer Treatment Report 63:219-221, 1979. 26. Yoo, T.J., Kuo, C.Y., Patil, S., Kim, U., and Cancilla, P.: Loss of AlphaFetoprotein Production in Rat Hepatoma Culture Cells. Int. J. Cancer 24:184, Yoo, T.J., Kuan, K., and Vestling, C.S.: Effect of Glucocorticoids on the Production of Lactate Dehydrogenase, Malate Dehydrogenase and Alpha-Fetoprotein by Morris Hepatoma 7777 In Vitro. Biochem. Biophys. Res. Comm. 89(2): 491-496, 1976. 26 27. Katz, A.E., Yoo, T.J., Harker, L.A., and Nysather, J.O.: Serum Immunoglobulin Concentrations in Carcinoma of the Head and Neck. Prevention and Detection of Cancer, Vol. 2:p. 1335-1349, New York, 1980. 28. Yoo, T.J. and Kuo, C.: Suppression of IgE Antibody Production in Lewis Rats: Cellular and Reaginic Immune Responses to Ragweed Antigen E in Inbred Rats. Int. arch. All. & Appl. Immunology 61(3):259, 1980. 29. Reinders, E. and Yoo,,T.J.: Human Leukocyte Histamine Release Assays with Whole Ragweed and Alternaria Antigens Using Technicon Autoanalyzer II. Allergy 35:391-398, 1980. 30. Yoo, T.J., Chiu, H.C., Spector, A.A., Whiteaker, R.S., Denning, G.M., Lee, N.F.: Effect of Fatty Acid Modification of Cultured Hepatoma Cells on Susceptibility to Complement Mediated Cytolysis. Cancer Research 40:1084-1090, 1980. 31. Yoo, T.J. and Bennett, M.: Effect of Herpes simplex Virus Type 2 and Friend Erythroleukemia Virus Infection of IgE Antibody Responses to Ascaris Antigen in Mice. Int. Arch. & Appl. Immunology 65, 233-238, 1981. 32. Erffmeyer, J.E., McKenna, W.R., Lieberman, P.L., Yoo, T.J., and Taylor, W.W.: The Efficacy of Phenylephrine-Phenylpropanolamine in the Therapy of Rhinitis. Southern Med. J. 75(5):562-564, 1982. 33. Yoo, T.J., Kuo, C.Y., Spector, A.A., Denning, G., Floyd, R., Whiteaker, S., Kim, J., Kim, J., Abbas, M.k., and Budd, T.: Effect of Fatty Acid Modification of Cultured Hepatoma Cells on Susceptibility to Natural Killer Cells. Cancer Research 423:3596-3600, 1982. 34. Abbas, M.K., Yoo, T.J. and Viles, J.: Ultrastructure and Fatty Acid Modified Morris 7777 Hepatoma Cells. Cancer Research 42:4639-4649, 1982. 35. Yoo, T.J., Stuart, J.M., Kang, A.H., Townes, A.S., and Tomoda, K. and Dixit, S.: Type II Collagen Autoimmunity in Otosclerosis and Meniere's Disease. Science 217:1153-1155, 1982. 36. Budd, T.W., Kuo, C.Y., Yoo, T.J., and Cazin, J., Jr.: Antigens of Alternaria: Isolation and Partial Characterization of Basic Peptide Allergen. J. Allergy and Clin. Immunol. 71:277-282, 1983. 37. Yoo, T.J., Tomoda, K., Stuart, J.M., Kang, A.H., Townes, A.S.: Type II Collagen Induced Autoimmune Otospongiosis. Ann of Oto-Rhino-Laryng. 92(2):103108, 1983. 27 38. Yoo, T.J., Tomoda, K., Stuart, J.M., Cremer, M.A., Kang, A.H., and Townes, A.S.: Type II Collagen Induced Autoimmune Sensorineural Hearing Loss and Vestibular Dysfunction in Rats. Ann Oto. 92(3):267-271, 1983. 39. Budd, T.W., Kuo, C.Y., Cazin, J., Jr., and Yoo, T.J.L Allergens of Alternaria: Further Characterization of a Basic Allergen Fraction. Int. Arch. Allergy. Appl. Immunol. 71:83-87, 1983. 40. Yoo, T.J., Balint, J.P., Whiteaker, S., Floyd, R., and Kim, U.: Circulating Immune Complexes in Rats with Metastasizing or Non-metastasizing Mammary Tumor. Int. Arch. of Allg. & Appl. Immunol. 72:224-227, 1983. 41. Causse, J.B., Causse, J.R., Wiet, R., and Yoo, T.J.: Complication of Stapedectomies. Am. J. of Otology 4:275-280, 1983. 42. Abbas, M.K. and Yoo, T.J.: Comparison of Iodinated Antigens of Metastatic and Non-Metastatic Mammary Adenocarcinoma Cells. Int. Archives of All. & Appl. Immunol. 72:193-198, 1983. 43. Stuart, J.M., Tomoda, K., Yoo, T.J., Townes, A.S., Kang, A.H.: Serum Transfer of Collagen-Induced Arthritis. II. Identification and Localization of Autoantibody to Type II Collagen In Donor and Recipient Rats. Arthritis Rheum. 4:275-280, 1983. 44. Yoo, T.J., Yazawa, Y., Tomoda, K., and Floyd, R.A.: Type II Collagen Induced Autoimmune Endolymphatic Hydrops in Guinea Pig. Science 222:65-67, 1983. 45. Shea, J.J., Yoo, T.J., O'Connor, A.F., Tomoda, K., and Orchik, D.: Recent Advances in Meniere's Disease Research in the United States. Equilibrium Res. 42:86-100. 1983. 46. Yoo, T.J.: Etiopathogenesis of Otosclerosis: A Hypothesis. Ann of Oto-RhinoLaryng. 93:28-33, 1984. 47. Yoo, T.J., Orman, S., Shivanand, R.P., Dorminey, C., Needleman, S., Rajtora, D., Graves, N., Ackerman, L., Taylor, W.W., and Grant, W.: Evolution of Eosinophilic Leukemia with a t(5:11) Translocation in a Patient with Idiopathic Hypereosinophilic Syndrome. Cancer and Cytogenetics 11:389-394, 1984. 48. Yoo, T.J., Yazawa, Y., Floyd, R.A., and Tomoda, K.: Antibody Activity in the Perilymph from Rats with Type II Collagen-Induced Autoimmune Inner Ear Disease. Ann. of Oto-Rhino-Laryng. 93(5):1-2, 1984. 49. Yoo, T.J., Shea, J.J., Shulman, A., Per Lee, J., Gardner, G., and McCabe, B.: Autoimmune Sensorineural Hearing Loss: Treatment Update. J. Laryngol. Otol (Suppl) 19:220-227, 1984. 28 50. Yoo, T.J.: Autoimmune Sensorineural Hearing Loss-Animal Model Update and a Hypothesis of Etiopathogenesis-A Possible Tinnitus Model. J. Laryngol. Otol (Suppl) 9:205-218, 1984. 51. Floyd, R.A., Kuo, C.Y., Yoo, T.J., Song, A., Postlethwaite, A.E., and Mainardi, C.: Role of Protease Inhibitors on NK and ADCC Activities. J. Lab. Clin. Med. 103:215-222, 1984. 52. Yoo, T.J.: Etiopathogenesis of Meniere's Disease: A Hypothesis. Ann. Oto. Rhino. Laryng. (Suppl) 93(5):6-12, 1984. 53. Yoo, T.J., Tomoda, K., and Hernandez, A.: Type II Collagen-Induced Autoimmune Inner Ear Disease in the Guinea Pig. Ann. Oto. Rhino. Laryngol. (Suppl) 93(5):3-5, 1984. 54. Tomoda, K., Stuart, J.M., and Yoo, T.J.: Type II Collagen-Induced Autoimmune Salpingitis in Rats. Ann. Oto. Rhino. Laryng. 904:156-161, 1985. 55. Schiff, M. and Yoo, T.J.: Immunology of Ear Disease. Laryngoscope 95:259269, 1985. 56. Yoo, T.J., Floyd, R.A., Ishibe, T., Shea, J.J., and Bowman, C.: Immunologic Testing of Ear Disease. Am. J. Oto. 6:96-100, 1985. 57. Yoo, T.J., Floyd, R.A., Sudo, N., Ishibe, T., Takeda, T., Tomoda, K., Yazawa, Y., Stuart, J., Choe, I.S., and Ha, S.C.: Factors Influencing Collagen-Induced Autoimmune Ear Disease. Am. J Otolaryngol. 6:209-216, 1985. 58. Yazawa, Y., Yoo, T.J., Ishibe, T., and Tomoda, K.: Type II Collagen-Induced Tympanosclerosis Model in Guinea Pigs. Auris. Nasus. Larynx (Tokyo) 51975199, 1985. 59. Yoo, T.J., Sudo, N., Floyd, R., Ishibe, T., and Tomoda, K.: Type II CollagenInduced Autoimmune Salpingitis in the Rat. Auris. Nasus. Larynx (Tokyo) 51975199, 1985. 60. Yoo, T.J., Sudo, N., Tomoda, K., Yazawa, Y., Ishibe, T., Takeda, T., and Floyd, R.: Type II Collagen-Mediated Autoimmune Middle Ear Disease: Eustachian Tube Disease, otitis Media with Effusion and Tympanosclerosis. Auris. Nasus. Larynx (Tokyo) 591-593, 1985. 61. Tomoda, K., Yamashita, T., Kumazawa, Y., and Yoo, T.J.: Type II Collagen Distribution in the Middle and Inner Ear: Immunohistochemical Studies. Jpn. Ear Res. 15:119-202, 1985. 29 62. Irwin, R., Lieberman, P., Kaliner, M., Kaplan, R., Bale, G., and Yoo, T.J.: Mediator Release in Local Heat Urticaria: Protection with Combined H-1 and H2 Antagonists. J. Allergy Clin. Immunol. 76(1):35-39, 1985. 63. Yoo, T.J.: Immunologically-Induced Temporal Bone Lesion: An animal Model. In: Immunology and Immunopathology in Relation to Otology and Rhinolaryn., Kugler Pub., 147-160, 1985. 64. Yoo, T.J., Stuart, J.M., Takeda, T., Sudo, N., Floyd, R., Ishibe, T., Olson, G., Orchik, D., Shea, J. and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkeys. NY Acad Sci., 475:341-342, 1985. 65. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R., Ishibe, T., and Takeda, T.: A Guinea Pig Model of Autoimmune Endolymphatic Hydrops. NY Acad Sci., 475:343344, 1985. 66. Takeda, T., Orchik, D., Floyd, R.A., Ishibe, T., Sudo, N., Yazawa, Y., Olson, G., Shea, J.J., and Yoo, T.J.L Electrocochleographic Study of Non-human Primates with Collagen-Induced Ear Disease. Proceedings of XIII World Congress of Otolaryngol, 2:1114-1115, 1985. 67. Yoo, T.J.: Autoimmune Diseases of the Cochlea. In: Neurobiology of Hearing: The Cochlea. Raven Press, Eds.: Hoffman, D.W., Hetschuler, R.A. and Bobbin, R.P., 425-440, 1986. 68. Sudo, N. and Yoo, T.J. Effects of Anti-inflammatory Drugs on Collagen Induced Autoimmune Ear Disease. Annals Oto Rhino Larynx, 1987. 69. Yoo, T.J., Floyd, R.A., Shea, J.J. Enchondral Cartilage Vests Collagens Autoimmunity as a Pathogenetic Mechanism of Otosclerosis. Am J. Otolaryng, 8:317-324, 1987. 70. Yoo, T.J., Chiang, T., Dixit, S., Sudo, N., Takeda, T., Ishibe, T., Seyer, J. Shea, J.J., Causse, J.B., Causse, J. Collagen Components of Bovine Fetal and Guinea Pig Cochlear Bone and Human Stapes. Annals Oto Rhino Laryn, 97:3:318-321, 1988. 71. Sudo, N., Yoo, T.J., Effect of Anti-Inflammatory Drugs on Collagen-Induced Autoimmune Inner Ear Disease, Ann. Oto. Rhin. & Laryn. 97:2:153-158, 1988. 72. Yoo, T.J., Kim, S.Y., Stuart, J.M., Floyd, R.A., Olson, G.A., Cremer, M.A. and Kang, A.H., Induction of Arthritis in Monkeys by Immunization with Type II Collagen, J. Exp. Med. 168:777-782, 1988. 73. Kitano, H., Takeda, T., Chiang, T.M., and Yoo, T.J., Prostaglandins in Type II Collagen-Induced Ear Diseases, Amer. J. Oto. 9:6:465-469, 1988. 30 74. Yoo, T.J., and Tomoda, K., Type II Collagen Distribution in Rodents, Laryngoscope 98:11:1255-1260, 1988. 75. Yoo, T.J., Kim, S.Y., Stuart, J.M., Floyd, R.A., Olson, G.A., Cremer, M.A., and Kang, A.H., Induction of Arthritis in Monkeys by Immunization with Type II Collagen. J. Exp. Med. 168:777-782, 1988. 76. Kitano, H., Yoo, T.J., The Effect of Local Immunization in Endolymphatic Sac on the Production of Type II Collagen (cII) Induced Endolymphatic Hydrops, Ear Res. Jpn. 19:381-384, 1988. 77. Ishibe, T., Choe, I.S., Yoo, T.J., Type II Collagen Distribution in the Ear of the Developing Chick Embryo, Laryngoscope 99:5:547-552, 1989. 78. Ishibe, T., Cremer, M.A., Yoo, T.J., Type II Collagen Distribution in the Ear of the Developing Guinea Pig Fetus, Ann. of Otol. Rhin. & Laryn. 98:8:648-654, 1989. 79. Ishibe, T. and Yoo, T.J. Type II Collagen Distribution in the Monkey Ear: Amer. J. Otol., 11:1, January, 1990. 80. Lee, J.S., Ong, R., Yoo, T.J., Chiang, T., Binding of Platelet Activating Factor by Isolated Membrane from U937 Cells: Cell. Immun., 125:415-425, 1990. 81. Ye, X.J., Terato, K., Nakatani, H., Cremer, M., and Yoo, T.J., Monoclonal Antibodies Against Bovine Type IX Collagen (LMW Fragment): Production, Characterization, and Use for Immunohistochemical Localization Studies, J. Histo. & Cytochem. vol. 39 #3, p. 265-271., 1991. 82. Cho, H., Yamada, Y., Yoo, T.J., Ultrastructural changes of cochlea in mice with hereditary chondrodysplasia (cho/cho). Genetics of Hearing Impairment, NY Acad. Sci., 630, 259-261, 1991. 83. Yoo, T.J., Shulman, A., Brummett, R.E., Griest, S.E., Mulkey, M., and Rubenstein, M., Specific Etiologies of Tinnitus, book chapter, Tinnitus Diagnosis/Treatment, Shulman, et al., Lea & Febiger, 1991. 84. Cho, H., Buchanan, J., Yamada, Y., Strong, D., Yoo, T.J., The molecular and structural basis of hearing impairment in mice with the creatine phosphokinase mutant gene. Genetics of Hearing Impairment, vol. 630 p.262-264 NY Acad. Sci., 1991. 85. Yoo, T.J., Cho, H., Yamada, Y., Hearing impairment in cmd/cmd (cartilage matrix deficiency) mutant mice. Genetics of Hearing Impairment, vol. 630 p.265267 NY Acad. Sci., 1991. 31 86. Ong, R.C., Yoo, T.J., Chiang, T.M., Activation Mechanism of Platelet-Activating Factor in U937 Cell: Possible Involvement of Protein Kinase C+, Cell Immunol. 137, 283-291, 1991. 87. Slepecky, NB., Savage, J.E., and Yoo, T.J., Localization of type II, IX and V collagen in the inner ear, Acta Otol.,112:611-617, 1992. 88. Slepecky, N.B., Cefaratti, L.K., and Yoo, T.J., Type II and Type IX collagen from heterotypic fibers in the tectorial membrane of the inner ear, Matrix 11:8086,1992. 89. Slepecky, N.B., Savage, J.E., Cefaratti, L.K., and Yoo, T.J., Electron microscopic localization of type II, IX and V collagen in the organ of Corti of the Gerbil, Cell & Tiss. Res. 267:413-418, 1992. 90. Yoo, T.J., The study of collagens and transgenic mice models for ear disease, book chapter, The Korean Otologic Study Group Journal, vol. 2, #1, p. 18-23. 1991. 91. Yoo, T.J., T Cell receptor repertoire and type II collagen autoimmune ear disease, book chapter, The Korean Otologic Study Group Journal, vol. 2, #1, p. 33-46. 1991. 92. Law, P.K., Goodwin, T.G., Fang, Q., Duggirala, V., Florendo, J.A., Kirby, D.S., Deering, M.B., Li, H.J., Chen, M., Yoo, T.J., Cornett, J., Li, L.M., Holcomb, R.L., Long-term improvement in muscle function structure and biochemistry following myoblast transfer in DMD. Acta Cardiomiologica 3:281301, 1991. 93. Law, P.K., Yoo, T.J., et al., Feasibility, safety and efficacy of myoblast transfer therapy on duchenne muscular dystrophy boys, Cell Transplantation, vol. 1, 235244, 1992. 94. Joliat, T., Seyer, J., Bernstein, J., Shaw, J., Krug, M.S., and Yoo, T.J., Antibodies against a 30Kd Cochlear Protein and Types II and IX collagen in the serum of patients with inner ear diseases, Annals of Otol. Rhinol. & Laryngol. vol. 101 #12, 1000-1006. 1992. 95. Law, P.K., Goodwin, T.G., Fang, Q., Deering, M.B., Duggirala, V., Larkin, C., Florendo, J.A., Kirby, D.S., Li, H.J., Chen, M., Cornett, J., Li, L.M., Shirzad, A., Quinley, T., Yoo, T.J., and Holcomb, R., Cell transplantation as an experimental treatment for duchenne muscular dystrophy, Cell Transplantation, vol. 2, 001-021, 1993. 32 96. Hahm, JS, Kim, SY, Kim, MH, Kim, TY, Chang, SY, Choe, IS, and Yoo, TJ, Transfer Factor Treatment in Patients with HBsAg-Positive Chronic Active Hepatitis, Korean J BRM: 3:2, 197-205, 1993. 97. Dykowicz, M.S., Kim, H.W., Orfan, N., Yoo, T.J., Lieberman, P., Immunologic analysis of anaphylaxis to protamine component in NPH human insulin. J. of Allergy & Clinical Immunology, 93:117-125, 1994. 98. Yoo, T.J., Lee, M.K., Min, Y.S., Chiang, H.J., Wang, K., Fujiyoshi, T., Watanabe, T., Krug, M.S., Seyer, J., Cheng, K.C., "Epitope Specificity and T-cell receptor Usage in Type II Collagen Induced Autoimmune Ear Disease, Cellular Immunology 157:249-262, 1994. 99. Fujiyoshi, T., Hood, L., Yoo, T.J., Restoration of Brainstem Auditory evoked potentials by gene transfer in shiverer mice, Annals of OtoRhinoLaryngology, 103:6 449-456, 1994. 100. Khetarpal, U., Robertson, N.G., Yoo, T.J., Morton, C.C., Expression and Localization of COL2A1 mRNA and Type II Collagen in Human Fetal Cochlea, Hearing Research, 79:59-73, 1994. 101. Wang, K., Kuo, C.L., Cheng, K.C., Lee, M.K., Yoo, T.J., and Hood, L.E., Structural analysis of mouse T-cell receptor Va2 subfamily, Immunogenetics, 40, 116-122, 1994. 102. Chang, H.K., Song, K.J, Yoon, H.J., Cheng, K.C., Yoo, T.J., Characteristics of latex protein and the prevalence of latex allergy, J. Korean Society of Allergology, 15:4 629-631, 12/95. 103. Cheng, K.C., Chiang, H.J., Wang, K., Lee M.K., Yoo, T.J., and Hood, L., Dominant usage of T-cell receptor alpha gene segments from one parent in experimental autoimmune encephalomyelitis induced in F1 mice, Ann. NY Acad. Sci, 756:329-330, 1995. 104. Yoo, T.J., Lee, M.K., Min, Y.S., Chiang, H.J., Wang, K., Fujiyoshi, T., Krug, M.S., Seyer, J., Cheng, K.C., Comparison of epitopes specificity and T cell receptor usage in response to type II collagen immuniation between H-2q and H2r mice, Ann. N.Y Acad. Sci, 756:215-216, 1995. 105. Law, P.K., Goodwin, T.G., Fang, Q., Deering, M.B., Duggirala, V., Larkin, C., R.L., Myoblast Transfer: Gene Therapy for Muscular Dystrophy, Gene Therapy & Molecular Medicine, J. of Cellular Biochemistry, Supp. 21A, 356, 1995. 106. Takeda, T., Sudo, N., Kitano, H., and Yoo, T.J., Type II Collagen Induced Autoimmune Ear Disease in Mice, Amer. J. of Otology, 17:69-75, 1996. 33 107. Ye, X.J., Marion, T.N., Terato, K., Tillman, D.M., and Yoo, T.J., V-region DNA Sequences of Anti-type II collagen antibodies which induce relapsing polychondritis in mice, Clinical Immunology and Immunopathology, Clin. Immun. & Immunopath. 78:3:263-275, 1996. 108. Watanabe, T., Cheng, K.C., Krug, M.S., and Yoo, T.J., Brainstem Auditory evoked potentials (BAEPs) on EAE mice, Annals of Otology, Rhinology and Laryngology, 105:905-915, 1996. 109. Fujiyoshi, T., Cheng, K.C., Krug, M., Yoo, T.J., Molecular Basis of Type II Collagen Autoimmune Disease: Observations of Arthritis, Auricular Chondritis and Tympanitis in Mice, ORL (Otorhinolaryngology) 1997; 59:215-229. 110. Suzuki, M., Krug, M.S., Cheng, K.C., Yazawa, Y., Yoo, T.J., Antibodies against Inner-Ear Proteins in the Sera of Patients with Inner-Ear Diseases. ORL., 59:1017, 1997. 