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Text of Slides from Management of Tuberculosis in Emergency Department Settings Web-based Seminar Presented on November 19, 2009 Housekeeping Slides Dr. Lee Reichman Slide 1: Management of Tuberculosis in Emergency Department Settings o Sponsored by New Jersey Medical School Global TB Institute Slide 2: Objectives o Upon completion of this seminar, participants will be able to: Describe how suspected TB patients present in the emergency department in order to more rapidly recognize infectious patients and provide appropriate management Identify appropriate diagnostic and treatment methods for TB in emergency department settings in order to provide effective cure of TB disease Describe personal respiratory protection and administrative infection control procedures in emergency departments in order to prevent transmission of M. tuberculosis Apply programmatic strategies to develop collaborative relationships between TB control programs and hospital emergency departments to reduce missed opportunities for appropriate treatment of TB patients Slide 3: Faculty o Elissa Schechter-Perkins MD, MPH, DTMH Boston University School of Medicine o Juanette Reece, MHS Baltimore City Health Department Tuberculosis Control Program Slide 4: Agenda o Overview & Opening Remarks – Dr. Lee Reichman o Overview of TB in Emergency Departments -- Dr. Elissa SchechterPerkins o Infection Control in the ED: Triage, Airborne Isolation, and Personal Respiratory Controls for Patients & Providers -- Dr. Elissa SchechterPerkins o Case Study: Program and Emergency Department Collaboration in Baltimore City – Juanette Reece, MHS o Discussion o Concluding Remarks – Dr. Lee Reichman Slide 5: Tuberculosis: Emergency Department Diagnosis, Treatment, and Infection Control By Elissa Schechter-Perkins MD, MPH, DTMH Assistant Professor of Emergency Medicine Boston University School of Medicine Slide 6: Topics of Discussion • • • First topic: Suspicion of TB Initial management Infection control Slide 7: Who Might have Tuberculosis EVERYBODY Slide 8: Who Might have Tuberculosis Worldwide: o Leading infectious cause of death o Affects over 1/3 of the world’s population o 1,700,000 people die from it every year United States: o Increased from 1980s to 1993 o In 2008, 4.2 cases per 100,000 people o 12,898 cases in the USA in 2008 Massachusetts o In 2008, 4.11 cases per 100,000 people o 261 cases in Massachusetts in 2008 Slide 9: Who Might have Tuberculosis EVERYBODY Slide 10: Why the ED • • • We see it We miss it We spread it Slide 11: Why the ED Picture of the Emergency Department at Boston Medical Center. Slide 12: Why the ED We see it We miss it We spread it Slides 12: Why the ED: We see it Everybody Slide 13: Why the ED: We see it Diagram with three circles. On the left are two circles: one representing the population at high risk for TB, and the other at low risk for TB. On the right is a circle representing Emergency Department patients. This shows that the patients at high risk for TB are in large part the same patients seen in the Emergency Department Slide 14: Why the ED: We see it Table showing number of reported cases of TB in the USA with various risk factors. In racial/ethnic minorities, 29% were Hispanic/Latino, 26% were Asian/Pacific Islander, and 25% were Black/African American. 59% of reported TB cases in the USA were in foreign-born persons, and 15% of reported cases also reported HIV infection. Note that information about HIV infection is limited by incomplete HIV reporting Slide 15: Why the ED: We see it • Table showing number of reported cases of TB in Massachusetts with certain risk factors. 9% of TB cases reported in Massachusetts had substance abuse issues, 3% were homeless (case rate of 29.4 per 100,000 people), 2% were connected with correctional facilities (case rate of 20 per 100,000 people), and 2% of TB cases were in nursing homes Slide 16: Why the ED: We see it • • • Most likely to have tuberculosis: ethnic minorities, foreign born, those with HIV, drug users, nursing home patients, homeless patients, prisoners Most Likely to have • No “usual source of care” • Acute illnesses requiring urgent medical attention Most Likely to show up to an ED near you Slide 17: Why the ED: We see it Diagram showing that people from the following groups are at higher risk of TB: o Ethnic minorities o Foreign born o HIV o Drug users o Nursing home o Homeless o Prisoners Slide 18: Why the ED: We miss it Slide 19: Why the ED: We miss it • In a 30 month time period, 44 contagious TB patients made 66 visits to the ED prior