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Role of an ATP-Sensitive Potassium Channel Opener, YM934, in
Role of an ATP-Sensitive Potassium Channel Opener, YM934, in

... Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan Accepted for publication July 23, 1999 ...
Exercise training and chronic heart failure
Exercise training and chronic heart failure

... prognostic factors, exercise training was associated with a statistically significant 15% decrease in all-cause mortality and CHF hospitalisations. It is important to acknowledge that this study yielded only modest overall gains in V̇O2 peak, and small increases in 6-min walk test (6MWT) distance. A ...
J Soler-Soler, J Sagristá-Sauleda, A Cabrera, J Sauleda-Parés, J Iglesias-Berengué,... Permanyer-Miralda and J Roca-Llop
J Soler-Soler, J Sagristá-Sauleda, A Cabrera, J Sauleda-Parés, J Iglesias-Berengué,... Permanyer-Miralda and J Roca-Llop

... rate and on any associated cardiac anomaly. Although prognosis is usually good,'6' 20, 25 isolated fatal cases have been reported.26'2,27 In some series 16,282 mortality iis 2-11%, and death is related to heart failure or to complications of therapy. Digitalis, considered to be the first-choice drug ...
WEDNESDAY, September 2
WEDNESDAY, September 2

... “Advances in Cardiovascular Research”, which will be held in Smolenice Castle, the Congress Centre of the Slovak Academy of Sciences. The Symposium will offer an opportunity to bring together renowned scientists; clinicians, as well as basic scientists from all areas of cardiovascular research, the ...
Cardiovascular Biomechanics
Cardiovascular Biomechanics

... remaining blood and “prime” ventricular pump. ...
Aortic diameter and pressure-flow sequence identify
Aortic diameter and pressure-flow sequence identify

... ventricular and aortic pressures during vest and high impulse cardiopulmonary resuscitation were attributable to a flail chest, which developed in one of the seven dogs studied and which may have allowed direct compression of the heart. In the remaining six dogs, including two others in which flail ...
Adverse effects
Adverse effects

... • It can occasionally cause either hypo or hyperthyroidism • It has high lipid solubility & tends to accumulate extensively in adipose (fat) tissue and highly perfused organs such as the liver, lungs and spleen • It can produce lung damage directly by a cytotoxic effect and indirectly by an immunolo ...
association between plasma homocysteine and suspected myocardial ischaemia
association between plasma homocysteine and suspected myocardial ischaemia

... patients with elevated homocysteine levels compared to those with normal homocysteine levels. This again suggests that higher homocysteine levels are seen in patients with established and more extensive disease, often resulting in a dilated left ventricle and reduced left ventricular pump efficacy. ...
Chapter 13
Chapter 13

... The vasomotor center of the medulla oblongata can adjust the sympathetic impulses to smooth muscles in arteriole walls, adjusting blood pressure. a. Certain chemicals, such as carbon dioxide, oxygen, and hydrogen ions, can also affect ...
Diastolic Dysfunction and Diastolic Heart Failure By Mohammad M
Diastolic Dysfunction and Diastolic Heart Failure By Mohammad M

... Patients with diastolic HF have a marked limitation in exercise tolerance. This could be due to: -The inability mechanism. ...
Circulatory support
Circulatory support

... However, it should be noted that in patients with borderline hemodynamics, ongoing ischemia, or cardiogenic shock, insertion of an intra-aortic balloon just prior to coronary instrumentation has been associated with improved outcomes. Furthermore it is reasonable to obtain vascular access in the con ...
Iabp2
Iabp2

... However, it should be noted that in patients with borderline hemodynamics, ongoing ischemia, or cardiogenic shock, insertion of an intra-aortic balloon just prior to coronary instrumentation has been associated with improved outcomes. Furthermore it is reasonable to obtain vascular access in the con ...
Coronary Heart Disease - University of Warwick
Coronary Heart Disease - University of Warwick