111. Suzuki, M., Cheng, K.C., Krug, M.S., and Yoo, T. J., Successful prevention ofretrocochlear hearing loss in murine experimental allergic encephalitis with T cell receptor VB8 specific. Antibody, Annals of Otology, Rhinology Laryngology, in Press 1998. 112. Cheng. K.C., Krug, M.S., Watanabe, T., Suzuki, Mi., Choe, I.S., Yoo, T.J., House dust Mite induced allergic Sensitivity in Mice, 101: 51-59 JACI, 1998. 113. “Tcra-V and Tcra-J gene usage in MBP responding T cells from (B10.PLxPL/J) F1 mice is based toward that of B10.PL mice,” Cheng, K.C., Chiang, H. J., Wang, K., Krug, M. S., Yoo, T. J. And Hood, L. J of Neuroimmunology, 80; 13-22 (1997). 114. Cheng, K.C., Lee, K.M., and Yoo, T.J., Restrictive TCRV V8S2 gene segment usage in the cochlear lesion of EAE mice, ORL, Vol 108, No. 60: 126-132 March, 1998. 115. Matsuoka, M., Cheng, K.C., and Yoo, T.J., Autoimmune hearing loss in mice induced by myelin PO protein, Annal of Otology, Rhinology & Laryngology, In Press, Vol 8- No. 3: page 255-264- March 1999. 116. Cheng, K.C., Lee, K.M., Kwon, S. S., Yazawa, Y., Matsuoka, H., Mora, M. and Yoo, T. J., Proto-Oncogene Raf-1 As An Autoantigen In Meniere’s Disease, Annals of Oto Rhin Laryn , Vol 109, No. 12: 1093-1098 December 2000. 117. Kim, Nacksung, Kuang Chuan Cheng, and Tai-June Yoo, Oral administration in the CB11-induced tolerance in chondritis in Mice, Annals of Oto Rhin Laryn, 2001: Vol 110: 646-654. 34 118. S.S. Kwon, N. Kim, T.J. Yoo, The effect of vaccination with DNA encoding murine T-cell epitopes on the Der p 1 and 2 induced immunologlobulin E synthesis, Allergy Journal, 2001: Vol 56: 741-748. 119. Yoo, T. J., Sener, Osman, Kwon, S.S., Xianxi Ge, Shea, John J. The presence of autoantibodies in the sera of Menier’s disease. Annals of Oto Rhin Laryn, Vol 110 No. 5: 425-429 May, 2001. 120. Yoo, T.J., Molecular mechanism of experimental Autoimmune hearing in animal, Acta Otolaryngologica suppl., 548:3-9 2002. 121. Matsuoka, Hiroshi, Kwon, Soon Seog, Yazawa, Yoshiro & Yoo, T.J., Introduction of endolymphatic hydrops induced by directly infusion monoclonal antibody against type II collagen CB11 peptide. Annals of Oto Rhin Laryn, Vol III:587-592 2002. 122. Du, X, S.S., Tai June Yoo. Immunohistochemical localization of beta-tubulin in guinea pig inner ORL, 2003; 65:7-16. 123. Mora, R., Barbieri, M., Mora, F., Crippa, B., Mora, M., Yoo, T.J., Intravenous infusion of recombinant tissue plasmingen activator (rtPA) for the treatment of Patients with sudden hearing loss and/or chronic hearing loss, Annals Oto Rhino Laryn, 2003:112:665-670. 124. Mora, R., Mora, F., Chiarlone, M., Mora, M., Barbieri, M., Yoo, T.J., Restoration of hearing loss with tissue plasminogen activator, Annals Oto Rhino Laryn, 2003: 112:671-674. 125. Du, X., Mora, R., Barbieri, M., Yoo, T.J., TUNEL-positive labeling in mouse inner ear caused by tubulin immunization is not apoptosis, ORL, 2003;17-21. 126. Tarner IH, Levicnik AU, Smith R, Yoo TH, Adoptive Cellular Gene Therapy of Autoimmune Disease - Where Rheumatology Meets Otorhinolaryngology; Annals Oto Rhinol Laryngol, Supplement of Meeting Proceedings; Genoa, Italy, T.J. Yoo – Editor, In Press. 2003. 127. Sener, Osman, T.J. Yoo, Yong-Kwan Kim, Mehmet Karaayvaz, Nejat Ozanguc, Tai June Yoo. Comparison of the skin test to aeroallergens in Ankara and Seoul. Journal of Investigational Allergy & Clinical Immunology, 2003: 13(3):202-8. 128. Koo JW, Oh SH, Chang SO, Park MH, Lim MJ, Yoo T.J., Kim CS. Association of HLA-DR and Type II Collagen Autoimmunity with Meniere’s Disease, Tissue Antigens 2003: 61:99-103. 35 129. Kwon, S.S., Nacksung Kim, Chiang Wang, Xiaoping Du, and Tai-June Yoo, Vaccination with DNA encoding T cell epitopes suppresses on the Der p induced IgE production. Journal of Asthma 2005 42 (2) 119-250 130. Morphological and Functional Alterations of the Cochlea in Apolipoprotein E Gene Deficient Mice Yunkai Guo, Chunxiang Zhang, Xiaoping Du, Usha Nair, Tai June Yoo Hearing Research 2005 208 (1-2) 54-67 131. Kim, Nacksung, S.S. Kwon, and T.J. Yoo, Protective effectof the allergen induced immunologlobulin E production by the naked DNA J. Korean Med Science 2005 20 765-71 132. Interstitial Cystitis Successfully Treated by Anti I gE Therapy. Intern Journal of Urology Jaechun Lee, Ragi Doggweiler-Wiygul, Sohyung Kim, D. Hill, T.J. Yoo 133. Allertic rhinitis Evaluation of prick test postivity for German and American cockroaches. Barbieri M. Salami A. Cordone G. Sovatzis A. Cordone MP, Mora R, T.J. Yoo Acta Otohinolaryngol Ital 2002 Jun 22 (3) 150-2 134. Induction of hearing loss in mice with β -tubulin immunization JunWoo Kim, Patrick Kim, Tai June Yoo in Proceeding of International symposium of Meniere’s Disease. 135 Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy. Kim N, Lee J, Kim S, Yoo TJ… Clin Mol Allergy 2006 Feb 20;4:4 136 Identification of 17 Hearing Impaired Mouse Strains in the TMGC ENUMutagenesis Screen. Mohammad Habiby Kermany, Lisan L. Parker, Yun-Kai Guo, Darla Miller, Douglas J. Swanson, Tai-June Yoo, Dan Goldowitz, Jian Zuo, Division of Allergy/Immunology, Department of Medicine, University of Tennessee, Memphis, TN, USA.Hear Res. 2006 Oct;220(1-2):76-86 137 Impaired Stria Vascularis in the Inner Ear of Apolipoprotein E gene knockout mice Zhu,S.,Du,X.,Cai,Q,Guo,Y,Liu,L.,Cheng,W.,Tao,,Z.,Yoo,T. ORL,70(6)373380,2008 138 Induction of Tolerance by Oral Administration of Beta-Tubulin in an Animal Model of Autoimmune Inner Ear Disease. Qing Cai, Xiaoping Du, Bin Zhou, Chun Cai, Mohammad Habiby Kermany, Taijune Yoo. ORL 2009;71:135-141. 139 ENU induced single mutation locus on chr16 leads to high-frequency hearing loss in mice. Yan Jiao, Chun Cai, Mohammad Habiby Kermany, Jian Yan, Qing Cai, Darla Miller, Daniel Goldowitz, Xinmin Li, Tai-June Yoo, Weikuan Gu. Genes Genetic. Syst. 2009; 84:219-224 36 140 Effects of Simvastatin on Plasma Lipoproteins and Hearing Loss in Apolipoprotein E Gene Deficient Mice. Qing Cai, Xiaoping Du, Bin Zhou, Chun Cai, Mohammad Habiby Kermany, Taijune Yoo. ORL 2009;71:244-250. 141 Zhou B, Kermany MH, Glickstein J, Cai Q, Cai C, Zhou Y, et al. Murine autoimmune hearing loss mediated by CD4(+) T cells specific for β-tubulin. Clin Immunol. 2011 Feb;138(2):222-30. 142 Zhou, Yixuan; Yuan, Jingdong; Zhou, Bin; Lee, Austin; Lee, Albert; Ghawji, Maher; Yoo, Tai. The therapeutic efficacy of human adipose tissue-derived mesenchymal stem cells on experimental autoimmune hearing loss in mice. Immunology. 2011 May;133(1):133-40. 143 B. Zhou, M. Ensel, Y. Zhou, U. Nair1, J. Glickstein, M. H. Kermany, Q. Cai1, C. Cai, W. Liu,Y.-P. Deng, A. Kakigi, M. Barbieri, M. Mora, S. Kanangat & T. J. Yoo .Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation. Allergy 2011; 144 Bin Zhou, Jingdong Yuan, Yixuan Zhou, Maher Ghawji Jr., Yun-Ping Deng , Austin J. Lee, Albert J. Lee , Usha Nair ,Andrew H. Kang, David D. Brand, Tai June Yoo .Administering human adipose-derived Mesenchymal stem cells to prevent and treat experimental arthritis Clinical Immunology (2011) 141, 328– 337 145 Yixuan Zhou, Jingdong Yuan, Bin Zhou,1 Austin J. Lee, Albert J. Lee, Maher Ghawji Jr and Tai June Yoo The therapeutic efficacy of human adipose tissue derived mesenchymal stem cells on experimentalhearing loss in mice. Immunology 2011 146 Bin Zhou, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Yixuan Zhou, Usha Nair, Wenxia Liu, Tai June Yoo, Experimental autoimmune hearing loss is exacerbated in IL-10-deficient mice and reversed by IL-10 gene transfer. Gene Therapy (2012) 19, 228–235 1.Tomoda, K., and Yoo, T.J. Type II Collagen Distribution in Human Ear. (Revision) 2.Takeda, T. Orchik, D. and Yoo, T.J. Type II Collagen-Induced Autoimmune Sensorineural Hearing Loss in Non-Human Primates, Submitted. (Revision). 3Clark, J.P. II, Shen T.J., Fahhoum, J., Watanabee, T., Yoo, T.J., and Cheng, K.C., Immune responses to crude house dust mite and immunodominant peptide in a murine model. (Revision) 1. Shen, T.J., Fahhoum, J., Matsuoka, H., Yoo T.J., and Cheng, K.C., High dosage of epitope peptide sensitization tolerize HDM specific IgE production in HDM sensitized Mice. (Revision) 37 2. Induction of hearing loss with different doses of tubulin in mice Mohammad Habiby Kermany, MD. Ph.D; Xiaoping Du, MD; Bin Zuo, MD; Tai June Yoo, MD. ) Bin Zhou, Mohammad Habiby Kermany, Chun Cai, Qing Cai, Jonathan Glickstein, Tai June Yoo. Adoptive immunotherapy of experimental autoimmune hearing loss via T cell delivery of the IL-12 p40 subunit. (In preparation) 3. Mohammad Habiby Kermany, Bin Zhou, Qing Cai, Cai Chun, Junwoo Kim, Tai June Yoo. Hearing loss in Amyloid precursor protein (APP) transgenic mouse. ORL. (In preparation) 4. , (3) Abstracts : 1. Yoo, T.J. and Park, C.W. Spectrofluorometric Studies in Hapten-Antibody Interaction. Biophys. J. 6:78, 1966. 2. Yoo, T.J. and Pressman, D.L Hapten Binding Activity of Peptide Fragments from Purified Heavy Chain Cleaved By Cyanogen Bromide. Fed. Proc. 27:683, 1968. 3. Yoo,T.J.: Isoelectric Distribution of Antiazonaphthalene Antibody in Rabbit.Fed.Proc.32:958, 1973. 4. Yoo, T.J., Spitz, E. and McGerity, J.: Immunogenicity and Cross Antigenicity of Juniper Pollen. International Congress of Allergology, Tokyo, Japan, 1973. 5. DeBault, L.E. and Yoo, T.J.: A Study of Interaction of a Hydrophobic Fluorescence Probe, 4-Anilino-Naphthalene-1-Sulfonate (4, 1-ANS), with Immunocompetent Spleen Cells and Tissue Culture Cells. 13th Annual Meeting of American Society for Cell Biology, 1973. 6. Yoo, T.J. and DeBault, L.E.: A Study of Interaction of a Fluorescence Probe, 4AnilinoNaphthalene-1-Sulfonate (4,1-ANS), with Immunocompetent Cells. Reticuloendothelial Society Meeting, 1973. 7. Yoo, T.J. and Nysather, J.: Reaginic Immune Response to Naphthalene Sulfonate in Rabbit and Rat. American Academy of Allergy, 1974. 8. Yoo, T.J., Spitz, E., and McGerity, J.: Allergy to Cuppressaceae Pollen. American Academy of Allergy, 1974. 9. Yoo, T.J.: Genetic Control of Reaginic Immune Response in Rat. Fed. Proc. 33:774, 1974. 10. DeBault, L.E. and Yoo, T.J.: Acute Effects of Bordetella Pertussis Vaccine on the Surface Cytomorphology of Cells in Culture. 14th Annual Meeting of American Society of Cell Biology, 1974. 11. DeBault, L.E., Yoo, T.J., and Burns, C.P.: Loss of Surface Microvilli and Cell Death Induced by Bordetella Pertussis Vaccine. Reticuloendothelial Society Meeting, 974. 12. Joseph, S., Kuo, C.Y., and Yoo, T.J.: Reaginic Immune Response to Early and Late Tree Pollen in LBN Rats. American Academy of Allergy, 1975. 13. Yoo, T.J., Flink, R., and Thompson, J.S.: The Relationship Between HL-A Antigens and Lymphocyte Response in Ragweed Allergy. American Academy of Allergy, 1975. 38 14. Yoo, T.J.: A Study of Microspecificity of an IgE Antibody Active Site. Fed. Proc. 34:1000, 1975. 15. Joseph, S., Kuo, C.Y., and Yoo, T.J.: Induction of Anti-Timothy Pollen Reaginic Antibodies and their Cross Reactivity. Fed. Proc. 34:983, 1975. 16. Stagner, J.I. and Yoo, T.J.: The Effect of Bordetella Vaccine on the Growth of Hepatoma. Fed. Proc. 34:852, 1975. 17. DeBault, L.E. and Yoo, T.J.: Acute Effects of Bordetella Pertussis Vaccine on Cells in Culture: A Time Lapse LM and SEM Study. Fed. Proc. 34:858, 1975. 18. Kuo, C.Y., Yoo, T.J., Rajtora, S.W., and Richerson, H.B.: Radio-Allergo-Sorbent Test (RAST) and Lymphocyte Stimulation Index (LSI) as Predictors of Ragweed Pollenosis Symptomatology. Am. Acad. Allergy, 1976. 19. Yoo, T.J., Kuo, C.Y., Thompson, J.S., Flink, R., Easter, C., and Schindler, F.: A Family Study of HL-A Antigen and Ir Gene-Linkage in Ragweed and Dust Allergy. Am. Acad. Allergy, 1976. 20. Heath, C., Schindler, F., Kuo, C.Y. and Yoo, T.J.L Lymphocyte Stimulation Study in Dust Allergy Patients. Am. Acad. Allergy, 1976. 21. Yoo, T.J., and Kuo, C.Y.L The Effect of Allergenic Stimulation on the Growth of Rat Hepatoma. Am. Assoc. Cancer Res. 17:197, 1976. 22. Kuo, C.Y., Preece, A.W., and Yoo, T.J.: Growth of Rat Hepatoma Effect of Preimmunization of Tumor Antigen and Tumor Cell. Fed. Proc. 35:225, 1976. 23. Yoo, T.J., Kuo, C.Y., Thompson, J.A., Flink, R., Easter, C., and Schindler, F.: A Family of HL-A Antigen and Ir Gene Linkage in Ragweed and Dust Allergy. Fed. Proc. 35:713, 1976. 24. Katz, A.E., Yoo, T.J., Harker, L.A., and Nysather, J.O.: Serum Immunoglobulin Concentrations in Carcinoma of the Head and Neck. Third International Symposium of Detection and Prevention of Cancer, New York, New York, April, 1976. 25. Yoo, T.J., Kuo, C.Y., and Thompson, J.S.: A Family Study of HL-A Antigen and Ir Gene Linkage in Ragweed and Dust Allergy. Submitted to First International Symposium on HL-A and Disease, June 23, 1976, Paris, France. 26. Kuo, C.Y., Cheng, R.F., and Yoo, T.J.: In Vitro Inhibition of 3H-Thymidine Uptake in Morris Hepatoma Cells by Normal Rat Liver Extract A Possible Liver Chalone. Submitted, American Association of Experimental Pathology, 1976. 27. Kuo, C.Y., Dryer, C., Schneider, T., Sulzabach, P., and Yoo, T.J.: Cellular and Reaginic Immune Responses to Ragweed Antigen E (AgE) in Inbred Rats. Am. Acad. Allergy and Immunol., 1976. 28. Richerson, H.B., Rajtora, D.W., Kammermeyer, J.K., and Yoo, T.J.: Studies of Delayed-Onset Reactions in Ragweed Hay Fever. Am. Acad. Allergy and Immunol., 1976. 29. Chiu, J., Mason, R., and Yoo, T.J.: Tumor Specific Antigen from Morris Hepatoma 7777. 1978 FASEB AAI. 30. Graeve, J.L., Whiteaker, R.S., Rim, K., and Yoo, T.J.: Suppressor Lymphocytes in a Rat Mammary Adenocarcinoma Model. 1978 Iowa Academy of Sciences Abstract. 31. Yoo, T.J., Kuo, C., Patil, S., Kim, U., Ackerman, L., and Cancilla, P.: Loss of Alphafetoprotein in Tissue Culture. A Medical Symposium on the Production by Malignant Tissue of Tumor Antigens, Hormones, and Enzymes, 1978. 39 32. Yoo, T.J., Kuan, K., Vestling, C.S., and Kuo, C.Y.: The Effect of Glucocorticoids on the Production of Alphafetoprotein, Lactic Dehydrogenase and Melate Dehydrogenase in Morris Hepatoma 7777 In Vitro. A Medical Symposium on the Production by Malignant Tissue of Tumor Antigens, Hormone, and Enzymes, 1978. 33. Yoo, T.J.: Con A Induced Suppressor Cells in Ragweed Allergy. Am. Acad. Allergy, 1979. 34. Chiu, H.C., Reinders, E., and Yoo, T.J.: Partial Purification of Active Allergenic Components from Alternaria. Am. Acad. Allergy, 1979. 35. Yoo, T.J., Kuo, C., Patil, S., Kim, U., Ackerman, L., Cancilla, P., and Chiu, H.C.: Control of Oncofetal Antigen Production as an Epiphenomenon of Tumorigenesis. 1979, FASEB AAI. 36. Whiteaker, R.S. and Yoo, T.J.: Mitogenesis-Enhancing Adherent Cells in a Rat Mammary Adenocarcinoma. 1979 FASEB AAI. 37. Chiu, H.C., Yoo, T.J., Spector, A.A., Kim, J., and Denning, G.M.: Effects of Fatty Acid Modification on Immunocytolysis of Hepatoma Cells. 1979 FASEB AAI. 38. Yoo, T.J.: Mechanism of Immunotherapy: Role of suppressor cells. Symposium on “Recent Advances in Allergy and Clinical Immunology” K,M.A. & K.M.A.A., Seoul, Korea, July, 1979. 39. Patil, S.R., Yang, V., Chiu, H.C., and Yoo, T.J.: Chromosome Characterization In a-FP and NON a-FP Producing Rat Hepatoma Cells. Depts. of Pediatrics and Medicine, University of Iowa Hospital and Clinics, and V.A. Med. Ctr., Iowa City, Iowa. Cancer Research, 1979. 40. Yoo, T.J., Whiteaker, R.S., Kim, H., and Lee, N.: Modification of the Fatty Acid Composition of Cultures Hepatoma Cells and Their Susceptibility to Lysis by Natural Killer Cells. Dept. of Medicine, University of Iowa, Iowa City, Iowa. Clinical Research (Central Society), 1979. 41. Yoo, T.J., and Lee, N.: Modification of Fatty Acid Composition of Cultured Hepatoma Cells and Their Susceptibility to Immune Cytolysis. Fed. Proc. 39:2. 1980. 42. Chiu, H.C., Hoang, T.A., and Yoo, T.J.: A New Allergen From Alternaria Tenius. Fed. Proc. 39:3, 1980. 43. Whiteaker, R.S., Lee, N., and Yoo, T.J.: Cytotoxic Studies of Metastasizing Rat Mammary adenocarcinoma. Fed. Proc. 39:3, 1980. 44. Whiteaker, R.S., Abbas, M., Lee, N., and Yoo, T.J.: Cytotoxic Studies of Metastasizing Rat Mammary Adenocarcinoma. 4th International Congress of Immunology of the International Union of Immunological Societies, 10.7.33, 1980. 45. Yoo, T.J., Chiu, H.C., and Spector, A.A., et al: Effect of Fatty Acid Modifications of Cultured Hepatoma Cells on Susceptibility to Complement Mediated Cytolysis. 4th International Congress of Immunology of the International Union of Immunological Societies. 15.2.12, 1980. 46. Chiu, C.H., Cazin, J., Kuo, C.Y., Roger, G., Chung, T.W., Lieberman, P., Crawford, L., and Yoo, T.J.: Allergic Properties of Different Sources of Alternaria Antigens. American Academy of Allergy. 47. Lieberman, P., Lewis, J., Treadwell, G., Erffmeyer, J., Taylor, W., Yoo, T., Gatewood, J., and Siegle, R.: Exercise Induced Urticaria, Angioedema, and Anaphylaxis. American Academy of Allergy. March, 1981. 40 48. Kuo, C.Y., Song, A.S., and Yoo, T.J.: Anti-tumor Immunity to L5178Y Lymphoma in Syngeneic Mice. AACR, 1981. 