to diagnosis Slide 20: Why the ED: We miss it • Nearly 50% of newly diagnosed TB cases had antecedent ED visit in previous 6 months • An average of 2.2 visits • As approached diagnosis, more likely to have an ED visit • Those seen in the ED are the most sick of all TB patients Slide 21: Why the ED: We miss it • • In hospitalized patients, the median interval from admission to initiation of medications was 6 days 75% of patients had a delay of at least 24 hours Slide 22: Why Oh Why Picture of man at the beach with his swimwear sagging Slide 23: Why the ED: We miss it • Clinical presentation of TB can be variable and non-specific • Cough present in only 64% • Cough was chief complaint in only 20% • Only 36% had respiratory complaint at triage Slide 24: Why the ED: We miss it Clinical presentation of contagious TB patient may not even be related to TB Slide 25: Why the ED: We miss it • Definitive diagnosis is frequently not possible in the ED • Culturing the organism can take days to weeks • Ziehl-Neelson staining, which identifies Acid Fast Bacilli, is only 50-80% sensitive Slide 26: Why the ED: We spread it • Picture from the Rothman article illustrating that emergency departments are a high risk place propagation of infection and can serve as a potential bridge for aerosolized infection Slide 27: Why the ED: We spread it • • • Between patients From patients to health care workers From patients to family members Slide 28: Why the ED: We spread it between patients Emergency department infrastructure Slide 29 Picture of a large crowd of people Slide 30: Why the ED: We spread it between patients • Emergency department infrastructure • Overcrowding in the waiting room • Boarding in ED hallway or room without sufficient ventilation precautions Slide 31: Why the ED: We spread it from patients to staff • • Emergency department acuity • Intubation • Induced sputum Atypical presentations Slide 32: Why the ED: We spread it from patients to staff • Emergency department staff at risk • TST conversion from 1-12% • Higher than other hospital workers Slide 33: Why the ED: We spread it from patients to family • • Patients go upstairs Patients go home Slide 34: Topics of Discussion • • • Covered suspicion of TB Next topic: initial management Infection control Slide 35: Let’s Get Clinical Slide 36: Case #1 • • • • • CC: Cough, fever HPI: 35 y/o male with 4 days of cough productive of yellow sputum PMH: None Meds: None Exam: Febrile, well appearing, coughing. Rales at Right Lung Base Slide 37: Case #1 Chest x-ray showing possible pneumonia Slide 38: Community-Acquired Pneumonia • Patient NOT: • Ethnic minority • Foreign born • HIV • Drug user • Nursing home • Homeless • Prisoner • Organisms: S pneumoniae • H flu • Atypicals • Slide 39: Community-Acquired Pneumonia • High level drug resistant strep pneumoniae Slide 40: Community-Acquired Pneumonia Graphic of IDSA guidelines recommending use of a macrolide for communityacquired pneumonia Slide 41: Case #2 • Picture of nebulizer Slide 42: Community-Acquired Pneumonia Graphic of IDSA guidelines recommending that patients with co-morbidities or who were diagnosed with streptococcus pneumoniae in an area with a high rate of macrolide resistance should be prescribed a fluoroquinolone Slide 43: Community-Acquired Pneumonia • • Don’t we use respiratory fluoroquinolones to treat resistant TB?? Can this be a problem?? Slide 44: Community-Acquired Pneumonia: Fluoroquinolone Risk • Partially treated tuberculosis • Delay in diagnosis • Development of resistant tuberculosis Slide 45: Community-Acquired Pneumonia: Fluoroquinolone Risk • Appears to be more theoretical Slide 46: Community-Acquired Pneumonia: Fluoroquinolone Risk • • Of 428 Pts diagnosed with pulmonary tuberculosis: • 17% of patients had been prescribed a fluoroquinolone in previous 6 Months • Most within 90 days of diagnosis Only 3/74 who had been treated had resistant TB • All had received more than one course of fluoroquinolones Slide 47: Community-Acquired Pneumonia: Fluoroquinolone Risk • Among fluoroquinolone resistant tuberculosis, majority appear to be in MDR-TB • Likely secondary to multi-drug regimen • Not due to isolated fluoroquinolone use in the community Slide 48: Community-Acquired Pneumonia: Fluoroquinolone Risk • • Might be a bigger problem if • Prevalence of TB increases • Use of fluoroquinolones increases Consider trying alternative regimens Slide 49: Community-Acquired Pneumonia: Fluoroquinolone Risk • Consider missed TB if patient returns after failing course of fluoroquinolones Slide 50: Case #3 • 46 year old homeless male, born in