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The Medical Journal of Australia
The Medical Journal of Australia

... symptom onset) to a facility without PCI capability, it is appropriate to consider transfer for primary PCI if balloon inflation can be achieved within 2 hours (including transport time). • All PCI facilities should be able to perform angioplasty within 90 minutes of patient presentation. • Fibrinol ...
Cardiovascular Drift During Prolonged Exercise: New Perspectives
Cardiovascular Drift During Prolonged Exercise: New Perspectives

... It is quite possible that the large elevation in plasma norepinephrine experienced during exercise when dehydrated and hyperthermic is related to cutaneous vasoconstriction (4,6). The fact that the cutaneous circulation experiences vasoconstriction during hyperthermia suggests that the CV system is ...
Obstructive Sleep Apnea and Cardiovascular Disease
Obstructive Sleep Apnea and Cardiovascular Disease

... • Personal financial interests in commercial entities that are relevant to my presentation(s) or other faculty roles: • No relevant commercial interests ...
CHAPTER 18 MS Cardiovascular System
CHAPTER 18 MS Cardiovascular System

... The job of the blood vessels is to move the blood around the body. There are three main types of blood vessels in the body. a. Arteries are blood vessels that carry blood away from the heart. Arteries have thick walls that have a layer of smooth muscle, as shown in Figure 18.3 . Arteries usually car ...
The second peak of the radial artery pressure wave represents
The second peak of the radial artery pressure wave represents

... and second systolic de¯ections, and con®rmation of the relationship between aortic pressure and the second radial wave.4 Then, it would be seen that the lowering effect of vasodilator treatment on the aortic pressure agreed with that on the second radial wave. We have also derived aortic SP from dig ...
salt in hypertension and heart failure
salt in hypertension and heart failure

... of Hypertension Prevention (TOHP) II also showed that salt restriction combined with weight reduction had a greater effect on reducing the incidence of hypertension during the first 6 months of the study in overweight people with high-normal BP. However, this effect did not sustain over the followin ...
Heart failure highlights in 20122013
Heart failure highlights in 20122013

... only are co-morbidities frequently present in patients with HF, but their presence is also associated with an increased risk for death and rehospitalizations for HF. Among known co-morbidities, renal dysfunction is now a well-established and important co-morbidity. However, the prediction of deterio ...
state of michigan michigan administrative hearing system
state of michigan michigan administrative hearing system

... history of light exertional, unskilled unemployment, using Vocational Rule 202.04. SHRT denied Claimant’s Retro-MA application using Vocational Rule 202.13 as a guide from 12/2010, the requested date of retroactive MA. (Department Exhibit C, pages 1-2). ...
Apolipoprotein A-IMilano and 1-Palmitoyl-2
Apolipoprotein A-IMilano and 1-Palmitoyl-2

... total LV (p ⬍ 0.05) compared with rabbits treated with vehicle (Fig. 2C). Note that two treatments (chronic) had no apparent advantage over a single treatment (acute) for cardioprotection. In the second protocol, the minimal effective dose was found using the single-treatment protocol (acute) was us ...
Left Atrial Appendage: Useless or Priceless?
Left Atrial Appendage: Useless or Priceless?

... patients with atrial flutter for the presence of thrombi in the left atrial appendage (LAA) using transesophageal echocardiography (TEE). They found no thrombi in patients with atrial flutter nor in those with lone atrial fibrillation; however, they did observe thrombi in 17% of afibbers whose AF di ...
Brief pressure overload of the left ventricle reduces myocardial
Brief pressure overload of the left ventricle reduces myocardial

... The mechanisms of ischemic preconditioning have been extensively investigated. Activation of protein kinase C (PKC) has been reported to play an important role in ischemic preconditioning protection.12e15 Administration of PKC activators mimics ischemic preconditioning and decreases MI size.13,15 So ...
Thrombus Aspiration during Percutaneous coronary intervention in
Thrombus Aspiration during Percutaneous coronary intervention in

... lumen of an over the wire balloon system is just large enough to allow passage of 0.014-in wire, which may not allow rapid aspiration. Use of the angiography catheter as an aspiration tool is limited by the inability to manipulate it deeply enough into the infarct-related artery to approach the culp ...
Apolipoprotein A-IMilano and 1-Palmitoyl-2-oleoyl
Apolipoprotein A-IMilano and 1-Palmitoyl-2-oleoyl

... total LV (p ⬍ 0.05) compared with rabbits treated with vehicle (Fig. 2C). Note that two treatments (chronic) had no apparent advantage over a single treatment (acute) for cardioprotection. In the second protocol, the minimal effective dose was found using the single-treatment protocol (acute) was us ...
Unoperate shunt lesions in adults: when is closure indicated?
Unoperate shunt lesions in adults: when is closure indicated?

