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Abridged version of the expert consensus document on arterial
Abridged version of the expert consensus document on arterial

... notch on the skin) and near the bifurcation of the abdominal aorta (i.e. umbilicus level on the skin). Transit time is automatically calculated following automatic recognition of the foot of the pulse. This method was used for showing the predictive value of aortic PWV for cardiovascular events in d ...
Patient Selection in Heart Failure With Preserved Ejection Fraction
Patient Selection in Heart Failure With Preserved Ejection Fraction

... thought that HFpEF was primarily a disease of elderly women with stiff left ventricles from longstanding hypertension and concomitant diabetes mellitus. However, clinical trials, cohort studies, and registry analyses have demonstrated that the HFpEF population is heterogeneous, particularly with res ...
fontan circulation
fontan circulation

... Kouatli et al ,Enalapril does not enhance exercise capacity in patients after Fontan procedure. Circulation Sep 2 1997;96(5):1507–12. ...
Risk assessment in patients with an acute ST
Risk assessment in patients with an acute ST

... complication of STEMI and has been known to be an independent strong predictor of long-term mortality  [13] . However, no studies have proven that mitral regurgitation in STEMI is associated with adverse short-term clinical outcomes. Acute septal rupture is a life threatening complication that can p ...
Metformin Actavis 500 mg film
Metformin Actavis 500 mg film

... followed by coma. Diagnostic laboratory findings are decreased blood pH, plasma lactate levels above 5 mmol/L, and an increased anion gap and lactate/pyruvate ratio. In case of lactic acidosis, the patient should be hospitalised immediately (see section 4.9). Physicians should alert the patients on ...
Metformin Actavis 850 mg film
Metformin Actavis 850 mg film

... followed by coma. Diagnostic laboratory findings are decreased blood pH, plasma lactate levels above 5 mmol/L, and an increased anion gap and lactate/pyruvate ratio. In case of lactic acidosis, the patient should be hospitalised immediately (see section 4.9). Physicians should alert the patients on ...
Remote Ischemic Conditioning Reduces Myocardial Infarct Size and
Remote Ischemic Conditioning Reduces Myocardial Infarct Size and

... BACKGROUND RIC, using transient limb ischemia and reperfusion, can protect the heart against acute ischemiareperfusion injury. Whether RIC can reduce MI size, assessed by cardiac magnetic resonance (CMR), is unknown. METHODS We randomly assigned 197 ST-segment elevation myocardial infarction patient ...
Impact of Diabetes Mellitus on Radial and Ulnar Arterial
Impact of Diabetes Mellitus on Radial and Ulnar Arterial

... of whom completed the study. Demographic and baseline clinical characteristics of 40 non-DM and 40 DM human patients are presented in Table 1. Patients with DM showed a higher incidence of accompanied hypertension than non-DM patients (98% vs. 78%, respectively; P = 0.021) and had, on average, exper ...
ventricular septal defect in infants and children with increased
ventricular septal defect in infants and children with increased

... is one of the most common open heart procedure performed in paediatric cardiac surgery 1 . Large VSD with large left to right shunts commonly present in infants with respiratory symptoms and poor growth 2 . Large VSD usually results in PVR in later life. The closure of a large VSD is performed in de ...
heart
heart

... Table 2. Crude and Adjusted Hazard Ratios (95% Confidence Intervals) for Various Outcomes in Older Adults With Systolic Versus Diastolic Heart Failure ...
Reduction of Canine Myocardial Infarct Size by a Diffusible Reactive
Reduction of Canine Myocardial Infarct Size by a Diffusible Reactive

... Another disappointing aspect of efforts to reduce reperfusion injury has been that agents that appear to reduce myocardial injury if given before ischemia have generally failed to do so if they are given near the onset of reperfusion.14,15,17-19 This is troubling, since clinical application of an in ...
On Coupling a Lumped Parameter Heart Model and a Three
On Coupling a Lumped Parameter Heart Model and a Three