Peru, complains of cough, fever, night sweats, and weakness for 1 month Slide 51: Clinical Suspicion • • We Learned: • Cough >2 weeks duration • Dyspnea • Fevers/chills • Night sweats • Weight loss • Hemoptysis We See: • Variable clinical presentation Slide 52: High Suspicion of TB • Decision to initiate treatment • Epidemiologic information • Clinical, pathologic, and radiologic findings • Microscopic findings of acid fast bacilli • Cultures for mycobacteria Slide 53: High Suspicion of TB in the Emergency Department • Chest X-Ray • Looking primarily for active tuberculosis Slide 54: Chest X-Ray Chest x-ray of a patient seen in Peru with active pulmonary TB. This is a fairly classic x-ray. Has a right upper lobe cavitary infiltrate Slide 55: Chest X-Ray X-ray showing milliary TB, with small 1-3 millimeter nodules throughout the lung field Slide 56: High Suspicion of TB in the Emergency Department • Sputum sample • Looking for AFB on smear (Ziehl-Neelson stain) • Rapid • Sensitivity of 60% in culture positive patients • Depends on skill of lab technician • Depends on bacillary load Slide 57: High Suspicion of TB in the Emergency Department • Sputum sample • Looking for AFB on smear (Ziehl-Neelson stain) • Rapid • Sensitivity of 60% in culture positive patients • Depends on skill of lab technician • Depends on disease level • Culture • Slower results • Gold standard Slide 58: High Suspicion of TB in the Emergency Department • Other Methods • PPD • QuantiFERON® Gold Slide 59: High Suspicion of TB in the Emergency Department • Disposition? • Can be treated as outpatient • NOT SO EASY!! • Not ill appearing • Appropriate social situation • Contact with local health department • MOST WILL BE ADMITTED Slide 60: Case #4 • 46 year old female, noncompliant with HIV meds, complains of cough for 1 month Slide 61: Case #4 Chest x-ray. A non-typical presentation of TB, but this is what the patient has. Slide 62: Tuberculosis AND HIV • • Occurs at ANY CD4 count (only 11.4%of TB patients have HIV) Degree of immunosuppression influences clinical, radiographic, and histopathologic presentation of TB • CD4>350: Appears as typical TB (RUL, +/- cavitations) • CD4<200: Extrapulmonary manifestations, sepsis syndrome with (-) CXR, no granulomas or cavitations, miliary TB Slide 63: Tuberculosis AND HIV • • • • 1/3 of co-infected AIDS patients have primary TB 2/3 have reactivation TB • 7-10% annual risk in HIV-infected patients with positive TST • In HIV uninfected, 5-10% lifetime risk Faster progression of HIV More severe TB in HIV Slide 64: Tuberculosis and HIV • • Sputum smear AND culture Need 3 (decreased sensitivity when immunocompromised) Slide 65: Case #5 • • • • • CC: Back pain HPI: 19 y/o male from Vietnam with gradually worsening back pain PMH: None Meds: None Exam: uncomfortable, significant tenderness over back Slide 66: Potts Disease CAT scan showing a problem with patient's vertebral body. Potts disease showing destruction of the vertebral body due to tuberculosis Slide 67: Potts Disease A picture of Potts Disease showing destruction of the vertebral body due to Tuberculosis in another patient. Slide 68: More Tuberculosis • • Can be anywhere Do NOT require isolation unless it is pulmonary or laryngeal Slide 69: Tuberculous Pericarditis X-ray showing tuberculosis pericarditis Slide 70: Tuberculosis Iritis Picture showing tuberculosis iritis Slide 71: Topics of Discussion • • • Covered: suspicion of TB Covered: initial management Next: infection control Slide 72: Why Bother? IT WORKS!!! Slide 73: Why Bother 6 fold decrease in development of LTBI after beginning TB infection control program Slide 74: Back to Basics • • • • Spread by droplet nuclei (airborne particles) From patients with pulmonary or laryngeal TB • Cough, sneeze, shout 1-5 µm Normal air currents keep particles airborne for prolonged periods Slide 75: High Risk Transmission • Exposure to TB in small, enclosed spaces • Inadequate local or general ventilation that results in insufficient dilution or removal of infectious droplet nuclei • Recirculation of air containing infectious droplet nuclei • Inadequate cleaning and disinfection of medical equipment • Improper procedures for handling specimens Slide 76: Sound Familiar? Picture of Emergency Department at Boston Medical Center Slide 77: Hierarchy of Infection Control Picture depicting the hierarchy of infection control. The picture has three bars in the shape of an inverse pyramid. At the top of the pyramid with the largest bar is administrative controls. In the middle of the pyramid, with a medium bar, is environmental controls. At