LRRC10 is required to maintain cardiac function in - AJP
... cardiac output and reduce ventricular wall stress (20, 23, 38). While initially beneficial, prolonged cardiac hypertrophy becomes maladaptive and progresses to cardiac dilation, decompensation, heart failure, and/or sudden death (20, 23, 38). Cardiac hypertrophy can be induced by a number of cardiov ...
... cardiac output and reduce ventricular wall stress (20, 23, 38). While initially beneficial, prolonged cardiac hypertrophy becomes maladaptive and progresses to cardiac dilation, decompensation, heart failure, and/or sudden death (20, 23, 38). Cardiac hypertrophy can be induced by a number of cardiov ...
clinically applicable alternative to Emax
... volume. Late in the diastole, the ventricle fills passively and is often aided by pressure developed in the atrium to push blood through the atrio-ventricular valves into the ventricle. Clinical evaluation and or diagnosis of heart failure involve quantifying systolic function as well as diastolic f ...
... volume. Late in the diastole, the ventricle fills passively and is often aided by pressure developed in the atrium to push blood through the atrio-ventricular valves into the ventricle. Clinical evaluation and or diagnosis of heart failure involve quantifying systolic function as well as diastolic f ...
Cardiac diastolic function and hypercapnic ventilatory responses in central sleep apnoea
... the hallmark feature of both types of CSA, has previously been attributed to either increased pulmonary vagal afferent-nerve activity due to pulmonary hypertension [9, 11–14] or increased ventilatory responses to CO2 [5–8]. Subjects with CHF-CSA are thought to have both mechanisms operating [6–8, 14 ...
... the hallmark feature of both types of CSA, has previously been attributed to either increased pulmonary vagal afferent-nerve activity due to pulmonary hypertension [9, 11–14] or increased ventilatory responses to CO2 [5–8]. Subjects with CHF-CSA are thought to have both mechanisms operating [6–8, 14 ...
Systolic and Diastolic Heart Failure: Differences and Similarities Review Articles
... dilatation of the heart with blood: opposed to systole, or contraction.’’ Conventionally, the closure of the aortic valve is regarded to indicate the onset of diastole as it indicates the onset of ventricular relaxation phase.3 Because left ventricular ejection influences relaxation and the rapid fi ...
... dilatation of the heart with blood: opposed to systole, or contraction.’’ Conventionally, the closure of the aortic valve is regarded to indicate the onset of diastole as it indicates the onset of ventricular relaxation phase.3 Because left ventricular ejection influences relaxation and the rapid fi ...
Physiological and pathological cardiac hypertrophy induce different
... Recently, it has been reported that some cardiovascular regulating factors participate in pathological cardiac hypertrophy (27). Recent in vivo studies have suggested that ANG II is a growth factor for pathological cardiac hypertrophy (16, 40). ANG II is converted from ANG I by angiotensin-convertin ...
... Recently, it has been reported that some cardiovascular regulating factors participate in pathological cardiac hypertrophy (27). Recent in vivo studies have suggested that ANG II is a growth factor for pathological cardiac hypertrophy (16, 40). ANG II is converted from ANG I by angiotensin-convertin ...
Heart size-independent analysis of myocardial
... connected to a rodent ventilator after endotracheal intubation (7). Anesthesia was maintained by the administration of 0.5–1.0% isoflurane. After bilateral vagotomy, cardiac catheterization was performed with a 1.4-Fr high-fidelity micromanometer catheter inserted retrograde through the right caroti ...
... connected to a rodent ventilator after endotracheal intubation (7). Anesthesia was maintained by the administration of 0.5–1.0% isoflurane. After bilateral vagotomy, cardiac catheterization was performed with a 1.4-Fr high-fidelity micromanometer catheter inserted retrograde through the right caroti ...
G. Secondary Prevention of Stroke Educational Supplement
... Therapy with a diuretic, alone or in combination with ACE inhibitor, could be recommended based on available data (Hilleman and Lucas 2004). However, individual cases may not respond equally to the same treatment and reduction and control of BP may require the use of multiple antihypertensive agents ...
... Therapy with a diuretic, alone or in combination with ACE inhibitor, could be recommended based on available data (Hilleman and Lucas 2004). However, individual cases may not respond equally to the same treatment and reduction and control of BP may require the use of multiple antihypertensive agents ...
