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Additional file 7 – Additional table S7 – Gene description (according to SAPD
database [28]), GO classification and FC of down-regulated genes in VSa16 cells
with FC higher than 10 in control versus mineralization. GO classification was
subdivided in biological processes (BP), molecular function (MF) and cellular
component (CC). Raw data was normalized using quantile method and then a two class
SAM test was performed; FDR was limited to 5%.
Gene description
Alcohol dehydrogenase Class VI
[Q6B4J3]
No match
Angiopoietin-related protein 7 [O43827]
Plasma retinol-binding protein (PRBP)
[P02753]
Similar to normal mucosa of
esophagus-specific gene 1
No match
Fibulin 5
Kainate receptor beta subunit. [Q90278]
Betaine-homocysteine methyltransferase
(BHMT) [Q5PSM1]
No match
Similar to unnamed protein
No match
No match
No match
Actin, alpha skeletal muscle 1 [P68140]
Similar to unnamed protein
No match
No match
No match
No match
No match
Glucose-6-phosphate isomerase
[P06744]
No match
Similar to male-specific protein
Interferon induced protein 2 [Q8JH61]
No match
Troponin T [P13805]
Cytosolic sulfotransferase 3 [Q6DHG7]
Angiopoietin-related protein 4 [Q9BY76]
No match
Heat-shock protein ß-7 [Q9UBY9]
No match
EGF-like domain-containing protein 7
[Q9UHF1]
No match
No match
No match
No match
No match
No match
ERO1-like [NP_956644]
GO (BP/ MF/ CC)
FC
- / Zn ion binding, oxidoreductase activity / -
221.3
-/-/signal transduction / receptor binding / -
121.5
79.1
transport / transporter activity, retinoid binding / -
76.4
-/-/-
73.4
-/-/- / Ca ion binding / ion transport /extracellular-glutamate-gated ion channel / integral
to membrane, postsynaptic membrane, cell junction
67.7
66.4
betaine-homocysteine S-methyltransferase activity
58.2
-/-/-/-/-/-/-/-/-/-/- / structural molecule activity, ATP binding, protein binding /
cytoplasm, cytoskeleton
-/-/-/-/-/-/-/-/-/-/-/-/gluconeogenesis, glycolysis / glucose-6-phosphate isomerase
activity / -/-/-/-/response to biotic stimulus / - / integral to membrane
-/-/-/-/- / sulfotransferase activity / signal transduction / receptor binding / extracellular
-/-/-/-/-/-/-
53.8
34.5
32.0
29.4
29.2
-/-/-
13.6
-/-/-/-/-/-/-/-/-/-/-/-/protein folding / protein thiol-disulfide exchange, unfolded protein
13.5
13.5
13.1
13.0
12.2
12.2
11.9
66.1
28.1
23.6
22.9
21.7
21.7
21.2
20.4
20.4
20.2
17.2
16.0
15.9
15.0
15.0
14.4
14.0
13.9
13.7
No match
No match
Similar to tetratricopeptide repeat 36
Hepcidin-like. [Q6Q5X4]
No match
No match
SDR12 isoform 2 [NP_078981]
Matrix gla protein (MGP) [P08493]
No match
response, protein binding, oxidoreductase activity, FAD binding /
endoplasmic reticulum membrane
-/-/-/-/- / binding / -/-/-/-/-/-/metabolic process / oxidoreductase activity / - / Ca ion binding / extracellular region
-/-/-
11.9
11.4
11.3
10.9
10.8
10.5
10.3
10.3
10.2