the bottom of the pyramid, with the smallest bar, is respiratory protection Slide 78: Infection Control • • • Administrative controls: • reduce risk of exposure via effective IC program Environmental controls: • prevent spread and reduce concentration of droplet nuclei Respiratory protection controls: • further reduce risk of exposure in special areas and circumstances Slide 79: Administrative Controls • • • • Test and evaluate HCWs at risk for TB or for exposure to M. tuberculosis Train HCWs about TB infection control Ensure proper cleaning of equipment Use appropriate signage advising cough etiquette and respiratory hygiene Slide 80: Awareness Picture of a poster with a chest x-ray on the right with THINK TB superimposed over it. On the left is checklist that begins "Does your patient have...." any of the following risk factors: cough, fever, weight loss; positive TB test; history of TB; high risk factors, including international travel, HIV, homelessness, or healthcare worker. At the bottom is the contact information for the Massachusetts TB Division. Slide 81: Awareness Picture of a magnet with a clipboard on it. The top says Think TB, and the clipboard says cough of greater than 3 weeks, time in a high TB prevalence area, history of TB, and positive TB test. At the bottom of the magnet is contact information for the Massachusetts TB Division. Slide 82: Respiratory Protection (RP) Controls • • Implement RP program • Protocols • Training • Mask fitting Minimum respiratory protection is a filtering facepiece respirator • Nonpowered, air-purifying, half-facepiece • N-95 disposable Slide 83: Environmental Controls • Control source of infection • Dilute and remove contaminated air • Prevent spread of infectious droplet nuclei • Reduce concentration of infectious droplet nuclei • Control airflow (clean air to less-clean air) Slide 84: Environmental Controls • High Air Flow (At Least 6 Air Changes/Hour) • Air Cleaning Methods • High Energy Particulate Air Filtration (HEPA) • Ultraviolet Germicidal Irradiation (UVGI) • Negative Pressure • Air Exhausted to the outside Slide 85: Environmental Controls • Airborne Infection Isolation (AII) rooms (“TB room”) Slide 86: Environmental Controls • • 1995 Most ED’s did not have adequate engineering measures • 19.6% of EDs • 1.7% of triage/waiting areas Have things changed since then?? Slide 87: Resource utilization • • • If the ED has isolation rooms The trick is getting the appropriate patients into these rooms In the magic hat are protocols for identifying, evaluating, and managing infectious TB patients Slide 88: Triage • • Important and vulnerable point of entry into the ED and the hospital Effective strategy here will minimize nosocomial infections throughout ED and entire hospital Slide 89: Triage • • Initial patient encounter Consider infection control measures on arrival • Masking • ED isolation room • Notification of staff members Slide 90: Difficulties • • Triage procedures have met with limited success • In sensitivity • In specificity Problem is that talking to the patient is just not sufficient Slide 91: Plan • • • Mask everybody with a cough • Droplet precautions sufficient for most bacteria/viruses • Large droplets • Don’t remain suspended in the air “TB Rooms” for those with epidemiologic high risk factors High-risk procedures done only in rooms with non-recirculated air Slide 92: Admission to Hospital • If ED does not have isolation room: • Rapid identification of possible cases and rapid admission to hospital bed Slide 93: Admission to Hospital • If ED does have isolation room: • Screen high-risk patients in ED to determine who needs an isolation bed Slide 94: Decision Instrument • • • • • • • History of tuberculosis Immigrant Homeless History of incarceration Recent weight loss Chest radiograph with apical infiltrate Chest radiograph with cavitary lesion Slide 95: Decision Instrument • • Sensitivity: 96.4% Specificity: 48.7% Slide 96: What Have We Learned Slide 97: What Have We Learned • Emergency Departments are Dangerous Places!! Slide 98: What Have We Learned • • • Suspicion of TB Initial management Infection control Slide 99: Apologies for any... Picture of presenter holding a sloth Slide 100: References CDC. Reported Tuberculosis in the United States, 2008. Atlanta, GA: U.S. Department of Health and Human Services, CDC, September 2009 http://www.cdc.gov/tb/statistics/reports/2008/pdf/2008report.pdf 2008 Annual Statistical Report, Division of Tuberculosis Prevention and Control, Bureau of Infectious Disease Prevention, Response and Services, MA Department of Public Health Rao VK, Iademarco EP, Fraser VJ, et al. Delays in the suspicion and treatment of tuberculosis among hospitalized patients Ann Intern Med. 1999;130:404-411. Sokolove, PE et al. “The Emergency Department Presentation of Patients with Active Pulmonary Tuberculosis.” Academic Emergency Medicine Volume 7 Issue 9, September 2000. Long, R et al. “The emergency department is a determinant point of contact of tuberculosis patients prior to diagnosis.” The International Journal of Tuberculosis and Lung Disease. 