... shunt, RV size and function, TR and PAP by echocardiography as well as of arrhythmias by history, ECG and only if indicated (not routinley) Holter ● Late post-op. arrhythmias after surgical repair at age <40 years are most frequently intraatrial reentrant tachycardia or atrial flutter which can be s ...
Effect of Mean Circulatory Filling Pressure and Other
Effect of Mean Circulatory Filling Pressure and Other

... to blood viscosity. It is quite interesting that in clinical patients with severe anemia, in whom the viscosity of the blood may be decreased by a factor of some two to three times, the cardiac output is increased roughly in proportion to the decrease (IO). Obviously, other factors, in viscosity suc ...
Modelling in the study of interaction of Hemopump device and
Modelling in the study of interaction of Hemopump device and

... the pump almost as safe and convenient as the IABP. This pump may be more effective than IABP in assisting failing left ventricle [1]. In contrast to IABP, this kind of ventricular assist device is not synchronized with the patient’s ECG and therefore works properly even during arrhythmia or cardiac ...
Essential tools for diagnosis of feline heart disease and heart failure
Essential tools for diagnosis of feline heart disease and heart failure

... may be assessed using pulsed wave Doppler of the mitral inflow and pulmonary venous flow. Delayed relaxation or restrictive patterns may be identified which denote worsening stages of diastolic dysfunction respectively. However, there is an intermediate flow pattern termed “pseudonormalization” whic ...
NIH Public Access
NIH Public Access

... literature, we conclude that most patients will benefit from its use. Indeed, the clinical data suggest that, in addition to being safe, moderate levels of PEEP may provide haemodynamic and oxygenation benefits in LV failure exhibiting afterload-dependent physiology. However, in certain scenarios, e ...
Effect of Mean Circulatory Filling Pressure and
Effect of Mean Circulatory Filling Pressure and

... to blood viscosity. It is quite interesting that in clinical patients with severe anemia, in whom the viscosity of the blood may be decreased by a factor of some two to three times, the cardiac output is increased roughly in proportion to the decrease (IO). Obviously, other factors, in viscosity suc ...
Human cardiac high-energy phosphate metabolite concentrations
Human cardiac high-energy phosphate metabolite concentrations

... the infarcted ones (6). The surviving myocytes may exhibit high-energy phosphate metabolites in essentially normal proportions or in proportions altered b y heart failure or other dysfunction (6, 9). In this picture, the mere presence of metabolite in a region of tissue is indicative of living or vi ...
Risk Stratification for Sudden Cardiac Death after Acute Myocardial
Risk Stratification for Sudden Cardiac Death after Acute Myocardial

... myocardial infarction (AMI) are started on medication with proven prognostic benefit [e.g. β-blockers, angiotensin converting enzyme (ACE)-inhibitors and statins] and undergo coronary angiography with revascularisation as dictated by their presentation and symptoms. Despite these measures, evidence ...
N-terminal pro B-type natriuretic peptide (NT
N-terminal pro B-type natriuretic peptide (NT

... Although BNP has potent natriuretic and diuretic effects, paradoxically in heart failure there is congestion, sodium retention and oedema. Recent studies have proposed that this is due to insufficient post-translational maturation of the biosynthetic precursors (Goetze JP et al. Eur Heart J 2003; 24 ...
The Effect of Opium Addiction on Arrhythmia Following Acute
The Effect of Opium Addiction on Arrhythmia Following Acute

... participants were classified into two groups with opium addiction (n=94) and without opium addiction (n=106). Post-MI arrhythmias were determined among each group. Study populations were included all patients with first AMI admitted within 6 hours of the onset of chest pain to coronary care units (C ...
The Responses of Cardiac Sympathetic Nerve Activity to Changes in
The Responses of Cardiac Sympathetic Nerve Activity to Changes in

... while volume expansion was associated with a significant decrease in CSNA. In contrast, both these responses were severely blunted in HF, with no significant changes in CSNA during either hemorrhage or volume expansion. Decreases in cardiac filling pressures in normal animals The present finding tha ...
2016 ESC Cardio oncology
2016 ESC Cardio oncology

... Although the field of cardio-oncology has received increasing attention in recent years, many aspects of both radiation-induced and cancer drug– induced CVD are still to be fully elucidated. Furthermore, the inability to predict the long-term consequences of cancer treatment –associated cardiovascul ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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