49. Kuo, C.Y., Song, A.S., and Yoo, T.J.: Possible Role of Shredded Fc Receptor in Tumor Cell Escape. FASEB 1981. 50. Floyd, R., Kuo, C.Y., Garcia, M., Song, A. Postlethwaite, A., and Yoo, T.J.: Effect of Protease Inhibitors on NK and ADCC Activities. FASEB. 1981. 51. Floyd, R.A., Chiang, T.M., Kuo, C.Y., Stone, G., Postlethwaite, A.R., Kang, A.H., Tomoda, K., and Yoo, T.J.: Effect of Sunflower and Coconut Oil Diets on Immune Responses in DBA/2 Mice and W/FU Rats. Fed. Proc. 41:341, 1982. 52. Yoo, T.J., Tomoda, K., Stuart, J., Kang, A.H., Cremer, M.A., and Townes, A.: Collagen-Induced Autoimmune Neurosensory Hearing Loss, Vestibular Dysfunction, and Otosclerosis in Rodents. Fed. Proc. 41:441, 1982. 53. Stuart, J.M, Yoo, T.J., Kang, A.H., Townes, A.S., Tomoda, K., and Dixit, S.N.: Collagen Autoimmunity as a Cause of Otosclerosis. Fed. Proc. 41:441, 1982. 54. Kuo, C.Y., Budd, T.W., Budd, C., Hsu, P.W., Yoo, T.J. and Patil, S.R.: Loss of Tumorigenicity in a Long-Term Myeloid Leukemic Cell Culture: Possible NK-Cell Mediated Surveillance. Fed. Proc. 41:406, 1982. 55. Budd, T.W., Kuo, C.Y., Yoo, T.J., and Cazin, J.: Isolation of a Unique Basic Peptide Allergen from Alternaria Extracts. Fed. Proc. 41:827, 1982. 56. Budd, T.W., Kuo, C.Y., Yoo, T.J., and Cazin, J.: The Isolation of a Unique Basic Peptide Allergen from Alternaria Extracts. American Academy of Allergy. 1982. 57. Yoo, T.J., Tomoda, K., Stuart, J., Kang, A.H., Cremer, M.A., and Townes, A.: Collagen-Induced Autoimmune Neurosensory Hearing Loss, Vestibular Dysfunction, and Otosclerosis in Rodents. Abstract 61, Mid-Winter ARO. 1982. 58. Yoo, T.J., Stuart, J.M., Kang, A.H., Townes, A.S., and Tomoda, K.: Collagen Autoimmunity as a Cause of Otosclerosis and Meniere’s Disease. Abst. 121, MidWinter ARO. 1982. 59. Yoo, T.J., Tomoda, K., and Cremer, M.A.: Type II Collagen Induced Autoimmune Spongiosis-like Lesions and a New Hypothesis for the Pathogenesis of Otospongiosis. ARO, Abstract #48, Fall, 1982. 60. Yoo, T.J., Yazawa, Y., Cremer, M.A., Tomoda, K., and Floyd, R.: ANtibody Activity Against Type II Collagen in the Inner Ear Fluid from TYpe II Collagen Induced Autoimmune Inner Ear Disease in Guinea Pigs and Rats. ARO, Abstract #52, Fall, 1982. 61. Tomoda, K. and Yoo, T.J.: Type II Collagen Induced Autoimmune Salpingitis. ARO, Abstract #49, Fall, 1982. 62. Yoo, T.J., Tomoda, K., and Hernandez, A.: Type II Collagen Induced Autoimmune Immune Ear Disease in the Guinea Pig. ARO, Abstract #50, Fall, 1982. 63. Yoo, T.J., Oh, J.H., Floyd, R., Shea, J.J., and Tomoda, K.: A Suggestive Linkage of HLA-DR4 Loci in Otosclerosis Patients. ARO, Abstract #51, Fall, 1982. 64. Yoo, T.J. and Tomoda, K.: Type II Collagen Distribution in the Inner Ear. ARO, Abstract #49:36, Midwinter, 1983. 65. Grant, W., Orman, S., Kuo, C.Y., Budd, T., Taylor, W.W., Lieberman, P., Yoo, T.J., Study of Basic Protein Allergens in Alternaria Allergy. J. Allergy Clin. Immunol. 71 (No. 1, Pt. 2): 96, Abstract #30, 1983. 41 66. Yoo, T.J., Tomoda, K., Yazawa, Y., and Kang, A.: Type II Collagen Autoimmunity and Meniere’s Disease. Fed. Proc. 42:1210, 1983. 67. Yoo, T.J. and Tomoda, K.: Type II Collagen Distribution in the External and Middle Ears. ARO, Abstract #154:111. Midwinter, 1983. 68. Kuo, C.Y., Orman, S., Grant, W. Taylor, W.W., and Yoo, T.J.: Studies of Reaginic Immune Responses to Alternaria Allergens in Mice. J. Allergy Clin. Immunol 71(No. 1, Pt. 2): 160, Abstract, #286, 1983. 69. Yazawa, Y., Floyd, R., Tomoda, K., and Yoo, T.J.: Antibody Activity Against Type II Collagen in the Inner Ear Fluid from Autoimmune Inner Ear Disease in Guinea Pigs. FASEB, 1983. 70. Tomoda, K., Ishibe, T., and Yoo, T.J.: Type II Collagen Induced Autoimmune Eustachian Tube Disease. FASEB, 1983. 71. Kuo, C.Y., Yoo, T.J., Seyer, J., Taylor, W.W., and Chung, T.W.: Alternaria Allergens: Comparative Studies of the Basic and Acidic Components. 5th International Congress of Immunology, August 1983. 72. Tomoda, K., and Yoo, T.J.: Type II Collagen Induced Autoimmune Eustachian Tube Disease. 5th International Congress of Immunology, August 1983. 73. Yoo, T.J., Yazawa, Y, Tomoda, K., and Yoo, T.J.: Type II Collagen Autoimmunity and Meniere’s Disease. 5th International Congress of Immunology, August 1983. 74. Yoo, T.J. and Tomoda, K.: Type II Collagen Induced Autoimmune Spongiosis Like Lesions and a New Hypothesis for the Pathogenesis of Otospongiosis. 5th International Congress of Immunology, August 1983. 75. Yazawa, Y., Floyd, R., Tomoda, K., and Yoo, T.J.: Antibody Activity Against Type II Collagen in the Inner Ear Fluid from Autoimmune Inner Ear Disease in Guinea Pigs. 5th International Congress of Immunology, August 1983. 76. Yoo, T.J., Yazawa, Y., Tomoda, K., and Yoo, T.J.: Type II Collagen Autoimmunity and Meniere’s Disease. 5th Int’l. Congress of Immuno., 1983. 77. Yoo, T.J., Tomoda, K., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Cell Transfer of Collagen Induced Autoimmune Ear Disease. Fall Assoc. Res. Oto., 1983. 78. Ishibe, T., Yoo, T.J., Yazawa, Y., Tomoda, K., Shea, J.J., Cremer, M.A., and Kang, A.H.: Type II Collagen Distribution in the Fetus Ear. Fall Ass. Res. Oto., 1983. 79. Yoo, T.J., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Serum Transfer of Collagen Induced Autoimmune Ear Disease in Rats. ARO Midwinter, 1984. 80. Yazawa, Y., Sudo, N., Floyd, R., and Yoo, T.J.: Surface Preparation Studies of Collagen Induced Ear Disease in Animals. ARO Midwinter, 1984. 81. Yoo, T.J., Yazawa, Y., Ishibe, T., Tomoda, K., and Floyd, R.A.: Type II Collagen Induced Tympanosclerosis in Guinea Pigs. ARO Midwinter, 1984. 82. Irwin, R., Lieberman, P., Kaplan, R., Kaliner, M., Treadwell, G., and Yoo, T.J.: Mediator Release in Local Heat Urticaria (LHU): Protection with Combined H1 and H2 Antagonists. Am. Academy of Allergy and Immunol., 1983. 83. Yoo, T.J., Yazawa, Y., Floyd, R.A., and Ishibe, R.: Serum Transfer of Collagen Induced Autoimmune Ear Disease in Rats. ARO Midwinter, Abstract #29, pg. 20, 1984. 84. Yazawa, Y., Sudo, N., Floyd, R., and Yoo, T.J.: Surface Preparation Studies of Collagen Induced Ear Disease in Animals. ARO Midwinter, Abstract #28, pg. 20, 1984. 42 85. Yoo, T.J., Yazawa, Y., Ishibe, T., Tomoda, K., and Floyd, R.A.: Type II Collagen Induced Tympanosclerosis in Guinea Pigs. ARO Midwinter, Abstract #147, pg. 105, 1984. 86. Yoo, T.J., Yazawa, Y., Ishibe, T., Floyd, R.A., Sudo, N., and Kuo, C.Y.: Type II Collagen Induced Inner Ear Diseases in Chinchilla. ARO Midwinter, Abstract, #30, pg. 21, 1984. 87. Yoo, T.J., Sudo, N., Ishibe, T., Yazawa, Y., and Floyd, R.A.: Effect of Steroid Hormone and Sulindac on Collagen Induced Autoimmune Ear Disease. ARO Midwinter, Abstract #146, pg. 105, 1984. 88. Yoo, T.J. and Yazawa, Y.: A Hypothesis of Etiopathogenesis and Mechanisms of Attack in Meniere’s Disease. ARO Midwinter, Abstract #27, pg. 19, 1984. 89. Kang, A.H., Yoo, T.J., Yazawa, Y., Orchik, D., Floyd, R.A., Olson, G., Sudo, N., Ishibe, T., Shea, T.J., and Takeda, T.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkey. ASBC/AAI Meeting, St. Louis, MO, June, 1984. 90. Ishibe, T., Yoo, T.J., Yazawa, Y., Tomoda, K., Shea, J.J., Cremer, M.A., and Kang, A.H.: Type II Collagen Distribution in the Fetus Ear. ASBC/AAI Meeting, St. Louis, MO, June, 1984. 91. Yoo, T.J.: A Hypothesis of Etiopathogenesis of Meniere’s Disease as an Autoimmune Disease. ASBC/AAI Meeting, St. Louis, MO, June,1984. 92. Yoo, T.J., Yazawa, Y., Ishibe, T., Tomoda, K., and Floyd, R.A.: Type II CollagenInduced Tympanosclerosis in Guinea Pigs. ASBC/AAI Meeting, St. Louis, MO, June, 1984. 93. Yoo, T.J., Yazawa, Y., Ishibe, T., Floyd, R., Sudo, N., and Kuo, C.Y.: Type II Collagen-Induced Inner Ear Diseases in Chinchilla. ASBC/AAI Meeting, St. Louis, MO, June, 1984. 94. Cohen, R., Grant, B., Lieberman, P., Potter, W., Golden, S., Crawford, L., Herrod, H., and Yoo, T.J.: The Use of Methacholine Inhalation, Methacholine Skin Testing, Distilled Water Inhalation Challenge and Eosinophil Counts in the Evaluation of Patients Presenting with Cough and/or Nonwheezing Dyspnea. American Academy of Allergy & Clinical Immunology, 1984. 95. Kuo, C.Y., Yoo, T.J., Chung, B.U., and Mansfield, L.E.: In Vitro Test for Evaluation of Chemonucleosis Immediate Hypersensitivity. ASBC/AAI Meeting, June, 1984. 96. HSU, P.W., Kuo, C.Y., Budd, C.A., Budd, T.W., and Yoo, T.J.: Syngeneic Tumor Rejection in C57B1/6 Mice by Alloactivated Helper T-Cells. ASBC/AAI Meeting, June, 1984. 97. Tomoda, K., Kumazawa, T., and Yoo, T.J.: Immunological Basis of Meniere’s Disease. British Otorhinolaryngological Research Society (O.R.S.), April, 1984. 98. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. Fed. Proc. 44(4): 955, Abstract #3183, April, 1985. 99. Sudo, N., Floyd, R., Ishibe, T., and Yoo, T.J.: Cell Transfer of Collagen-Induced Autoimmune Ear Diseases in Guinea Pigs. Fed. Proc. 44(4): 955, Abstract#3184, April, 1985. 100. Floyd, R., Cremer, M., Sudo, N., Takeda, T., Ishibe, T., and Yoo, T.J.: Induction of Tolerance to Type II Collagen Autoimmune Ear Disease in Rats. Fed. Proc. 44(4):955, Abstract #3185, April, 1985. 43 101. Yazawa, K., Sudo, N., Ishibe, T., Takeda, T., Floyd, R., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. Fed. Proc. 44(4):958, Abstract #3198, April, 1985. 102. Hue, S.H., Kim, H.Y., Floyd, R.A., and Yoo, T.J.: Modified Alternaria Allergen Immunotherapy in Mice. Fed. Proc., pg. 303, Abstract #8569, April, 1985. 103. Yoo, T.J., Stuart, J.M., Takeda, T., Sudo, N., Floyd, R., Ishibe, T., Olson, G., Orchik, D., Shea, J.J., and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkey. J. Allergy Clin. Immunol., Vol., 75 (No. 1, Pt. 2, Suppl.):202, Abstract #389, March, 1985. 104. Takeda, T., Orchik, D., Floyd, R.A., Ishibe, T., Sudo, N., Yazawa, Y., Olson, G., Shea, J.J., and Yoo, T.J.: Electrocochleographic Study of Non-Human Primates with Collagen-Induced Ear Disease. ARO, Abstract #74:61, Midwinter, 1985. 105. Takeda, T., Stuart, J.M., Floyd, R.A., and Yoo, T.J.: Auditory Brain Stem Response (ABR) in Rodents with Type II Collagen-Induced Autoimmune Ear Diseases. ARO, Abstract #109:88, Midwinter, 1985. 106. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. ARO, Abstract #110:89, Midwinter, 1985. 107. Yoo, T.J., Sudo, N., Floyd, R., Ishibe, T., and Tomoda, K.: Type II Collagen-Induced Autoimmune Salpingitis in the Rat. ARO, Abstract #111:90, Midwinter, 1985. 108. Sudo, N., Yazawa, Y., Ishibe, T., Takeda, T., Floyd, R.A., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. ARO Abstract #112:90, Midwinter, 1985. 109. Ishibe, T. and Yoo, T.J.: Type II Collagen Distribution in the Monkey Ear. ARO, Abstract #113:91, Midwinter, 1985. 110. Ishibe, T., Yoo, T.J., Shea, K., and Tomoda, K: Immunohistochemical Studies in Meniere’s Disease, Otosclerosis and Tympanosclerosis. ARO, Abstract, #114:92, Midwinter, 1985. 111. Ishibe, T., Choe, I.S., and Yoo, T.J.: Type II Collagen in the Human and Monkey Ear. World Cong. of Oto. Rhino. Laryn. 1(1): 222, Abstract #691, May 1985. 112. Ishibe, T., Tomoda, K., and Yoo, T.J.: Type II Collagen in the Human and Monkey Ear. World Cong. of Oto. Laryn. 1(1): 222, Abstract #691, May, 1985. 113. Sudo, N., Tomoda, K., Floyd, R., Ishibe, T., and Yoo, T.J.: Type II Collagen-Induced Autoimmune Salpingitis in the Rat. World Cong. of Oto. Rhino. Laryn 1(1): 224, Abstract #697, May, 1985. 114. Takeda, T., Orchik, D., Floyd, R., Ishibe, T., Sudo, N., Yazawa, Y., Olson, G., Shea, J.J., and Yoo, T.J.: Electrocochleographic Study of Non-Human Primates with Collagen-Induced Ear Disease. World Cong. Oto. Rhino. Laryn. 1(1):296, Abstract #927, May, 1985. 115. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R., and Ishibe, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. World Cong. of Oto. Rhino. Laryn. 1(1):297, Abstract #930, May 1985. 116. Yazawa, Y., Yoo, T.J., Ishibe, T., and Tomoda, K.: Type II Collagen Induced Tympanosclerosis Model in Guinea Pigs. World Cong. Otol. Rhino. Laryn. 1(1):297, Abstract #931, May 1985. 44 117. Yoo, T.J., Cremer, M., Sudo, N., Takeda, T., Floyd, R., and Ishibe, T.: Induction of Tolerance to Type II Collagen Autoimmune Disease in Rats. World Cong. Otol. Rhino. Laryn. 1(1):340, Abstract #1094, May 1985. 118. Ishibe, T., Choe, I.S., and Yoo, T.J.: Type II Collagen Development in the Embryonic Chick Ear. World Cong. Oto. Rhino. Laryn. 1(1):340, Abstract #1095, May 1985. 119. Ishibe, T., Tomoda, K., Yoo, T.J., Shea, J.J., and Causse, J.B.: Immunochemical Studies in Meniere’s Disease Otosclerosis, and Tympanosclerosis. World Cong. Oto. Rhino. Laryn. 1(1):340, Abstract #1096, May 1985. 120. Sudo, N., Yazawa, Y., Ishibe, T., Takeda, T., Floyd, R., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. World Cong. Oto. Rhino. Laryn. 1(1):341, Abstract #1098, May, 1985. 121. Takeda, T., Stuart, J.M., Floyd, R.A., and Yoo, T.J.: Auditory Brain Stem Response (ABR) in Rodents with Type II Collagen-Induced Autoimmune Ear Diseases. World Cong. Oto. Rhino. Laryn. 1(1):341, Abstract, #1099, May 1985. 122. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., Ishibe, T., and Takeda, T.: A Guinea Pig Model of Autoimmune Endolymphatic Hydrops. NYAS, 1985. 123. Yoo, T.J., Stuart, J.M., Takeda, T., Sudo, N., Floyd, R., Ishibe, T., Olson, G., Orchik, D., Shea, J.J., and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkey. NYAS, 1985. 124. Yoo, T.J., Takeda, T., Sudo, N., Floyd, R., Olson, G., and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkey. Int’l. AACI, 1985. 125. Floyd, R.A., Hue, S.H., Kim, H.Y., and Yoo, T.J.: Modified Alternaria Allergen Immunotherapy in Mice. Int’l. AACI, 1985. 126. Sudo, N., Yoo, T.J., and Floyd, R.A.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. Int’l. AACI, 1985. 127. Yoo, T.J.: Type II Collagen Mediated Autoimmune Middle Ear Disease: Eustachian Tube Disease, Otitis Media with Effusion and Tympanosclerosis. Int’l. Symposium, pg. 56, Abstract, #6, Japan, 1985. 128. Yoo, T.J., Sudo, N., Floyd, R., Ishibe, T., and Tomoda, K.: Type II Collagen-Induced Autoimmune Salpingitis in the Rat. Int’l Symposium, pg. 94, Abstract #7, Japan, 1985. 129. Yazawa, Y., Yoo, T.J., Ishibe, T., and Tomoda, K.: Type II Collagen-Induced Tympanosclerosis Model in Guinea Pigs. Int’l. Symposium, pg. 95, Abstract #8, Japan, 1985. 130. Yoo, T.J., Floyd, R.A., Sudo, N., Takeda, T., Ishibe, T., and Choe, I.S.: Factors Influencing Collagen-Induced Autoimmune Ear Disease (CIAED). Int’l. Conf. Current Aspects of Basic Clin. Ear. Res., pg. 16, Japan, 1985. 131. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. American Association of Immunologists Meeting, Anaheim, CA., April 1985. 132. Sudo, N., FLoyd, R., Ishibe, T., and Yoo, T.J.: Cell Transfer of Collagen-Induced Autoimmune Ear Diseases in Guinea Pigs. American Association of Immunologists Meeting, Anaheim, CA, April, 1985. 133. Floyd, R., Cremer, M., Sudo, N., Takeda, T., Ishibe, T., and Yoo, T.J.: Induction of Tolerance to Type II Collagen Autoimmune Ear Disease in Rats. American Association of Immunologists Meeting, Anaheim, CA, April, 1985. 45 134. Yazawa, K., Sudo, N., Ishibe, T., Takeda, T., Floyd, R., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. American Association of Immunologists Meeting, Anaheim, CA, April, 1985. 135. Hue, S.H., Kim, H.Y., Floyd, R.A., and Yoo, T.J.: Modified Alternaria Allergen Immunotherapy in Mice. American Association of Immunologists Meeting, Anaheim, CA, April, 1985. 136. Yoo, T.J., Takeda, T., Sudo, N., Stuart, J.M., FLoyd, R.A., Ha, S.C., Wolf, B., DaCunha, C., Kim, S.W., Choe, I.S., Guia, M. Collagen-induced autoimmune ear disease (CIAED) in mice: Localization of inner ear disease inducing determinant to a fragment of type II Collagen molecules. ARO Annual Meeting, Clearwater, FL, February, 1986. 137. Wolf, B.L., Kim, S.Y., Floyd, R.A, DaCunha, C., Ha, S.C., Rao, G., Ky, N., Hoidal, J., Yoo, T.J. Experimental laminin induced pneumonitis: Effect of smoking. American Academy of Allergy and Immunology, New Orleans, LA, March, 1986. 138. Floyd, R.A., Hue, H.S., Kim, Y.H., Dean, P., Kim, S.Y., DaCunha, C., Dixit, S.N., Yoo, T.J. Type IV collagen induced glomerulonephritis in guinea pigs. American Academy of Allergy and Immunology, New Orleans, LA, March, 1986. 139. Yoo, T.J., Takeda, T., Sudo, N., Stuart, J.M., Floyd, R.A., Ha, S.C., Kim, S.Y., Kitano, M.D., DaCunha, C., Choe, I.S., Wolf, B., Ilfeld, D. Localization of an inner ear disease inducting determinant of the Type II collagen molecule. American Academy of Allergy and Immunology. New Orleans, LA, March 1986. 140. Kim, S., Cremer, M., Ha, S., Floyd, R., Stuart, M.D., Kang, A.H., Yoo, T.J. Collageninduced arthritis in rhesus monkeys: Arthrogenic determinants of CNBr Fragments, FASEB, April 1985. 