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Functional Food Ingredients: Probiotics Second generation probiotics DSM Food Specialties has developed second generation probiotics that are the result of extensive screening of a vast collection of micro-organisms with potential probiotic effects. LAFTI® probiotics have recently been selected using today’s scientific techniques that focus on probiotic properties that are now known to be important: stability survival proven health effects safety LAFTI®‘s unique benefits are the direct result of this Second-Generation screening Available Probiotic strains: Lactobacillus acidophilus LAFTI® L10 Bifidobacterium lactis LAFTI ® B94 Lactobacillus paracasei LAFTI ® L26 What are probiotics? A natural part of our body The literal meaning of ‘probiotics’ is ‘for life’. Probiotics are a generic term for naturally occurring ‘friendly’ bacteria that are beneficial for health, which differentiates them from the ‘bad’ bacteria such as the well known Escherichia coli and Salmonella, causing diarrhea and other intestinal problems. The most famous probiotic families are Lactobacillus and Bifidobacterium. Many different types of probiotic bacteria grow in the human digestive tract, and together with other ‘friendly’ bacteria create a complex ecosystem in our intestines called the intestinal microflora. Probiotics are thus a natural part of our body. What makes a bacteria a probiotic? Three checks Why do we need probiotics? Staying healthy What makes a bacteria a probiotic? Three checks 3. Survival of the bacteria The bacteria must be alive when reaching the human gut in order to provide the health 1. Safe for consumption The bacteria to be used as probiotic must be a 'friendly' bacteria that is safe. By law, only safe bacteria are accepted on the market. However, the law does not yet regulate the definition ‘probiotics’. Anyone can claim a bacteria to be a probiotic bacteria. benefits. It is important to note that probiotic supplements in which the number of live bacteria CFU is guaranteed until the end of shelf life provide more certainty that you get a sufficient dose of 'friendly' bacteria than a supplement that only guarantees the dose "at time of manufacturing". 2. Measurable beneficial effects on health There must be scientific evidence available demonstrating the beneficial effects of the probiotic strain on our health. Very important is that this scientific evidence must be for a specific strain. For example, there are many different Lactobacillus acidophilus strains, such as Lactobacillus acidophilus LAFTI® L10. This strain is a probiotic, since there is scientific evidence available demonstrating the health benefits for this specific strain. Lactobacillus acidophilus LAFTI® L10 [family] [species] [strain] What are probiotics? A natural part of our body Why do we need probiotics? Staying healthy Why do we need probiotics? The important balance of the many different Staying healthy types of ‘friendly’ bacteria is easily Probiotic bacteria play an important role in digesting food as well as maintaining health. They produce short chain fatty acids, which promote colonic nutrition, help the body in breaking down food, assist the absorption of essential vitamins, and protect against attack from ‘bad’ bacteria such as E. coli and Salmonella. disturbed, however. External factors such as (antibiotic) medication, travel, changes in diet and stress as well as internal influences including microbial interactions and intestinal secretions can have a negative effect. As a result, undesirable ‘bad’ bacteria may invade, bringing symptoms such as diarrhea, constipation, and other bowel problems. Supplementing the daily diet with probiotics keeps the important balance of ‘friendly’ bacteria in place and thereby helps maintain health. What are probiotics? A natural part of our body What makes a bacteria a probiotic? Three checks What are LAFTI® probiotics? Second-generation probiotics LAFTI® probiotics are second-generation probiotics. The first probiotic strains were isolated many decades ago without insight into strainrelated characteristics and their efficacy was not always predictable or repeatable. Additionally, many ‘probiotics’ currently available in the market place lack the (strain-specific) scientific evidence to demonstrate the health benefits. What makes LAFTI® probiotics special? They bring the latest discoveries in the field of probiotics The second-generation screening strategy has resulted in unique benefits such as stability, survival and probiotic health effects (see picture below). Second-generation LAFTI® probiotics, conversely, have built on knowledge amassed over the years. LAFTI® probiotics are the result of sophisticated screening of a large number of bacteria with potential probiotic effects. LAFTI® second-generation probiotics have recently been selected using today’s scientific techniques that focus on probiotic properties that are now known to be important. LAFTI®’s unique benefits include: Superior stability In order to deliver health benefits, probiotics must be alive when they arrive at their final destination: the intestines. Heat, moisture, long shelf life and inadequate packaging of the final product can all easily inactivate probiotics, resulting in inferior consumer products. LAFTI® probiotics have been particularly developed to minimise the difficulties associated with stability. Back.. Proven health effects LAFTI® probiotics assist the immune system via protection against ‘bad’ bacteria such as Listeria and Salmonella. Also, clinical studies in humans have been completed. These support LAFTI® as having a beneficial effect on the general feeling of well being and control of irritable bowel syndrome. Excellent survival Before arriving at their final destination, probiotics must pass through the digestive system, including the stomach. The acidic stomach and bile in the digestive system can easily inactivate probiotics. LAFTI® second-generation probiotics have been specifically screened for acid and bile resistance and survival in the human digestive system. High concentration LAFTI® probiotics are available in very high concentrations, enabling for example dietary supplement manufacturers to create cost-effective supplements which are also efficacious. These probiotics can be blend with other ingredients such as prebiotics, vitamins and minerals, and they allow consumers to take their daily dose of probiotics in a single capsule. Safety All LAFTI® strains are safe to use in every application. Scientific information Numerous studies have been undertaken which support the positive effects of probiotic microbial population. Choice of strain depends on the desired health DSM’s understanding of probiotic cultures, combined with extensive and continuing in vivo and in vitro research ensures that the LAFTI® range provides an optimal combination of important benefits of the application. probiotic properties with data available to To claim efficacy beyond the point of DSM will continue to provide scientific manufacture, probiotics must remain stable throughout shelf life and in the gastro-intestinal tract where they are designed to take effect. Our studies have shown that LAFTI® survives well in the human gastro-intestinal tract. Sophisticated strain selection is key to probiotic performance. DSM secondgeneration LAFTI® strains are specially selected and formulated to meet the dual demands of stability and survival, delivering positive probiotic effects to humans. Clinical trials have been completed which show that LAFTI® products are effective probiotics. These trials indicated promising results, for example a beneficial effect on the general feeling of well being and control of irritable bowel syndrome. Other studies have shown that all three LAFTI® strains inhibit a range of pathogenic bacteria in vitro. support product and labelling claims. backing for all LAFTI® strains and support customers with advice and support in product development and labeling. Literature information is available from DSM upon request.