... different flow or pressure waveform needs to be constructed based on available literature data. Fundamentally, aortic blood flow and pressure result from the interactions between the heart and arterial system. The aortic flow and pressure change as the cardiac properties change and vice versa. To study ...
CD36 Mediates the Cardiovascular Action of Growth Hormone
CD36 Mediates the Cardiovascular Action of Growth Hormone

... a hexapeptide of the GHRP family, has reported cardiovascular activity. To identify the molecular target mediating this activity, rat cardiac membranes were labeled with a radioactive photoactivatable derivative of hexarelin and purified using lectin affinity chromatography and preparative gel elect ...
Obstructive Sleep Apnea
Obstructive Sleep Apnea

... nonalcoholic fatty liver disease. In patients with the metabolic syndrome, the prevalence of moderate to severe OSA is very high (w60%). In this population, OSA is independently associated with increased glucose and triglyceride levels as well as markers of inflammation, arterial stiffness, and ather ...
Randomized, Double-Blind Placebo-Controlled Trial of
Randomized, Double-Blind Placebo-Controlled Trial of

... myocardial contractility after coenzyme Q supplementation during ischemia-reperfusion injury was observed. Recent studies [9] indicate that coenzyme Q can inhibit platelet aggregation and human vitronectin receptor expression [10], which are important predisposing mechanisms of coronary thrombosis a ...
Congenital Heart Defects Left-to-Right Shunt Lesions by Prof Dr
Congenital Heart Defects Left-to-Right Shunt Lesions by Prof Dr

... that are associated with an increased chance of getting congenital heart disease. These risk factors include: • Genetic or chromosomal abnormalities in the child such as Down syndrome. • Taking certain medications or alcohol or drug abuse during pregnancy. • Maternal viral infection, such as rubella ...
Coronary Sinus
Coronary Sinus

... the main artery was totally occluded for a period of six months. Patency was observed throughout the arterial system down to the smallest arterioles. The degree of medial sclerosis of arteries was greatest in the larger arteries and least in the smaller arteries. Veins. The coronary sinus was dilate ...
2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management... Heart Failure in Adults: A Report of the American College...
2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management... Heart Failure in Adults: A Report of the American College...

... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
Practice Guideline: Focused Update 2009 Focused Update
Practice Guideline: Focused Update 2009 Focused Update

... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
Effect of Hypertonic Saline on the Pulmonary and Systemic Pressures
Effect of Hypertonic Saline on the Pulmonary and Systemic Pressures

... rapid intravenous injection of a 20 per cent saline solution causes a very marked rise in pressure in the pulmonary veins, the pulmonary artery, the right heart and the peripheral veins. Left atrial pressure either does not change or decreases, and aortic pressure f alls to very low levels. Apnea an ...
Clyde W. Yancy Donna M. Mancini, Peter S. Rahko, Marc A. Silver
Clyde W. Yancy Donna M. Mancini, Peter S. Rahko, Marc A. Silver

... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
STUDIES ON THE CONSECUTIVE PHASES OF THE CARDIAC
STUDIES ON THE CONSECUTIVE PHASES OF THE CARDIAC

... English writers but it has been more difficult to find a concise and accurate term by which to designate the Anspannungszeit. The ph.rase“period of rising tension” is too long and the term “presphygmic period” is unfortunately inaccurate since, as Frank (7) first showed, there is a well-marked sphyg ...
Downloaded
Downloaded

... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
Effects of Epinephrine on Frog Ventricle
Effects of Epinephrine on Frog Ventricle

... pressure drop between the heart container and beaker was used to measure the flow rate. The extracardiac pressures (within heart container) and the lateral isotonic pressures were recorded by means of 2 Statham gages (F and G) and a Hathaway recorder with a paper speed of either 4 or 10 inches per s ...
Electrocardiographic criteria of left ventricular hypertrophy in general
Electrocardiographic criteria of left ventricular hypertrophy in general

... Kaplan–Meier survival curves. Relative risk (RR) of LVH as diagnosed with the different criteria was calculated, together with 95% confidence intervals (CI), from Cox multivariate analysis including as covariables body mass index, smoking, alcohol, serum lipids, diabetes and—when proper-age and gend ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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