141. Wolf, B.L., Kim, S.Y., Floyd, R.A., DaCunha, C.Ha, S.C., Rao, G., Ky, N., Hoidal, J., Yoo, T.J. Experimental Laminin-induced pneumonitis: Effect of smoking. FASEB, April, 1986. 142. Floyd, R.A., Hue, H.S., Kim, Y.H., Dean, P., Kim, Y.H., Dean, P., Kim, S.Y., DaCunha, C., Dixit, S.N., Yoo, T.J. Type IV Collagen-Induced Glomerulonephritis in Guinea Pigs. FASEB, April 1986. 143. Cole, S. and Yoo, T.J. Enhancement of Type IV Collagen or Laminin Induced Lung Injury By Oxygen Exposure. Am. Coll. Allergist. Las Vegas, NE, January, 1987. 144. Kitano, H., Cremer, M., Yoo, T.J. Production of hearing loss by monoclonal antibody against type II collagen in mice. Am. Acad. Allergy and Clinic. Imm., January, 1987. 145. Yoo, T.J., Cremer, M., Sudo, N., Takeda, T., Floyd, R., Ha, S. Inner ear disease including determinants of CNBr fragments in monkey with collagen induced autoimmune ear disease (CIAED). Am. Acad. Allergy and Clinic. Imm., January, 1987. 146. Wolf, B.L., Pifer, L.W., J., Ilfeld, D., Herrod, H., Floyd, R.A., Woods, D., Gross, S., Yoo, T.J. Treatment of AIDS patients with transfer factor. Am. Acad Allergy and Clinic. Imm., January, 1987. 147. Floyd, R.A., and Yoo, T.J. Immune response of patients with autoimmune sensorineural hearing loss. FASEB, Washington, D.C., February, 1987. 148. Ha, S.C. and Yoo, T.J. Induction of type II collagen-specific T cell hybridomas. FASEB, April 1987. 149. Shikata, N., Floyd, R., Taylor, W.W. and Yoo, T.J. Laminin induced glomerular basement membrane disease in hamster. FASEB, April, 1987. 46 150. Kitano, H., Cremer, M. and Yoo, T.J. The effect of local immunization in endolymphatic sac (ELS) on the production of type II (CII) collagen induced ear disease (CIAED). FASEB, April, 1987. 151. Yoo, T.J., Kitano, H., Floyd, R., Ha, S., Harada, T., Shikata, N., Cremer, M. Collageninduced autoimmune ear diseases (CIAED): Animals models update. 3rd Int. Symposium on Tinnitus, Germany, June, 1987. 152. Ha, S.C., Yoo, T.J., Induction of Type II Collagen Specific T Cell Hybridomas, ARO, Clearwater, FL., February, 1988. 153. Gupta, R.C., Land, M.A., Krishnan, M.R., Endres, R.O., Smalley, D.L., and Yoo, T.J., Effect of Sera from Patients with Aids on Endothelial Cell Proliferation and Role of Interferon- (IFN- ), lst Pan American Conference on AIDS,Guadeltrau, Mexico, February, 1988. 154. Yoo, T.J., Ha, S., Cole, S., Floyd, R., Huang, M.C., Seyer, J., Molecular Characterization of Epitope Responsible for Type II Collagen Induced Disease, Amer. Acad. All. & Imm., Anaheim, CA. March, 1988. 155. Floyd, R.A., Seyer, J., Yoo, T.J., Immune Response of Patients with Autoimmune Sensorineural Hearing Loss, Amer. Acad. All. & Imm., Anaheim, CA. March, 1988. 156. Kitano, H., Cremer, M., Yoo, T.J., The Effect of Local Immunization in Endolymphatic Sac (ELS) on the Production of Type II (CII) Collagen Induced Ear Disese (CIAED), Amer. Acad. All & Imm., Anaheim, CA., 3/1988. 157. Kitano, H., Cremer, M., Yoo, T.J., Production of Type II Collagen (CII) Induced Endolymphatic Hydrops (CIEH): The Effect of Local Immunization in Endolymphatic Sac (ELS)., 2nd Int. Sym. Men. Dis., June, 1988. 158. Yoo, T.J., Ha, S., Floyd, R., Huang, M.C., and Seyer, J., Molecular Characterization of Epitope Responsible for Type II Collagen Induced Ear Disease and Autoimmune Sensorineural Hearing Loss and Endolymphatic Hydrops, Immunointervention, Paris, June, 1988. 159. Nam, S.H., Ishibe, T., Shikata, N., Shin, H.S., Nakatani, H., Kitano, H., Cremer, M., Brackmann, D.E., and Yoo, T.J., Type IX Collagen in Ear Tissues,ARO, February, 1989. 160. Nam, S.H., Lavery, J.P., Ishibe, T., Shikata, N., Shin, H.S., Nakatani, H., Kitano, H., Cremer, M., Brackmann, D.E., and Yoo, T.J., Type IX Collagen and Immune Response in Ear Tissues, AAAI, March, 1989. 161. Lee, J.S., Ong, R., Chiang, T.M., Wyatt, R.J., Jung, T.K., and Yoo, T.J., Binding of Platelat Activating Factor (PAF) by Isolated Membranes from U937 Cells, AAAI, March, 1989. 162. Yoo, T.J., Nam, S.H., Ye, X.I., Nakatani, H., Cho, J.S., Shin, H.S., Huang, M.C., Seyer, J., The Epitope Structure for Type II Collagen Induced Ear Lesion in DAB-1J Mice, AAAI, March, 1989. 163. Yoo, T.J., Nam, S.H., Nakatani, H., Ye, X.I, Huang, M.C., and Seyer, J., Molecular Characterization of Epitope Responsible for Type II Collagen Induced Ear Disease in Rhesus Monkey and Mice, FASEB, March, 1989. 164. Nam, S.H., Nakatani, H., Ye, X.I., Shikata, N., Shin, H.S., Cho, J.S., Cremer, M., Lavery, J.P., and Yoo, T.J., Type IX Collagen and the Autoimmune Response in Ear Tissues, FASEB, March, 1989. 47 165. Ong, R., Lee, J.S., Chiang, T.M., Wyatt, R.J., Jung, T.K., and Yoo, T.J., Binding of Platelat Activating Factor (PAF) by Isolated Membranes From U937 Cells, FASEB, March, 1989. 166. Cho, J.S., Yoo, T.J., Effect of local Immunization of Type II Collagen Induced Ear Disease, IEB, Paris, France, September, 1989. 167. Yoo, T.J., Nakatani, H., Cho, J.S., Nam, S.H., Shin, H.S., Ye, X.I., Lavery, J.P., Experimental Animal Model for Immunologically Induced Inner Ear Lesions., XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 168. Cho, J.S., Harada, T., Kitano, H., Cho, J.K., Yoo, T.J., Effect of Local Immunization of Type II Collagen Induced Ear Disease. XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 169. Harada, T., Kitano, H., Matsumaga, T., Yoo, T.J., Interleukin-1 (IL-1) Induced Inner Ear Lesion: IL-1 Increased Macrophages in the Endolymphatic Sac and Hearing Loss in Mice, XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 170. Nakatani, H., Nam, S.H., Ye, X.J., Yoo, T.J., Auditory Brainstem Response of Guinea igs Immunized with Various Matrix Proteins: Type II, Type IV and Type IX Collagens, Laminine and Labyrinthine Membranes, XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 171. 169. Kitano, H., Yoo, T.J., Production of Type II Collagen (CII) Induced Endolymphatic Hydrops (CIEH): The Effect of Local Immunization in Endolymphatic Sac (ELS), XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 172. Nam, S.H., Cho, J.S., Shikata, N., Shin, H.S., Nakatani, H., Kitano, H., Brackman, D.E., and Yoo, T.J., Type IX Collagen and Immune Response in Ear Tissues, XIV World Congress of Otorhinolaryngology, Head & Neck Surgery, Madrid, Spain, September, 1989. 173. Cho, J.S., Nakatani, H., and Yoo, T.J., Contralateral Effects of Inner Ear to Local Challenge in Guinea Pigs Immunized with Type II Collagen, CIS, November, 1989. 174. Ong, R.C., Yoo, T.J., and Chiang, T.M., Platelet Activating Factor -U937 Interaction: Possible Involvement of Protein Kinase, Am. Col All. & Immun., November, 1989. 175. Kim, H.W., Cho, J.S., Nakatani, H., and Yoo, T.J., The Effect of Local Immunization in Type II Collagen (CII) Induced Inner Ear Disease, Am. Col, All., & Immun., November, 1989. 176. Ong, R.C., Chiang, T.M., and Yoo, T.J., Platelet Activating Factor -U937 Interaction: Possible Involvement of Protein Kinase, ARO, February, 1990.Cho, J.S., Nakatani, H., and Yoo, T.J., Contralateral Effects of Inner Ear to Local Challenge in Guinea Pigs Immunized with Type II Collagen, ARO, February, 1990. 177. Slepecky, N.B., and Yoo, T.J., Ultrastructural Localization of Tectorial Membrane Components, ARO, February, 1990. 178. Ong, R.C, Taylor, W.W., Chiang, T.M., and Yoo, T.J., Platelet Activating Factor -U937 Interaction: Possible Mechanism(s) Involved in the Activation, AAAI, March, 1990. 179. Cho, J.S., Kim, R., Nakatani, H., and Yoo, T.J., Sympathetic Autoimmune Hearing Loss in Experimental Animals, AAAI, March, 1990. 48 180. Ye, X.J., Marion, T.N., Terato, K., Tillman, D.M., and Yoo, T.J., V-Region cDNA Sequences of Anti-Type II Collagen Antibodies Which Induce Relapsing Polychondritis in Mice, ASBMB/AAI, June, 1990. 181. Cho, J.S., Kim, R., Nakatani, H., Cho, H., and Yoo, T.J., Contralateral Effects of Inner Ear to Local Challenge in Guinea Pigs Immunized with Type II Collagen, ASBMB/AAI, June, 1990. 182. Ong, R.C., Kim, R., Chiang, T.M., and Yoo, T.J., Platelet Activating Factor U937 Interaction: Possible Involvement of Protein Kinase, ASBMB/AAI, June, 1990. 183. Yoo, T.J., Cho, H., Hearing Impairment in Mice with Cmd/Cmd (Cartilage Matrix Deficiency) Gene, Genetic Hearing Impairment, September, 1990. 184. Cho, H., Yoo, T.J., Ultrastructural Changes of Cochlea in Mice with Hereditary Chondrodysplasia (Cho/Cho), Genetic Hearing Impairment, September, 1990. 185. Cho, H., Buchanan, J., Strong, D., Yoo, T.J., The Molecular and Structural Basis of Hearing Impairment in Mice with CPK mutant gene, Genetic Hearing Impairment, September, 1990. 186. Kim, R., Lee, M., Spinella, G., Yoo, T.J., and Chiang, T.M., Increased Expression of mRNA for a 47 KDa Protein by Transforming Growth Factor-ß (TGF-ß) on U937 Cells., AAAI, October, 1990. 187. Lee, M.D., Ye, X.J., Marion, T.N., Terato, K., and Yoo, T.J., V-Region cDNA Sequences of Anti-type II Collagen Antibodies Which Induce Polychondritis in Mice, AAAI, October, 1990. 188. R. Ong, Bruggemen, L.A., Slepecky, N., Yamada, Y., Thompson, J., and Yoo, T.J., Production of Transgenic Mice for the Study of Type II Collagen Autoimmunity of Ear Disease, AAAI, October, 1990. 189. Yoo, T.J., Nakatani, H., Cho, J.S., Nam, S.H., Shin, H.S., Ye, X.I., Fujiyoshi, T., Joliat, T., Experimental Animal Model for Immunologically Induced Inner Ear Lesions, ARO, February, 1991. 190. Ong, R., Fujiyoshi, T., Bruggemen, L.A., Slepecky, N., Yamada, Y., Thompson, J., and Yoo, T.J., Production of Transgenic Mice for the Study of Type II Collagen Autoimmunity of Ear Disease, ARO, February, 1991. 191. Yoo, T.J., Cheng, K.C., Ye, X.J., Terato, K., Lee, M.K., Fujiyoshi, T., Seyer, J., Wang, K., Min, Y.S., Hood, L., T-cell receptor repertoire and immune recognition in autoimmune ear diseases, AAAI, October, 1991. 192. Jackson, B., Ye, X.J., Marion, T.N., Terato, K., Tillman, D.M., Krug, M.s., and Yoo, T.J., V-region cDNA sequences of anti-type II collagen antibodies, AAAI, October,1991. 193. Yoo, T.J., Cheng, K.C., Ye, X.J., Terato, K., Lee, M.K., Fujiyoshi, T., Seyer, J., Wang, K., and Hood, L., T-cell receptor repertoire and immune recognition in autoimmune ear diseases, ARO, February, 1992. 194. Joliat, T., Ye, X.J., Seyer, T., Bernstein, J., Cho, J.S., and Yoo, T.J., Antibody against a 30Kd cochlear protein and type II and IX collagen in the serum of patients with autoimmune ear disases, ARO, February, 1992. 195. Lee, M.K., Wang, K., Kuo, C.L., Cheng, K.C., Paper, B., Hood, L., and Yoo, T.J., Analysis of mouse T-cell receptor Va and Vg gene subfamilies, FASEB, 1992. 49 196. Yoo, T.J., Cheng, K.C., Ye, X.J., Terato, K., Lee, M.K., Fujiyoshi, T., Seyer, J., Wang, K., and Hood, L., T-cell receptor and peptide binding in autoimmune ear disease., FASEB, 1992. 197. Krug, M., Zandvliet, K., Readhead, C., Hood., L, Cheng, K.C., and Yoo, T.J., Generation of transgenic mice by human collagen a2(II) promotor and enhancer driven murine IFN-r, FASEB, 1992. 198. Cheng, K.C., Lee, M.K., Wang, K., Min, Y., Hood, L., and Yoo, T.J., Restrictive T-cell receptor usage in collagen induced ear autoimmune diseases, FASEB, April, 1992. 199. Yoo, T.J., Cheng, K.C., Ye, X.J., Terato, K., Lee, M.K., Fujiyoshi, T., Seyer, J., Wang, K., and Hood, L., T-cell receptor and peptide binding in autoimmune ear disease, Molecular Biology of Hearing and Deafness Conf., May, 1992. 200. Cheng, K.C., Lee, M.K., Wang, K., Min, Y., Hood, L., and Yoo, T.J., T-cell receptor repertoire in collagen induced autoimmune disease (CIAED)., Molecular Biology of Hearing and Deafness Conference, May, 1992. 201. Fujiyoshi, T., Readhead, C., and Yoo, T.J., Restoration of auditory evoke potential by myelin basic protein gene transfer in shiverer mice, Molecular Biology of Hearing and Deafness Conference, May, 1992. 202. Krug, M., Zandvliet, K., Lee, M.K., Hood, L., Cheng, K.C., and Yoo, T.J., Generation of transgenic mice by human collagen a2(II) promotor and enhancer driven murine IFNr, Molecular Biology of Hearing and Deafness Conf., May, 1992. 203. Joliat, T., Cho, J.S., Cha, C.Il., Ye, X.J., and Yoo, T.J., Antibodies against a 30Kd cochlear protein and type II and type IX collagen in the serum of patients with inner ear disease, Molecular Biology of Hearing and Deafness Conference, May, 1992.Bujia, J., 204. Sittinger, M., Yoo, T.J., Burmester, G., Cartilage Specific Autoimmunity in patients with otosclerosis , 1993. 205. Yoo, T.J., Fujiyoshi, T., Readhead, C., Hood, L., Restoration of auditory evoked potential by myelin basic protein (MBP) gene therapy in shiverer mice, ARO, February, 1993. 206. Krug, M., Cheng, K.C., Fujiyoshi, T., and Yoo, T.J., Generation of transgenic mice by human collagen a2(II) promotor and enhancer driven murine IFN-g, ARO, February, 1993. 207. Krug, M., Cheng, K.C., Fujiyoshi, T., and Yoo, T.J., Generation of transgenic mice by human collagen a2(II) promotor and enhancer, Amer. Acad. of Allergy & Immunology, March, 1993. 208. Cheng, K.C., Lee, M.K., Chiang, H.J., Wang, K., Yoo, T.J., Hood, L.E., Dominant inheritance of T-cell receptor a gene segment in experimental autoimmune encephalomyelitis, Amer. Acad. of Allergy & Immunology, March, 1993. 209. Lee, M.K., Wang, K., Cheng, K.C., Peper, B., Hood, L., and Yoo, T.J., Analysis of mouse T-cell receptor Va and Vb gene subfamilies, Amer. Acad. of Allergy & Immunology, March, 1993. 210. Yoo, T.J., Fujiyoshi, T., Hood, L., Readhead, C., Restoration of auditory evoked potential by myelin basic protein (MBP) gene therapy in shiverer mice, Keystone Suymposia, April, 1993. 211. Yoo, T.J., Fujiyoshi, T., Readhead, C., Hood, L., Restoration of auditory evoked potential by myelin basic protein (MBP) gene therapy in shiverer mice, XV World Cong. Otorhino, June, 1993. 50 212. Cheng, K.C., Fujiyoshi, T., Lee, M.K., Ye, X.J., Pyun, J and Yoo, T.J., T-cell receptor gene reperotire in autoimmune disease, Transformation in the Korean Peninsula, July, 1993. 213. Yoo, T.J., Joliat, T., Bernstein, J., Krug, M., and Seyer, J., Antibodies against a 30KD cochlear protein and type IX collagen in the serum of paients with Meniere’s disease, Meniere’s Disease Symposium, October, 1993. 214. Cheng, K.C., Oh, J.W., Buck, J.K., and Yoo, T.J., T-cell receptors with vb8 and vb6 gene segments recognized epitopes in collagen induced autoimmune disease, American College of Allergy, November,1993. 215. Krug, M., Cheng, K.C., Chang, Y, and Yoo, T.J., Generation of transgenic mice by human collagen a2(II) promotor and enhancer driven murine IFN-g, American College of Allergy, November, 1993. 216. Cheng, K.C., Zhang, Y, Watanabe, T., Krug, M., Buck, J., Park, S.J., and Yoo, T.J., Immune mechanism of housedust mite induced allergic disorder in mice, American College of Allergy, November, 1993. 217. Watanabe, T., Krug, M.S., Cheng, K.C., and Yoo, T.J., Myelin basic protein promoter driven g-interferon (gIFN) transgenic mice for the study of autoimmune disease, American College of Allergy and Immunology, November, 1993. 218. Cheng, K.C., Yoo, T.J., “Restrictive usage of T-cell receptor (TCR) gene in myelin basis protein (MBP induced experimental autoimmune encephalomyelitis in SJL/J mice, AAAI, 1994. 219. Ye, X.J., Marion, T., Terato, K., Aleion, J., Krug, M., Yoo, T.J., “Variable regional gene family usage for type II collagen autoantibodies in arthritis-susceptible DBA/1 mice”, AAAI, 1994. 220. Buck, J., Cheng, K.C., Zhang, Y., Wanatable, T., Krug, M., Chang, H.K., Park, S.J., and Yoo, T.J., “Immune mechanism of housedust mite induced allergic disorder in mice”, AAAI, 1994. 221. Fujiyoshi, T., Cheng, K.c., and Yoo, T.J., “Molecular basis of type II collagen autoimmune polychondritis with ear lesion”, AAAI, 1994. 222. Krug, M.S., Fujiyoshi, T., Watanabe, T., and Yoo, T.J., “Myelin basic protein promoter driven g-interferon (gIFN) transgenic mice for the study of retrochochlear autoimmune disease”, AAAI, 1994. 223. Cheng, K.C., Oh, J.W., Buck, J.K, and Yoo, T.J., “T-cell receptors with Vb8 and Vb6 gene segments recognized epitopes in collagen induced autoimmune disease”, ACAI, 1994. 224. Krug, M., Cheng, K.C., Chang, Y, and Yoo, T.J., “Generation of transgenic mice by human collagen a2(II) promotor and enhancer driven murine IFN-g”, ACAI, 1994. 225. Krug, M.S., Fujiyoshi, T., Watanabe, T., and Yoo, T.J., “Myelin basic protein promoter driven g-interferon (gIFN) transgenic mice for the study of retrochochlear autoimmune disease”, ACAI, 1994. 226. Watanabe, T., Krug, M.S., Cheng, K.C., Fujiyoshi, T., and Yoo, T.J., “Myelin basic protein promoter driven g-interferon (gIFN) transgenic mice for the study of retrochochlear autoimmune disease”, ARO, 1994. 227. 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Yoo, A Case of Urticarial Vasculitis with Probable Autoantibody to High Affinity IGE Receptor or IGE,ACAAI San Diego, CA. 1997. 