Artificial ventilation simulator
... alveolar pressure, and the gas flows inside the lungs, whereas during expiration the process is reversed. The result is positive intrathoracic pressure, which cancels the thoracic pump effect. Moreover, increased lung volume extends pulmonary capillaries [2], therefore reduces their diameter and ele ...
... alveolar pressure, and the gas flows inside the lungs, whereas during expiration the process is reversed. The result is positive intrathoracic pressure, which cancels the thoracic pump effect. Moreover, increased lung volume extends pulmonary capillaries [2], therefore reduces their diameter and ele ...
Screening for Cardiovascular Disease and Risk Factors
... Cardiovascular disease is a leading cause of morbidity and mortality worldwide. In 2008, ischaemic heart disease and cerebrovascular disease accounted for 3.5% and 2.1% of all hospital discharges; and 20.1%, and 8.3% of total causes of death respectively in Singapore. Cardiovascular disease is a con ...
... Cardiovascular disease is a leading cause of morbidity and mortality worldwide. In 2008, ischaemic heart disease and cerebrovascular disease accounted for 3.5% and 2.1% of all hospital discharges; and 20.1%, and 8.3% of total causes of death respectively in Singapore. Cardiovascular disease is a con ...
Cardiorenal Syndromes: Advances in Determining Diagnosis
... In terms of medicinal therapy, several classes of agents have favorable effects on both the heart and the kidneys primarily in the setting of chronic management. It has been long-recognized that agents that antagonize the renin-angiotensin system in general have beneficial effects on both the heart ...
... In terms of medicinal therapy, several classes of agents have favorable effects on both the heart and the kidneys primarily in the setting of chronic management. It has been long-recognized that agents that antagonize the renin-angiotensin system in general have beneficial effects on both the heart ...
ESC Guidelines for the management of grown
... Page 4 of 43 The finalized document has been approved by all the experts involved in the Task Force, and was submitted to outside specialists for review. The document was revised, and finally approved by and subsequently published in the European Heart Journal. After publication, dissemination of t ...
... Page 4 of 43 The finalized document has been approved by all the experts involved in the Task Force, and was submitted to outside specialists for review. The document was revised, and finally approved by and subsequently published in the European Heart Journal. After publication, dissemination of t ...
Obesity/Metabolic Syndrome
... associated with myocardial contractile disturbances. However, a cause-effect relationship between obesity and cardiac systolic dysfunction is controversial. Indeed, weight loss produced by lifestyle modification or gastric bypass does not influence left ventricular (LV) myocardial systolic dysfuncti ...
... associated with myocardial contractile disturbances. However, a cause-effect relationship between obesity and cardiac systolic dysfunction is controversial. Indeed, weight loss produced by lifestyle modification or gastric bypass does not influence left ventricular (LV) myocardial systolic dysfuncti ...
The Evolving Role of BNP in the Diagnosis and
... performed in roughly half, at the physician’s choice. Patients were randomized into four blinded groups, each receiving standard therapy and: fixed dose nesiritide, titratable nesiritide, titratable nitroglycerin, or placebo. Nesiritide had a faster onset and greater reduction in PCWP than nitroglyc ...
... performed in roughly half, at the physician’s choice. Patients were randomized into four blinded groups, each receiving standard therapy and: fixed dose nesiritide, titratable nesiritide, titratable nitroglycerin, or placebo. Nesiritide had a faster onset and greater reduction in PCWP than nitroglyc ...
Cardiac contractility modulation by electric currents - AJP
... might have application as a therapy for heart failure. It has recently been demonstrated (3) that extracellularly applied electric signals have a similar effect as voltage clamping in muscles isolated from normal animals and failing human hearts. In addition, when applied regionally, electrical curr ...
... might have application as a therapy for heart failure. It has recently been demonstrated (3) that extracellularly applied electric signals have a similar effect as voltage clamping in muscles isolated from normal animals and failing human hearts. In addition, when applied regionally, electrical curr ...
Poor R-Wave Progression
... disease in an asymptomatic 46-year-old female insurance applicant with no risk factors is approximately 1%.8 Therefore, the likelihood, that such an individual’s ECG actually represents an old myocardial infarction is very low. What other possibilities could be responsible for the poor R-wave progre ...