... stressors (Kop et al., 2001). If heart rate provides an index of oxygen demand, then effects of mental stress on ischemia occur during relatively low demand. This suggests that mental stress may also reduce cardiac oxygen supply. Both human and animal investigations have demonstrated mechanisms invo ...
Review - p - the Health Science Program
Review - p - the Health Science Program

... 6. Cheating of any kind will not be tolerated, including but not limited to: consulting text books, notes or web sites; discussing or reviewing any items on the exam with anyone else during the exam period; and talking to other students during the exam. If the exam monitor suspects anyone of talking ...
2000 The European Society of Cardiology
2000 The European Society of Cardiology

Atrial Fibrillation in the 21st Century: A Current Understanding of
Atrial Fibrillation in the 21st Century: A Current Understanding of

... age-related increase in the risk of stroke in patients with AF, ranging from 1.5% at age 50 to 59 years to 23.5% at age 80 to 89 years.7 Despite established associations between AF and other cardiovascular (CV) disease processes, such as coronary heart disease (CHD), type 2 diabetes mellitus (T2DM), ...
Left Ventricular Assist Device as Permanent Support in Patients with
Left Ventricular Assist Device as Permanent Support in Patients with

... heart failure and signs typical of heart failure and objective signs of a structural or functional abnormality of the heart at rest. (European Society of Cardiology 1995) The syndrome is characterized by inability of the heart to maintain adequate blood flow and/or normal filling pressures during ph ...
Slow and deep respiration suppresses steady
Slow and deep respiration suppresses steady

... been diverse findings about respiratory influences on steadystate sympathetic nerve activity. However, these studies included healthy or mildly hypertensive subjects with relatively lower sympathetic nerve activity at rest or during handgrip exercise or lower body negative pressure (8, 18). The magn ...
Elevated Blood Pressure, Decreased Heart Rate Variability and
Elevated Blood Pressure, Decreased Heart Rate Variability and

... cardiovascular disease (CVD)1–3). Working shifts impacts on the cardiovascular (CV) system of workers. These are measurable impacts which are supported by a number of epidemiologic studies1, 2). Yet empirical data as to their pathophysiology are quite limited. A recent review of the data shows that ...
Pressure overload alters stress-strain properties of the developing
Pressure overload alters stress-strain properties of the developing

... 40). Similar and reduced LV stress-strain relations have been reported after ventricular pressure overload ...
RàL - WordPress.com
RàL - WordPress.com

... Acute L heart obstruction (eg. AS, COA  incr afterload; will present in 1st 1/52) 1Y myocardial  decr inotropic function (eg. Cardiomyopathy, myocarditis; can present at any age) Other (eg. Anaemia, metabolic, toxic; usually presents on D1, unlike other causes) Sx: SOB after feeding, poor feeding, ...
Clinical Cardiology: New Frontiers
Clinical Cardiology: New Frontiers

... found to lower blood pressure. In mildly hypertensive men, short-term physical activity decreased blood pressure for 8 to 12 hours after exercise, and average blood pressure was lower on exercise than on nonexercise days.26 In hypertensive black men, moderate physical activity performed for 16 to 32 ...
Detection of scarred and viable myocardium using a new magnetic
Detection of scarred and viable myocardium using a new magnetic

... there is persistently impaired left ventricular contraction at rest which can be restored partially or completely to normal after revascularisation.1 2 Hibernation is a state of adaptation of the myocardium that acts as endogenous protection against ischaemia, preserving the structural integrity of ...
Ultrasonographic Measurement of Carotid Intimal
Ultrasonographic Measurement of Carotid Intimal

... systematic reviews of these cohort studies. The following review includes the largest prospective cohort studies and the most important systematic reviews of these studies. A summary of the key literature follows. PROGNOSTIC VALUE Systematic Reviews In 2010, Mookadam et al conducted a systematic rev ...
9. cardiac cycle and heart sounds
9. cardiac cycle and heart sounds

... them  to  vibrate  for  longer  Fme.   •  The  2nd  heart  sound  had  higher  frequency  due  to     –  The  semilunar  valves  are  more  taut   –  The  great  elasFc  coefficient  of  the  taut  arteries  which   provides  the  princ ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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