283. J. Fahhoum, T.J. Shen, H. Lee, K.C. Cheng, H. Matsuoka, T.J. Yoo, A single high dose injection of an immunodominant peptide of der Pi causes tolerization in house mite sensitized mice,ACAAI San Diego 1997. 284. Y.K. Kim, H.Y. Lee, J. Fahhoum, T.J. Yoo, Comparison of Aeroallergen Skin tests reactions between Korean and Memphis allergy patients,ACAAI San Diego, CA. 1997. 285. K.H. Park, D.S. Kim, K.Y. Lee, 11 Amino acid CDR3 Domain in Vk 111 Derived immunoglobulin light chains in Kawasaki Md., ACAAI San Diego, CA 1997. 286. N. Kim, S.S. Kwon, T.J. Yoo, Suppressive vaccination of allergen-induced immunoglobulin E production by the naked DNA vaccine,AAAAI 1990. 287. K.H. Park, H.Y. Kim, B.J. Jeong, Y.K. Kim, T.J. Yoo, Pediatric IgE antibody binding to the most common seafood proteins in Korea, AAAAI 1998. 288. Fahhoum, T.J. Shen, H.Y. Lee, K.C. Cheng, H. 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Yoo, Role of Autoantigens in patients with inner ear disease, AAAAI 1998. 295. H. Tanaka, H. Matsuoka, N.S. Kim, K.C. Cheng, Y, Yazawa, T.J. Yoo, Production of endolymphatic hydrops induced by directly infusing monoclonal antibody against Type II collagen CB11, AAI San Francisco, CA. 1998. 296. T.J. Yoo, H. Matsuoka, M. Suzuki, M.S. Krug, K.C. Mun, K.M. Lee, N.S. Kim, Y. Yazawa, K.C. Cheng, Raf-1 protein as a potential antigen in autoimmune inner ear disease, AAI San Francisco, CA 1998. 297. N.S. Kim, S.S. Kwon, T.J.Yoo, Suppressive vaccination of allergen-induce immunoglobulin E production by the naked DNA vaccine, AAI San Francisco, CA 1998. 298. H. Tanaka, H. Matsuoka, Y. Yazawa, N.S. Kim, K.C. Cheng, S.N. Tripuraneni, H. Kitano, T.J. Yoo, Production of endolymphatic hydrops induced by direct type II collagen into cochlea, ARO 1998. 299. K. C. Mun, H. Tanaka, N.S. Kim, T.J. Yoo, Role of autoantigens in patients with inner ear disease, ARO 1998. 300. T.J. Yoo, H. Matsuoka, M. 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Yoo, Immunoprotective effect of vaccination with DNA encoding T cell epitopes on the Der p induced IgE production.AAAAI 1999. JACI, Vol 103- No. 1, Jan. 1999- #418. 313. Kwon, S. S., N.S. Kim. K. M. Lee, K. C. Chen, T. J. Yoo, Th effect of the intradermal vaccination with DNA encoding the T cell receptor on the induction of experimental autoimmune encephalomyelitis in mice. AAAAI 1999, JACI, Vol 103- No. 1, Jan. 1999 # 76. 314. Alcordo, M.J., O. Sener, T. J. Yoo, Autoantibody to the proto-oncogene c-raf in the sera of patients with systemic lupus erythematosus, AAAAI 1999, JACI, Vol 103 -No. 1, Jan. 1999 # 77. 315. Kim, K.Y., K. H. Park, T. J. Yoo. Prognostic Factors for Interferon Gamma Treatment in Patients with Severe Atopic Dermatitis. JACI, Vol .103 - No. 1, Jan. 1999- # 842. 316. Sener, O., M.J. Alcordo, H. Y. Lee, N. Ozanguc, & T. J. Yoo. Comparison of the Skin Test Results to Aeroallergens in Ankara and Memphis. JACI, Vol. 103 - No. 1, Jan. 1999- # 48. 317. Du, X, C Wang, T.J. 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Du, X., Nair U., Matsuno, H., and Yoo, T.J., Naked DNA Encoding INF-g Enhances Tubulin Induced Hearing Loss in Guinea Pigs. AAAAI, 2001. 335. Mora, R., Mora, F., Mora, M., Barbieri, A., Barbieri, M., Yoo, T.J. and Mora, E. Recombinant Plasminogen Activator, Actilyse for the Treatment of Sudden Hearing Loss, AAAAI. Mar., 2001. 336. Alcordo, M.J., Nair, U., Kanangat, S. and Yoo, T.J., Nasal Stimulation Alone of Murine Models using Cat Allergen to Elicit an Allergic Response. ACAAI, 2000. 57 337. Cheng, K.C., Matsuoka, H., Kwon, S.S., Suzuki, M., Yazawa, Y., Tanaka, H., Mora, M. and Yoo, T.J., Proto-Oncogene Raf-1 as an Autoantigen in Meniere’s Disease, IFOS Mar., 2001. 338. Kwon, S.S., Kim, N.S., Suzuki, M., Yazawa, Y. and Yoo, T.J. DNA Vaccination for House Dust Mite Allergy Effect of T-Cell Epitope Containing Gene Segment Vaccination. IFOS Mar., 2001. 339. Yoo, T.J., Shea, J. Jr., Yazawa, Y., Matsuoka, H., Tanaka, M., Suzuki, F., Mora, R. and Mora, M., Presence of Autoantibodies in the Sera of Meniere’s Disease. IFOS Mar., 2001. 340. Kim, N.S., Cheng, K.C., Tanaka, H., Suzuki, M., Mora, M., Mora, F., Mora, S. and Yoo, T.J. Oral Tolerance of CB-11 Peptide for Collagen-Induced Chondritus of Mice. IFOS Mar., 2001. 341. Kwon, S.S., Du, X., Yazawa, Y., Suzuki, M., Matsuoka, H., Tanaka, H. and Yoo, T.J. Vaccination with Naked DNA Encoding T-Cell Epitopes of Der P Suppresses Ongoing Der P Induced Allergic Responses. IFOS Mar., 2001. 342. Kim, N.S., Kwon, S.S., Cheng, K.C., Suzuki, M., Yazawa, Y. and Yoo, T.J. DNA Vaccination Suppresses House Dust Mite Allergy. IFOS Mar. 2001. 343. Kim, N.S., won, S.S., Krug, M., Yazawa, Y., Suzuki, M. and Kitajima, K. -Tubulin as an Autoantigen in Meniere’s Disease. IFOS Mar., 2001. 344. Cheng, K.C., Suzuki, M., Krug, M.S., Yazawa, Y., Berstein, J. and Yoo, T.J. Autoantibodies Against Inner Ear Proteins in Patients with Inner Ear Diseases. IFOS Mar., 2001. 345. Matsuoka, J., Kwon, S.S., Suzuki, M., Kitanishi, T., Yazawa, Y. and Yoo, T.J. Endolymphatic Hydrops Induced by Intracochlea Infusion of Monoclonal Antibody Against Type II Collagen CB11 Peptide. IFOS Mar., 2001. 346. Matsuoka, H., Cheng, K.C., Krug, M.S., Suzuki, M., Yazawa, Y., and Yoo, T. J. Murine Model of Autoimmune Hearing Loss with Myelin Protein P0. IFOS Mar., 2001. 347. Fleenor, J.D., Yang, J., Kanangat, S., Du, X., Nair, U., Lee, H., Matsuno, H. and Yoo, T.J. Naked DNA Vaccination of Cockroach (CR) Allergy in Mice. J. Allergy Clin Immunol. Vol 107 No 2: 962, 2000. 348. DU, X., Nair, U., Matsuno, H. and Yoo, T.J. Naked DNA Vaccination Encoding Inf- Enchances Tubulin Induced Hearing Loss in Guinea pigs. Allergy Clin Immunol. Vol 107 No 2: 905, 2000. 349. Moissidis, J, Nair, U, Saeed, A, Kanangat, Mora, R, Barbieri, Yoo, T J, The recombinant tissue plasminogen activator (rtPA) upregulates IL-8 and matrix metalloproteinase I, EAAAI 2001. 350. Yang, J, Parks, A, Moissidis, J, Kanangat, S, Nair, U, Du, X, James, A, Yoo, T J, Naked DNA vaccination of Cockroach (CR) allergy in mice, EAAAI, 2001. 351. Yang, J, Nair, S, Yoo, TJ, Naked DNA vaccination of Cockroach (CR) allergy in mice, ACAAI, 2002. 352. Yang, J, James, A, Nair, U, Yoo, T.J., Naked DNA vaccination of Cockroach (CR) allergy in mice, ACAAI, 2001. 353. Michael, C., Saeed, A., Tarner, I.H., Du, X., Park, Y.D., Yang, J., James, A., Nair, U., Fathman, C.G., Yoo, T.J., IL-12-P-40 gene transduced T-cell hybridomas suppress the induction of collagen-induced auricular chondritis in mice, ACAAI, 2002 58 354. James, A., Saeed, A., Yang, J., Michael, C.F., Du, Park, Y.D., Nair, U., Kanangat, S., Yoo, T.J., Liposome DNA vaccination is more effective than DNA vaccination alone in its suppression on Th2 response in cockroach allergy in mice, ACAAI, 2002. 355. Yang, J., Nair, U., Du, X., Yoo, T.J., Allergic Immune Response Modulation Cockroach Allergy By Genetic Vaccination With Plasmid DNA Encoding Cockroach Allergen In Murine Models, ACAAI, 2002. 356. Michael, C., Saeed, A., Tarner, I.H., Du, X., Park, Y.D., Yang, J., James, A., Nair, U., Fathman, C.G., Yoo, T.J., IL-12-P-40 gene transduced T-cell hybridomas suppress the induction of collagen-induced auricular chondritis in mice, AAAAI, 2002. 357. James, A., Saeed, A., Yang, J., Michael, C.F., Du, Park, Y.D., Nair, U., Kanangat, S., Yoo, T.J., Liposome DNA vaccination is more effective than DNA vaccination alone in its suppression on Th2 response in cockroach allergy in mice, AAAAI, 2002. 358. A. Saeed1, IH Tarner2, CF, Michael1, X DU1, YK Guo1, YD Park1, J Yang1, A James1, U Nair1, CG Fathman2, T.J. Yoo1, Memphis, TN1, Palo Alto, CA2, T-cell Mediated Gene Therapy for CIED in Mice, AAAAI, 2002. 359. Hill, U Nair, S Kanangat, R Mora, TJ Yoo, The Recombinant Tissue Plasminogen Activator (RTPA) Up Regulates IL-8 and Matrix Metallo Proteinase 1, ACAAI, 2003. 1 1 1 2 2 360. Brandon D Hill , Usha Nair , Siva Kanangat , Renzo Mora , Marco Barbieri , 1 1 Mohammad Habiby Kermany , Tai June Yoo , The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, AAAAI, 2003. 1 1 1 1 1 361. Xiaoping Du , Hideo Matsuno , Siva Kanangat , Usha Nair , Weihau Cheng , Brandon 1 1 D Hill, Mohammad Habiby Kermany , Tai June Yoo Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, AAAAI, 2004. 362 Y.K. Guo1, C.X Zhang2, M. Habiby-Kermany1, X. Du3, B.D. Hill 1,T.J. Yoo1, Inner Ear Injury in Apolipoprotein E-deficient (Apo-E-ko) mice, ARO, 2004. 1 1 1 1 1 363.Xiaoping Du , Hideo Matsuno , Siva Kanangat , Usha Nair , Weihau Cheng , Brandon 1 1 1 D Hill , Mohammad Habiby Kermany , Tai June Yoo , Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, ARO, 2004. 364.A Saeed1, IH Tarner2, Brandon Hill1, Y.K. Guo1, X Du1, M. Habiby Kermany1, CG Fathman2, T.J. Yoo1, Memphis TN1, Palo Alto, CA2, T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, ARO, 2004. 365.M. Habiby Kermany1, 2, 4, Y. K. Guo1, 2, 4, T. J. Yoo2, G. M. Rinchik3, D. Goldowitz1, J. Zuo4, A Mouse Mutagenesis Screen to Identify Genes Important for hearing, ARO, 2004. 1 1 1 2 2 366.Brandon D Hill , Usha Nair , Siva Kanangat , Renzo Mora , Marco Barbieri , 1 1 Mohammad Habiby Kermany , Tai June Yoo , The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, ARO, 2004. 1 1 1 2 2 367. Brandon D Hill , Usha Nair , Siva Kanangat , Renzo Mora , Marco Barbieri , 1 1 Mohammad Habiby Kermany , Tai June Yoo , The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, FASEB, 2004. 59 368.A Saeed1, IH Tarner2, Brandon Hill1, Y.K. Guo1, X Du1, M. Habiby Kermany1, CG Fathman2, T.J. Yoo1, Memphis TN1, Palo Alto, CA2, T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, FASEB, 2004. 1 1 1 1 1 369.Xiaoping Du , Hideo Matsuno , Siva Kanangat , Usha Nair , Weihau Cheng , Brandon 1 1 1 D Hill , Mohammad Habiby Kermany , Tai June Yoo , Naked DNA Encoding INFgama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, FASEB, 2004. 370.Y. K. Guo1, C.X Zhang2, M. Habiby-Kermany1, X. Du3, B.D. Hill 1,T.J. Yoo1, Inner Ear Injury in Apolipoprotein E-deficient (Apo-E-ko) mice, FASEB, 2004. 371. Jun Yang1, Alan James1, Abdelwahb Saeed1, Siva Kanangat1, Xiaoping Du1, Usha Nair1, Weihua Cheng1, Tai June Yoo1, Allergy Immune Response is Modulated by DNA Vaccination For Cockroach Allergy In Mice, FASEB, 2004. 372. A Saeed1, IH Tarner2, Y.K. Guo1, X Du1, CG Fathman2, T.J. Yoo1, T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, FOCIS, 2004. 373. Jun Yang1, Alan James1, Abdelwahb Saeed1, Xiaoping Du1, Usha Nair1, Siva Kanangat1, Weihua Cheng1, T. J Yoo1, The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalloproteinase 1 Activities, FOCIS, 2004. 1 1 1 1 1 374. Tai June Yoo , Xiaoping Du , Hideo Matsuno , Siva Kanangat , Usha Nair , Weihau 1 1 Cheng , Tai June Yoo , Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, FOCIS, 2004. 375. Naked DNA Encoding INF-g Enhances Tubulin Induced Hearing Loss in Guinea Pigs Du Xi aoping, Matsuno Hideo, Kanangat Sivadesan, Lee Jaechun, Yoo Tai June IFOS 2005; International federation of otolaryngological society. June 2005, Rome Italy 376. Characterization of immune response in β-tubulin induced murine autoimmune hearing loss. Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Jaechun Lee, Tai June Yoo. 5th Annual International Symposium Meniere's Disease & Inner Ear Homeostasis Disorders. April 2005, Los Angels, CA 377.Induction of hearing loss in mice with β-Tubulin immunization Mohammad. Habiby Kermany, Bin Zhou 379.Immune responses in tubulin induced hearing loss in miceI Habiby Kermany Mohammad, MD. Ph.D; Du Xiaoping, MD; Lee Jaechun, MD., Cai Qing, MD., Yoo Tai june, MD. Ph.D; IFOS 2005; International federation of Otolaryngological society. June 2005, Rome Italy 60 380.Immune response in tubulin induced hearing loss in miceII Bin Zhou, Jonathan Glickstein, Jaechun Lee, Mohammad Habiby Kermany, Tai June Yoo. IFOS 2005; International federation of Otolaryngological society. June 2005, Rome Italy 381.Immune respo nses of tubulin mediated hearing loss in mice. Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Jaechun Lee, Tai June Yoo I.E.B. (inner ear Biology Meeting) Sept. 2005, Tubingen, Germany 382.The Therapeutic Effect of the Co-Administration of Immunostimulatory DNA Sequence with Allergen Extract on Allergic Inflammation in Animal Model of Timothy Allergy. Jun Woo Kim, Jaechun Lee, Brandon D. Hill, Tai June Yoo (ARO 2006 ) Baltimore, MD 383. Restoration of Immune Mediated Hearing Loss by Adoptive Cellular Gene Therapy. Bin Zhou, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Wenxia Liu, Jun Woo Kim, Patrick Kim, Ingo Tarner, Garner Fathman, Tai June Yoo (ARO 2006 ) Baltimore, MD 384. Characterization of Immune Response in I2 – Tubulin Induced Murine Autoimmune Hearing Loss. Chun Cai, Bin Zhou, Jonathon Glickstein, Tai June Yoo (ARO 2006) Baltimore, MD 385. Oral Administration of Low Dose a- Tublin Decreases Autoimmune Hearing Loss Lesion in the Mice. Qing Cai, Tai June Yoo (ARO 2006) Baltimore, MD 386. Indentification of 12 Mutant Mouse Strains with High Frequency Hearing Loss in the TMGC ENU Mutagenesis Screen. Mohammad Habiby Kermany, Lisan Parker, Yn-Kai Guo, Darla Miller, D.J. Swanson, Tai June Yoo, Daniel Goldowitz, Jian Zuo (ARO 2006) Balitmore, MD 387. Auditory Brainstem Responses and Distortion Products of Oto-Acoustic Emission in Mouse Autoimmune Hearing Loss. Mohammad Habiby Kermany, Michael Yoon, Bin Zhou, Tai June Yoo (ARO 2006) Baltimore, MD 388. Oral Administration Decreases Autoimmune Hearing Loss Lesion in the Mice. Qing Cai, Tai June Yoo (AAAAI 2006) Miami, FL 389. ABR and DPQAE in Tubulin Based Induced Autoimmune Hearing Loss. Muhammad Habiby Kermany, Bin Zhou, Michael Yoon, (AAAAI 2006) Miami, FL 390. Characterization of Immune Response in - Tublin induced Murine Autoimmune Hearing Loss. C.Cai, B. Zhou, J. Glickstein, T.J. Yoo (AAAAI 2006) Miami, FL 391. Mast Cell Derived Plasminogen Activator Inhibitor- 1 in the Airways of a Murine Asthma Model and its Regulation by Cysteinyl Leulotrienes. S.H. Chou, J.A. Boyce, T.J. Yoo, C.K. Oh (AAAAI 2006) Balimore, MD 61 392. Therapeutic Use of The Co-Administration of Immunostimulatory DNA Sequence with Allergen Extract in a Mouse Model of Timothy Allergy. J.W. Kim, J.Lee, T. J. Yoo (AAAAI 2006) Baltimore, MD 393. Restoration of Immune Mediated Hearing Loss by Adoptive Cellular Gene Therapy T.J. Yoo, B.Zhou, M. Kermany, C. Cai, Q. Cai, P. Kim, J. Kim (AAAAI 2006) Baltimore, MD 394. DNA Vaccine Restores Hearing Loss Induced by -Tublin in Guinea Pig. J. Zhang, B. Zhou, Q. Cai, P. Kim, T.J. Yoo (AAAAI 2006) Miami, FL 395. Characterization of The Protective and Therapeutic Efficiency of a DNA Vaccine Encoding The Cockroach Allergen Bla g 1. B. Zhou, M. Ensell J. Glickstein, C. Cai, M. Kermany Q. Cai, T.J. Yoo (AAAAI 2006) Baltimore, MD 396. Murine autoimmune hearing loss mediated by CD4+ T cells specific for -tubulin Bin Zhou, Jonathan Glickstein, Jaechun Lee, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Tai June Yoo.(AAI2006) 397. Restoration of Immune Mediated Hearing Loss by Adoptive Immunotherapy B. Zhou1, M. Habiby Kermany1, C. Cai1, Q. Cai1, IH. Tarner2, C.G. Fathman2, P. Kim1, J.W. Kim1, T.J. Yoo1. (AAI2006) 399. Murine autoimmune hearing loss mediated by CD4+ T cells specific for -tubulin Bin Zhou, Jonathan Glickstein, Jaechun Lee, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Tai June Yoo. 400. Induction of tolerance in the animal model of autoimmune inner ear disease by oral administration of -tubulin. Qing Cai, Bin Zhou, Chun Cai, Mohammand Habiby Kemany, Jun Woo Kim, Jun Zhang, Tai June Yoo 401. Auditory brainstem responses and Distortion products of otoacoustic emissions in mouse autoimmune hearing loss Mohammad Habiby Kermany; Michael Yoon; Bin Zhou; Tai June Yoo; 402. Identification of 12 mutant mouse strains with high-frequency hearing loss in the TMGC ENU-mutagenesis screen Mohammad Habiby Kermany1,2, Lisan Parker1, Yun-Kai Guo1,2, Dan Goldowitz3, Jian Zuo1Tai-June Yoo2, 403. Inner Ear Injury In Apolipoprotein E-Deficient (Apo-E-ko) Mice Y.K. Guo, C. X. Zang, M. Habiby-Kermany, X. Du, T.J. Yoo, 404. Naked DNA Encoding INF- Enhances Tubulin Induced Hearing Loss In Guinea Pigs Youm Yee Kim, Xiaoping Du, Hideo Matsuno, Sivadesan Kanangat, , Taijune Yoo 62 405. T-Cell Medicated Gene Therapy for Collagen-Induced Ear Disease (CIED) In Mice A. Saeed, IH Tarner, Y.K. Guo, X Du, C.G Fathman, T.J. Yoo, 406. Restoration of Immune Mediated Hearing Loss by Adoptive Cellular Gene Therapy. AAI 2008 Annual Meeting, San Diego. Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Wenxia Liu, Jun Woo Kim, Patrick Kim, Tai June Yoo. 407. β-tubulin-induced Autoimmune Hearing Loss Exacerbates in IL-10-deficient Mice and Restores by IL-10 Gene Transfer Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Qing Cai, Chun Cai, Wenxia Liu, Jun Woo Kim, Patrick Kim, Tai June Yoo.. FOCIS 2007 San Diego. 