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Department of Anatomy & Histology The Circulatory System The circulatory system comprises both the blood and lymphatic vascular systems. The blood vascular system is composed of the following structures: 1- The heart, an organ whose function is to pump the blood. 2- The arteries, a series of efferent vessels that become smaller as they branch, and whose function is to carry the blood, with nutrients and oxygen, to the tissues. 3- The capillaries, the smallest blood vessels, constituting a complex network of thin tubules that anastomose profusely and through whose walls the interchange between blood and tissues takes place. 4- The veins, which result from the convergence of the capillaries into a system of channels. These channels become larger as they approach the heart, toward which they convey the blood to be pumped again. The internal surface of all components of the blood and lymphatic systems is lined by a single layer of a squamous epithelium, called endothelium. Blood vessels are usually composed of the following layers, or tunics: 1- TUNICA INTIMA : consists of one layer of endothelial cells supported by a subendothelial layer of loose connective tissue containing smooth muscle cells. In arteries, is separated from the tunica by an internal elastic lamina. Tunica Intima a- Endothelium b- Subendothelial layer. c- Internal elastic lamina. 2- TUNICA MEDIA :Layers of smooth muscle cells with amounts of elastic fibers, reticular and collagen fibers. In arteries, the media has a thinner external elastic lamina, which separates it from the tunica adventitia. 3- TUNICA ADVENTITIA : consist of collagen and elastic fibers. The arteries are classified according to their increasing size into : 1- Arterioles and small arteries. 2- Medium (muscular) arteries. 3- Large (elastic) arteries. Venous blood are usually grouped into three classes: 1- Venules. 2- Small to medium – sizes venis. 3- Large venis. Tunica Intima a- Endothelium. b- Subendothelial. c- Internal elastic lamina Media External elastic lamina Adventitia Tunica Intima a- Endothelium. b- Subendothelial. c- Internal elastic lamina Media External elastic lamina Adventitia Arterioles and small arteries Medium arteries Present Very thin Absent 1-2 layers of smooth muscle cells. Absent Present Thick Present Up to 40 layers Very connective tissue Thin tissue Venules Present Very thin Absent Thin layer absent Thick Fiber blast, elastic, collagen fibers Large arteries Present Thick Present Elastic fiber forming 40-70 of elastic lamina with smooth muscle cells and reticular fibers present. connective Relatively under developed. Small to medium Large veins Present thin absent Small bundles of smooth muscle, reticular elastic, absent Collagenous tissue Present thin Present Much thinner, smooth muscle cells and connective tissue absent. Thickest Contains longitudinal bundles of smooth muscle. Capillaries : The smallest blood vessels in the body. They are composed of a single layer of endothelial cells surrounding by connective tissue. There are three types of capillaries in the body. 1- The continuous: Are characterized by the absence of fenestrace in their wall they are found in all types of muscle tissue, connective tissue exocrine glands and nervous tissue. 2- The fenestrated are characterized by the presence several openings in the endothelium membrane. This type found in the endocrine organs, small intestine and the glomeruli of kidney. 3. sinusoids are found in the liver, spleen and bone marrow. The sinusoids have a tortuous path and greatly enlarged diameter, though the organ. Vasa Vasorum : The walls of large vessels are too thick to receive nourishment by direct diffusion from the lumen. As a result, the walls of these vessels have their own small blood vessels called the vasa vasorum (vessels of the vessel). Reference : 1- Junquera, L. C. and Carnero, J. (2005). Basic histology. 11th ed.