... disease in an asymptomatic 46-year-old female insurance applicant with no risk factors is approximately 1%.8 Therefore, the likelihood, that such an individual’s ECG actually represents an old myocardial infarction is very low. What other possibilities could be responsible for the poor R-wave progre ...
AFA Ablation for AF Booklet.indd
... The purpose of a catheter ablation is to stop the rogue electrical pulses that cause atrial fibrillation. These are found in the left atria, most commonly close to or around the pulmonary veins. To achieve this, small areas of the tissue within the left atria are destroyed, commonly using either hea ...
... The purpose of a catheter ablation is to stop the rogue electrical pulses that cause atrial fibrillation. These are found in the left atria, most commonly close to or around the pulmonary veins. To achieve this, small areas of the tissue within the left atria are destroyed, commonly using either hea ...
Resistance With Elevated Pulmonary Vascular Evaluation of
... each followed by hemodynamic measurements and sampling for arterial and mixed venous oxygen content. The experimental period of spontaneous breathing procedure started with a control at an inspiratory fraction of oxygen of 30% via a tightfitting face mask in a nonrebreathing system. After baseline h ...
... each followed by hemodynamic measurements and sampling for arterial and mixed venous oxygen content. The experimental period of spontaneous breathing procedure started with a control at an inspiratory fraction of oxygen of 30% via a tightfitting face mask in a nonrebreathing system. After baseline h ...
The AHA Guidelines Including Pediatric Resuscitation
... not available, then an AED without a dose attenuator may be used, but this is the third choice. In the previous guidelines, there was insufficient data to recommend for or against the use of an AED in infants so this is a new recommendation for infants (<1 year of age). The 2010 recommendation for A ...
... not available, then an AED without a dose attenuator may be used, but this is the third choice. In the previous guidelines, there was insufficient data to recommend for or against the use of an AED in infants so this is a new recommendation for infants (<1 year of age). The 2010 recommendation for A ...
The effect of positive end-expiratory pressure on pulse pressure variation Original Research:
... Objectives: To determine the effect of different levels of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV). Design: An observational study. Setting: Operating theatres of a tertiary training hospital. Subjects: Ventilated patients who required intra-arterial blood pressure ...
... Objectives: To determine the effect of different levels of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV). Design: An observational study. Setting: Operating theatres of a tertiary training hospital. Subjects: Ventilated patients who required intra-arterial blood pressure ...
2012 focused update of the ESC Guidelines
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
2012 focused update of the ESC Guidelines for the management of
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
... and a three-fold incidence of congestive heart failure, and higher mortality. Hospitalization of patients with AF is also very common. This arrhythmia is a major cardiovascular challenge in modern society and its medical, social and economic aspects are all set to worsen over the coming decades. For ...
Executive Summary - European Society of Cardiology
... This document was approved by the American College of Cardiology Foundation Board of Trustees in August 2006, by the American Heart Association Science Advisory and Coordinating Committee in July 2006, and by the European Society of Cardiology Committee for Practice Guidelines in July 2006. When cit ...
... This document was approved by the American College of Cardiology Foundation Board of Trustees in August 2006, by the American Heart Association Science Advisory and Coordinating Committee in July 2006, and by the European Society of Cardiology Committee for Practice Guidelines in July 2006. When cit ...
Increased Soluble ST2 Predicts Long-term Mortality in Patients with
... biochemical and genetic risk factors for CAD in a hospital-based cohort of white individuals referred to coronary angiography and to evaluate the predictive value of potential markers on long-term outcome. LURIC study objectives, recruitment procedures, and characteristics have been described in det ...
... biochemical and genetic risk factors for CAD in a hospital-based cohort of white individuals referred to coronary angiography and to evaluate the predictive value of potential markers on long-term outcome. LURIC study objectives, recruitment procedures, and characteristics have been described in det ...
infarction: a corollary to infarct expansion
... significant valvular disease, or cardiomyopathy were not considered. Informed consent was obtained from each patient after an appropriate explanation of risks and potential complications of the proposed study. Cardiac catheterization Protocol. Cardiac catheterization was performed at the time of adm ...
... significant valvular disease, or cardiomyopathy were not considered. Informed consent was obtained from each patient after an appropriate explanation of risks and potential complications of the proposed study. Cardiac catheterization Protocol. Cardiac catheterization was performed at the time of adm ...
Antihypertensive drug
Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.