408. Bin Zhou, Jonathan Glickstein, Yixuan Zhou, Mohammad Habiby Kermany, Chun Cai, Qing Cai, Jun Woo Kim, Patrick Kim, Wenxia Liu, and Tai June Yoo. Characterization of Immune Response in β-tubulin Induced Murine Experimental Autoimmune Hearing Loss. AAI 2007 Annual Meeting, Miami Beach. Poster presentation. 409. Restoration of hearing with DNA vaccine or cellular gene therapy in immune mediated hearing loss. Yoo , T.J. ,Zhou B., Kermany M.H. ., Cai Q, Cai ,C, Tarnar I.H., Kim ,J. W. XXX Barany Society Meeting, Kyoto, Japan, March 31 - April 3, 2008. 410. Therapeutic effect of the co-adminstration of immunostimulatory DNA sequence with timothy allergen in mice. Jun Woo Kim, Jaechun Lee, Brandon D. Hill, Tai June Yoo. Thailand(2007) 411. Sensorineural hearing loss and autoimmunity, M. Habiby Kermany, B. Zhou, C. Cai, Q. Cai, T. Yoo; 37th Neuroscience annual meeting, San Diego, California, November 37, 2007 412. Induction of tolerance in the animal model of autoimmune inner ear disease by oral administration of Beta-tubulin, Q. Cai, B. Zhou, M. Habiby Kermany, C. Cai, T. Yoo; 37th Neuroscience annual meeting, San Diego, California, November 3-7, 2007. Poster presentation. 413. Beta-tubulin induces auto-immune inner ear disease, Mohammad Habiby Kermany, Bin Zhou, Cai Chun, Xiaoping Du, Tai June Yoo, ARO association for research in Otolaryngology mid winter meeting February 11-15/2007. 414 Effect of Immunotherapy with ISS-ODN in animal modelmof Mugwort Aqllergy. J.Jim,J.Lee,B. Hill,S.Kim,B.Zhou,T.J.Yoo,ACAAI,nov Dallas Tx. 415. The role of PAI-1 polymorphism in idiopathic sudden hearing loss. S.Cho,C.Cai,A.Martini,T Yoo., ACAAI Nov Dallas,Tx. 63 416 Murine experimental autoimmune hearing loss mediated by CD4+ T cells and antibodies specific for β-tubulin. Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Chun Cai, Qing Cai, Yixuan Zhou, Jun Woo Kim, Patrick Kim, Wenxia Liu, Tai June Yoo. 417 β-tubulin-induced autoimmune hearing loss exacerbates in IL-10-deficient mice and restores by IL-10 gene transfer, Bin Zhou, Jonathan Glickstein, Mohammad Habiby Kermany, Chun Cai, Qing Cai, Yixuan Zhou, Jun Woo Kim, Patrick Kim, Wenxia Liu, Tai June Yoo.Focis,San Diego 2007 418 ß-tubulin induced Murine Model of Autoimmune Hearing Loss and Regulation of Tcell Cytokaines of the Mice, B. Zhou, J. Glickstein, M. Habiby Kermany, C. Cai, Q. Cai, W. Liu, Tai June Yoo,2007 American Academy of Allergy, Asthma & Immunology (Annual Meeting, February 23-27,. The Journal of Allergy and Clinical Immunology, Jan 2007, Vol 119, No.1 P. S17 419 ß-tubulin induces auto-immune inner ear disease, Mohammad Habiby Kermany, Bin Zhou, Cai Chun, Xiaoping Du, Tai June Yoo, ARO association for research in Otolaryngology mid winter meeting February 11-15/2007. Poster presentation. 420 Adoptive Immunotherapy of Experimental Autoimmune Hearing Loss Via T Cell Delivery of the IL-12 p40 Subunit, Bin Zhou, Mohammad Habiby Kermany, Chun Cai, Qing Cai, Tai June Yoo, ARO association for research in Otolaryngology mid winter meeting February 11-15/2007. Poster presentation. 421 inflammation in the murine model of house dust mite allergy, Tai June Yoo , Nacksung Kim, Soon Seog Kwon, Jaechun Lee, Sohyung Kim, Poster presentation. Allergome meeting , Rome, Italy,2007 421 β-tubulin Induced Murine Model of Autoimmune Hearing Loss and Regulation of T Cell Cytokines of the Mice, S. H. Cho, B. Zhou, J. Glickstein, M. Habiby Kermany, C. Cai, Q. Cai,W. Liu, T. J. Yoo; Journal of Allergy and Clinical Immunology, Volume 119, Issue 1, Supplement 1, AAAAI January 2007, Page S17 422 Induction of specific Th1 responses and suppression of IGE antibody formation and airway eosinophilia by vaccination with plasmid DNA encoding Blag 1 . The third international conference on DNA Vaccines meeting , 2007,Malaga Spain 423 Treatment and prevention pof neurodegerative diseases using gene therapy,T.J.Yoo. Seoul national University college of medicine annual meeting in Las Vegas, 2008 424 DNA vaccine for Alzheimer’s disease, Neuroscience meeting, 2008. WashingtonDC 425 DNA vaccine for Salaheimer’s disease, International conference of DNA vaccine, Las Vegas 2008 64 426 DNA vaccine update, SNU CM summerconference 2009 427 Stem cell therapy , SNU CM summer conference 2009 428 Adoptive cellular gen ethrapy restore hearing in autoimmune hearin gloss model , AAAAI meeting,Washington DC, 2009 429. Blag1 DNA vaccine ameeriorate cockroach allergy in mice,AAAAI meeting , Washington DC. 430. Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. Bin Zhou, Jingdong Yuan, Yixuan Zhou, Austin J. Lee, Albert J, Lee, Maher Ghawji Jr., Usha Nair, Andrew H. Kang, David D. Brand, Tai June Yoo. 2010 IFAT meeting, Dallas TX 431. The therapeutic efficacy of human adipose tissue-derived mesenchymal stem cells on experimental autoimmune hearing loss in mice. Yixuan Zhou, Jingdong Yuan, Austin J. Lee, Albert J, Lee, Maher Ghawji Jr. David D. Brand, Bin Zhou, Tai June Yoo. 2010 IFAT meeting, Dallas TX 432. The effect of adipose stem cell on survival in a model of Graft versus Host Disease. Jingdong Yuan, Yixuan Zhou, Austin J. Lee, Albert J, Lee, Maher Ghawji Jr. David D. Brand, Bin Zhou, Tai June Yoo. 2010 IFAT meeting, Dallas TX 433. The DNA vaccine for Alzheimer’s disease 2011 Gene Therapy conference,Beijing China 434. 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A Family Study of HL-A Antigen and Immune Response (Ir) Gene Linkage in Ragweed and Dust Allergy. Thirty-second Annual meeting of the American Academy of Allergy, March 1976. San Juan, Puerto Rico. 28. A Study of Growth and Rat Hepatoma: The Effect of Pre-immunization of Tumor Antigen and Tumor Cell. FASEB 60th Annual Meeting, April 1976. Anaheim, California. 29. A Family Study of HL-A Antigen and Ir Gene Linkage in Ragweed and Dust Allergy. FASEB 60th Annual Meeting, April 1976. Anaheim, California. 30. The Effect of Allergenic Stimulation on the Growth of Rat Hepatoma. NorthCentral Allergy Conference, May 1976. Rochester, Minnesota. 31. Lymphocyte Transformation in Dust Allergy. North-Central Allergy Conference, May 1976. Rochester, Minnesota. 32. A Study of Allergenic Stimulation on the Growth of Rat Hepatoma. University of Iowa College of Medicine Research Day II, May 1976. Iowa City, Iowa. 33. A Family Study of HL-A Antigen and Immune Response (Ir) Gene Linkage in Ragweed and Dust Allergy. University of Iowa College of Medicine Research Day II, May 1976. Iowa City, Iowa. 34. The Effect of Allergenic Stimulation on the Growth of Rat Hepatoma. 67th Annual meeting of the American Association for Cancer Research, May 1976. Toronto, Canada. 35. Serum Immunoglobulin Concentrations in Carcinoma of the Head and Neck. Third International Symposium of Detection and Prevention of Cancer. New York, New York, April 1976. 36. A Family Study of HL-A Antigen and Ir Gene-Linkage in Ragweed and Dust Allergy. First International Symposium on HL-A and Disease, June 1976. Paris, France. 37. A Family Study of HL-A Antigen and Ir Gene Linkage in Ragweed and Dust Allergy. Department of Microbiology, University of Hawaii, August 1976. 38. Genetic Control of Human Allergic Diseases. Munson Army Hospital, Ft., Leavenworth, Kansas, August 1976. 39. Genetic Control of Human Allergic Diseases. University of Kansas Medical Center, Kansas City, Kansas, August 1976. 40. In Vitro Inhibition of H-thymidine Uptake in Morris Hepatoma Cells by Normal Rat Liver Extract. A Possible Liver Chalone. April 1977, FASEB, Chicago. 41. Cellular and Reaginic Immune Responses to Ragweed Antigen E (AgE) in Inbred Rats. February 1977, American Academy of Allergy, New York. 42. In Vitro and Vivo Studies of Morris Hepatoma. University of Kansas Medical Center, Kansas City, Kansas, December 1977. 43. Mechanism of Immunotherapy: Role of Suppressor Cell. University of Kansas Medical Center, Kansas City, Kansas, December 1977. 44. In Vitro and Vivo Studies of Morris Hepatoma. University of California, San Francisco, California, January 1978. 67 45. Control of Oncofetal Antigen Production as an Epiphenomenon of Tumorigenesis. A Medical Symposium on the Production by Malignant Tissue of Tumor Antigens, Hormones, and Enzymes. University of California, Berkeley. 46. The Effect of Glucocorticoids on the Production of Alphafetoprotein, Lactic Dehydrogenase and Malate Dehydrogenase in Morris Hepatoma 7777 In Vitro. A Medical Symposium on the Production by Malignant Tissue of Tumor Antigens, Hormones, and Enzymes. University of California, Berkeley. 47. Concanavalin A-induced Suppressor Cells in Ragweed Allergy. American Academy of Allergy, Annual Meeting, New Orleans, Louisiana. 48. Partial Purification of Active Allergenic Components from Alternaria. American Academy of Allergy, Annual Meeting, New Orleans, Louisiana. 49. Mitogenesis-Enhancing Adherent Cells in a Rat Mammary Adenocarcinoma. The American Association of Immunologist, Dallas, Texas. 50. Effect of Fatty Acid Modification on Immunocytolysis of Hepatoma Cells. The American Association of Immunologists, Dallas, Texas. 51. Control of Oncofetal Antigen Production as an Epiphenomenon of Tumorigenesis. The American Association of Immunologists, Dallas, Texas. 52. Mechanisms of Tumor Metastasis. To "Oncology Groups" Seoul National University Hospital, Seoul, Korea, July 1978. 53. Tumor Antigen, Cell Membrane and Metastasis. A special lecture to Korean Association of Immunologists, Seoul, Korea, July 1979. 54. Fatty Acid Modification of Tumor Cell and Effect on Immune Cytolysis. Department of Microbiology, Seoul National University, Seoul, Korea, July 1979. 55. Membranes as a Key Player in Immune Phenomena. Catholic Medical College and St. Mary's Hospital, Seoul, Korea, July 1979. 56. Aspect of Neurologic Disorders. Department of Neurology, Seoul National University, Seoul, Korea, July 1979. 57. Mechanism of Immunotherapy: Role of Suppressor Cells. Department of Medicine, Seoul National University, Seoul, Korea, July 1979. 58. Mechanism of Immunotherapy: Role of Suppressor Cells and Antigen Modification. Joint symposium of Korean Medical Association and Korean Medical Association in America. Seoul, Korea, July 1979. 59. Mechanism of Tumor Metastasis. Hematology-Oncology Service, Brooke Army Medical Center, San Antonio, Texas, April 1979. 60. Role of Suppressor Cells in Immunotherapy. Allergy-Immunology Service, Brooke Army Medical Center, San Antonio, Texas, April, 1979. 61. Partial Purification of Alternaria Allergy and Immunotherapy. AllergyImmunology Service, Brooke Army Medical Center, San Antonio, Texas, April 1979. 62. Con-A Induced Suppressor Cell in Ragweed Allergy. Immunology-Allergy Division, Department of Pediatrics, University of Texas, San Antonio, Texas, April 1979. 63. Fatty Acid Modification of Tumor Cells Can Effect Immune Cytolysis. Immunology-Allergy Division, Pediatrics Department, University of Texas, San Antonio, Texas, April 1979. 68 64. Basic Immunology. Medical Service, V.A. Medical Center, Des Moines, Iowa, 1979. 65. Biology of Tumor Metastasis. Department of Pathology, Mercy Medical Center, Des Moines, Iowa, 1979. 66. Immunologic Basis of Allergic Disease. Medical Service, V.A. Medical Center, Des Moines, Iowa, 1979. 67. Cancer Immunology. Medical Service, V.A. Medical Center, Des Moines, Iowa, 1979. 68. Immune Deficiency Diseases and Their Evaluation and Therapy. Medical Service, V. A. Medical Center, Des Moines, Iowa, 1979. 69. Pulmonary Diseases with Immunologic Manifestation. Medical Service, V.A. Medical Center, Des Moines, Iowa, 1979. 70. Modification of Fatty Acid Composition of Cultured Hepatoma Cells and Their Susceptibility to Immune Cytolysis. Federation of American Societies for Experimental Biologists Annual Meeting, Anaheim, California, 1980. 71. A New Allergen from Alternaria Tenius. Federation of American Societies for Experimental Biologists Annual Meeting, Anaheim, California, 1980. 72. Cytotoxic Studies of Metastasizing Rat Mammary Adenocarcinoma. Federation of American Societies for Experimental Biologists Annual Meeting, Anaheim, California, 1980. 73. Cytotoxic Studies of Metastasizing Rat Mammary Adenocarcinoma. Fourth International Congress of Immunology of the International Union of the Immunological Societies, Paris, France, 1980. 74. Effect of Fatty Acid Modifications of Cultured Hepatoma Cells of Susceptibility to Complement Mediated Cytolysis. Fourth International Congress of Immunology of the International Union of Immunological Societies, Paris, France, 1980. 75. Molecular Immunology in Allergy. University of Tennessee Center for the Health Sciences, Memphis, Tennessee, 1980. 76. Immunologic Mechanism of Tumor Metastasis. Veterans Administration Medical Center, Memphis, Tennessee, 1981. 77. Immunologic Basis of Anaphylaxis and Anaphylactoid Reaction. VA Medical Center, University of Tennessee Center for the Health Sciences, 1981. 78. Diagnosis and Treatment of Bee Sting Allergy. University of Tennessee Center for the Health Sciences, 1981. 79. Effect of Membrane Fatty Acid Modification on Natural Killer Cells. LeBonheur's Hospital, Memphis, Tennessee, 1981. 80. Natural Killer Cells and Target Cell Membrane Composition. St. Jude Hospital, 1981. 81. Immunologic Mechanism in Sensory-Neural Hearing Loss "What's New in Otology Today". Shea Clinic Annual Otology Conference, 1981. 82. Chiu, C.H., Cazin, J., Kuo, C.Y., Roger, G., Chung, T.W., Lieberman, P., Crawford, L., and Yoo, T.J.: Allergic Properties of Different Sources of Alternaria Antigens. American Academy of Allergy, San Francisco, 1981. 69 83. Lieberman, P., Lewis, J., Treadwell, G., Erffmeyer, J., Taylor, W., Yoo, T.J., Gatewood, J., and Siegle, R.: Exercise Induced Urticaria, Angioedema, and Anaphylaxis. American Academy of Allergy, March 1981. 84. Kuo, C.Y., Song, A.S., and Yoo, T.J.: Anti-tumor Immunity to L5178Y Lymphoma in Syngeneic Mice. AACR, 1981. 85. Kuo, C.Y., Song, A.S., and Yoo, T.J.: Possible Role of Shredded Fc Receptor in Tumor Cell Escape. FASEB, Atlanta, CA, 1981. 86. Floyd, R., Kuo, C.Y., Garcia, M., Song, A.S., Postlethwaite, A.R., Kang, A.H., Tomoda, K., and Yoo, T.J.: Effect of Protease Inhibitors on NK and ADCC Activities. FASEB, Atlanta, GA, 1981. 87. Floyd, R.A., Chiang, T.M., Kuo, C.Y., Stone, G., Postlethwaite, A.R., Kang, A.H., Tomoda, K., and Yoo, T.J.: Effect of Sunflower and Coconut Oil Diets on Immune Responses in DBA/2 Mice and W/FU Rats. FASEB, 1982. 88. Yoo, T.J., Tomoda, K., Stuart, J., Kang, A.H., Cremer, M.A., and Townes, A.: Collagen-Induced Autoimmune Neurosensory Hearing Loss, Vestibular 89. Stuart, J.M., Yoo, T.J., Kang, A.H., Townes, A.S., Tomoda, K., Dixit, S.N.: Collagen Autoimmunity as a Cause of Otosclerosis. FASEB, 1982. 90. Kuo, C.Y., Budd, T.W., Budd, C., Hsu, P.W., Yoo, T.J., and Patil, S.R.: Loss of Tumorigenicity in a Long-Term Myeloid Leukemic Cell Culture: Possible NKCell Mediated Surveillance. FASEB, 1982. 91. Budd, T.W., Kuo, C.Y., Yoo, T.J., and Cazin, J.: Isolation of a Unique Basic Peptide Allergen from Alternaria Extract. FASEB, 1982. 92. Budd, T.W., Kuo, C.Y., Yoo, T.J., and Cazin, J.: The Isolation of a Unique Basic Peptide Allergen from Alternaria Extracts. American Academy of Allergy 1982. 93. Yoo, T.J., Tomoda, K., Stuart, J., Kang, A.H., Cremer, M., and Townes, A.: Collagen-induced Autoimmunity Neurosensory Hearing Loss, Vestibular Dysfunction, and Otosclerosis in Rodents. Abstract 61, Mid-Winter ARO. 94. Yoo, T.J., Stuart, J.M., Kang, A.H., Townes, A.S., and Tomoda, K.: Collagen Autoimmunity as a Cause of Otosclerosis and Meniere's Disease. Abst. 121 Midwinter ARO, 1982. 95. Angioneurotic edema; Current Concept. University of Tennessee Center for the Health Sciences, 1982. 96. Immunology of Autoimmune Hearing Loss. University of Tennessee Center for the Health Sciences, 1982. 97. Anaphylaxis and Anaphylactoid Reacting: Modern Concept. U.S. Army Community Hospital, Seoul, Korea, August 1982. 98. An Approach to Anaphylaxis and Anaphylactoid Reaction. Han-Yang University Medical Center, Seoul Korea, 1982. 99. Autoimmunity and Hearing Loss: A New Concept Special Service. Korea Advanced Institute of Science and Technology, August 1982. 100. Hearing Loss: An Immunologic Approach. Guest Speaker: Korean Association of Immunologist, August 1982. 101. Update Autoimmune Sensorineural Hearing Loss. Shea Clinic Annual Otology Conference, 1982. 102. Current Concept of Autoimmune Sensorineural Hearing Loss. First International Oto-Immunology Think Tank Meeting, Palm Beach, FL, 1982. 70 103. Panel Member; Autoimmune Sensorineural Hearing Loss, First International Inner Ear Surg. Symposium, Colorado, 1982. 