6(4):332–339. April 2002. Rothman, RE et al. “Communicable Respiratory Threats in the ED: Tuberculosis, Influenza, SARS, and Other Aerosolized Infections.” Emergency Medicine Clinics of North America. 24(4) 2006. Mandell, Lionel Et Al. “Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community‐Acquired Pneumonia in Adults” Clinical infectious Disease. 44(5). 2007. Long, Richard Et Al. “Empirical Treatment of Community Acquired Pneumonia and the Development of Fluoroquinolone-Resistant Tuberculosis.” Clinical infectious Disease. 48:1354-1360. 2009. Low, Donald E. “Fluoroquinolones for Treatment of Community Acquired Pneumonia And Tuberculosis: Putting the Risk of Resistance into Perspective.” Clinical infectious Disease. 48:1361-3. 2009. Huang TS, et al. “Trends in fluoroquinolone resistance of Mycobacterium tuberculosis complex in a Taiwanese medical centre: 1995–2003.” Journal of Antimicrobial Chemotherapy. 56:1058–62. 2005 De Cock, Kevin M Et Al. “Tuberculosis and HIV Infection in Sub-Saharan Africa.” Journal of the American Medical Association. 268(12). 1992. Behrman A, Et Al. “Tuberculosis exposure and control in an urban emergency department.” Annals Emergency Medicine. 3(3):370–5. 1998. Centers for Disease Control and Prevention. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005. MMWR 2005;54(No. RR-17) Moran, GJ et al. “Tuberculosis infection-control practices in United States emergency departments.” Annals of Emergency Medicine. 26(3) 283-289. 1995; Moran, Gregory G et al. “Decision Instrument for the Isolation of Pneumonia patients with Suspected Tuberculosis Admitted Through US Emergency Departments.” Annals of Emergency Medicine. 53(5) 2009. Slide 101: The End Slide 102: Think TB in EDs: Response to the TB Outbreak in Baltimore City Homeless Persons Juanette Reece, MHS Baltimore City Health Department -TB Control Program Slide 103: TB Outbreak in the Homeless Population In 2004, smear-positive pulmonary TB was diagnosed in a homeless man o While contagious, the homeless TB patient made numerous visits to homeless service providers and health care providers The initial homeless TB case had 12+ clinical encounters From ’04-’08 Baltimore City had 39 outbreak linked TB cases o Several cases visited local emergency departments (EDs) (TB was not considered in the diagnosis) Slide 104: TB Cases in Baltimore City Homeless, 1999-2008 Graph showing TB Cases in Baltimore City Homeless, 1999-2008. In 1999, there were 2 non-outbreak linked cases. In 2000, there were 3 non-outbreak linked cases. In 2001, there was 1 non-outbreak linked case. In 2002, there were 4 nonoutbreak linked cases. In 2003, there were 2 non-outbreak linked cases. In 2004, there were 3 non-outbreak linked cases and 9 outbreak-linked cases. In 2005, there were 2 non-outbreak linked cases and 10 outbreak-linked cases. In 2006, there was 1 non-outbreak linked case and 1 outbreak-linked case. In 2007, there was 1 non-outbreak linked case and 14 outbreak-linked cases. In 2008, there were zero non-outbreak linked cases and one outbreak-linked case. Slide 105: Program Activities in Response to TB Outbreak Enhanced case findings among homeless persons Contact tracing Education of health care providers o Education of homeless service providers and clients o Environmental controls Slide 106: Education of Health Care Providers: Action Steps Identification of facilities to target Notification of outbreak Development of a 30 min. presentation for TB in-service trainings Coordinate and conduct annual in-service TB training Slide 107: Identification of Facilities Activities focused on “high priority” locations o High priority locations were defined as locations/settings at which transmission may have occurred based on epidemiological trends and data Homeless persons were frequently admitted and seen in the EDs of local hospitals Program activities were targeted to emergency department and infection control staff of these high priority locations then expanded overtime to include additional facilities Slide 108: Notification of Outbreak Initial communication of outbreak to EDs