104. Yoo, T.J., Tomoda, K., and Cremer, M.: Type II Collagen Induced Autoimmune Spongiosis-like Lesions and a New Hypothesis for the Pathogenesis of Otospongiosis. Fall, ARO, 1982. 105. Yoo, T.J., Yazawa, Y., Cremer, M., Tomoda, K., and Floyd, R.: Antibody Activity Against Type II Collagen in the Inner Fluid from Type II Collagen Induced Autoimmune Inner Ear Disease in Guinea Pigs and Rats. ARO, Fall 1982. 106. Tomoda, K. and Yoo, T.J.: Type II Collagen Induced Autoimmune Salpingitis. ARO, Fall 1982. 107. Yoo, T.J., Tomoda, K., and Hernandez, A.: Type II Collagen Induced Autoimmune Inner Ear Disease in the Guinea Pig. ARO, Fall 1982. 108. Yoo, T.J., Oh, J.H., Floyd, R., Shea, J.J., and Tomoda, K.: A Suggestive Linkage of HLA-DR4 Loci in Otosclerosis Patients. ARO, Fall 1982. 109. Invited guest speaker, Autoimmune Mechanism in Sensorineural Hearing Loss, Third International Symposium Tinnitus, New York, NY, June 1983. 110. Invited guest speaker on Autoimmune Salpingitis, Third International Symposium on Otitis Media with Effusion, Ft. Lauderdale, Fl, May 1983. 111. Tomoda, K. and Yoo, T.J.: Type II Collagen Distribution in the Inner Ear. ARO Midwinter Conference, St. Petersburg, FL, 1983. 112. Yoo, T.J. and Tomoda, K.: Type II Collagen Distribution in the External and Middle Ears. ARO Midwinter COnference, St. Petersburg, FL, 1983. 113. Yoo, T.J.: Autoimmune Ear Disease. Tajik State Medical Institute, Duhsanbe, USSR, 1983. 114. Yoo, T.J.: Type II Collagen Induced Autoimmune Salpingitis in Rat. 3rd Int'l. Symposium on Recent Advances in Otitis Media, 1983. 115. Yoo, T.J.: Autoimmune Sensorineural Hearing Loss-Animal Model Update and a Hypothesis of Etiopathogenesis-A Possible Tinnitus Model. 2nd Int'l. Seminar on Tinnitus, 1983. 116. Yoo, T.J.: Etiopathogenesis of Autoimmune Disease. 7th Joint Scientific meeting of the Korean Medical Association of America. 117. Yoo, T.J.: Autoimmune Ear Disease. Dept. of Otolaryngology, Seoul University, Seoul, Korea, 1983. 118. Yoo, T.J.: Autoimmune Ear Disease. Korea Advanced Institute of Science and Technology, Seoul, Korea, 1983. 119. Yoo, T.J.: Autoimmune Ear Disease. Kansai Medical University, Osaka, Japan, 1983. 120. Kuo, C.Y., Yoo, T.J., Seyer, S., Taylor, W.W. and Chung, T.W.: Alternaria Allergens: Comparative Studies of the Basic and Acidic Components. 5th Int'l. Congress of Immunology, 1983. 121. Yoo, T.J. and Tomoda, K.: Type II Collagen-Induced Autoimmune SpongiosisLike Lesions and a New Hypothesis for the Pathogenesis of Otospongiosis. 5th Int'l. Congress of Immunology, 1983. 122. Yoo, T.J., Yazawa, Y., and Tomoda, K.: Type II Collagen Autoimmunity and Meniere's Disease. 5th Int'l. Congress of Immunology, 1983. 71 123. Yazawa, Y., Floyd, R., Tomoda, K., and Yoo, T.J.: Antibody Activity Against Type II Collagen in the Inner Ear Fluid form Autoimmune Inner Ear Disease in Guinea Pigs. 5th Int'l. Congress of Immunology, 1983. 124. Yoo, T.J., Tomoda, K., Yazawa, Y., Floyd, R., and Kang, A.H.: Production of Endolymphatic Hydrops of Type II Collagen and Meniere's Disease. ARO, Anaheim, CA., 1983. 125. Yoo, T.J., Tomoda, K., Yazawa, Y., Floyd, R., and Ishibe, T.: Cell Transfer of Collagen Induced Autoimmune Ear Diseases. ARO, Anaheim, CA., 1983. 126. Ishibe, T., Yoo, T.J., Yazawa, Y., Tomoda, K., Shea, J.J., Cremer, M., and Kang, A.H.: Type II Collagen Distribution in the Fetus Ear. ARO, Anaheim, CA, 1983. 127. Yoo, T.J.: A Hypothesis of Etiopathogenesis and Mechanisms of Attack in Meniere's Disease. ARO, Midwinter, St. Petersburg, FL., 1984. 128. Yoo, T.J., Yazawa, Y., FLoyd, R., and Ishibe, T.: Serum Transfer of Collagen Induced Autoimmune Ear Disease in Rats. Midwinter ARO, St. Petersburg, FL., 1984. 129. Yoo, T.J., Yazawa, Y., Ishibe, T., Floyd, R., Sudo, N., and Kuo, C.Y.: Type II Collagen Induced Inner Ear Disease in Chinchilla. Midwinter ARO, St. Petersburg, FL., 1983. 130. Yoo, T.J., Sudo, N., Ishibe, T., Yazawa, Y., and Floyd, R.: Effect of Steroid Hormone and Sulindac on Collagen Induced Autoimmune Ear Disease (CIAED). Midwinter ARO, St. Petersburg, FL., 1984. 131. Yoo, T.J., Yazawa, Y., Ishibe, T., Tomoda, K., and Floyd, R.: Type II Collagen Induced Tympanosclerosis in Guinea Pigs. Midwinter ARO, St. Petersburg, FL., 1984. 132. Yoo, T.J.: Immunological Basis of Meniere's Disease. British Otolaryngological Research Society Spring Meeting, The Netherlands, 1984. 133. Yoo, T.J.: Immunologically Induced Temporal Bone Lesion. Int. Academic Conference in Immuno. and Immuno-Path. as Applied to Oto. and Rhino., Utrecht, The Netherlands, 1984. 134. Yoo, T.J., L Collagen Autoimmunity and Collagen Induced Arthritis in NonHuman Primate. Danish Otorhinolaryngological and Rheumatological Society, Copenhagen, Denmark, 1984. 135. Yoo, T.J.: Immunologically Induced Temporal Bone Lesions. Seoul National University, Seoul, Korea, 1984. 136. Yoo, T.J.: Immunologically Induced Temporal Bone Lesions. Catholic University Medical School, Seoul, Korea, 1984. 137. Yoo, T.J.: Immunology of the Inner Ear. Kansai Medical School, Osaka, Japan, 1984. 138. Schiff, M. and Yoo, T.J.: Autoimmune Ear Diseases. Trilogy Meeting, West Palm Beach, FL., 1984. 139. Yoo, T.J., Visiting Professor, July 1984, Dept. of Otolaryngol. Kyoto, Japan. 140. Yoo, T.J., Eustachian tube function in physiology and role in otitis media, September 1984, University of Pittsburgh, PA. 141. T.J., Sudo, N., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Type II Collagen-Induced Autoimmune Endolymphatic Hydrops. American Association of Immunologists Meeting, Anaheim, CA, April 1985. 72 142. Sudo, N., Floyd, R., Ishibe, T., and Yoo, T.J.: Cell Transfer of Collagen-Induced Autoimmune Ear Diseases in Guinea Pigs. American Association of Immunologists Meeting, Anaheim, CA, April 1985. 143. Floyd, R., Cremer, M., Sudo, N., Takeda, T., Ishibe, T., and Yoo, T.J.: Induction of Tolerance to Type II Collagen Autoimmune Ear Disease in Rats. American Association of Immunologists Meeting, Anaheim, CA, April 1985. 144. Yazawa, K., Sudo, N., Ishibe, T., Takeda, T., Floyd, R., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. American Association of Immunologists Meeting, Anaheim, CA, April 1985. 145. Hue, S.H., Kim, H.Y., Floyd, R.A., and Yoo, T.J.: Modified Alternaria Allergen Immunotherapy in Mice. American Association of Immunologists Meeting, Anaheim, CA, April 1985. 146. Yoo, T.J., Stuart, J.M., Takeda, T., Sudo, N., Floyd, R., Ishibe, T., Olson, G., Orchik, D., Shea, J.J., and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in monkey. AAACI Meeting, New York, New York, 1985. 147. Takeda, T., Orchik, D., Floyd, R.A., Ishibe, T., Sudo, N., Yazawa, Y., Olson, G., Shea, J.J., and Yoo, T.J.: Electrocochleographic Study of Non-Human Primates with Collagen-Induced Ear Disease. Midwinter ARO Meeting, Clearwater, Florida, 1985. 148. Takeda, T., Stuart, J.M., Floyd, R.A., and Yoo, T.J.: Auditory Brain Stem Response (ABR) in Rodents with Type II Collagen-Induced Autoimmune Ear Diseases. Midwinter ARO Meeting, Clearwater, Florida, 1985. 149. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., and Ishibe, T.: Type II CollagenInduced Autoimmune Endolymphatic Hydrops. Midwinter ARO Meeting, Clearwater, Florida, 1985. 150. Yoo, T.J., Sudo, N., FLoyd, R., Ishibe, T., and Tomoda, K.: Type II CollagenInduced Autoimmune Salpingitis in the Rat. Midwinter ARO Meeting, Clearwater, Florida, 1985. 151. Sudo, N., Yazawa, Y., Ishibe, T., Takeda, T., FLoyd, R.A., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. Midwinter ARO Meeting, Clearwater, Florida, 1985. 152. Ishibe, T., and Yoo, T.J.: Type II Collagen Distribution in the Monkey Ear. Midwinter ARO Meeting, Clearwater, Florida, 1985. 153. Ishibe, T., Yoo, T.J., Shea, K., and Tomoda, K.: Immunohistochemical Studies in Meniere's Disease, Otosclerosis and Tympanosclerosis. Midwinter ARO Meeting, Clearwater, Florida, 1985. 154. Ishibe, T., Choe, I.S., Yoo, T.J.: Type II Collagen Development in the Embryonic Chick Ear. Midwinter ARO Meeting, Clearwater, Florida, 1985. 155. Ishibe, T., Tomoda, K., and Yoo, T.J.: Type II Collagen in the Human and Monkey Ear. World Cong. of Oto. Rhino. Laryn., Miami, Florida, May, 1985. 156. Sudo, N., Tomoda, K., Floyd, R., Ishibe, T. and Yoo, T.J.: Type II CollagenInduced Autoimmune Salpingitis in the Rat. World Cong. of Oto. Rhino. Laryn., Miami, Florida, May, 1985. 73 157. Takeda, T., Orchik, D., Floyd, R., Ishibe, T., Sudo, N., Yazawa, Y., Olson, G., Shea, J.J., and Yoo, T.J.: Electrocochleographic Study of Non-Human Primates with Collagen-Induced Ear Disease. World Cong. Oto. Rhino. Laryn., Miami, Florida, May, 1985. 158. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R., and Ishibe, T.: Type II CollagenInduced Autoimmune Endolymphatic Hydrops. World Cong. of Oto. Rhino. Laryn., May, 1985. 159. Yazawa, Y., Yoo, T.J., Ishibe, T. and Tomoda, K.: Type II Collagen-Induced Tympanosclerosis Model in Guinea Pigs. World Cong. Otol. Rhino. Laryn. May 1985. 160. Yoo, T.J., Cremer, M., Sudo, N., Takeda, T., Floyd, R., and Ishibe, T.: Induction of Tolerance to Type II Collagen Autoimmune Disease in Rats. World Cong. Otol Rhino. Laryn., May, 1985. 161. Ishibe, T., Choe, I.S., and Yoo, T.J.: Type II Collagen Development in the Embryonic Chick Ear. World Cong. Oto. Rhino. Laryn., May 1985. 162. Ishibe, T., Tomoda, K., Yoo, T.J., Shea, J.J., and Causse, J.B.: Immunochemical Studies in Meniere's Disease, Otosclerosis, and Tympanosclerosis. World Cong. Oto. Rhino. Laryn., May, 1985. 163. Sudo, N., Yazawa, Y., ishibe, T., Takeda, T., Floyd, R., and Yoo, T.J.: Histological Studies of the Temporal Bones of Systemic Lupus Erythematosus (SLE) Prone Murine Strains. World Cong. Oto. Rhino. Laryn., May 1985. 164. Takeda, T., Stuart, J.M., Floyd, R.A., and Yoo, T.J.: Auditory Brain Stem Response (ABR) in Rodents with Type II Collagen-Induced Autoimmune Ear Diseases. World Cong. Oto. Rhino. Laryn., May, 1985. 165. Yoo, T.J., Sudo, N., Yazawa, Y., Floyd, R.A., Ishibe, T., and Takeda, T.: A Guinea Pig Model of Autoimmune Endolymphatic Hydrops. New York Academy of Sciences Meeting, New York, New York, June 1985. 166. Yoo, T.J., Stuart, J.M., Takeda, T., Sudo, N., Floyd, R., Ishibe, T., Olson, G., Orchik, D., Shea, J.J., and Kang, A.H.: Induction of Type II Collagen Autoimmune Arthritis and Ear Disease in Monkey. New York Academy of Sciences Meeting, New York, New York, June 1985. 167. Floyd, R.A., Hue, S.H., Kim, H.Y., and Yoo, T.J.: Modified Alternaria Allergen Immunotherapy in Mice. Int'l. AACI Meeting, Washington, D.C., October 1985. 168. Sudo, N., Yoo, T.J., and Floyd, R.A.: Type II Collagen-Induced Autoimmune Endolymphati. 169. Yoo, T.J.: Type II Collagen Mediated Autoimmune Middle Ear Disease: Eustachian Tube Disease, Otitis Media with Effusion and Tympanosclerosis. Int'l. Symposium on Otitis Media with Effusion, Kyota, Japan, January 1985. 170. Yoo, T.J., Sudo, N., Floyd, R., Ishibe, T. and Tomoda, K.: Type II CollagenInduced Autoimmune Salpingitis in the Rat. Int'l. Symposium on Otitis Media with Effusion, Kyota, Japan, January 1985. 171. Yazawa, Y., Yoo, T.J., Ishibe, T., and Tomoda, K.: Type II CollagenInducedTympanosclerosis Model in Guinea Pigs. Int'l. Symposium on Otitis Media with Effusion, Kyota, Japan, January 1985. 74 172. Yoo, T.J., Floyd, R.A., Sudo, N., Takeda, T., Ishibe, T., and Choe, I.S.: Factors Influencing Collagen-Induced Autoimmune Ear Disease (CIAED). Int'l. Conf. Current Aspects of Basic Clin. Ear. Res., Oita, Japan. Lectures : 173. “Hands On" Practical Skills Workshop. Fifth Annual: Hands on" Practical Skills Workshop. University of Tennessee. Nashville, July 29 - July 31, 1985. 174. Collagen Autoimmunity and Hearing Loss. Southeastern Immunology Conference (SEIC), Stone Mountain, GA. October 10 October 11, 1985. 175. Induction of Type II Collagen Autoimmune Arthritis and Ear Disease In Monkeys. XII International Congress of Allergy and Clinical Immunology (IXAXI) Oct. 20 - Oct. 25, 1985. 176. Autoimmunity of cochlea, Invited Speaker, Johns Hopkins University, Baltimore, MD, October 1985. 177. Autoimmunity of Cochlea, Invited Speaker, American Assoc. Otolaryngol. Allergy Annual Meeting, October 1985, Atlanta, GA. 178. Autoimmunity of Cochlea, Invited Speaker, Shiga University, Otsu, Japan, February 1986. 179. Autoimmunity of Cochlea, Invited Speaker, Kyoto University, Kyoto, Japan, February 1986. 180. Autoimmunity of cochlea, Invited Speaker, Osaka ENT Association, Osaka, Japan, February 1986. 181. Autoimmunity of cochlea, Visiting Professor, Kausai University Medical School, Dept. of Nephrology and Dept. of Otolaryngology, Osaka, Japan, February 1986. 182. Autoimmunity of cochlea, Visiting Professor, Yonsei University Medical School, Seoul, Korea, February 1986. 183. AIDS update, Visiting Professor, Seoul University Medical School, Seoul, Korea, February 1986. 184. AIDS update, Visiting Professor, Han Lim University Medical School, Seoul, Korea, February 1986. 185. Nineteenth Annual Review Course for the Family Physician. March 16-21, 1986. 186. New Approaches to sensorineural hearing loss. Columbia University, New York, NY, 187. AIDS update, Invited Lecturer, National Medical Center Seoul, Korea, May 1986. 188. AIDS update and autoimmunity of cochlea, Invited Lecturer, Kyung Hee University Medical School, Seoul, Korea, May 1986. 189. AIDS update, Invited Lecturer, Ewha Women's University Medical School, Seoul, Korea, May 1986. 190. AIDS update, Invited Lecturer, Han Yang University, Seoul, Korea, May 1986. 191. AIDS update, Invited Lecturer, Catholic Medical School, Seoul, Korea, May 1986. 192. AIDS update, Invited Lecturer, In-Je University Medical School, Pusan, Korea, May 1986. 193. AIDS update, Invited Lecturer, Asian Congress of Allergy and Immunology, Kwang-Ju, Korea, May 1986. 75 194. Pathogenesis of endolymphatic hydrops, Visiting Professorship, University of Utrecht, 2nd International Conference of Immunol. Of the Ear, Utrecht, Netherlands, August 1986. 195. Autoimmunity of cochlea, Visiting Professorship, University of Rio de Janeiro, Brazil, October 1986. 196. Allergy treatment update, Visiting Professorship, University of Sao Paulo, Brazil, 28th Brazilian Congress of Otolaryngology, October 1986. 197. Transfer Factor Treatment in Hepatitis, Invited Lecturer, Korean Genetic Engineering Institute, Seoul, Korea, April 1988. 198. Transfer Factor Treatment in Hepatitis, Invited Lecturer, Catholic Medical School, Seoul, Korea, April 1988. 199. Immunointervention in Autoimmune Disease, Invited Lecturer, Paris, France, June 1988. 200. International Symposium on Meniere's Disease, Cambridge, Mass., June 1988. 201. Autoimmune Ear Disease, University of Barcelona, Visiting Professor, Barcelona, Spain, February 1989. 202. Autoimmune Ear Disease, University of Tubingen, Visiting Professor, Tubingen, Germany, March 1989. 203. Treatment update in allergic disease, 34th U.S. Army General Hospital, Augsborg, Germany, March 1989. 204. Autoimmunity of Inner ear: panel speaker, International Conference of Otolaryngology of Head & Neck Surgery, Madrid, Spain, September 1989. 205. Otoslcerosis: panel speaker, International Conference of Otolaryngology of Head & Neck Surgery, Madrid, Spain, September 1989. 206. Autoimmune Inner Ear Injury: Mechanism and Treatment, Conjoint seminar, ENT. Department, Koshin University Medical School & Pusan National University Medical School & Pusan ENT Association, Pusan, Korea, December 1989. 207. V-region cDNA Sequences of type II collagen antibodies which induce relapsing polychondritis in mice, 27th Workshop on Inner Ear Biology, Stockholm, Sweden, June, 1990. 208. Collagen autoimmunity and ear diseases, 3rd International Academic Conference of Immunobiology in ENT, Coronado, CA, November 1990. 209. Epitope Specificity of Type II Collagen in Autoimmune Disease, Dong A. Univ. Medical School, Pusan, Korea, April 1991. 210. Molelcular Biology of T-Cell Receptor, Department of Medicine, Han Yang Univ., Seoul, Korea, April 1991. 211. T-Cell Receptor Repertoire in Autoimmune Disease, Department of Medicine, Kyung Hee University, Seoul, Korea, April 1991. 212. T-Cell Receptor Repertoire in Autoimmune Disease, Loma Linda Medical School, Loma Linda, CA., October 1991. 213. Molecular Basis of Autoimmune Ear Disease, Grand Rounds, Department of ENT, Univ. of California, Irvine Medical Center, Irvine, California, October, 1991. 214. Current concept of Autoimmune Disease, Grand Rounds, Department of Internal Medicine, Seoul University Medical School, Seoul, Korea, November 1991. 76 215. Curent Concept of Autoimmune Disease, Department of Medicine, Catholic University Medical School, Seoul, Korea, November 1991. 