and infection control nurses (ICNs) o Bulletins o Emailed alerts o Newsletters o Phone calls Follow-up communication of outbreak o “Think TB” reminders to infection control and ED staff Slide 109: TB Alert Picture of the TB Alert sent to facilities with the following text: o The average homeless patient sees a physician several times a year o Often times a homeless person may identify emergency department physicians as their primary source of care o Most people with active TB are diagnosed in hospitals and emergency departments o Most people with active TB have a cough for several months before a diagnosis is made o During the winter months homeless individuals sometimes stay in crowded shelters o Due to the factors listed above homeless individuals are at a higher risk of becoming infected with and spreading TB disease. o WHAT CAN YOU DO?: Remain alert for signs and symptoms of TB: Cough >2 weeks, Fever and/or sweats, weight loss, fatigue Consider sending sputum for AFB smear and culture on all individuals with these signs/symptoms Call the Baltimore City Eastern Chest Clinic for questions or to refer a patient: 410-396-9413 Slide 110: Example of Reminder Message Since November, 2006, the city has had 6 confirmed cases of TB among homeless men. These men used only 2 homeless shelters, and we have been able to link their TB by DNA genotyping. We'd like to remind health care providers to THINK TB, and ask that you post the attached handout in your Emergency Department and Community Health Clinics, to remind the staff if they have a patient who is homeless and is coughing to think TB and get a sputum in addition to the Chest XRay. One of the staff members at the Eastern Chest Clinic would like to make arrangements to talk to the staff in the ED and clinics to expand on this handout and answer any questions. Please let us know of someone we could contact to arrange this. Thank you for your attention to this and your help. Baltimore City Health Department Eastern Chest Clinic Phone: 410-396-9413 Fax: 410-396-9403 Slide 111: Coordinating with Health Care Providers Established a point of contact for each facility (usually ICN) We requested to conduct TB in-service trainings with ED staff either by email or phone contact TB in-service training was delivered at least on an annual basis Slide 112: TB In-service Trainings Objectives: o Increase knowledge of TB o Increase awareness of outbreak o Reduce delay in diagnosis o Ensure appropriate referrals to the TB Control Program Slide 113: Key messages “Think TB” – consider TB in any homeless person with a cough > 2 weeks, night sweats, fever, and weight loss Prompt respiratory isolation and the use of masks Prompt diagnostic evaluation including the collection of 1 or more sputum samples Slide 114: TB In-service Trainings (continued) Trainings were delivered by either our medical director, nurse practitioner, nurse case manager, community health educator, or a combination Trainings included a TB refresher, information on homelessness in Baltimore City, and updates on the outbreak o Review and update of homeless TB outbreak o Barriers to effective prevention in the homeless population o Latent TB infection & TB disease o o o o Pathogenesis & transmission TB/HIV co-infection Diagnosis & treatment Recommended protocol & prevention Slide 115: Picture of CDC Think TB Poster The middle of the poster says “Think TB!” Scattered around the poster are signs and symptoms of tuberculosis: coughing up blood, weakness, loss of appetite, chest pains, anorexia, exposure to tuberculosis, significant skin test, weight loss, chills, failure to thrive, positive skin test, malaise, fatigue, abnormal x-ray, night sweats, fever, hemoptysis, difficult breathing, cough, and shortness of breath. The bottom of the poster says “Recognize positive signs and symptoms of Tuberculosis. Early diagnosis and treatment reduces spread. Contact your Health Department or Physician for more information.” Slide 116: What We Learned There were gaps in TB case detection in EDs Homeless individuals with TB were usually in the hospital at the time of diagnosis Program activities resulted in increased communication between health department and health care providers ED staff were very receptive to training and recommendations Slide 117: Thank you! Baltimore City Health Department TB Control Program Eastern Chest Clinic 620 N. Caroline St. 410-396-9413 Slide 118: Questions and Discussion Slide 119: Medical Consultation New Jersey Medical School Global TB Institute Information Line: 1-800-482-3627 Slide 120: Thank you for your participation!