216. Molecular Biology of Autoimmune Ear Disease, Korean Otologic Study Group Symposium, Seoul, Korea, November 1991. 217. 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What is allergy and allergic disease: Allergy update, Diagnosis & Treatment, SBS Television, Seoul, Korea, November 1994. 242. All you have to know about allergy, KBS Television, Seoul, Korea, November 1994. 243. Human Genome Project & 21st Century Medicine, FASEB/Korean Biology Meeting, keynote speaker, Atlanta, GA, April, 1995. 244. Autoimmunity of the Cochlea, 2nd annual meeting of the ELAS, Brussels, Belgium, April 1995. 245. 30KD gene product & Meniere's disease, Clin. Univ. St. Luc, Brussels, Belgium, April 1995. 246. Oral tolerance of autoimmunity 7 allergy, BMR, Bethesda, MD., September 1995. 247. Molecular Biology of hearing & deafness, Bethesda, MD, October 1995. 248. Human genome project and 21st century medicine, Han Yang University, Seoul, Korea, October 1995. 249. Korea Allergy Society "Search for a new immunotherapy for housedust mite (HDM) allergy; cytokine expression in mice tolerated to HDM using cholera toxin B (CTB) and restrictive usage of TCR Va and Vb genes in HDM Sensitive mice, November 1995. 250. Roswell Park Cancer Institute, "Autoimmunity of the Cochlea, Buffalo, NY, December 1995. 251. Human genome project and 21st century medicine, Sam Sung Adramed Institute of Technology, Ki Heung, Seoul, Korea, April 1996. 252. Human genome project and 21st century medicine, San Sung Bioscience Institute, Seoul, Korea, April 1996. 253. Human genome project and 21st century medicine, Ajou University Medical School, Suwon, Korea, April 1996. 254. Molecular basis of type II collagen autoimmune disease, 5th Asia Pacific Congresson Deafness, Seoul, Korea, 1996. 255. Antibodies against inner ear protein in the sera of patients IED, 5th Asia Pacific Congress on Deafness, Seoul, Korea, 1996. 256. Prevention of hearing loss in EAE mice using antibody therapy, 5th Asia Pacific Congress on Deafness, Seoul, Korea, 1996. 257. Auditory brainstem response (ABR) studies of EAE mice, 5th Asia pacific Congress on Deafness, Seoul, Korea, 1996. 258. Cloning of inner ear antigens in Meniere's disease, 5th Asia Pacific Congress on Deafness, Seoul, Korea, 1996. 259. Amherst Otolaryngology Center, Positano, Italy on "Type II & Type IX Collagen as Epitopes for Auto-antibody and autoimmune Sensorineural hearing Loss, 1996. 260. BioMedical Research Center, KAISR, Taejon, Korea on "Trends in BioMedical Research",1996. 78 261. University of Wisconsin medical school, New York, NY on "New directions in the Management of Asthma & Allergy, 1996. 262. University catholique de Louvain, Brusells, Lectures & Seminars to the Department of Biological Science, 1996. 263. Autoimmune hearing loss in mice induced by myelin Po protein. FASEB, Saxton Rivers, Vermont, 1997. 264. Restricted T-cell receptor alpha gene segment (TCRAP usage in house dust mite induced sensitivity). ARO Midwinter Meeting- St. Petersburg, FL, 1997. 265. Immunologic variables in a murine model of house dust mite sensitivity. AAAA& I/AAI /CIS Joint Meeting , San Francisco, CA, 1997. 266. Restricted VB t-cell receptor usage in Murine collagen induced autoimmune ear disease. AAAA& I-AAI /CIS Joint Meeting , San Francisco, CA, 1997. 267. Restricted TCRBV 852 usage in the cochlear ear lesion of EAE mice. 268. AAAA&I/AAI/CIS Joint Meeting, San Francisco, CA, 1997. 269. Oral tolerance in the collagen induced chondritis. AAAA& I/ AAI/ CIS Joint Meeting, San Francisco, CA, 1997. 270. Type II collagen epitopes for autoimmune ear disease. XVI World Congress of Otorhinolaryngology, Sydney, Australia, 1997. 271. The cochlear protein antigens in Meniere's disease. XVI World Congress of Otorhinolaryngology, Sydney, Australia, 1997. 272. Raf-1 protein as a potential antigen in autoimmune inner ear disease. 34th Workshop on Inner Ear Biology, Bari, Italy, 1997. 273. Autoimmune hearing loss in mice induced by myelin Po protein. 34th Workshop on Inner Ear Biology, Bari, Italy, 1997. 274. Restrictive TCRBV 852 usage in the cochlear ear lesion of EAE mice. 34th Workshop on Inner Ear Biology, Bari. Italy, 1997. 275. Molecular basis of type II collagen autoimmune disease: observation of arthritism auricular chondritis and tympanitis in mice. 34th Workshop on Inner Ear Biology, Bari, Italy, 1997. 276. Oral tolerance in the collagen induced chondritis. 34th Workshop on Inner Ear Biology, Bari, Italy, 1997. 277. Comparision of aeroallergen skin test reactions between Korean and Memphis allergy patients. ACAAI, San Diego, CA, 1997. 278. A single high dose injection of an immunodominant peptide of Der PI causes tolerance in house dust mute sensitized mice. ACAAI, San Diego, CA 1997. 279. A case of urticarial vasculitis with probable autoantibody to high affinity IGE receptor or IGE. ACAAI, San Diego, CA, 1997. 280. Role of autoantigens in patients with inner ear disease. ACAAI, San Diego, CA, 1997. 281. IGE and T cell responses in a murine model of house dust mite sensitivity. ACAAI, San Diego, CA, 1997. 282. Appearance of hearing loss in PO protein immunized mice. ACAAI, San Diego, CA, 1997. 283. A study of allergic parameters in atopic patients of a negative reaction to histamine despite positive reactions to antigens. ACAAI, San Diego, CA. 1997. 79 284. Experimental model of house dust mite (HDM) allergy in mice. ACAAI, San Diego, CA, 1997. 285. T-cell receptor expression in autoimmune ear disease. ACAAI, San Diego, CA, 1997. 286. Oral tolerance to HDM in mice using cholera toxin Bsubunit (CTB). ACAAI, San Diego, CA, 1997. 287. Interstitial cystitis as a differential diagnosis of idiopathic flushing. ACAAI, San Diego, CA, 1998. 288. Gene Therapy of house dust mite allergy by DNA vaccination. ACAAI, San Diego, CA, 1998. 289. Inner ear disease induced by directly infusing type II collagen into inner ear of guinea pig. ARO Midwinter Meeting, St. Petersburg, FL 1998. 290. Production of endolymphatic hydrops induced by directly infusing monoclonal antibody against type II collagen CBII peptide. ARO Midwinter Meeting, St. Petersburg, FL. 1998. 291. Oncogen Raf-1 as an autoantigen Meniere's disease. ARO Midwinter Meeting, St. Petersburg, FL. 1998. 292. Role of autoantigens in patients with Menieres's disease and other inner ear diseases. ARO Midwinter Meeting, St. Petersburg, Fl. 1998. 293. Immunologyof middle ear disease. Second A Charles Holland Course: Basic Sciences in Audiology and Otoneurology, Ferrara, Italy, 1998. 294. Immunology of retrocochlear hearing loss and new horizons on gene therapy and vaccination in ORL. Second A Charles Holland Course: Basic Sciences in Audiology and Otoneurology, Ferrara, Italy, 1998. 295. Immune systems mucosal immunity, antigen recognition, T cell receptors, costimulations, tolerance. Second A Charles Holland Course: Basic Sciences in Audiology and Otoneurology, Ferrara, Italy, 1998. 296. Hearing loss and autoimmunity: AAAA& I 55th Annual Meeting, Orlando, FL 1999. 297. Role of IgE and Otitis Media. AAAA & I 55th Annual Meeting, Orlando, FL 1999. 298. Autoantibodies in the sera of autoimmune inner ear disease. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 299. Immunohistochemical localization of ß-tubulin in guinea pig inner ear and labeling changes after tubulin immunization. ARO, St. Petersburg, FL 1999. 300. Immunoprotective effect of vaccination with DNA encoding T cell epitopes on the Der p induced IgE production. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 301. The effect of the intradermal vaccination with DNA encoding the T cell receptor on the induction of experimental autoimmune encephalomyelitis in mice. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 302. Inner ear disease induced by directly infusing type II collagen into inner ear of guinea pig. AAAA& I 55th Annual Meeting, Orlando FL 1999. 303. Raf-1 protein as a potential antigen in Meniere's disease. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 80 304. The ß-tubulin as an autoantigen for Meniere's disease. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 305. Autoantibodies to tubulin and collagen type II, IX, XI, in the sera of patients with systemic lupus erythematosus. AAAA& I 55th Annual Meeting, Orlando, FL 1999. 306. Autoantibody to the proto-oncogene c-raf in the sera of patients with systemic lupus erythematosus. AAAA& I 55th Annual Meetiing, Orlando, FL 1999. 307. The beta tubulin as an autoantigen for autoimmune inner ear disease. ARO Midwinter Meeting. St. Petersburg, FL 1999. 308. Production of endolymphatic hydrops induced by directly infusion monoclonal antibody against type II collagaen CB11 peptide. 4th International Symposium on Meniere's Diseases. Paris, France, 1999. 309. Autoantibodies in the sera of Meniere's disease. 4th International Symposium on Meniere's Diseases. Paris, France, 1999. 310. Raf-1 protein as a potential antigen in Meniere's disease. 4th International Symposium on Meniere's Diseases. Paris, France, 1999. 311. The ß-tubulin as an autoantigen for Meniere's disease 4th International Symposium on Meniere's Diseases. Paris, France, 1999. 312. Presence of autoantibodies in the sera of Meniere's disease. American Otological Society, Inc.132nd Annual Meeting, Palm Desert, CA. 1999. 311. Gene therapy of allergy and bronchial asthma. KAIST (BMRC) Korea, 1999. 312. Gene therapy of the 21st Century. SNUCMAA -The 16th Annual Summer Medical Convention, Chicago, IL 1999. 313. Biotechnology of USA 1999. International Molecular Biology Network Meeting 1999. October Seoul, Korea. 314. Gene therapy of Allergy and Asthma. University of Genoa, Italy, November 1999. 315. Autoimmunity of Hearing Loss, Seminar. AAAA & I Annual Meeting in San Diego. 316. Gene Vaccination of Allergy. International Symposium of Nasal Polyps. Siena, Italy, October 2000. 317. Autoimmunity of Cochlea and Gene Vaccination of Allergy. Kanazawa University, Japan. March 2001. 318. Autoimmunity of Cochlea. Shiga University, Japan. March 2001. 319. Autoimmunity of Cochlea. Kochi University, Japan. March 2001. 320. Autoimmunity of Cochlea. Catholic University Medical Center, Seoul, Korea. March 2001. 321. Molecular Basis of Autoimmune Hearing Loss, Seville, Spain 2002. 322. Autoimmune Hearing Loss, Catholic University, Brussels, Belguim 2002. 323. International Symposium of Autoimmunity of Cochlear, Genoa, Italy 2002. 324., The Recombinant Tissue Plasminogen Activator (RTPA) Up Regulates IL-8 and Matrix Metallo Proteinase 1, ACAAI, 2003. 325. , The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, AAAAI, 2003. 1 326. Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, AAAAI, 2004. 81 327 , Inner Ear Injury in Apolipoprotein E-deficient (Apo-E-ko) mice, ARO, 2004. 328. Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, ARO, 2004. 329.CA2, T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, ARO, 2004. 330. A Mouse Mutagenesis Screen to Identify Genes Important for hearing, ARO, 2004. 331. , The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, ARO, 2004. 332 The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalalloproteinase 1 Activities, FASEB, 2004. 333. T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, FASEB, 2004. 334. Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, FASEB, 2004. 335., Inner Ear Injury in Apolipoprotein E-deficient (Apo-E-ko) mice, FASEB, 2004. 336 Allergy Immune Response is Modulated by DNA Vaccination For Cockroach Allergy In Mice, FASEB, 2004. 337. T-cell Mediated Gene Therapy For Collagen Induced Ear disease CIED In Mice, FOCIS, 2004. 338. The Recombinant Tissue Plasminogen Activator (rTPA) Enhances Il-8 And Matrix Metalloproteinase 1 Activities, FOCIS, 2004. 339. Naked DNA Encoding INF-gama Enhances Tubulin Induced Hearing Loss in Guinea Pigs, FOCIS, 2004. 340. Naked DNA Encoding INF-g Enhances Tubulin Induced Hearing Loss in Guinea Pigs IFOS 2005; International federation of Otolaryngological society. 2005, Rome Italy 341. Characterization of immune response in β-tubulin induced murine autoimmune hearing los 5th Annual International Symposium Meniere's Disease & Inner Ear Homeostasis Disorders. April 2005, Los Angels, CA 342. Immune responses in tubulin induced hearing loss in miceI IFOS 2005; International federation of otolaryngological society. June 2005, Rome Italy 343.Immune response in tubulin induced hearing loss in miceII IFOS 2005; International federation of otolaryngological society. June 2005, Rome Italy 344.Immune respo nses of tubulin mediated hearing loss in mice. I.E.B. (inner ear Biology Meeting) Sept. 2005, Tubingen, Germany 82 345. Immunology of Ear, Kyung Hee Univeristy, ENT Dept. Seoul 2005 April 345 Ilchun Awrd lecture Korean Society of cellular and molecular Biology, Oct 2005, Seoul, Korea 346.Murine experimental autoimmune hearing loss mediated by CD4+ T cells and antibodies specific for β-tubulin. San Diego,Ca 347 β-tubulin-induced autoimmune hearing loss exacerbates in IL-10-deficient mice and restores by IL-10 gene transfer, Focis meeting, San Diego 348 ß-tubulin induced Murine Model of Autoimmune Hearing Loss and Regulation of Tcell Cytokaines of the Mice, American Academy of Allergy, Asthma & Immunology (Annual Meeting, Jan 2007, 349 ß-tubulin induces auto-immune inner ear disease, ARO association for research in Otolaryngology mid winter meeting February 11-15/2007. 350 Adoptive Immunotherapy of Experimental Autoimmune Hearing Loss Via T Cell Delivery of the IL-12 p40 Subunit, Aro 2007 351 inflammation in the murine model of house dust mite allergy, Rome, Italy, Allergome meeting 352 β-tubulin Induced Murine Model of Autoimmune Hearing Loss and Regulation of T Cell Cytokines of the Mice, AAAAI meeting 353DNA Vaccine, 2007 Spain DAN vaccination of cockroach allergy Blag 1.Malaga, Spain 354 Restoratuion of hearing by adoptive cellular gene therapy, International otology conference, Venice, Italy 355 Restoration of hearing by DNA vaccine < Seoul national University medical college alumni scientific conference, atlantic city 2006 356 Geneticc of hearing loss, Univeristy of Ferrara, Ferrara, Italy, 2007 357 Gene vaccine for allergy and asthma, Roundtable discussion, International congress of rhinology, 2007, Venice, Italy. 358 DNA vaccines for Alzheimer’s disease, Las Vegas,Seoul University Alumni meeting asienctif session, Las Vegas, March 2008. 83 359 Dna vaccine for chronic neurologic disease, Research Saminar, Xdept cell and Molecular biology, College of medicine, Kyung book University, Tae Gu Korea June 2008. 360 Autoimmune hearin gloss, Seoul National University ENT dept seminar,2008 361 Dna vaccine for alzheimer’s disease, Univ Tennessee, Collerge of Medicine, Endocrinology Division conference, 2008 362 DNA vaccine for Alzheimer’s disease, Keunkuk University, Biomeical center, 2008 363 DNA vaccine for Alzheimer’s disease, Crystal Genomics, research conference,2008 364 DNA vaccine for Alzhheimer’s disease, 11th Internatrional Molecular Biology Net work meeting, Seouol, Korea, October,2008 365 Gene therapy and stem cell therapy of 21st century, Catholic Univsity medical center,2009 June, Seoul, Korea 366 Gene therapy and stem cell therapy of 21 st century, Ham Yang University, Seoul, Korea 367 Stem cell therapy Rheumatology research seminar, UT Memphis, septem ber 2009 368 Gene therapy and stem cell therapy of 21st century,Dept of Molecular Biuology, Seoul National Univcersity. Seoul ,Korea 369 Update 0n Alzheimer’s disease vaccine, SNU College of Medicne Alumni meeting research conference, July , 2009, Dearborn,Michgan 370. Adipose tissue derived stem cell therapy. SNU college of Medicine Alumni meeting , 2009,july 371. A New Insight of Stem Cell Therapy, Pulmonary Div Research Conference,UT, sept,2009 372. Stem cell therapy update , Ulsan Medical school , Dept of Neurology seminar.July 2009. 373. Stem Cell therapy, Hanyang University 2010 374 Stem cell thertapy. Ewha University 2011 375 Stem cell Therapy. Daegu catholic university,2011 376Stem cello therapy. Jilin University.Jilin ,China,2012 84 377 Stem Cell therapy. Padova Univeristy,Padova,Italy 2012 378 Syposium chair, moderator, and speaker in IFOS seoul,2013 on autoimmune hearin gloss: pathogenesis, immunodiagnosis and therapies..gene therapy and stem cell therapy,June 15,Seoul,Korea; Stem cell theraqpy and gen etherapy restore hearing in experimental animal and human. 379 Blag1 DNA vaccine for cockroach allergy, IFOSSeroul,2013 380 Stem cell aqnd genm etherapy restore hearing in humamn and experimental hearing loss IFOSSeoul,2013 381 Gene therapy with IL10 resore hearing in IL-10m deficient mice.IFOSSeoul,2013 (4) Reviews: Current concept of Meniere's disease, Deafness Research Foundation Letter. New York, N.Y., January 1983. End of CV 85